Hub : Genes

PADI2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Lung	0.2072	0.0455	7.7e-10	0.236	NA	0.240	NA	0.245	4.7e-18	NA	2.4e-18	NA	1.0e-18
2	GTEx	Muscle Skeletal	0.0323	0.0144	5.7e-03	0.033	NA	0.014	NA	0.031	3.4e-04	NA	1.4e-02	NA	4.6e-04
3	GTEx	Skin Sun Exposed Lower leg	0.0860	0.0350	9.6e-04	0.063	NA	0.069	NA	0.062	6.2e-06	NA	2.3e-06	NA	6.8e-06
4	GTEx	Spleen	0.5020	0.0830	7.4e-08	0.476	NA	0.365	NA	0.463	6.4e-14	NA	2.8e-10	NA	1.9e-13
5	GTEx	Whole Blood	0.4210	0.0460	0.0e+00	0.505	NA	0.495	NA	0.502	2.9e-53	NA	8.4e-52	NA	6.3e-53
6	METSIM	Adipose	0.0904	0.0244	8.3e-13	0.130	0.092	0.125	0.121	0.123	6.2e-19	1.1e-13	2.8e-18	1.4e-17	6.9e-18
7	NTR	Blood	0.3578	0.0321	0.0e+00	0.451	0.396	0.447	0.451	0.452	4.7e-164	3.1e-138	2.0e-162	4.1e-164	7.9e-165
8	ROSMAP	Brain Pre-frontal Cortex	0.1844	0.0496	1.5e-04	0.007	0.042	0.046	0.064	0.011	4.3e-02	4.0e-06	1.1e-06	1.3e-08	1.4e-02
9	YFS	Blood	0.3219	0.0358	0.0e+00	0.230	0.222	0.240	0.243	0.234	9.0e-74	7.1e-71	2.4e-77	2.4e-78	3.9e-75
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0681	0.0329	3.8e-04	0.031	0.028	0.010	NA	0.024	1.6e-04	3.8e-04	2.4e-02	NA	8.8e-04
11	TCGA	Lung Adenocarcinoma	0.0496	0.0288	6.9e-03	-0.002	0.007	0.003	NA	0.001	8.8e-01	4.6e-02	1.3e-01	NA	2.2e-01
12	TCGA	Lung Squamous Cell Carcinoma	0.0529	0.0265	4.3e-04	0.007	0.019	0.017	NA	0.017	4.8e-02	2.6e-03	4.2e-03	NA	4.7e-03
13	TCGA	Prostate Adenocarcinoma	0.0440	0.0235	4.4e-03	0.016	0.024	0.015	NA	0.026	7.5e-03	1.2e-03	8.6e-03	NA	8.6e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.6	1.0	5.9	-0.5	1.5	0.1	-0.2	-0.6	-0.5	-0.2	2.4	0.4	-1.1	-0.4	-1.1	-1.1
Bipolar Disorder or Schizophrenia	0.7	1.7	8.9	-0.6	3.0	0.4	-0.3	-0.6	-0.8	-0.2	2.6	0.9	-1.1	-0.8	-1.2	-0.9
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	0.3	0.4	-0.3	0.4	0.4	0.0	0.4	-0.6	0.1	0.3	0.6	-0.1	0.6
Depression (Nagel 2018)	0.4	0.7	5.3	-0.3	2.3	-1.0	-0.3	-0.2	-0.9	-0.3	-0.2	0.1	0.2	0.1	0.2	0.9
Intelligence (Savage-Jansen 2018)	0.1	0.4	1.9	-0.4	0.8	0.6	-0.4	-0.3	-0.6	-0.3	0.5	0.5	0.3	-1.4	0.8	0.8
Neuroticism (Nagel 2018)	0.1	0.3	0.7	-0.6	0.6	0.1	-0.5	-0.5	-0.9	-0.5	-0.8	-0.8	0.3	0.2	-0.1	0.7
Schizophrenia (2018)	0.5	0.9	7.1	-0.4	2.7	0.2	-0.2	-0.4	-0.6	-0.0	1.6	0.8	-0.6	-0.7	-0.7	-0.3
Schizophrenia vs Biploar Disorder	0.7	0.9	2.5	1.2	-1.6	-0.6	1.3	1.2	1.2	1.2	-0.5	0.8	0.0	0.1	0.8	0.2
Worry (Nagel 2018)	0.1	0.1	0.8	0.2	-0.7	-0.9	0.2	0.2	0.2	0.2	-0.2	0.1	-0.0	0.1	-0.6	-0.4
Alzheimer’s Disease (in mother)	0.2	0.3	0.7	-0.5	0.8	-0.1	-0.5	-0.6	-0.7	-0.6	-0.3	0.0	0.5	0.2	0.6	0.8
Alzheimer’s Disease (in father)	0.5	0.6	1.6	-0.2	0.2	0.8	-0.3	-0.3	-0.4	-0.4	1.1	0.0	-1.2	-1.2	-1.0	-1.3
Alzheimer’s Disease (including proxy)	0.3	0.4	1.4	-0.5	1.2	0.6	-0.5	-0.5	-0.8	-0.5	1.1	0.5	-0.4	-0.9	-0.1	-0.3
Crohns Disease (2017)	0.2	0.4	2.2	0.3	0.3	-1.5	0.3	0.3	0.2	0.4	0.2	1.0	0.6	0.5	0.3	0.2
Irritable Bowel Disease (IBD)	0.8	2.0	6.0	1.5	-1.9	-2.5	1.7	1.5	1.7	1.6	0.3	1.7	-0.1	0.2	0.2	-0.7
Ulcerative Colitis (UC)	1.5	2.8	7.5	1.9	-2.7	-2.2	2.0	1.9	2.3	1.9	0.5	1.6	-0.6	-0.1	0.2	-0.8
Major Depression (MDD)	0.7	0.9	3.6	-0.2	-0.3	-0.8	-0.1	-0.2	-0.1	-0.0	-1.1	-0.2	1.4	0.8	1.8	1.9
Reaction Time	0.3	0.6	1.3	-0.8	0.9	1.1	-0.8	-0.8	-0.8	-0.8	-0.4	-0.4	-0.5	-1.0	-0.6	-0.2
Verbal and Numeric Reasoning (VNR)	0.3	0.6	2.6	-0.5	0.7	0.0	-0.5	-0.5	-0.7	-0.5	-0.4	0.1	0.7	-1.0	1.4	1.6
Breast Cancer	0.1	0.3	1.2	0.0	1.0	1.1	-0.1	-0.0	-0.2	-0.1	0.5	0.0	0.4	0.5	-0.5	-0.4
Ovarian Cancer	0.6	0.7	3.4	-0.7	1.8	0.7	-0.6	-0.7	-1.1	-0.7	0.3	-0.2	-0.9	-0.8	-0.5	-0.9
Prostate Cancer	0.2	0.3	1.5	0.2	-0.8	-1.2	0.3	0.2	0.1	0.2	-1.1	0.2	-0.6	-0.3	-0.1	-0.2
Age at First Birth	0.9	1.4	2.9	-1.4	1.0	0.6	-1.3	-1.4	-1.2	-1.2	-1.6	-1.7	0.8	0.9	-0.9	0.1
Bipolar Disorder (2011)	0.6	0.6	4.1	-0.3	1.2	0.4	-0.4	-0.4	-0.3	-0.3	2.0	0.4	-0.7	-0.2	-0.6	-0.1
Body Mass Index (BMI) (2010)	0.9	1.2	2.0	-1.3	1.3	1.4	-1.4	-1.3	-1.1	-1.4	0.4	-0.9	-0.5	-0.8	-1.1	-0.2
Coronary Artery Disease (CAD)	1.2	1.4	2.9	-1.1	0.6	1.5	-1.3	-1.0	-1.2	-1.4	-0.3	-0.8	-1.4	-1.7	-0.8	-1.3
Crohns Disease (2012)	0.2	0.3	1.6	0.1	0.3	-1.3	0.1	0.1	-0.0	0.2	-0.6	0.4	1.0	0.7	-0.3	0.6
Mean Putamen Volume	0.1	0.1	0.6	0.0	0.3	-0.0	0.0	0.1	0.1	0.1	-0.2	0.3	0.4	-0.2	0.6	0.8
Fasting Glucose	1.5	1.8	2.5	-1.2	1.6	1.1	-1.2	-1.1	-1.4	-1.2	-1.6	-1.3	-1.4	-1.6	-1.5	-1.3
HbA1C	0.2	0.2	1.1	0.2	0.4	-0.0	0.3	0.3	-0.1	0.3	1.1	0.3	-0.4	-0.5	-0.7	-0.7
HDL Cholesterol	0.1	0.2	0.8	0.1	0.0	-0.0	-0.1	0.0	0.3	-0.1	0.1	0.1	-0.6	-0.6	-0.9	-0.8
LDL Cholesterol	2.4	3.8	8.9	1.9	-3.0	-2.3	1.9	1.9	2.2	1.8	0.0	1.2	1.9	2.1	2.0	1.6
