Hub : Genes

MEF2BNB

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0640	0.0240	0.00055	0.047	0.030	0.042	0.033	0.046	2.0e-06	0.00012	6.1e-06	5.7e-05	2.4e-06
2	GTEx	Esophagus Muscularis	0.1210	0.0540	0.00780	-0.005	NA	-0.005	NA	-0.004	9.9e-01	NA	1.0e+00	NA	7.5e-01
3	GTEx	Muscle Skeletal	0.0643	0.0282	0.00820	-0.002	NA	-0.002	NA	-0.002	6.7e-01	NA	5.2e-01	NA	6.6e-01
4	ROSMAP	Brain Pre-frontal Cortex	0.0897	0.0315	0.00022	0.031	0.027	0.032	0.028	0.029	5.7e-05	0.00019	5.5e-05	1.2e-04	1.2e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.5	0.8	1.8	-1.4	0.7	1.0	-0.0
Bipolar Disorder or Schizophrenia	0.2	0.6	1.4	-1.2	-0.8	0.5	0.4
Depressed Affect (Nagel 2018)	2.1	4.5	6.7	2.1	-2.2	-1.5	2.6
Depression (Nagel 2018)	0.4	0.6	1.0	0.6	-1.0	-0.8	0.6
Intelligence (Savage-Jansen 2018)	1.1	3.5	6.7	-2.6	1.2	1.8	-1.6
Neuroticism (Nagel 2018)	1.2	2.8	5.5	1.6	-1.6	-1.0	2.3
Schizophrenia (2018)	0.3	0.7	2.2	-0.4	-1.5	-0.2	0.6
Schizophrenia vs Biploar Disorder	2.2	2.9	3.7	1.7	-1.8	-1.9	1.3
Worry (Nagel 2018)	0.0	0.1	0.2	0.2	-0.1	-0.3	0.5
Alzheimer’s Disease (in mother)	1.0	1.2	2.2	-0.9	-1.5	1.3	-0.2
Alzheimer’s Disease (in father)	2.0	2.2	3.1	1.5	-1.8	-1.4	1.2
Alzheimer’s Disease (including proxy)	1.7	2.5	7.6	0.8	-2.8	-0.5	1.2
Crohns Disease (2017)	0.2	0.5	1.1	0.4	-0.8	0.1	1.0
Irritable Bowel Disease (IBD)	0.9	2.1	3.9	1.4	-1.2	-1.1	2.0
Ulcerative Colitis (UC)	1.7	3.1	4.8	1.9	-0.9	-1.9	2.2
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Reaction Time	1.5	2.8	4.5	-2.1	-0.9	1.5	-1.9
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.4	-1.2	0.1	0.5	-0.4
Breast Cancer	3.2	7.7	16.9	-2.1	1.9	2.4	-4.1
Ovarian Cancer	0.4	0.6	1.5	-0.2	1.2	0.2	-0.9
Prostate Cancer	1.1	1.5	4.6	1.0	-0.4	-0.6	2.1
Age at First Birth	0.4	0.5	1.4	-0.5	1.2	0.6	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.6	0.8	1.3	-1.0	0.0	0.8	-1.2
Coronary Artery Disease (CAD)	3.3	3.9	5.8	-1.7	2.4	1.5	-2.2
Crohns Disease (2012)	0.5	0.9	2.6	0.4	-1.6	0.2	0.8
Mean Putamen Volume	0.5	0.6	1.4	0.5	1.2	-0.2	0.9
Fasting Glucose	0.4	0.5	1.3	0.5	-1.1	-0.2	-0.7
HbA1C	1.8	2.0	3.6	1.1	-1.9	-1.7	0.6
HDL Cholesterol	0.4	0.7	2.6	-0.1	1.6	-0.0	0.1
LDL Cholesterol	4.1	6.6	11.6	-3.4	-1.1	2.1	-3.0
Lupus	3.6	5.4	7.4	-2.3	2.7	2.2	-2.0
Neuroticism (2016)	0.5	0.8	2.7	0.1	-1.6	0.2	0.6
Primary Biliary Cirrhosis	0.3	0.5	1.8	0.1	1.4	-0.1	0.2
Rheumatoid Arthritis	1.1	1.5	2.6	-1.6	1.1	1.2	-0.8
Schizophrenia (2014)	0.3	0.7	1.5	-1.0	-1.2	0.4	0.3
Triglycerides	2.4	4.0	7.6	-2.8	-0.9	1.5	-2.3
Type 2 Diabetes (T2D) (2012)	0.3	0.4	0.6	-0.8	0.8	0.5	-0.4
Ulcerative Colitis	1.7	2.4	2.9	1.5	-1.7	-1.2	1.7
