Hub : Genes

GJC1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0980	0.0310	3.3e-06	0.037	0.037	0.027	0.035	0.001	2.3e-05	2.4e-05	2.6e-04	3.5e-05	2.5e-01
2	GTEx	Artery Aorta	0.2350	0.0590	2.6e-07	0.159	NA	0.137	NA	0.145	4.3e-09	NA	5.8e-08	NA	2.2e-08
3	GTEx	Artery Tibial	0.0999	0.0386	5.9e-04	0.045	NA	-0.002	NA	0.012	1.8e-04	NA	4.6e-01	NA	3.5e-02
4	GTEx	Brain Cerebellar Hemisphere	0.2350	0.0730	1.4e-04	0.148	NA	0.224	NA	0.239	1.3e-04	NA	1.9e-06	NA	8.1e-07
5	GTEx	Brain Cerebellum	0.3480	0.1030	9.9e-05	0.000	NA	0.028	NA	0.037	3.1e-01	NA	5.0e-02	NA	3.0e-02
6	GTEx	Brain Frontal Cortex BA9	0.2076	0.0945	7.3e-03	-0.010	NA	-0.009	NA	-0.002	7.5e-01	NA	7.0e-01	NA	3.6e-01
7	GTEx	Cells EBV-transformed lymphocytes	0.3400	0.0800	1.2e-05	0.326	NA	0.300	NA	0.327	2.3e-11	NA	2.0e-10	NA	2.3e-11
8	GTEx	Cells Transformed fibroblasts	0.4120	0.0500	0.0e+00	0.399	NA	0.438	NA	0.430	8.9e-32	NA	8.7e-36	NA	6.0e-35
9	GTEx	Heart Left Ventricle	0.1416	0.0530	9.0e-05	0.090	NA	0.092	NA	0.092	1.6e-05	NA	1.3e-05	NA	1.3e-05
10	TCGA	Head and Neck Squamous Cell Carcinoma	0.1676	0.0694	2.2e-05	0.022	0.052	0.060	NA	0.057	1.3e-03	1.4e-06	2.5e-07	NA	5.3e-07
11	TCGA	Liver Hepatocellular Carcinoma	0.1050	0.0550	3.1e-03	0.049	0.032	0.028	NA	0.042	2.4e-03	1.2e-02	1.7e-02	NA	4.4e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	1.0	1.6	4.3	-1.0	-1.9	-0.5	0.1	0.1	1.1	-2.0	-2.1	0.0	-1.4	0.9
Bipolar Disorder or Schizophrenia	0.2	0.5	1.5	-0.2	-1.2	0.4	0.3	0.4	-0.8	-1.1	-0.7	0.6	-0.7	-0.1
Depressed Affect (Nagel 2018)	0.5	1.1	5.1	0.2	-0.1	-1.4	1.1	1.0	0.6	-1.1	-0.7	0.2	-2.2	-0.7
Depression (Nagel 2018)	0.4	0.5	1.3	1.0	-1.1	-0.3	0.6	0.8	0.1	-1.1	-0.9	-0.4	-0.5	0.7
Intelligence (Savage-Jansen 2018)	1.2	3.8	15.0	-0.4	1.6	3.0	0.1	-0.9	0.1	2.7	2.1	1.1	3.9	1.0
Neuroticism (Nagel 2018)	0.6	1.4	4.0	-0.4	-0.5	-1.4	1.5	1.6	1.0	-1.5	-1.0	0.3	-2.0	0.2
Schizophrenia (2018)	0.3	0.6	3.6	0.5	-0.0	0.9	0.4	0.4	-1.9	0.2	0.7	0.8	0.2	-0.9
Schizophrenia vs Biploar Disorder	0.8	1.1	3.7	1.9	0.0	-0.9	0.6	0.9	-1.6	0.5	0.8	0.8	-0.5	-1.4
Worry (Nagel 2018)	0.6	1.3	5.9	0.1	0.1	-0.6	2.4	2.4	-0.1	-0.5	-0.3	1.1	-0.4	0.8
Alzheimer’s Disease (in mother)	2.0	2.4	6.7	-0.3	2.2	1.3	0.4	0.3	-0.5	2.6	2.6	0.9	1.9	-1.0
Alzheimer’s Disease (in father)	1.5	1.7	5.0	-2.1	0.7	0.0	-2.2	-2.0	0.6	0.9	0.6	-1.6	0.5	-0.3
Alzheimer’s Disease (including proxy)	0.9	1.3	4.0	-0.7	1.8	0.5	-0.2	-0.0	0.4	2.0	1.9	-0.1	1.4	-0.7
Crohns Disease (2017)	0.5	1.0	2.2	-0.4	1.2	1.2	-0.5	-0.2	-1.2	1.4	1.3	-0.4	1.5	-0.1
Irritable Bowel Disease (IBD)	0.9	2.1	5.4	0.1	2.3	0.8	-0.4	-0.4	-1.6	2.3	2.3	-0.2	1.4	-1.1
Ulcerative Colitis (UC)	0.9	1.7	4.2	0.9	2.0	0.0	0.1	0.2	-1.5	1.8	2.1	0.4	0.4	-1.9
Major Depression (MDD)	0.6	0.7	2.0	-0.4	1.0	-0.4	0.9	1.4	-0.8	0.9	1.1	0.1	0.4	-1.1
Reaction Time	0.8	1.5	4.2	-0.8	-1.3	-2.1	1.2	1.4	-0.7	-1.0	-1.5	-0.2	-1.7	-0.0
Verbal and Numeric Reasoning (VNR)	0.7	1.7	5.9	-0.2	0.9	1.3	-0.8	-1.6	-0.4	1.9	1.8	0.0	2.4	-0.3
Breast Cancer	0.2	0.6	2.2	0.9	-0.9	0.1	0.9	0.3	0.4	-0.7	-0.8	1.5	0.2	0.7
Ovarian Cancer	0.3	0.4	1.5	-0.3	0.0	0.2	-0.2	-0.6	1.1	-0.1	0.2	-0.9	0.5	1.2
Prostate Cancer	0.2	0.3	1.5	0.8	-0.1	0.4	0.5	0.0	0.5	-0.0	-0.1	1.2	0.7	0.6
Age at First Birth	0.8	1.2	2.3	-0.9	1.1	1.5	0.2	-0.4	1.4	1.3	1.1	0.6	1.3	1.1
Bipolar Disorder (2011)	1.4	1.3	2.9	-0.3	-1.3	0.2	1.1	1.0	1.6	-1.4	-1.7	1.2	-0.9	0.9
Body Mass Index (BMI) (2010)	0.3	0.4	1.7	0.6	0.5	-0.4	0.8	0.4	0.4	-0.0	-0.0	1.3	-0.5	-0.6
Coronary Artery Disease (CAD)	0.3	0.3	0.8	-0.9	0.7	0.5	-0.2	-0.2	-0.5	0.8	0.2	0.1	0.8	0.7
Crohns Disease (2012)	0.3	0.5	1.2	-0.8	1.0	0.7	-0.2	0.2	-0.7	1.0	1.1	-0.2	0.7	-0.1
Mean Putamen Volume	0.8	0.9	3.0	0.4	0.8	1.4	0.6	0.5	-0.3	1.2	0.9	1.1	1.7	0.3
Fasting Glucose	0.7	0.8	3.1	-1.8	0.5	-0.8	-0.3	-0.2	-1.3	-0.0	-0.3	-0.9	-0.9	-1.2
HbA1C	1.7	1.8	4.6	1.2	-1.7	-1.0	1.0	0.7	0.7	-2.1	-1.8	0.7	-2.1	0.6
HDL Cholesterol	0.5	0.8	2.3	-0.0	1.5	1.5	-0.0	-0.3	0.4	1.3	1.3	0.3	0.7	0.1
LDL Cholesterol	3.4	5.4	12.8	-0.1	-3.6	-2.7	0.2	0.6	1.0	-3.5	-3.5	-0.5	-3.6	-0.3
Lupus	0.2	0.3	0.9	-0.6	0.8	-0.0	0.4	0.5	0.9	0.6	0.6	-0.4	-0.5	-0.4
Neuroticism (2016)	0.5	0.7	2.2	-0.4	-0.2	0.2	1.2	1.5	1.3	-0.7	-0.2	0.6	-0.9	0.1