Lupus	0.6	0.8	1.6	-1.0	1.0	1.0	-1.0	-1.0	-0.9	-1.0	-0.5	-1.0	-0.8	-0.4	-1.3	-0.5
Neuroticism (2016)	1.3	1.8	3.2	-1.4	1.4	1.2	-1.4	-1.3	-1.6	-1.4	-0.5	-1.2	-1.4	-1.8	-1.6	-0.9
Primary Biliary Cirrhosis	0.1	0.1	0.8	-0.3	0.3	-0.5	-0.3	-0.3	-0.2	-0.3	-0.0	-0.2	0.9	0.5	-0.1	0.4
Rheumatoid Arthritis	4.9	6.8	14.0	3.1	-3.7	-2.6	3.3	3.1	3.5	3.0	0.8	2.3	0.3	2.0	2.3	0.4
Schizophrenia (2014)	0.5	1.2	6.1	-0.1	2.3	0.1	0.1	-0.2	-0.4	0.2	2.5	1.1	-0.9	-0.7	-0.8	-0.9
Triglycerides	0.2	0.4	1.3	-0.6	1.1	0.9	-0.3	-0.6	-0.8	-0.3	0.2	-0.6	0.2	0.9	0.2	0.5
Type 2 Diabetes (T2D) (2012)	0.3	0.4	2.6	0.4	0.2	0.3	0.7	0.3	0.5	0.7	1.6	0.3	0.2	0.9	-0.2	-0.0
Ulcerative Colitis	1.9	2.8	6.0	1.9	-2.3	-2.4	2.1	2.0	2.3	2.0	0.3	1.6	-0.3	0.7	0.6	-0.4
Blood Eosinophil Count	0.2	1.4	2.8	-1.1	1.7	1.5	-1.1	-1.1	-1.3	-1.1	1.1	-1.5	1.1	0.9	0.5	1.0
Blood Platelet Count	0.1	1.2	2.4	-0.8	-0.8	1.1	-0.8	-0.8	-0.5	-0.9	-1.2	-1.3	-1.4	-1.5	-1.4	-1.3
Blood Red Count	1.3	12.4	30.9	4.0	-5.6	-4.2	4.1	4.0	4.4	4.0	0.0	3.0	2.1	2.3	2.7	1.9
Blood White Count	0.1	0.8	2.1	-1.0	0.6	0.2	-1.1	-1.1	-1.0	-1.1	-0.8	-1.4	-0.3	-0.8	-0.4	-0.8
Heel T-Score	0.9	7.5	17.8	-2.6	2.7	2.6	-2.5	-2.5	-2.9	-2.5	-2.1	-2.4	-2.8	-2.6	-4.2	-2.6
BMI	1.3	7.3	16.0	-3.4	3.9	2.7	-3.5	-3.3	-4.0	-3.3	-1.4	-2.6	0.4	-1.0	-0.7	0.4
Height	5.7	109.1	204.5	11.4	-14.3	-12.7	11.8	11.5	13.0	11.3	3.4	7.2	6.4	8.8	11.0	7.2
Waist Hip Ratio (WHR)	0.9	3.9	11.5	2.0	-3.4	-2.5	2.1	2.0	2.3	1.9	-0.2	0.4	1.7	1.8	2.0	0.9
Systolic Blood Pressure	0.1	0.3	0.8	0.4	-0.7	-0.3	0.4	0.4	0.5	0.4	0.9	0.4	0.3	-0.4	0.7	0.0
Smoking Status	0.4	1.0	1.8	1.3	0.6	-0.7	1.2	1.3	1.2	1.4	1.1	1.0	-0.4	1.1	-0.0	-0.8
Allergy or Eczema	0.5	1.3	7.8	1.1	-0.6	-1.0	1.1	1.0	1.1	1.1	2.8	1.3	-0.0	0.2	-0.0	-0.6
Cardiovascular Disease	0.1	0.3	2.2	-0.1	-1.5	0.6	-0.3	-0.2	0.5	-0.3	-0.6	-0.4	0.4	-0.4	0.4	0.4
Hypothyroidism (self reported)	0.5	1.2	2.7	-1.1	0.3	0.9	-0.9	-1.2	-0.9	-1.1	1.6	-0.9	-1.2	-1.5	-0.5	-1.4
Respiratory disease	0.9	2.0	7.7	0.8	-0.2	-0.7	0.8	0.8	0.7	0.7	1.8	0.5	1.9	2.0	2.8	2.0
Type 2 Diabetes (T2D) (2018)	0.2	0.5	1.6	-0.6	-0.0	0.1	-0.7	-0.7	-0.3	-0.7	0.7	-0.6	1.2	1.1	-0.1	0.8
Lung FEV1/FVC ratio	18.2	92.3	144.0	-10.8	10.7	11.0	-11.1	-10.8	-12.0	-10.8	-4.4	-7.8	-6.2	-9.2	-10.4	-6.1
Lung FVC	2.8	14.1	38.0	3.8	-6.2	-3.7	4.0	3.8	4.9	3.8	0.3	2.0	2.3	3.3	4.5	2.7
Neuroticism	0.4	0.9	1.7	1.2	-0.4	-1.1	1.3	1.3	0.7	1.3	-0.7	0.9	0.2	0.9	-0.6	0.0
Chronotype (morning person)	0.3	0.7	1.6	-0.5	-1.3	0.6	-0.5	-0.6	-0.3	-0.6	-0.7	-1.0	-1.1	-1.3	-0.8	-1.2
Hair Pigment	0.0	1.4	11.0	-0.9	0.5	3.3	-0.9	-0.8	-1.0	-0.9	0.3	-1.4	-0.1	0.3	-0.1	0.1
Tanning	0.2	2.0	4.5	1.8	-0.8	-2.1	1.9	1.8	1.7	1.8	-0.4	2.1	-0.4	0.5	0.0	-0.4
Hand grip strength (left)	0.1	0.2	1.1	-0.1	-0.3	0.2	-0.1	-0.0	0.2	-0.1	0.4	-0.6	0.3	0.2	0.9	1.0
Number of treatments/medications taken	0.4	0.6	2.0	-0.8	0.5	1.4	-0.8	-0.8	-0.8	-0.8	0.2	-0.8	-0.3	-0.5	-1.0	-0.8
Average weekly spirits intake	2.8	3.5	5.7	2.3	-1.5	-1.8	2.4	2.4	1.7	2.3	-0.6	1.9	1.6	1.6	1.8	1.5
Sensitivity / hurt feelings	0.4	0.7	2.7	0.1	-0.2	-0.4	0.1	0.1	-0.1	0.1	-1.2	-0.1	1.4	1.2	0.9	1.6
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.0	-0.6	1.4	-0.4	-0.7	-0.6	-1.1	-0.6	-1.4	-0.3	0.7	-0.1	0.2	1.3
Hearing difficulty/problems: Yes	0.2	0.2	1.5	-0.3	0.4	0.2	-0.1	-0.2	-0.4	-0.2	0.4	-0.3	-1.2	-0.7	0.2	-0.6
Relative age of first facial hair	0.3	0.5	0.9	-0.7	1.0	0.8	-0.6	-0.7	-0.6	-0.7	-0.0	-0.5	-1.0	-0.6	-0.7	-0.9
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	3.1	0.7	-0.2	-1.0	0.6	0.7	0.6	0.7	-0.5	0.7	1.8	1.4	0.9	1.2
Ever used hormone-replacement therapy (HRT)	1.1	1.5	7.2	-0.4	-1.3	-0.6	-0.2	-0.4	0.1	-0.3	-0.2	-0.9	-1.7	-1.0	-2.0	-2.7
Ever had hysterectomy (womb removed)	0.7	0.8	2.9	-0.6	0.2	-0.0	-0.4	-0.6	-0.2	-0.6	0.6	-0.3	-1.7	-1.2	-1.1	-1.7
Systolic blood pressure, automated reading	0.1	0.4	1.1	0.4	-0.8	-0.0	0.4	0.4	0.4	0.4	1.1	0.5	1.0	0.2	0.9	0.7
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.4	-0.2	1.3	0.5	-0.4	-0.3	-0.1	-0.4	1.1	0.4	1.1	0.8	1.3	1.6
Angina	0.6	0.8	2.0	1.2	-0.3	-1.0	1.2	1.1	1.0	1.1	0.8	1.4	0.4	0.6	0.5	-0.0
Medication for hormone replacement therapy	0.3	0.4	1.3	-0.7	-0.8	0.3	-0.5	-0.7	-0.1	-0.6	-0.8	-1.1	-0.3	-0.2	-0.2	-0.7
Vitamin and mineral supplements	0.4	0.5	1.4	0.3	-1.0	-0.2	0.3	0.4	0.4	0.3	0.7	0.0	1.1	0.6	1.2	1.2
Supplements: Zinc	0.4	0.4	1.6	-0.1	0.1	0.8	-0.1	-0.2	-0.2	-0.1	-1.3	-0.1	1.1	0.4	0.7	1.0
Medication: Co-codamol	0.5	0.6	1.4	-0.7	0.2	0.9	-0.6	-0.6	-0.8	-0.6	-0.3	-1.1	-1.1	-0.4	-1.0	-1.2
Medication: Metformin	0.2	0.3	2.8	-0.2	0.0	-0.2	-0.2	-0.3	0.1	-0.3	1.7	0.2	0.3	0.6	0.0	0.1
