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chr8:8,092,025-12,973,575

Best TWAS P=1.17e-10 · Best GWAS P=1.19e-09 conditioned to 0.0147

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
45	NTR	Blood	MSRA	0.02	0.01	blup	833	0.01	2.3e-05	4.1	-6.4	1.2e-10	-0.66	0.25	0.74	TRUE
21	GTEx	Cells Transformed fibroblasts	ERI1	0.34	0.35	lasso	7	0.35	1.9e-27	5.9	-6.2	5.8e-10	-0.52	0.00	1.00	FALSE
51	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ERI1	0.05	0.01	blup	72	0.01	5.0e-02	5.9	-6.1	1.3e-09	-0.39	0.00	0.87	FALSE
39	GTEx	Skin Sun Exposed Lower leg	FAM85A	0.09	0.04	enet	28	0.04	1.4e-04	-4.8	6.0	2.2e-09	0.35	0.03	0.94	FALSE
49	ROSMAP	Brain Pre-frontal Cortex	RP11-481A20.11	0.06	0.04	blup	286	0.04	2.2e-06	4.9	5.9	3.3e-09	0.52	0.15	0.84	FALSE
46	ROSMAP	Brain Pre-frontal Cortex	XKR6	0.11	0.10	enet	23	0.13	1.2e-16	-4.4	5.9	4.6e-09	0.64	0.56	0.44	FALSE
29	GTEx	Esophagus Muscularis	AF131215.9	0.14	0.17	enet	16	0.17	1.6e-10	-5.0	5.8	5.9e-09	0.66	0.62	0.38	FALSE
40	GTEx	Skin Sun Exposed Lower leg	AF131215.9	0.19	0.17	enet	29	0.21	3.9e-17	-5.0	5.8	6.5e-09	0.65	0.77	0.23	FALSE
9	GTEx	Adrenal Gland	AF131215.9	0.18	0.16	lasso	10	0.18	3.5e-07	5.4	5.8	8.2e-09	0.66	0.22	0.78	FALSE
41	GTEx	Testis	AF131215.2	0.28	0.18	enet	41	0.17	8.0e-08	-4.7	5.8	8.2e-09	0.62	0.66	0.33	FALSE
35	GTEx	Pancreas	AF131215.9	0.25	0.24	enet	14	0.22	1.0e-09	5.5	5.7	1.0e-08	0.64	0.20	0.80	FALSE
8	GTEx	Adrenal Gland	AF131215.2	0.20	0.16	enet	12	0.13	2.2e-05	5.4	5.7	1.1e-08	0.65	0.21	0.78	FALSE
12	GTEx	Artery Aorta	AF131215.2	0.09	0.09	lasso	7	0.08	2.0e-05	-5.1	5.7	1.1e-08	0.68	0.25	0.73	FALSE
42	GTEx	Thyroid	AF131215.2	0.11	0.15	enet	17	0.18	1.2e-13	-4.7	5.7	1.1e-08	0.65	0.79	0.21	FALSE
13	GTEx	Artery Aorta	AF131215.9	0.13	0.05	lasso	6	0.07	1.3e-04	5.5	5.7	1.3e-08	0.66	0.21	0.78	FALSE
34	GTEx	Pancreas	AF131215.2	0.16	0.16	enet	17	0.15	9.1e-07	-5.0	5.7	1.3e-08	0.64	0.39	0.61	FALSE
30	GTEx	Heart Left Ventricle	AF131215.2	0.05	0.01	enet	11	0.01	1.5e-01	5.2	5.7	1.6e-08	0.64	0.22	0.53	FALSE
36	GTEx	Prostate	AF131215.2	0.18	0.02	lasso	6	0.02	9.6e-02	3.5	5.6	1.6e-08	0.86	0.07	0.57	FALSE
48	ROSMAP	Brain Pre-frontal Cortex	AF131215.3	0.08	0.10	lasso	7	0.12	8.3e-16	5.5	5.6	1.6e-08	0.68	0.20	0.80	FALSE
18	GTEx	Breast Mammary Tissue (Female)	AF131215.9	0.04	-0.01	enet	6	0.02	7.3e-02	-4.8	5.6	1.7e-08	0.62	0.08	0.17	FALSE
26	GTEx	Esophagus Mucosa	AF131215.9	0.18	0.16	lasso	14	0.19	1.6e-12	4.9	5.6	2.4e-08	0.68	0.28	0.72	FALSE
31	GTEx	Heart Left Ventricle	AF131215.9	0.07	0.10	enet	8	0.10	9.4e-06	-5.0	5.6	2.5e-08	0.63	0.43	0.52	FALSE
33	GTEx	Nerve Tibial	AF131215.2	0.19	0.18	lasso	12	0.23	3.5e-16	-4.7	5.6	2.8e-08	0.68	0.47	0.52	FALSE
1	CommonMind	Brain Pre-frontal Cortex	FAM86B1	0.02	0.02	lasso	3	0.01	1.3e-02	5.2	5.5	2.9e-08	0.55	0.01	0.96	FALSE
6	GTEx	Adipose Visceral Omentum	AF131215.9	0.18	0.16	lasso	7	0.16	2.0e-08	5.2	5.5	3.9e-08	0.64	0.31	0.69	FALSE
11	GTEx	Artery Aorta	ERI1	0.11	0.08	lasso	5	0.10	5.1e-06	5.9	-5.5	4.1e-08	-0.54	0.00	1.00	FALSE