Primary Biliary Cirrhosis	0.3	0.4	1.5	-0.2	0.3	0.7	-0.6	-0.0	-1.2	0.2	0.5	-1.0	0.4	-0.5
Rheumatoid Arthritis	0.3	0.3	1.1	0.0	0.2	-0.2	-0.7	-0.6	-0.9	0.6	0.7	-0.2	1.1	-0.4
Schizophrenia (2014)	0.3	0.6	3.6	0.1	-0.8	-0.4	-0.2	0.2	-1.9	-0.5	-0.2	0.0	-0.8	-1.3
Triglycerides	1.2	2.0	4.6	-0.6	-2.0	-1.9	-0.9	-0.4	-0.0	-2.1	-2.1	-1.6	-1.3	0.1
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.0	-0.2	-1.0	-1.4	0.7	1.3	-1.1	-0.3	-0.2	-0.2	-0.1	-1.4
Ulcerative Colitis	0.8	1.2	3.3	1.1	1.8	0.6	0.7	0.7	-0.9	1.4	1.8	0.9	0.5	-0.6
Blood Eosinophil Count	0.9	6.6	24.4	-2.4	-0.3	0.6	-4.9	-4.9	-2.8	-0.0	-0.9	-2.9	1.1	-0.4
Blood Platelet Count	1.0	11.3	33.3	4.9	-5.8	-2.2	1.1	0.1	-2.7	-4.6	-4.4	2.6	-1.5	1.7
Blood Red Count	0.1	0.5	1.6	-0.7	0.7	-0.3	0.4	0.2	0.8	1.2	0.8	1.2	0.3	0.2
Blood White Count	0.8	5.8	14.3	-2.5	-1.8	-3.6	-2.8	-2.2	-3.8	-0.6	-1.0	-2.1	-1.1	-2.6
Heel T-Score	1.3	10.1	39.9	6.3	0.8	2.6	0.6	-1.0	-5.2	1.8	2.5	2.3	4.4	1.1
BMI	0.2	1.2	8.4	0.3	0.9	-0.2	-0.5	-0.0	-1.5	0.6	0.8	-0.6	-0.6	-2.9
Height	1.4	27.9	64.2	-6.4	7.2	0.4	-4.5	-5.5	0.9	7.3	8.0	-5.1	2.8	-3.3
Waist Hip Ratio (WHR)	0.2	1.0	2.8	-0.5	-1.5	-1.7	0.3	1.2	-0.7	-1.3	-1.0	-0.7	-0.6	-0.3
Systolic Blood Pressure	1.9	9.5	41.7	6.3	-1.6	1.3	0.9	0.3	-6.5	-0.2	0.3	1.7	3.8	0.3
Smoking Status	0.3	0.7	1.7	-0.5	-0.9	-0.7	-0.0	0.4	-0.8	-0.8	-1.3	-0.7	-0.9	-1.0
Allergy or Eczema	0.4	1.2	4.0	0.7	1.1	0.7	-0.4	-0.6	-2.0	1.1	1.1	-0.5	1.8	0.4
Cardiovascular Disease	0.5	1.6	10.4	1.7	-0.7	-0.2	-0.2	0.2	-3.2	-0.2	-0.2	-0.2	0.7	-1.7
Hypothyroidism (self reported)	0.2	0.5	1.5	-0.8	0.3	0.3	-0.6	-0.8	1.2	-0.2	-0.6	0.7	-0.8	-0.3
Respiratory disease	1.1	2.5	13.7	2.9	-0.6	-0.3	-1.1	-1.1	-3.7	-0.1	0.4	-0.2	1.6	-0.4
Type 2 Diabetes (T2D) (2018)	0.5	0.9	4.7	-0.0	-0.1	-0.1	-0.9	-0.1	-2.2	0.5	0.6	-1.3	0.6	-1.3
Lung FEV1/FVC ratio	0.3	1.3	4.0	-0.7	-1.9	-0.5	-0.5	-1.1	1.3	-1.4	-2.0	-0.5	-0.5	0.6
Lung FVC	3.3	16.8	30.8	-2.8	4.9	1.6	-3.5	-3.7	-4.3	5.5	5.5	-4.0	4.8	-2.3
Neuroticism	0.6	1.5	5.2	-0.3	-0.3	-1.0	1.9	2.3	0.9	-1.3	-0.8	0.6	-1.7	0.5
Chronotype (morning person)	1.4	3.3	8.2	-1.8	2.9	0.7	-0.7	-0.1	-1.4	2.7	2.6	-1.7	1.3	-1.8
Hair Pigment	0.1	3.2	12.5	-3.5	0.1	-1.9	-2.0	-0.7	0.7	-0.1	0.0	-2.1	-2.2	-2.3
Tanning	0.2	3.0	7.6	-2.8	1.2	-1.3	-2.1	-1.7	-1.2	1.6	0.8	-2.5	0.5	-1.9
Hand grip strength (left)	6.9	18.2	36.8	-5.4	6.0	1.3	-2.8	-2.5	-1.7	6.0	6.1	-4.6	3.4	-3.3
Number of treatments/medications taken	0.5	1.0	4.9	0.6	1.1	-0.4	-0.9	-0.8	-2.2	0.4	0.9	-0.6	-0.0	-1.1
Average weekly spirits intake	0.2	0.3	0.7	0.5	-0.4	0.2	0.0	-0.4	0.7	-0.7	-0.4	0.8	-0.5	0.4
Sensitivity / hurt feelings	1.2	2.0	8.8	-0.9	-0.9	-1.6	0.3	0.6	2.1	-1.6	-0.8	0.2	-3.0	-0.9
Frequency of depressed mood in last 2 weeks	1.0	1.4	3.4	1.1	-1.6	0.2	0.9	1.1	0.8	-1.7	-1.8	0.1	-0.2	1.9
Hearing difficulty/problems: Yes	0.7	1.0	2.6	0.3	1.2	1.6	0.7	0.5	0.4	1.1	1.0	1.3	1.5	0.2
Relative age of first facial hair	0.7	1.5	4.3	-2.1	-1.3	-0.7	-0.8	-0.3	2.1	-1.1	-1.3	-0.3	-1.2	0.6
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	7.1	2.7	-0.8	0.3	1.9	1.3	0.3	-1.5	-1.2	2.4	-0.6	1.2
Ever used hormone-replacement therapy (HRT)	0.9	1.2	7.5	2.7	-0.6	1.4	0.1	-0.1	-0.5	-0.6	-0.0	0.6	1.1	1.0
Ever had hysterectomy (womb removed)	2.1	2.4	5.9	-0.7	-0.2	-1.5	-2.2	-1.4	-2.4	0.3	0.7	-2.4	0.3	-2.0
Systolic blood pressure, automated reading	1.6	4.8	23.9	4.9	-1.6	0.6	0.6	0.5	-4.4	-0.9	-0.4	0.6	2.1	0.4
Eye problems/disorders: Diabetes related eye disease	1.6	1.8	4.0	0.7	-1.7	-0.9	1.6	2.0	0.5	-1.6	-1.8	0.3	-1.6	-0.1
Angina	1.3	1.7	5.1	1.5	-2.3	-0.7	0.4	0.4	-0.3	-2.1	-2.0	0.7	-1.3	0.4
Medication for hormone replacement therapy	1.2	1.3	4.2	1.2	0.7	2.1	0.3	-0.2	-0.0	0.5	0.7	1.2	2.0	1.3
Vitamin and mineral supplements	1.1	1.5	6.8	-2.6	0.5	-0.5	-1.4	-0.6	1.1	0.3	0.5	-2.0	-1.0	-0.9
Supplements: Zinc	0.5	0.6	1.3	1.1	-1.1	0.7	0.5	0.4	0.4	-0.9	-0.8	1.0	0.3	0.8
Medication: Co-codamol	1.4	1.6	8.5	0.8	-0.4	-0.7	1.1	2.0	-2.9	0.1	0.4	-0.3	0.5	-1.4
Medication: Metformin	0.4	0.6	2.2	-0.9	-0.1	-0.4	-0.8	-0.0	-0.6	0.2	0.1	-1.5	-0.1	-1.4
Diabetes (father)	1.1	1.4	3.4	1.3	0.8	1.0	1.8	1.5	0.3	0.9	1.1	1.8	0.8	-0.0