Diabetes (father)	0.1	0.1	1.2	-0.1	0.4	0.1	-0.1	-0.3	0.1	-0.2	1.1	-0.0	-0.3	0.3	0.2	-0.4
Diabetes (mother)	0.7	0.9	5.2	0.1	-0.2	-0.1	0.0	0.1	0.2	0.0	-0.5	-0.4	1.6	1.4	1.4	2.3
Severe depression (siblings)	0.3	0.4	0.9	0.7	0.3	-0.1	0.8	0.8	0.4	0.8	0.7	0.5	-0.4	0.5	-0.6	-1.0
Pack years adult smoking proportion	1.0	1.5	2.7	0.9	1.4	-0.9	0.8	0.9	0.5	0.8	1.6	1.3	1.6	1.4	1.6	1.6
Impedance of leg (right)	1.2	5.9	26.5	2.5	-5.2	-2.9	2.7	2.5	3.5	2.5	-0.4	1.2	-0.9	0.4	0.2	-1.1
Leg fat-free mass (left)	1.6	8.4	19.7	2.6	-1.4	-2.8	2.5	2.7	2.2	2.6	1.4	2.1	3.8	3.2	4.4	4.0
Trunk fat percentage	0.1	0.6	2.0	-0.1	-0.7	-1.0	-0.1	-0.1	0.0	-0.2	1.1	-0.4	1.1	0.9	1.4	0.8
Hand grip strength (right)	0.1	0.3	0.9	0.3	-0.9	-0.6	0.4	0.4	0.7	0.3	0.9	-0.5	-0.5	0.1	0.8	0.3
Townsend deprivation index at recruitment	0.3	0.4	1.5	-0.5	0.9	1.2	-0.6	-0.5	-0.9	-0.5	-0.1	-0.4	0.5	-0.3	-0.2	-0.2
Current tobacco smoking	0.3	0.5	2.7	0.4	1.3	-0.1	0.2	0.3	0.4	0.3	0.7	0.3	0.7	1.6	0.6	0.4
Average weekly fortified wine intake	1.1	1.3	5.2	0.5	0.3	-0.9	0.3	0.5	0.5	0.4	0.4	-0.1	2.3	2.3	1.4	1.7
Maternal smoking around birth	0.3	0.4	2.5	-0.3	0.8	-0.0	-0.3	-0.3	-0.3	-0.2	1.6	0.6	-0.1	-0.7	0.6	0.5
Fed-up feelings	0.1	0.2	0.9	-0.2	0.4	-0.1	-0.2	-0.2	-0.2	-0.2	-0.8	-0.1	0.7	0.3	0.2	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.7	2.8	-0.6	1.7	-0.6	-0.6	-0.6	-1.0	-0.7	-0.2	-0.4	-1.1	-0.8	-1.0	-0.7
Relative age voice broke	0.4	0.7	1.8	-0.7	1.2	1.3	-0.6	-0.7	-0.7	-0.7	0.8	-0.3	-0.8	-0.4	-0.9	-0.7
Taking other prescription medications	1.1	1.8	2.7	1.4	-0.5	-0.6	1.4	1.4	1.3	1.4	1.5	1.5	1.5	1.5	1.6	1.1
Age when periods started (menarche)	0.1	0.3	1.0	0.2	-0.5	-0.3	0.2	0.3	0.5	0.3	-0.9	0.2	0.2	-0.0	0.7	1.0
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	4.1	-0.3	-1.6	0.1	-0.1	-0.3	0.2	-0.3	-1.2	-1.0	-1.7	-1.7	-1.0	-2.0
Heel bone mineral density (BMD) T-score, automated (left)	1.4	3.2	6.0	-2.0	2.4	0.6	-2.0	-2.0	-2.3	-1.9	-1.6	-1.8	-0.8	-1.1	-2.4	-0.8
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	3.1	-1.0	1.8	1.2	-1.0	-1.0	-1.1	-1.0	0.7	-0.7	-0.0	-0.5	0.5	0.3
Qualifications: CSEs or equivalent	0.3	0.3	1.1	0.5	-0.2	-0.2	0.5	0.6	0.3	0.6	-0.1	0.2	0.9	1.0	0.6	0.9
Serious illness, injury or assault to yourself	0.2	0.3	2.0	0.1	1.4	-0.1	-0.1	0.1	-0.2	-0.0	0.9	0.1	0.3	0.8	-0.3	-0.1
High blood pressure	0.1	0.2	0.8	-0.3	-0.0	0.3	-0.5	-0.4	-0.0	-0.4	0.0	-0.0	0.9	-0.2	0.5	0.6
Hayfever, allergic rhinitis or eczema	0.2	0.4	2.6	0.2	-0.6	-1.1	0.4	0.2	0.4	0.2	1.6	0.3	-0.1	-0.2	-0.5	-0.8
Multivitamins +/- minerals	0.1	0.1	0.5	-0.1	0.7	0.4	-0.1	-0.1	-0.2	-0.1	-0.5	0.2	-0.1	-0.2	0.2	0.0
Stomach or abdominal pain in last month	0.3	0.4	1.8	-0.4	1.3	-0.1	-0.5	-0.4	-0.5	-0.4	1.0	-0.4	-0.6	-0.3	-0.7	-0.4
Supplements: Glucosamine	0.8	1.0	1.5	-1.1	0.9	0.5	-1.1	-1.2	-1.0	-1.1	0.1	-0.8	-1.0	-1.1	-1.2	-1.1
Diverticular disease/diverticulitis (self-reported)	0.2	0.2	0.4	0.5	0.1	-0.4	0.5	0.6	0.2	0.5	0.3	0.7	0.4	0.5	-0.0	0.4
Medication: Atenolol	0.6	0.8	1.9	-1.1	0.0	1.4	-1.2	-1.2	-0.8	-1.1	-0.9	-1.0	0.3	-0.2	-0.6	0.2
Medication: Levothyroxine sodium	0.2	0.3	1.3	-0.4	0.1	0.3	-0.3	-0.4	-0.3	-0.4	1.1	-0.0	-0.9	-0.9	0.5	-0.3
Sitting height	4.2	29.8	44.6	6.1	-6.6	-6.1	6.3	6.3	6.7	6.1	2.8	4.2	3.5	4.4	6.1	3.8
Chronic bronchitis/emphysema (father)	0.8	1.0	4.5	-0.5	1.0	0.2	-0.5	-0.4	-0.4	-0.4	-0.8	-0.7	2.1	1.8	0.8	1.1
High blood pressure (mother)	0.8	1.1	1.9	1.3	-1.4	-1.2	1.3	1.3	1.3	1.4	0.0	1.2	0.1	0.1	-0.7	-0.2
Body mass index (BMI)	0.6	2.7	8.8	-1.9	3.0	1.3	-2.1	-1.9	-2.5	-1.9	0.5	-1.1	0.9	-0.1	0.1	0.8
Impedance of leg (left)	1.1	5.5	21.9	2.5	-4.7	-2.8	2.7	2.4	3.4	2.4	0.1	1.1	-1.0	0.7	0.1	-1.3
Leg predicted mass (left)	1.6	8.3	19.4	2.5	-1.5	-2.8	2.5	2.6	2.2	2.5	1.4	2.1	3.8	3.2	4.4	4.0
Trunk fat mass	0.5	2.0	6.4	0.7	-1.1	-1.8	0.7	0.7	0.8	0.7	1.4	0.2	2.1	1.7	2.5	1.9
Waist circumference	1.3	4.8	12.7	1.5	-1.2	-2.3	1.4	1.5	1.4	1.4	1.6	1.0	3.5	3.0	3.6	2.9
Number of incorrect matches in round	0.8	1.3	3.0	1.2	-1.7	-0.9	1.4	1.2	1.5	1.2	0.7	1.1	0.3	0.1	1.6	0.3
Past tobacco smoking	0.4	0.7	1.8	-0.7	0.8	0.7	-0.8	-0.8	-0.8	-0.8	0.5	-0.3	1.3	0.6	0.8	1.2
Alcohol usually taken with meals	0.5	0.7	2.5	-0.2	-1.3	-0.3	-0.0	-0.2	0.2	-0.3	0.1	-0.6	-1.6	-1.4	-0.9	-1.3
Nervous feelings	0.3	0.6	2.1	-0.9	-0.3	0.5	-0.9	-1.0	-0.6	-0.9	-1.5	-0.9	0.2	-0.6	-0.3	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.4	2.0	-0.2	1.4	-0.3	-0.3	-0.2	-0.4	-0.3	0.7	-0.1	-0.9	-0.5	-1.1	-0.5
Hearing difficulty/problems with background noise	0.2	0.3	1.0	0.5	-1.0	-0.2	0.7	0.6	0.2	0.6	-0.7	0.2	-0.4	-0.3	0.3	-0.1
