Best TWAS P=1.42e-19 · Best GWAS P=3.05e-19 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | LOC645513 | 0.27 | 0.50 | enet | 50 | 0.51 | 2.1e-72 | -7.95 | 8.1 | 4.0e-16 | -0.89 | 0.98 | 0.02 | TRUE |
2 | CommonMind | Brain Pre-frontal Cortex | PDE5A | 0.05 | 0.04 | lasso | 2 | 0.03 | 8.1e-05 | -8.13 | 8.3 | 8.2e-17 | -0.89 | 0.19 | 0.81 | FALSE |
3 | CommonMind | Brain Pre-frontal Cortex | USP53 | 0.16 | 0.13 | lasso | 11 | 0.20 | 3.5e-23 | 5.96 | 8.9 | 5.4e-19 | -0.69 | 0.97 | 0.03 | FALSE |
4 | GTEx | Adipose Subcutaneous | C4orf3 | 0.11 | 0.01 | lasso | 9 | 0.03 | 3.4e-03 | -4.35 | -5.2 | 2.5e-07 | 0.64 | 0.15 | 0.34 | FALSE |
5 | GTEx | Adipose Subcutaneous | RP11-33B1.1 | 0.23 | 0.10 | lasso | 12 | 0.18 | 4.7e-15 | 5.35 | 8.5 | 2.2e-17 | -0.72 | 0.15 | 0.85 | FALSE |
6 | GTEx | Adipose Visceral Omentum | RP11-33B1.1 | 0.23 | 0.10 | lasso | 7 | 0.17 | 5.2e-09 | -7.45 | 8.3 | 9.9e-17 | -0.72 | 0.24 | 0.75 | FALSE |
7 | GTEx | Adrenal Gland | RP11-33B1.1 | 0.13 | 0.07 | enet | 25 | 0.09 | 5.5e-04 | -7.99 | 7.9 | 2.3e-15 | -0.78 | 0.18 | 0.75 | FALSE |
8 | GTEx | Adrenal Gland | RP11-33B1.4 | 0.11 | 0.10 | enet | 20 | 0.16 | 3.2e-06 | -7.90 | 7.0 | 3.6e-12 | -0.81 | 0.04 | 0.95 | FALSE |
9 | GTEx | Artery Aorta | RP11-33B1.1 | 0.12 | 0.10 | lasso | 8 | 0.13 | 2.0e-07 | -7.45 | 8.4 | 4.8e-17 | -0.88 | 0.89 | 0.10 | FALSE |
10 | GTEx | Artery Aorta | RP11-33B1.4 | 0.11 | 0.04 | enet | 15 | 0.04 | 1.7e-03 | -7.90 | -6.4 | 1.8e-10 | 0.82 | 0.33 | 0.61 | FALSE |
11 | GTEx | Artery Coronary | RP11-33B1.1 | 0.21 | 0.16 | lasso | 10 | 0.22 | 7.4e-08 | -7.96 | 7.7 | 1.3e-14 | -0.75 | 0.60 | 0.39 | FALSE |
12 | GTEx | Artery Coronary | RP11-33B1.4 | 0.10 | 0.02 | lasso | 2 | 0.01 | 1.5e-01 | -7.49 | -7.6 | 3.1e-14 | 0.79 | 0.14 | 0.45 | FALSE |
13 | GTEx | Artery Tibial | C4orf3 | 0.04 | 0.00 | enet | 7 | 0.03 | 3.2e-03 | -4.35 | -7.0 | 3.5e-12 | 0.65 | 0.06 | 0.79 | FALSE |
14 | GTEx | Artery Tibial | RP11-33B1.1 | 0.22 | 0.17 | lasso | 7 | 0.16 | 1.4e-12 | -7.45 | 8.2 | 3.2e-16 | -0.83 | 0.95 | 0.05 | FALSE |
15 | GTEx | Artery Tibial | RP11-33B1.4 | 0.14 | 0.10 | lasso | 7 | 0.06 | 8.5e-06 | -8.13 | -7.2 | 4.9e-13 | 0.75 | 0.61 | 0.37 | FALSE |
16 | GTEx | Brain Caudate basal ganglia | PDE5A | 0.13 | 0.02 | enet | 12 | 0.06 | 6.4e-03 | -8.07 | 8.6 | 9.9e-18 | -0.79 | 0.09 | 0.70 | FALSE |
