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chr20:24,230,055-26,307,797

Best TWAS P=7.48e-15 · Best GWAS P=7.61e-13 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ABHD12	0.10	0.17	blup	405	0.17	1.7e-20	7.0	7.8	8.9e-15	0.91	0.07	0.93	FALSE
2	CommonMind	Brain Pre-frontal Cortex	NINL	0.19	0.17	lasso	20	0.23	1.2e-27	7.0	7.8	7.5e-15	0.86	0.08	0.92	TRUE
3	CommonMind	Brain Pre-frontal Cortex	PYGB	0.10	0.05	lasso	3	0.05	6.9e-07	5.0	-5.5	4.7e-08	-0.33	0.90	0.01	FALSE
4	GTEx	Adipose Visceral Omentum	ABHD12	0.06	0.00	lasso	8	0.00	4.6e-01	7.0	7.0	3.3e-12	0.88	0.08	0.68	FALSE
5	GTEx	Artery Aorta	ABHD12	0.06	0.03	enet	6	0.03	5.4e-03	6.7	6.3	3.0e-10	0.90	0.09	0.87	FALSE
6	GTEx	Artery Aorta	NINL	0.17	0.18	lasso	6	0.19	1.5e-10	7.0	7.4	1.5e-13	0.95	0.06	0.94	FALSE
7	GTEx	Artery Tibial	ABHD12	0.12	0.12	enet	25	0.15	7.1e-12	6.6	6.8	1.2e-11	0.91	0.13	0.87	FALSE
8	GTEx	Artery Tibial	ENTPD6	0.24	0.12	lasso	9	0.17	2.1e-13	6.3	-5.7	1.3e-08	-0.75	0.26	0.74	FALSE
9	GTEx	Brain Caudate basal ganglia	ABHD12	0.09	0.05	enet	13	0.04	2.9e-02	7.0	7.1	1.6e-12	0.96	0.08	0.76	FALSE
10	GTEx	Brain Cerebellar Hemisphere	PYGB	0.20	0.16	lasso	5	0.12	5.8e-04	6.4	-6.2	6.1e-10	-0.88	0.08	0.75	FALSE
11	GTEx	Brain Cerebellar Hemisphere	NINL	0.17	0.07	enet	18	0.11	1.1e-03	6.7	5.8	5.1e-09	0.77	0.08	0.69	FALSE
12	GTEx	Brain Cerebellar Hemisphere	ENTPD6	0.22	0.26	lasso	3	0.17	3.8e-05	6.4	-6.4	1.9e-10	-0.94	0.12	0.87	FALSE
13	GTEx	Brain Cerebellum	ENTPD6	0.15	0.23	enet	8	0.14	4.6e-05	5.6	-5.9	4.2e-09	-0.88	0.18	0.78	TRUE
14	GTEx	Brain Cortex	ABHD12	0.08	0.11	lasso	8	0.09	1.4e-03	7.1	6.8	9.7e-12	0.94	0.06	0.78	FALSE
15	GTEx	Breast Mammary Tissue	CST7	0.10	0.00	lasso	4	0.00	7.3e-01	-5.3	5.9	2.8e-09	0.79	0.07	0.68	FALSE
16	GTEx	Breast Mammary Tissue	ABHD12	0.08	0.09	lasso	5	0.09	3.3e-05	7.0	7.0	2.0e-12	0.92	0.09	0.87	FALSE
17	GTEx	Breast Mammary Tissue (Male)	ABHD12	0.06	0.01	lasso	3	0.02	1.3e-01	5.6	6.4	1.7e-10	0.70	0.05	0.17	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	PYGB	0.38	0.08	lasso	5	0.06	7.0e-03	6.1	6.0	1.9e-09	0.75	0.10	0.78	TRUE
19	GTEx	Cells Transformed fibroblasts	ABHD12	0.24	0.33	lasso	4	0.35	6.3e-27	7.1	7.2	7.7e-13	0.98	0.06	0.94	FALSE
