Hub : Genes

KCNN3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1220	0.0320	2.2e-07	0.036	0.068	0.092	0.092	0.112	3.1e-05	1.0e-08	2.6e-11	2.4e-11	1.7e-13
2	GTEx	Esophagus Muscularis	0.1200	0.0530	9.8e-03	-0.001	NA	0.022	NA	0.023	3.6e-01	NA	1.6e-02	NA	1.4e-02
3	GTEx	Lung	0.0964	0.0411	4.0e-03	0.013	NA	0.040	NA	0.023	3.0e-02	NA	4.7e-04	NA	7.0e-03
4	GTEx	Nerve Tibial	0.1293	0.0419	2.2e-04	0.009	NA	0.058	NA	0.059	6.9e-02	NA	6.5e-05	NA	5.4e-05
5	GTEx	Pituitary	0.4150	0.1150	9.5e-05	0.309	NA	0.254	NA	0.285	1.6e-08	NA	4.5e-07	NA	7.4e-08
6	TCGA	Lung Adenocarcinoma	0.0605	0.0221	5.1e-04	-0.002	0.030	0.011	NA	-0.001	9.7e-01	1.6e-04	1.5e-02	NA	4.4e-01
7	TCGA	Prostate Adenocarcinoma	0.0479	0.0232	7.4e-03	0.016	0.002	0.014	NA	0.016	7.1e-03	1.7e-01	1.2e-02	NA	7.0e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	2.9	4.5	11.7	-2.8	-1.2	-0.1	-0.5	3.4	-1.0	-3.1
Bipolar Disorder or Schizophrenia	4.4	10.8	24.7	-4.7	-2.7	-1.9	0.7	5.0	-0.9	-4.2
Depressed Affect (Nagel 2018)	0.9	1.8	4.2	-1.6	-0.5	1.2	-0.6	2.0	-1.4	-1.5
Depression (Nagel 2018)	2.7	4.0	9.9	-2.4	-2.0	-0.6	-1.1	1.9	-3.1	-1.7
Intelligence (Savage-Jansen 2018)	0.3	0.9	2.2	-0.0	1.5	0.7	-1.0	0.9	-1.0	-0.8
Neuroticism (Nagel 2018)	2.9	6.8	14.5	-2.6	-3.3	-0.7	-1.6	3.8	-1.2	-3.3
Schizophrenia (2018)	3.4	7.0	13.5	-3.7	-2.6	-2.4	1.3	3.6	-0.3	-2.9
Schizophrenia vs Biploar Disorder	0.3	0.4	1.6	-0.4	0.8	-1.3	0.5	0.1	0.3	0.2
Worry (Nagel 2018)	2.3	4.8	20.4	-1.0	-4.5	-1.3	-0.7	2.4	0.2	-2.1
Alzheimer’s Disease (in mother)	0.2	0.2	0.6	0.1	-0.7	0.5	0.1	-0.5	-0.6	-0.0
Alzheimer’s Disease (in father)	1.3	1.4	3.3	-1.8	0.5	0.5	-0.2	1.4	-1.5	-1.3
Alzheimer’s Disease (including proxy)	0.4	0.6	1.6	-1.0	-1.3	0.5	0.0	0.5	-0.9	-0.6
Crohns Disease (2017)	1.1	2.5	12.3	0.4	-1.3	3.5	1.3	-0.8	-0.1	0.9
Irritable Bowel Disease (IBD)	1.9	4.5	22.5	1.2	-0.2	4.7	1.6	-1.4	-0.1	1.8
Ulcerative Colitis (UC)	0.9	1.6	9.5	0.5	0.1	3.1	0.3	-0.6	-0.4	1.0
Major Depression (MDD)	1.0	1.2	5.1	-0.1	1.3	2.3	0.8	0.7	-0.4	0.4
Reaction Time	3.5	6.7	15.2	-3.9	-1.5	-1.1	-3.3	2.3	-2.1	-2.7
Verbal and Numeric Reasoning (VNR)	0.4	0.9	4.0	0.4	-0.1	-0.2	-0.6	1.0	-2.0	-0.9
Breast Cancer	1.1	2.6	9.4	0.1	1.9	-3.1	1.5	-1.1	0.2	1.4
Ovarian Cancer	0.1	0.2	0.4	0.6	-0.4	-0.6	-0.4	0.3	0.4	-0.0
Prostate Cancer	7.1	10.0	18.0	-3.3	-0.7	-1.8	-4.0	4.2	-2.2	-4.2
Age at First Birth	0.4	0.5	2.8	-0.7	0.5	0.3	-1.7	0.2	0.1	-0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	2.4	3.3	6.5	1.8	0.6	-1.7	1.9	-2.4	0.4	2.5
Coronary Artery Disease (CAD)	3.7	4.4	10.0	-1.0	-3.2	-2.7	-0.0	2.4	-0.8	-2.5
Crohns Disease (2012)	1.9	3.1	8.6	1.3	-1.1	2.9	1.9	-1.7	-0.1	2.0
Mean Putamen Volume	0.2	0.2	1.2	-0.0	1.1	-0.1	-0.0	-0.1	0.4	-0.2
Fasting Glucose	1.7	2.0	3.7	1.5	1.1	-0.3	1.3	-1.9	1.0	1.9
HbA1C	3.6	4.0	8.3	-0.5	-0.5	-1.3	-2.9	2.7	-1.8	-2.7
HDL Cholesterol	0.5	0.8	4.9	-0.5	-0.6	-2.2	0.1	0.2	-0.0	-0.2
LDL Cholesterol	0.2	0.4	1.8	0.3	-1.4	-0.1	0.3	0.4	-0.1	-0.6
Lupus	0.7	1.1	3.3	-0.1	1.8	0.1	0.1	-1.1	-1.0	1.5
Neuroticism (2016)	3.5	5.0	11.7	-2.3	-3.4	-0.1	-0.7	3.3	-0.6	-2.5
Primary Biliary Cirrhosis	1.7	2.4	4.5	-1.2	-1.6	-0.8	-2.0	1.8	-0.3	-2.1
Rheumatoid Arthritis	1.2	1.7	5.6	1.6	0.9	2.4	1.0	-1.0	-0.6	0.7
Schizophrenia (2014)	3.9	8.6	20.3	-4.5	-2.3	-2.1	0.5	4.2	-0.8	-3.4
