TWAS hub - HIGD1B

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.046	0.0240	0.0040	0.049	0.015	0.034	0.019	0.036	1.4e-06	0.0054	5.3e-05	0.0021	3.2e-05
2	GTEx	Lung	0.093	0.0402	0.0018	0.043	NA	0.043	NA	0.045	3.0e-04	NA	3.1e-04	NA	2.2e-04

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Hand grip strength (left)	8.0	21.2	36.8	2.4	-6.1
Hand grip strength (right)	5.7	15.5	24.8	2.5	-5.0
Qualifications: None of the above	5.4	11.6	20.8	4.6	1.6
Intelligence (Savage-Jansen 2018)	5.2	16.0	24.3	-4.9	-2.8
Forced vital capacity (FVC), Best measure	5.1	18.6	35.8	1.2	-6.0
Hair/balding pattern: Pattern 2	4.6	5.9	9.2	1.6	3.0
Age at first live birth	4.4	7.8	10.0	-3.2	-2.4
Forced vital capacity (FVC)	4.3	16.4	29.8	1.8	-5.5
LDL Cholesterol	4.2	6.7	11.6	1.4	3.4
Qualifications: College or University degree	4.2	13.3	19.6	-4.4	-2.7
Qualifications: nursing, teaching	4.0	6.3	9.2	-3.0	-1.8
Ever taken oral contraceptive pill	4.0	4.4	8.8	-3.0	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	3.9	12.5	24.9	0.3	-5.0
Ever had stillbirth, spontaneous miscarriage or termination	3.8	4.0	5.7	-2.4	-1.5
Heart disease (siblings)	3.8	4.6	8.8	0.6	3.0
Eye problems/disorders: Cataract	3.7	4.3	6.9	-1.3	2.6
Alzheimer’s Disease (in mother)	3.6	4.2	6.1	-1.5	-2.5
Eye problems/disorders: None of the above	3.5	4.0	6.2	1.3	-2.5
Number of full brothers	3.4	4.2	5.0	-1.9	2.2
Fed-up feelings	3.3	6.0	11.0	3.3	1.0
Diverticular disease/diverticulitis (self-reported)	3.3	3.9	7.1	-0.8	-2.7
Whole body fat-free mass	3.3	19.0	29.8	2.9	-5.5
Whole body water mass	3.3	18.6	28.6	2.9	-5.3
Sitting height	3.2	22.6	41.7	1.9	-6.5
Trunk fat-free mass	3.2	18.3	31.2	2.3	-5.6
Trunk predicted mass	3.2	18.5	31.6	2.3	-5.6
Leg fat-free mass (right)	3.2	17.0	23.7	3.2	-4.9
Leg predicted mass (right)	3.2	16.8	23.3	3.2	-4.8
Comparative height size at age 10	3.1	17.2	18.3	4.0	-4.3
Systolic Blood Pressure	3.0	15.0	29.9	-5.5	0.2
Leg fat-free mass (left)	3.0	15.9	21.4	3.2	-4.6
Leg predicted mass (left)	3.0	16.1	21.5	3.3	-4.6
Number of incorrect matches in round	3.0	5.0	7.6	2.8	1.5
Arm predicted mass (left)	3.0	15.3	25.4	2.3	-5.0
Depressed Affect (Nagel 2018)	2.9	6.1	11.0	3.3	1.1
Lung FVC	2.9	14.7	29.5	0.0	-5.4
Ever unenthusiastic/disinterested for a whole week	2.9	3.6	7.1	0.2	2.7
Basal metabolic rate	2.9	15.8	23.2	2.9	-4.8
Arm fat-free mass (left)	2.9	14.5	22.0	2.6	-4.7
Forced expiratory volume in 1-second (FEV1)	2.8	9.3	18.3	0.5	-4.3
Arm fat-free mass (right)	2.7	13.8	19.8	2.8	-4.5
Shortness of breath walking on level ground	2.7	3.2	3.2	1.8	1.8
