Hub : Genes

SELM

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.2400	0.0850	3.0e-03	0.004	NA	0.063	NA	0.020	2.3e-01	NA	4.1e-03	NA	7.4e-02
2	GTEx	Pancreas	0.2890	0.0710	2.4e-08	0.232	NA	0.296	NA	0.259	3.6e-10	NA	5.2e-13	NA	2.4e-11
3	GTEx	Testis	0.1420	0.0620	3.4e-03	0.151	NA	0.095	NA	0.089	3.3e-07	NA	5.6e-05	NA	9.1e-05
4	METSIM	Adipose	0.0610	0.0245	1.1e-06	0.027	0.043	0.054	0.043	0.038	4.8e-05	4.5e-07	1.6e-08	4.7e-07	1.8e-06
5	TCGA	Bladder Urothelial Carcinoma	0.0560	0.0270	4.4e-04	0.011	0.022	0.009	NA	0.008	3.9e-02	5.2e-03	5.5e-02	NA	6.4e-02
6	TCGA	Kidney Renal Clear Cell Carcinoma	0.0289	0.0164	4.8e-03	0.038	0.007	0.010	NA	0.025	3.8e-05	4.9e-02	2.4e-02	NA	7.4e-04
7	TCGA	Thyroid Carcinoma	0.0440	0.0230	3.5e-03	0.003	0.008	0.008	NA	0.004	1.4e-01	4.8e-02	5.5e-02	NA	1.3e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	1.1	1.7	4.4	1.1	-1.0	-0.4	-2.1	1.2	1.1	-1.6
Bipolar Disorder or Schizophrenia	2.1	5.2	12.9	1.4	-1.9	-1.0	-3.2	2.3	1.1	-3.6
Depressed Affect (Nagel 2018)	0.6	1.3	3.1	0.9	0.8	1.2	0.1	-1.7	-1.8	-0.3
Depression (Nagel 2018)	0.6	0.9	3.9	1.5	-0.5	0.4	-0.1	-0.2	0.2	-2.0
Intelligence (Savage-Jansen 2018)	0.8	2.3	5.5	-0.1	1.5	1.3	1.2	-1.8	-1.5	2.3
Neuroticism (Nagel 2018)	1.7	3.9	7.2	1.0	2.4	2.4	1.4	-2.7	-2.1	1.0
Schizophrenia (2018)	1.7	3.5	10.3	1.0	-1.6	-1.0	-2.5	2.0	0.6	-3.2
Schizophrenia vs Biploar Disorder	0.1	0.2	0.8	-0.9	0.3	-0.3	0.4	-0.2	-0.1	-0.4
Worry (Nagel 2018)	1.1	2.3	4.7	0.8	1.9	2.1	0.9	-2.2	-1.2	0.8
Alzheimer’s Disease (in mother)	0.2	0.2	0.4	-0.6	0.3	0.0	-0.2	-0.6	0.4	0.5
Alzheimer’s Disease (in father)	3.5	3.8	8.3	-0.8	-1.9	-1.8	-1.2	2.6	2.9	-1.6
Alzheimer’s Disease (including proxy)	0.3	0.4	1.9	0.1	-0.1	0.1	-0.9	0.4	1.4	-0.6
Crohns Disease (2017)	0.5	1.1	3.3	-1.8	0.7	-0.3	-0.7	-0.0	-1.6	1.0
Irritable Bowel Disease (IBD)	0.6	1.4	2.9	-0.7	1.7	0.3	0.7	-0.8	-1.4	1.7
Ulcerative Colitis (UC)	0.8	1.6	2.7	0.9	1.6	0.6	1.6	-1.3	-0.5	1.6
Major Depression (MDD)	0.4	0.5	1.3	-1.0	0.3	0.2	0.9	-0.6	-1.1	0.1
Reaction Time	6.9	13.1	20.5	-2.4	-4.5	-3.3	-2.5	4.2	3.2	-4.5
Verbal and Numeric Reasoning (VNR)	1.4	3.4	11.9	0.1	1.5	0.8	1.7	-2.0	-1.4	3.4
Breast Cancer	0.2	0.6	1.3	0.1	-0.5	-0.5	-0.9	0.6	1.1	-0.9
Ovarian Cancer	0.2	0.2	0.4	-0.6	0.4	0.6	0.5	-0.3	-0.5	0.5
Prostate Cancer	0.4	0.6	1.3	-0.8	-0.9	0.0	-0.7	1.1	0.3	-1.0
Age at First Birth	0.3	0.4	2.3	-0.0	0.1	-0.4	-1.5	0.3	0.0	-0.1
Bipolar Disorder (2011)	0.4	0.3	1.4	0.5	-0.8	0.0	-1.2	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	2.2	3.0	5.7	-1.2	-1.7	-2.4	-0.7	2.3	1.7	-1.5
Coronary Artery Disease (CAD)	0.3	0.4	1.4	0.2	-0.6	0.0	-0.5	0.6	0.5	-1.2
Crohns Disease (2012)	1.2	1.9	4.4	-0.9	1.5	0.7	-0.1	-1.0	-2.1	2.1
Mean Putamen Volume	0.2	0.3	1.3	1.1	-0.1	-0.3	-0.2	-0.3	0.5	0.3
Fasting Glucose	0.8	0.9	2.9	-0.7	-0.4	-0.1	0.5	-0.6	1.7	1.5
HbA1C	0.5	0.6	2.0	-0.7	-0.0	-0.9	0.6	-0.3	-0.7	1.4
HDL Cholesterol	0.9	1.5	8.5	-1.2	0.5	-0.2	0.5	-0.2	0.2	2.9
LDL Cholesterol	0.4	0.7	2.4	-0.5	-0.8	-0.4	-0.8	-0.4	-0.8	-1.5
Lupus	1.7	2.6	3.7	-1.6	-1.4	-1.8	-1.5	1.9	1.7	-1.1
Neuroticism (2016)	0.9	1.3	2.6	-0.0	1.6	1.3	1.6	-1.0	-0.5	1.1
Primary Biliary Cirrhosis	1.5	2.1	5.0	-0.1	1.5	1.4	0.0	-1.6	-2.2	1.8
Rheumatoid Arthritis	0.4	0.6	1.2	0.1	-0.1	-0.2	-1.0	0.9	0.9	1.1
Schizophrenia (2014)	1.4	3.2	11.0	0.3	-1.4	-0.7	-2.1	1.9	0.9	-3.3
