Best TWAS P=1.94e-50 · Best GWAS P=1.75e-72 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | PSMB4 | 0.09 | 0.07 | lasso | 1 | 0.06 | 4.8e-08 | -5.4 | -5.4 | 8.2e-08 | -0.02 | 0.97 | 0.03 | FALSE |
2 | GTEx | Adipose Subcutaneous | MTMR11 | 0.08 | 0.04 | lasso | 4 | 0.05 | 3.5e-05 | -10.4 | -11.4 | 5.3e-30 | -0.37 | 0.78 | 0.03 | FALSE |
3 | GTEx | Adipose Subcutaneous | POGZ | 0.08 | 0.05 | lasso | 5 | 0.04 | 3.4e-04 | -5.4 | -5.4 | 7.1e-08 | -0.02 | 0.40 | 0.04 | FALSE |
4 | GTEx | Adipose Subcutaneous | RP11-196G18.22 | 0.13 | 0.02 | enet | 16 | 0.06 | 6.4e-06 | 1.7 | 5.3 | 1.1e-07 | 0.44 | 0.10 | 0.15 | TRUE |
5 | GTEx | Adipose Visceral Omentum | POGZ | 0.12 | 0.04 | enet | 14 | 0.04 | 2.6e-03 | -5.4 | -5.3 | 1.0e-07 | -0.05 | 0.67 | 0.08 | FALSE |
6 | GTEx | Adrenal Gland | CTSS | 0.12 | 0.13 | lasso | 9 | 0.08 | 7.0e-04 | -6.0 | -5.6 | 2.1e-08 | 0.00 | 0.62 | 0.20 | FALSE |
7 | GTEx | Artery Aorta | RPRD2 | 0.08 | -0.01 | enet | 19 | 0.00 | 4.2e-01 | -4.3 | 9.1 | 9.3e-20 | 0.30 | 0.08 | 0.26 | FALSE |
8 | GTEx | Artery Tibial | ARNT | 0.09 | 0.07 | lasso | 3 | 0.06 | 1.5e-05 | 5.5 | -5.6 | 2.6e-08 | -0.07 | 0.11 | 0.85 | FALSE |
9 | GTEx | Artery Tibial | POGZ | 0.15 | 0.13 | lasso | 5 | 0.10 | 4.6e-08 | -5.2 | -5.3 | 1.1e-07 | -0.03 | 0.98 | 0.02 | FALSE |
10 | GTEx | Artery Tibial | HIST2H2AA3 | 0.22 | 0.02 | enet | 20 | 0.12 | 1.8e-09 | 16.8 | 14.3 | 1.7e-46 | 0.70 | 0.00 | 1.00 | FALSE |
11 | GTEx | Artery Tibial | RP11-196G18.22 | 0.25 | 0.05 | lasso | 5 | 0.07 | 1.8e-06 | 11.4 | 14.9 | 1.9e-50 | 0.78 | 0.01 | 0.98 | TRUE |
12 | GTEx | Artery Tibial | RP11-196G18.24 | 0.31 | 0.08 | enet | 26 | 0.10 | 6.1e-08 | 16.8 | 12.6 | 1.3e-36 | 0.72 | 0.00 | 0.99 | FALSE |
13 | GTEx | Brain Cerebellar Hemisphere | RP11-316M1.12 | 0.31 | 0.37 | lasso | 4 | 0.39 | 4.5e-11 | -4.2 | 5.4 | 5.8e-08 | 0.01 | 0.98 | 0.02 | FALSE |
14 | GTEx | Brain Hippocampus | ARNT | 0.14 | 0.09 | enet | 14 | 0.08 | 5.3e-03 | -3.5 | -5.6 | 2.6e-08 | 0.00 | 0.10 | 0.08 | FALSE |
15 | GTEx | Brain Hypothalamus | RP11-316M1.12 | 0.14 | 0.03 | lasso | 6 | 0.02 | 9.9e-02 | -5.2 | 5.4 | 6.3e-08 | 0.09 | 0.11 | 0.09 | FALSE |
16 | GTEx | Cells EBV-transformed lymphocytes | CDC42SE1 | 0.39 | 0.09 | lasso | 7 | 0.05 | 7.9e-03 | -4.8 | -5.3 | 1.5e-07 | 0.09 | 0.09 | 0.06 | FALSE |
17 | GTEx | Cells Transformed fibroblasts | POGZ | 0.16 | 0.12 | lasso | 5 | 0.12 | 4.1e-09 | -5.4 | -5.3 | 1.3e-07 | -0.01 | 0.98 | 0.02 | FALSE |
18 | GTEx | Cells Transformed fibroblasts | PSMB4 | 0.14 | 0.06 | lasso | 5 | 0.03 | 1.2e-03 | -5.4 | 5.3 | 1.4e-07 | 0.04 | 0.93 | 0.03 | FALSE |