Deep venous thrombosis (DVT) (self-reported)	2.7	3.5	6.4	2.5	0.8
Verbal and Numeric Reasoning (VNR)	2.6	6.2	8.6	-2.9	-1.9
Number of live births	2.6	3.7	7.4	2.7	-0.1
Serious illness, injury or assault of a close relative in last 2 years	2.6	3.0	4.9	-2.2	1.0
Exposure to tobacco smoke at home	2.6	2.9	3.3	1.6	1.8
Arm predicted mass (right)	2.6	13.5	18.7	2.9	-4.3
Fluid intelligence score	2.5	5.2	6.7	-2.6	-1.9
Commuting to job workplace: Walk	2.5	2.7	4.3	-2.1	1.0
Chronotype (morning person)	2.4	5.5	8.3	1.6	-2.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.4	5.0	9.1	-1.0	-3.0
Height	2.3	43.5	56.9	5.5	-7.5
Diabetes (father)	2.3	2.8	4.9	-2.2	-0.9
Age at last live birth	2.3	3.3	4.5	-1.4	-2.1
Mood swings	2.3	4.1	6.3	2.5	1.3
Miserableness	2.3	4.0	4.8	1.8	2.2
Triglycerides	2.2	3.6	4.9	1.5	2.2
Blood clot in the leg (DVT)	2.2	2.8	4.8	2.2	0.9
Mean time to correctly identify matches	2.2	4.2	4.6	2.1	2.0
Age at First Birth	2.1	3.1	4.5	-2.1	-1.3
Age when periods started (menarche)	2.1	5.1	8.7	1.2	3.0
Mouth/teeth dental problems	2.1	3.3	6.5	-2.6	0.1
Standing height	2.1	21.0	29.4	3.5	-5.4
Neuroticism	2.0	4.7	7.7	2.8	1.4
Sensitivity / hurt feelings	2.0	3.4	4.7	2.2	1.4
Medication for hormone replacement therapy	2.0	2.2	4.3	-2.1	-0.4
Heart disease (mother)	2.0	2.4	4.1	-2.0	0.8
Supplements: Vitamin C	2.0	2.4	3.7	-1.0	1.9
Neuroticism (Nagel 2018)	1.9	4.4	6.4	2.5	1.6
Father’s age at death	1.9	2.6	5.1	-2.3	-0.2
Alcohol drinker status: Never	1.9	2.3	3.2	1.8	-1.1
Bipolar Disorder (2011)	1.8	1.8	2.2	-1.2	1.5
Mouth/teeth dental problems: Loose teeth	1.8	2.1	3.9	2.0	0.6
HbA1C	1.7	1.9	3.5	0.6	1.9
Weight	1.7	8.3	8.4	2.9	-2.9
Hair/balding pattern: Pattern 3	1.7	2.5	4.4	-0.8	-2.1
Qualifications: A levels/AS levels or equivalent	1.7	3.8	7.1	-2.7	-0.6
Mouth/teeth dental problems: Dentures	1.7	2.9	5.5	2.3	-0.5
Breastfed as a baby	1.7	2.1	3.8	-1.9	-0.7
Commuting to job workplace: Public transport	1.7	2.0	3.9	-2.0	-0.4
Pain experienced in last month	1.7	2.8	5.6	-2.4	0.1
Angina	1.6	2.1	3.9	-0.6	2.0
Neuroticism score	1.6	3.4	3.8	1.9	1.7
Migraine (self-reported)	1.6	2.0	2.3	1.5	-1.3
Osteoarthritis (self-reported)	1.6	2.0	4.1	2.0	0.1
Impedance of leg (right)	1.5	7.5	12.5	-1.6	3.5
Leg pain on walking	1.5	1.9	2.0	1.4	-1.4
Unable to work because of sickness or disability	1.5	2.0	3.8	-0.5	-1.9
Alzheimer’s Disease (including proxy)	1.4	2.1	3.1	-1.0	-1.8
Mean Putamen Volume	1.4	1.6	1.6	-1.3	-1.2
Impedance of leg (left)	1.4	6.7	11.0	-1.6	3.3
Knee pain experienced in last month	1.4	2.1	4.2	2.0	-0.2