Blood Eosinophil Count	1.5	11.8	21.5	3.5	-1.8	-3.2	4.6
Blood Platelet Count	0.2	2.5	3.8	-0.3	-1.7	1.8	2.0
Blood Red Count	0.5	5.2	11.4	3.4	-1.1	-2.3	1.6
Blood White Count	0.5	4.1	9.7	2.3	-0.3	-1.1	3.1
Heel T-Score	0.1	0.7	2.3	-0.1	-1.5	0.3	0.6
BMI	1.9	11.2	27.0	2.2	-5.2	-2.4	2.6
Height	0.8	15.1	46.2	-3.0	6.8	2.0	-0.9
Waist Hip Ratio (WHR)	0.1	0.6	1.2	1.1	0.6	-0.7	0.5
Systolic Blood Pressure	0.4	2.0	7.3	0.6	2.7	-0.3	0.5
Smoking Status	1.2	2.9	6.6	-1.8	-1.0	2.6	-0.8
Allergy or Eczema	0.7	1.8	4.5	1.0	-0.9	-2.1	0.9
Cardiovascular Disease	0.6	1.9	3.2	1.8	0.8	-1.5	1.3
Hypothyroidism (self reported)	0.4	0.9	2.1	-1.0	0.7	1.5	-0.2
Respiratory disease	0.3	0.8	1.0	0.7	-0.8	-0.9	1.0
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.7	0.8	-0.4	-0.5	0.7
Lung FEV1/FVC ratio	1.2	6.0	9.1	2.6	-1.7	-3.0	2.3
Lung FVC	0.0	0.1	0.2	-0.4	-0.3	0.4	-0.5
Neuroticism	0.5	1.2	2.3	1.0	-1.1	-0.7	1.5
Chronotype (morning person)	1.3	3.0	6.3	1.2	2.5	-2.0	0.4
Hair Pigment	0.0	0.8	2.1	1.4	-0.9	-0.5	0.5
Tanning	0.0	0.3	0.4	-0.0	-0.6	0.5	0.6
Hand grip strength (left)	1.0	2.8	6.5	-1.2	2.5	0.9	-1.5
Number of treatments/medications taken	3.3	6.0	8.5	2.9	-2.1	-2.0	2.6
Average weekly spirits intake	3.5	4.3	14.4	1.0	-3.8	-0.4	1.3
Sensitivity / hurt feelings	0.8	1.3	3.1	1.2	-0.7	-0.6	1.8
Frequency of depressed mood in last 2 weeks	0.7	1.0	1.7	-1.3	0.0	0.9	-1.3
Hearing difficulty/problems: Yes	0.2	0.3	0.6	-0.4	0.0	0.6	-0.8
Relative age of first facial hair	0.1	0.2	0.5	0.2	0.7	0.6	0.1
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	1.3	1.1	-1.0	-1.0	1.1
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.6	0.8	0.2	-0.1	0.4
Ever had hysterectomy (womb removed)	2.0	2.2	3.0	-1.6	-1.1	1.7	-1.4
Systolic blood pressure, automated reading	0.0	0.0	0.1	-0.3	-0.1	0.2	0.2
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	1.4	-0.2	1.2	1.1	-0.2
Angina	0.4	0.5	0.8	0.8	-0.8	-0.9	0.1
Medication for hormone replacement therapy	0.3	0.3	0.5	-0.7	0.1	0.6	-0.6
Vitamin and mineral supplements	0.3	0.4	0.7	-0.4	0.6	0.5	-0.8
Supplements: Zinc	0.4	0.4	1.3	-0.5	-1.1	-0.2	0.2
Medication: Co-codamol	0.5	0.6	1.8	-0.1	-1.3	0.0	0.7
Medication: Metformin	0.1	0.1	0.3	0.5	0.3	-0.4	0.1
Diabetes (father)	1.0	1.2	1.9	1.1	-0.1	-1.4	1.3
Diabetes (mother)	1.7	2.2	3.2	1.8	-0.5	-1.7	1.6
Severe depression (siblings)	1.2	1.3	4.0	0.0	-2.0	-0.6	0.9
Pack years adult smoking proportion	2.6	4.0	6.3	1.6	-2.0	-1.8	2.5
Impedance of leg (right)	0.2	1.2	2.5	-0.3	-1.2	1.6	0.8
Leg fat-free mass (left)	0.2	0.9	2.7	-0.2	1.6	-0.9	0.2
Trunk fat percentage	1.6	6.3	19.0	0.5	-4.4	-0.8	2.3
Hand grip strength (right)	1.1	3.0	6.6	-1.3	2.6	1.0	-1.7