Triglycerides	0.3	0.5	1.6	-0.2	0.3	-1.0	1.3	0.5	-0.4	-0.2
Type 2 Diabetes (T2D) (2012)	0.9	1.0	3.3	-0.2	1.6	1.8	-0.1	-0.1	-0.9	0.7
Ulcerative Colitis	1.4	2.1	5.8	1.4	0.7	2.4	1.4	-1.1	-0.4	1.7
Blood Eosinophil Count	1.3	10.3	16.7	-3.3	-1.7	-3.1	-3.7	4.1	-1.4	-4.0
Blood Platelet Count	0.4	4.9	14.4	-1.5	2.1	3.8	-2.1	1.9	-1.5	-1.7
Blood Red Count	0.4	3.6	7.8	2.8	-0.5	1.9	0.9	-2.5	-0.4	2.5
Blood White Count	0.3	1.9	5.3	0.1	-1.5	2.3	-2.1	0.0	-0.8	0.5
Heel T-Score	0.3	2.7	5.1	1.7	0.1	-2.2	1.2	-2.1	-0.7	2.2
BMI	1.6	9.3	16.2	2.4	4.0	0.7	2.1	-4.0	2.6	4.0
Height	0.1	2.2	6.8	2.1	0.3	1.2	0.6	-1.1	2.6	1.1
Waist Hip Ratio (WHR)	1.0	4.3	9.6	-3.0	0.3	3.1	-2.6	2.1	-0.4	-0.6
Systolic Blood Pressure	0.1	0.7	1.5	1.2	-0.1	-1.1	-0.4	-1.1	-0.7	0.7
Smoking Status	0.3	0.8	3.4	-0.2	0.5	1.8	1.0	-0.6	-0.0	0.8
Allergy or Eczema	0.2	0.5	3.2	0.0	1.8	-0.2	0.6	0.4	-0.4	-0.2
Cardiovascular Disease	0.2	0.8	1.8	-0.4	1.3	0.5	1.0	-0.8	0.6	1.2
Hypothyroidism (self reported)	1.3	3.0	6.7	1.4	-1.5	0.3	1.7	-1.6	2.6	2.0
Respiratory disease	0.8	1.9	4.0	-1.5	0.8	0.2	-1.8	2.0	-0.7	-1.6
Type 2 Diabetes (T2D) (2018)	0.5	0.9	3.7	-0.7	-0.8	0.7	-1.9	0.7	0.3	-0.7
Lung FEV1/FVC ratio	0.4	2.3	6.1	2.5	-2.1	-0.7	0.5	-0.1	2.1	-0.5
Lung FVC	0.6	2.9	8.0	1.9	2.8	-0.7	0.2	-2.0	1.4	1.7
Neuroticism	2.0	4.9	12.4	-2.0	-2.9	-0.1	-0.7	3.5	-0.3	-3.0
Chronotype (morning person)	0.4	0.8	2.1	0.9	-1.4	-1.0	-1.0	-0.1	0.3	-0.9
Hair Pigment	0.1	3.2	14.7	1.0	-2.1	3.8	-0.1	-1.3	-0.3	0.7
Tanning	0.0	0.4	0.8	-0.3	0.9	-0.8	0.5	-0.2	0.8	0.5
Hand grip strength (left)	2.3	5.9	11.3	2.9	2.1	0.8	2.5	-2.9	1.6	3.4
Number of treatments/medications taken	0.8	1.4	5.0	0.3	0.3	-0.1	2.2	-0.3	1.9	1.0
Average weekly spirits intake	1.5	1.9	4.5	-1.2	0.1	-1.8	-1.9	-0.4	-2.1	-0.4
Sensitivity / hurt feelings	5.3	9.0	18.7	-3.6	-2.9	-1.5	-2.1	4.3	-1.6	-3.7
Frequency of depressed mood in last 2 weeks	3.4	4.7	8.6	-2.9	-2.5	-0.4	-1.9	2.3	-2.1	-2.2
Hearing difficulty/problems: Yes	0.5	0.8	2.0	1.1	-1.4	-0.5	-0.1	1.2	0.3	-0.7
Relative age of first facial hair	0.3	0.6	2.5	-0.1	1.0	0.9	0.0	0.1	1.6	0.1
Other serious medical condition/disability diagnosed by doctor	0.8	1.1	2.3	-1.2	0.1	1.5	1.0	0.9	1.4	-0.2
Ever used hormone-replacement therapy (HRT)	0.9	1.2	4.2	0.4	-0.7	-2.0	1.1	-0.2	1.3	0.7
Ever had hysterectomy (womb removed)	0.3	0.3	1.5	0.4	-0.8	0.4	-0.2	0.1	-1.2	0.2
Systolic blood pressure, automated reading	0.5	1.4	3.9	1.4	0.3	-1.1	0.1	-2.0	-0.2	1.5
Eye problems/disorders: Diabetes related eye disease	2.9	3.2	7.0	-1.8	-2.0	-1.9	-1.1	1.9	-0.1	-2.6
Angina	0.7	0.9	4.6	-0.4	0.2	0.6	-0.1	-0.6	2.1	0.8
Medication for hormone replacement therapy	0.3	0.3	1.4	-0.3	-1.2	0.5	0.3	-0.0	0.3	0.5
Vitamin and mineral supplements	1.2	1.7	4.0	-0.9	-2.0	-0.9	-1.8	1.0	-0.8	-1.2
Supplements: Zinc	1.1	1.2	6.4	-1.1	-0.1	-0.6	-0.5	0.4	-2.5	-0.2
Medication: Co-codamol	0.6	0.7	3.0	-1.7	0.0	-0.3	-0.3	1.0	0.0	-0.8
Medication: Metformin	0.9	1.3	3.7	-0.9	-1.4	0.3	-1.9	0.8	1.3	-0.7
Diabetes (father)	0.4	0.5	1.8	-1.3	0.2	0.2	-0.0	0.1	-1.2	-0.0
Diabetes (mother)	0.3	0.4	1.9	-0.1	0.5	-0.2	0.3	-0.1	1.4	0.6
Severe depression (siblings)	1.1	1.2	3.5	-1.9	-1.0	-0.5	-0.1	1.1	-0.9	-1.3
Pack years adult smoking proportion	0.3	0.4	1.0	-0.2	-0.3	0.9	-0.9	-0.1	1.0	0.4
Impedance of leg (right)	3.1	15.1	34.6	-4.5	-3.0	1.1	-3.9	5.9	-2.2	-4.6
