Hub : Genes

KCNN3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1220 0.0320 2.2e-07 0.036 0.068 0.092 0.092 0.112 3.1e-05 1.0e-08 2.6e-11 2.4e-11 1.7e-13
2 GTEx Esophagus Muscularis 0.1200 0.0530 9.8e-03 -0.001 NA 0.022 NA 0.023 3.6e-01 NA 1.6e-02 NA 1.4e-02
3 GTEx Lung 0.0964 0.0411 4.0e-03 0.013 NA 0.040 NA 0.023 3.0e-02 NA 4.7e-04 NA 7.0e-03
4 GTEx Nerve Tibial 0.1293 0.0419 2.2e-04 0.009 NA 0.058 NA 0.059 6.9e-02 NA 6.5e-05 NA 5.4e-05
5 GTEx Pituitary 0.4150 0.1150 9.5e-05 0.309 NA 0.254 NA 0.285 1.6e-08 NA 4.5e-07 NA 7.4e-08
6 TCGA Lung Adenocarcinoma 0.0605 0.0221 5.1e-04 -0.002 0.030 0.011 NA -0.001 9.7e-01 1.6e-04 1.5e-02 NA 4.4e-01
7 TCGA Prostate Adenocarcinoma 0.0479 0.0232 7.4e-03 0.016 0.002 0.014 NA 0.016 7.1e-03 1.7e-01 1.2e-02 NA 7.0e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 2.9 4.5 11.7 -2.8 -1.2 -0.1 -0.5 3.4 -1.0 -3.1
Bipolar Disorder or Schizophrenia 4.4 10.8 24.7 -4.7 -2.7 -1.9 0.7 5.0 -0.9 -4.2
Depressed Affect (Nagel 2018) 0.9 1.8 4.2 -1.6 -0.5 1.2 -0.6 2.0 -1.4 -1.5
Depression (Nagel 2018) 2.7 4.0 9.9 -2.4 -2.0 -0.6 -1.1 1.9 -3.1 -1.7
Intelligence (Savage-Jansen 2018) 0.3 0.9 2.2 -0.0 1.5 0.7 -1.0 0.9 -1.0 -0.8
Neuroticism (Nagel 2018) 2.9 6.8 14.5 -2.6 -3.3 -0.7 -1.6 3.8 -1.2 -3.3
Schizophrenia (2018) 3.4 7.0 13.5 -3.7 -2.6 -2.4 1.3 3.6 -0.3 -2.9
Schizophrenia vs Biploar Disorder 0.3 0.4 1.6 -0.4 0.8 -1.3 0.5 0.1 0.3 0.2
Worry (Nagel 2018) 2.3 4.8 20.4 -1.0 -4.5 -1.3 -0.7 2.4 0.2 -2.1
Alzheimer’s Disease (in mother) 0.2 0.2 0.6 0.1 -0.7 0.5 0.1 -0.5 -0.6 -0.0
Alzheimer’s Disease (in father) 1.3 1.4 3.3 -1.8 0.5 0.5 -0.2 1.4 -1.5 -1.3
Alzheimer’s Disease (including proxy) 0.4 0.6 1.6 -1.0 -1.3 0.5 0.0 0.5 -0.9 -0.6
Crohns Disease (2017) 1.1 2.5 12.3 0.4 -1.3 3.5 1.3 -0.8 -0.1 0.9
Irritable Bowel Disease (IBD) 1.9 4.5 22.5 1.2 -0.2 4.7 1.6 -1.4 -0.1 1.8
Ulcerative Colitis (UC) 0.9 1.6 9.5 0.5 0.1 3.1 0.3 -0.6 -0.4 1.0
Major Depression (MDD) 1.0 1.2 5.1 -0.1 1.3 2.3 0.8 0.7 -0.4 0.4
Reaction Time 3.5 6.7 15.2 -3.9 -1.5 -1.1 -3.3 2.3 -2.1 -2.7
Verbal and Numeric Reasoning (VNR) 0.4 0.9 4.0 0.4 -0.1 -0.2 -0.6 1.0 -2.0 -0.9
Breast Cancer 1.1 2.6 9.4 0.1 1.9 -3.1 1.5 -1.1 0.2 1.4