Townsend deprivation index at recruitment	0.6	0.9	1.4	0.9	-0.9	-1.2	0.6
Current tobacco smoking	0.9	1.5	5.0	-0.1	-2.2	0.6	0.7
Average weekly fortified wine intake	0.1	0.1	0.1	0.3	-0.2	0.1	-0.4
Maternal smoking around birth	1.0	1.4	2.6	0.4	-1.6	0.8	1.5
Fed-up feelings	1.5	2.8	4.4	1.6	-1.4	-1.4	2.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.6	0.7	-0.1	-0.8	0.6
Relative age voice broke	1.5	2.3	2.7	-1.4	1.6	1.4	-1.6
Taking other prescription medications	2.2	3.4	6.8	1.4	-2.6	-0.9	1.9
Age when periods started (menarche)	0.1	0.2	0.3	0.5	0.5	-0.4	0.5
Bilateral oophorectomy (both ovaries removed)	2.6	3.0	4.4	-2.1	-1.8	1.6	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	1.1	0.7	-0.9	-1.0	0.8
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	1.6	-0.4	1.2	-0.4	-0.4
Qualifications: CSEs or equivalent	0.1	0.2	0.4	-0.3	-0.6	0.4	0.1
Serious illness, injury or assault to yourself	0.7	0.9	1.4	-1.2	-0.4	0.9	-1.1
High blood pressure	2.0	5.4	8.8	3.0	1.4	-2.2	2.5
Hayfever, allergic rhinitis or eczema	0.6	1.3	3.5	1.1	0.0	-1.9	0.7
Multivitamins +/- minerals	1.4	1.8	2.8	1.4	-0.6	-1.4	1.7
Stomach or abdominal pain in last month	0.4	0.5	1.8	0.4	-1.4	-0.2	0.1
Supplements: Glucosamine	1.0	1.2	4.3	-0.4	2.1	-0.3	-0.6
Diverticular disease/diverticulitis (self-reported)	1.9	2.2	6.7	0.7	-2.6	-1.1	0.7
Medication: Atenolol	0.3	0.3	0.7	0.8	0.3	-0.5	0.6
Medication: Levothyroxine sodium	0.1	0.2	0.9	0.2	-0.1	0.1	0.9
Sitting height	0.8	5.8	16.3	-2.0	4.0	1.7	-0.4
Chronic bronchitis/emphysema (father)	1.1	1.3	2.3	1.2	-0.5	-1.1	1.5
High blood pressure (mother)	0.9	1.2	3.3	0.4	1.8	-0.4	1.1
Body mass index (BMI)	2.3	9.8	23.3	2.0	-4.8	-2.2	2.6
Impedance of leg (left)	0.2	0.8	2.1	-0.2	-0.8	1.4	0.8
Leg predicted mass (left)	0.2	0.9	2.7	-0.2	1.6	-1.0	0.3
Trunk fat mass	1.2	5.0	12.3	0.7	-3.5	-1.2	2.4
Waist circumference	1.7	6.3	9.8	2.0	-3.1	-2.1	2.6
Number of incorrect matches in round	0.4	0.6	1.2	-0.4	-0.1	1.0	-1.1
Past tobacco smoking	1.0	1.9	4.8	1.6	0.4	-2.2	0.4
Alcohol usually taken with meals	0.8	1.3	1.6	-1.1	1.1	1.3	-1.0
Nervous feelings	0.1	0.3	0.4	0.5	0.3	-0.6	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.2	-1.0	1.1	0.3	-1.5
Hearing difficulty/problems with background noise	1.4	2.2	4.5	2.1	-0.4	-1.6	1.4
Hair/balding pattern: Pattern 2	4.2	5.4	7.7	2.1	-2.8	-2.0	2.4
Had menopause	0.1	0.1	0.5	0.7	-0.1	0.0	0.1
Had other major operations	1.1	1.4	2.3	1.0	-1.4	-0.6	1.5
Forced vital capacity (FVC)	0.8	3.0	9.5	-1.0	3.1	0.9	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	0.3	-0.6	0.0	0.4	-0.4
Ever unenthusiastic/disinterested for a whole week	3.3	4.0	5.6	2.0	-2.4	-1.7	1.9
