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chr19:17,473,015-19,987,491

Best TWAS P=1.32e-19 · Best GWAS P=1.23e-20 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	KIAA1683	0.09	0.06	enet	14	0.10	6.6e-12	-4.23	6.8	1.0e-11	0.13	0.53	0.46	FALSE
2	GTEx	Adipose Subcutaneous	KIAA1683	0.14	0.09	enet	6	0.16	2.5e-13	-2.15	5.7	9.6e-09	0.02	0.28	0.72	FALSE
3	GTEx	Adipose Subcutaneous	AC005253.4	0.11	0.06	enet	23	0.04	1.6e-04	0.23	5.9	4.1e-09	0.22	0.30	0.24	FALSE
4	GTEx	Colon Transverse	SSBP4	0.18	0.01	enet	21	0.00	3.6e-01	6.07	-6.8	1.4e-11	-0.25	0.04	0.49	TRUE
5	GTEx	Colon Transverse	KIAA1683	0.15	0.02	lasso	3	0.02	3.3e-02	-4.31	7.3	2.4e-13	0.15	0.12	0.69	FALSE
6	GTEx	Esophagus Muscularis	KIAA1683	0.10	0.04	lasso	3	0.06	1.1e-04	-2.15	5.6	1.9e-08	0.01	0.21	0.76	TRUE
7	GTEx	Esophagus Muscularis	MEF2BNB	0.12	0.00	lasso	4	0.00	7.5e-01	5.15	-5.2	1.5e-07	-0.03	0.02	0.57	TRUE
8	GTEx	Nerve Tibial	KIAA1683	0.25	0.22	lasso	9	0.28	5.2e-20	8.96	7.0	3.5e-12	0.08	0.06	0.94	FALSE
9	GTEx	Pancreas	AC007192.6	0.19	0.00	enet	28	0.01	1.3e-01	9.29	-6.5	8.9e-11	-0.29	0.02	0.72	TRUE
10	GTEx	Pituitary	KIAA1683	0.43	0.25	lasso	3	0.17	3.9e-05	6.28	6.2	4.0e-10	0.12	0.14	0.31	FALSE
11	GTEx	Testis	PDE4C	0.39	0.44	lasso	2	0.43	5.8e-21	-5.81	-5.8	6.3e-09	-0.39	1.00	0.00	FALSE
12	GTEx	Testis	AC068499.10	0.38	0.41	lasso	3	0.40	6.8e-19	-5.81	-5.9	3.0e-09	-0.41	1.00	0.00	FALSE
13	GTEx	Thyroid	KIAA1683	0.11	0.07	enet	14	0.12	2.1e-09	6.28	8.6	8.2e-18	0.23	0.14	0.86	FALSE
14	GTEx	Vagina	LRRC25	0.63	0.02	enet	2	0.04	5.3e-02	8.96	-8.9	3.5e-19	-0.20	0.04	0.21	FALSE
15	METSIM	Adipose	IL12RB1	0.05	0.05	lasso	3	0.04	2.8e-07	5.74	-5.5	3.7e-08	-0.41	0.87	0.12	FALSE
16	NTR	Blood	IFI30	0.03	0.02	lasso	6	0.02	8.8e-08	8.71	7.2	4.2e-13	0.31	0.21	0.79	FALSE
17	ROSMAP	Brain Pre-frontal Cortex	PDE4C	0.18	0.12	enet	17	0.19	3.3e-24	-3.04	-6.1	8.5e-10	-0.22	0.92	0.08	TRUE
18	ROSMAP	Brain Pre-frontal Cortex	KIAA1683	0.23	0.14	bslmm	409	0.24	1.4e-30	-2.15	6.1	8.3e-10	0.05	0.29	0.71	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	JUND	0.17	0.17	lasso	5	0.20	2.7e-25	8.96	7.7	9.8e-15	0.13	0.07	0.93	TRUE
20	ROSMAP	Brain Pre-frontal Cortex	KLHL26	0.22	0.13	bslmm	382	0.18	2.6e-22	-4.74	5.4	6.7e-08	0.01	1.00	0.00	FALSE
21	YFS	Blood	IFI30	0.08	0.04	bslmm	405	0.08	1.1e-23	-1.70	6.1	1.2e-09	0.12	0.97	0.03	FALSE
22	YFS	Blood	KIAA1683	0.51	0.40	enet	65	0.46	9.9e-171	8.93	6.8	1.5e-11	0.05	0.09	0.91	FALSE
23	YFS	Blood	MAST3	0.06	0.04	lasso	5	0.04	4.2e-12	9.29	-8.8	1.2e-18	-0.56	0.00	1.00	FALSE
24	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	IL12RB1	0.07	0.02	lasso	3	0.01	6.4e-02	5.74	-5.9	4.7e-09	-0.43	0.13	0.13	FALSE