Ovarian Cancer 0.1 0.2 0.4 0.6 -0.4 -0.6 -0.4 0.3 0.4 -0.0
Prostate Cancer 7.1 10.0 18.0 -3.3 -0.7 -1.8 -4.0 4.2 -2.2 -4.2
Age at First Birth 0.4 0.5 2.8 -0.7 0.5 0.3 -1.7 0.2 0.1 -0.4
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 2.4 3.3 6.5 1.8 0.6 -1.7 1.9 -2.4 0.4 2.5
Coronary Artery Disease (CAD) 3.7 4.4 10.0 -1.0 -3.2 -2.7 -0.0 2.4 -0.8 -2.5
Crohns Disease (2012) 1.9 3.1 8.6 1.3 -1.1 2.9 1.9 -1.7 -0.1 2.0
Mean Putamen Volume 0.2 0.2 1.2 -0.0 1.1 -0.1 -0.0 -0.1 0.4 -0.2
Fasting Glucose 1.7 2.0 3.7 1.5 1.1 -0.3 1.3 -1.9 1.0 1.9
HbA1C 3.6 4.0 8.3 -0.5 -0.5 -1.3 -2.9 2.7 -1.8 -2.7
HDL Cholesterol 0.5 0.8 4.9 -0.5 -0.6 -2.2 0.1 0.2 -0.0 -0.2
LDL Cholesterol 0.2 0.4 1.8 0.3 -1.4 -0.1 0.3 0.4 -0.1 -0.6
Lupus 0.7 1.1 3.3 -0.1 1.8 0.1 0.1 -1.1 -1.0 1.5
Neuroticism (2016) 3.5 5.0 11.7 -2.3 -3.4 -0.1 -0.7 3.3 -0.6 -2.5
Primary Biliary Cirrhosis 1.7 2.4 4.5 -1.2 -1.6 -0.8 -2.0 1.8 -0.3 -2.1
Rheumatoid Arthritis 1.2 1.7 5.6 1.6 0.9 2.4 1.0 -1.0 -0.6 0.7
Schizophrenia (2014) 3.9 8.6 20.3 -4.5 -2.3 -2.1 0.5 4.2 -0.8 -3.4
Triglycerides 0.3 0.5 1.6 -0.2 0.3 -1.0 1.3 0.5 -0.4 -0.2
Type 2 Diabetes (T2D) (2012) 0.9 1.0 3.3 -0.2 1.6 1.8 -0.1 -0.1 -0.9 0.7
Ulcerative Colitis 1.4 2.1 5.8 1.4 0.7 2.4 1.4 -1.1 -0.4 1.7
Blood Eosinophil Count 1.3 10.3 16.7 -3.3 -1.7 -3.1 -3.7 4.1 -1.4 -4.0
Blood Platelet Count 0.4 4.9 14.4 -1.5 2.1 3.8 -2.1 1.9 -1.5 -1.7
Blood Red Count 0.4 3.6 7.8 2.8 -0.5 1.9 0.9 -2.5 -0.4 2.5
Blood White Count 0.3 1.9 5.3 0.1 -1.5 2.3 -2.1 0.0 -0.8 0.5
Heel T-Score 0.3 2.7 5.1 1.7 0.1 -2.2 1.2 -2.1 -0.7 2.2
BMI 1.6 9.3 16.2 2.4 4.0 0.7 2.1 -4.0 2.6 4.0
Height 0.1 2.2 6.8 2.1 0.3 1.2 0.6 -1.1 2.6 1.1
Waist Hip Ratio (WHR) 1.0 4.3 9.6 -3.0 0.3 3.1 -2.6 2.1 -0.4 -0.6
Systolic Blood Pressure 0.1 0.7 1.5 1.2 -0.1 -1.1 -0.4 -1.1 -0.7 0.7
Smoking Status 0.3 0.8 3.4 -0.2 0.5 1.8 1.0 -0.6 -0.0 0.8
Allergy or Eczema 0.2 0.5 3.2 0.0 1.8 -0.2 0.6 0.4 -0.4 -0.2
Cardiovascular Disease 0.2 0.8 1.8 -0.4 1.3 0.5 1.0 -0.8 0.6 1.2
Hypothyroidism (self reported) 1.3 3.0 6.7 1.4 -1.5 0.3 1.7 -1.6 2.6 2.0
Respiratory disease 0.8 1.9 4.0 -1.5 0.8 0.2 -1.8 2.0 -0.7 -1.6
Type 2 Diabetes (T2D) (2018) 0.5 0.9 3.7 -0.7 -0.8 0.7 -1.9 0.7 0.3 -0.7
Lung FEV1/FVC ratio 0.4 2.3 6.1 2.5 -2.1 -0.7 0.5 -0.1 2.1 -0.5
