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chr17:44,788,310-47,718,188

Best TWAS P=1.06e-11 · Best GWAS P=2.01e-14 conditioned to 6.91e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
22	GTEx	Muscle Skeletal	AC003665.1	0.05	0.03	enet	8	0.03	1.4e-03	5.29	6.8	1.1e-11	0.63	0.12	0.72	TRUE
21	GTEx	Liver	ARL17A	0.34	0.18	lasso	9	0.18	9.8e-06	5.08	6.0	1.8e-09	-0.04	0.00	0.90	TRUE
32	YFS	Blood	UBE2Z	0.06	0.03	enet	19	0.06	1.5e-18	3.31	5.7	1.3e-08	0.10	1.00	0.00	TRUE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	CDK5RAP3	0.06	0.00	blup	62	0.03	1.0e-03	-3.42	-6.5	6.3e-11	-0.35	0.01	0.82	FALSE
11	GTEx	Brain Cerebellar Hemisphere	CDK5RAP3	0.22	0.10	lasso	6	0.09	2.6e-03	5.20	-6.4	1.4e-10	-0.74	0.08	0.40	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	CBX1	0.03	0.04	lasso	4	0.04	3.7e-05	6.50	-6.4	1.6e-10	-0.84	0.01	0.99	FALSE
28	GTEx	Testis	RP11-6N17.4	0.14	0.02	lasso	10	0.02	4.8e-02	6.45	6.3	2.3e-10	0.78	0.18	0.66	FALSE
15	GTEx	Brain Nucleus accumbens basal ganglia	CDK5RAP3	0.21	0.04	lasso	4	0.02	7.2e-02	6.45	-6.3	3.6e-10	-0.78	0.08	0.36	FALSE
25	GTEx	Pancreas	CDK5RAP3	0.11	-0.01	lasso	4	0.02	5.1e-02	5.20	-6.2	4.9e-10	-0.48	0.09	0.18	FALSE
27	GTEx	Stomach	RP11-6N17.9	0.13	0.02	lasso	6	0.04	8.0e-03	5.72	-6.1	8.4e-10	-0.70	0.12	0.69	FALSE
20	GTEx	Heart Atrial Appendage	CDK5RAP3	0.13	0.00	enet	18	0.04	5.1e-03	1.88	-6.1	8.6e-10	-0.42	0.09	0.05	FALSE
16	GTEx	Brain Nucleus accumbens basal ganglia	RP11-6N17.9	0.47	0.05	lasso	17	0.11	8.3e-04	5.62	-6.1	1.3e-09	-0.65	0.11	0.38	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CDK5RAP3	0.15	0.12	bslmm	392	0.14	3.6e-16	6.16	-6.1	1.4e-09	-0.78	0.90	0.10	FALSE
10	GTEx	Brain Caudate basal ganglia	RP11-6N17.9	0.45	-0.01	enet	28	0.16	3.3e-05	-0.74	-6.0	1.6e-09	-0.48	0.06	0.13	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	RP11-6N17.9	0.18	0.14	lasso	3	0.09	4.9e-04	-4.46	-6.0	2.6e-09	-0.49	0.03	0.73	FALSE
18	GTEx	Esophagus Gastroesophageal Junction	CDK5RAP3	0.21	0.09	lasso	6	0.07	1.2e-03	-4.46	-5.9	3.2e-09	-0.30	0.09	0.50	FALSE
12	GTEx	Brain Cerebellar Hemisphere	RP11-6N17.10	0.21	0.16	lasso	5	0.13	3.8e-04	5.20	-5.9	4.8e-09	-0.73	0.09	0.43	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	CDK5RAP3	0.05	0.03	lasso	2	0.02	1.8e-05	5.72	-5.8	6.2e-09	-0.76	0.00	1.00	FALSE
