[Hub]/) : Traits : Whole body water mass :

chr4:305,291-2,437,290

Best TWAS P=3.3e-17 · Best GWAS P=1.76e-15 conditioned to 0.000432

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CRIPAK 0.31 0.15 enet 34 0.26 1.2e-31 -4.59 -6.7 3.0e-11 0.04 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous CRIPAK 0.42 0.11 enet 42 0.34 9.0e-29 -4.61 -6.1 1.2e-09 0.04 1.00 0.00 FALSE
3 GTEx Adipose Visceral Omentum UVSSA 0.46 0.05 lasso 11 0.24 1.1e-12 -5.44 -6.1 1.2e-09 0.01 0.79 0.11 FALSE
4 GTEx Adipose Visceral Omentum CRIPAK 0.47 0.24 lasso 12 0.31 1.3e-16 -4.91 -6.5 8.5e-11 0.02 1.00 0.00 FALSE
5 GTEx Artery Aorta UVSSA 0.33 0.06 enet 30 0.28 7.2e-16 -5.44 -6.2 7.9e-10 0.01 0.15 0.84 FALSE
6 GTEx Artery Aorta CRIPAK 0.31 0.20 enet 34 0.30 2.8e-17 -4.91 -6.0 1.7e-09 0.01 0.99 0.00 FALSE
7 GTEx Artery Tibial CRIPAK 0.42 0.09 enet 50 0.34 1.3e-27 1.79 -5.5 4.0e-08 0.02 1.00 0.00 FALSE
8 GTEx Brain Caudate basal ganglia CRIPAK 0.27 0.00 lasso 2 0.02 9.3e-02 -5.44 -6.1 1.4e-09 0.01 0.06 0.06 FALSE
9 GTEx Brain Cerebellum CRIPAK 0.37 0.09 enet 24 0.31 8.8e-10 -4.67 -6.4 2.0e-10 -0.01 0.37 0.11 FALSE
10 GTEx Brain Cortex TACC3 0.26 0.13 lasso 4 0.17 1.7e-05 -6.51 6.0 1.9e-09 0.52 0.25 0.26 FALSE
11 GTEx Brain Cortex CRIPAK 0.34 0.10 lasso 6 0.18 9.5e-06 -4.91 -7.3 2.4e-13 0.03 0.17 0.19 FALSE
12 GTEx Brain Hippocampus CRIPAK 0.48 0.22 lasso 4 0.23 4.0e-06 -4.90 -7.5 8.0e-14 0.00 0.17 0.18 FALSE
13 GTEx Brain Hypothalamus CRIPAK 0.22 0.00 lasso 5 0.01 2.1e-01 -5.44 -6.3 3.6e-10 0.02 0.06 0.08 FALSE
14 GTEx Brain Nucleus accumbens basal ganglia UVSSA 0.24 0.00 enet 33 0.04 2.8e-02 0.72 -5.7 1.4e-08 -0.10 0.07 0.06 FALSE
15 GTEx Brain Nucleus accumbens basal ganglia CRIPAK 0.34 0.13 lasso 6 0.25 2.7e-07 -4.91 -6.3 2.6e-10 0.05 0.20 0.07 FALSE
16 GTEx Brain Putamen basal ganglia CRIPAK 0.30 0.00 enet 25 0.10 1.9e-03 -4.14 -6.5 9.6e-11 0.11 0.05 0.15 FALSE
17 GTEx Breast Mammary Tissue CRIPAK 0.42 0.12 enet 35 0.39 5.2e-21 -4.91 -6.2 6.5e-10 0.02 1.00 0.00 FALSE
18 GTEx Breast Mammary Tissue (Female) CRIPAK 0.32 0.17 enet 29 0.26 2.7e-08 -4.63 -7.2 4.6e-13 0.01 0.53 0.04 FALSE