Lung FVC 0.6 2.9 8.0 1.9 2.8 -0.7 0.2 -2.0 1.4 1.7
Neuroticism 2.0 4.9 12.4 -2.0 -2.9 -0.1 -0.7 3.5 -0.3 -3.0
Chronotype (morning person) 0.4 0.8 2.1 0.9 -1.4 -1.0 -1.0 -0.1 0.3 -0.9
Hair Pigment 0.1 3.2 14.7 1.0 -2.1 3.8 -0.1 -1.3 -0.3 0.7
Tanning 0.0 0.4 0.8 -0.3 0.9 -0.8 0.5 -0.2 0.8 0.5
Hand grip strength (left) 2.3 5.9 11.3 2.9 2.1 0.8 2.5 -2.9 1.6 3.4
Number of treatments/medications taken 0.8 1.4 5.0 0.3 0.3 -0.1 2.2 -0.3 1.9 1.0
Average weekly spirits intake 1.5 1.9 4.5 -1.2 0.1 -1.8 -1.9 -0.4 -2.1 -0.4
Sensitivity / hurt feelings 5.3 9.0 18.7 -3.6 -2.9 -1.5 -2.1 4.3 -1.6 -3.7
Frequency of depressed mood in last 2 weeks 3.4 4.7 8.6 -2.9 -2.5 -0.4 -1.9 2.3 -2.1 -2.2
Hearing difficulty/problems: Yes 0.5 0.8 2.0 1.1 -1.4 -0.5 -0.1 1.2 0.3 -0.7
Relative age of first facial hair 0.3 0.6 2.5 -0.1 1.0 0.9 0.0 0.1 1.6 0.1
Other serious medical condition/disability diagnosed by doctor 0.8 1.1 2.3 -1.2 0.1 1.5 1.0 0.9 1.4 -0.2
Ever used hormone-replacement therapy (HRT) 0.9 1.2 4.2 0.4 -0.7 -2.0 1.1 -0.2 1.3 0.7
Ever had hysterectomy (womb removed) 0.3 0.3 1.5 0.4 -0.8 0.4 -0.2 0.1 -1.2 0.2
Systolic blood pressure, automated reading 0.5 1.4 3.9 1.4 0.3 -1.1 0.1 -2.0 -0.2 1.5
Eye problems/disorders: Diabetes related eye disease 2.9 3.2 7.0 -1.8 -2.0 -1.9 -1.1 1.9 -0.1 -2.6
Angina 0.7 0.9 4.6 -0.4 0.2 0.6 -0.1 -0.6 2.1 0.8
Medication for hormone replacement therapy 0.3 0.3 1.4 -0.3 -1.2 0.5 0.3 -0.0 0.3 0.5
Vitamin and mineral supplements 1.2 1.7 4.0 -0.9 -2.0 -0.9 -1.8 1.0 -0.8 -1.2
Supplements: Zinc 1.1 1.2 6.4 -1.1 -0.1 -0.6 -0.5 0.4 -2.5 -0.2
Medication: Co-codamol 0.6 0.7 3.0 -1.7 0.0 -0.3 -0.3 1.0 0.0 -0.8
Medication: Metformin 0.9 1.3 3.7 -0.9 -1.4 0.3 -1.9 0.8 1.3 -0.7
Diabetes (father) 0.4 0.5 1.8 -1.3 0.2 0.2 -0.0 0.1 -1.2 -0.0
Diabetes (mother) 0.3 0.4 1.9 -0.1 0.5 -0.2 0.3 -0.1 1.4 0.6
Severe depression (siblings) 1.1 1.2 3.5 -1.9 -1.0 -0.5 -0.1 1.1 -0.9 -1.3
Pack years adult smoking proportion 0.3 0.4 1.0 -0.2 -0.3 0.9 -0.9 -0.1 1.0 0.4
Impedance of leg (right) 3.1 15.1 34.6 -4.5 -3.0 1.1 -3.9 5.9 -2.2 -4.6
Leg fat-free mass (left) 1.7 9.0 15.4 3.1 3.1 -0.3 3.2 -3.9 2.5 3.5
Trunk fat percentage 0.2 0.7 2.2 -0.2 1.3 0.1 0.8 -0.1 1.5 0.6