20	GTEx	Cells Transformed fibroblasts	GINS1	0.04	0.01	lasso	3	0.01	5.2e-02	2.8	5.2	1.7e-07	0.83	0.13	0.78	FALSE
21	GTEx	Colon Sigmoid	ABHD12	0.17	0.17	lasso	15	0.17	1.0e-06	6.5	6.6	4.2e-11	0.90	0.10	0.89	TRUE
22	GTEx	Esophagus Gastroesophageal Junction	ABHD12	0.15	0.14	lasso	13	0.14	7.0e-06	6.4	6.3	3.0e-10	0.96	0.07	0.93	FALSE
23	GTEx	Esophagus Mucosa	ENTPD6	0.09	0.04	enet	20	0.06	4.2e-05	7.0	-5.9	3.0e-09	-0.87	0.09	0.91	FALSE
24	GTEx	Esophagus Muscularis	ABHD12	0.10	0.10	enet	42	0.09	4.5e-06	7.0	6.1	9.1e-10	0.87	0.07	0.93	FALSE
25	GTEx	Esophagus Muscularis	ENTPD6	0.16	0.03	lasso	5	0.05	7.3e-04	4.7	-5.3	9.2e-08	-0.81	0.12	0.56	FALSE
26	GTEx	Heart Atrial Appendage	ABHD12	0.07	0.06	enet	16	0.06	1.0e-03	7.0	6.9	3.7e-12	0.97	0.07	0.92	FALSE
27	GTEx	Heart Left Ventricle	ABHD12	0.15	0.14	lasso	10	0.12	4.0e-07	7.2	7.4	1.7e-13	0.99	0.06	0.94	FALSE
28	GTEx	Heart Left Ventricle	NINL	0.08	0.03	enet	11	0.05	1.1e-03	6.6	6.3	3.3e-10	0.74	0.26	0.59	FALSE
29	GTEx	Liver	ABHD12	0.20	0.20	lasso	19	0.15	7.3e-05	7.0	6.9	4.4e-12	0.97	0.08	0.92	FALSE
30	GTEx	Liver	APMAP	0.20	-0.01	lasso	9	0.00	3.8e-01	7.0	5.6	2.4e-08	0.67	0.08	0.63	TRUE
31	GTEx	Lung	ABHD12	0.06	0.00	lasso	6	0.00	2.7e-01	6.3	7.0	3.0e-12	0.67	0.12	0.65	FALSE
32	GTEx	Lung	NINL	0.07	0.05	lasso	4	0.04	5.3e-04	-5.0	-6.2	4.2e-10	-0.86	0.08	0.91	FALSE
33	GTEx	Muscle Skeletal	ENTPD6	0.04	0.02	lasso	4	0.01	1.5e-02	5.7	-6.0	1.5e-09	-0.90	0.09	0.85	FALSE
34	GTEx	Nerve Tibial	PYGB	0.26	0.15	enet	11	0.14	5.7e-10	5.4	-5.8	8.0e-09	-0.64	0.97	0.03	FALSE
35	GTEx	Nerve Tibial	ABHD12	0.24	0.44	lasso	11	0.44	5.1e-34	7.0	-6.8	9.2e-12	-0.98	0.07	0.93	FALSE
36	GTEx	Ovary	ABHD12	0.23	0.04	lasso	8	0.05	1.9e-02	7.0	5.6	2.3e-08	0.87	0.07	0.69	FALSE
37	GTEx	Pancreas	ENTPD6	0.11	0.05	enet	23	0.05	5.0e-03	6.3	-7.1	8.9e-13	-0.77	0.09	0.85	FALSE
38	GTEx	Pituitary	ABHD12	0.27	0.31	enet	25	0.31	1.8e-08	7.0	7.5	7.1e-14	0.92	0.08	0.92	FALSE
39	GTEx	Skin Not Sun Exposed Suprapubic	PYGB	0.12	0.13	enet	13	0.14	4.2e-08	5.1	-5.6	1.7e-08	-0.53	0.56	0.28	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	ENTPD6	0.12	0.09	lasso	2	0.07	1.1e-04	5.4	-5.4	5.8e-08	-0.64	0.18	0.44	FALSE