Triglycerides	0.6	1.0	1.8	-0.1	1.0	1.1	1.3	-0.9	-1.4	-0.1
Type 2 Diabetes (T2D) (2012)	1.6	1.8	3.7	-1.8	1.7	0.9	0.4	-0.9	-1.2	1.9
Ulcerative Colitis	0.7	1.0	3.1	0.4	0.4	-0.9	1.4	-0.3	0.9	1.8
Blood Eosinophil Count	5.9	45.7	74.3	-2.6	-6.1	-4.9	-8.6	8.6	7.5	-6.9
Blood Platelet Count	0.2	2.5	12.5	0.6	-0.5	-1.2	0.2	0.3	3.5	1.7
Blood Red Count	0.3	2.7	6.2	-1.2	-2.0	-2.5	0.7	-0.1	1.2	2.4
Blood White Count	1.8	13.7	27.5	2.3	3.6	2.9	3.3	-5.2	-2.8	4.8
Heel T-Score	1.1	8.4	12.4	-2.2	-3.2	-3.0	-3.2	3.5	0.9	-3.3
BMI	1.3	7.6	12.1	-0.0	-3.2	-3.0	-1.5	3.2	3.5	-3.0
Height	0.2	4.7	10.2	-2.9	-1.5	-1.6	0.2	2.7	3.2	1.2
Waist Hip Ratio (WHR)	3.3	14.6	27.4	0.0	3.7	3.8	4.5	-5.2	-3.8	3.4
Systolic Blood Pressure	1.8	9.2	15.2	0.8	3.4	3.4	2.5	-3.9	-3.1	3.0
Smoking Status	3.0	7.3	14.8	1.2	3.4	3.2	1.8	-2.8	-3.8	1.6
Allergy or Eczema	2.5	6.5	13.0	-2.8	-2.8	-3.6	-1.7	2.3	2.8	0.7
Cardiovascular Disease	0.2	0.7	1.8	0.3	0.9	1.0	0.8	-0.5	-1.4	-0.3
Hypothyroidism (self reported)	0.7	1.6	4.1	-1.0	-0.3	0.4	-2.0	1.2	-1.0	-1.8
Respiratory disease	1.1	2.4	5.2	-0.8	-2.3	-2.2	-1.0	1.4	1.5	-1.1
Type 2 Diabetes (T2D) (2018)	0.6	1.0	2.8	1.4	1.7	0.5	1.3	-0.3	0.1	0.8
Lung FEV1/FVC ratio	0.4	2.2	9.6	-0.1	0.2	1.0	-3.1	0.8	-0.7	-2.0
Lung FVC	1.1	5.7	12.9	-2.6	-1.7	-1.8	-3.6	2.9	0.4	-2.4
Neuroticism	1.3	3.2	7.1	1.0	2.2	1.9	1.2	-2.7	-1.7	1.2
Chronotype (morning person)	1.0	2.4	7.2	-0.7	-2.1	-1.7	0.5	1.3	0.3	-2.7
Hair Pigment	0.2	4.3	12.3	-1.0	1.8	1.5	1.9	-2.6	-0.9	3.5
Tanning	0.1	0.9	2.7	-0.7	-0.5	-0.3	-1.5	0.0	-1.6	0.7
Hand grip strength (left)	2.8	7.3	10.2	-2.2	-3.2	-2.8	-3.2	3.2	2.0	-2.0
Number of treatments/medications taken	0.4	0.7	1.7	-0.5	0.8	1.3	0.9	-0.2	-1.0	-0.5
Average weekly spirits intake	0.2	0.2	0.6	-0.3	-0.2	-0.1	-0.1	-0.8	-0.7	0.1
Sensitivity / hurt feelings	0.5	0.8	1.3	0.7	1.2	1.1	0.8	-1.1	-0.0	0.8
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.9	-0.5	-1.0	-0.5	-0.6	0.7	0.6	-0.6
Hearing difficulty/problems: Yes	1.0	1.5	5.2	0.1	1.5	0.1	1.4	-0.9	0.4	2.3
Relative age of first facial hair	0.2	0.4	0.7	-0.8	0.8	-0.2	0.8	-0.4	-0.3	0.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	1.1	0.3	0.3	0.3	1.1	0.7	0.3	0.4
Ever used hormone-replacement therapy (HRT)	1.6	2.0	3.6	0.9	1.8	1.9	1.6	-1.4	-1.0	0.9
Ever had hysterectomy (womb removed)	0.6	0.7	2.3	0.5	0.0	0.5	-1.1	0.9	0.1	-1.5
Systolic blood pressure, automated reading	0.9	2.5	4.7	-0.1	1.7	1.4	1.7	-2.2	-1.6	1.7
Eye problems/disorders: Diabetes related eye disease	2.2	2.4	5.7	0.4	2.4	1.9	1.2	-1.6	-1.4	1.2
Angina	0.1	0.2	0.8	-0.2	-0.2	0.2	0.1	0.4	-0.2	-0.9
Medication for hormone replacement therapy	0.8	0.9	2.5	-1.2	-0.7	-0.5	-1.6	0.8	-0.8	-0.3
Vitamin and mineral supplements	0.3	0.4	1.1	1.1	-0.6	0.1	-0.7	-0.3	0.7	-0.3
Supplements: Zinc	0.2	0.2	0.9	0.3	0.5	0.2	0.2	-0.2	-0.9	0.4
Medication: Co-codamol	0.9	1.0	3.6	0.8	1.0	0.9	1.9	-1.0	-0.1	0.4
Medication: Metformin	3.9	5.5	9.1	2.9	2.9	2.2	3.0	-2.0	-1.6	1.0
Diabetes (father)	1.0	1.2	2.6	-1.1	1.0	0.9	1.1	-1.2	-1.6	0.4
Diabetes (mother)	0.1	0.1	0.7	0.1	-0.3	0.1	-0.1	-0.0	0.2	-0.8
Severe depression (siblings)	2.7	3.0	6.5	-0.4	-1.4	-0.6	-1.4	2.5	2.0	-2.5
Pack years adult smoking proportion	1.0	1.5	5.3	2.3	1.5	1.4	0.7	-0.3	-0.5	0.5
Impedance of leg (right)	3.8	18.2	26.6	1.4	5.2	4.3	4.8	-5.0	-2.8	5.0
