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chr16:29,972,690-31,833,122

Best TWAS P=3.54e-10 · Best GWAS P=7.87e-11 conditioned to 0.0249

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
5	GTEx	Adrenal Gland	KAT8	0.11	0.06	enet	11	0.07	1.8e-03	-6.2	6.3	3.5e-10	-0.85	0.04	0.87	TRUE
22	GTEx	Whole Blood	HSD3B7	0.06	0.06	lasso	4	0.06	2.6e-06	-6.2	-6.3	3.9e-10	0.91	0.03	0.97	FALSE
32	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ZNF668	0.03	0.01	lasso	3	0.01	2.5e-02	-5.8	-6.3	4.1e-10	0.88	0.01	0.91	FALSE
15	GTEx	Liver	PRSS53	0.22	0.08	lasso	5	0.11	5.5e-04	-6.4	6.2	7.4e-10	-0.90	0.02	0.94	FALSE
10	GTEx	Brain Frontal Cortex BA9	KAT8	0.16	0.20	lasso	1	0.17	2.6e-05	-6.2	6.2	7.5e-10	-0.85	0.04	0.87	FALSE
16	GTEx	Liver	VKORC1	0.22	0.20	lasso	5	0.22	1.1e-06	-5.8	6.1	1.3e-09	-0.92	0.03	0.97	FALSE
33	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	VKORC1	0.03	0.04	lasso	3	0.04	3.2e-05	-6.0	6.0	1.8e-09	-0.89	0.02	0.98	FALSE
34	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ZNF668	0.02	0.02	blup	32	0.02	2.9e-03	-6.1	-5.9	3.8e-09	0.86	0.01	0.95	FALSE
28	YFS	Blood	ZNF668	0.10	0.12	bslmm	232	0.12	1.5e-36	-5.8	-5.9	4.4e-09	0.88	0.04	0.96	FALSE
27	ROSMAP	Brain Pre-frontal Cortex	ZNF646	0.06	0.01	bslmm	233	0.01	1.1e-02	-6.2	5.9	4.5e-09	-0.79	0.02	0.98	FALSE
25	ROSMAP	Brain Pre-frontal Cortex	KAT8	0.13	0.16	lasso	5	0.16	4.2e-20	-6.1	5.9	4.7e-09	-0.81	0.03	0.97	FALSE
9	GTEx	Brain Cortex	KAT8	0.14	0.14	lasso	3	0.10	8.9e-04	-5.4	5.8	5.0e-09	-0.96	0.02	0.88	FALSE
14	GTEx	Esophagus Mucosa	BCKDK	0.05	0.05	enet	6	0.06	8.7e-05	-5.8	-5.8	5.3e-09	0.86	0.05	0.89	FALSE
26	ROSMAP	Brain Pre-frontal Cortex	ZNF668	0.11	0.11	lasso	4	0.11	1.7e-14	-5.8	-5.8	5.9e-09	0.88	0.03	0.97	FALSE
40	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	MYST1	0.03	0.05	blup	34	0.03	2.1e-03	-5.8	5.8	7.3e-09	-0.85	0.02	0.91	FALSE
42	The Cancer Genome Atlas	Rectum Adenocarcinoma	MYST1	0.13	0.05	blup	35	0.06	1.9e-02	-5.9	5.8	7.4e-09	-0.83	0.01	0.62	FALSE
43	The Cancer Genome Atlas	Testicular Germ Cell Tumors	MYST1	0.13	0.06	blup	34	0.12	6.8e-05	-5.6	5.8	8.9e-09	-0.81	0.02	0.94	FALSE
8	GTEx	Brain Cerebellar Hemisphere	KAT8	0.12	0.23	lasso	3	0.18	2.9e-05	-5.8	5.7	9.3e-09	-0.86	0.05	0.77	FALSE
37	The Cancer Genome Atlas	Brain Lower Grade Glioma	VKORC1	0.05	0.02	blup	36	0.03	1.0e-04	-6.0	-5.7	9.7e-09	0.79	0.02	0.89	FALSE
23	GTEx	Whole Blood	ZNF668	0.05	0.06	lasso	3	0.06	5.9e-06	-6.2	-5.7	1.0e-08	0.79	0.04	0.96	FALSE
35	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	MYST1	0.07	0.01	enet	6	0.04	1.6e-03	-5.9	5.7	1.2e-08	-0.77	0.01	0.88	FALSE