19 GTEx Cells EBV-transformed lymphocytes CRIPAK 0.49 0.27 lasso 8 0.35 2.9e-12 -4.91 -6.2 5.1e-10 0.05 0.84 0.01 FALSE
20 GTEx Colon Sigmoid CRIPAK 0.40 0.21 lasso 7 0.30 4.7e-11 -5.57 -6.0 2.0e-09 0.06 0.72 0.02 FALSE
21 GTEx Colon Transverse TMEM129 0.23 0.05 lasso 4 0.03 1.8e-02 -6.51 6.7 1.6e-11 0.51 0.09 0.09 FALSE
22 GTEx Colon Transverse CRIPAK 0.33 0.10 enet 22 0.24 5.8e-12 -4.90 -6.2 6.6e-10 0.03 0.97 0.00 FALSE
23 GTEx Colon Transverse RP11-20I20.4 0.17 0.05 lasso 3 0.05 2.3e-03 -5.57 -5.9 2.8e-09 0.01 0.43 0.02 FALSE
24 GTEx Esophagus Gastroesophageal Junction UVSSA 0.30 0.00 enet 23 0.08 1.1e-03 -4.91 -5.6 1.9e-08 0.09 0.28 0.04 FALSE
25 GTEx Esophagus Gastroesophageal Junction CRIPAK 0.33 0.20 lasso 5 0.30 1.4e-11 -4.91 -5.9 2.8e-09 0.02 0.99 0.00 FALSE
26 GTEx Esophagus Mucosa CRIPAK 0.49 0.14 enet 28 0.40 6.8e-29 -4.91 -6.2 6.8e-10 0.00 0.97 0.03 FALSE
27 GTEx Esophagus Muscularis UVSSA 0.35 0.03 enet 33 0.16 3.5e-10 -4.91 -5.5 4.0e-08 0.03 0.92 0.02 FALSE
28 GTEx Esophagus Muscularis CRIPAK 0.38 0.14 enet 34 0.30 2.6e-18 -4.91 -6.0 2.3e-09 0.05 1.00 0.00 FALSE
29 GTEx Heart Atrial Appendage CRIPAK 0.31 0.26 enet 23 0.33 2.1e-15 -4.91 -6.2 5.6e-10 0.03 1.00 0.00 FALSE
30 GTEx Lung CRIPAK 0.61 0.22 enet 46 0.41 1.1e-33 -4.91 -7.7 1.8e-14 0.02 1.00 0.00 FALSE
31 GTEx Lung RP11-20I20.4 0.07 0.00 lasso 3 0.01 6.0e-02 -5.57 -6.2 4.3e-10 0.03 0.14 0.03 FALSE
32 GTEx Muscle Skeletal FGFRL1 0.14 0.08 lasso 4 0.06 3.7e-06 -7.62 7.1 1.6e-12 0.01 0.00 1.00 TRUE
33 GTEx Muscle Skeletal CRIPAK 0.25 0.11 enet 32 0.18 7.6e-18 -4.91 -6.6 3.8e-11 0.03 1.00 0.00 FALSE
34 GTEx Nerve Tibial CRIPAK 0.50 0.11 enet 76 0.38 1.1e-28 -4.90 -7.5 6.7e-14 -0.08 1.00 0.00 FALSE
35 GTEx Ovary UVSSA 0.33 0.10 enet 12 0.32 1.5e-08 -5.44 -5.8 5.4e-09 0.02 0.10 0.09 FALSE
36 GTEx Ovary CRIPAK 0.43 0.27 enet 19 0.32 9.0e-09 -4.91 -6.7 2.4e-11 0.03 0.45 0.08 FALSE
37 GTEx Pancreas TMEM129 0.20 0.19 lasso 3 0.14 1.5e-06 -6.51 6.1 9.1e-10 0.58 0.88 0.04 FALSE
38 GTEx Pancreas CRIPAK 0.34 0.13 lasso 6 0.27 1.0e-11 -4.90 -6.8 1.2e-11 0.01 0.83 0.02 FALSE
39 GTEx Skin Not Sun Exposed Suprapubic CRIPAK 0.39 0.14 lasso 13 0.34 1.5e-19 -4.91 -5.5 3.4e-08 0.01 0.82 0.17 FALSE