17 | GTEx | Brain Caudate basal ganglia | RP11-33B1.1 | 0.27 | 0.34 | lasso | 2 | 0.29 | 5.9e-09 | -8.13 | 8.3 | 1.4e-16 | -0.85 | 0.24 | 0.76 | FALSE |
18 | GTEx | Brain Caudate basal ganglia | RP11-33B1.4 | 0.12 | 0.16 | lasso | 4 | 0.15 | 5.7e-05 | -8.41 | 8.8 | 1.1e-18 | -0.97 | 0.05 | 0.91 | FALSE |
19 | GTEx | Brain Cerebellar Hemisphere | RP11-33B1.1 | 0.35 | 0.34 | lasso | 8 | 0.33 | 2.5e-09 | -8.13 | 8.5 | 2.7e-17 | -0.82 | 0.22 | 0.74 | FALSE |
20 | GTEx | Brain Cerebellar Hemisphere | RP11-33B1.4 | 0.13 | 0.05 | lasso | 4 | 0.01 | 1.6e-01 | -7.85 | -8.2 | 3.1e-16 | 0.90 | 0.10 | 0.58 | FALSE |
21 | GTEx | Brain Cerebellum | RP11-33B1.1 | 0.31 | 0.30 | lasso | 11 | 0.32 | 2.9e-10 | -8.13 | 8.2 | 2.7e-16 | -0.78 | 0.75 | 0.24 | FALSE |
22 | GTEx | Brain Cerebellum | RP11-33B1.4 | 0.14 | -0.01 | enet | 18 | -0.01 | 7.4e-01 | -7.83 | -8.5 | 2.6e-17 | 0.82 | 0.12 | 0.29 | FALSE |
23 | GTEx | Brain Cortex | RP11-33B1.1 | 0.42 | 0.24 | enet | 23 | 0.28 | 1.7e-08 | -8.13 | 6.8 | 8.5e-12 | -0.64 | 0.71 | 0.23 | FALSE |
24 | GTEx | Brain Frontal Cortex BA9 | RP11-33B1.1 | 0.36 | 0.28 | lasso | 8 | 0.25 | 2.2e-07 | -7.45 | 7.7 | 9.4e-15 | -0.87 | 0.68 | 0.28 | FALSE |
25 | GTEx | Brain Hippocampus | RP11-33B1.1 | 0.18 | 0.02 | enet | 20 | 0.05 | 2.2e-02 | -8.07 | 7.4 | 1.6e-13 | -0.74 | 0.19 | 0.39 | FALSE |
26 | GTEx | Brain Hypothalamus | RP11-33B1.1 | 0.40 | 0.24 | lasso | 6 | 0.23 | 4.5e-06 | -8.13 | 8.0 | 1.4e-15 | -0.74 | 0.26 | 0.56 | FALSE |
27 | GTEx | Brain Nucleus accumbens basal ganglia | MYOZ2 | 0.35 | -0.01 | enet | 34 | 0.07 | 5.8e-03 | 6.24 | -5.6 | 1.6e-08 | 0.41 | 0.07 | 0.43 | FALSE |
28 | GTEx | Brain Nucleus accumbens basal ganglia | RP11-33B1.1 | 0.42 | 0.36 | lasso | 11 | 0.33 | 9.5e-10 | -7.99 | 8.2 | 2.5e-16 | -0.90 | 0.18 | 0.82 | FALSE |
29 | GTEx | Brain Putamen basal ganglia | RP11-33B1.1 | 0.32 | 0.16 | lasso | 7 | 0.16 | 9.9e-05 | -8.13 | 8.4 | 3.6e-17 | -0.75 | 0.21 | 0.41 | FALSE |
30 | GTEx | Breast Mammary Tissue | RP11-33B1.1 | 0.19 | 0.08 | lasso | 4 | 0.15 | 3.7e-08 | 6.92 | 8.5 | 1.3e-17 | -0.68 | 0.67 | 0.33 | FALSE |
31 | GTEx | Breast Mammary Tissue (Female) | RP11-33B1.1 | 0.31 | 0.29 | enet | 10 | 0.24 | 9.1e-08 | 5.94 | 7.0 | 2.2e-12 | -0.44 | 0.83 | 0.09 | FALSE |