53	The Cancer Genome Atlas	Lung Adenocarcinoma	ERI1	0.06	0.04	blup	72	0.04	1.5e-05	5.0	-5.5	4.3e-08	-0.46	0.03	0.97	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	RP1L1	0.02	0.01	lasso	2	0.01	4.1e-03	5.2	5.4	5.3e-08	0.57	0.01	0.89	FALSE
4	GTEx	Adipose Subcutaneous	FAM85A	0.06	0.06	enet	10	0.07	3.3e-06	-4.8	5.4	5.4e-08	0.38	0.03	0.95	FALSE
28	GTEx	Esophagus Muscularis	FAM85A	0.10	0.01	enet	20	0.04	2.7e-03	-4.8	5.4	5.9e-08	0.41	0.02	0.94	FALSE
14	GTEx	Artery Tibial	FAM85A	0.09	0.06	enet	18	0.08	1.5e-06	-4.8	5.4	6.5e-08	0.40	0.03	0.95	FALSE
43	GTEx	Uterus	AF131215.2	0.17	0.07	enet	13	0.09	7.1e-03	5.4	5.4	6.7e-08	0.71	0.13	0.53	FALSE
5	GTEx	Adipose Visceral Omentum	AF131215.2	0.12	0.08	lasso	6	0.06	4.6e-04	5.2	5.4	6.8e-08	0.65	0.37	0.58	FALSE
17	GTEx	Breast Mammary Tissue	AF131215.9	0.10	0.10	lasso	8	0.12	8.7e-07	-4.3	5.4	6.8e-08	0.71	0.37	0.61	FALSE
25	GTEx	Esophagus Mucosa	AF131215.2	0.15	0.14	enet	15	0.18	4.3e-12	-4.7	5.4	8.7e-08	0.62	0.87	0.13	FALSE
7	GTEx	Adrenal Gland	FAM86B3P	0.16	0.00	enet	18	0.03	2.2e-02	4.4	-5.3	8.9e-08	-0.33	0.05	0.12	FALSE
3	GTEx	Adipose Subcutaneous	AF131215.2	0.24	0.15	lasso	7	0.14	3.5e-11	-5.1	5.3	9.7e-08	0.62	0.51	0.49	FALSE
15	GTEx	Brain Cerebellar Hemisphere	AF131215.2	0.15	0.17	lasso	3	0.09	3.0e-03	-5.0	5.3	1.1e-07	0.59	0.21	0.30	FALSE
16	GTEx	Breast Mammary Tissue	AF131215.2	0.16	0.15	lasso	6	0.12	1.1e-06	-5.1	5.3	1.1e-07	0.68	0.52	0.45	FALSE
2	CommonMind	Brain Pre-frontal Cortex	FAM90A25P	0.11	0.08	lasso	3	0.08	1.4e-09	4.9	5.3	1.3e-07	0.48	0.01	0.99	FALSE
20	GTEx	Cells EBV-transformed lymphocytes	AF131215.9	0.20	0.15	enet	19	0.13	5.6e-05	-5.0	5.3	1.3e-07	0.59	0.48	0.35	FALSE
27	GTEx	Esophagus Muscularis	ERI1	0.12	0.09	enet	13	0.08	7.7e-06	4.8	-5.3	1.3e-07	-0.53	0.07	0.92	FALSE
19	GTEx	Cells EBV-transformed lymphocytes	AF131215.2	0.20	0.10	enet	14	0.11	1.5e-04	-5.0	5.3	1.4e-07	0.63	0.46	0.44	FALSE
37	GTEx	Skin Not Sun Exposed Suprapubic	AF131215.9	0.17	0.14	lasso	8	0.19	9.4e-11	-5.0	5.2	1.7e-07	0.62	0.53	0.47	FALSE
44	GTEx	Vagina	AF131215.9	0.21	0.11	lasso	9	0.08	6.3e-03	5.2	5.2	1.7e-07	0.63	0.18	0.66	FALSE
22	GTEx	Colon Sigmoid	AF131215.2	0.10	0.00	enet	7	0.02	5.0e-02	5.7	5.2	1.9e-07	0.62	0.14	0.45	FALSE
24	GTEx	Colon Transverse	AF131215.9	0.12	0.14	enet	18	0.12	4.0e-06	-5.0	5.1	2.6e-07	0.61	0.38	0.59	FALSE
47	ROSMAP	Brain Pre-frontal Cortex	FAM66A	0.23	0.26	enet	29	0.30	4.7e-39	5.2	5.1	2.7e-07	0.50	0.00	1.00	FALSE
23	GTEx	Colon Sigmoid	AF131215.9	0.11	0.17	enet	5	0.09	4.9e-04	-5.0	5.1	2.9e-07	0.59	0.31	0.30	FALSE
32	GTEx	Lung	AF131215.2	0.12	0.08	lasso	5	0.08	1.0e-06	-5.0	5.1	2.9e-07	0.57	0.66	0.34	FALSE
38	GTEx	Skin Sun Exposed Lower leg	AF131215.2	0.14	0.11	lasso	9	0.16	4.3e-13	-4.7	5.1	2.9e-07	0.62	0.82	0.18	FALSE
10	GTEx	Artery Aorta	FDFT1	0.09	0.02	lasso	4	0.03	6.1e-03	3.7	5.1	3.0e-07	0.49	0.15	0.42	FALSE
50	ROSMAP	Brain Pre-frontal Cortex	FAM85A	0.11	0.07	enet	23	0.11	4.3e-14	5.2	5.1	3.1e-07	0.51	0.01	0.99	FALSE