41	GTEx	Skin Sun Exposed Lower leg	PYGB	0.11	0.10	lasso	4	0.09	1.2e-07	4.7	-5.1	3.0e-07	-0.59	0.87	0.12	FALSE
42	GTEx	Skin Sun Exposed Lower leg	ABHD12	0.07	0.03	lasso	10	0.05	7.3e-05	5.6	6.9	4.0e-12	0.92	0.13	0.85	FALSE
43	GTEx	Spleen	PYGB	0.15	0.09	lasso	6	0.04	2.6e-02	7.0	6.6	5.4e-11	0.95	0.08	0.83	FALSE
44	GTEx	Testis	ABHD12	0.21	0.18	enet	25	0.23	1.1e-10	7.0	7.1	1.0e-12	0.92	0.06	0.94	FALSE
45	GTEx	Thyroid	PYGB	0.10	0.09	lasso	2	0.09	4.4e-07	5.4	-5.3	1.4e-07	-0.57	0.89	0.09	TRUE
46	GTEx	Thyroid	ABHD12	0.05	0.04	lasso	5	0.03	3.9e-03	7.0	-7.0	3.3e-12	-0.98	0.08	0.90	FALSE
47	GTEx	Thyroid	NINL	0.13	0.18	enet	17	0.20	6.2e-15	-4.6	-7.0	2.1e-12	-0.84	0.41	0.59	FALSE
48	GTEx	Thyroid	VN1R108P	0.05	0.01	lasso	2	0.02	1.8e-02	3.1	5.6	2.4e-08	0.86	0.08	0.77	FALSE
49	GTEx	Whole Blood	PYGB	0.17	0.14	enet	22	0.18	2.7e-16	7.0	5.5	3.6e-08	0.90	0.09	0.91	FALSE
50	NTR	Blood	PYGB	0.07	0.10	enet	22	0.12	3.6e-36	7.1	5.6	2.3e-08	0.93	0.06	0.94	FALSE
51	ROSMAP	Brain Pre-frontal Cortex	PYGB	0.20	0.10	bslmm	414	0.11	3.2e-14	5.8	-6.8	1.3e-11	-0.65	0.54	0.46	FALSE
52	ROSMAP	Brain Pre-frontal Cortex	ABHD12	0.26	0.35	enet	35	0.42	7.9e-58	6.6	6.8	8.6e-12	0.86	0.09	0.91	FALSE
53	ROSMAP	Brain Pre-frontal Cortex	NINL	0.19	0.19	enet	18	0.25	2.1e-32	7.0	6.5	7.8e-11	0.86	0.06	0.94	FALSE
54	ROSMAP	Brain Pre-frontal Cortex	ENTPD6	0.32	0.10	bslmm	432	0.12	1.8e-15	6.3	7.0	3.1e-12	0.21	0.89	0.11	TRUE
55	YFS	Blood	ABHD12	0.15	0.35	bslmm	390	0.34	2.2e-118	7.1	7.3	2.9e-13	0.98	0.06	0.94	TRUE
56	YFS	Blood	NINL	0.04	0.03	lasso	8	0.03	2.8e-10	6.0	5.9	4.4e-09	0.46	0.99	0.01	FALSE
57	YFS	Blood	PYGB	0.36	0.49	enet	50	0.56	7.4e-226	5.8	5.5	3.8e-08	0.93	0.26	0.74	FALSE
58	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ABHD12	0.04	0.00	blup	77	0.02	6.6e-03	7.0	6.4	1.2e-10	0.93	0.04	0.53	FALSE
59	The Cancer Genome Atlas	Breast Invasive Carcinoma	PYGB	0.08	0.02	enet	7	0.03	1.7e-07	5.6	-5.7	1.1e-08	-0.54	0.89	0.08	FALSE
60	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PYGB	0.08	0.04	blup	74	0.06	1.0e-03	7.0	-7.0	3.4e-12	-0.93	0.04	0.86	FALSE