32 | GTEx | Cells EBV-transformed lymphocytes | PDE5A | 0.25 | 0.20 | lasso | 27 | 0.20 | 5.1e-07 | -7.96 | 8.7 | 3.0e-18 | -0.95 | 0.08 | 0.91 | FALSE |
33 | GTEx | Cells EBV-transformed lymphocytes | USP53 | 0.13 | 0.01 | lasso | 5 | 0.02 | 8.8e-02 | -7.49 | 7.3 | 3.0e-13 | -0.84 | 0.04 | 0.69 | TRUE |
34 | GTEx | Cells EBV-transformed lymphocytes | RP11-33B1.1 | 0.33 | 0.46 | lasso | 8 | 0.44 | 4.3e-16 | -7.96 | 8.0 | 1.4e-15 | -0.91 | 0.71 | 0.29 | FALSE |
35 | GTEx | Cells Transformed fibroblasts | RP11-33B1.1 | 0.23 | 0.44 | lasso | 11 | 0.45 | 1.8e-37 | -7.99 | 8.2 | 1.7e-16 | -0.91 | 0.98 | 0.02 | FALSE |
36 | GTEx | Colon Sigmoid | RP11-33B1.1 | 0.25 | 0.14 | lasso | 3 | 0.16 | 2.3e-06 | -8.07 | 8.2 | 3.0e-16 | -0.79 | 0.50 | 0.37 | FALSE |
37 | GTEx | Colon Sigmoid | RP11-33B1.4 | 0.10 | 0.03 | lasso | 3 | 0.04 | 1.1e-02 | -7.45 | -7.7 | 1.3e-14 | 0.70 | 0.20 | 0.42 | FALSE |
38 | GTEx | Colon Transverse | RP11-33B1.1 | 0.25 | 0.31 | lasso | 10 | 0.39 | 7.1e-20 | -7.99 | 8.0 | 1.2e-15 | -0.77 | 0.96 | 0.04 | FALSE |
39 | GTEx | Esophagus Mucosa | RP11-33B1.1 | 0.25 | 0.29 | lasso | 12 | 0.36 | 3.3e-25 | -7.96 | 8.4 | 5.4e-17 | -0.78 | 0.96 | 0.04 | FALSE |
40 | GTEx | Esophagus Muscularis | RP11-33B1.1 | 0.10 | 0.14 | lasso | 3 | 0.12 | 1.4e-07 | -8.13 | 8.2 | 1.8e-16 | -0.89 | 0.59 | 0.41 | FALSE |
41 | GTEx | Esophagus Muscularis | RP11-33B1.4 | 0.16 | 0.00 | enet | 28 | 0.00 | 2.8e-01 | 0.46 | -5.7 | 1.6e-08 | 0.54 | 0.20 | 0.23 | FALSE |
42 | GTEx | Heart Atrial Appendage | MYOZ2 | 0.17 | 0.01 | enet | 16 | 0.02 | 5.7e-02 | -8.74 | -7.7 | 1.2e-14 | 0.71 | 0.06 | 0.73 | FALSE |
43 | GTEx | Heart Atrial Appendage | RP11-33B1.1 | 0.15 | 0.08 | lasso | 3 | 0.10 | 4.0e-05 | -7.93 | 8.3 | 1.1e-16 | -0.76 | 0.66 | 0.29 | FALSE |
44 | GTEx | Heart Atrial Appendage | RP11-33B1.4 | 0.12 | 0.10 | lasso | 4 | 0.05 | 2.0e-03 | -8.13 | -8.6 | 6.3e-18 | 0.85 | 0.28 | 0.37 | FALSE |
45 | GTEx | Liver | RP11-33B1.1 | 0.18 | 0.12 | enet | 31 | 0.17 | 1.6e-05 | -7.95 | 7.9 | 3.0e-15 | -0.81 | 0.23 | 0.74 | FALSE |
46 | GTEx | Liver | RP11-33B1.4 | 0.18 | 0.14 | lasso | 6 | 0.12 | 3.2e-04 | -8.97 | 9.1 | 1.4e-19 | -0.99 | 0.04 | 0.95 | TRUE |
47 | GTEx | Lung | RP11-33B1.1 | 0.16 | 0.12 | lasso | 9 | 0.22 | 6.0e-17 | 4.07 | 7.7 | 1.3e-14 | -0.65 | 0.98 | 0.02 | FALSE |