40 GTEx Skin Sun Exposed Lower leg CRIPAK 0.36 0.09 enet 40 0.35 8.7e-30 -4.61 -5.7 1.1e-08 0.03 1.00 0.00 FALSE
41 GTEx Spleen AC016773.1 0.42 0.21 lasso 7 0.16 8.6e-05 -6.63 5.2 2.0e-07 0.50 0.11 0.13 FALSE
42 GTEx Stomach CRIPAK 0.43 0.22 enet 46 0.35 1.4e-17 -4.91 -5.3 1.3e-07 0.06 1.00 0.00 FALSE
43 GTEx Thyroid TMEM129 0.44 0.31 lasso 7 0.34 1.2e-26 -3.79 5.5 4.2e-08 0.46 1.00 0.00 FALSE
44 GTEx Thyroid AC016773.1 0.11 0.07 enet 7 0.06 3.9e-05 -6.63 6.2 6.8e-10 0.52 0.67 0.04 FALSE
45 GTEx Uterus CRIPAK 0.52 0.34 lasso 3 0.33 1.7e-07 -5.44 -5.8 4.8e-09 0.01 0.23 0.06 FALSE
46 GTEx Whole Blood TACC3 0.11 0.05 enet 7 0.06 2.8e-06 -4.03 6.0 1.7e-09 0.59 0.93 0.03 FALSE
47 GTEx Whole Blood CRIPAK 0.38 0.17 lasso 9 0.28 3.4e-26 -4.90 -6.7 1.9e-11 0.02 1.00 0.00 FALSE
48 GTEx Whole Blood AC016773.1 0.27 0.21 enet 8 0.22 1.2e-19 -6.51 6.2 6.5e-10 0.53 0.98 0.02 FALSE
49 METSIM Adipose CRIPAK 0.28 0.16 bslmm 335 0.25 2.7e-37 -4.71 -7.6 2.3e-14 -0.01 1.00 0.00 FALSE
50 METSIM Adipose TMEM129 0.11 0.09 lasso 8 0.09 3.3e-13 -6.48 6.1 8.7e-10 0.57 0.98 0.02 FALSE
51 METSIM Adipose UVSSA 0.26 0.04 bslmm 366 0.12 9.0e-18 1.57 -6.6 3.3e-11 0.02 0.94 0.06 FALSE
52 NTR Blood CRIPAK 0.13 0.09 enet 31 0.15 1.5e-46 -4.37 -8.4 3.3e-17 0.00 1.00 0.00 TRUE
53 NTR Blood KIAA1530 0.19 0.04 blup 345 0.10 9.1e-32 -5.44 -7.7 1.3e-14 0.08 0.99 0.01 FALSE
54 NTR Blood SLBP 0.04 0.02 lasso 5 0.02 2.8e-08 -6.63 7.4 1.6e-13 0.82 0.03 0.97 FALSE
55 NTR Blood TACC3 0.05 0.03 lasso 9 0.04 2.7e-13 -6.48 7.7 1.8e-14 0.71 0.49 0.51 TRUE
56 ROSMAP Brain Pre-frontal Cortex UVSSA 0.31 0.05 blup 350 0.23 7.1e-29 1.57 -5.8 8.0e-09 -0.05 0.48 0.52 FALSE
57 ROSMAP Brain Pre-frontal Cortex CRIPAK 0.31 0.23 lasso 12 0.40 6.4e-55 -4.71 -5.9 3.8e-09 0.01 1.00 0.00 FALSE
58 ROSMAP Brain Pre-frontal Cortex AC016773.1 0.12 0.06 lasso 3 0.10 3.0e-12 -6.63 6.1 1.3e-09 0.52 0.99 0.01 FALSE
59 YFS Blood CRIPAK 0.35 0.27 bslmm 301 0.33 6.0e-112 -4.90 -7.0 2.6e-12 -0.03 1.00 0.00 FALSE
60 YFS Blood SLBP 0.10 0.12 lasso 3 0.12 1.2e-35 -6.48 6.5 1.0e-10 0.60 0.98 0.02 FALSE
61 The Cancer Genome Atlas Bladder Urothelial Carcinoma CRIPAK 0.11 0.07 lasso 4 0.05 2.0e-05 -4.90 -5.3 1.1e-07 0.00 0.00 0.99 FALSE