Loneliness, isolation	1.4	1.9	3.5	1.9	-0.6
Guilty feelings	1.4	2.1	4.0	-0.3	2.0
Medication: Paracetamol	1.4	2.2	2.9	1.7	-1.2
Number of treatments/medications taken	1.3	2.3	4.5	2.1	-0.3
Medication: Seretide 50 evohaler	1.3	1.5	2.8	0.4	-1.7
Impedance of whole body	1.3	6.6	12.3	-1.0	3.5
Irritable Bowel Disease (IBD)	1.2	2.9	5.5	-0.5	-2.4
Severe depression (siblings)	1.2	1.4	1.6	-1.3	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.0	1.7	0.4
Medication for pain relief, constipation, heartburn	1.2	2.1	3.1	-1.8	1.0
Handedness (chirality/laterality): Left-handed	1.2	1.5	2.9	-1.7	-0.3
Osteoporosis (self-reported)	1.2	1.4	2.0	0.9	1.4
Pain type(s) experienced in last month: Hip pain	1.2	1.5	2.9	1.7	0.2
Commuting to job workplace: Cycle	1.2	1.5	2.9	-0.0	-1.7
Depression (Nagel 2018)	1.1	1.6	2.0	1.4	1.1
Frequency of depressed mood in last 2 weeks	1.1	1.5	3.0	0.3	1.7
Other serious medical condition/disability diagnosed by doctor	1.1	1.5	2.3	-0.8	1.5
Ever had hysterectomy (womb removed)	1.1	1.2	2.3	1.5	-0.3
Nervous feelings	1.1	2.0	2.5	1.6	1.2
Financial difficulties in last 2 years	1.1	1.5	2.7	0.4	-1.7
Prospective memory result	1.1	1.4	2.2	1.5	0.7
Illnesses of mother	1.1	1.4	1.6	1.1	1.3
Loud music exposure frequency	1.1	1.2	1.8	-0.8	1.3
Pulse wave peak to peak time	1.1	1.3	2.3	0.5	-1.5
Angina (self-reported)	1.1	1.5	2.5	-0.7	1.6
Tinnitus: Yes, now most or all of the time	1.1	1.3	2.1	-0.8	1.4
Pack years of smoking	1.1	1.7	3.2	-0.3	1.8
Bipolar Disorder (2018)	1.0	1.6	3.1	-0.2	1.8
Prostate Cancer	1.0	1.4	2.8	-1.7	0.2
Pack years adult smoking proportion	1.0	1.5	2.6	-0.6	1.6
Taking other prescription medications	1.0	1.6	2.9	1.7	-0.5
Heart attack	1.0	1.3	2.0	-0.7	1.4
Pain all over the body in last month	1.0	1.0	2.0	-0.2	1.4
Medication: Ramipril	1.0	1.3	2.5	-1.6	-0.0
Worrier / anxious feelings	1.0	2.0	2.3	1.5	1.3
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.2	-1.8	-0.1
Medication: Paracetamol	1.0	1.6	3.1	1.8	-0.5
Medication: Ventolin 100micrograms inhaler	1.0	1.3	2.2	1.5	0.7
Commuting to job workplace: Car/motor vehicle	1.0	1.1	2.1	1.5	0.3
Average weekly red wine intake	1.0	1.4	2.6	-0.6	-1.6
Diastolic blood pressure, automated reading	1.0	3.2	5.5	-0.9	-2.3
Ulcerative Colitis (UC)	0.9	1.8	3.5	-0.1	-1.9
Major Depression (MDD)	0.9	1.1	1.2	1.0	-1.1
Heel T-Score	0.9	6.9	9.9	-3.1	-2.0
Systolic blood pressure, automated reading	0.9	2.6	4.5	-2.1	0.9
Supplements: Zinc	0.9	0.9	0.9	-1.0	1.0
Chronic bronchitis/emphysema (father)	0.9	1.1	2.0	1.4	0.4
Trunk fat mass	0.9	3.8	7.3	2.7	-0.6