Diabetes (mother)	0.4	0.5	1.5	-1.1	-0.1	-0.8	-0.3	0.2	-0.5	0.1	-0.4	-1.2	-0.8	-1.1
Severe depression (siblings)	0.4	0.5	2.0	-0.1	-0.7	-0.1	0.3	0.2	0.2	-0.9	-0.6	1.0	-0.1	1.4
Pack years adult smoking proportion	1.0	1.6	3.1	1.1	-1.7	0.5	1.4	1.5	0.8	-1.5	-1.8	0.8	-0.5	1.3
Impedance of leg (right)	1.1	5.5	16.7	2.4	-4.1	-1.7	1.3	1.7	-1.9	-3.5	-3.4	1.1	-1.2	1.1
Leg fat-free mass (left)	1.6	8.7	22.4	-3.7	4.7	0.6	-1.6	-1.7	0.1	4.4	4.5	-2.6	1.7	-2.1
Trunk fat percentage	0.6	2.5	10.4	1.4	-1.4	-1.9	-1.1	-0.2	-3.2	-1.1	-0.6	-1.6	-0.8	-1.9
Hand grip strength (right)	4.3	11.7	24.2	-4.6	4.8	0.6	-2.1	-2.1	-1.3	4.9	4.9	-3.5	2.4	-2.9
Townsend deprivation index at recruitment	1.2	1.7	4.9	0.3	-1.7	-0.7	1.4	2.2	0.2	-1.6	-1.5	0.8	-1.6	-0.3
Current tobacco smoking	0.7	1.1	3.0	-1.2	-1.3	-0.9	-0.7	-0.3	-0.2	-1.3	-1.7	-1.1	-1.1	-0.2
Average weekly fortified wine intake	0.1	0.2	0.5	0.1	-0.5	-0.4	-0.4	-0.4	0.3	-0.5	-0.4	-0.2	-0.0	0.7
Maternal smoking around birth	0.2	0.2	0.7	0.6	0.1	0.7	0.6	0.8	0.3	-0.1	0.1	0.4	-0.6	-0.3
Fed-up feelings	0.5	0.8	3.1	-0.9	0.1	-1.8	-0.6	-0.5	-0.4	-0.8	-0.6	-0.7	-1.4	-1.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.8	0.2	-0.2	-0.5	0.5	0.9	-0.8	-0.4	-0.4	-0.5	-0.1	0.2
Relative age voice broke	0.7	1.0	2.6	-1.5	0.2	-1.5	0.3	1.1	0.7	0.2	0.3	-0.1	-1.6	-1.6
Taking other prescription medications	0.8	1.2	4.0	-0.2	0.9	-1.0	-1.3	-0.9	-2.0	0.6	1.1	-1.2	-0.0	-1.2
Age when periods started (menarche)	2.2	5.2	20.7	-1.1	-2.3	-1.1	0.1	0.1	4.5	-2.9	-3.1	0.3	-2.9	1.7
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	4.1	0.4	-0.3	0.2	-2.0	-1.9	-1.7	0.6	0.6	-1.6	1.5	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	5.0	2.2	-1.1	-0.9	0.7	-0.4	-1.2	-0.5	-0.1	1.0	-0.2	-0.5
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.8	0.9	-0.3	0.2	0.3	-0.1	-0.8	-0.3	-0.2	0.7	0.4	0.8
Qualifications: CSEs or equivalent	0.3	0.4	2.6	-0.2	0.3	-0.5	-0.5	-0.0	-1.6	0.1	-0.0	-0.9	0.4	-0.7
Serious illness, injury or assault to yourself	0.7	0.8	2.7	0.1	-0.3	1.6	0.5	0.4	1.6	-0.2	-0.3	0.3	0.8	1.4
High blood pressure	0.5	1.3	5.8	1.1	0.5	1.1	-0.1	0.4	-2.4	0.9	0.9	-0.5	1.7	-1.0
Hayfever, allergic rhinitis or eczema	0.7	1.4	5.0	0.6	1.1	0.3	0.6	0.8	-2.2	1.4	1.6	-0.4	1.7	-0.5
Multivitamins +/- minerals	0.6	0.8	2.2	1.5	0.3	0.5	1.1	1.0	-0.7	0.7	0.4	1.0	1.2	0.5
Stomach or abdominal pain in last month	0.2	0.2	0.6	0.4	0.4	-0.3	0.7	0.6	-0.7	0.1	0.1	0.8	0.1	0.2
Supplements: Glucosamine	0.7	0.9	3.9	1.1	0.2	0.7	-0.6	-0.3	-2.0	0.5	0.9	-0.3	1.6	-0.4
Diverticular disease/diverticulitis (self-reported)	4.2	5.0	13.8	1.1	2.5	2.8	-0.7	-0.9	-2.9	2.6	3.0	-0.2	3.7	0.3
Medication: Atenolol	0.1	0.1	0.4	-0.4	-0.6	-0.0	-0.1	0.1	-0.6	-0.2	-0.1	-0.4	-0.2	-0.6
Medication: Levothyroxine sodium	0.3	0.4	1.2	-0.6	-0.4	0.3	-1.1	-0.9	0.6	-0.7	-0.7	0.5	-0.7	-0.4
Sitting height	2.6	18.2	37.5	-4.8	5.9	1.8	-3.3	-4.9	-0.6	6.1	6.0	-3.4	3.9	-1.7
Chronic bronchitis/emphysema (father)	0.3	0.4	1.3	-0.1	-0.6	0.5	0.0	-0.1	-0.3	-0.5	-0.8	-1.1	0.4	1.1
High blood pressure (mother)	0.3	0.4	1.7	0.2	-0.0	0.9	-0.2	-0.0	-0.9	0.2	0.2	0.1	1.3	1.1
Body mass index (BMI)	0.1	0.4	2.2	0.2	0.5	-0.3	-0.1	0.4	-1.1	0.3	0.5	-0.5	-0.3	-1.5
Impedance of leg (left)	1.0	4.8	15.4	2.2	-3.9	-1.8	0.7	1.3	-2.1	-3.2	-3.1	0.7	-1.3	0.6
Leg predicted mass (left)	1.7	8.8	22.8	-3.7	4.8	0.7	-1.7	-1.7	0.1	4.4	4.5	-2.7	1.8	-2.1
Trunk fat mass	0.4	1.7	5.7	0.2	0.2	-1.3	-1.3	-0.8	-2.4	0.4	0.9	-1.8	-0.3	-2.1
Waist circumference	0.1	0.3	1.1	0.2	-0.1	-0.3	0.4	1.1	-0.4	-0.2	0.2	-0.3	-0.6	-0.8
Number of incorrect matches in round	0.8	1.3	2.6	0.5	-0.7	-1.6	1.0	1.6	-0.5	-1.2	-1.4	0.5	-1.6	-1.1
Past tobacco smoking	0.2	0.3	1.0	0.5	0.5	0.6	-0.1	-0.2	0.1	0.4	0.7	0.1	1.0	0.6
Alcohol usually taken with meals	0.5	0.8	1.8	1.0	0.5	1.2	-0.3	-0.8	0.8	0.8	1.1	0.5	1.4	0.3
Nervous feelings	1.4	2.7	6.1	1.5	-0.9	-2.5	2.4	2.5	-0.1	-1.2	-0.9	1.5	-1.9	-0.2
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	5.9	0.8	0.0	-0.6	2.4	2.3	0.0	-0.5	-0.3	1.4	-0.6	0.5
Hearing difficulty/problems with background noise	2.0	3.2	10.8	2.3	-0.3	1.1	3.3	3.2	0.9	-0.3	-0.2	2.4	0.2	0.2
Hair/balding pattern: Pattern 2	5.1	6.5	13.2	0.3	-2.3	-1.6	2.9	3.1	3.6	-3.0	-2.7	1.4	-3.6	0.9
