Best TWAS P=6.61e-24 · Best GWAS P=1.1e-25 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Cerebellar Hemisphere | DCST2 | 0.45 | 0.10 | lasso | 6 | 0.16 | 6.6e-05 | 4.61 | -8.7 | 2.7e-18 | 0.14 | 0.07 | 0.74 | FALSE |
2 | GTEx | Brain Nucleus accumbens basal ganglia | DCST2 | 0.28 | 0.04 | lasso | 5 | 0.13 | 2.0e-04 | -10.06 | -8.5 | 1.8e-17 | 0.19 | 0.10 | 0.38 | FALSE |
3 | GTEx | Brain Putamen basal ganglia | DCST2 | 0.56 | 0.05 | enet | 11 | 0.10 | 2.8e-03 | 4.61 | -5.5 | 3.6e-08 | 0.15 | 0.32 | 0.23 | TRUE |
4 | GTEx | Esophagus Mucosa | MUC1 | 0.17 | 0.20 | lasso | 4 | 0.18 | 5.6e-12 | 6.09 | 5.5 | 4.7e-08 | -0.28 | 1.00 | 0.00 | TRUE |
5 | GTEx | Pituitary | KCNN3 | 0.41 | 0.31 | lasso | 6 | 0.28 | 7.4e-08 | 4.93 | 5.4 | 6.1e-08 | -0.10 | 0.89 | 0.02 | TRUE |
6 | GTEx | Skin Sun Exposed Lower leg | ADAM15 | 0.14 | 0.09 | lasso | 4 | 0.08 | 6.1e-07 | -10.06 | 10.0 | 1.7e-23 | -0.08 | 0.04 | 0.96 | FALSE |
7 | GTEx | Thyroid | DCST2 | 0.16 | 0.12 | lasso | 2 | 0.11 | 6.4e-09 | 4.61 | -6.1 | 1.1e-09 | 0.14 | 0.96 | 0.04 | FALSE |
8 | GTEx | Whole Blood | ADAM15 | 0.10 | 0.00 | lasso | 13 | 0.00 | 1.5e-01 | 5.39 | 5.9 | 3.8e-09 | -0.22 | 0.14 | 0.40 | FALSE |
9 | GTEx | Whole Blood | C1orf43 | 0.10 | 0.00 | enet | 37 | 0.00 | 2.8e-01 | 2.95 | 5.6 | 2.7e-08 | -0.05 | 0.02 | 0.70 | TRUE |
10 | NTR | Blood | ZBTB7B | 0.02 | 0.02 | lasso | 1 | 0.01 | 5.4e-05 | -5.95 | -6.0 | 2.6e-09 | -0.01 | 0.89 | 0.00 | FALSE |
11 | YFS | Blood | GBA | 0.04 | 0.01 | bslmm | 321 | 0.02 | 3.9e-08 | -3.81 | -5.2 | 2.5e-07 | 0.38 | 0.98 | 0.00 | FALSE |
12 | The Cancer Genome Atlas | Colon Adenocarcinoma | ADAM15 | 0.15 | 0.02 | blup | 49 | 0.08 | 1.4e-05 | -10.31 | 7.8 | 4.1e-15 | -0.29 | 0.00 | 0.86 | TRUE |
13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MUC1 | 0.04 | 0.01 | enet | 4 | 0.02 | 1.3e-03 | 6.09 | 5.3 | 8.6e-08 | -0.18 | 0.04 | 0.03 | FALSE |
14 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | THBS3 | 0.04 | 0.01 | blup | 25 | 0.03 | 3.1e-04 | -1.54 | -5.2 | 1.6e-07 | 0.64 | 0.05 | 0.53 | FALSE |
15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PBXIP1 | 0.06 | 0.06 | enet | 5 | 0.06 | 4.0e-07 | 4.89 | -5.5 | 3.7e-08 | 0.16 | 0.01 | 0.99 | TRUE |
16 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ADAM15 | 0.09 | 0.00 | blup | 49 | 0.02 | 3.6e-02 | 3.50 | 8.2 | 2.7e-16 | -0.24 | 0.01 | 0.11 | FALSE |
17 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | THBS3 | 0.04 | 0.02 | enet | 8 | 0.01 | 4.5e-02 | -1.57 | -5.5 | 3.2e-08 | 0.51 | 0.02 | 0.32 | FALSE |
18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADAM15 | 0.07 | 0.00 | enet | 12 | 0.04 | 6.1e-05 | -10.31 | 5.4 | 8.1e-08 | -0.19 | 0.01 | 0.86 | FALSE |
19 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ZBTB7B | 0.05 | 0.06 | lasso | 2 | 0.05 | 1.8e-06 | -10.06 | 10.1 | 6.6e-24 | -0.07 | 0.01 | 0.99 | TRUE |
20 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | AQP10 | 0.12 | 0.01 | blup | 37 | 0.04 | 7.1e-03 | 2.68 | -5.2 | 2.3e-07 | -0.02 | 0.00 | 0.54 | FALSE |
21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GBA | 0.05 | 0.01 | lasso | 2 | 0.01 | 2.3e-02 | -10.48 | 10.0 | 1.3e-23 | -0.93 | 0.00 | 0.87 | TRUE |
22 | The Cancer Genome Atlas | Thyroid Carcinoma | THBS3 | 0.14 | 0.03 | enet | 16 | 0.08 | 3.8e-08 | 0.42 | -5.7 | 1.3e-08 | 0.69 | 0.00 | 0.99 | TRUE |