[Hub]/) : Traits : Whole body fat mass : ← →

chr20:24,230,055-26,253,682

Best TWAS P=3.57e-15 · Best GWAS P=9.49e-12 conditioned to 8.53e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ABHD12	0.10	0.17	blup	405	0.17	1.7e-20	6.7	7.9	3.6e-15	0.92	0.07	0.93	TRUE
19	GTEx	Breast Mammary Tissue (Male)	CST7	0.15	0.00	lasso	4	0.03	7.0e-02	-4.0	-5.5	3.2e-08	-0.16	0.06	0.10	TRUE
2	CommonMind	Brain Pre-frontal Cortex	NINL	0.19	0.17	lasso	20	0.23	1.2e-27	6.7	7.9	3.7e-15	0.87	0.08	0.92	FALSE
56	ROSMAP	Brain Pre-frontal Cortex	ENTPD6	0.32	0.10	bslmm	432	0.12	1.8e-15	6.5	7.7	9.2e-15	0.19	0.14	0.86	FALSE
41	GTEx	Pituitary	ABHD12	0.27	0.31	enet	25	0.31	1.8e-08	6.7	7.4	1.6e-13	0.94	0.08	0.92	FALSE
6	GTEx	Artery Aorta	NINL	0.17	0.18	lasso	6	0.19	1.5e-10	6.7	7.3	3.1e-13	0.96	0.07	0.93	FALSE
34	GTEx	Lung	ABHD12	0.06	0.00	lasso	6	0.00	2.7e-01	6.5	7.2	5.4e-13	0.68	0.10	0.71	FALSE
30	GTEx	Heart Left Ventricle	ABHD12	0.15	0.14	lasso	10	0.12	4.0e-07	6.8	7.2	6.8e-13	0.99	0.06	0.94	FALSE
45	GTEx	Skin Sun Exposed Lower leg	ABHD12	0.07	0.03	lasso	10	0.05	7.3e-05	5.9	7.1	1.5e-12	0.93	0.13	0.85	FALSE
57	YFS	Blood	ABHD12	0.15	0.35	bslmm	390	0.34	2.2e-118	6.8	7.0	1.8e-12	0.99	0.06	0.94	FALSE
40	GTEx	Pancreas	ENTPD6	0.11	0.05	enet	23	0.05	5.0e-03	6.5	-7.0	2.5e-12	-0.78	0.09	0.85	FALSE
47	GTEx	Testis	ABHD12	0.21	0.18	enet	25	0.23	1.1e-10	6.7	7.0	2.8e-12	0.94	0.07	0.93	FALSE
18	GTEx	Breast Mammary Tissue	ABHD12	0.08	0.09	lasso	5	0.09	3.3e-05	6.7	6.9	3.8e-12	0.94	0.09	0.87	FALSE
4	GTEx	Adipose Visceral Omentum	ABHD12	0.06	0.00	lasso	8	0.00	4.6e-01	6.7	6.9	4.7e-12	0.89	0.08	0.67	FALSE
62	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PYGB	0.08	0.04	blup	74	0.06	1.0e-03	6.7	-6.9	4.9e-12	-0.94	0.04	0.86	FALSE
72	The Cancer Genome Atlas	Brain Lower Grade Glioma	ABHD12	0.04	0.06	blup	77	0.06	2.2e-07	6.7	6.9	5.3e-12	0.99	0.06	0.94	FALSE
22	GTEx	Cells Transformed fibroblasts	ABHD12	0.24	0.33	lasso	4	0.35	6.3e-27	6.8	6.9	6.6e-12	0.99	0.06	0.94	FALSE
54	ROSMAP	Brain Pre-frontal Cortex	ABHD12	0.26	0.35	enet	35	0.42	7.9e-58	6.4	6.8	9.1e-12	0.88	0.10	0.90	FALSE
10	GTEx	Brain Caudate basal ganglia	ABHD12	0.09	0.05	enet	13	0.04	2.9e-02	6.7	6.8	1.2e-11	0.98	0.08	0.76	FALSE
53	ROSMAP	Brain Pre-frontal Cortex	PYGB	0.20	0.10	bslmm	414	0.11	3.2e-14	6.3	-6.8	1.2e-11	-0.66	0.29	0.71	FALSE