Had menopause	0.9	1.1	3.9	1.6	-0.4	2.0	-0.4	-0.8	0.9	-0.8	-0.8	0.2	0.6	1.6
Had other major operations	0.5	0.6	2.6	0.5	0.6	1.4	-0.2	-0.1	-0.1	0.4	0.6	-0.0	0.8	1.6
Forced vital capacity (FVC)	3.9	15.1	31.5	-3.3	4.9	0.3	-3.2	-3.6	-3.4	5.3	5.6	-4.0	3.6	-2.9
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	6.3	2.5	-1.1	-0.8	0.9	-0.2	-1.3	-0.5	-0.2	1.6	-0.1	-0.3
Ever unenthusiastic/disinterested for a whole week	2.0	2.5	6.8	1.6	-2.6	-0.7	0.8	0.8	0.6	-2.6	-2.3	0.9	-1.5	1.0
Qualifications: None of the above	0.8	1.7	6.0	1.0	-1.2	-1.7	-0.8	-0.3	-0.9	-1.8	-1.3	-0.8	-2.4	-0.8
Financial difficulties in last 2 years	1.2	1.6	5.2	-1.0	2.3	0.5	0.8	1.1	0.3	1.9	1.7	0.0	0.8	-1.4
Mouth/teeth dental problems	0.3	0.5	1.1	0.6	-0.7	-0.6	-0.3	-0.9	-1.0	-0.1	-0.3	1.0	0.8	0.4
Heart attack	0.7	0.9	2.3	0.5	-1.1	1.0	0.0	-0.3	1.0	-1.5	-1.2	0.8	-0.9	1.2
Allergy	0.6	1.3	5.7	-1.7	-0.8	-0.4	0.0	0.1	2.4	-1.0	-1.4	0.0	-1.1	0.8
Pain all over the body in last month	0.7	0.8	2.5	-0.0	-1.4	0.3	0.3	0.6	0.6	-1.5	-1.6	-0.1	-0.7	0.4
Diabetes (self-reported)	0.4	0.7	1.7	-0.2	0.8	0.9	-0.6	-0.1	-0.6	1.1	1.3	-0.8	0.9	-0.7
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	0.9	-0.1	0.7	0.5	0.6	0.9	0.8	0.2	0.4	0.2	0.3	0.5
Medication: Ramipril	0.5	0.7	3.2	0.6	-0.3	1.3	-0.2	-0.2	0.1	0.2	-0.1	0.3	1.8	1.4
Medication: Simvastatin	0.5	0.7	2.1	0.1	-1.1	-0.9	-0.2	-0.1	0.4	-1.2	-1.2	0.4	-1.4	-0.7
Fluid intelligence score	0.6	1.3	3.8	-0.6	1.2	0.8	-0.5	-1.2	-0.5	2.0	1.5	0.4	1.9	-0.7
Illnesses of siblings	1.0	1.4	4.0	-2.0	1.5	-1.0	-0.4	0.1	0.3	1.6	1.2	-0.7	0.0	-1.8
Neuroticism score	0.8	1.7	4.4	-0.1	-0.8	-1.0	1.9	2.1	1.3	-1.6	-1.1	0.5	-1.6	0.6
Weight	0.8	3.8	8.3	-2.0	2.6	-0.1	-1.7	-1.6	-1.0	2.6	2.9	-2.1	0.8	-2.2
Impedance of arm (right)	0.7	3.1	8.7	2.2	-2.9	-1.9	-0.6	0.0	-3.0	-2.2	-1.7	-0.9	-0.2	0.2
Arm fat percentage (right)	0.3	1.3	5.8	1.3	-1.0	-1.3	-0.4	0.5	-2.4	-0.9	-0.3	-1.0	-0.7	-1.4
Trunk fat-free mass	2.1	12.1	33.1	-4.4	5.8	1.8	-1.4	-2.1	2.0	5.4	5.3	-1.7	2.0	-1.4
Hip circumference	0.1	0.2	0.7	0.7	0.6	0.4	-0.3	-0.2	-0.4	0.5	0.8	-0.1	-0.1	-0.6
Time employed in main current job	0.9	1.0	2.5	-1.3	0.5	-0.6	-1.4	-1.6	-0.9	0.4	0.1	-1.3	-0.2	-1.1
Alcohol intake versus 10 years previously	0.6	0.9	3.2	1.8	-0.6	0.2	1.0	0.6	-0.4	-0.5	-0.5	1.7	-0.0	1.0
Father’s age at death	1.4	1.9	7.7	1.1	0.1	2.1	0.1	-1.1	1.4	0.2	0.3	1.1	1.6	2.8
Worrier / anxious feelings	0.5	0.9	3.0	-0.2	-0.9	-1.7	0.6	0.6	-1.1	-1.3	-1.1	0.3	-1.0	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.5	5.4	2.3	-1.1	0.4	1.3	1.0	-0.6	-1.4	-0.7	1.3	0.3	1.7
Falls in the last year	0.9	1.2	2.4	1.3	-0.5	-0.2	1.1	1.2	1.4	-1.2	-1.0	1.2	-1.5	0.4
Hair/balding pattern: Pattern 3	2.4	3.6	13.9	0.6	1.7	1.0	-0.8	-0.6	-3.7	2.1	2.0	-1.4	2.8	-1.7
Number of live births	1.1	1.6	3.8	-1.6	0.0	-1.5	-1.5	-1.3	-0.7	-0.0	0.4	-1.4	-1.7	-1.9
Forced expiratory volume in 1-second (FEV1)	2.8	9.3	17.6	-3.1	3.6	-0.1	-2.5	-2.8	-2.7	4.2	4.2	-3.3	2.8	-2.4
Pulse rate	0.8	1.4	4.5	0.2	1.3	2.0	-0.1	-0.6	-0.1	1.1	0.9	0.4	2.1	1.6
Happiness	0.3	0.3	0.9	0.0	-0.9	-0.4	0.3	-0.4	0.3	-0.9	-0.7	0.1	-0.7	0.6
Noisy workplace	0.9	1.1	3.4	0.3	0.2	-1.5	0.9	1.5	-1.1	0.4	0.6	0.9	-0.9	-1.8
Qualifications: A levels/AS levels or equivalent	0.2	0.5	2.1	-0.6	0.4	1.2	-0.1	-0.5	0.7	0.7	0.3	0.3	1.4	0.7
Serious illness, injury or assault of a close relative in last 2 years	1.1	1.2	2.5	0.8	-1.4	-1.2	1.5	1.1	0.2	-1.1	-1.6	1.4	-0.7	0.4
Mouth/teeth dental problems: Dentures	0.6	1.0	4.2	-0.6	0.9	0.1	0.0	0.7	0.2	0.5	0.9	-1.4	-1.3	-2.0
Asthma	1.2	2.4	8.2	2.1	0.6	0.3	-2.0	-1.8	-2.9	0.9	1.4	-0.3	1.5	-0.8
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	2.0	-0.2	1.3	0.4	0.6	0.5	-1.0	1.2	1.4	0.9	1.2	-0.0
Medication: Cholesterol lowering	0.9	1.4	3.8	1.4	-1.1	-0.6	1.2	1.0	0.9	-1.4	-1.1	1.4	-1.9	-0.4
Depression (self-reported)	1.3	1.5	4.6	0.2	-0.3	1.0	2.0	1.5	1.2	-0.6	-0.5	1.6	0.3	2.1
Medication: Lansoprazole	0.8	0.9	2.6	0.5	-1.0	0.1	-1.5	-1.4	-0.9	-0.9	-0.2	-1.6	-0.1	-0.1
Prospective memory result	0.9	1.1	3.8	0.7	-0.3	-1.2	1.4	2.0	0.5	-0.8	-0.5	1.0	-1.5	0.1
Lung cancer (father)	0.6	0.6	1.8	0.9	-1.1	-1.1	0.2	0.4	-0.6	-0.8	-0.5	0.6	-1.3	-0.6