62 The Cancer Genome Atlas Breast Invasive Carcinoma CRIPAK 0.22 0.11 blup 28 0.14 5.6e-28 -4.90 -6.7 1.8e-11 0.01 0.00 0.99 FALSE
63 The Cancer Genome Atlas Breast Invasive Carcinoma KIAA1530 0.13 0.01 blup 48 0.03 4.9e-07 -4.67 -6.0 2.2e-09 -0.05 0.01 0.98 FALSE
64 The Cancer Genome Atlas Colon Adenocarcinoma CRIPAK 0.38 0.16 blup 28 0.21 2.8e-12 -4.90 -6.0 1.9e-09 0.01 0.00 0.99 FALSE
65 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CRIPAK 0.28 0.16 blup 28 0.19 3.2e-21 -4.90 -6.3 2.4e-10 0.03 0.00 0.99 FALSE
66 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CRIPAK 0.21 0.10 enet 9 0.15 1.3e-16 -4.90 -5.8 4.8e-09 0.00 0.00 0.99 FALSE
67 The Cancer Genome Atlas Brain Lower Grade Glioma CRIPAK 0.31 0.11 enet 10 0.18 1.5e-19 -4.90 -6.1 8.1e-10 -0.03 0.00 0.99 FALSE
68 The Cancer Genome Atlas Liver Hepatocellular Carcinoma CRIPAK 0.13 0.06 blup 29 0.08 1.2e-04 -4.90 -5.5 4.3e-08 0.01 0.00 0.91 FALSE
69 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CRIPAK 0.14 0.05 lasso 4 0.07 6.1e-08 -4.90 -5.3 1.1e-07 0.01 0.00 0.99 FALSE
70 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma CRIPAK 0.41 0.10 lasso 4 0.08 5.2e-04 -4.90 -5.5 3.3e-08 0.02 0.00 0.92 FALSE
71 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma TACC3 0.09 0.08 enet 7 0.11 2.7e-05 -6.48 6.1 1.4e-09 0.52 0.13 0.21 FALSE
72 The Cancer Genome Atlas Prostate Adenocarcinoma CRIPAK 0.27 0.17 enet 4 0.18 2.7e-18 -4.90 -5.2 1.6e-07 0.00 0.00 0.99 FALSE
73 The Cancer Genome Atlas Rectum Adenocarcinoma CRIPAK 0.37 0.07 lasso 2 0.12 1.2e-03 -4.90 -5.8 7.1e-09 0.03 0.00 0.61 FALSE
74 The Cancer Genome Atlas Soft Tissue Sarcoma CRIPAK 0.20 0.10 lasso 5 0.15 2.2e-09 -4.91 -5.4 5.4e-08 0.07 0.00 0.99 FALSE
75 The Cancer Genome Atlas Thyroid Carcinoma CRIPAK 0.38 0.22 enet 12 0.25 5.4e-24 -4.90 -6.3 2.1e-10 0.01 0.00 0.99 FALSE
76 The Cancer Genome Atlas Thyroid Carcinoma FAM53A 0.05 0.03 blup 56 0.04 1.8e-04 3.89 5.4 7.4e-08 0.79 0.01 0.95 FALSE
77 The Cancer Genome Atlas Thyroid Carcinoma TMEM129 0.20 0.21 lasso 5 0.24 3.5e-23 -3.75 5.8 6.0e-09 0.49 1.00 0.00 FALSE