Alcohol usually taken with meals	0.9	1.5	2.3	-1.5	-0.8
Illnesses of siblings	0.9	1.2	2.3	-0.3	-1.5
Impedance of arm (left)	0.9	4.3	8.4	0.4	2.9
Peak expiratory flow (PEF)	0.9	2.1	2.3	-1.5	-1.4
Whole body fat mass	0.9	3.7	6.7	2.6	-0.8
Had major operations	0.9	1.0	1.3	-1.2	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.0	1.9	-1.4	0.4
Ever smoked	0.9	1.6	3.1	-1.8	0.3
Schizophrenia vs Biploar Disorder	0.8	1.0	1.5	-1.2	-0.8
Ulcerative Colitis	0.8	1.1	2.1	0.4	-1.4
Blood Platelet Count	0.8	8.9	17.8	-0.1	4.2
Townsend deprivation index at recruitment	0.8	1.2	1.9	-0.6	1.4
Frequency of tiredness / lethargy in last 2 weeks	0.8	1.3	2.6	-0.2	1.6
Pulse rate	0.8	1.4	1.4	-1.2	-1.2
Medication: Ibuprofen (e.g. Nurofen)	0.8	1.0	1.6	0.5	-1.3
Depression (self-reported)	0.8	0.9	1.5	-1.2	0.6
Pulse wave Arterial Stiffness index	0.8	0.9	1.5	-0.5	1.2
Alcohol intake frequency.	0.8	1.9	3.2	1.8	-0.7
Number of full sisters	0.8	1.0	1.2	-0.9	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	3.3	-0.3	-1.8
Breast cancer (self-reported)	0.8	0.9	1.6	1.3	0.5
Arm fat mass (left)	0.8	3.2	5.4	2.3	-0.9
Wears glasses or contact lenses	0.8	0.9	1.4	-1.2	0.6
Ever had prostate specific antigen (PSA) test	0.8	0.9	0.9	-0.9	-1.0
Breast Cancer	0.7	1.6	2.7	-1.6	0.7
Fasting Glucose	0.7	0.9	1.7	1.3	-0.1
Hearing difficulty/problems: Yes	0.7	1.0	1.1	-1.0	-1.0
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	1.5	-0.2	1.2
Trunk fat percentage	0.7	2.9	4.9	2.2	0.9
Current tobacco smoking	0.7	1.2	2.3	0.2	1.5
Tinnitus: Yes, but not now, but have in the past	0.7	0.7	1.4	-1.2	0.0
Serious illness, injury or assault to yourself	0.7	0.8	1.5	-1.2	0.3
Time employed in main current job	0.7	0.8	1.4	1.2	-0.5
Arm fat mass (right)	0.7	3.0	4.9	2.2	-1.0
Tense / ‘highly strung’	0.7	1.1	1.8	1.4	0.6
Birth weight of first child	0.7	1.3	1.7	1.0	-1.3
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.2	1.1	0.8
Number of children fathered	0.7	0.8	1.5	1.2	0.1
Medication: Ibuprofen	0.7	0.8	0.9	0.9	-0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.3	1.1	-0.6
Leg fat mass (right)	0.7	2.5	4.4	2.1	-0.8
Friendships satisfaction	0.7	0.9	1.0	-1.0	0.9
Medication for cholesterol	0.7	1.0	2.1	1.4	0.1
Ever depressed for a whole week	0.7	0.9	1.3	-0.7	1.1
Heart attack/myocardial infarction (self-reported)	0.7	0.9	1.2	-0.8	1.1
Leg fat mass (left)	0.7	2.7	4.3	2.1	-1.0
Schizophrenia (2018)	0.6	1.3	2.4	-1.5	-0.5
Crohns Disease (2017)	0.6	1.3	2.0	-0.8	-1.4
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	1.4	1.2	0.6
Impedance of arm (right)	0.6	2.6	4.7	-0.7	2.2