Illnesses of mother	1.0	1.2	4.6	-0.2	-1.0	-1.7	-0.4	-0.4	0.6	-1.3	-1.3	-0.6	-2.1	-0.7
Forced expiratory volume in 1-second (FEV1), Best measure	3.5	11.3	23.6	-3.3	4.3	0.4	-2.5	-3.0	-2.4	4.9	4.7	-3.6	3.0	-2.5
Pulse wave Arterial Stiffness index	0.8	0.9	2.8	-0.9	-1.0	0.6	-0.3	-0.3	0.0	-1.2	-1.6	-0.8	0.2	1.7
Impedance of arm (left)	0.9	4.1	11.5	2.0	-3.4	-2.3	-1.0	-0.4	-2.7	-2.9	-2.4	-1.1	-0.9	0.3
Arm fat mass (right)	0.3	1.2	4.3	-0.2	0.7	-1.0	-0.8	-0.2	-1.8	0.7	1.1	-1.5	-0.2	-2.1
Trunk predicted mass	2.1	12.0	33.4	-4.3	5.8	1.9	-1.3	-2.0	2.0	5.4	5.4	-1.7	2.0	-1.4
Standing height	1.5	14.6	31.4	-4.7	5.1	0.5	-3.5	-4.4	0.1	5.2	5.6	-3.7	2.6	-1.7
Length of working week for main job	0.3	0.3	1.1	0.1	-0.5	-0.2	0.5	0.7	0.3	-0.3	-0.6	-0.3	-1.0	-0.8
Exposure to tobacco smoke at home	1.8	2.0	5.9	-0.6	-1.7	-1.6	-0.6	-0.4	0.5	-1.9	-2.3	-0.6	-2.4	-0.8
Breastfed as a baby	0.6	0.8	4.1	-0.3	0.4	0.5	-1.4	-2.0	0.3	0.7	0.7	-0.2	1.0	0.2
Tense / ‘highly strung’	0.3	0.5	2.3	-0.2	-0.3	-0.6	1.2	1.5	-0.6	-0.6	-0.2	-0.6	-0.2	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.4	0.5	-0.1	0.3	-0.3	0.3	0.0	0.2	0.2	-0.1	0.6
Hair/balding pattern: Pattern 4	0.6	1.4	6.5	0.7	1.5	0.6	-1.0	-1.1	-2.5	0.7	1.5	-0.7	0.5	-0.4
Birth weight of first child	0.8	1.5	3.7	-1.5	1.7	-0.2	1.5	1.8	0.3	1.2	1.9	-0.5	0.1	-0.8
Peak expiratory flow (PEF)	0.3	0.8	2.5	-1.2	1.0	-0.1	-0.6	-1.6	0.2	1.2	1.0	0.2	0.3	-0.3
Pulse wave reflection index	0.3	0.4	1.3	-1.1	0.2	-0.0	0.0	0.7	-1.1	0.5	0.0	-0.9	0.2	-0.5
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.8	-0.1	-0.2	-0.9	0.6	0.7	0.3	0.0	-0.0	0.2	-0.5	-0.3
Loud music exposure frequency	1.3	1.4	3.0	0.7	-0.6	0.5	1.7	1.6	0.9	-1.3	-1.2	1.7	-0.5	1.2
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	2.2	-1.3	0.0	0.8	-0.2	-0.3	0.8	0.2	-0.2	-0.4	1.1	1.5
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	4.0	0.6	-0.6	-0.4	0.4	0.1	2.0	-1.0	-1.2	0.8	-1.8	0.8
Blood clot in the leg (DVT)	1.2	1.5	9.9	-0.2	-0.8	-1.4	-0.1	-0.3	0.8	-1.4	-1.0	-0.2	-3.1	-0.9
Medication: Paracetamol	0.6	1.0	5.2	0.5	0.7	-1.6	-0.1	0.2	-2.3	0.2	0.9	0.2	-0.4	-1.3
Headache pain in last month	0.6	1.0	1.9	1.1	1.2	0.7	1.4	1.1	-0.2	0.7	1.1	1.1	0.9	1.0
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	3.2	-0.3	0.3	0.6	-0.7	-1.1	0.1	0.7	0.6	-0.4	1.8	1.4
Glaucoma (self-reported)	0.9	1.1	3.5	1.1	-0.1	0.7	1.9	1.6	0.8	-0.4	-0.5	1.6	-0.6	0.3
Gout (self-reported)	1.0	1.4	2.6	1.6	-0.9	-1.4	1.2	1.6	-1.2	-1.1	-0.8	0.7	-1.1	-1.1
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.2	-0.5	0.0	0.4	-0.6	-0.9	0.7	-0.2	-0.5	1.1	-0.7	-0.3
Medication: Amlodipine	0.7	1.0	5.2	0.2	0.0	-1.1	-0.3	0.2	-1.8	0.2	0.2	-0.6	-0.6	-2.3
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.6	0.3	-0.3	-0.9	-1.6	-1.1	-1.3	-0.4	-0.3	-1.2	-0.3	-0.5
Birth weight	1.4	3.0	7.7	1.8	-1.4	0.2	2.4	1.8	1.9	-1.0	-1.4	2.1	-0.2	2.8
Chronic bronchitis/emphysema (mother)	0.1	0.2	0.9	-0.1	0.1	0.4	0.3	0.9	-0.7	0.2	-0.1	-0.2	0.3	-0.3
High blood pressure (siblings)	0.8	1.2	3.6	1.9	-0.7	1.0	-0.5	-1.1	-1.5	-0.4	0.0	-0.2	1.4	1.4
Forced vital capacity (FVC), Best measure	4.4	16.2	34.3	-3.6	5.3	0.6	-2.9	-3.3	-3.1	5.9	5.8	-4.2	3.6	-2.9
Body fat percentage	0.5	1.9	8.5	1.6	-1.4	-1.5	-0.4	0.6	-2.9	-1.1	-0.6	-1.0	-0.7	-1.5
Leg fat percentage (right)	0.5	1.7	4.5	1.7	-1.5	-0.8	0.9	1.8	-2.1	-1.4	-1.1	0.2	-0.9	-0.7
Arm fat-free mass (right)	1.5	7.9	22.0	-3.8	4.7	1.1	-1.2	-1.7	1.4	4.3	4.1	-1.6	1.2	-1.9
Exposure to tobacco smoke outside home	0.3	0.4	1.1	-0.6	-1.1	-0.3	-0.6	0.1	-0.2	-0.9	-0.9	-0.8	-0.5	-0.3
Comparative body size at age 10	0.2	0.4	1.6	0.8	0.0	0.2	0.1	0.4	-1.0	0.1	0.3	0.4	1.2	0.9
Number of full brothers	4.2	5.2	15.6	1.4	-1.8	1.5	2.9	2.4	4.0	-2.1	-2.1	1.9	-1.1	2.6
Worry too long after embarrassment	0.8	1.3	6.9	-0.6	-0.7	-0.3	0.9	0.9	2.6	-1.2	-0.9	0.2	-1.2	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.6	2.2	1.5	-0.7	-0.0	1.2	0.7	-0.2	-0.9	-0.4	0.2	-0.2	0.9
Wheeze or whistling in the chest in last year	0.8	1.5	10.6	0.8	0.4	-0.5	-0.8	-0.7	-3.3	0.6	0.8	-0.6	0.4	-1.4