19 | GTEx | Colon Transverse | SV2A | 0.09 | 0.00 | lasso | 9 | 0.00 | 2.2e-01 | -3.8 | 5.2 | 1.9e-07 | 0.22 | 0.05 | 0.12 | FALSE |
20 | GTEx | Esophagus Gastroesophageal Junction | RP11-316M1.12 | 0.25 | 0.40 | lasso | 8 | 0.41 | 4.4e-16 | -4.2 | 5.1 | 2.8e-07 | 0.01 | 1.00 | 0.00 | FALSE |
21 | GTEx | Esophagus Mucosa | C1orf56 | 0.07 | 0.06 | enet | 7 | 0.06 | 5.1e-05 | -5.0 | 5.1 | 2.9e-07 | -0.07 | 0.76 | 0.02 | FALSE |
22 | GTEx | Esophagus Muscularis | BOLA1 | 0.07 | 0.00 | lasso | 4 | 0.00 | 2.5e-01 | -10.8 | 12.3 | 9.6e-35 | 0.43 | 0.03 | 0.13 | FALSE |
23 | GTEx | Heart Left Ventricle | MTMR11 | 0.11 | 0.05 | lasso | 3 | 0.05 | 9.3e-04 | -10.8 | -9.6 | 9.9e-22 | -0.39 | 0.20 | 0.13 | TRUE |
24 | GTEx | Heart Left Ventricle | CERS2 | 0.08 | 0.02 | enet | 9 | 0.03 | 1.7e-02 | -4.2 | 5.8 | 5.2e-09 | 0.08 | 0.17 | 0.19 | FALSE |
25 | GTEx | Liver | RP11-316M1.12 | 0.27 | 0.33 | lasso | 5 | 0.37 | 2.9e-11 | -4.2 | 5.1 | 2.7e-07 | 0.00 | 0.99 | 0.01 | FALSE |
26 | GTEx | Lung | MTMR11 | 0.08 | 0.04 | lasso | 8 | 0.03 | 3.0e-03 | -10.4 | -10.1 | 5.0e-24 | -0.29 | 0.19 | 0.11 | TRUE |
27 | GTEx | Muscle Skeletal | CTSS | 0.04 | 0.01 | enet | 13 | 0.03 | 1.4e-03 | -5.3 | -5.5 | 4.3e-08 | -0.01 | 0.47 | 0.08 | FALSE |
28 | GTEx | Nerve Tibial | POGZ | 0.18 | 0.16 | lasso | 2 | 0.15 | 1.6e-10 | -5.3 | -5.3 | 1.1e-07 | -0.02 | 0.98 | 0.02 | FALSE |
29 | GTEx | Skin Not Sun Exposed Suprapubic | POGZ | 0.09 | 0.09 | lasso | 3 | 0.06 | 3.1e-04 | -5.2 | -5.2 | 2.0e-07 | -0.03 | 0.57 | 0.04 | FALSE |
30 | GTEx | Skin Sun Exposed Lower leg | MTMR11 | 0.03 | 0.01 | lasso | 5 | 0.00 | 1.2e-01 | -10.8 | -8.5 | 2.7e-17 | -0.39 | 0.05 | 0.05 | FALSE |
31 | GTEx | Skin Sun Exposed Lower leg | GABPB2 | 0.12 | 0.01 | enet | 16 | 0.04 | 1.8e-04 | 6.7 | -6.4 | 1.5e-10 | -0.03 | 0.06 | 0.60 | TRUE |
32 | GTEx | Skin Sun Exposed Lower leg | SV2A | 0.07 | 0.00 | enet | 15 | 0.02 | 6.0e-03 | -3.1 | -6.2 | 6.2e-10 | -0.16 | 0.07 | 0.12 | FALSE |
33 | GTEx | Spleen | RP11-54A4.2 | 0.29 | 0.10 | lasso | 9 | 0.04 | 3.8e-02 | -6.0 | 6.2 | 8.0e-10 | 0.04 | 0.31 | 0.04 | FALSE |
34 | GTEx | Stomach | CTSS | 0.05 | 0.02 | enet | 16 | 0.00 | 2.8e-01 | -4.2 | -5.6 | 2.4e-08 | -0.01 | 0.14 | 0.43 | FALSE |
35 | GTEx | Testis | CTSK | 0.07 | 0.01 | enet | 19 | 0.01 | 1.2e-01 | -4.1 | -5.2 | 2.4e-07 | -0.03 | 0.28 | 0.27 | FALSE |
36 | GTEx | Testis | POGZ | 0.22 | 0.18 | enet | 11 | 0.16 | 1.1e-07 | -5.4 | -5.2 | 2.1e-07 | -0.02 | 0.98 | 0.02 | FALSE |