Leg fat-free mass (left)	1.1	6.0	10.6	-0.8	-2.9	-2.4	-2.0	3.3	2.7	-2.3
Trunk fat percentage	0.7	2.9	10.6	1.6	1.5	0.4	3.3	-1.5	0.5	1.5
Hand grip strength (right)	4.0	10.9	16.0	-2.5	-4.0	-3.2	-3.7	3.7	3.1	-2.6
Townsend deprivation index at recruitment	0.5	0.7	3.8	0.6	0.0	0.4	1.9	-0.4	0.5	-0.4
Current tobacco smoking	5.8	9.5	14.9	1.1	3.9	3.4	2.6	-3.3	-3.5	3.1
Average weekly fortified wine intake	0.4	0.4	1.2	0.3	0.5	0.5	0.5	-1.0	0.0	1.1
Maternal smoking around birth	0.9	1.4	3.5	0.3	1.2	1.4	0.7	-1.3	-1.9	0.7
Fed-up feelings	1.0	1.9	4.1	-0.6	-1.4	-0.9	-2.0	1.5	0.0	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	3.3	1.8	-0.4	0.2	-0.3	0.1	0.7	-1.1
Relative age voice broke	0.5	0.7	1.7	-0.5	-0.7	-1.3	-1.0	0.5	1.0	0.7
Taking other prescription medications	0.1	0.2	0.5	-0.5	0.7	0.6	-0.3	0.1	0.3	0.4
Age when periods started (menarche)	3.2	7.6	22.6	1.8	2.1	0.6	3.5	-3.2	-0.5	4.8
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	2.8	0.9	1.5	1.7	-0.1	-1.0	-0.9	0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.5	3.4	5.4	-2.2	-2.0	-2.2	-1.4	2.3	0.8	-1.5
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.2	1.3	1.0	1.5	0.8	-0.3	0.7	-0.3
Qualifications: CSEs or equivalent	1.7	2.3	4.2	1.9	-1.4	-0.6	-0.7	1.5	1.8	-2.1
Serious illness, injury or assault to yourself	2.1	2.6	11.1	0.0	1.0	0.9	1.2	-1.7	-3.3	0.9
High blood pressure	1.1	3.0	5.1	1.1	2.0	2.2	1.6	-2.3	-1.8	0.9
Hayfever, allergic rhinitis or eczema	1.9	4.1	8.1	-2.9	-2.0	-2.6	-1.1	1.7	2.3	0.7
Multivitamins +/- minerals	0.2	0.3	0.8	-0.4	0.9	0.7	0.3	-0.2	-0.6	0.4
Stomach or abdominal pain in last month	0.4	0.6	1.6	1.0	0.6	0.6	-0.0	-0.7	0.1	1.3
Supplements: Glucosamine	0.5	0.6	1.4	-1.2	-0.5	-0.9	-0.7	0.8	-0.6	0.6
Diverticular disease/diverticulitis (self-reported)	1.5	1.8	5.5	0.8	-1.3	-0.8	-2.3	1.2	1.6	-0.0
Medication: Atenolol	0.1	0.1	0.4	0.0	0.1	0.0	0.1	0.1	0.6	-0.3
Medication: Levothyroxine sodium	0.2	0.4	0.7	0.7	0.3	0.5	-0.9	0.1	-0.7	-0.6
Sitting height	1.3	9.6	17.9	-0.8	-3.7	-3.3	-2.0	4.2	4.2	-1.7
Chronic bronchitis/emphysema (father)	3.6	4.2	7.8	1.1	2.7	2.5	1.0	-2.0	-2.8	1.2
High blood pressure (mother)	1.2	1.7	4.0	0.2	1.2	1.0	0.8	-1.6	-1.4	2.0
Body mass index (BMI)	0.5	2.1	6.5	-0.2	-1.5	-1.4	-0.7	1.6	1.1	-2.6
Impedance of leg (left)	3.5	17.1	26.7	1.5	4.9	3.6	4.9	-4.9	-2.6	5.2
Leg predicted mass (left)	1.2	6.2	11.0	-0.9	-2.9	-2.5	-2.0	3.3	2.7	-2.3
Trunk fat mass	0.3	1.1	4.6	0.9	0.3	-0.4	2.2	-0.2	1.3	0.5
Waist circumference	0.2	0.8	4.2	0.3	0.4	0.2	2.0	-0.8	0.2	-0.3
Number of incorrect matches in round	0.2	0.4	1.0	0.3	0.4	0.8	1.0	-0.3	-0.2	-0.7
Past tobacco smoking	0.7	1.3	3.1	-0.7	-0.8	-1.3	-1.0	0.6	1.8	1.4
Alcohol usually taken with meals	2.1	3.4	9.3	0.4	-2.1	-0.8	-2.5	1.9	0.4	-3.0
Nervous feelings	0.7	1.4	3.5	0.8	1.6	1.3	-0.2	-1.0	0.0	1.9
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.3	-0.6	0.1	0.6	0.3	-0.1	-0.4	-0.4
Hearing difficulty/problems with background noise	1.5	2.4	5.0	-1.1	2.2	1.6	1.4	-1.3	-1.1	1.9
Hair/balding pattern: Pattern 2	3.9	5.0	7.4	0.9	2.7	2.5	2.1	-2.4	-2.7	1.8
Had menopause	0.6	0.8	2.7	0.2	1.3	1.7	0.4	-0.5	-0.4	0.7
Had other major operations	0.6	0.7	2.4	0.3	-1.1	0.2	-0.8	0.9	-0.3	-1.6
Forced vital capacity (FVC)	2.3	9.0	17.1	-2.8	-2.9	-2.7	-3.7	4.1	2.2	-1.9