Hair/balding pattern: Pattern 2	0.3	0.4	2.1	-0.1	-1.3	-0.6	-0.2	-0.2	0.5	-0.2	-1.4	-0.4	0.3	0.4	-0.8	0.3
Had menopause	0.4	0.4	2.0	-0.4	-0.2	-0.1	-0.3	-0.4	-0.3	-0.5	0.8	-0.6	-0.5	-0.6	-1.2	-1.4
Had other major operations	0.7	0.9	1.7	-1.1	0.4	0.5	-0.9	-1.1	-0.9	-1.0	-0.6	-0.9	-1.2	-0.8	-1.3	-1.1
Forced vital capacity (FVC)	7.6	29.3	49.4	5.8	-7.0	-5.4	5.9	5.9	6.5	5.8	0.9	3.8	4.0	5.1	6.5	4.9
Heel bone mineral density (BMD) T-score, automated (right)	1.3	3.0	7.8	-1.9	1.8	0.6	-1.9	-1.8	-2.2	-1.8	-1.7	-1.7	-0.7	-1.2	-2.8	-1.1
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	1.1	0.2	1.1	0.4	0.1	0.2	-0.2	0.1	0.7	0.5	-0.1	0.2	-0.6	0.1
Qualifications: None of the above	0.6	1.3	3.4	0.9	-0.9	-1.1	1.0	0.8	1.2	0.9	1.2	1.0	-1.7	-0.3	-1.2	-1.9
Financial difficulties in last 2 years	0.3	0.4	1.4	0.1	1.0	-0.4	0.1	0.1	-0.1	0.1	0.2	0.8	1.2	0.7	0.9	0.8
Mouth/teeth dental problems	0.6	0.9	1.7	-0.8	0.5	0.2	-0.9	-0.8	-1.0	-0.7	-1.3	-1.3	1.3	1.1	0.3	1.0
Heart attack	0.7	0.9	2.2	1.1	0.1	-0.7	1.1	1.1	0.8	1.1	0.3	1.1	0.8	1.5	0.9	0.8
Allergy	1.0	2.3	7.2	-1.3	1.4	2.1	-1.5	-1.3	-1.4	-1.3	-2.7	-1.2	-1.0	-1.2	-1.4	-0.5
Pain all over the body in last month	1.6	1.8	3.5	1.5	-1.6	-0.9	1.4	1.5	1.2	1.5	0.6	0.8	1.5	1.9	1.5	0.7
Diabetes (self-reported)	0.2	0.4	1.5	0.1	-0.4	-0.5	0.0	0.1	0.1	0.0	0.4	0.2	1.2	1.0	0.4	1.1
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.1	-0.8	0.6	0.5	-0.7	-0.8	-0.8	-0.8	0.8	-0.5	-0.3	-1.0	-0.5	-0.5
Medication: Ramipril	0.3	0.3	1.1	-0.4	0.2	0.1	-0.5	-0.4	-0.4	-0.5	-1.0	-0.6	0.9	0.1	0.8	0.6
Medication: Simvastatin	1.7	2.4	3.9	1.9	-1.6	-2.0	1.8	1.9	1.9	1.8	0.4	1.8	1.0	1.1	1.1	0.8
Fluid intelligence score	0.3	0.6	2.4	-0.6	0.6	0.4	-0.7	-0.5	-0.8	-0.6	-0.7	-0.2	0.9	-0.8	0.7	1.6
Illnesses of siblings	1.2	1.7	3.5	-1.5	1.9	1.6	-1.6	-1.4	-1.8	-1.4	-0.2	-1.2	-0.1	-1.2	-0.4	0.0
Neuroticism score	0.1	0.2	1.5	0.2	0.0	-0.5	0.3	0.3	-0.1	0.3	-0.6	0.2	-0.4	-0.1	-1.2	-0.5
Weight	1.2	6.0	15.5	1.9	-1.5	-2.7	1.9	2.0	1.7	1.9	1.6	1.4	3.3	2.9	3.9	3.4
Impedance of arm (right)	1.2	5.7	26.1	2.4	-5.1	-2.8	2.6	2.3	3.4	2.3	1.2	1.4	-0.6	0.4	1.1	-0.9
Arm fat percentage (right)	0.3	1.0	1.9	-1.3	1.1	0.2	-1.3	-1.3	-1.4	-1.3	1.2	-0.9	0.6	-0.1	0.4	0.3
Trunk fat-free mass	2.2	12.6	25.3	3.5	-2.4	-3.9	3.5	3.6	3.3	3.5	1.5	2.7	3.9	3.6	5.0	4.3
Hip circumference	1.1	4.8	12.7	1.5	-1.4	-2.2	1.4	1.5	1.4	1.5	1.4	1.1	3.4	2.8	3.6	3.1
Time employed in main current job	1.0	1.2	2.9	1.0	-0.3	-0.8	1.1	0.9	1.3	0.9	1.7	1.7	0.7	0.6	1.4	0.7
Alcohol intake versus 10 years previously	0.2	0.3	1.1	0.3	0.4	-0.2	0.3	0.3	0.3	0.4	0.9	0.6	-1.1	-0.0	-0.3	-0.6
Father’s age at death	2.2	3.0	7.8	-2.2	0.6	1.2	-2.2	-2.2	-2.1	-2.2	-2.0	-2.8	0.5	-0.2	-0.9	0.3
Worrier / anxious feelings	0.2	0.4	0.9	0.7	-0.4	-0.6	0.8	0.7	0.4	0.7	0.7	1.0	0.7	0.4	-0.1	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	1.7	0.9	1.0	-0.8	0.8	0.9	0.3	0.9	0.7	1.3	1.1	0.6	0.9	1.0
Falls in the last year	1.5	2.1	7.2	-1.6	2.7	1.3	-1.6	-1.6	-1.9	-1.6	-0.2	-1.3	1.0	0.8	0.5	0.8
Hair/balding pattern: Pattern 3	0.1	0.1	0.7	-0.1	0.8	-0.1	-0.0	-0.1	-0.6	-0.0	-0.1	0.4	0.3	-0.1	0.3	-0.0
Number of live births	0.8	1.2	2.3	1.2	0.2	-0.6	1.1	1.2	0.8	1.2	0.9	1.5	1.0	1.4	1.2	1.1
Forced expiratory volume in 1-second (FEV1)	1.4	4.7	14.0	2.2	-3.7	-1.8	2.2	2.2	2.6	2.1	-0.2	1.2	1.6	1.7	2.7	2.1
Pulse rate	0.1	0.2	0.9	-0.4	0.8	0.1	-0.5	-0.4	-0.4	-0.4	0.9	-0.5	0.1	-0.2	0.1	-0.2
Happiness	1.1	1.3	5.6	0.3	1.1	-0.1	0.1	0.3	0.2	0.2	1.2	0.6	1.7	1.7	1.6	2.4
Noisy workplace	0.7	0.9	4.9	-0.9	2.2	0.9	-1.0	-1.0	-1.0	-0.9	0.6	-0.6	0.0	0.4	0.1	-0.2
Qualifications: A levels/AS levels or equivalent	0.0	0.1	0.5	0.3	-0.3	0.2	0.2	0.3	0.0	0.2	0.7	0.3	0.0	-0.1	0.1	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	3.1	0.2	-1.4	-0.6	0.3	0.2	0.5	0.2	-0.2	-0.1	0.7	0.0	1.8	1.7
Mouth/teeth dental problems: Dentures	0.2	0.3	1.0	-0.0	-0.4	0.8	0.1	-0.0	-0.0	-0.1	-0.3	-0.1	-0.9	-0.9	-0.6	-1.0
Asthma	1.4	2.8	13.1	0.6	-0.2	-0.6	0.7	0.6	0.7	0.6	2.0	0.6	2.3	1.9	3.6	2.7
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	1.6	-1.0	1.2	0.8	-1.0	-1.0	-1.3	-1.0	0.4	-0.8	-0.9	-0.9	-0.6	-0.2
Medication: Cholesterol lowering	0.8	1.2	2.0	-1.3	1.1	0.8	-1.4	-1.4	-1.3	-1.3	-1.4	-1.0	0.3	-0.4	-1.3	-0.7
Depression (self-reported)	0.1	0.1	0.8	0.3	-0.4	-0.1	0.3	0.3	0.4	0.3	-0.2	-0.3	-0.1	0.9	-0.0	-0.1
Medication: Lansoprazole	0.4	0.4	1.1	0.6	-0.8	-0.5	0.6	0.6	0.6	0.6	0.6	0.4	-0.5	0.0	-1.0	-1.1
Prospective memory result	0.4	0.5	1.4	0.6	0.4	-0.8	0.6	0.5	0.6	0.6	0.7	1.1	0.6	1.2	0.4	0.8