37 | GTEx | Thyroid | MTMR11 | 0.09 | 0.05 | enet | 9 | 0.06 | 1.5e-05 | -10.8 | -9.7 | 3.7e-22 | -0.40 | 0.26 | 0.42 | FALSE |
38 | GTEx | Thyroid | PRUNE | 0.11 | 0.00 | enet | 21 | 0.03 | 3.1e-03 | -2.1 | -6.5 | 7.9e-11 | -0.07 | 0.42 | 0.04 | FALSE |
39 | GTEx | Thyroid | ANP32E | 0.08 | 0.00 | enet | 15 | 0.01 | 8.6e-02 | -6.9 | 11.2 | 6.7e-29 | 0.37 | 0.04 | 0.11 | TRUE |
40 | GTEx | Thyroid | SELENBP1 | 0.23 | 0.19 | enet | 12 | 0.23 | 2.3e-17 | -5.3 | -5.8 | 8.6e-09 | 0.01 | 0.95 | 0.05 | FALSE |
41 | GTEx | Thyroid | ARNT | 0.08 | 0.10 | lasso | 10 | 0.10 | 7.8e-08 | 4.1 | -5.2 | 2.2e-07 | -0.05 | 0.94 | 0.06 | FALSE |
42 | METSIM | Adipose | POGZ | 0.06 | 0.05 | lasso | 12 | 0.03 | 9.3e-06 | -5.4 | -6.2 | 7.6e-10 | -0.05 | 0.97 | 0.02 | FALSE |
43 | METSIM | Adipose | PSMD4 | 0.03 | 0.05 | lasso | 4 | 0.04 | 6.1e-07 | -6.2 | 6.5 | 6.6e-11 | 0.22 | 0.12 | 0.88 | FALSE |
44 | METSIM | Adipose | RP11-196G18.24 | 0.27 | 0.01 | blup | 116 | 0.13 | 3.6e-19 | 4.2 | 7.4 | 1.2e-13 | 0.31 | 0.04 | 0.94 | FALSE |
45 | METSIM | Adipose | SCNM1 | 0.06 | 0.06 | lasso | 10 | 0.05 | 3.6e-08 | 5.8 | 6.3 | 3.6e-10 | 0.14 | 0.76 | 0.24 | FALSE |
46 | METSIM | Adipose | TMOD4 | 0.02 | 0.00 | blup | 312 | 0.01 | 3.2e-02 | -7.0 | 8.6 | 9.6e-18 | 0.11 | 0.03 | 0.63 | FALSE |
47 | YFS | Blood | MCL1 | 0.07 | 0.03 | bslmm | 278 | 0.03 | 4.4e-10 | 5.5 | -7.5 | 4.7e-14 | -0.10 | 1.00 | 0.00 | TRUE |
48 | YFS | Blood | PRUNE | 0.05 | 0.00 | enet | 33 | 0.02 | 5.8e-06 | -4.3 | -6.8 | 8.1e-12 | -0.06 | 0.09 | 0.29 | FALSE |
49 | YFS | Blood | SCNM1 | 0.09 | 0.04 | enet | 62 | 0.08 | 1.3e-24 | -6.1 | 6.0 | 2.5e-09 | 0.05 | 0.36 | 0.64 | FALSE |
50 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PIP5K1A | 0.04 | 0.05 | lasso | 6 | 0.05 | 8.8e-10 | -6.1 | -6.3 | 3.4e-10 | -0.15 | 0.29 | 0.71 | FALSE |
51 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SV2A | 0.03 | 0.02 | enet | 3 | 0.02 | 8.0e-06 | -3.1 | 7.0 | 3.0e-12 | 0.38 | 0.13 | 0.23 | FALSE |
52 | The Cancer Genome Atlas | Colon Adenocarcinoma | PIP5K1A | 0.05 | 0.03 | blup | 35 | 0.04 | 4.0e-03 | -6.8 | -6.7 | 1.7e-11 | -0.19 | 0.03 | 0.82 | FALSE |
53 | The Cancer Genome Atlas | Esophageal Carcinoma | PIP5K1A | 0.10 | 0.06 | lasso | 1 | 0.04 | 2.1e-02 | -5.9 | -6.0 | 2.7e-09 | -0.16 | 0.03 | 0.13 | TRUE |
54 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | GOLPH3L | 0.12 | 0.16 | blup | 49 | 0.16 | 4.8e-18 | -4.7 | 5.5 | 3.4e-08 | 0.07 | 1.00 | 0.00 | FALSE |