Leg fat-free mass (left)	1.7	9.0	15.4	3.1	3.1	-0.3	3.2	-3.9	2.5	3.5
Trunk fat percentage	0.2	0.7	2.2	-0.2	1.3	0.1	0.8	-0.1	1.5	0.6
Hand grip strength (right)	1.6	4.3	9.4	3.1	1.4	0.6	1.9	-2.6	0.8	2.7
Townsend deprivation index at recruitment	0.2	0.3	0.8	0.3	0.9	-0.7	0.5	-0.1	0.3	0.6
Current tobacco smoking	0.2	0.3	0.8	-0.7	-0.1	0.9	-0.3	-0.1	-0.5	0.5
Average weekly fortified wine intake	0.7	0.8	1.8	-1.3	-0.9	-0.8	-0.2	1.1	-0.1	-1.1
Maternal smoking around birth	1.1	1.6	4.5	0.1	-1.1	-1.5	1.1	-1.0	2.1	1.1
Fed-up feelings	0.7	1.3	4.3	-1.1	-0.6	0.3	-0.1	2.1	-0.2	-1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.9	3.1	-0.8	-0.9	0.9	-0.1	0.6	-1.8	-0.6
Relative age voice broke	1.3	2.1	5.8	-0.8	-0.9	-2.4	-1.0	1.8	-0.4	-1.7
Taking other prescription medications	1.7	2.7	7.4	1.3	-0.1	-0.2	2.6	-0.9	2.7	1.4
Age when periods started (menarche)	0.4	0.9	3.1	-0.2	0.7	1.6	0.5	0.2	1.8	0.3
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.6	1.6	0.8	0.1	0.5	-0.6	0.1	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	1.3	0.7	0.4	-0.2	-0.2	-1.2	0.2	0.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.5	0.3	0.6	-1.2	-1.1	0.6	-0.9	-0.7
Qualifications: CSEs or equivalent	0.2	0.2	1.0	0.3	-0.4	-0.2	-0.4	0.1	1.0	0.1
Serious illness, injury or assault to yourself	0.3	0.4	1.6	-0.6	-1.2	-0.1	-0.1	0.5	0.5	-0.7
High blood pressure	0.2	0.4	1.3	-1.2	0.5	-0.5	1.0	0.0	0.4	0.3
Hayfever, allergic rhinitis or eczema	0.3	0.6	3.4	-0.4	1.9	-0.3	0.3	0.5	-0.5	-0.4
Multivitamins +/- minerals	1.8	2.3	4.3	0.4	1.9	0.1	2.0	-1.3	2.1	1.7
Stomach or abdominal pain in last month	1.0	1.2	5.1	-2.3	-1.0	-0.5	-0.4	1.0	-0.8	-0.6
Supplements: Glucosamine	0.6	0.8	2.9	0.7	0.7	-1.7	0.9	-0.8	0.2	0.8
Diverticular disease/diverticulitis (self-reported)	1.4	1.7	6.2	0.9	-2.5	-0.4	-2.0	-0.4	-0.1	0.2
Medication: Atenolol	0.6	0.7	1.8	0.8	0.7	-1.3	0.2	-1.1	0.7	0.6
Medication: Levothyroxine sodium	2.3	3.9	11.5	1.7	0.7	1.4	1.0	-1.8	3.4	2.4
Sitting height	0.1	1.0	3.7	-0.1	-0.0	1.6	0.5	-0.0	1.9	0.2
Chronic bronchitis/emphysema (father)	0.7	0.8	2.0	-1.1	0.6	-0.6	-1.4	0.8	-0.2	-1.0
High blood pressure (mother)	1.4	2.0	4.2	-0.8	-0.4	-1.9	0.4	2.0	0.8	-2.0
Body mass index (BMI)	1.2	5.2	8.8	1.7	3.0	-1.0	2.0	-2.9	1.9	2.7
Impedance of leg (left)	3.0	14.7	32.6	-4.5	-3.1	0.8	-3.6	5.7	-2.4	-4.5
Leg predicted mass (left)	1.7	9.0	15.2	3.1	3.1	-0.3	3.2	-3.9	2.5	3.5
Trunk fat mass	0.5	2.3	4.0	0.8	1.8	-0.0	1.8	-1.4	2.0	1.8
Waist circumference	1.2	4.3	8.4	1.3	2.9	1.3	1.3	-2.1	2.6	2.4
Number of incorrect matches in round	0.7	1.1	4.1	-0.5	-0.9	2.0	-0.1	-0.0	1.6	-0.4
Past tobacco smoking	0.9	1.6	3.6	-0.9	-1.2	-1.7	-1.9	0.9	-0.8	-1.0
Alcohol usually taken with meals	0.4	0.7	2.5	0.5	-1.6	-0.4	0.8	0.7	-0.2	-0.8
Nervous feelings	1.7	3.1	11.2	-0.4	-3.4	-1.6	-0.1	1.9	1.1	-1.7
Frequency of tenseness / restlessness in last 2 weeks	3.2	5.0	8.1	-2.6	-2.2	-0.6	-2.5	2.8	-0.9	-2.8
Hearing difficulty/problems with background noise	0.2	0.3	1.5	1.2	0.2	0.6	0.0	0.3	0.3	0.3
Hair/balding pattern: Pattern 2	0.6	0.7	2.2	1.5	0.9	0.1	1.0	-0.9	-0.2	0.5
Had menopause	0.2	0.2	1.2	-1.1	0.1	-0.3	-0.3	0.2	0.2	-0.2
Had other major operations	0.7	0.9	1.9	1.2	-1.0	-0.5	-0.2	-1.4	0.4	1.1