Hand grip strength (right) 1.6 4.3 9.4 3.1 1.4 0.6 1.9 -2.6 0.8 2.7
Townsend deprivation index at recruitment 0.2 0.3 0.8 0.3 0.9 -0.7 0.5 -0.1 0.3 0.6
Current tobacco smoking 0.2 0.3 0.8 -0.7 -0.1 0.9 -0.3 -0.1 -0.5 0.5
Average weekly fortified wine intake 0.7 0.8 1.8 -1.3 -0.9 -0.8 -0.2 1.1 -0.1 -1.1
Maternal smoking around birth 1.1 1.6 4.5 0.1 -1.1 -1.5 1.1 -1.0 2.1 1.1
Fed-up feelings 0.7 1.3 4.3 -1.1 -0.6 0.3 -0.1 2.1 -0.2 -1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.6 0.9 3.1 -0.8 -0.9 0.9 -0.1 0.6 -1.8 -0.6
Relative age voice broke 1.3 2.1 5.8 -0.8 -0.9 -2.4 -1.0 1.8 -0.4 -1.7
Taking other prescription medications 1.7 2.7 7.4 1.3 -0.1 -0.2 2.6 -0.9 2.7 1.4
Age when periods started (menarche) 0.4 0.9 3.1 -0.2 0.7 1.6 0.5 0.2 1.8 0.3
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.6 1.6 0.8 0.1 0.5 -0.6 0.1 1.2
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 1.3 0.7 0.4 -0.2 -0.2 -1.2 0.2 0.8
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 1.5 0.3 0.6 -1.2 -1.1 0.6 -0.9 -0.7
Qualifications: CSEs or equivalent 0.2 0.2 1.0 0.3 -0.4 -0.2 -0.4 0.1 1.0 0.1
Serious illness, injury or assault to yourself 0.3 0.4 1.6 -0.6 -1.2 -0.1 -0.1 0.5 0.5 -0.7
High blood pressure 0.2 0.4 1.3 -1.2 0.5 -0.5 1.0 0.0 0.4 0.3
Hayfever, allergic rhinitis or eczema 0.3 0.6 3.4 -0.4 1.9 -0.3 0.3 0.5 -0.5 -0.4
Multivitamins +/- minerals 1.8 2.3 4.3 0.4 1.9 0.1 2.0 -1.3 2.1 1.7
Stomach or abdominal pain in last month 1.0 1.2 5.1 -2.3 -1.0 -0.5 -0.4 1.0 -0.8 -0.6
Supplements: Glucosamine 0.6 0.8 2.9 0.7 0.7 -1.7 0.9 -0.8 0.2 0.8
Diverticular disease/diverticulitis (self-reported) 1.4 1.7 6.2 0.9 -2.5 -0.4 -2.0 -0.4 -0.1 0.2
Medication: Atenolol 0.6 0.7 1.8 0.8 0.7 -1.3 0.2 -1.1 0.7 0.6
Medication: Levothyroxine sodium 2.3 3.9 11.5 1.7 0.7 1.4 1.0 -1.8 3.4 2.4
Sitting height 0.1 1.0 3.7 -0.1 -0.0 1.6 0.5 -0.0 1.9 0.2
Chronic bronchitis/emphysema (father) 0.7 0.8 2.0 -1.1 0.6 -0.6 -1.4 0.8 -0.2 -1.0
High blood pressure (mother) 1.4 2.0 4.2 -0.8 -0.4 -1.9 0.4 2.0 0.8 -2.0
Body mass index (BMI) 1.2 5.2 8.8 1.7 3.0 -1.0 2.0 -2.9 1.9 2.7
Impedance of leg (left) 3.0 14.7 32.6 -4.5 -3.1 0.8 -3.6 5.7 -2.4 -4.5