Qualifications: None of the above	2.1	4.6	8.2	2.0	-2.9	-1.1	2.2
Financial difficulties in last 2 years	0.5	0.7	2.6	0.1	-1.6	-0.3	0.1
Mouth/teeth dental problems	6.7	10.3	13.9	-3.3	3.7	2.6	-3.1
Heart attack	1.0	1.2	2.2	1.1	-1.0	-0.7	1.5
Allergy	0.7	1.6	3.2	-1.1	1.0	1.8	-1.0
Pain all over the body in last month	0.2	0.2	0.9	-0.1	-0.9	0.1	-0.1
Diabetes (self-reported)	0.8	1.2	4.2	0.7	2.0	-0.2	0.2
Hayfever/allergic rhinitis (self-reported)	2.0	2.6	3.6	-1.9	0.9	1.7	-1.8
Medication: Ramipril	1.4	1.7	5.2	1.3	-0.1	-0.3	2.3
Medication: Simvastatin	0.2	0.3	0.7	0.0	0.8	-0.6	-0.1
Fluid intelligence score	0.8	1.6	3.3	-1.3	1.8	0.6	-1.1
Illnesses of siblings	0.3	0.4	0.6	-0.8	-0.4	0.5	-0.7
Neuroticism score	0.2	0.5	1.2	0.4	-0.7	-0.2	1.1
Weight	0.5	2.5	4.0	0.8	-1.8	-1.4	2.0
Impedance of arm (right)	1.7	8.1	12.6	-3.5	1.9	3.4	-2.2
Arm fat percentage (right)	1.7	6.9	21.6	0.7	-4.7	-1.1	2.0
Trunk fat-free mass	0.4	2.1	7.5	0.3	2.7	-0.9	0.3
Hip circumference	0.8	3.3	7.6	0.6	-2.8	-1.2	2.0
Time employed in main current job	3.5	4.1	7.8	1.6	-1.9	-1.4	2.8
Alcohol intake versus 10 years previously	2.7	4.0	6.3	1.9	-2.1	-1.4	2.5
Father’s age at death	0.1	0.2	0.4	-0.6	0.4	0.2	-0.2
Worrier / anxious feelings	0.0	0.1	0.2	0.0	0.2	0.2	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.3	0.2	-1.5	-0.3	0.8
Falls in the last year	1.8	2.4	4.4	1.1	-2.1	-0.7	1.9
Hair/balding pattern: Pattern 3	0.1	0.1	0.2	-0.4	-0.4	0.3	-0.2
Number of live births	0.2	0.3	0.5	0.5	-0.7	-0.1	0.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.5	5.8	-0.2	2.4	0.0	-0.1
Pulse rate	0.0	0.1	0.1	0.2	-0.3	0.2	0.2
Happiness	0.6	0.7	2.5	-0.0	-1.6	-0.6	0.2
Noisy workplace	0.1	0.1	0.2	-0.2	-0.2	0.5	-0.2
Qualifications: A levels/AS levels or equivalent	1.5	3.3	5.4	-2.2	1.2	1.2	-2.3
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.6	0.2	1.6	-0.7	0.2
Mouth/teeth dental problems: Dentures	3.4	5.7	7.1	2.6	-1.8	-2.5	2.7
Asthma	0.6	1.2	3.0	0.5	-1.7	-1.0	0.8
Medication: Ibuprofen (e.g. Nurofen)	2.3	2.9	9.9	0.5	-3.1	-0.4	1.2
Medication: Cholesterol lowering	0.1	0.1	0.2	-0.0	-0.4	-0.4	-0.2
Depression (self-reported)	2.6	3.1	8.0	1.2	-2.8	-1.3	1.1
Medication: Lansoprazole	2.2	2.5	4.2	1.9	-0.9	-1.2	2.1
Prospective memory result	1.0	1.2	2.5	1.6	-0.5	-1.3	0.7
Lung cancer (father)	4.2	4.9	7.3	2.7	-1.5	-2.0	2.5
Illnesses of mother	3.7	4.6	5.8	-2.3	1.6	2.2	-2.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	3.7	0.3	1.9	-0.6	0.1
Pulse wave Arterial Stiffness index	1.0	1.2	3.1	0.9	-1.8	-0.3	0.9
Impedance of arm (left)	1.5	7.1	11.2	-3.3	1.8	3.1	-2.2
Arm fat mass (right)	1.2	5.0	12.9	0.9	-3.6	-1.3	2.1
Trunk predicted mass	0.4	2.0	7.6	0.1	2.8	-0.7	0.2