Forced vital capacity (FVC)	0.2	0.8	2.8	1.3	1.7	-0.0	-0.1	-0.8	-0.1	0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.9	1.4	0.3	0.1	-0.3	-1.1	0.1	1.1
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.5	-0.9	-0.6	0.3	-0.1	1.2	-0.7	-0.6
Qualifications: None of the above	0.8	1.7	4.8	2.2	-0.8	0.3	-0.1	-1.5	1.4	1.3
Financial difficulties in last 2 years	0.6	0.8	3.2	-0.6	1.8	-0.4	-0.4	0.9	-0.6	-0.5
Mouth/teeth dental problems	0.9	1.4	5.7	0.1	-1.6	-2.4	-0.4	0.8	-0.7	-0.7
Heart attack	0.2	0.3	0.9	0.9	0.2	-0.2	0.0	-0.8	0.4	0.5
Allergy	0.2	0.4	1.2	0.4	-1.1	-0.4	0.4	-0.8	0.2	0.8
Pain all over the body in last month	1.2	1.2	2.7	-0.3	1.5	1.1	1.5	0.0	1.6	0.5
Diabetes (self-reported)	0.5	0.7	1.6	-1.0	-1.1	0.7	-1.3	0.6	0.1	-0.6
Hayfever/allergic rhinitis (self-reported)	1.5	2.0	3.4	1.8	1.4	0.8	1.7	-1.5	0.7	1.5
Medication: Ramipril	0.2	0.2	1.3	0.0	-1.1	0.1	-0.2	0.2	-0.2	0.0
Medication: Simvastatin	0.5	0.7	1.8	-0.8	1.3	0.8	-1.3	-0.2	0.5	0.4
Fluid intelligence score	0.4	0.8	1.9	0.2	0.2	-0.1	-1.4	0.9	-1.4	-1.0
Illnesses of siblings	0.4	0.6	1.1	-0.1	0.4	-0.6	-1.0	0.8	-1.0	-1.0
Neuroticism score	3.2	6.8	14.6	-1.9	-3.8	-0.5	-1.3	3.8	-1.4	-3.3
Weight	1.3	6.5	9.8	2.0	2.7	-0.6	2.6	-3.1	2.9	3.0
Impedance of arm (right)	2.7	12.4	29.4	-3.1	-4.2	0.8	-3.0	5.4	-1.9	-4.3
Arm fat percentage (right)	0.2	0.7	2.6	0.1	1.6	-0.6	0.7	-0.2	1.1	0.5
Trunk fat-free mass	1.4	8.0	15.0	2.8	2.4	-0.6	2.9	-3.9	2.9	3.3
Hip circumference	1.1	4.7	7.0	1.9	2.4	-0.6	2.6	-2.5	2.2	2.4
Time employed in main current job	0.5	0.6	1.1	-0.5	-1.0	0.7	-1.1	0.7	0.3	-0.8
Alcohol intake versus 10 years previously	0.3	0.5	2.2	0.8	-0.4	-0.4	-0.2	-0.3	-1.5	0.3
Father’s age at death	1.0	1.4	4.1	-1.2	0.4	0.2	-0.9	2.0	0.5	-1.8
Worrier / anxious feelings	2.3	4.3	13.1	-1.6	-3.6	-0.8	-1.1	2.3	-0.8	-2.5
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.6	-1.0	0.1	-1.0	0.2	1.6	-0.0	-0.9
Falls in the last year	0.6	0.8	3.2	-1.2	0.4	-1.8	0.2	0.4	0.9	-0.3
Hair/balding pattern: Pattern 3	1.1	1.7	4.2	-1.6	0.3	-0.8	-0.8	2.1	-1.0	-1.6
Number of live births	0.2	0.3	0.9	0.4	-0.0	-0.8	-0.3	0.3	0.9	0.1
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	5.3	2.3	0.9	-0.9	-0.0	-0.7	0.3	0.2
Pulse rate	2.0	3.4	7.0	-1.2	-2.6	-1.7	-1.3	2.2	0.3	-2.4
Happiness	0.6	0.8	2.0	0.1	-0.4	-0.4	-0.8	1.4	-0.7	-1.4
Noisy workplace	0.6	0.7	2.5	0.7	-0.4	-0.2	0.9	-0.5	1.6	0.7
Qualifications: A levels/AS levels or equivalent	2.7	6.1	13.0	-3.6	0.4	-1.1	-1.2	3.3	-2.8	-2.8
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.7	2.5	-0.2	-1.3	-0.2	-1.6	-0.1	-0.2	-0.6
Mouth/teeth dental problems: Dentures	1.2	2.0	5.9	0.8	0.5	2.4	0.1	-1.2	2.1	1.1
Asthma	0.5	1.0	2.5	-1.3	-0.9	-0.2	-0.7	1.6	0.2	-1.1
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.8	1.7	-1.0	-0.4	-1.3	-0.4	1.2	-0.3	-0.9
Medication: Cholesterol lowering	1.1	1.6	4.5	0.2	0.6	1.9	0.7	-1.1	2.1	1.1
Depression (self-reported)	0.4	0.4	1.1	0.6	1.1	0.1	0.3	0.3	-1.0	-0.5
Medication: Lansoprazole	1.2	1.4	3.5	1.4	0.5	-0.0	1.2	-1.9	0.2	1.6
Prospective memory result	0.8	1.0	2.8	-0.6	-1.7	-1.3	-0.4	0.3	1.2	-0.7
Lung cancer (father)	2.0	2.3	5.1	1.0	0.8	1.4	1.7	-1.9	1.0	2.3
Illnesses of mother	0.5	0.6	2.0	-0.8	1.4	0.5	0.0	-0.3	-1.0	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	2.0	7.6	2.8	1.5	-0.5	0.8	-1.2	0.7	0.9