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	4.0	-1.6	-1.9	-2.0	-1.2	1.6	0.7	-1.5
Ever unenthusiastic/disinterested for a whole week	0.4	0.4	1.9	1.4	0.1	-0.1	0.9	-0.2	-0.2	-0.5
Qualifications: None of the above	0.6	1.3	3.3	0.1	1.8	1.4	0.9	-1.0	-1.4	0.2
Financial difficulties in last 2 years	0.5	0.7	1.3	-0.5	-0.2	0.9	-1.2	0.8	-0.7	-1.0
Mouth/teeth dental problems	0.4	0.6	2.4	-0.9	0.2	-0.4	0.3	-0.8	-0.1	1.5
Heart attack	0.4	0.5	1.8	0.1	-0.5	-0.8	0.7	0.3	0.1	-1.3
Allergy	1.0	2.4	4.5	2.0	1.5	2.1	0.9	-1.0	-1.5	-1.3
Pain all over the body in last month	2.5	2.7	5.9	1.1	2.1	1.3	2.4	-1.4	-0.0	1.9
Diabetes (self-reported)	2.2	3.4	6.6	2.2	2.6	2.2	1.9	-1.6	-1.0	0.2
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	8.9	-3.0	-0.5	-0.3	-0.9	0.4	-0.3	-0.0
Medication: Ramipril	0.1	0.1	0.4	-0.6	0.1	0.0	0.1	0.0	0.1	-0.3
Medication: Simvastatin	0.1	0.2	0.6	-0.3	0.0	-0.7	0.7	0.5	0.2	-0.0
Fluid intelligence score	0.4	0.8	4.7	0.3	0.1	-0.0	0.6	-0.7	-0.1	2.2
Illnesses of siblings	1.8	2.5	5.5	0.3	-2.0	-0.6	-2.3	1.4	1.1	-2.1
Neuroticism score	0.2	0.4	0.9	0.4	1.0	0.8	-0.1	-0.9	-0.5	0.5
Weight	0.7	3.5	6.2	-0.5	-2.0	-2.0	-0.6	2.4	2.5	-2.0
Impedance of arm (right)	2.4	11.4	20.7	2.8	3.5	2.5	3.8	-4.2	-1.1	4.5
Arm fat percentage (right)	0.1	0.6	1.4	1.1	0.1	-0.3	1.2	-0.3	0.5	-1.0
Trunk fat-free mass	2.0	11.7	19.6	-2.3	-4.0	-3.2	-3.2	4.4	3.1	-3.2
Hip circumference	0.4	1.5	3.1	0.8	-1.1	-1.1	0.3	1.3	1.6	-1.8
Time employed in main current job	0.3	0.3	1.1	-0.5	0.5	0.1	1.0	-0.3	-0.7	0.1
Alcohol intake versus 10 years previously	1.3	1.9	4.0	-0.6	-1.2	-0.5	-1.8	2.0	0.8	-1.8
Father’s age at death	2.5	3.3	8.9	3.0	1.2	1.2	0.8	-2.1	-0.9	2.4
Worrier / anxious feelings	0.1	0.2	0.3	0.4	0.6	0.5	-0.3	0.1	-0.4	-0.6
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.8	-0.5	0.6	0.9	-0.1	-0.8	-0.9	0.7
Falls in the last year	0.6	0.7	1.6	1.3	-1.0	-1.2	-0.1	0.1	0.1	-1.1
Hair/balding pattern: Pattern 3	2.0	3.0	6.7	0.2	2.6	1.8	1.3	-1.6	-1.3	2.4
Number of live births	1.6	2.3	7.3	-0.7	-1.9	-1.4	-1.2	1.2	-0.4	-2.7
Forced expiratory volume in 1-second (FEV1)	3.0	10.3	21.4	-2.5	-3.0	-2.5	-4.6	4.2	2.0	-2.7
Pulse rate	0.2	0.3	1.7	-0.4	0.3	-0.2	1.3	-0.1	-0.5	0.2
Happiness	0.5	0.6	1.8	1.3	-0.5	-0.7	0.5	1.0	0.4	-0.6
Noisy workplace	1.4	1.8	5.7	-0.1	-0.4	0.7	-1.9	1.3	0.7	-2.4
Qualifications: A levels/AS levels or equivalent	0.2	0.5	1.9	1.4	-0.0	-0.1	-0.3	-1.0	-0.8	0.3
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	0.6	-0.3	0.5	0.7	0.3	-0.6	-0.3	0.7
Mouth/teeth dental problems: Dentures	0.3	0.6	1.6	1.2	0.1	0.6	0.4	0.1	-0.4	-1.3
Asthma	1.1	2.1	5.0	-0.6	-2.2	-2.2	-1.3	1.1	1.2	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.6	-0.5	-0.2	0.2	-0.7	-0.0	-0.8	-0.4
Medication: Cholesterol lowering	0.7	1.1	3.5	0.2	-0.5	-0.7	1.0	1.2	1.1	-1.9
Depression (self-reported)	0.7	0.8	2.6	-0.1	0.7	1.1	-0.5	-0.7	-0.8	1.6
Medication: Lansoprazole	0.8	0.9	4.3	1.0	0.7	-0.0	0.2	-0.3	0.6	2.1
Prospective memory result	1.6	2.0	5.9	-0.1	1.4	1.6	0.6	-1.6	-2.4	0.8
Lung cancer (father)	4.1	4.8	7.8	0.1	2.5	2.7	1.5	-2.8	-2.8	1.4
Illnesses of mother	1.5	1.9	3.4	-0.7	-1.4	-1.0	-0.7	1.6	1.8	-1.8
Forced expiratory volume in 1-second (FEV1), Best measure	2.5	7.9	21.2	-1.5	-2.6	-1.5	-4.6	3.5	2.1	-2.5