Number of children fathered	0.8	0.9	5.3	-1.5	0.3	0.5	-0.8	-0.6	2.3	-0.2	-0.2	-0.1	-0.8	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	2.8	0.3	-0.3	-1.5	0.8	0.5	0.6	-0.7	-0.9	1.2	-1.7	-0.8
Age at first live birth	2.0	3.6	9.2	0.4	2.0	2.6	0.4	-0.9	1.1	2.2	2.4	1.2	3.0	2.4
Pulse wave peak to peak time	0.9	1.1	4.1	0.7	1.3	-0.5	0.2	0.1	-0.0	1.4	2.0	0.7	0.0	-1.8
Health satisfaction	0.3	0.4	1.7	-0.5	0.8	0.4	-0.0	0.1	0.7	0.1	0.5	0.2	-1.2	-1.3
Shortness of breath walking on level ground	1.2	1.4	4.3	1.6	-1.0	-0.3	0.6	0.8	0.9	-1.8	-1.1	1.1	-2.1	0.3
Qualifications: College or University degree	0.9	2.8	11.3	-1.1	2.0	1.5	0.7	0.1	-0.9	2.5	2.0	0.9	3.4	0.3
Eye problems/disorders: None of the above	4.0	4.6	8.1	-2.8	2.0	-0.9	-2.6	-2.1	-1.3	2.5	1.9	-2.8	1.1	-2.5
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.7	0.2	-0.9	-0.9	-0.2	0.3	-1.6	-0.5	-0.6	-1.3	-0.1	-0.1
Emphysema/chronic bronchitis	0.6	0.6	1.7	1.3	-1.2	-0.2	0.4	0.1	-0.4	-1.1	-1.1	0.4	-0.3	0.8
Medication for pain relief, constipation, heartburn	1.0	1.7	10.0	-0.7	-0.9	1.2	0.8	0.7	3.2	-0.9	-1.6	-0.3	-0.6	1.3
Neck or shoulder pain in last month	0.6	0.8	3.2	1.8	0.5	1.4	0.2	0.2	-0.9	0.6	0.8	0.5	1.2	0.5
Medication: Blood pressure	0.4	0.7	2.9	0.2	1.0	0.1	0.9	1.1	-0.6	0.7	0.7	0.4	-0.4	-1.7
Angina (self-reported)	0.9	1.2	3.3	1.4	-1.8	-0.5	0.3	0.3	-0.3	-1.7	-1.6	0.9	-1.0	0.4
Migraine (self-reported)	1.1	1.4	3.6	0.0	0.8	-0.8	-1.3	-1.1	-1.9	1.2	1.3	-1.2	0.3	-1.5
Medication: Ibuprofen	0.4	0.5	1.0	-0.0	1.0	-0.0	-0.1	-0.3	-0.9	0.9	1.0	0.6	0.8	-0.3
Medication: Allopurinol	0.4	0.6	1.6	0.6	-1.2	-0.9	-0.1	0.5	-1.0	-1.0	-0.8	-0.7	-0.4	-0.3
Medication: Omeprazole	0.6	0.7	2.2	1.5	0.8	0.9	-0.1	-0.1	-0.8	0.8	0.9	1.2	0.9	-0.4
Medication: Seretide 50 evohaler	1.8	2.1	4.0	0.1	1.6	1.3	-1.2	-1.0	-1.9	1.8	2.0	-1.0	1.9	-0.8
Mean time to correctly identify matches	1.3	2.4	8.7	-0.2	-2.0	-1.8	0.5	0.6	0.9	-2.0	-2.3	-0.4	-3.0	0.2
Heart disease (mother)	2.0	2.4	6.1	2.3	-1.0	2.5	1.7	1.4	1.0	-1.0	-0.4	1.7	0.7	2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	1.8	-0.1	1.4	0.5	1.0	1.2	0.3	1.0	1.1	1.3	-0.1	-1.2
Whole body fat mass	0.4	1.5	5.4	0.1	0.5	-1.2	-1.0	-0.4	-2.3	0.6	1.1	-1.5	-0.1	-2.2
Leg fat mass (right)	0.2	0.8	3.7	-0.0	0.5	-0.8	-0.1	0.4	-1.9	0.5	0.8	-1.0	-0.2	-1.6
Arm predicted mass (right)	1.4	7.4	21.7	-3.7	4.7	1.0	-1.0	-1.4	1.6	4.2	4.0	-1.4	1.0	-1.8
Pulse rate, automated reading	0.5	1.6	4.0	0.7	1.4	0.8	2.0	1.9	-1.1	0.9	1.1	1.3	1.3	0.7
Alcohol intake frequency.	0.1	0.3	0.6	0.2	0.7	0.1	-0.6	-0.6	-0.7	0.7	0.8	-0.7	0.3	-0.1
Comparative height size at age 10	1.6	8.6	18.9	-2.7	4.2	-0.4	-2.4	-2.6	-2.2	4.0	4.3	-3.2	1.4	-2.5
Number of full sisters	0.9	1.1	2.7	1.0	0.9	-0.7	0.7	0.3	-1.5	1.0	0.9	1.6	-0.2	-1.5
Suffer from ‘nerves’	0.9	1.4	7.2	-0.0	0.2	-1.4	2.2	2.7	-0.4	0.2	-0.1	0.7	-0.6	-0.6
Overall health rating	0.3	0.7	4.8	0.9	-0.1	-0.3	0.1	0.5	-2.2	-0.2	0.3	-0.8	0.1	-0.7
Chest pain or discomfort	0.8	1.1	8.2	0.5	-0.4	-0.7	-0.6	-0.1	-2.9	0.1	-0.3	-0.9	0.5	-1.3
Had major operations	1.3	1.5	5.2	1.1	-0.5	0.8	1.7	1.1	1.2	-0.9	-0.6	2.3	-0.3	1.6
Age at last live birth	1.5	2.2	5.9	0.4	1.7	1.5	0.8	-0.1	0.0	2.1	2.3	1.2	2.4	1.2
Family relationship satisfaction	0.9	1.1	5.9	-0.7	-1.1	-2.4	-0.3	-0.4	-0.3	-0.7	-0.4	-0.7	-1.4	-0.9
Leg pain on walking	0.9	1.1	2.9	-0.1	1.6	0.5	-1.0	-0.7	-0.9	1.4	1.7	-0.8	0.9	-0.6
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	0.6	0.4	-0.5	-0.6	0.6	0.8	-0.5	-0.4	-0.6	-0.0	-0.7	-0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.6	-0.4	-0.3	-0.5	-0.4	-0.7	-0.1	-0.4	-0.6	-0.8	-0.7	-0.4
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.7	0.2	0.2	0.3	-0.8	-0.7	-1.3	0.2	0.4	-0.5	1.0	-0.4
Medication: Aspirin	0.5	0.7	2.1	-0.1	0.1	-0.6	-1.3	-1.4	-1.2	0.6	0.7	0.2	-0.2	-1.1
Supplements: Vitamin C	1.4	1.7	3.8	1.8	-1.7	0.1	0.8	0.2	0.3	-1.7	-1.9	2.0	-0.6	0.7
Knee pain experienced in last month	0.5	0.8	2.0	1.3	0.6	-0.4	0.9	1.4	-1.3	0.3	0.6	0.0	0.1	-1.1
Hypertension (Self-reported)	0.5	1.3	5.5	1.2	0.5	1.4	-0.2	0.2	-2.4	0.9	0.9	-0.2	1.8	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.7	0.8	3.4	1.8	-0.1	1.7	0.6	0.3	-0.8	-0.5	0.1	0.4	0.7	0.7
Illnesses of father: Heart disease	0.3	0.4	1.7	0.9	0.3	0.4	0.6	0.2	-0.9	0.3	0.0	1.3	0.8	0.2