Falls in the last year	0.6	0.8	1.1	0.7	1.1
Medication: Cholesterol lowering	0.6	0.9	1.9	-0.1	1.4
Medication: Lansoprazole	0.6	0.7	0.9	1.0	0.7
Gout (self-reported)	0.6	0.8	1.1	0.6	1.1
Birth weight	0.6	1.4	1.7	-1.1	1.3
Exposure to tobacco smoke outside home	0.6	0.7	0.9	0.8	0.9
Medication: Gliclazide	0.6	0.7	1.2	0.3	-1.1
Eye problems/disorders: Glaucoma	0.6	0.7	1.4	-0.0	1.2
Illnesses of father: High blood pressure	0.6	0.8	1.5	-1.2	-0.2
Fractured/broken bones in last 5 years	0.6	0.8	1.6	1.3	0.0
Bipolar Disorder or Schizophrenia	0.5	1.1	1.7	-1.3	0.7
HDL Cholesterol	0.5	0.8	1.6	0.1	-1.2
Lung FEV1/FVC ratio	0.5	2.6	2.9	-1.5	1.7
Relative age voice broke	0.5	0.7	1.3	1.2	-0.3
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.1	0.2	-1.4
Medication: Atenolol	0.5	0.6	1.1	-1.1	0.0
High blood pressure (mother)	0.5	0.7	1.4	-1.2	-0.1
Waist circumference	0.5	2.0	3.9	2.0	0.0
Past tobacco smoking	0.5	0.8	1.5	1.2	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.2	2.3	-1.5	0.4
Diabetes (self-reported)	0.5	0.8	1.4	-0.4	-1.2
Asthma	0.5	0.9	0.9	0.9	-1.0
Body fat percentage	0.5	2.0	3.2	1.8	0.9
Emphysema/chronic bronchitis	0.5	0.6	0.7	0.7	0.9
Medication: Allopurinol	0.5	0.6	0.8	0.7	0.9
Arm fat percentage (left)	0.5	2.0	3.3	1.8	0.8
Ever had bowel cancer screening	0.5	0.5	1.0	1.0	0.3
Back pain experienced in last month	0.5	0.7	1.3	1.2	0.2
Financial situation satisfaction	0.5	0.6	0.7	-0.8	-0.7
High cholesterol (Self-reported)	0.5	0.9	1.8	-0.2	1.4
Risk taking	0.5	0.8	1.3	-0.5	-1.1
Age started oral contraceptive pill	0.5	0.6	1.1	-0.4	1.0
Cholesterol lowering medication	0.5	0.7	1.3	-0.2	1.1
Reaction Time	0.4	0.7	0.8	0.8	0.9
Crohns Disease (2012)	0.4	0.7	1.0	-0.5	-1.0
Lupus	0.4	0.7	1.2	1.1	-0.5
Type 2 Diabetes (T2D) (2012)	0.4	0.5	0.8	-0.9	0.4
Smoking Status	0.4	0.9	1.1	-0.8	1.0
Respiratory disease	0.4	0.8	1.6	1.3	0.0
Average weekly spirits intake	0.4	0.5	0.8	-0.4	0.9
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.0	0.3	1.0
Medication: Metformin	0.4	0.5	1.0	1.0	-0.3
Diabetes (mother)	0.4	0.6	1.1	1.1	-0.0
Supplements: Glucosamine	0.4	0.6	1.0	-1.0	-0.4
Had menopause	0.4	0.5	0.9	0.4	1.0
Medication: Simvastatin	0.4	0.6	1.1	0.0	1.1
Hip circumference	0.4	1.8	2.7	1.6	-0.9
Happiness	0.4	0.4	0.7	0.3	0.9
Pulse wave reflection index	0.4	0.5	0.6	-0.7	-0.7
Worry too long after embarrassment	0.4	0.7	1.4	0.1	1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.0	0.2	1.0
Wheeze or whistling in the chest in last year	0.4	0.6	0.7	0.8	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.9	0.4	1.0