Pulse wave Arterial Stiffness index	0.6	0.8	1.6	1.0	0.4	1.3	-0.9	-0.6	-1.0	0.7
Impedance of arm (left)	2.2	10.0	23.6	-3.0	-3.8	1.5	-2.3	4.9	-1.3	-3.7
Arm fat mass (right)	0.7	2.9	5.6	1.0	2.4	-0.8	1.7	-1.7	2.1	1.8
Trunk predicted mass	1.4	7.9	15.0	2.8	2.3	-0.6	2.8	-3.9	2.8	3.3
Standing height	0.1	1.2	5.0	0.7	-0.3	0.8	1.0	-0.8	2.2	0.9
Length of working week for main job	0.2	0.2	1.4	-0.3	-0.3	1.2	0.1	-0.0	-0.2	0.1
Exposure to tobacco smoke at home	0.4	0.4	1.9	0.1	-0.1	-0.8	-1.4	-0.0	-0.7	0.1
Breastfed as a baby	3.3	4.1	6.7	1.6	2.6	0.8	1.3	-2.3	2.4	2.4
Tense / ‘highly strung’	1.7	2.8	6.6	-2.0	-1.8	-0.7	-0.2	2.6	0.2	-2.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.8	2.8	0.2	-0.8	-0.9	-0.3	1.3	-0.2	-1.7
Hair/balding pattern: Pattern 4	0.5	1.2	2.5	1.5	1.6	-0.5	-0.6	-1.0	1.2	0.7
Birth weight of first child	3.9	7.1	16.6	2.4	3.2	4.1	1.2	-2.7	1.3	2.6
Peak expiratory flow (PEF)	0.7	1.6	6.1	2.5	-0.7	-2.1	0.3	-0.1	-0.1	-0.3
Pulse wave reflection index	1.5	1.9	4.2	1.0	1.1	2.0	-0.2	-1.9	-0.6	1.6
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.0	-0.7	1.1	0.3	-0.0	1.3	-1.4	-1.1
Loud music exposure frequency	1.8	1.9	4.6	-1.5	-2.1	-0.8	-0.8	1.6	-1.1	-1.2
Qualifications: O levels/GCSEs or equivalent	3.3	5.3	10.1	-3.1	-0.7	-1.1	-1.2	2.7	-3.2	-2.6
Mouth/teeth dental problems: Bleeding gums	1.4	1.8	7.4	-0.3	1.8	2.7	0.2	-0.7	-1.0	0.8
Blood clot in the leg (DVT)	1.8	2.4	4.8	-1.4	-0.5	1.0	-1.6	2.0	-1.4	-2.2
Medication: Paracetamol	0.3	0.5	1.5	-0.6	-0.2	-0.7	0.8	1.2	0.5	-0.5
Headache pain in last month	0.8	1.4	3.2	-0.9	-1.0	-0.8	-0.1	1.8	-0.9	-1.7
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	1.8	0.4	-0.1	-1.3	-1.2	0.7	-0.8	-0.9
Glaucoma (self-reported)	1.5	1.7	6.1	1.2	2.5	0.9	-0.7	-1.2	1.1	0.9
Gout (self-reported)	4.2	5.8	13.8	2.1	1.6	0.8	2.3	-3.7	0.5	3.6
Hypothyroidism/myxoedema (self-reported)	2.0	3.9	8.6	1.6	0.0	0.9	1.9	-2.1	2.9	2.6
Medication: Amlodipine	0.1	0.1	0.3	-0.5	-0.3	0.3	-0.5	-0.4	-0.1	0.4
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.5	0.5	-0.7	-0.1	-0.4	0.5	0.3	-0.3
Birth weight	3.0	6.6	14.4	2.1	2.6	3.8	1.1	-2.9	0.8	3.1
Chronic bronchitis/emphysema (mother)	0.6	0.7	1.5	-0.6	-0.9	-1.2	-0.2	0.7	-1.2	-0.2
High blood pressure (siblings)	0.6	0.9	4.0	-2.0	0.1	-0.1	-0.6	1.1	-0.0	-0.7
Forced vital capacity (FVC), Best measure	0.6	2.3	6.3	2.1	2.5	0.3	0.8	-1.4	0.7	1.3
Body fat percentage	0.2	0.9	3.1	-0.1	1.8	-0.1	0.9	-0.3	1.4	0.8
Leg fat percentage (right)	0.4	1.4	4.6	0.0	2.1	-0.3	1.1	-0.8	1.2	1.4
Arm fat-free mass (right)	1.7	8.8	16.6	2.6	2.9	-0.3	2.9	-4.1	3.0	3.5
Exposure to tobacco smoke outside home	0.8	1.0	2.4	-0.2	-0.7	0.4	-1.4	1.4	-0.5	-1.6
Comparative body size at age 10	0.3	0.8	3.5	0.6	1.9	-0.6	-0.1	-0.9	-0.8	0.1
Number of full brothers	0.4	0.5	0.7	0.8	-0.5	-0.8	-0.2	-0.8	-0.7	0.8
Worry too long after embarrassment	3.2	5.4	12.4	-1.2	-2.6	-0.5	-2.3	3.5	-0.6	-3.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.1	3.8	-0.6	-1.0	1.9	-0.6	0.9	-0.1	-1.0
Wheeze or whistling in the chest in last year	0.4	0.7	2.0	-1.4	-0.2	0.8	0.1	1.4	0.0	-0.7
Number of children fathered	2.2	2.5	6.2	2.5	1.0	-1.3	1.0	-2.1	1.0	1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	1.3	-0.4	-1.1	-0.4	-0.7	-0.4	-0.6	-0.4
Age at first live birth	0.1	0.2	0.6	-0.8	-0.3	0.6	0.2	-0.2	0.3	-0.2