Lung cancer (father)	0.1	0.1	0.2	0.2	-0.4	-0.2	0.2	0.1	0.4	0.2	-0.1	0.4	-0.2	-0.4	-0.0	-0.0
Illnesses of mother	0.2	0.3	0.6	-0.6	0.2	0.7	-0.7	-0.7	-0.6	-0.7	-0.1	-0.6	-0.2	-0.4	0.5	-0.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.1	12.6	2.4	-3.6	-1.9	2.4	2.4	2.7	2.3	-0.6	1.5	2.4	2.3	3.2	3.1
Pulse wave Arterial Stiffness index	0.5	0.6	1.1	-0.8	0.6	0.1	-0.7	-0.8	-0.7	-0.9	0.9	-0.8	-1.0	-0.8	-0.7	-1.1
Impedance of arm (left)	0.9	4.2	25.4	1.8	-5.0	-2.2	2.0	1.7	2.9	1.7	0.4	0.6	-0.6	0.2	0.8	-1.0
Arm fat mass (right)	0.2	0.8	3.0	-0.4	0.5	-0.5	-0.4	-0.3	-0.6	-0.3	0.9	-0.4	1.7	1.0	1.5	1.5
Trunk predicted mass	2.2	12.7	25.1	3.5	-2.4	-4.0	3.5	3.6	3.3	3.5	1.5	2.8	3.9	3.7	5.0	4.3
Standing height	6.2	61.1	99.6	8.6	-10.0	-8.9	8.9	8.7	9.4	8.6	2.4	5.6	5.5	6.8	8.7	5.8
Length of working week for main job	1.0	1.1	4.0	-1.0	2.0	1.5	-1.2	-1.0	-1.1	-1.1	0.9	-0.4	-0.5	-0.7	-0.1	-0.1
Exposure to tobacco smoke at home	0.9	1.0	3.2	0.9	-0.5	-0.4	0.7	0.9	0.7	0.9	-0.9	1.0	1.8	1.5	0.8	1.0
Breastfed as a baby	0.2	0.3	1.3	-0.2	-0.5	0.2	-0.1	-0.2	-0.1	-0.1	-1.1	-0.9	-0.0	0.6	-0.2	-0.5
Tense / ‘highly strung’	1.6	2.7	5.5	-1.7	0.8	0.8	-1.7	-1.7	-1.6	-1.7	-0.7	-1.5	-2.0	-2.1	-2.3	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.4	-1.0	1.1	0.8	-0.9	-0.9	-1.2	-0.9	0.1	-0.7	-1.4	-1.6	-1.1	-1.0
Hair/balding pattern: Pattern 4	0.4	1.0	2.0	1.0	-1.4	-0.6	1.2	1.1	0.8	1.1	-0.9	0.3	-0.8	-0.1	-1.1	-1.4
Birth weight of first child	0.2	0.3	2.0	0.1	-0.2	-0.7	0.2	0.0	0.4	0.0	1.4	0.1	-0.8	-0.1	-0.2	-0.8
Peak expiratory flow (PEF)	2.1	4.9	6.8	-2.5	0.9	2.2	-2.5	-2.5	-2.4	-2.4	-2.0	-2.2	-1.9	-2.6	-2.4	-1.7
Pulse wave reflection index	0.5	0.6	2.0	-0.5	-0.2	0.5	-0.5	-0.5	-0.4	-0.6	-0.8	-0.5	-1.2	-1.0	-1.4	-1.1
Ever highly irritable/argumentative for 2 days	3.2	3.9	6.9	-2.0	1.6	1.6	-1.9	-1.9	-2.2	-2.0	-1.0	-2.0	-2.2	-2.0	-2.6	-2.0
Loud music exposure frequency	0.7	0.7	2.2	1.1	-0.2	-0.6	1.1	1.1	1.0	1.1	0.8	1.5	0.2	0.3	-0.1	0.1
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	1.5	-0.8	1.2	1.0	-0.9	-0.8	-1.0	-0.8	-0.8	-0.5	0.6	-0.0	0.5	0.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.8	0.0	0.5	-0.3	-0.1	0.1	-0.1	-0.1	0.7	0.9	0.5	-0.7	0.9	0.5
Blood clot in the leg (DVT)	0.7	0.9	2.8	1.0	-1.7	-1.1	1.1	1.0	1.2	1.1	0.7	0.7	-0.7	-0.2	0.1	-0.5
Medication: Paracetamol	0.4	0.6	1.5	0.7	-1.1	-1.2	0.9	0.7	1.0	0.7	-0.0	0.5	0.3	0.6	1.2	0.5
Headache pain in last month	0.8	1.3	3.2	-1.5	1.8	1.0	-1.4	-1.4	-1.6	-1.4	0.3	-1.0	0.2	-0.7	-0.5	0.3
Medication for cholesterol, blood pressure or diabetes	1.7	2.9	5.2	2.2	-0.7	-1.6	2.2	2.3	1.9	2.2	1.3	2.2	0.3	1.1	1.6	1.0
Glaucoma (self-reported)	1.0	1.1	2.0	1.2	0.4	-0.2	1.1	1.1	1.2	1.1	0.7	1.4	1.0	1.4	1.4	0.9
Gout (self-reported)	0.6	0.8	2.9	-0.2	1.4	0.4	-0.3	-0.2	-0.4	-0.2	0.7	0.2	1.6	0.5	1.5	1.7
Hypothyroidism/myxoedema (self-reported)	0.5	0.9	3.8	-0.8	1.0	1.1	-0.7	-0.9	-0.7	-0.8	2.0	-0.4	-0.8	-1.1	0.1	-0.8
Medication: Amlodipine	0.4	0.6	1.7	-0.6	-0.7	0.1	-0.7	-0.7	-0.1	-0.7	-1.0	-0.8	-0.3	-1.3	-0.8	-1.1
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.2	-1.0	0.7	1.0	-0.9	-0.9	-0.9	-0.9	0.9	-1.1	-0.8	-0.6	0.0	-0.3
Birth weight	0.2	0.5	1.7	0.1	-1.3	-0.4	0.1	0.1	0.5	0.1	0.1	-0.5	-1.3	-0.8	-0.8	-0.7
Chronic bronchitis/emphysema (mother)	0.7	0.8	1.9	-1.2	1.4	0.9	-1.1	-1.2	-1.1	-1.1	0.2	-0.7	0.5	0.2	0.1	0.4
High blood pressure (siblings)	0.5	0.7	1.3	1.0	-0.7	-0.9	1.0	1.0	1.1	0.9	0.2	1.0	0.3	1.1	-0.2	-0.4
Forced vital capacity (FVC), Best measure	9.3	34.2	53.0	6.3	-7.3	-5.7	6.4	6.4	6.8	6.3	0.6	4.2	4.8	5.8	7.0	5.6
Body fat percentage	0.1	0.5	0.9	-0.7	0.0	-0.6	-0.7	-0.7	-0.7	-0.7	0.9	-0.7	1.0	0.5	0.8	0.5
Leg fat percentage (right)	0.1	0.5	1.2	-1.0	0.5	-0.2	-1.0	-1.0	-1.1	-1.0	0.5	-0.9	0.5	-0.2	0.1	0.1
Arm fat-free mass (right)	1.7	8.6	17.5	2.7	-1.5	-2.9	2.7	2.9	2.4	2.8	1.1	2.1	3.8	3.5	4.2	4.0
Exposure to tobacco smoke outside home	0.2	0.3	1.2	0.1	-0.2	0.7	-0.0	0.0	0.2	0.1	0.6	0.1	-0.7	-0.8	-0.6	-1.1
Comparative body size at age 10	0.1	0.4	1.4	0.4	0.8	-0.1	0.3	0.4	0.1	0.3	0.4	1.0	0.3	0.6	1.2	0.7
Number of full brothers	3.0	3.8	6.7	-2.4	0.7	1.8	-2.1	-2.4	-2.1	-2.2	-1.1	-2.6	-2.1	-2.4	-1.1	-1.2
Worry too long after embarrassment	0.1	0.2	0.5	-0.4	0.3	-0.1	-0.4	-0.4	-0.7	-0.4	-0.4	-0.3	0.3	0.1	-0.6	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.3	1.7	4.0	-1.4	-0.1	1.2	-1.5	-1.4	-1.3	-1.5	-1.8	-2.0	-0.5	-0.6	-1.3	-1.1
Wheeze or whistling in the chest in last year	0.5	0.9	3.2	-0.0	1.2	-0.5	-0.0	-0.0	-0.2	0.0	1.4	-0.0	1.3	1.8	1.4	1.1
Number of children fathered	1.3	1.5	4.3	1.3	0.7	-0.5	1.3	1.4	0.9	1.4	1.5	1.1	0.9	2.1	0.8	1.0