Medication: Omeprazole	0.4	0.5	0.6	-0.6	-0.7
Medication: Blood pressure	0.4	0.7	1.4	-1.2	-0.3
Medication: Atorvastatin	0.4	0.4	0.6	0.5	-0.8
Irritability	0.4	0.7	1.0	-0.6	1.0
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	-0.3	-0.9
Alzheimer’s Disease (in father)	0.3	0.3	0.5	0.3	-0.7
Coronary Artery Disease (CAD)	0.3	0.3	0.4	0.5	-0.6
Neuroticism (2016)	0.3	0.5	0.5	0.7	0.7
BMI	0.3	1.5	2.3	1.5	-0.8
Waist Hip Ratio (WHR)	0.3	1.5	2.2	0.9	1.5
Relative age of first facial hair	0.3	0.6	1.2	-0.1	1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.0	-1.0	0.4
High blood pressure	0.3	1.0	1.1	-1.1	-0.9
Medication: Levothyroxine sodium	0.3	0.4	0.8	-0.2	0.9
Body mass index (BMI)	0.3	1.2	2.2	1.5	-0.5
Had other major operations	0.3	0.4	0.4	0.6	-0.6
Allergy	0.3	0.8	1.2	-0.6	1.1
Arm fat percentage (right)	0.3	1.2	2.0	1.4	0.6
Hair/balding pattern: Pattern 4	0.3	0.7	1.4	-0.3	-1.2
Headache pain in last month	0.3	0.5	0.8	0.9	-0.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	0.5	-0.6	-0.7
Medication: Amlodipine	0.3	0.4	0.7	0.9	-0.3
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.5	0.7	-0.3
Leg fat percentage (right)	0.3	1.0	1.4	0.8	1.2
Family relationship satisfaction	0.3	0.3	0.4	0.6	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	0.4	0.6	0.5
Hypertension (Self-reported)	0.3	0.8	0.9	-0.9	-0.8
Long-standing illness, disability or infirmity	0.3	0.5	0.8	0.5	-0.9
Diabetes diagnosed by doctor	0.3	0.5	0.7	-0.6	-0.9
Asthma (self-reported)	0.3	0.7	0.7	0.8	-0.8
Medication: Aspirin	0.3	0.3	0.4	0.5	-0.6
Number of self-reported non-cancer illnesses	0.3	0.5	0.8	0.4	0.9
Average weekly champagne plus white wine intake	0.3	0.4	0.7	0.4	-0.8
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.6	-0.4	-0.8
Medication: Bendroflumethiazide	0.3	0.4	0.8	-0.9	-0.2
Number of operations (self-reported)	0.3	0.4	0.8	0.1	0.9
Worry (Nagel 2018)	0.2	0.5	0.7	0.8	0.5
Primary Biliary Cirrhosis	0.2	0.3	0.6	-0.8	-0.2
Rheumatoid Arthritis	0.2	0.2	0.3	0.5	-0.5
Schizophrenia (2014)	0.2	0.4	0.8	-0.9	0.1
Allergy or Eczema	0.2	0.6	1.1	0.2	-1.0
Hypothyroidism (self reported)	0.2	0.4	0.4	0.6	0.6
Type 2 Diabetes (T2D) (2018)	0.2	0.3	0.6	0.1	-0.8
Tanning	0.2	2.2	2.5	1.4	-1.6
Vitamin and mineral supplements	0.2	0.3	0.3	0.6	-0.6
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	0.2	0.4	-0.5
Qualifications: CSEs or equivalent	0.2	0.3	0.6	0.8	0.0
Multivitamins +/- minerals	0.2	0.2	0.3	-0.2	-0.6
Lung cancer (father)	0.2	0.3	0.4	0.4	0.6
Glaucoma (self-reported)	0.2	0.2	0.3	-0.4	0.5