Pulse wave peak to peak time	0.6	0.7	1.4	-1.1	-0.4	-1.2	0.8	0.6	0.9	-0.8
Health satisfaction	0.8	1.0	2.3	1.5	0.7	-0.5	1.1	-0.5	1.3	0.9
Shortness of breath walking on level ground	3.2	3.8	11.8	2.0	0.9	-0.6	3.4	-1.2	2.4	1.7
Qualifications: College or University degree	1.1	3.4	7.0	-1.7	-1.2	-1.8	-1.1	2.5	-1.2	-2.6
Eye problems/disorders: None of the above	0.9	1.0	5.6	0.4	-0.9	-2.4	-0.3	0.3	-0.4	-0.1
Mouth/teeth dental problems: Loose teeth	0.8	0.9	1.8	-1.3	-0.8	-0.7	-1.1	0.2	-1.3	-0.6
Emphysema/chronic bronchitis	2.4	2.7	5.4	-1.8	-0.1	1.8	-2.3	1.9	-0.7	-1.7
Medication for pain relief, constipation, heartburn	0.9	1.5	5.2	0.0	0.1	0.7	-2.3	-0.4	-2.2	-0.2
Neck or shoulder pain in last month	0.7	1.0	3.1	-1.1	-0.4	-1.8	-0.0	1.0	-0.8	-0.8
Medication: Blood pressure	0.3	0.5	2.0	0.2	0.4	0.4	1.4	-0.6	0.3	0.9
Angina (self-reported)	0.5	0.7	3.9	-0.2	-0.0	0.3	0.1	-0.6	2.0	0.7
Migraine (self-reported)	1.2	1.5	5.0	-0.5	0.4	-0.8	-0.7	2.2	-0.9	-1.8
Medication: Ibuprofen	0.6	0.7	2.6	-0.9	0.6	-1.6	-0.5	0.8	-0.4	-0.7
Medication: Allopurinol	4.7	6.2	17.5	2.2	0.8	0.3	1.9	-4.2	1.1	3.9
Medication: Omeprazole	2.2	2.6	8.2	1.1	1.0	1.2	2.0	-1.1	2.9	1.2
Medication: Seretide 50 evohaler	0.4	0.5	1.0	0.6	-0.8	0.4	0.2	-0.8	0.8	1.0
Mean time to correctly identify matches	3.9	7.4	18.4	-4.3	-1.9	-1.3	-3.2	2.4	-2.2	-2.7
Heart disease (mother)	1.5	1.8	4.5	1.6	-0.9	1.1	-0.6	-1.5	2.1	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.5	4.2	8.9	3.0	-0.2	0.8	2.4	-1.9	2.8	1.7
Whole body fat mass	0.7	3.1	5.5	1.1	2.3	-0.2	1.8	-1.8	2.1	2.0
Leg fat mass (right)	1.0	3.7	8.6	1.1	2.9	-0.3	1.8	-2.1	1.7	2.4
Arm predicted mass (right)	1.8	9.4	18.0	2.6	3.0	-0.2	3.1	-4.2	2.9	3.7
Pulse rate, automated reading	2.1	6.7	12.5	-3.2	-2.2	-1.2	-2.4	3.5	0.0	-3.4
Alcohol intake frequency.	0.4	0.9	2.1	-1.1	1.0	0.4	0.2	1.4	0.5	-1.2
Comparative height size at age 10	0.9	4.7	10.0	2.0	-0.4	0.7	2.3	-3.1	1.9	3.2
Number of full sisters	0.7	0.8	1.4	0.5	-1.1	-1.2	1.1	-0.7	0.8	0.7
Suffer from ‘nerves’	2.0	3.1	12.7	-0.7	-3.6	-1.0	-0.9	1.7	-1.1	-1.6
Overall health rating	0.5	1.0	1.8	-1.3	-1.3	-1.0	0.1	1.3	0.4	-0.9
Chest pain or discomfort	0.3	0.5	1.5	-0.2	-0.3	1.2	0.8	-0.5	0.0	0.8
Had major operations	1.1	1.3	3.7	1.1	1.3	0.7	0.7	-0.7	1.9	0.9
Age at last live birth	0.7	1.0	1.7	-1.3	1.1	1.1	-0.7	0.7	1.2	-0.7
Family relationship satisfaction	0.8	1.0	2.5	-0.6	-0.8	-0.0	-0.6	1.3	-1.1	-1.6
Leg pain on walking	0.4	0.5	2.6	-0.0	1.6	-0.0	1.0	0.1	0.5	0.1
Qualifications: NVQ or HND or HNC or equivalent	4.2	5.1	8.0	1.4	2.6	1.4	2.3	-2.8	2.2	2.6
Commuting to job workplace: Car/motor vehicle	0.7	0.8	2.1	1.3	0.6	-0.3	0.5	-1.4	0.4	1.1
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	3.7	1.9	0.6	0.8	1.1	-0.6	-0.4	0.6
Medication: Aspirin	2.1	2.8	10.3	0.5	-0.0	1.4	2.3	-0.9	3.2	1.2
Supplements: Vitamin C	0.5	0.5	1.2	-0.8	0.8	0.2	0.3	0.8	-1.1	-0.8
Knee pain experienced in last month	1.0	1.5	3.7	1.3	0.8	-0.6	0.4	-1.9	0.7	1.9
Hypertension (Self-reported)	0.2	0.6	2.2	-1.2	0.3	-0.1	1.5	-0.1	0.3	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.1	2.5	6.2	1.4	0.0	-0.3	1.6	-2.5	1.6	2.0
Illnesses of father: Heart disease	0.5	0.7	1.7	-0.8	-0.9	-1.0	-0.3	0.3	1.3	-0.8
Illnesses of siblings: Diabetes	0.9	1.2	3.8	-1.5	0.4	-2.0	0.8	0.7	-0.1	-0.9