Illnesses of siblings: Diabetes	0.2	0.2	0.7	0.5	-0.8	-0.2	0.3	0.3	0.5	-0.5	-0.4	-0.3	-0.4	0.2
Smoking status: Previous	0.1	0.1	0.6	0.1	0.2	-0.1	0.3	0.3	-0.8	0.2	-0.2	-0.0	-0.1	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.2	3.1	-1.0	1.8	0.9	1.1	0.5	1.0	1.6	1.7	0.4	0.6	0.1
Whole body fat-free mass	2.0	11.6	31.6	-4.3	5.6	1.4	-1.6	-2.0	1.2	5.2	5.2	-2.2	2.0	-1.8
Leg fat-free mass (right)	1.9	10.1	25.5	-3.9	5.0	0.8	-2.0	-2.1	0.3	4.6	4.8	-2.8	1.8	-2.2
Arm fat percentage (left)	0.4	1.4	4.9	1.3	-1.1	-1.4	-0.3	0.6	-2.2	-1.1	-0.6	-0.9	-0.9	-1.4
Average weekly red wine intake	0.8	1.2	3.6	-1.9	1.3	-0.6	-0.6	-0.3	-0.0	1.5	1.5	-1.2	0.3	-1.2
Handedness (chirality/laterality): Left-handed	0.7	0.8	2.9	1.7	0.2	0.7	0.1	-0.4	-1.3	0.2	0.5	1.4	0.9	0.7
Mood swings	0.7	1.3	3.9	-0.0	-0.9	-1.4	1.4	1.5	0.2	-1.5	-1.1	0.1	-2.0	-0.1
Loneliness, isolation	0.5	0.7	3.2	0.0	1.0	1.8	0.2	0.3	1.1	0.6	1.0	-0.7	0.3	0.4
Long-standing illness, disability or infirmity	0.8	1.1	5.6	0.8	1.1	0.2	-0.8	-0.9	-2.4	0.8	0.9	-0.9	1.1	-0.5
Ever had bowel cancer screening	0.3	0.3	1.5	0.9	0.3	-0.1	-0.5	-1.2	0.6	-0.3	0.2	0.3	-0.3	0.5
Diabetes diagnosed by doctor	0.2	0.4	0.7	0.3	0.3	0.8	0.1	0.8	-0.5	0.7	0.9	-0.3	0.6	-0.8
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	3.1	-0.2	1.3	1.8	0.8	0.3	-0.0	1.4	1.6	1.0	1.7	1.5
Friendships satisfaction	0.9	1.2	3.1	1.3	-1.4	-1.0	1.4	0.4	-0.3	-1.0	-0.9	1.8	-0.7	0.1
Qualifications: nursing, teaching	2.2	3.5	11.8	-1.2	1.5	2.6	-1.6	-2.1	-0.0	2.1	1.6	-0.6	3.4	1.1
Commuting to job workplace: Walk	0.9	1.0	3.8	0.4	-0.5	1.3	0.6	0.5	1.0	-1.0	-1.1	1.0	0.4	1.9
Eye problems/disorders: Cataract	3.7	4.3	9.9	2.7	-2.2	0.6	2.0	1.1	1.4	-2.4	-2.2	3.1	-1.6	2.0
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	4.4	-0.4	1.1	2.1	0.8	1.2	0.4	0.9	0.9	-0.1	1.6	1.2
Medication for cholesterol	0.5	0.7	2.7	-0.6	0.1	-0.8	1.0	1.1	1.3	-0.1	-0.4	0.1	-1.6	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.2	0.7	0.1	0.6	0.9	1.1	-0.4	-0.1	0.3	0.0	0.2	0.1
Back pain experienced in last month	0.2	0.3	1.1	1.0	0.1	-0.1	0.3	-0.2	-0.2	-0.6	-0.0	0.7	-1.1	0.5
Mineral and other dietary supplements	0.7	1.0	4.5	-2.1	-0.1	-0.8	-0.2	-0.2	2.0	-0.2	-0.6	-0.7	-0.9	0.3
Breast cancer (self-reported)	0.4	0.4	1.3	-0.3	-0.3	-0.1	-0.9	-1.1	0.6	-0.5	-0.8	-0.5	-0.8	0.5
Asthma (self-reported)	1.4	2.7	9.4	2.1	0.4	0.4	-2.3	-2.1	-3.1	0.8	1.4	-0.5	1.8	-0.6
Osteoporosis (self-reported)	1.2	1.5	3.3	0.7	-0.7	-0.7	1.8	1.8	1.1	-1.3	-1.1	1.3	-1.4	0.7
Osteoarthritis (self-reported)	1.3	1.7	8.1	0.4	-0.2	-1.4	-1.2	-0.2	-2.9	-0.1	0.3	-1.0	-0.9	-2.2
Medication: Aspirin	0.6	0.8	2.0	-0.2	0.2	-1.0	-1.2	-1.2	-1.4	0.7	0.7	0.1	-0.3	-1.4
Medication: Gliclazide	0.6	0.7	2.0	-0.4	1.0	0.7	1.1	1.4	0.4	0.9	1.2	-0.3	-0.0	-0.9
Illnesses of father: None of the above (group 1)	0.4	0.5	1.4	-0.6	-0.5	-0.4	0.0	0.6	1.0	-0.8	-0.5	-0.7	-1.2	-0.0
Smoking status: Current	0.3	0.6	1.7	-1.3	-0.6	-0.5	-0.7	-0.3	-0.5	-0.6	-1.0	-1.1	-0.5	-0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	4.1	10.5	-1.0	3.0	1.4	-1.4	-1.7	-0.7	3.1	3.2	-1.4	2.1	-1.2
Whole body water mass	2.0	11.3	30.2	-4.3	5.5	1.3	-1.6	-2.0	1.2	5.1	5.1	-2.3	1.9	-1.9
Leg predicted mass (right)	1.9	10.1	25.1	-4.0	5.0	0.8	-2.1	-2.2	0.3	4.6	4.7	-2.9	1.8	-2.2
Arm fat mass (left)	0.3	1.1	3.7	-0.2	0.7	-0.8	-0.8	-0.3	-1.5	0.7	1.1	-1.5	-0.1	-1.9
Number of self-reported non-cancer illnesses	0.4	0.8	2.0	1.4	-0.6	-0.8	-0.7	-0.8	-1.4	-1.1	-0.9	0.2	-0.6	0.1
Average weekly champagne plus white wine intake	0.3	0.4	1.2	0.3	0.8	0.8	-0.4	-0.5	0.2	0.7	1.1	0.0	0.8	-0.1
Miserableness	1.9	3.2	7.7	1.5	-1.6	-0.7	2.6	2.8	1.6	-2.0	-1.9	1.3	-1.7	1.1
Guilty feelings	1.8	2.8	8.8	1.0	-1.5	1.2	1.7	1.6	3.0	-1.9	-1.5	0.8	-0.6	2.1
Wears glasses or contact lenses	0.3	0.3	0.7	0.2	-0.5	0.6	0.7	0.3	0.7	-0.4	-0.2	0.6	0.3	0.9
Ever taken oral contraceptive pill	1.8	2.0	5.2	1.3	-0.3	1.7	2.3	2.2	0.7	-0.1	-0.2	1.8	1.3	1.5
Hearing aid user	0.2	0.3	1.3	0.2	-0.2	1.1	0.4	0.4	0.6	-0.2	-0.3	0.7	-0.1	0.4
Mother’s age at death	0.3	0.4	2.1	0.1	-0.2	-0.0	-0.3	-0.7	0.9	-0.2	-0.2	0.5	0.6	1.5
Financial situation satisfaction	1.2	1.4	4.4	-0.8	0.3	-0.3	-1.1	-0.7	-2.1	0.7	0.9	-1.7	0.5	-2.0