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	2.4	-1.4	0.8	1.1	-1.4	-1.4	-1.2	-1.3	-0.7	-1.6	-0.5	-1.0	-1.4	-0.8
Age at first live birth	0.6	1.1	7.0	0.1	-1.1	-0.2	0.0	0.1	0.1	0.1	-2.7	-0.9	1.7	1.4	0.0	0.7
Pulse wave peak to peak time	1.2	1.5	2.1	1.3	-1.4	-0.6	1.2	1.3	1.2	1.3	-1.0	1.0	1.3	1.1	1.3	1.4
Health satisfaction	0.2	0.3	1.5	0.0	0.7	0.0	-0.1	-0.0	-0.1	-0.1	1.2	0.2	0.6	0.7	0.6	1.0
Shortness of breath walking on level ground	0.3	0.3	0.7	-0.5	0.8	0.8	-0.6	-0.5	-0.6	-0.5	0.7	-0.3	0.3	-0.0	0.8	0.2
Qualifications: College or University degree	0.7	2.4	3.8	-1.8	1.3	1.7	-1.7	-1.7	-1.9	-1.7	-0.8	-1.7	-1.0	-1.9	-1.1	-0.9
Eye problems/disorders: None of the above	1.1	1.3	3.4	-0.8	-0.5	0.2	-0.8	-0.8	-0.7	-0.8	-1.1	-1.3	-1.5	-1.3	-1.8	-1.6
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.6	-1.2	0.9	1.9	-1.2	-1.2	-1.3	-1.3	0.7	-1.0	-0.7	-1.1	-0.3	-0.4
Emphysema/chronic bronchitis	1.7	2.0	6.6	1.4	-0.5	-2.0	1.5	1.4	1.4	1.5	2.6	1.5	-0.4	-0.0	1.2	-0.4
Medication for pain relief, constipation, heartburn	0.8	1.4	2.9	1.6	-1.1	-0.9	1.5	1.6	1.6	1.6	0.5	1.7	0.3	0.7	0.2	0.2
Neck or shoulder pain in last month	0.2	0.2	1.4	0.2	1.2	-0.4	0.1	0.2	0.2	0.2	0.5	0.7	0.3	0.3	-0.5	-0.1
Medication: Blood pressure	1.6	2.8	4.8	-2.1	1.1	1.4	-2.2	-2.2	-1.9	-2.1	-1.4	-2.1	-0.1	-0.7	-1.8	-0.9
Angina (self-reported)	0.7	0.9	1.7	1.2	-0.5	-1.1	1.2	1.2	1.0	1.2	0.6	1.3	0.5	0.9	0.7	0.2
Migraine (self-reported)	1.0	1.3	5.2	-0.6	1.6	1.0	-0.7	-0.6	-0.9	-0.6	0.9	-0.1	1.4	0.3	1.6	2.3
Medication: Ibuprofen	1.2	1.5	2.8	-1.5	1.2	1.3	-1.5	-1.5	-1.7	-1.5	-0.4	-1.3	-0.7	-1.0	-1.0	-0.0
Medication: Allopurinol	0.5	0.7	2.1	0.3	1.2	0.2	0.2	0.3	0.1	0.3	0.4	0.6	1.5	1.0	1.4	1.3
Medication: Omeprazole	0.2	0.2	0.6	-0.3	0.8	0.4	-0.3	-0.3	-0.5	-0.3	0.8	-0.4	0.2	-0.2	-0.0	-0.6
Medication: Seretide 50 evohaler	0.3	0.4	0.9	0.5	-0.7	-0.6	0.6	0.5	0.6	0.5	0.7	0.4	-0.8	-0.6	0.9	-0.2
Mean time to correctly identify matches	0.4	0.7	1.2	-1.0	0.5	1.1	-0.9	-1.0	-0.9	-1.0	-0.6	-0.8	-0.6	-1.0	-0.8	-0.5
Heart disease (mother)	0.3	0.3	1.0	-0.2	-0.1	0.5	-0.3	-0.1	-0.2	-0.2	-1.0	-0.4	-0.8	-0.6	-0.9	-0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria	6.7	8.0	12.2	-3.5	2.5	3.4	-3.4	-3.5	-3.2	-3.5	-0.4	-3.1	-1.8	-2.5	-2.1	-1.9
Whole body fat mass	0.3	1.3	4.0	0.4	-0.6	-1.4	0.3	0.4	0.3	0.3	1.0	0.0	2.0	1.5	2.0	1.7
Leg fat mass (right)	0.2	0.9	3.0	0.1	-0.0	-1.0	0.1	0.1	-0.1	0.1	1.2	-0.0	1.7	1.2	1.6	1.4
Arm predicted mass (right)	1.9	9.8	18.1	3.0	-1.6	-3.1	2.9	3.1	2.7	3.0	1.1	2.3	4.0	3.8	4.3	4.1
Pulse rate, automated reading	0.8	2.5	7.3	-1.7	2.7	1.3	-1.7	-1.6	-1.9	-1.6	1.0	-1.6	-0.9	-1.1	-1.4	-1.2
Alcohol intake frequency.	0.1	0.3	2.2	0.1	0.3	0.4	0.1	0.0	-0.0	0.0	1.5	0.3	-0.4	0.2	-0.7	-0.6
Comparative height size at age 10	6.7	36.9	51.7	6.8	-6.5	-6.5	6.9	6.8	7.0	6.7	1.7	4.9	4.9	5.7	7.2	5.0
Number of full sisters	1.9	2.3	7.5	1.3	0.2	-0.3	1.2	1.2	1.1	1.2	-0.2	1.5	1.8	2.7	1.8	2.4
Suffer from ‘nerves’	0.4	0.6	2.1	0.3	-0.6	-1.0	0.5	0.3	0.6	0.4	1.0	0.4	-1.4	-0.7	-0.6	-1.3
Overall health rating	0.6	1.3	2.9	1.0	1.4	-0.7	0.9	0.9	0.6	1.0	1.7	1.7	0.8	1.1	1.2	1.2
Chest pain or discomfort	0.2	0.3	1.4	-0.4	0.3	0.8	-0.3	-0.4	-0.5	-0.4	-0.6	-0.4	-0.5	-1.2	0.1	-0.3
Had major operations	2.4	2.8	5.2	2.0	-1.3	-2.3	2.1	2.0	1.9	2.0	1.3	1.6	0.8	1.9	1.0	0.2
Age at last live birth	2.0	2.8	10.4	1.1	-0.8	-0.7	0.9	1.1	0.9	1.1	-1.7	0.3	3.2	2.4	2.3	2.5
Family relationship satisfaction	0.3	0.3	1.6	-0.4	0.4	1.3	-0.4	-0.4	-0.4	-0.4	-0.9	-0.6	-0.7	-0.0	0.0	0.3
Leg pain on walking	0.5	0.6	2.7	-0.6	1.6	0.8	-0.6	-0.5	-0.9	-0.5	1.5	-0.3	0.4	0.1	0.1	-0.3
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	3.1	-0.3	0.3	0.1	-0.4	-0.3	-0.5	-0.3	-1.8	-0.3	-0.3	-0.5	-0.0	0.2
Commuting to job workplace: Car/motor vehicle	0.8	1.0	3.3	1.1	-0.5	-1.8	1.2	1.2	1.0	1.1	0.5	1.2	-0.1	0.6	0.9	0.1
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.5	-0.4	-1.3	0.8	-0.3	-0.4	-0.2	-0.3	-1.6	-0.6	-0.9	-1.4	-0.7	-1.0
Medication: Aspirin	1.8	2.4	3.9	-1.9	1.9	1.8	-1.9	-2.0	-1.8	-1.9	0.4	-1.5	-0.4	-1.1	-1.3	-0.6
Supplements: Vitamin C	0.2	0.3	0.5	-0.7	0.5	0.1	-0.6	-0.7	-0.6	-0.7	0.4	-0.2	-0.5	-0.7	-0.2	-0.4
Knee pain experienced in last month	0.2	0.3	0.8	0.4	-0.7	-0.9	0.6	0.4	0.7	0.4	0.4	0.6	-0.5	-0.4	0.6	-0.1
Hypertension (Self-reported)	0.1	0.2	1.0	-0.0	-0.3	-0.0	-0.1	-0.1	0.3	-0.1	0.3	0.1	1.0	0.1	0.8	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.9	-0.5	0.5	1.0	-0.6	-0.4	-0.7	-0.4	0.2	-0.8	-0.3	-0.6	-0.8	-0.5