Smoking status: Previous	2.4	3.6	6.8	1.7	1.8	2.6	2.4	-1.6	1.0	1.7
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	1.8	0.3	0.2	0.4	1.2	-1.1	-0.7	1.3
Whole body fat-free mass	1.6	9.1	16.6	3.0	2.9	-0.6	3.1	-4.1	2.8	3.5
Leg fat-free mass (right)	1.7	9.1	16.8	3.2	2.7	-0.6	3.3	-4.1	2.3	3.5
Arm fat percentage (left)	0.3	1.1	2.9	0.4	1.7	-0.3	1.1	-0.7	1.4	1.0
Average weekly red wine intake	0.4	0.6	1.2	0.9	0.2	-0.1	0.9	-1.1	0.8	0.8
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.1	-0.2	-0.6	-0.9	1.1	-0.1	1.0	0.2
Mood swings	2.8	5.1	9.4	-2.0	-2.0	1.1	-2.3	3.1	-1.9	-2.8
Loneliness, isolation	0.5	0.7	3.2	-0.5	-1.8	0.6	0.1	0.7	-0.9	-0.4
Long-standing illness, disability or infirmity	0.5	0.8	2.9	1.1	0.3	0.6	1.7	-0.4	0.5	0.9
Ever had bowel cancer screening	1.7	2.0	12.3	0.2	3.5	0.6	-0.3	-0.7	0.3	0.7
Diabetes diagnosed by doctor	0.7	1.2	2.5	-1.1	-1.0	0.6	-1.6	1.0	1.1	-1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.5	0.9	-0.5	-0.7	0.2	0.6	0.7	-0.7	-1.0
Friendships satisfaction	1.3	1.6	4.3	-1.0	-0.5	-0.9	-0.1	2.1	-1.3	-1.8
Qualifications: nursing, teaching	0.5	0.8	2.8	-0.3	1.7	-0.7	-0.5	1.0	-0.1	-1.0
Commuting to job workplace: Walk	0.5	0.5	1.4	-1.1	0.7	0.3	0.6	0.5	-1.2	-0.1
Eye problems/disorders: Cataract	0.6	0.7	1.5	-1.2	0.2	1.0	0.9	-0.8	0.5	0.6
Mouth/teeth dental problems: Mouth ulcers	0.2	0.4	1.9	-0.2	1.4	0.1	-0.0	-0.5	0.7	0.2
Medication for cholesterol	0.2	0.3	0.7	0.8	-0.1	0.5	0.9	-0.0	-0.5	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.3	0.8	-0.1	-0.5	-0.8	0.9	0.6	-0.0	-0.1
Back pain experienced in last month	0.3	0.5	1.3	1.0	-1.1	-0.8	-0.2	-0.4	0.1	0.3
Mineral and other dietary supplements	0.4	0.5	2.9	-0.2	-0.4	1.7	-0.2	0.2	-0.5	-0.5
Breast cancer (self-reported)	1.1	1.3	5.5	-2.3	1.0	-1.1	-0.4	0.8	0.2	-0.6
Asthma (self-reported)	0.6	1.3	2.8	-1.3	-1.2	-0.3	-0.9	1.7	-0.1	-1.4
Osteoporosis (self-reported)	0.7	0.9	2.2	-0.9	-0.2	-0.4	-0.6	1.5	-0.4	-1.5
Osteoarthritis (self-reported)	1.2	1.5	3.8	1.4	0.7	0.2	1.3	-1.9	0.8	1.6
Medication: Aspirin	1.8	2.4	9.8	0.5	0.1	1.1	2.0	-0.7	3.1	1.1
Medication: Gliclazide	1.1	1.2	2.6	-0.8	-1.4	0.8	-1.0	1.6	0.3	-1.1
Illnesses of father: None of the above (group 1)	2.6	3.2	9.8	3.1	1.0	0.9	0.4	-2.3	0.7	2.3
Smoking status: Current	0.2	0.3	0.7	-0.8	-0.6	0.2	-0.6	0.4	-0.6	-0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	6.4	2.5	1.5	0.1	0.8	-1.4	0.1	0.9
Whole body water mass	1.6	9.2	16.8	3.0	2.9	-0.6	3.1	-4.1	2.9	3.5
Leg predicted mass (right)	1.7	9.3	17.3	3.2	2.8	-0.5	3.4	-4.2	2.3	3.6
Arm fat mass (left)	0.8	3.1	4.9	1.2	2.2	-0.6	1.8	-1.8	2.1	2.0
Number of self-reported non-cancer illnesses	0.3	0.6	1.0	0.2	0.6	1.0	0.9	-0.7	1.0	0.8
Average weekly champagne plus white wine intake	1.1	1.5	3.0	-0.8	-1.5	-1.3	-1.7	1.1	-0.1	-1.4
Miserableness	1.5	2.7	8.2	-1.9	-0.5	-0.0	-0.2	2.9	-0.9	-2.4
Guilty feelings	2.0	3.0	7.5	-1.1	-1.9	-1.4	0.4	2.5	-0.8	-2.7
Wears glasses or contact lenses	0.3	0.3	1.4	0.4	0.3	0.4	0.3	-0.3	1.2	-0.2
Ever taken oral contraceptive pill	1.9	2.1	5.5	-1.4	-2.4	-2.3	-0.1	1.2	0.2	-0.8
Hearing aid user	1.3	1.5	4.4	2.1	0.1	0.4	0.8	-1.5	0.3	1.6
Mother’s age at death	0.6	0.7	2.3	-1.2	1.5	-0.5	0.9	0.2	0.1	0.0
Financial situation satisfaction	0.5	0.6	1.9	1.4	-0.3	-0.3	0.7	-1.1	0.2	0.9