61	The Cancer Genome Atlas	Colon Adenocarcinoma	NINL	0.20	0.06	lasso	4	0.08	2.7e-05	5.1	6.2	4.6e-10	0.59	0.26	0.50	FALSE
62	The Cancer Genome Atlas	Esophageal Carcinoma	LOC100134868	0.14	0.11	lasso	2	0.10	4.6e-04	-5.6	-5.5	4.1e-08	-0.62	0.00	0.91	FALSE
63	The Cancer Genome Atlas	Glioblastoma Multiforme	ABHD12	0.14	0.10	lasso	5	0.13	1.1e-04	6.5	6.8	1.2e-11	0.92	0.06	0.89	FALSE
64	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ABHD12	0.04	0.03	blup	77	0.04	4.0e-05	7.1	6.8	7.5e-12	0.96	0.05	0.95	FALSE
65	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GINS1	0.03	0.01	enet	13	0.02	4.3e-03	3.1	5.8	7.1e-09	0.84	0.03	0.66	FALSE
66	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ABHD12	0.03	0.01	blup	77	0.01	8.7e-03	4.7	6.8	8.3e-12	0.89	0.06	0.76	FALSE
67	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ENTPD6	0.29	0.17	lasso	4	0.18	1.0e-10	4.7	-5.8	7.3e-09	-0.83	0.02	0.98	FALSE
68	The Cancer Genome Atlas	Brain Lower Grade Glioma	ABHD12	0.04	0.06	blup	77	0.06	2.2e-07	7.0	7.2	7.4e-13	0.98	0.06	0.94	FALSE
69	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ABHD12	0.07	0.05	blup	77	0.05	2.4e-03	7.0	6.8	1.5e-11	0.97	0.05	0.85	FALSE
70	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ABHD12	0.08	0.09	blup	80	0.09	1.7e-06	7.0	6.8	1.0e-11	0.97	0.06	0.94	FALSE
71	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ENTPD6	0.07	0.07	lasso	1	0.04	9.2e-03	6.4	-6.4	2.1e-10	-0.95	0.01	0.88	FALSE
72	The Cancer Genome Atlas	Prostate Adenocarcinoma	ABHD12	0.03	0.02	lasso	4	0.03	5.8e-04	-6.3	6.6	3.8e-11	0.83	0.07	0.75	FALSE
73	The Cancer Genome Atlas	Prostate Adenocarcinoma	PYGB	0.21	0.13	enet	5	0.17	2.0e-17	4.7	-5.8	5.5e-09	-0.61	1.00	0.00	FALSE
74	The Cancer Genome Atlas	Testicular Germ Cell Tumors	NINL	0.11	0.03	blup	81	0.07	2.1e-03	-6.4	-6.5	7.5e-11	-0.95	0.03	0.72	FALSE
75	The Cancer Genome Atlas	Thyroid Carcinoma	ENTPD6	0.16	0.14	lasso	4	0.13	1.2e-12	6.4	-6.2	4.4e-10	-0.95	0.01	0.99	FALSE
76	The Cancer Genome Atlas	Thyroid Carcinoma	NINL	0.08	0.14	lasso	11	0.13	2.9e-12	7.0	-6.8	1.1e-11	-0.98	0.02	0.98	FALSE
77	The Cancer Genome Atlas	Thyroid Carcinoma	PYGB	0.10	0.08	lasso	7	0.07	1.4e-07	5.4	-6.1	8.9e-10	-0.62	0.88	0.12	FALSE