Standing height	1.1	11.0	37.5	-2.0	6.1	1.4	-0.8
Length of working week for main job	0.1	0.2	0.3	-0.3	-0.6	0.3	0.3
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.4	-0.1	0.4	0.2
Breastfed as a baby	2.1	2.6	3.5	-1.7	1.6	1.9	-1.1
Tense / ‘highly strung’	0.1	0.2	0.4	0.4	-0.4	-0.6	0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	1.1	1.6	2.2	1.2	-1.4	-1.5	1.0
Hair/balding pattern: Pattern 4	0.0	0.0	0.1	-0.1	-0.1	0.2	-0.3
Birth weight of first child	0.2	0.4	0.8	-0.2	0.7	-0.3	0.9
Peak expiratory flow (PEF)	0.4	0.9	1.8	1.0	0.1	-1.3	1.0
Pulse wave reflection index	1.7	2.1	6.7	0.9	-2.6	-0.7	0.6
Ever highly irritable/argumentative for 2 days	3.4	4.1	9.2	1.8	-3.0	-1.4	1.4
Loud music exposure frequency	0.3	0.3	0.8	-0.4	0.1	-0.3	-0.9
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.3	-1.0	1.1	0.1	-0.4
Mouth/teeth dental problems: Bleeding gums	1.1	1.4	4.6	0.9	-2.1	-0.3	0.1
Blood clot in the leg (DVT)	0.3	0.4	0.7	-0.6	-0.0	0.8	-0.8
Medication: Paracetamol	5.7	9.5	12.7	3.2	-3.6	-2.4	3.0
Headache pain in last month	2.7	4.7	7.7	1.8	-2.8	-1.6	2.2
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.2	-0.9	0.6	0.5	-1.1
Glaucoma (self-reported)	0.2	0.3	0.7	0.5	0.3	-0.9	-0.1
Gout (self-reported)	0.1	0.1	0.2	-0.1	0.3	0.4	-0.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.8	-0.4	-0.0	0.9	0.2
Medication: Amlodipine	1.1	1.5	4.2	-0.5	2.0	0.7	-1.0
Medication: Ventolin 100micrograms inhaler	0.3	0.4	0.5	-0.6	-0.7	0.6	-0.5
Birth weight	1.7	3.7	7.8	-1.6	2.8	1.2	-1.7
Chronic bronchitis/emphysema (mother)	3.0	3.5	6.1	1.6	-2.5	-1.5	1.8
High blood pressure (siblings)	0.4	0.6	2.3	0.4	1.5	-0.1	0.3
Forced vital capacity (FVC), Best measure	0.6	2.1	6.9	-0.7	2.6	0.7	-0.6
Body fat percentage	2.3	9.2	27.6	1.0	-5.2	-1.1	2.6
Leg fat percentage (right)	4.1	14.8	44.5	1.6	-6.7	-1.3	3.2
Arm fat-free mass (right)	0.4	2.1	3.2	1.3	1.2	-1.8	1.4
Exposure to tobacco smoke outside home	0.6	0.8	1.2	-1.0	-0.2	0.9	-1.1
Comparative body size at age 10	3.7	10.1	16.4	-3.8	1.5	2.7	-4.1
Number of full brothers	0.5	0.7	1.4	-1.1	0.3	1.2	0.1
Worry too long after embarrassment	1.0	1.7	2.0	-1.4	1.3	1.4	-1.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.6	-0.4	-1.3	-0.3	-1.0
Wheeze or whistling in the chest in last year	1.6	2.9	3.8	1.9	-1.4	-1.9	1.5
Number of children fathered	6.8	7.7	14.1	2.3	-3.8	-2.0	2.7
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.4	0.4	1.2	-0.0	0.3
Age at first live birth	2.5	4.5	11.7	-1.0	3.4	1.0	-2.0
Pulse wave peak to peak time	1.8	2.1	5.5	-1.2	2.3	0.5	-1.1
Health satisfaction	1.1	1.4	2.6	1.1	-1.6	-1.1	0.7