70	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ABHD12	0.03	0.01	blup	77	0.01	8.7e-03	5.0	6.8	1.3e-11	0.91	0.06	0.76	FALSE
49	GTEx	Thyroid	ABHD12	0.05	0.04	lasso	5	0.03	3.9e-03	6.7	-6.7	2.3e-11	-0.99	0.08	0.90	FALSE
20	GTEx	Breast Mammary Tissue (Male)	ABHD12	0.06	0.01	lasso	3	0.02	1.3e-01	5.8	6.6	3.2e-11	0.71	0.05	0.18	FALSE
32	GTEx	Liver	ABHD12	0.20	0.20	lasso	19	0.15	7.3e-05	6.7	6.6	3.6e-11	0.98	0.08	0.91	FALSE
7	GTEx	Artery Tibial	ABHD12	0.12	0.12	enet	25	0.15	7.1e-12	6.4	6.6	4.3e-11	0.93	0.13	0.87	FALSE
29	GTEx	Heart Atrial Appendage	ABHD12	0.07	0.06	enet	16	0.06	1.0e-03	6.7	6.6	5.2e-11	0.99	0.07	0.91	FALSE
50	GTEx	Thyroid	NINL	0.13	0.18	enet	17	0.20	6.2e-15	-4.0	-6.6	5.2e-11	-0.85	0.41	0.59	FALSE
68	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ABHD12	0.04	0.03	blup	77	0.04	4.0e-05	6.8	6.5	8.1e-11	0.97	0.05	0.95	FALSE
66	The Cancer Genome Atlas	Glioblastoma Multiforme	ABHD12	0.14	0.10	lasso	5	0.13	1.1e-04	6.2	6.5	8.2e-11	0.93	0.06	0.89	FALSE
80	The Cancer Genome Atlas	Thyroid Carcinoma	NINL	0.08	0.14	lasso	11	0.13	2.9e-12	6.7	-6.5	8.2e-11	-0.99	0.02	0.98	FALSE
63	The Cancer Genome Atlas	Colon Adenocarcinoma	NINL	0.20	0.06	lasso	4	0.08	2.7e-05	5.6	6.5	8.8e-11	0.60	0.10	0.80	FALSE
38	GTEx	Nerve Tibial	ABHD12	0.24	0.44	lasso	11	0.44	5.1e-34	6.7	-6.5	9.2e-11	-0.99	0.08	0.92	FALSE
74	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ABHD12	0.08	0.09	blup	80	0.09	1.7e-06	6.6	6.5	1.1e-10	0.98	0.06	0.94	FALSE
81	The Cancer Genome Atlas	Thyroid Carcinoma	PYGB	0.10	0.08	lasso	7	0.07	1.4e-07	5.6	-6.4	1.3e-10	-0.64	0.52	0.48	FALSE
73	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ABHD12	0.07	0.05	blup	77	0.05	2.4e-03	6.7	6.4	1.4e-10	0.98	0.05	0.84	FALSE
76	The Cancer Genome Atlas	Prostate Adenocarcinoma	ABHD12	0.03	0.02	lasso	4	0.03	5.8e-04	-6.1	6.4	1.9e-10	0.84	0.07	0.75	FALSE
42	GTEx	Skin Not Sun Exposed Suprapubic	PYGB	0.12	0.13	enet	13	0.14	4.2e-08	5.6	-6.4	2.1e-10	-0.55	0.54	0.31	FALSE
16	GTEx	Brain Cortex	ABHD12	0.08	0.11	lasso	8	0.09	1.4e-03	6.8	6.3	2.3e-10	0.95	0.07	0.77	FALSE
58	YFS	Blood	NINL	0.04	0.03	lasso	8	0.03	2.8e-10	6.4	6.3	2.3e-10	0.48	0.34	0.66	FALSE
14	GTEx	Brain Cerebellar Hemisphere	ENTPD6	0.22	0.26	lasso	3	0.17	3.8e-05	6.2	-6.3	3.7e-10	-0.95	0.13	0.86	FALSE