Illnesses of father: Heart disease	1.2	1.7	3.0	-1.3	0.9	1.6	-1.2	-1.2	-1.7	-1.2	-1.7	-1.7	-0.8	-0.7	-1.6	-0.8
Illnesses of siblings: Diabetes	0.7	0.9	5.4	0.5	-2.3	-0.6	0.6	0.5	0.7	0.5	-1.9	-0.3	0.3	0.1	0.8	0.4
Smoking status: Previous	0.3	0.4	1.3	0.3	-0.9	-0.5	0.5	0.3	0.5	0.4	-0.1	-0.0	-1.1	-0.8	-0.6	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	4.2	8.6	14.2	3.4	-3.8	-2.8	3.5	3.5	3.6	3.4	1.2	2.2	1.8	1.9	3.4	2.4
Whole body fat-free mass	1.9	10.7	22.5	3.1	-2.0	-3.5	3.1	3.2	2.8	3.1	1.3	2.4	3.9	3.5	4.7	4.2
Leg fat-free mass (right)	1.5	8.1	19.0	2.5	-1.1	-2.7	2.5	2.6	2.1	2.5	1.5	2.1	3.8	3.3	4.4	4.0
Arm fat percentage (left)	0.3	1.3	2.6	-1.5	1.2	0.5	-1.5	-1.5	-1.6	-1.5	1.1	-1.1	0.7	-0.1	0.3	0.3
Average weekly red wine intake	0.3	0.5	2.7	0.5	-1.7	-0.9	0.7	0.5	0.8	0.5	-0.4	0.0	-0.3	-0.2	0.2	-0.4
Handedness (chirality/laterality): Left-handed	0.4	0.5	2.7	0.6	1.2	-0.5	0.6	0.6	0.3	0.5	1.6	0.6	-0.2	0.5	-0.2	-0.3
Mood swings	0.1	0.1	0.4	0.6	-0.1	0.2	0.5	0.6	0.3	0.6	0.1	0.4	-0.2	0.1	0.1	0.2
Loneliness, isolation	3.2	4.5	10.4	-1.7	1.9	1.6	-1.4	-1.6	-2.0	-1.6	-0.3	-1.5	-3.2	-2.5	-3.1	-3.0
Long-standing illness, disability or infirmity	0.1	0.1	0.8	-0.3	0.2	0.0	-0.3	-0.4	-0.1	-0.3	0.9	-0.2	0.1	0.0	0.3	0.1
Ever had bowel cancer screening	3.9	4.6	7.1	2.5	-2.3	-2.7	2.6	2.5	2.6	2.6	1.4	2.5	1.0	1.1	2.1	0.5
Diabetes diagnosed by doctor	0.1	0.2	1.3	-0.2	0.2	-0.1	-0.4	-0.3	-0.1	-0.3	1.1	0.1	0.8	0.6	0.2	0.5
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.5	2.9	1.4	-0.0	-1.7	1.4	1.5	1.1	1.5	0.6	1.6	0.7	1.3	1.0	1.1
Friendships satisfaction	1.9	2.3	5.2	-1.6	1.0	2.3	-1.7	-1.7	-1.7	-1.8	-0.8	-1.7	-1.3	-1.0	-1.6	-0.9
Qualifications: nursing, teaching	0.7	1.2	2.5	-1.3	0.2	1.2	-1.3	-1.3	-1.4	-1.3	-0.4	-1.3	-0.7	-1.6	-0.1	0.1
Commuting to job workplace: Walk	0.4	0.4	1.4	-0.6	-0.6	0.6	-0.7	-0.7	-0.3	-0.8	-1.2	-0.7	-0.4	-0.7	-0.5	-0.3
Eye problems/disorders: Cataract	0.1	0.1	0.2	0.2	-0.3	0.4	0.2	0.1	0.2	0.1	0.0	0.2	0.4	0.0	0.5	0.2
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	4.3	1.6	-1.7	-0.7	1.7	1.6	2.1	1.7	1.9	1.8	-1.3	-0.2	0.1	-0.9
Medication for cholesterol	0.7	1.1	3.3	-0.9	1.2	0.5	-0.9	-0.9	-1.3	-0.9	-1.2	-0.8	-0.8	-0.5	-1.8	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	3.6	1.5	-1.2	-1.9	1.5	1.4	1.3	1.4	-1.7	0.8	0.7	1.7	1.1	0.8
Back pain experienced in last month	1.3	1.8	5.0	1.3	-0.4	-0.6	1.4	1.3	1.1	1.3	1.5	1.5	-2.2	-1.2	-1.0	-1.7
Mineral and other dietary supplements	0.6	0.8	3.2	0.4	-0.7	-0.4	0.3	0.4	0.5	0.4	-0.2	0.0	1.6	1.1	1.4	1.8
Breast cancer (self-reported)	0.2	0.3	0.9	0.4	-0.5	-0.4	0.4	0.5	0.1	0.5	-0.8	0.4	-0.5	-0.4	-1.0	-0.6
Asthma (self-reported)	1.4	2.8	12.9	0.8	-0.3	-0.7	0.9	0.8	0.9	0.8	1.7	0.8	2.2	2.0	3.6	2.7
Osteoporosis (self-reported)	1.1	1.3	3.1	1.0	-1.1	-1.0	0.7	0.9	0.9	0.8	-1.6	0.7	1.6	1.8	-0.1	1.6
Osteoarthritis (self-reported)	1.0	1.3	2.6	1.3	-1.6	-1.6	1.4	1.3	1.1	1.3	0.0	1.2	0.3	-0.4	1.0	0.5
Medication: Aspirin	1.7	2.3	3.4	-1.8	1.8	1.6	-1.8	-1.8	-1.8	-1.8	0.4	-1.3	-0.6	-1.3	-1.4	-0.9
Medication: Gliclazide	0.6	0.7	1.7	-0.7	1.3	0.6	-0.8	-0.7	-0.8	-0.7	0.9	-0.2	1.1	0.2	1.1	1.1
Illnesses of father: None of the above (group 1)	1.1	1.4	2.6	1.5	-1.5	-1.2	1.5	1.4	1.6	1.4	0.5	1.5	-0.1	0.3	0.9	0.3
Smoking status: Current	0.5	0.9	3.8	0.8	1.1	-0.5	0.6	0.7	0.7	0.8	0.5	0.8	1.0	1.9	0.9	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	3.7	-0.2	-1.6	0.1	-0.2	-0.2	0.2	-0.2	-1.9	-0.7	0.7	0.7	0.5	1.3
Whole body water mass	1.8	10.3	21.4	3.0	-1.9	-3.3	3.0	3.1	2.7	3.1	1.2	2.4	3.9	3.5	4.6	4.2
Leg predicted mass (right)	1.5	7.8	18.6	2.4	-1.1	-2.7	2.4	2.5	2.0	2.5	1.4	2.0	3.7	3.2	4.3	4.0
Arm fat mass (left)	0.2	0.9	3.0	-0.3	0.6	-0.5	-0.4	-0.3	-0.6	-0.4	1.1	-0.3	1.7	1.1	1.4	1.5
Number of self-reported non-cancer illnesses	0.2	0.4	1.4	0.2	-0.6	-0.4	0.2	0.1	0.4	0.1	0.6	0.2	1.2	0.3	1.1	0.9
Average weekly champagne plus white wine intake	0.3	0.4	3.5	-0.4	-0.0	-0.4	-0.3	-0.3	-0.6	-0.4	0.2	-0.1	-0.9	-1.9	0.0	-0.3
Miserableness	0.9	1.6	3.6	1.7	-0.7	-1.4	1.8	1.9	1.1	1.9	-0.5	1.5	0.1	0.9	-0.7	0.4
Guilty feelings	0.8	1.3	3.8	-0.9	0.9	0.9	-0.9	-0.9	-1.2	-0.9	-0.3	-0.5	-1.5	-1.3	-1.9	-1.5
Wears glasses or contact lenses	0.2	0.2	1.0	-0.2	1.0	0.3	-0.0	-0.1	-0.4	-0.1	1.0	-0.3	0.3	0.6	0.2	-0.5
Ever taken oral contraceptive pill	0.9	1.0	2.1	-1.1	1.4	0.5	-1.2	-1.1	-1.1	-1.2	-0.4	-0.7	-1.1	-0.8	-1.4	-0.7
Hearing aid user	0.5	0.5	1.1	-1.0	0.5	0.7	-1.0	-1.0	-0.7	-1.0	0.1	-1.1	-0.2	-0.6	0.1	-0.5
Mother’s age at death	0.2	0.3	1.3	-0.1	-0.1	-0.2	-0.1	-0.0	-0.2	-0.1	-1.0	-0.9	0.4	1.2	-0.7	0.3
Financial situation satisfaction	0.9	1.1	3.2	-0.0	1.5	0.2	-0.2	-0.1	-0.3	-0.1	1.1	0.5	1.8	1.8	1.4	1.6
