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chr20:31,382,860-35,512,648

Best TWAS P=4.37e-10 · Best GWAS P=1.73e-10 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
25	YFS	Blood	EIF2S2	0.07	0.07	enet	25	0.06	4.3e-20	-5.3	6.2	4.4e-10	0.22	0.04	0.96	TRUE
4	CommonMind	Brain Pre-frontal Cortex	UQCC	0.07	0.04	lasso	2	0.05	1.4e-06	5.1	-5.7	1.1e-08	-0.53	0.53	0.47	TRUE
28	The Cancer Genome Atlas	Breast Invasive Carcinoma	UQCC	0.08	0.11	blup	67	0.12	1.1e-22	5.0	-5.7	1.3e-08	-0.42	0.61	0.39	TRUE
2	CommonMind	Brain Pre-frontal Cortex	E2F1	0.06	0.01	bslmm	268	0.02	1.6e-03	-4.9	5.6	2.6e-08	0.05	0.14	0.18	TRUE
14	GTEx	Colon Transverse	UQCC1	0.11	0.01	lasso	4	0.01	1.0e-01	6.4	-5.5	5.0e-08	-0.86	0.02	0.82	TRUE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	NCOA6	0.04	0.02	blup	65	0.04	6.1e-05	-3.9	-5.4	6.2e-08	-0.25	0.23	0.40	TRUE
11	GTEx	Breast Mammary Tissue	ITCH	0.09	0.04	enet	28	0.09	2.5e-05	4.1	-5.2	2.0e-07	-0.42	0.20	0.77	TRUE
39	The Cancer Genome Atlas	Stomach Adenocarcinoma	GDF5	0.09	0.04	enet	13	0.05	2.4e-04	5.9	5.2	2.0e-07	0.31	0.00	0.99	TRUE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	GGT7	0.02	0.02	lasso	3	0.02	2.2e-04	5.2	-5.2	2.4e-07	-0.30	0.06	0.54	TRUE
6	GTEx	Artery Aorta	GGT7	0.06	0.00	enet	7	0.02	1.9e-02	-4.9	6.2	6.0e-10	0.42	0.15	0.37	FALSE
37	The Cancer Genome Atlas	Prostate Adenocarcinoma	GGT7	0.05	0.02	enet	6	0.03	3.3e-04	5.8	-6.2	7.7e-10	-0.46	0.01	0.96	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	EDEM2	0.17	0.00	lasso	4	0.00	2.7e-01	5.7	-6.0	1.7e-09	-0.52	0.07	0.38	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	NCOA6	0.11	0.06	enet	15	0.06	3.9e-03	5.4	-6.0	1.7e-09	-0.70	0.10	0.63	FALSE
22	GTEx	Thyroid	MYH7B	0.06	0.03	enet	15	0.06	3.6e-05	5.6	5.9	3.4e-09	0.74	0.05	0.94	FALSE
34	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	UQCC	0.12	0.03	blup	67	0.09	1.7e-04	5.0	-5.6	2.1e-08	-0.43	0.12	0.43	FALSE
35	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	UQCC	0.22	0.21	lasso	7	0.18	1.9e-07	5.0	-5.6	2.4e-08	-0.39	0.59	0.40	FALSE
29	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UQCC	0.09	0.10	blup	67	0.10	7.2e-11	5.1	-5.5	3.2e-08	-0.41	0.62	0.38	FALSE
9	GTEx	Brain Frontal Cortex BA9	UQCC1	0.16	0.07	lasso	3	0.08	3.7e-03	5.1	-5.5	3.5e-08	-0.37	0.12	0.12	FALSE
30	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	UQCC	0.08	0.01	lasso	3	0.01	9.0e-02	4.9	-5.5	4.5e-08	-0.52	0.14	0.46	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	UQCC	0.15	0.21	blup	67	0.22	1.2e-20	5.0	-5.5	4.6e-08	-0.50	0.60	0.40	FALSE
17	GTEx	Muscle Skeletal	CBFA2T2	0.05	0.01	enet	15	0.01	2.0e-02	-4.5	5.4	6.7e-08	0.03	0.44	0.35	FALSE
18	GTEx	Muscle Skeletal	ACSS2	0.04	0.04	enet	12	0.04	3.1e-05	5.2	5.4	6.8e-08	0.42	0.20	0.77	FALSE
38	The Cancer Genome Atlas	Prostate Adenocarcinoma	UQCC	0.07	0.10	lasso	8	0.11	1.3e-11	5.0	-5.4	7.0e-08	-0.40	0.58	0.42	FALSE
20	GTEx	Skin Sun Exposed Lower leg	UQCC1	0.19	0.13	enet	16	0.10	8.1e-09	5.2	-5.4	7.9e-08	-0.38	0.59	0.41	FALSE
33	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GDF5	0.05	0.02	blup	76	0.04	1.4e-03	5.2	5.4	8.1e-08	0.46	0.03	0.92	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	GDF5	0.05	0.05	lasso	5	0.04	7.2e-05	5.9	5.4	8.6e-08	0.33	0.00	1.00	FALSE
3	CommonMind	Brain Pre-frontal Cortex	MMP24	0.02	0.00	bslmm	370	0.00	1.7e-01	4.9	5.4	8.7e-08	0.57	0.03	0.63	FALSE
21	GTEx	Stomach	MAP1LC3A	0.10	0.04	enet	10	0.05	1.3e-03	-4.3	5.3	1.3e-07	0.40	0.23	0.35	FALSE
5	GTEx	Adipose Subcutaneous	UQCC1	0.09	0.12	lasso	2	0.11	4.5e-09	5.2	-5.3	1.4e-07	-0.35	0.59	0.41	FALSE
12	GTEx	Breast Mammary Tissue (Female)	ITCH	0.09	0.02	enet	16	0.06	8.2e-03	-5.6	-5.3	1.4e-07	-0.32	0.09	0.57	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CEP250	0.02	0.00	blup	344	0.00	1.0e-01	2.9	-5.3	1.5e-07	-0.46	0.24	0.06	FALSE
19	GTEx	Nerve Tibial	UQCC1	0.07	0.04	enet	6	0.03	2.7e-03	5.2	-5.2	1.6e-07	-0.37	0.53	0.38	FALSE
23	NTR	Blood	UQCC	0.01	0.01	enet	6	0.00	1.6e-02	5.2	-5.2	1.6e-07	-0.37	0.26	0.30	FALSE
16	GTEx	Lung	UQCC1	0.13	0.08	lasso	5	0.06	1.0e-05	5.2	-5.2	2.0e-07	-0.35	0.62	0.38	FALSE
26	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	UQCC	0.03	0.04	blup	67	0.03	2.6e-03	5.1	-5.2	2.2e-07	-0.41	0.08	0.52	FALSE
7	GTEx	Artery Tibial	TP53INP2	0.09	0.08	lasso	1	0.07	5.6e-06	5.2	5.2	2.4e-07	0.24	0.19	0.69	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	UQCC	0.04	0.06	lasso	6	0.05	2.3e-06	5.2	-5.2	2.5e-07	-0.33	0.59	0.41	FALSE
8	GTEx	Artery Tibial	EPB41L1	0.07	0.07	enet	10	0.07	1.8e-06	4.8	5.1	2.7e-07	0.30	0.01	0.96	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	GDF5	0.10	0.13	lasso	2	0.12	2.9e-15	5.1	5.1	2.7e-07	0.33	0.59	0.41	FALSE
15	GTEx	Esophagus Muscularis	ITCH	0.07	0.02	lasso	3	0.01	6.3e-02	5.3	-5.1	2.9e-07	-0.45	0.14	0.69	FALSE