Pulse wave Arterial Stiffness index	2.0	2.3	3.9	0.0	2.0	1.4	1.8	-1.5	-1.0	2.0
Impedance of arm (left)	2.7	12.6	20.7	3.2	3.6	2.9	4.0	-4.3	-1.0	4.6
Arm fat mass (right)	0.3	1.2	2.5	0.4	-0.9	-1.1	0.3	1.1	1.5	-1.6
Trunk predicted mass	2.1	11.8	19.8	-2.3	-4.0	-3.2	-3.2	4.4	3.1	-3.3
Standing height	0.3	2.8	9.9	-0.6	-1.2	-1.5	0.3	2.1	3.1	1.1
Length of working week for main job	0.7	0.8	1.9	-0.1	-1.0	-0.7	-1.4	0.4	-1.0	-1.1
Exposure to tobacco smoke at home	0.2	0.3	1.2	1.1	-0.1	0.0	0.4	0.3	0.2	-0.6
Breastfed as a baby	0.4	0.5	2.5	-0.6	0.9	0.4	-0.2	0.1	-0.0	1.6
Tense / ‘highly strung’	0.5	0.9	2.9	-0.0	0.8	1.7	0.5	-1.2	-1.0	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.8	1.2	2.1	-0.2	1.2	1.3	1.2	-1.5	-1.2	0.5
Hair/balding pattern: Pattern 4	0.1	0.2	1.1	-0.1	-0.2	-1.1	-0.0	0.3	-0.1	0.7
Birth weight of first child	2.6	4.8	8.5	-0.3	-2.6	-1.6	-1.5	2.9	2.6	-2.6
Peak expiratory flow (PEF)	3.3	7.7	14.0	-2.0	-2.7	-2.4	-3.7	3.5	1.9	-2.7
Pulse wave reflection index	0.9	1.1	2.2	0.5	0.9	1.4	0.4	-1.5	-1.1	0.9
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.5	0.7	-0.0	0.3	0.6	-0.1	-0.3	-0.7
Loud music exposure frequency	0.5	0.6	2.4	0.1	-0.9	-0.2	-0.1	0.5	0.7	-1.5
Qualifications: O levels/GCSEs or equivalent	1.5	2.4	5.3	1.2	1.3	0.9	0.8	-2.3	-1.7	1.9
Mouth/teeth dental problems: Bleeding gums	1.3	1.7	3.5	-0.1	-1.7	-1.1	-1.9	1.6	1.2	-0.7
Blood clot in the leg (DVT)	0.7	1.0	2.4	-0.4	-0.9	-0.6	-1.6	1.5	0.5	-0.7
Medication: Paracetamol	0.3	0.6	2.4	0.4	0.4	0.9	0.1	0.1	-0.6	-1.6
Headache pain in last month	0.5	0.9	3.6	1.9	-0.7	0.2	-0.9	0.7	0.5	-0.7
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	2.0	0.6	-0.7	-0.2	-1.4	0.4	0.5	0.2
Glaucoma (self-reported)	7.5	8.9	13.7	1.0	3.4	3.0	3.4	-3.4	-3.7	2.0
Gout (self-reported)	0.3	0.3	0.7	-0.8	-0.2	-0.3	-0.7	-0.8	-0.7	-0.2
Hypothyroidism/myxoedema (self-reported)	0.7	1.4	4.7	-0.5	-0.6	0.4	-1.6	1.4	-0.2	-2.2
Medication: Amlodipine	0.5	0.6	1.5	-0.8	-0.2	0.4	-1.2	-0.4	-0.8	-1.2
Medication: Ventolin 100micrograms inhaler	0.2	0.3	1.4	0.1	-0.2	-0.3	0.5	-0.3	0.5	1.2
Birth weight	3.0	6.4	11.6	-0.6	-2.5	-2.6	-2.1	3.4	3.1	-2.4
Chronic bronchitis/emphysema (mother)	0.8	0.9	1.9	0.1	1.0	1.4	0.4	-1.1	-1.2	0.6
High blood pressure (siblings)	0.4	0.6	1.2	-1.1	0.9	0.6	0.2	-0.7	-0.6	0.8
Forced vital capacity (FVC), Best measure	2.0	7.4	13.7	-1.5	-2.7	-2.2	-3.6	3.7	2.9	-1.6
Body fat percentage	0.5	2.0	7.9	1.3	1.3	0.6	2.8	-1.4	0.2	0.5
Leg fat percentage (right)	0.6	2.0	5.6	0.5	1.8	1.3	2.4	-1.6	-0.8	0.2
Arm fat-free mass (right)	1.4	7.0	13.7	-1.7	-3.0	-2.4	-2.3	3.7	2.4	-2.7
Exposure to tobacco smoke outside home	0.6	0.8	2.5	1.3	-0.9	-0.4	0.4	0.4	0.4	-1.6
Comparative body size at age 10	1.3	3.5	5.9	-0.8	-2.3	-2.0	-1.8	2.4	0.2	-2.4
Number of full brothers	0.5	0.6	2.0	1.4	-0.6	-0.1	-0.5	0.2	0.1	-1.2
Worry too long after embarrassment	0.4	0.7	1.8	-1.4	1.0	0.5	0.9	-0.6	0.1	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	4.7	0.6	0.9	0.7	2.2	-1.1	0.2	0.4
Wheeze or whistling in the chest in last year	0.2	0.3	0.9	1.0	-0.2	-0.4	0.3	-0.4	-0.7	0.3
Number of children fathered	0.6	0.7	2.2	-0.3	1.2	1.5	-0.4	-0.2	-0.8	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	2.6	1.6	0.5	0.5	0.1	-0.4	-0.2	-0.2
Age at first live birth	0.8	1.5	2.3	-1.0	-1.1	-1.5	-1.5	1.3	1.3	0.6