Tinnitus: Yes, now most or all of the time	6.1	7.1	18.1	4.0	-0.8	1.4	4.2	3.7	2.2	-1.4	-0.7	3.8	-0.5	2.5
Commuting to job workplace: Public transport	0.4	0.5	2.5	-1.6	0.1	1.0	-0.0	0.6	1.0	0.4	0.3	0.0	0.4	0.0
Eye problems/disorders: Glaucoma	1.4	1.7	2.8	1.5	-0.6	1.3	1.7	1.5	1.3	-1.2	-1.2	1.6	-0.4	1.4
Medication: Blood pressure	0.5	1.0	3.9	1.3	-0.4	0.9	-1.0	-0.9	-2.0	0.3	0.2	-0.6	1.7	-0.2
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.9	1.7	-0.1	-0.4	0.6	0.8	-1.0	-0.3	0.4	0.1	-0.8	-1.2
Supplements: Fish oil (including cod liver oil)	0.9	1.1	6.4	1.7	0.3	0.0	-0.1	-0.3	-2.5	0.5	0.9	-0.1	0.7	-1.4
High cholesterol (Self-reported)	0.5	0.9	1.8	0.7	-1.4	-0.9	0.4	0.7	-0.7	-1.2	-1.3	0.6	-1.2	-0.7
Medication: Bendroflumethiazide	0.2	0.3	1.3	-0.2	0.0	0.9	-0.6	-0.4	0.1	0.3	0.6	-0.2	1.1	0.3
Medication: Paracetamol	0.9	1.4	5.5	0.8	1.4	-0.6	-0.5	-0.2	-2.3	1.0	1.6	0.3	0.0	-1.8
Medication: Lisinopril	0.2	0.2	0.7	-0.4	0.8	0.6	-0.3	0.0	-0.5	0.6	0.4	0.0	0.8	0.2
Medication: Atorvastatin	0.8	0.9	3.0	-1.7	0.6	-0.6	-1.0	-1.2	-0.2	0.7	0.7	-1.2	-0.5	-1.4
Illnesses of father: High blood pressure	0.4	0.4	2.0	0.7	0.3	1.0	0.3	-0.1	-0.8	0.4	0.2	0.4	1.4	0.1
Alcohol drinker status: Never	1.4	1.7	3.3	-0.6	1.0	-0.7	-1.5	-1.5	-1.8	1.2	1.3	-1.8	1.2	-0.9
Ever smoked	0.2	0.3	1.1	-1.1	-0.4	-0.6	0.5	0.5	0.2	-0.4	-0.6	0.1	-0.8	-0.2
Basal metabolic rate	1.6	8.9	23.9	-3.8	4.9	1.0	-1.4	-1.7	0.7	4.6	4.7	-2.2	1.7	-1.9
Leg fat percentage (left)	0.4	1.6	5.1	1.5	-1.2	-1.0	0.6	1.6	-2.3	-1.1	-0.8	-0.0	-1.0	-1.3
Arm fat-free mass (left)	1.6	8.1	23.4	-3.5	4.8	1.0	-1.0	-1.3	1.0	4.5	4.5	-1.6	1.4	-2.0
Number of operations (self-reported)	1.4	2.0	6.5	1.2	-0.5	1.6	0.9	0.8	2.5	-1.0	-0.7	1.5	-0.3	2.5
Average weekly beer plus cider intake	0.7	0.9	6.6	-0.4	0.0	-0.1	-0.1	0.9	-2.6	0.5	0.4	-0.9	0.8	-1.0
Irritability	0.3	0.5	2.8	-0.2	-0.2	0.3	0.2	0.1	1.0	-0.6	-0.6	0.8	0.2	1.7
Risk taking	0.8	1.2	2.9	-1.5	1.5	1.7	-0.3	-0.3	1.4	1.4	0.8	-0.5	0.9	0.6
Ever had prostate specific antigen (PSA) test	2.0	2.3	9.0	-1.4	1.0	0.6	-2.6	-3.0	0.0	0.9	1.4	-1.0	1.3	0.4
Fractured/broken bones in last 5 years	0.5	0.6	2.2	-1.5	0.3	-1.2	-1.2	-0.6	0.5	0.1	0.3	-0.8	-0.6	-0.3
Age started oral contraceptive pill	1.1	1.3	4.5	0.9	-1.1	0.5	-0.0	-0.6	2.1	-1.2	-1.1	1.1	-0.1	2.0
Diastolic blood pressure, automated reading	1.5	4.5	12.3	2.4	2.2	1.8	0.2	0.1	-3.5	2.4	2.5	-0.0	3.5	-0.3
Ever depressed for a whole week	1.9	2.4	8.1	1.4	-1.1	-1.1	2.6	2.9	0.4	-1.0	-1.0	1.7	-1.4	-0.3
Unable to work because of sickness or disability	2.1	2.7	6.5	-1.2	1.8	0.6	0.4	1.2	-2.5	2.1	1.8	-0.9	2.0	-1.7
Commuting to job workplace: Cycle	1.2	1.4	3.8	-1.0	2.0	0.8	-0.7	-1.0	0.4	1.9	1.7	-0.0	1.4	-0.2
Myopia	0.5	0.8	2.8	-1.7	-0.1	-1.3	-0.5	-0.3	-0.7	0.1	0.2	-1.5	-0.2	-0.8
Vascular/heart problems diagnosed by doctor	0.3	0.9	3.9	-1.8	0.6	-0.6	-0.4	-0.6	2.0	0.3	0.3	-0.1	-0.8	0.5
Cholesterol lowering medication	0.7	1.0	2.5	0.4	-1.6	-1.2	-1.1	-0.8	-0.9	-1.3	-1.1	-0.3	-1.0	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.5	1.2	0.9	0.9	-0.9	-1.1	-0.8	1.0	1.2	0.4	0.9	-0.3
Pain experienced in last month	0.2	0.3	0.9	-0.8	-0.8	0.1	-0.7	-0.5	-0.4	-0.0	-0.5	-0.6	1.0	-0.1
Supplements: Calcium	0.7	0.8	3.8	0.1	0.5	0.5	-1.6	-1.9	-0.3	0.4	0.5	-0.3	1.1	0.3
Basal cell carcinoma (self-reported)	0.2	0.2	0.7	0.4	0.1	0.8	0.3	0.6	0.6	0.2	0.5	0.1	0.3	0.8
Heart attack/myocardial infarction (self-reported)	0.5	0.7	1.6	0.2	-0.9	1.0	-0.0	-0.4	1.0	-1.2	-1.0	0.5	-0.7	1.0
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	10.0	-0.4	-0.5	-1.5	-0.4	-0.7	0.6	-1.2	-0.8	-0.5	-3.2	-1.2
Heart disease (siblings)	3.2	3.9	8.8	1.3	-2.6	-0.4	1.2	1.0	1.7	-2.9	-3.0	1.7	-2.7	1.2
Alcohol drinker status: Previous	0.8	0.9	3.4	0.5	0.1	-1.5	0.7	1.0	-1.9	0.3	0.0	0.2	-0.4	-1.4
Pack years of smoking	1.1	1.5	3.6	0.9	-1.8	0.5	1.1	1.3	1.0	-1.7	-1.9	0.6	-0.8	1.2
Impedance of whole body	1.1	5.7	18.1	2.9	-4.3	-2.3	-0.1	0.4	-2.8	-3.5	-3.2	0.0	-1.0	0.7
Leg fat mass (left)	0.3	1.1	3.8	-0.2	0.7	-0.8	-0.3	0.3	-1.9	0.7	1.0	-1.2	-0.2	-1.9
Arm predicted mass (left)	1.8	9.3	25.6	-3.6	5.1	1.4	-1.3	-1.6	0.9	4.8	4.8	-1.9	1.9	-1.9