Shortness of breath walking on level ground	1.9	2.2	2.7	1.6	-1.6	-1.3	1.4
Qualifications: College or University degree	2.6	8.3	11.8	-2.6	3.4	1.8	-3.4
Eye problems/disorders: None of the above	0.2	0.3	0.6	-0.6	0.3	0.0	-0.8
Mouth/teeth dental problems: Loose teeth	0.3	0.3	0.7	0.7	-0.1	-0.4	0.8
Emphysema/chronic bronchitis	0.2	0.2	0.3	0.1	-0.6	-0.3	0.5
Medication for pain relief, constipation, heartburn	5.5	9.3	15.1	-2.9	3.9	2.2	-3.0
Neck or shoulder pain in last month	0.9	1.3	2.3	1.2	-1.5	-0.6	1.0
Medication: Blood pressure	1.6	2.8	4.6	2.1	-0.5	-1.5	2.0
Angina (self-reported)	0.5	0.6	1.0	0.9	-1.0	-0.9	0.2
Migraine (self-reported)	4.1	5.1	9.4	2.0	-3.1	-1.9	1.8
Medication: Ibuprofen	3.6	4.3	8.9	1.6	-3.0	-1.5	1.8
Medication: Allopurinol	0.4	0.5	1.2	-0.6	0.6	1.1	-0.4
Medication: Omeprazole	0.7	0.9	2.5	0.6	-1.6	-0.2	0.8
Medication: Seretide 50 evohaler	0.2	0.2	0.4	-0.4	-0.6	0.6	-0.1
Mean time to correctly identify matches	0.5	1.0	1.3	-1.1	-1.1	0.6	-1.1
Heart disease (mother)	2.2	2.6	4.4	1.2	-2.1	-1.6	1.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.8	0.5	-0.8	-0.9	-0.3
Whole body fat mass	1.4	5.8	14.0	1.1	-3.7	-1.4	2.5
Leg fat mass (right)	2.4	9.2	23.3	1.5	-4.8	-1.6	3.0
Arm predicted mass (right)	0.4	2.0	2.8	1.3	1.2	-1.7	1.4
Pulse rate, automated reading	0.1	0.2	0.6	-0.3	-0.8	0.4	0.3
Alcohol intake frequency.	0.9	2.1	3.1	1.1	-1.8	-1.5	1.4
Comparative height size at age 10	0.6	3.2	7.9	-1.6	2.8	1.2	-0.9
Number of full sisters	0.1	0.2	0.3	0.4	-0.1	-0.5	0.5
Suffer from ‘nerves’	0.7	1.0	1.5	-1.2	-1.2	0.6	-0.9
Overall health rating	3.5	7.6	15.6	2.1	-4.0	-2.2	2.4
Chest pain or discomfort	0.2	0.4	1.4	-0.2	0.1	1.2	0.2
Had major operations	1.6	1.8	4.5	1.6	-0.4	-2.1	0.5
Age at last live birth	0.8	1.2	4.0	-0.0	2.0	-0.1	-0.9
Family relationship satisfaction	0.5	0.6	2.0	0.2	-1.4	-0.2	0.3
Leg pain on walking	1.3	1.6	3.3	1.8	0.2	-1.4	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.9	-0.9	-0.3	0.8	-0.6
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.1	-0.5	-1.0	0.5	-0.0
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.3	-0.3	1.5	1.0	-0.5
Medication: Aspirin	1.0	1.3	2.7	1.6	-0.1	-1.3	1.0
Supplements: Vitamin C	1.0	1.2	1.7	1.2	-0.7	-1.2	1.3
Knee pain experienced in last month	2.8	4.3	5.0	2.2	-2.0	-2.1	1.9
Hypertension (Self-reported)	1.7	4.7	7.8	2.8	1.0	-2.0	2.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.1	3.6	5.6	2.4	0.0	-2.0	2.2
Illnesses of father: Heart disease	1.1	1.5	3.0	-1.2	1.7	-0.2	-1.2
Illnesses of siblings: Diabetes	1.6	2.0	3.4	1.5	-1.2	-1.0	1.8
Smoking status: Previous	0.2	0.3	1.0	-0.3	0.1	1.0	0.3
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	4.9	1.1	2.2	-1.4	1.4