Pulse wave peak to peak time	2.5	3.0	5.0	-0.2	-2.2	-1.7	-1.9	1.8	1.2	-2.1
Health satisfaction	0.6	0.8	3.6	-0.5	-0.8	0.3	-0.1	0.8	-0.2	-1.9
Shortness of breath walking on level ground	0.5	0.5	1.3	-0.4	1.0	0.6	1.2	-0.5	-0.6	0.5
Qualifications: College or University degree	0.8	2.6	5.7	-0.2	-2.4	-1.8	-1.5	1.4	1.5	-1.7
Eye problems/disorders: None of the above	4.3	5.0	10.1	-0.7	-2.6	-1.8	-2.6	2.0	3.2	-1.9
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.5	-0.2	0.1	0.6	-0.3	0.1	-1.6	-1.0
Emphysema/chronic bronchitis	2.2	2.5	3.2	1.1	1.8	1.5	1.8	-1.7	-1.5	1.6
Medication for pain relief, constipation, heartburn	0.4	0.7	2.2	0.6	-0.1	-0.6	0.7	-1.1	0.4	1.5
Neck or shoulder pain in last month	0.2	0.2	1.0	-0.0	-1.0	-0.2	-0.6	0.2	-0.3	0.1
Medication: Blood pressure	1.3	2.2	3.9	-0.5	1.7	1.4	1.9	-1.7	-2.0	0.6
Angina (self-reported)	0.1	0.1	0.6	-0.0	-0.2	0.3	0.2	0.2	-0.2	-0.8
Migraine (self-reported)	0.1	0.1	0.2	-0.2	-0.2	0.5	-0.3	-0.4	-0.2	-0.4
Medication: Ibuprofen	0.1	0.2	0.7	-0.3	-0.3	0.0	-0.4	0.0	-0.9	-0.1
Medication: Allopurinol	0.5	0.6	1.9	-0.6	0.4	0.3	1.0	-1.4	-0.9	-0.1
Medication: Omeprazole	0.2	0.3	0.7	-0.6	-0.2	-0.0	-0.2	0.8	0.8	0.4
Medication: Seretide 50 evohaler	0.9	1.1	4.5	-2.1	-0.7	-1.1	-0.3	-0.4	-0.8	0.6
Mean time to correctly identify matches	6.0	11.4	17.0	-2.5	-4.1	-3.2	-2.5	4.1	3.0	-3.8
Heart disease (mother)	0.7	0.8	1.7	-0.1	-0.7	-1.3	-0.9	1.3	0.8	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.3	-0.1	-0.3	0.1	-0.4	-0.1	-0.2	-0.5
Whole body fat mass	0.2	0.6	3.1	0.6	0.2	-0.4	1.8	-0.0	1.0	0.0
Leg fat mass (right)	0.1	0.3	1.3	0.2	0.2	-0.2	1.2	0.2	0.6	-0.6
Arm predicted mass (right)	1.2	6.1	11.8	-1.5	-2.9	-2.3	-2.0	3.4	2.4	-2.3
Pulse rate, automated reading	1.1	3.7	5.9	0.1	2.4	1.3	2.2	-2.3	-1.6	2.4
Alcohol intake frequency.	0.3	0.7	3.4	0.5	-0.3	-0.1	-0.6	1.0	0.1	-1.8
Comparative height size at age 10	0.3	1.8	4.3	-1.3	-1.2	-1.0	-0.8	2.1	1.8	-0.1
Number of full sisters	0.9	1.1	2.7	1.6	0.0	0.6	-1.6	-0.0	-0.5	-1.5
Suffer from ‘nerves’	1.4	2.1	4.2	0.8	1.7	1.3	1.1	-2.0	-0.6	2.0
Overall health rating	0.3	0.7	1.5	0.0	1.1	1.2	1.0	-0.5	-0.7	0.1
Chest pain or discomfort	0.4	0.6	1.7	1.3	-0.1	0.8	-0.2	0.0	-0.8	-1.0
Had major operations	0.4	0.4	1.3	-0.7	-0.4	-0.0	0.6	0.5	0.6	-1.2
Age at last live birth	0.8	1.2	3.3	0.0	-1.1	-1.5	-1.8	1.1	0.7	0.1
Family relationship satisfaction	0.2	0.2	1.1	1.0	-0.1	0.0	0.2	0.2	0.1	-0.4
Leg pain on walking	0.7	0.8	2.1	0.9	0.9	0.8	1.4	-1.0	-0.8	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.4	0.9	0.9	0.6	0.4	-0.1	-0.1	1.2
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.8	-1.7	0.9	0.8	-0.5	0.0	-1.3	-0.1
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.9	0.9	-0.0	-0.4	0.9	-0.0	0.9	-0.2
Medication: Aspirin	0.1	0.1	0.4	0.4	0.6	0.3	0.4	0.1	-0.1	0.2
Supplements: Vitamin C	0.9	1.1	2.4	-0.2	-1.5	-1.2	0.3	1.5	0.7	-0.9
Knee pain experienced in last month	1.6	2.4	5.2	0.3	1.8	2.3	1.2	-1.9	-1.7	0.8
Hypertension (Self-reported)	1.3	3.7	6.3	1.3	2.2	2.5	1.5	-2.4	-2.2	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.4	-0.2	0.4	0.3	-1.5	0.2	0.0	1.4
Illnesses of father: Heart disease	1.5	2.1	3.3	-0.8	-1.8	-1.3	-1.8	1.5	1.4	-1.3
Illnesses of siblings: Diabetes	1.1	1.4	2.9	-1.7	1.2	-0.1	1.4	-0.6	-0.6	1.6