Neck or shoulder pain in last month	0.2	0.3	0.4	-0.5	-0.7
Pulse rate, automated reading	0.2	0.5	1.0	-0.2	-1.0
Overall health rating	0.2	0.4	0.9	0.9	0.1
Chest pain or discomfort	0.2	0.3	0.7	0.8	-0.0
Medication: Aspirin	0.2	0.2	0.4	0.0	-0.7
Smoking status: Previous	0.2	0.3	0.6	-0.8	-0.2
Mouth/teeth dental problems: Mouth ulcers	0.2	0.3	0.6	-0.3	-0.7
Mineral and other dietary supplements	0.2	0.3	0.6	0.8	0.3
Illnesses of father: None of the above (group 1)	0.2	0.3	0.4	-0.3	0.7
Smoking status: Current	0.2	0.3	0.6	-0.2	0.8
Medication: Lisinopril	0.2	0.3	0.5	-0.7	-0.3
Leg fat percentage (left)	0.2	0.8	0.9	1.0	0.8
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.2	1.1	-0.3
Basal cell carcinoma (self-reported)	0.2	0.2	0.4	-0.6	-0.0
Ovarian Cancer	0.1	0.1	0.1	0.3	-0.2
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	0.4	0.1
Blood Eosinophil Count	0.1	0.7	1.5	-1.2	0.0
Blood Red Count	0.1	1.4	1.5	1.2	-1.1
Blood White Count	0.1	1.1	1.8	1.4	0.5
Hair Pigment	0.1	2.7	5.4	2.3	-0.1
Medication: Co-codamol	0.1	0.1	0.2	0.4	0.1
Average weekly fortified wine intake	0.1	0.2	0.2	-0.3	0.5
Hearing difficulty/problems with background noise	0.1	0.1	0.2	-0.4	0.3
Alcohol intake versus 10 years previously	0.1	0.1	0.1	-0.2	0.4
Noisy workplace	0.1	0.2	0.2	0.5	-0.3
Length of working week for main job	0.1	0.1	0.1	-0.3	0.3
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	-0.2	-0.3
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.2	0.4	0.5
High blood pressure (siblings)	0.1	0.1	0.1	0.2	0.4
Comparative body size at age 10	0.1	0.4	0.8	-0.9	0.1
Medication: Blood pressure	0.1	0.2	0.5	-0.1	-0.7
Illnesses of father: Heart disease	0.1	0.1	0.3	-0.5	-0.1
Illnesses of siblings: Diabetes	0.1	0.2	0.3	-0.1	0.6
Hearing aid user	0.1	0.1	0.1	-0.2	0.3
Mother’s age at death	0.1	0.1	0.2	-0.4	0.2
Average weekly beer plus cider intake	0.1	0.2	0.4	0.1	-0.6
Supplements: Calcium	0.1	0.1	0.2	0.1	-0.4
Alcohol drinker status: Previous	0.1	0.1	0.1	0.3	-0.3
Cardiovascular Disease	0.0	0.1	0.1	-0.2	0.2
Maternal smoking around birth	0.0	0.0	0.0	0.1	-0.0
Stomach or abdominal pain in last month	0.0	0.0	0.0	0.1	-0.1
Hayfever/allergic rhinitis (self-reported)	0.0	0.0	0.0	-0.2	-0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.1	0.3	0.0
Health satisfaction	0.0	0.1	0.1	0.2	-0.2
Suffer from ‘nerves’	0.0	0.0	0.1	-0.0	-0.3
Illness, injury, bereavement, stress in last 2 years	0.0	0.1	0.1	0.2	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.0	0.0	0.1	0.2	0.0
Myopia	0.0	0.0	0.1	0.3	-0.1

Hub : Genes

HIGD1B

Models

Trait associations