34	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CBX1	0.03	0.01	lasso	3	0.01	8.7e-03	6.45	-5.8	8.4e-09	-0.80	0.01	0.81	FALSE
7	GTEx	Artery Aorta	RP11-6N17.10	0.20	0.07	enet	24	0.14	3.5e-08	-4.46	-5.8	8.9e-09	-0.43	0.50	0.12	FALSE
26	GTEx	Pancreas	RP11-6N17.9	0.15	0.04	lasso	5	0.04	9.3e-03	-2.05	-5.7	1.0e-08	-0.47	0.13	0.17	FALSE
31	GTEx	Thyroid	RP11-6N17.10	0.19	0.12	lasso	5	0.13	3.0e-10	-4.46	-5.7	1.0e-08	-0.47	1.00	0.00	FALSE
29	GTEx	Thyroid	CDK5RAP3	0.21	0.14	lasso	5	0.18	1.6e-13	-4.46	-5.7	1.3e-08	-0.51	1.00	0.00	FALSE
3	GTEx	Adipose Subcutaneous	RP11-6N17.9	0.10	0.05	enet	14	0.05	6.8e-05	-3.31	-5.6	2.2e-08	-0.42	0.46	0.06	FALSE
13	GTEx	Brain Cortex	ARL17A	0.35	0.20	lasso	6	0.25	1.7e-07	5.08	5.6	2.6e-08	-0.05	0.00	0.95	FALSE
30	GTEx	Thyroid	RP11-6N17.9	0.22	0.14	lasso	5	0.14	5.2e-11	-4.46	-5.6	2.8e-08	-0.44	1.00	0.00	FALSE
6	GTEx	Artery Aorta	RP11-6N17.9	0.23	0.12	enet	19	0.19	9.5e-11	-4.46	-5.5	4.7e-08	-0.42	0.99	0.00	FALSE
38	The Cancer Genome Atlas	Thyroid Carcinoma	ATP5G1	0.19	0.03	lasso	3	0.08	4.4e-08	4.21	5.4	6.6e-08	0.08	0.01	0.97	FALSE
23	GTEx	Nerve Tibial	CDK5RAP3	0.41	0.35	enet	23	0.36	6.1e-27	-4.46	-5.4	7.6e-08	-0.41	1.00	0.00	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SNF8	0.08	0.07	lasso	5	0.08	9.3e-10	-4.48	5.3	9.5e-08	0.07	0.10	0.90	FALSE
14	GTEx	Brain Nucleus accumbens basal ganglia	KPNB1	0.24	0.00	lasso	9	0.01	2.1e-01	0.80	-5.3	1.1e-07	-0.80	0.02	0.79	FALSE
37	The Cancer Genome Atlas	Soft Tissue Sarcoma	LRRC37A2	0.43	0.26	enet	22	0.37	3.8e-23	-3.30	-5.3	1.2e-07	-0.04	0.36	0.14	FALSE
24	GTEx	Nerve Tibial	RP11-6N17.10	0.28	0.19	lasso	8	0.19	1.6e-13	-4.46	-5.3	1.3e-07	-0.36	1.00	0.00	FALSE
5	GTEx	Artery Aorta	CDK5RAP3	0.26	0.22	lasso	11	0.25	5.8e-14	-4.46	-5.2	2.1e-07	-0.35	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	RP11-6N17.9	0.13	0.04	enet	16	0.05	8.4e-04	-1.82	-5.1	2.7e-07	-0.47	0.26	0.30	FALSE
8	GTEx	Artery Coronary	PNPO	0.13	0.00	lasso	4	-0.01	5.9e-01	4.72	5.1	2.7e-07	0.24	0.13	0.06	FALSE
9	GTEx	Artery Tibial	ARL17A	0.69	0.37	lasso	9	0.44	5.4e-38	5.08	5.1	2.8e-07	-0.07	0.00	1.00	FALSE
17	GTEx	Cells EBV-transformed lymphocytes	NSF	0.20	0.07	lasso	2	0.10	3.4e-04	4.80	-5.1	3.0e-07	-0.04	0.03	0.70	FALSE