Smoking status: Previous	0.4	0.6	1.9	0.7	0.2	0.8	0.2	-0.2	-1.1	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.6	4.3	-1.7	-1.8	-1.8	-1.2	2.1	1.7	-0.5
Whole body fat-free mass	1.7	9.7	17.2	-1.7	-3.6	-3.0	-2.8	4.1	3.0	-3.0
Leg fat-free mass (right)	1.4	7.3	12.3	-0.8	-3.3	-2.9	-2.2	3.5	2.8	-2.4
Arm fat percentage (left)	0.2	0.7	1.8	1.3	0.3	0.0	1.3	-0.5	0.6	-0.9
Average weekly red wine intake	0.4	0.6	2.9	0.5	0.4	0.8	-0.2	-0.6	-1.7	0.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.5	-0.1	-0.2	-0.2	-0.1	-0.1	0.7	0.1
Mood swings	0.4	0.7	3.7	1.9	-0.2	-0.2	-0.4	0.3	1.0	-0.1
Loneliness, isolation	0.3	0.4	1.3	0.3	0.6	0.5	-0.8	-0.4	-1.1	0.4
Long-standing illness, disability or infirmity	0.6	0.9	1.6	-0.9	1.2	0.7	1.2	-0.6	-0.1	1.3
Ever had bowel cancer screening	1.1	1.3	3.2	0.6	1.2	0.6	1.8	-1.0	0.5	1.6
Diabetes diagnosed by doctor	1.9	3.1	6.5	1.9	2.6	2.0	2.0	-1.4	-0.9	0.6
Ever had stillbirth, spontaneous miscarriage or termination	1.3	1.4	2.3	0.6	-1.5	-1.3	-0.9	1.2	1.0	-1.4
Friendships satisfaction	1.3	1.7	3.8	0.7	-1.3	-0.4	-0.6	1.4	1.8	-1.9
Qualifications: nursing, teaching	0.4	0.6	1.9	0.3	-0.9	-1.4	-1.2	0.2	0.4	0.3
Commuting to job workplace: Walk	0.9	1.0	3.5	0.3	0.6	-0.1	1.9	-1.0	-0.8	1.2
Eye problems/disorders: Cataract	2.4	2.7	4.4	1.5	1.7	1.8	1.6	-1.6	-2.1	1.1
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.1	-0.2	0.8	0.1	1.1	-0.3	-0.8	-0.1
Medication for cholesterol	0.3	0.5	1.0	0.8	0.8	0.3	0.9	-0.1	1.0	0.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.3	0.1	-0.1	0.4	-0.0	-0.4	-0.6	0.0
Back pain experienced in last month	0.3	0.5	1.4	-1.2	0.3	0.8	0.4	-0.0	-1.0	0.4
Mineral and other dietary supplements	0.4	0.5	1.0	0.4	-0.6	-0.9	0.4	0.3	1.0	0.9
Breast cancer (self-reported)	0.4	0.4	1.1	0.6	0.2	0.3	0.7	-1.1	-0.6	0.7
Asthma (self-reported)	1.0	2.1	4.8	-0.7	-2.2	-2.2	-1.3	1.3	1.1	-0.2
Osteoporosis (self-reported)	1.0	1.3	4.9	0.1	0.8	0.5	2.2	-1.4	-1.0	0.6
Osteoarthritis (self-reported)	0.2	0.2	0.4	0.2	0.6	0.2	0.5	-0.4	-0.7	0.5
Medication: Aspirin	0.1	0.2	0.7	0.3	0.6	0.3	0.8	0.1	0.1	0.2
Medication: Gliclazide	1.2	1.4	3.6	1.9	1.3	0.7	1.3	-1.0	-0.6	1.0
Illnesses of father: None of the above (group 1)	0.3	0.3	1.9	1.4	-0.0	0.2	0.3	-0.2	0.3	-0.2
Smoking status: Current	5.0	8.0	13.2	1.1	3.6	3.0	2.5	-2.9	-3.1	2.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	5.5	-0.8	-1.1	-0.3	-2.4	1.4	0.9	-1.3
Whole body water mass	1.8	10.0	17.5	-1.7	-3.7	-3.1	-2.9	4.2	3.0	-3.1
Leg predicted mass (right)	1.3	7.2	12.1	-0.8	-3.3	-2.9	-2.2	3.5	2.8	-2.4
Arm fat mass (left)	0.3	1.1	2.2	0.2	-0.9	-1.1	0.3	1.2	1.5	-1.5
Number of self-reported non-cancer illnesses	0.2	0.3	1.3	-1.1	0.2	0.7	-0.2	0.6	0.0	-0.5
Average weekly champagne plus white wine intake	0.5	0.7	1.2	-0.7	-1.1	-0.8	-1.1	0.8	0.2	-0.6
Miserableness	0.3	0.6	1.7	0.9	-0.7	-0.2	-1.0	-0.1	-0.0	-1.3
Guilty feelings	0.2	0.3	1.2	0.2	0.0	-0.5	0.2	0.6	1.1	-0.1
Wears glasses or contact lenses	1.1	1.3	3.9	0.6	2.0	1.2	0.9	-0.9	-0.9	0.9
Ever taken oral contraceptive pill	0.3	0.3	0.6	-0.5	-0.7	-0.1	-0.8	0.6	0.1	-0.5
Hearing aid user	0.3	0.3	1.1	-0.6	1.0	-0.0	0.0	0.2	-0.8	0.6
Mother’s age at death	2.1	2.7	4.4	0.8	-2.0	-2.1	-1.5	1.7	1.8	-1.0
Financial situation satisfaction	1.5	1.8	5.5	2.3	0.9	0.9	2.1	-0.8	-0.5	0.5