3	CommonMind	Brain Pre-frontal Cortex	ZNF646	0.04	0.06	lasso	7	0.04	4.5e-06	-6.0	5.7	1.3e-08	-0.88	0.02	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	KAT8	0.06	0.07	lasso	1	0.07	3.9e-09	-5.6	5.6	1.7e-08	-0.83	0.07	0.93	FALSE
6	GTEx	Artery Aorta	KAT8	0.23	0.20	lasso	4	0.20	2.7e-11	-5.8	5.6	1.9e-08	-0.82	0.08	0.92	FALSE
2	CommonMind	Brain Pre-frontal Cortex	VKORC1	0.03	0.04	lasso	3	0.03	4.9e-05	-5.5	-5.6	2.4e-08	0.80	0.14	0.56	FALSE
18	GTEx	Prostate	KAT8	0.19	0.09	lasso	3	0.13	3.8e-04	-5.8	5.5	3.0e-08	-0.81	0.04	0.57	FALSE
38	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNF668	0.02	0.01	enet	8	0.02	3.1e-03	-5.8	-5.5	3.3e-08	0.82	0.02	0.83	FALSE
17	GTEx	Ovary	KAT8	0.16	0.09	lasso	4	0.06	1.2e-02	-5.8	5.5	3.6e-08	-0.79	0.04	0.73	FALSE
7	GTEx	Artery Coronary	KAT8	0.22	0.19	lasso	2	0.19	6.6e-07	-5.8	5.5	4.2e-08	-0.83	0.08	0.85	FALSE
4	GTEx	Adipose Visceral Omentum	KAT8	0.07	0.02	lasso	5	0.02	4.0e-02	-5.8	5.5	4.4e-08	-0.80	0.05	0.87	FALSE
20	GTEx	Thyroid	KAT8	0.21	0.12	lasso	6	0.15	2.2e-11	-6.2	5.4	5.6e-08	-0.77	0.05	0.95	FALSE
41	The Cancer Genome Atlas	Prostate Adenocarcinoma	MYST1	0.19	0.12	blup	33	0.18	1.5e-18	-6.1	5.4	8.1e-08	-0.76	0.02	0.98	FALSE
29	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	MYST1	0.26	0.01	blup	34	0.05	1.4e-03	-5.6	5.3	9.7e-08	-0.65	0.01	0.52	FALSE
24	NTR	Blood	BCKDK	0.01	0.00	bslmm	242	0.01	2.5e-03	-5.6	-5.3	1.1e-07	0.77	0.04	0.91	FALSE
11	GTEx	Brain Nucleus accumbens basal ganglia	KAT8	0.19	0.13	lasso	4	0.18	1.4e-05	-6.1	5.2	1.6e-07	-0.73	0.05	0.69	FALSE
30	The Cancer Genome Atlas	Glioblastoma Multiforme	MYST1	0.18	0.07	blup	35	0.11	4.2e-04	-5.8	5.2	1.6e-07	-0.84	0.02	0.89	FALSE
19	GTEx	Stomach	KAT8	0.12	0.03	lasso	5	0.07	2.9e-04	2.8	5.2	1.7e-07	-0.72	0.04	0.94	FALSE
12	GTEx	Breast Mammary Tissue	KAT8	0.23	0.14	lasso	10	0.17	4.4e-09	-5.8	5.2	1.8e-07	-0.73	0.08	0.92	FALSE
21	GTEx	Uterus	FBRS	0.21	0.07	lasso	10	0.07	1.7e-02	-6.0	-5.2	1.9e-07	0.85	0.03	0.61	FALSE
13	GTEx	Esophagus Gastroesophageal Junction	KAT8	0.18	0.11	lasso	4	0.24	4.9e-09	2.8	5.2	2.0e-07	-0.76	0.07	0.93	FALSE
36	The Cancer Genome Atlas	Brain Lower Grade Glioma	MYST1	0.16	0.08	blup	34	0.12	1.5e-13	-5.8	5.2	2.0e-07	-0.70	0.02	0.98	FALSE
31	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	HSD3B7	0.06	0.01	blup	31	0.02	7.4e-04	4.1	5.2	2.3e-07	-0.75	0.04	0.82	FALSE
39	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	VKORC1	0.10	0.03	enet	7	0.07	3.8e-04	-5.8	5.1	2.6e-07	-0.86	0.01	0.96	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	MYST1	0.12	0.10	lasso	3	0.14	1.1e-13	-5.9	5.1	3.0e-07	-0.72	0.02	0.98	FALSE