55 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PSMB4 | 0.03 | 0.00 | blup | 37 | 0.02 | 7.0e-03 | -5.4 | 7.6 | 2.6e-14 | 0.13 | 0.05 | 0.38 | FALSE |
56 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | SV2A | 0.05 | 0.02 | blup | 9 | 0.03 | 2.5e-04 | -10.8 | 10.3 | 8.7e-25 | 0.48 | 0.03 | 0.08 | FALSE |
57 | The Cancer Genome Atlas | Brain Lower Grade Glioma | PIP5K1A | 0.02 | 0.02 | lasso | 3 | 0.02 | 6.2e-03 | -6.8 | -6.9 | 6.1e-12 | -0.19 | 0.04 | 0.63 | FALSE |
58 | The Cancer Genome Atlas | Brain Lower Grade Glioma | SV2A | 0.04 | 0.00 | blup | 9 | 0.03 | 5.5e-04 | -10.3 | -9.3 | 1.7e-20 | -0.21 | 0.00 | 0.33 | TRUE |
59 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | MTMR11 | 0.12 | 0.09 | blup | 11 | 0.10 | 1.3e-05 | -10.8 | -6.5 | 1.1e-10 | -0.18 | 0.07 | 0.11 | FALSE |
60 | The Cancer Genome Atlas | Lung Adenocarcinoma | PIP5K1A | 0.03 | 0.01 | blup | 36 | 0.02 | 5.1e-03 | -6.3 | -6.1 | 1.0e-09 | -0.13 | 0.06 | 0.32 | TRUE |
61 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | MRPS21 | 0.04 | 0.03 | blup | 15 | 0.04 | 4.0e-05 | 1.9 | -5.2 | 2.1e-07 | 0.02 | 0.09 | 0.03 | FALSE |
62 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ARNT | 0.06 | 0.02 | lasso | 3 | 0.02 | 1.4e-03 | 5.5 | -5.4 | 7.1e-08 | -0.05 | 0.02 | 0.92 | FALSE |
63 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ENSA | 0.02 | 0.01 | enet | 3 | 0.01 | 2.5e-02 | -4.7 | 6.7 | 2.1e-11 | 0.08 | 0.01 | 0.68 | FALSE |
64 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MTMR11 | 0.02 | 0.02 | lasso | 3 | 0.02 | 3.7e-03 | -10.4 | -10.5 | 6.0e-26 | -0.30 | 0.03 | 0.03 | FALSE |
65 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SF3B4 | 0.03 | 0.02 | blup | 10 | 0.01 | 1.4e-02 | -10.4 | -11.4 | 3.7e-30 | -0.32 | 0.04 | 0.16 | FALSE |
66 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SV2A | 0.11 | 0.10 | blup | 9 | 0.11 | 3.8e-11 | -3.1 | 7.5 | 7.9e-14 | 0.40 | 1.00 | 0.00 | FALSE |
67 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | FCGR1A | 0.10 | 0.03 | lasso | 4 | 0.04 | 3.9e-02 | -10.8 | 8.6 | 7.7e-18 | 0.38 | 0.01 | 0.07 | FALSE |
68 | The Cancer Genome Atlas | Stomach Adenocarcinoma | POGZ | 0.04 | 0.01 | blup | 43 | 0.01 | 3.7e-02 | -5.0 | -5.6 | 2.5e-08 | 0.02 | 0.03 | 0.18 | FALSE |
69 | The Cancer Genome Atlas | Thyroid Carcinoma | PIP5K1A | 0.04 | 0.06 | lasso | 2 | 0.05 | 9.7e-06 | -6.1 | -6.2 | 7.4e-10 | -0.15 | 0.24 | 0.72 | FALSE |
70 | The Cancer Genome Atlas | Thyroid Carcinoma | SELENBP1 | 0.06 | 0.02 | enet | 7 | 0.05 | 2.3e-05 | -5.4 | -7.8 | 7.7e-15 | -0.13 | 0.12 | 0.81 | TRUE |