55	ROSMAP	Brain Pre-frontal Cortex	NINL	0.19	0.19	enet	18	0.25	2.1e-32	6.7	6.2	4.2e-10	0.86	0.07	0.93	FALSE
23	GTEx	Colon Sigmoid	ABHD12	0.17	0.17	lasso	15	0.17	1.0e-06	6.2	6.2	4.4e-10	0.91	0.11	0.89	FALSE
75	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ENTPD6	0.07	0.07	lasso	1	0.04	9.2e-03	6.2	-6.2	5.7e-10	-0.96	0.03	0.62	FALSE
11	GTEx	Brain Cerebellar Hemisphere	PYGB	0.20	0.16	lasso	5	0.12	5.8e-04	6.2	-6.2	6.0e-10	-0.90	0.08	0.74	FALSE
24	GTEx	Esophagus Gastroesophageal Junction	ABHD12	0.15	0.14	lasso	13	0.14	7.0e-06	6.2	6.2	6.2e-10	0.97	0.07	0.92	FALSE
79	The Cancer Genome Atlas	Thyroid Carcinoma	ENTPD6	0.16	0.14	lasso	4	0.13	1.2e-12	6.2	-6.2	6.9e-10	-0.96	0.05	0.95	FALSE
78	The Cancer Genome Atlas	Testicular Germ Cell Tumors	NINL	0.11	0.03	blup	81	0.07	2.1e-03	-6.2	-6.2	7.4e-10	-0.96	0.03	0.71	FALSE
33	GTEx	Liver	APMAP	0.20	-0.01	lasso	9	0.00	3.8e-01	6.7	6.1	7.9e-10	0.68	0.08	0.62	FALSE
61	The Cancer Genome Atlas	Breast Invasive Carcinoma	PYGB	0.08	0.02	enet	7	0.03	1.7e-07	6.1	-6.1	7.9e-10	-0.55	0.65	0.33	FALSE
46	GTEx	Spleen	PYGB	0.15	0.09	lasso	6	0.04	2.6e-02	6.7	6.1	8.6e-10	0.96	0.08	0.82	FALSE
60	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ABHD12	0.04	0.00	blup	77	0.02	6.6e-03	6.6	6.1	8.6e-10	0.93	0.04	0.53	FALSE
15	GTEx	Brain Cerebellum	ENTPD6	0.15	0.23	enet	8	0.14	4.6e-05	5.9	-6.1	1.0e-09	-0.89	0.18	0.78	FALSE
31	GTEx	Heart Left Ventricle	NINL	0.08	0.03	enet	11	0.05	1.1e-03	6.4	6.1	1.3e-09	0.75	0.25	0.61	FALSE
37	GTEx	Nerve Tibial	PYGB	0.26	0.15	enet	11	0.14	5.7e-10	5.6	-6.0	1.7e-09	-0.66	0.95	0.05	FALSE
77	The Cancer Genome Atlas	Prostate Adenocarcinoma	PYGB	0.21	0.13	enet	5	0.17	2.0e-17	5.0	-6.0	1.7e-09	-0.63	0.99	0.01	FALSE
3	CommonMind	Brain Pre-frontal Cortex	PYGB	0.10	0.05	lasso	3	0.05	6.9e-07	5.4	-5.9	2.8e-09	-0.34	0.66	0.26	FALSE
21	GTEx	Cells EBV-transformed lymphocytes	PYGB	0.38	0.08	lasso	5	0.06	7.0e-03	6.1	5.9	2.9e-09	0.76	0.10	0.78	FALSE
26	GTEx	Esophagus Mucosa	ENTPD6	0.09	0.04	enet	20	0.06	4.2e-05	6.7	-5.9	4.0e-09	-0.88	0.09	0.90	FALSE
5	GTEx	Artery Aorta	ABHD12	0.06	0.03	enet	6	0.03	5.4e-03	6.5	5.9	4.3e-09	0.91	0.09	0.86	FALSE
71	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ENTPD6	0.29	0.17	lasso	4	0.18	1.0e-10	5.0	-5.9	4.5e-09	-0.85	0.08	0.92	FALSE