48 | GTEx | Lung | RP11-33B1.4 | 0.10 | 0.10 | lasso | 5 | 0.09 | 4.2e-07 | -7.90 | -7.7 | 1.0e-14 | 0.90 | 0.75 | 0.24 | FALSE |
49 | GTEx | Muscle Skeletal | RP11-33B1.1 | 0.04 | 0.03 | lasso | 3 | 0.02 | 8.1e-03 | -7.95 | 8.1 | 6.5e-16 | -0.86 | 0.33 | 0.62 | FALSE |
50 | GTEx | Nerve Tibial | RP11-33B1.1 | 0.42 | 0.25 | enet | 32 | 0.35 | 1.1e-25 | -7.45 | 7.4 | 1.3e-13 | -0.69 | 0.97 | 0.03 | FALSE |
51 | GTEx | Ovary | RP11-33B1.1 | 0.26 | 0.07 | enet | 33 | 0.16 | 1.2e-04 | 6.01 | 8.6 | 6.3e-18 | -0.63 | 0.14 | 0.51 | FALSE |
52 | GTEx | Ovary | RP11-33B1.4 | 0.13 | 0.07 | lasso | 3 | 0.02 | 1.2e-01 | -7.49 | -8.2 | 1.7e-16 | 0.86 | 0.08 | 0.34 | FALSE |
53 | GTEx | Pancreas | RP11-33B1.1 | 0.13 | 0.18 | lasso | 5 | 0.18 | 4.7e-08 | -7.99 | 8.9 | 3.8e-19 | -0.88 | 0.48 | 0.52 | FALSE |
54 | GTEx | Pancreas | RP11-33B1.4 | 0.20 | 0.05 | lasso | 16 | 0.05 | 3.8e-03 | -8.41 | 8.4 | 2.9e-17 | -0.96 | 0.02 | 0.97 | FALSE |
55 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-33B1.1 | 0.16 | 0.12 | enet | 9 | 0.13 | 1.0e-07 | -7.45 | 7.4 | 1.7e-13 | -0.73 | 0.72 | 0.26 | FALSE |
56 | GTEx | Skin Sun Exposed Lower leg | USP53 | 0.07 | 0.00 | enet | 26 | 0.00 | 2.6e-01 | -8.93 | -5.3 | 1.1e-07 | 0.63 | 0.04 | 0.73 | FALSE |
57 | GTEx | Skin Sun Exposed Lower leg | RP11-33B1.1 | 0.12 | 0.10 | lasso | 3 | 0.09 | 6.6e-08 | 4.07 | 6.4 | 1.5e-10 | -0.37 | 1.00 | 0.00 | FALSE |
58 | GTEx | Small Intestine Terminal Ileum | RP11-33B1.1 | 0.15 | 0.10 | lasso | 19 | 0.09 | 5.4e-03 | -7.90 | 8.2 | 1.9e-16 | -0.88 | 0.11 | 0.56 | FALSE |
59 | GTEx | Spleen | RP11-33B1.1 | 0.22 | 0.03 | enet | 17 | 0.02 | 7.7e-02 | 5.96 | 8.3 | 1.3e-16 | -0.71 | 0.10 | 0.45 | FALSE |
60 | GTEx | Stomach | RP11-33B1.1 | 0.11 | 0.08 | lasso | 3 | 0.09 | 4.3e-05 | -8.07 | 8.5 | 2.2e-17 | -0.91 | 0.11 | 0.88 | FALSE |
61 | GTEx | Testis | RP11-33B1.1 | 0.37 | 0.46 | lasso | 6 | 0.47 | 2.2e-23 | -7.92 | 8.1 | 4.3e-16 | -0.89 | 0.97 | 0.03 | FALSE |
62 | GTEx | Testis | RP11-33B1.4 | 0.23 | 0.31 | enet | 16 | 0.37 | 1.5e-17 | -7.95 | 8.9 | 5.1e-19 | -0.97 | 0.04 | 0.96 | FALSE |
63 | GTEx | Thyroid | PDE5A | 0.09 | 0.04 | lasso | 3 | 0.04 | 6.9e-04 | 5.21 | 5.4 | 5.4e-08 | -0.32 | 0.23 | 0.20 | TRUE |
64 | GTEx | Thyroid | RP11-33B1.1 | 0.18 | 0.21 | lasso | 3 | 0.24 | 1.0e-18 | -8.41 | 8.3 | 9.5e-17 | -0.77 | 0.90 | 0.10 | FALSE |
