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chr12:109,231,851-113,517,494

Best TWAS P=1.62e-15 · Best GWAS P=1.05e-21 conditioned to 0.2

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	HECTD4	0.06	0.00	enet	15	0.02	1.0e-02	3.3	-6.3	3.5e-10	0.65	0.06	0.84	FALSE
2	GTEx	Adrenal Gland	PPTC7	0.13	-0.01	lasso	6	0.00	3.4e-01	4.5	5.7	1.5e-08	-0.26	0.03	0.15	FALSE
3	GTEx	Artery Tibial	VPS29	0.05	0.03	lasso	3	0.02	5.9e-03	5.3	5.5	5.0e-08	-0.11	0.06	0.79	FALSE
4	GTEx	Artery Tibial	HECTD4	0.05	0.02	lasso	3	0.01	3.1e-02	-8.5	-8.0	1.6e-15	0.78	0.02	0.92	TRUE
5	GTEx	Breast Mammary Tissue (Female)	VPS29	0.10	-0.01	lasso	2	0.02	1.0e-01	-4.7	5.9	2.8e-09	-0.34	0.03	0.18	TRUE
6	GTEx	Colon Transverse	FAM109A	0.21	0.00	lasso	4	0.01	1.3e-01	5.2	-6.0	1.7e-09	0.41	0.06	0.06	FALSE
7	GTEx	Muscle Skeletal	VPS29	0.06	0.06	lasso	3	0.05	4.3e-06	5.3	5.3	1.5e-07	-0.09	0.04	0.96	FALSE
8	GTEx	Nerve Tibial	HECTD4	0.05	0.01	enet	6	0.01	3.6e-02	5.8	-5.8	5.2e-09	0.41	0.22	0.46	FALSE
9	GTEx	Skin Not Sun Exposed Suprapubic	VPS29	0.06	0.01	lasso	3	0.01	6.9e-02	4.6	5.2	1.9e-07	-0.07	0.08	0.35	FALSE
10	GTEx	Skin Sun Exposed Lower leg	ALDH2	0.10	0.09	enet	13	0.13	6.7e-11	3.1	-6.2	7.5e-10	0.62	0.84	0.16	FALSE
11	GTEx	Thyroid	BRAP	0.07	0.02	lasso	7	0.03	1.1e-03	3.2	5.3	1.3e-07	-0.54	0.31	0.50	FALSE
12	GTEx	Thyroid	VPS29	0.07	0.01	lasso	5	0.01	8.9e-02	4.9	5.6	2.6e-08	-0.11	0.05	0.56	FALSE
13	NTR	Blood	ALDH2	0.06	0.01	blup	222	0.02	4.3e-08	4.2	6.3	2.7e-10	-0.43	0.86	0.13	FALSE
14	NTR	Blood	GPN3	0.03	0.01	blup	236	0.02	2.7e-06	4.5	-5.3	1.1e-07	0.12	0.27	0.71	FALSE
15	NTR	Blood	UBE3B	0.09	0.05	lasso	8	0.08	1.0e-25	4.8	5.5	4.8e-08	0.04	0.19	0.80	TRUE
16	YFS	Blood	SH2B3	0.05	0.01	enet	22	0.02	3.3e-07	3.2	-5.9	3.2e-09	0.64	0.67	0.33	FALSE
17	YFS	Blood	TRAFD1	0.04	0.02	lasso	2	0.01	2.9e-05	-4.3	-5.5	5.0e-08	0.55	0.09	0.85	FALSE
18	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	KCTD10	0.06	0.00	lasso	3	0.00	1.4e-01	4.8	-5.4	5.1e-08	-0.05	0.00	0.44	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	VPS29	0.02	0.02	lasso	5	0.03	4.6e-06	4.9	5.1	3.0e-07	-0.07	0.00	0.99	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACAD10	0.02	0.02	lasso	3	0.01	7.0e-03	5.8	5.8	7.0e-09	-0.50	0.01	0.90	FALSE
21	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ERP29	0.11	0.03	blup	25	0.05	5.0e-03	3.3	5.2	2.2e-07	-0.60	0.01	0.75	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	CUX2	0.08	0.01	blup	95	0.02	1.3e-03	4.7	6.5	9.2e-11	-0.15	0.06	0.64	TRUE
23	The Cancer Genome Atlas	Prostate Adenocarcinoma	MMAB	0.06	0.06	blup	57	0.06	5.4e-07	-4.2	-5.3	1.4e-07	-0.06	0.57	0.42	FALSE