Whole body fat-free mass	0.3	1.8	6.0	0.2	2.5	-1.0	0.3
Leg fat-free mass (right)	0.3	1.4	4.5	-0.2	2.1	-1.0	-0.0
Arm fat percentage (left)	1.7	6.9	22.0	0.6	-4.7	-1.1	1.9
Average weekly red wine intake	2.0	2.9	3.7	-1.5	1.9	1.8	-1.6
Handedness (chirality/laterality): Left-handed	2.1	2.5	2.9	-1.7	1.6	1.3	-1.7
Mood swings	0.2	0.3	0.6	0.4	-0.6	-0.5	0.8
Loneliness, isolation	6.5	9.0	13.3	2.8	-3.6	-2.6	2.9
Long-standing illness, disability or infirmity	4.9	7.5	10.6	3.3	-1.6	-3.0	2.8
Ever had bowel cancer screening	1.4	1.6	2.5	-1.4	-0.3	1.6	-1.4
Diabetes diagnosed by doctor	0.5	0.8	1.6	1.1	1.3	-0.3	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.2	0.3	0.5	0.0	-0.1	0.6
Friendships satisfaction	0.3	0.4	0.8	0.1	-0.9	-0.0	0.8
Qualifications: nursing, teaching	0.2	0.4	0.6	-0.5	0.8	-0.4	-0.7
Commuting to job workplace: Walk	0.5	0.6	1.0	0.8	0.8	-1.0	-0.2
Eye problems/disorders: Cataract	0.6	0.7	2.5	-0.1	-1.6	0.7	0.0
Mouth/teeth dental problems: Mouth ulcers	0.9	1.4	3.1	0.7	-1.8	-0.3	1.4
Medication for cholesterol	1.4	2.1	3.3	-1.8	-1.0	1.4	-1.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	1.8	1.4	-1.0	-1.1	0.9
Back pain experienced in last month	2.6	3.7	7.8	1.5	-2.8	-1.5	1.6
Mineral and other dietary supplements	1.5	2.1	3.6	1.2	-1.9	-1.1	1.5
Breast cancer (self-reported)	0.5	0.6	1.3	-1.0	-1.1	0.4	-0.1
Asthma (self-reported)	0.8	1.7	3.0	0.9	-1.7	-1.3	1.1
Osteoporosis (self-reported)	0.2	0.2	0.7	-0.1	-0.9	0.4	-0.2
Osteoarthritis (self-reported)	4.1	5.4	6.9	2.1	-2.6	-2.4	2.1
Medication: Aspirin	1.6	2.1	4.1	2.0	0.2	-1.5	1.4
Medication: Gliclazide	0.4	0.5	0.9	-0.7	0.7	0.9	-0.5
Illnesses of father: None of the above (group 1)	0.8	1.0	1.5	-0.7	-0.8	1.2	-1.2
Smoking status: Current	0.9	1.4	3.8	-0.7	-2.0	1.1	0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	0.8	0.9	0.7	-0.8	-0.1
Whole body water mass	0.3	1.6	5.1	0.2	2.3	-1.0	0.4
Leg predicted mass (right)	0.3	1.4	4.9	-0.3	2.2	-0.9	-0.0
Arm fat mass (left)	1.2	4.9	12.7	0.9	-3.6	-1.4	2.0
Number of self-reported non-cancer illnesses	5.9	10.2	13.2	3.6	-2.5	-3.3	3.3
Average weekly champagne plus white wine intake	2.3	3.1	5.5	-1.6	1.7	1.2	-2.4
Miserableness	0.7	1.2	2.1	0.7	-1.4	-0.3	1.5
Guilty feelings	0.9	1.4	3.4	0.9	-1.8	0.1	1.1
Wears glasses or contact lenses	0.1	0.2	0.3	0.3	-0.5	-0.0	0.6
Ever taken oral contraceptive pill	0.3	0.4	1.3	0.2	-1.1	-0.2	-0.4
Hearing aid user	1.7	1.9	2.9	-1.7	-0.5	1.6	-1.4
Mother’s age at death	0.4	0.5	1.0	0.6	-0.5	-1.0	-0.7
Financial situation satisfaction	0.3	0.4	1.1	-0.7	-0.2	0.1	-1.0
Tinnitus: Yes, now most or all of the time	1.6	1.9	3.3	1.1	-1.8	-1.1	1.4