65 | GTEx | Thyroid | RP11-33B1.4 | 0.07 | 0.07 | lasso | 3 | 0.05 | 1.8e-04 | -8.97 | 8.7 | 2.6e-18 | -0.99 | 0.02 | 0.98 | FALSE |
66 | GTEx | Uterus | RP11-33B1.4 | 0.23 | 0.24 | lasso | 4 | 0.16 | 4.9e-04 | -7.91 | -8.0 | 1.2e-15 | 0.83 | 0.12 | 0.32 | FALSE |
67 | GTEx | Vagina | RP11-33B1.1 | 0.32 | 0.25 | lasso | 10 | 0.27 | 5.3e-07 | -8.13 | 8.5 | 1.7e-17 | -0.90 | 0.29 | 0.68 | FALSE |
68 | GTEx | Whole Blood | C4orf3 | 0.11 | 0.16 | lasso | 6 | 0.16 | 3.0e-14 | -8.41 | -8.0 | 1.5e-15 | 0.91 | 0.18 | 0.82 | FALSE |
69 | GTEx | Whole Blood | RP11-33B1.1 | 0.06 | 0.06 | lasso | 4 | 0.05 | 2.3e-05 | -7.85 | 7.6 | 2.7e-14 | -0.90 | 0.34 | 0.66 | FALSE |
70 | GTEx | Whole Blood | RP11-33B1.4 | 0.13 | 0.16 | lasso | 9 | 0.15 | 1.4e-13 | -7.95 | -8.0 | 1.3e-15 | 0.91 | 0.96 | 0.04 | FALSE |
71 | NTR | Blood | PDE5A | 0.03 | 0.05 | lasso | 6 | 0.04 | 2.0e-13 | -7.95 | 8.0 | 9.9e-16 | -0.91 | 0.74 | 0.26 | FALSE |
72 | NTR | Blood | USP53 | 0.10 | 0.10 | bslmm | 482 | 0.11 | 2.6e-34 | 5.94 | 5.6 | 2.1e-08 | -0.14 | 1.00 | 0.00 | TRUE |
73 | ROSMAP | Brain Pre-frontal Cortex | PDE5A | 0.02 | 0.00 | bslmm | 442 | 0.01 | 7.3e-03 | 5.12 | 7.3 | 2.8e-13 | -0.75 | 0.10 | 0.46 | FALSE |
74 | ROSMAP | Brain Pre-frontal Cortex | USP53 | 0.06 | 0.04 | blup | 470 | 0.05 | 5.7e-07 | -8.67 | 8.1 | 5.9e-16 | -0.83 | 0.12 | 0.88 | FALSE |
75 | ROSMAP | Brain Pre-frontal Cortex | RP11-33B1.1 | 0.22 | 0.42 | lasso | 5 | 0.42 | 1.4e-59 | -7.45 | 8.1 | 6.7e-16 | -0.87 | 1.00 | 0.00 | FALSE |
76 | YFS | Blood | USP53 | 0.06 | 0.05 | bslmm | 479 | 0.06 | 8.1e-20 | 5.94 | 7.3 | 2.5e-13 | -0.27 | 1.00 | 0.00 | FALSE |
77 | The Cancer Genome Atlas | Colon Adenocarcinoma | FABP2 | 0.24 | 0.20 | lasso | 9 | 0.25 | 1.8e-14 | 6.24 | -8.2 | 2.3e-16 | 0.86 | 0.06 | 0.94 | FALSE |
78 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | USP53 | 0.07 | 0.05 | blup | 88 | 0.04 | 7.9e-06 | 6.70 | 6.8 | 8.7e-12 | -0.55 | 0.68 | 0.18 | FALSE |
79 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | PDE5A | 0.10 | 0.04 | lasso | 2 | 0.04 | 2.6e-03 | -7.45 | 7.0 | 2.1e-12 | -0.77 | 0.04 | 0.28 | FALSE |
80 | The Cancer Genome Atlas | Thyroid Carcinoma | USP53 | 0.11 | 0.03 | blup | 88 | 0.07 | 5.8e-07 | 5.95 | 8.7 | 2.8e-18 | -0.58 | 0.80 | 0.08 | TRUE |