Best TWAS P=2.57e-17 · Best GWAS P=5.03e-17 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RAVER1 | 0.06 | 0.03 | bslmm | 388 | 0.04 | 2.5e-05 | -1.86 | -5.6 | 2.0e-08 | -0.48 | 0.20 | 0.34 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | S1PR2 | 0.07 | 0.02 | bslmm | 369 | 0.03 | 5.3e-05 | -5.29 | 5.7 | 1.6e-08 | 0.31 | 0.32 | 0.14 | FALSE |
| 3 | GTEx | Esophagus Mucosa | SLC44A2 | 0.13 | 0.00 | lasso | 6 | 0.02 | 1.4e-02 | 4.86 | -6.1 | 1.2e-09 | -0.46 | 0.07 | 0.58 | FALSE |
| 4 | GTEx | Esophagus Mucosa | ILF3-AS1 | 0.11 | 0.00 | lasso | 4 | 0.00 | 2.5e-01 | 8.31 | -6.7 | 1.6e-11 | -0.77 | 0.02 | 0.88 | FALSE |
| 5 | GTEx | Muscle Skeletal | SLC44A2 | 0.19 | 0.18 | lasso | 5 | 0.19 | 5.1e-18 | 6.98 | 7.5 | 4.6e-14 | 0.79 | 0.83 | 0.17 | FALSE |
| 6 | GTEx | Nerve Tibial | ILF3-AS1 | 0.14 | 0.04 | lasso | 3 | 0.08 | 3.8e-06 | 8.26 | -7.0 | 3.0e-12 | -0.77 | 0.01 | 0.98 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | SMARCA4 | 0.15 | 0.10 | enet | 25 | 0.15 | 1.4e-12 | 2.57 | -5.4 | 5.2e-08 | -0.61 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Testis | PDE4A | 0.20 | 0.02 | enet | 39 | 0.04 | 6.4e-03 | 5.30 | 6.2 | 4.7e-10 | 0.06 | 0.06 | 0.04 | TRUE |
| 9 | GTEx | Vagina | CTD-2369P2.2 | 0.50 | -0.01 | lasso | 9 | 0.01 | 2.0e-01 | 5.28 | 5.5 | 4.0e-08 | 0.01 | 0.22 | 0.11 | TRUE |
| 10 | GTEx | Whole Blood | CTD-2369P2.8 | 0.12 | 0.11 | lasso | 3 | 0.10 | 9.2e-10 | 6.00 | 6.5 | 8.5e-11 | 0.06 | 1.00 | 0.00 | TRUE |
| 11 | NTR | Blood | SMARCA4 | 0.07 | 0.06 | lasso | 11 | 0.06 | 9.0e-18 | 5.06 | -5.5 | 3.9e-08 | -0.43 | 1.00 | 0.00 | FALSE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | ILF3-AS1 | 0.15 | 0.04 | bslmm | 354 | 0.18 | 7.1e-22 | -0.54 | -5.1 | 2.9e-07 | -0.61 | 0.05 | 0.95 | FALSE |
| 13 | The Cancer Genome Atlas | Breast Invasive Carcinoma | S1PR2 | 0.02 | 0.00 | blup | 32 | 0.01 | 1.5e-02 | -5.77 | 5.8 | 8.2e-09 | 0.04 | 0.00 | 0.64 | TRUE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | FDX1L | 0.06 | 0.02 | lasso | 3 | 0.04 | 2.4e-05 | -4.32 | -5.5 | 3.9e-08 | -0.04 | 0.20 | 0.18 | TRUE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LOC147727 | 0.13 | 0.02 | blup | 28 | 0.04 | 7.2e-05 | 8.28 | -6.4 | 1.9e-10 | -0.76 | 0.01 | 0.90 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FDX1L | 0.06 | 0.00 | blup | 53 | 0.02 | 5.1e-03 | -4.32 | -5.9 | 2.8e-09 | 0.05 | 0.01 | 0.09 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LOC147727 | 0.07 | 0.02 | lasso | 2 | 0.02 | 5.4e-03 | 8.31 | -8.5 | 2.6e-17 | -0.99 | 0.01 | 0.86 | TRUE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC44A2 | 0.32 | 0.22 | enet | 14 | 0.25 | 3.8e-24 | 7.92 | 6.3 | 2.3e-10 | 0.85 | 0.20 | 0.80 | FALSE |