Commuting to job workplace: Public transport	0.3	0.4	1.1	-0.2	0.7	0.3	-1.0
Eye problems/disorders: Glaucoma	0.4	0.5	0.8	0.5	0.9	-0.8	0.1
Medication: Blood pressure	1.5	2.9	4.1	2.0	1.6	-1.4	1.8
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.8	0.4	-0.7	0.7	0.9
Supplements: Fish oil (including cod liver oil)	2.6	3.3	6.1	-1.2	2.5	1.5	-1.9
High cholesterol (Self-reported)	0.1	0.1	0.4	0.1	-0.2	-0.6	-0.4
Medication: Bendroflumethiazide	1.5	2.3	3.3	1.8	-0.4	-1.5	1.8
Medication: Paracetamol	4.1	6.4	8.7	3.0	-2.3	-2.2	2.6
Medication: Lisinopril	0.9	1.1	3.0	0.9	1.7	-0.8	-0.3
Medication: Atorvastatin	1.1	1.3	2.5	1.5	0.3	-1.6	0.8
Illnesses of father: High blood pressure	0.2	0.2	0.3	-0.5	0.5	0.4	-0.4
Alcohol drinker status: Never	0.2	0.2	0.4	0.6	0.4	-0.6	-0.0
Ever smoked	1.9	3.4	7.3	-2.2	-0.7	2.7	-0.9
Basal metabolic rate	0.2	0.9	1.9	0.3	1.4	-1.1	0.7
Leg fat percentage (left)	3.7	13.5	39.7	1.7	-6.3	-1.4	3.1
Arm fat-free mass (left)	0.3	1.3	1.8	1.0	0.8	-1.3	1.4
Number of operations (self-reported)	1.2	1.9	5.9	0.9	-2.4	-0.5	0.7
Average weekly beer plus cider intake	0.5	0.7	1.0	0.9	0.5	-0.7	1.0
Irritability	0.2	0.3	0.7	0.1	0.6	-0.3	0.8
Risk taking	0.8	1.2	2.0	1.1	0.4	-1.2	1.4
Ever had prostate specific antigen (PSA) test	1.7	1.9	2.5	1.3	-1.4	-1.6	1.3
Fractured/broken bones in last 5 years	2.0	2.6	4.3	2.1	-0.1	-2.1	1.3
Age started oral contraceptive pill	0.2	0.3	1.0	-0.2	-1.0	-0.1	-0.1
Diastolic blood pressure, automated reading	1.0	3.0	6.2	1.4	-2.5	-0.4	1.9
Ever depressed for a whole week	2.5	3.1	3.4	1.8	-1.7	-1.8	1.6
Unable to work because of sickness or disability	3.0	3.9	5.1	2.1	-1.3	-2.1	2.3
Commuting to job workplace: Cycle	0.0	0.1	0.2	-0.4	0.1	0.1	-0.1
Myopia	0.3	0.5	1.2	-1.1	0.7	0.3	-0.4
Vascular/heart problems diagnosed by doctor	1.4	3.8	6.9	-2.6	-1.0	1.8	-2.1
Cholesterol lowering medication	0.7	1.0	1.2	1.0	1.1	-1.1	0.7
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	2.0	1.0	-1.4	-0.5	1.1
Pain experienced in last month	3.6	6.0	9.6	-2.4	3.1	2.1	-2.1
Supplements: Calcium	0.7	0.8	2.4	-0.5	-1.5	0.7	-0.2
Basal cell carcinoma (self-reported)	0.4	0.4	0.8	-0.9	-0.3	0.6	-0.7
Heart attack/myocardial infarction (self-reported)	1.7	2.1	3.7	1.6	-1.0	-1.2	1.9
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.4	-0.4	-0.3	0.5	-0.6
Heart disease (siblings)	0.1	0.1	0.2	-0.2	0.3	-0.2	-0.4
Alcohol drinker status: Previous	0.1	0.1	0.5	0.3	-0.7	-0.2	0.1
Pack years of smoking	2.7	4.0	6.5	1.5	-2.0	-1.8	2.5
Impedance of whole body	0.4	2.3	5.4	-1.7	0.7	2.3	-0.5
Leg fat mass (left)	2.2	8.8	21.0	1.6	-4.6	-1.7	2.9
Arm predicted mass (left)	0.3	1.4	1.9	1.0	0.8	-1.4	1.4