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.0	1.0	0.7	0.9	0.2	-1.1	1.4	0.8
Commuting to job workplace: Public transport	1.8	2.2	4.9	-1.1	-1.4	-1.7	-0.4	2.2	-1.0	-1.8
Eye problems/disorders: Glaucoma	1.5	1.8	6.0	0.5	2.4	1.3	0.2	-1.1	1.7	0.8
Medication: Blood pressure	0.1	0.3	0.7	-0.7	-0.4	-0.8	-0.7	-0.1	-0.2	-0.1
Pain type(s) experienced in last month: Hip pain	6.4	8.0	14.7	3.2	2.6	2.2	2.1	-3.4	1.7	3.8
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.7	0.4	0.4	-1.0	1.3	-0.4	0.5	0.8
High cholesterol (Self-reported)	0.3	0.6	1.4	-0.5	0.9	1.2	-0.9	0.1	0.5	-0.5
Medication: Bendroflumethiazide	0.1	0.2	1.2	-0.2	-1.1	-0.1	-0.2	-0.0	-0.0	-0.2
Medication: Paracetamol	0.5	0.8	1.9	-0.9	0.6	-0.5	1.2	1.4	1.0	-0.4
Medication: Lisinopril	0.6	0.8	1.7	-1.2	0.5	-0.7	0.7	1.3	-0.6	-0.9
Medication: Atorvastatin	1.4	1.7	6.8	1.5	-0.7	1.0	0.9	-0.7	2.6	0.5
Illnesses of father: High blood pressure	6.3	7.7	16.2	-4.0	-0.4	-2.2	-1.1	3.7	-2.4	-3.5
Alcohol drinker status: Never	0.6	0.8	2.2	-1.0	-0.6	-0.3	1.5	0.9	-0.2	-0.8
Ever smoked	1.1	2.0	3.2	1.4	1.8	1.1	1.5	-1.7	0.1	1.7
Basal metabolic rate	1.5	8.3	14.3	2.8	2.9	-0.6	3.0	-3.8	2.8	3.3
Leg fat percentage (left)	0.4	1.6	4.5	0.2	2.1	-0.4	1.3	-1.1	1.1	1.6
Arm fat-free mass (left)	1.4	6.9	11.4	2.4	3.0	-0.7	2.5	-3.4	2.7	2.9
Number of operations (self-reported)	0.2	0.4	0.8	-0.1	0.9	0.4	-0.2	-0.8	0.4	0.8
Average weekly beer plus cider intake	0.2	0.3	1.3	1.1	0.6	0.1	0.5	-0.4	0.5	-0.0
Irritability	3.3	5.6	10.9	-2.2	-2.3	-1.3	-1.9	3.2	-1.5	-3.3
Risk taking	0.3	0.4	1.1	-1.0	0.7	0.6	0.7	0.6	-0.1	-0.3
Ever had prostate specific antigen (PSA) test	1.6	1.8	3.6	-1.9	1.0	-1.8	1.6	1.0	1.0	-0.3
Fractured/broken bones in last 5 years	0.9	1.1	2.7	-0.3	0.0	-0.6	-1.6	1.4	-0.8	-1.4
Age started oral contraceptive pill	0.5	0.6	1.5	-1.1	0.4	1.1	0.2	0.2	1.2	-0.2
Diastolic blood pressure, automated reading	1.6	4.9	13.0	-2.2	-1.9	-3.6	-1.9	1.4	-1.8	-1.9
Ever depressed for a whole week	1.6	2.0	4.5	-1.1	-0.7	-0.1	-1.0	1.7	-2.1	-1.9
Unable to work because of sickness or disability	1.2	1.5	2.9	-1.5	-0.2	-1.7	-0.7	1.4	1.1	-1.4
Commuting to job workplace: Cycle	0.3	0.4	1.8	0.6	0.9	0.1	1.3	-0.2	-0.0	0.1
Myopia	0.3	0.4	1.0	-0.6	-0.4	-0.8	1.0	0.2	0.8	-0.1
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.0	1.0	-0.8	0.3	-1.0	0.4	-0.9	-0.6
Cholesterol lowering medication	0.3	0.4	1.2	-0.2	1.1	-0.3	-1.0	0.3	0.4	-0.4
Medication: Omeprazole (e.g. Zanprol)	3.0	3.7	9.1	1.9	0.6	1.6	2.3	-1.5	3.0	1.6
Pain experienced in last month	0.3	0.5	0.9	-0.4	0.7	0.9	-0.8	0.5	0.5	-0.9
Supplements: Calcium	0.4	0.4	1.2	-0.0	0.7	0.7	-1.1	-0.3	0.2	0.5
Basal cell carcinoma (self-reported)	0.7	0.9	2.2	1.5	0.4	-0.1	0.4	-1.4	0.7	0.9
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.7	0.9	0.5	-0.2	-0.0	-0.9	0.5	0.5
Deep venous thrombosis (DVT) (self-reported)	2.0	2.5	4.7	-1.5	-0.5	0.9	-1.9	1.9	-1.6	-2.2
Heart disease (siblings)	0.8	0.9	2.2	0.2	-1.5	0.2	0.8	-0.9	1.2	1.1
Alcohol drinker status: Previous	1.7	1.9	3.9	2.0	-0.2	1.0	1.4	-1.3	2.0	1.1
Pack years of smoking	0.5	0.8	2.4	0.4	0.1	1.3	-0.5	-0.6	1.6	0.7
Impedance of whole body	3.1	15.5	35.3	-4.2	-4.1	0.9	-3.5	5.9	-2.0	-4.7
Leg fat mass (left)	1.0	3.9	8.7	1.1	2.9	-0.3	1.8	-2.2	1.7	2.5
Arm predicted mass (left)	1.3	6.4	11.6	2.3	2.6	-0.7	2.3	-3.4	2.6	2.9