Tinnitus: Yes, now most or all of the time	3.2	3.8	7.5	-1.9	-2.7	-2.1	-1.0	1.7	2.0	-1.8
Commuting to job workplace: Public transport	0.9	1.1	4.3	1.0	-0.3	-0.7	2.1	-0.1	1.1	0.6
Eye problems/disorders: Glaucoma	2.4	2.9	6.9	0.4	1.6	1.8	1.7	-2.1	-2.6	0.2
Medication: Blood pressure	0.2	0.4	0.9	0.2	0.1	0.8	-0.9	-0.5	-0.3	-0.7
Pain type(s) experienced in last month: Hip pain	0.5	0.6	1.1	0.8	1.1	1.0	0.6	-0.1	-0.8	0.7
Supplements: Fish oil (including cod liver oil)	2.2	2.9	6.0	0.5	2.1	2.4	0.6	-1.8	-2.3	-0.8
High cholesterol (Self-reported)	0.3	0.5	1.3	-0.5	-0.4	-0.9	0.5	1.2	0.3	-0.6
Medication: Bendroflumethiazide	0.6	0.9	1.3	0.9	1.0	0.8	0.9	-1.1	-1.1	0.7
Medication: Paracetamol	0.4	0.7	1.6	0.8	0.6	1.3	0.4	-0.2	-0.6	-1.2
Medication: Lisinopril	0.3	0.4	0.9	-0.5	0.5	-0.0	0.8	-0.9	-0.7	0.7
Medication: Atorvastatin	0.5	0.6	3.5	0.4	-0.5	0.4	0.6	0.2	0.3	-1.9
Illnesses of father: High blood pressure	0.3	0.4	1.0	0.9	-0.7	-0.2	0.0	0.1	-0.2	-1.0
Alcohol drinker status: Never	0.4	0.4	1.5	1.2	-0.5	-0.8	0.2	0.6	0.4	-0.0
Ever smoked	0.4	0.8	2.1	0.6	0.5	0.8	0.6	-0.3	-1.4	-1.3
Basal metabolic rate	1.6	8.6	15.2	-1.5	-3.4	-2.9	-2.3	3.9	3.0	-2.9
Leg fat percentage (left)	0.5	2.0	6.1	0.6	1.7	1.0	2.5	-1.6	-0.8	0.4
Arm fat-free mass (left)	1.9	9.5	17.6	-2.3	-3.4	-3.0	-2.5	4.2	2.9	-2.9
Number of operations (self-reported)	0.4	0.6	1.8	-0.5	0.0	1.2	-0.1	-0.0	-0.6	-1.4
Average weekly beer plus cider intake	3.1	4.5	6.6	1.7	2.4	2.0	2.0	-2.4	-1.6	2.6
Irritability	1.2	2.1	4.9	-0.5	1.9	2.2	0.7	-1.4	-1.6	0.8
Risk taking	0.2	0.3	0.8	0.9	-0.5	-0.4	0.5	-0.1	-0.6	0.4
Ever had prostate specific antigen (PSA) test	0.6	0.6	1.4	-0.9	1.0	0.7	0.1	-0.8	-0.3	1.2
Fractured/broken bones in last 5 years	0.7	0.9	2.0	0.3	0.7	1.4	0.6	-1.0	-1.3	-0.4
Age started oral contraceptive pill	0.3	0.4	1.4	1.2	0.6	0.7	0.3	-0.3	0.1	-0.4
Diastolic blood pressure, automated reading	0.6	1.8	3.9	0.9	1.1	1.2	1.1	-2.0	-1.6	0.9
Ever depressed for a whole week	0.1	0.1	0.2	-0.4	0.1	-0.4	0.2	0.4	0.2	0.1
Unable to work because of sickness or disability	0.2	0.2	0.7	-0.8	0.6	0.6	0.2	-0.3	-0.4	-0.2
Commuting to job workplace: Cycle	0.8	0.9	2.8	0.6	-1.7	-1.0	0.2	0.5	0.6	-1.2
Myopia	1.0	1.5	6.0	-1.9	0.3	-0.1	-0.5	-0.2	0.1	2.5
Vascular/heart problems diagnosed by doctor	1.1	3.1	5.1	-1.0	-2.0	-2.1	-1.6	2.3	1.9	-1.1
Cholesterol lowering medication	0.1	0.2	0.4	-0.4	-0.7	-0.4	0.2	0.3	-0.2	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.6	-0.5	0.0	0.1	0.0	0.3	0.2	0.8
Pain experienced in last month	0.2	0.4	1.5	-0.4	-0.7	-1.2	-0.3	0.1	0.3	-0.4
Supplements: Calcium	0.7	0.7	1.4	0.5	1.2	1.2	0.6	-0.4	-0.8	0.9
Basal cell carcinoma (self-reported)	0.4	0.5	1.0	-0.9	0.1	-0.4	1.0	0.9	0.7	-0.7
Heart attack/myocardial infarction (self-reported)	0.5	0.6	2.2	-0.2	-0.7	-1.1	0.5	0.6	0.3	-1.5
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	3.3	-0.8	-1.1	-0.9	-1.8	1.7	0.6	-0.7
Heart disease (siblings)	1.1	1.3	3.9	2.0	1.2	0.9	0.4	-0.5	-0.8	1.4
Alcohol drinker status: Previous	1.5	1.7	5.9	0.6	1.3	0.9	2.4	-1.6	-0.6	-0.3
Pack years of smoking	1.1	1.7	5.2	2.3	1.5	1.4	1.1	-0.5	-0.4	0.8
Impedance of whole body	3.3	16.6	28.1	2.7	4.5	3.3	4.8	-4.8	-1.9	5.3
Leg fat mass (left)	0.1	0.3	1.4	0.1	0.2	-0.3	1.2	0.2	0.5	-0.5
Arm predicted mass (left)	1.7	8.4	16.1	-1.9	-3.2	-2.8	-2.3	4.0	2.7	-2.9