27	GTEx	Esophagus Muscularis	ABHD12	0.10	0.10	enet	42	0.09	4.5e-06	6.7	5.9	4.6e-09	0.87	0.08	0.92	FALSE
17	GTEx	Breast Mammary Tissue	CST7	0.10	0.00	lasso	4	0.00	7.3e-01	-5.3	5.8	6.1e-09	0.80	0.07	0.68	FALSE
12	GTEx	Brain Cerebellar Hemisphere	NINL	0.17	0.07	enet	18	0.11	1.1e-03	6.5	5.7	1.1e-08	0.77	0.08	0.69	FALSE
35	GTEx	Lung	NINL	0.07	0.05	lasso	4	0.04	5.3e-04	-4.4	-5.7	1.1e-08	-0.87	0.09	0.90	FALSE
9	GTEx	Artery Tibial	ENTPD6	0.24	0.12	lasso	9	0.17	2.1e-13	6.5	-5.7	1.3e-08	-0.77	0.15	0.85	FALSE
43	GTEx	Skin Not Sun Exposed Suprapubic	ENTPD6	0.12	0.09	lasso	2	0.07	1.1e-04	5.6	-5.6	2.5e-08	-0.66	0.18	0.45	FALSE
36	GTEx	Muscle Skeletal	ENTPD6	0.04	0.02	lasso	4	0.01	1.5e-02	5.3	-5.5	3.4e-08	-0.90	0.10	0.84	FALSE
44	GTEx	Skin Sun Exposed Lower leg	PYGB	0.11	0.10	lasso	4	0.09	1.2e-07	5.0	-5.5	4.0e-08	-0.61	0.85	0.14	FALSE
48	GTEx	Thyroid	PYGB	0.10	0.09	lasso	2	0.09	4.4e-07	5.6	-5.5	4.7e-08	-0.59	0.87	0.11	FALSE
13	GTEx	Brain Cerebellar Hemisphere	ACSS1	0.31	0.24	lasso	3	0.16	7.1e-05	-5.2	-5.4	5.1e-08	-0.29	0.19	0.06	FALSE
51	GTEx	Whole Blood	PYGB	0.17	0.14	enet	22	0.18	2.7e-16	6.7	5.4	5.1e-08	0.90	0.09	0.91	FALSE
52	NTR	Blood	PYGB	0.07	0.10	enet	22	0.12	3.6e-36	6.8	5.4	6.0e-08	0.94	0.06	0.94	FALSE
65	The Cancer Genome Atlas	Esophageal Carcinoma	LOC100134868	0.14	0.11	lasso	2	0.10	4.6e-04	-5.6	-5.4	6.0e-08	-0.63	0.00	0.91	FALSE
69	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GINS1	0.03	0.01	enet	13	0.02	4.3e-03	2.5	5.3	9.6e-08	0.84	0.03	0.66	FALSE
28	GTEx	Esophagus Muscularis	ENTPD6	0.16	0.03	lasso	5	0.05	7.3e-04	5.0	-5.3	1.1e-07	-0.83	0.12	0.56	FALSE
67	The Cancer Genome Atlas	Glioblastoma Multiforme	VSX1	0.12	0.08	blup	46	0.05	1.2e-02	-4.6	5.3	1.4e-07	0.24	0.04	0.30	FALSE
39	GTEx	Ovary	ABHD12	0.23	0.04	lasso	8	0.05	1.9e-02	6.7	5.2	1.7e-07	0.89	0.08	0.68	FALSE
8	GTEx	Artery Tibial	NINL	0.58	0.05	lasso	12	0.11	6.0e-09	6.6	5.2	1.9e-07	0.36	0.21	0.78	FALSE
59	YFS	Blood	PYGB	0.36	0.49	enet	50	0.56	7.4e-226	5.9	5.2	2.1e-07	0.93	0.28	0.72	FALSE
64	The Cancer Genome Atlas	Colon Adenocarcinoma	PYGB	0.09	0.07	lasso	3	0.06	3.4e-04	5.0	-5.2	2.2e-07	-0.63	0.06	0.66	FALSE
25	GTEx	Esophagus Mucosa	NANP	0.07	0.00	lasso	7	0.01	5.1e-02	5.9	-5.1	2.6e-07	-0.74	0.08	0.53	FALSE