Tinnitus: Yes, now most or all of the time	1.6	1.9	3.8	-1.5	0.2	1.6	-1.5	-1.5	-1.3	-1.4	-1.5	-1.5	-0.2	-1.1	-1.9	-1.5
Commuting to job workplace: Public transport	1.2	1.4	4.4	1.0	-0.3	-0.8	0.9	1.0	0.7	1.0	-0.1	1.1	1.9	1.2	1.7	2.1
Eye problems/disorders: Glaucoma	0.6	0.8	1.7	1.0	0.7	0.0	0.9	1.0	0.8	0.9	0.6	1.3	0.6	1.2	0.9	0.6
Medication: Blood pressure	0.9	1.7	3.4	1.2	-1.1	-1.3	1.2	1.2	1.4	1.2	1.6	1.3	0.9	0.6	1.8	1.4
Pain type(s) experienced in last month: Hip pain	2.6	3.3	9.8	2.0	-0.4	-2.1	2.1	2.1	1.9	2.0	3.1	2.0	-1.3	0.4	-0.1	-1.3
Supplements: Fish oil (including cod liver oil)	0.9	1.2	4.8	-0.2	-0.5	0.7	0.0	-0.2	-0.2	-0.1	0.0	-0.1	-2.1	-1.9	-1.5	-2.2
High cholesterol (Self-reported)	0.2	0.4	3.9	0.3	-2.0	0.0	0.2	0.2	0.8	0.1	-0.3	-0.1	-0.4	-0.4	0.1	-0.3
Medication: Bendroflumethiazide	0.3	0.4	2.4	-0.4	-0.0	0.1	-0.6	-0.4	-0.5	-0.4	-0.4	-0.4	1.5	0.8	0.3	1.0
Medication: Paracetamol	0.7	1.1	2.8	0.9	-1.7	-1.3	1.0	0.8	1.3	0.8	-0.4	0.7	0.8	0.7	1.6	1.0
Medication: Lisinopril	0.2	0.3	1.5	0.2	-0.9	-0.7	0.2	0.2	0.2	0.2	0.2	0.3	0.9	0.2	0.5	1.2
Medication: Atorvastatin	0.9	1.1	2.3	-1.3	0.4	1.2	-1.3	-1.3	-1.2	-1.3	-1.3	-1.5	-0.2	-0.7	-0.2	-0.3
Illnesses of father: High blood pressure	0.2	0.3	1.2	0.3	-0.6	-0.4	0.2	0.3	0.4	0.3	0.5	0.3	0.8	0.5	0.8	1.1
Alcohol drinker status: Never	0.4	0.5	1.0	-0.9	0.1	0.4	-0.9	-1.0	-1.0	-0.9	-0.4	-1.0	0.1	-0.6	-0.6	-0.5
Ever smoked	0.5	0.9	2.4	-0.1	-0.7	0.2	-0.1	-0.1	0.0	-0.0	-1.5	-0.8	-1.6	-1.4	-1.1	-1.6
Basal metabolic rate	1.7	9.4	21.3	2.8	-1.8	-3.2	2.8	2.9	2.5	2.8	1.3	2.1	3.8	3.4	4.6	4.2
Leg fat percentage (left)	0.2	0.6	1.3	-1.0	0.9	-0.2	-1.0	-1.0	-1.1	-1.0	0.9	-0.8	0.4	-0.0	0.1	0.1
Arm fat-free mass (left)	1.6	8.0	16.2	2.7	-1.4	-3.0	2.6	2.8	2.3	2.7	0.8	2.0	3.5	3.2	4.0	3.9
Number of operations (self-reported)	0.1	0.2	0.5	0.2	-0.6	-0.6	0.3	0.1	0.2	0.2	0.2	0.3	-0.7	-0.3	-0.1	-0.7
Average weekly beer plus cider intake	1.0	1.4	5.2	0.8	-0.5	-0.3	0.7	0.8	1.0	0.9	-1.1	1.0	1.5	1.1	1.8	2.3
Irritability	2.2	3.7	5.3	-2.2	1.1	1.6	-2.1	-2.1	-2.3	-2.1	-1.9	-2.3	-1.9	-2.2	-1.9	-0.9
Risk taking	0.8	1.2	6.3	-0.3	-0.3	-0.7	-0.3	-0.4	0.0	-0.4	0.0	-0.3	-2.5	-1.9	-0.7	-1.9
Ever had prostate specific antigen (PSA) test	0.2	0.3	1.5	-0.1	-0.5	-0.4	-0.0	-0.1	-0.2	-0.1	-1.2	-0.6	0.5	0.3	0.6	0.7
Fractured/broken bones in last 5 years	0.8	1.0	3.8	-0.9	0.5	0.8	-0.8	-0.9	-0.8	-0.9	0.2	-0.2	-1.6	-1.9	-0.8	-1.0
Age started oral contraceptive pill	0.3	0.4	1.3	-0.2	-1.1	0.6	-0.2	-0.3	0.2	-0.2	1.0	-0.9	-0.7	-0.5	-0.3	-0.9
Diastolic blood pressure, automated reading	0.6	2.0	7.0	0.9	-1.0	-0.7	0.9	0.9	0.9	0.8	0.0	0.6	2.6	1.7	2.3	2.2
Ever depressed for a whole week	0.7	0.8	3.4	-0.4	1.5	1.0	-0.4	-0.3	-1.0	-0.4	0.2	-0.2	-1.2	-0.5	-1.9	-0.9
Unable to work because of sickness or disability	0.2	0.3	2.1	-0.2	1.4	-0.5	-0.3	-0.3	-0.4	-0.3	0.8	0.2	0.4	0.4	-0.3	-0.1
Commuting to job workplace: Cycle	1.1	1.3	3.6	-0.9	-0.8	0.9	-0.9	-0.9	-0.6	-0.8	-1.0	-1.3	1.9	0.9	1.3	1.8
Myopia	0.2	0.3	1.8	-0.4	1.4	0.7	-0.4	-0.3	-0.5	-0.3	0.3	-0.4	0.1	0.7	-0.4	0.2
Vascular/heart problems diagnosed by doctor	0.1	0.2	1.1	0.0	0.3	0.2	0.1	0.1	-0.2	0.1	-0.1	-0.2	-1.1	0.0	-0.8	-0.7
Cholesterol lowering medication	2.1	3.2	5.5	2.1	-2.3	-1.5	2.0	2.1	2.3	2.0	1.3	1.6	0.5	1.1	2.0	1.0
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.5	-0.4	0.5	0.4	-0.5	-0.4	-0.5	-0.4	0.7	-0.7	0.5	-0.1	0.3	-0.3
Pain experienced in last month	0.5	0.8	1.9	-0.7	-0.1	1.0	-0.9	-0.7	-0.6	-0.7	-1.1	-0.8	1.2	0.7	0.9	1.4
Supplements: Calcium	0.3	0.4	1.5	-0.4	-0.2	1.0	-0.5	-0.5	-0.3	-0.6	-0.5	-0.4	-0.5	-0.1	-1.2	-0.6
Basal cell carcinoma (self-reported)	0.4	0.5	2.0	-0.5	1.0	-0.2	-0.4	-0.5	-0.9	-0.3	-1.4	-0.3	-0.2	-0.6	-0.9	-0.5
Heart attack/myocardial infarction (self-reported)	1.1	1.4	2.8	1.4	-0.1	-0.8	1.5	1.4	1.1	1.5	0.3	1.4	0.9	1.7	1.1	1.0
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.8	0.8	-1.7	-0.9	0.9	0.8	1.1	0.9	0.8	0.5	-0.8	-0.4	0.1	-0.6
Heart disease (siblings)	0.6	0.7	2.3	0.5	-0.8	-1.5	0.6	0.5	1.1	0.4	0.8	0.7	-0.8	-0.3	1.4	0.4
Alcohol drinker status: Previous	0.4	0.5	1.5	-0.6	-0.3	1.2	-0.6	-0.6	-0.7	-0.6	-1.2	-1.1	0.3	-0.5	0.1	0.2
Pack years of smoking	0.9	1.3	2.4	0.8	1.3	-0.9	0.7	0.8	0.4	0.8	1.4	1.1	1.5	1.6	1.4	1.3
Impedance of whole body	1.1	5.7	28.6	2.3	-5.3	-2.7	2.6	2.2	3.4	2.2	0.2	1.0	-1.0	0.3	0.4	-1.3
Leg fat mass (left)	0.3	1.1	3.1	0.3	0.0	-1.0	0.3	0.4	0.1	0.3	1.4	0.2	1.8	1.4	1.7	1.5
Arm predicted mass (left)	1.8	9.3	19.4	2.8	-1.4	-3.0	2.7	2.9	2.4	2.8	0.9	2.0	4.1	3.6	4.4	4.3