25	The Cancer Genome Atlas	Glioblastoma Multiforme	JUND	0.17	0.00	blup	57	0.03	5.4e-02	8.96	8.3	7.1e-17	0.25	0.00	0.70	FALSE
26	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	IL12RB1	0.05	0.03	enet	11	0.05	2.3e-06	-2.27	-5.3	1.3e-07	-0.44	0.52	0.35	FALSE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	KIAA1683	0.05	0.03	lasso	4	0.04	9.1e-06	-4.23	5.2	2.6e-07	0.03	0.62	0.36	FALSE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IL12RB1	0.10	0.08	blup	58	0.09	6.9e-10	6.07	-5.6	1.9e-08	-0.35	1.00	0.00	FALSE
29	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	JUND	0.05	0.04	lasso	1	0.04	4.3e-05	8.96	9.0	3.3e-19	0.20	0.00	0.99	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	KIAA1683	0.09	0.07	lasso	8	0.12	2.1e-13	-2.16	5.6	2.5e-08	0.06	0.75	0.25	FALSE
31	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	MAST3	0.04	0.02	blup	65	0.01	7.3e-02	9.29	-6.9	6.0e-12	-0.53	0.00	0.69	FALSE
32	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	JUND	0.11	0.03	blup	58	0.04	1.4e-03	-3.75	8.0	1.2e-15	0.22	0.03	0.41	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	JUND	0.04	0.03	lasso	2	0.02	7.9e-04	8.96	8.9	7.2e-19	0.19	0.00	0.99	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	MAST3	0.02	0.02	lasso	3	0.01	1.5e-02	9.01	-9.1	1.3e-19	-0.95	0.01	0.91	TRUE
35	The Cancer Genome Atlas	Lung Adenocarcinoma	IL12RB1	0.10	0.08	enet	13	0.07	3.9e-08	6.07	-5.4	7.6e-08	-0.23	1.00	0.00	FALSE
36	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	IL12RB1	0.07	0.04	blup	58	0.06	4.9e-07	5.19	-7.0	2.1e-12	-0.57	0.87	0.11	TRUE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	KIAA1683	0.09	0.05	lasso	4	0.06	1.3e-07	8.96	6.5	6.0e-11	0.05	0.03	0.97	FALSE
38	The Cancer Genome Atlas	Soft Tissue Sarcoma	KIAA1683	0.07	0.00	blup	64	0.01	4.5e-02	-4.33	5.4	7.7e-08	0.09	0.03	0.22	FALSE
39	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CRTC1	0.33	0.08	lasso	5	0.12	3.6e-05	-4.74	-5.9	3.6e-09	0.04	0.04	0.52	TRUE
40	The Cancer Genome Atlas	Testicular Germ Cell Tumors	IL12RB1	0.10	0.01	enet	10	0.06	2.6e-03	1.99	-7.0	1.8e-12	-0.62	0.01	0.65	FALSE
41	The Cancer Genome Atlas	Testicular Germ Cell Tumors	KIAA1683	0.17	0.06	blup	65	0.06	3.0e-03	-3.48	5.3	1.4e-07	0.04	0.05	0.61	FALSE
42	The Cancer Genome Atlas	Thyroid Carcinoma	IL12RB1	0.08	0.04	lasso	3	0.05	8.9e-06	4.10	-5.8	4.8e-09	-0.46	0.33	0.47	FALSE
43	The Cancer Genome Atlas	Thyroid Carcinoma	KIAA1683	0.15	0.09	lasso	6	0.16	5.4e-15	6.19	5.5	3.4e-08	0.03	0.94	0.06	FALSE
44	The Cancer Genome Atlas	Thyroid Carcinoma	MAST3	0.04	0.02	lasso	2	0.00	3.4e-01	9.01	-9.0	2.5e-19	-0.95	0.02	0.81	FALSE