Leg predicted mass (left) 1.7 9.0 15.2 3.1 3.1 -0.3 3.2 -3.9 2.5 3.5
Trunk fat mass 0.5 2.3 4.0 0.8 1.8 -0.0 1.8 -1.4 2.0 1.8
Waist circumference 1.2 4.3 8.4 1.3 2.9 1.3 1.3 -2.1 2.6 2.4
Number of incorrect matches in round 0.7 1.1 4.1 -0.5 -0.9 2.0 -0.1 -0.0 1.6 -0.4
Past tobacco smoking 0.9 1.6 3.6 -0.9 -1.2 -1.7 -1.9 0.9 -0.8 -1.0
Alcohol usually taken with meals 0.4 0.7 2.5 0.5 -1.6 -0.4 0.8 0.7 -0.2 -0.8
Nervous feelings 1.7 3.1 11.2 -0.4 -3.4 -1.6 -0.1 1.9 1.1 -1.7
Frequency of tenseness / restlessness in last 2 weeks 3.2 5.0 8.1 -2.6 -2.2 -0.6 -2.5 2.8 -0.9 -2.8
Hearing difficulty/problems with background noise 0.2 0.3 1.5 1.2 0.2 0.6 0.0 0.3 0.3 0.3
Hair/balding pattern: Pattern 2 0.6 0.7 2.2 1.5 0.9 0.1 1.0 -0.9 -0.2 0.5
Had menopause 0.2 0.2 1.2 -1.1 0.1 -0.3 -0.3 0.2 0.2 -0.2
Had other major operations 0.7 0.9 1.9 1.2 -1.0 -0.5 -0.2 -1.4 0.4 1.1
Forced vital capacity (FVC) 0.2 0.8 2.8 1.3 1.7 -0.0 -0.1 -0.8 -0.1 0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 1.9 1.4 0.3 0.1 -0.3 -1.1 0.1 1.1
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.5 -0.9 -0.6 0.3 -0.1 1.2 -0.7 -0.6
Qualifications: None of the above 0.8 1.7 4.8 2.2 -0.8 0.3 -0.1 -1.5 1.4 1.3
Financial difficulties in last 2 years 0.6 0.8 3.2 -0.6 1.8 -0.4 -0.4 0.9 -0.6 -0.5
Mouth/teeth dental problems 0.9 1.4 5.7 0.1 -1.6 -2.4 -0.4 0.8 -0.7 -0.7
Heart attack 0.2 0.3 0.9 0.9 0.2 -0.2 0.0 -0.8 0.4 0.5
Allergy 0.2 0.4 1.2 0.4 -1.1 -0.4 0.4 -0.8 0.2 0.8
Pain all over the body in last month 1.2 1.2 2.7 -0.3 1.5 1.1 1.5 0.0 1.6 0.5
Diabetes (self-reported) 0.5 0.7 1.6 -1.0 -1.1 0.7 -1.3 0.6 0.1 -0.6
Hayfever/allergic rhinitis (self-reported) 1.5 2.0 3.4 1.8 1.4 0.8 1.7 -1.5 0.7 1.5
Medication: Ramipril 0.2 0.2 1.3 0.0 -1.1 0.1 -0.2 0.2 -0.2 0.0
Medication: Simvastatin 0.5 0.7 1.8 -0.8 1.3 0.8 -1.3 -0.2 0.5 0.4
Fluid intelligence score 0.4 0.8 1.9 0.2 0.2 -0.1 -1.4 0.9 -1.4 -1.0
Illnesses of siblings 0.4 0.6 1.1 -0.1 0.4 -0.6 -1.0 0.8 -1.0 -1.0
Neuroticism score 3.2 6.8 14.6 -1.9 -3.8 -0.5 -1.3 3.8 -1.4 -3.3
Weight 1.3 6.5 9.8 2.0 2.7 -0.6 2.6 -3.1 2.9 3.0
Impedance of arm (right) 2.7 12.4 29.4 -3.1 -4.2 0.8 -3.0 5.4 -1.9 -4.3
Arm fat percentage (right) 0.2 0.7 2.6 0.1 1.6 -0.6 0.7 -0.2 1.1 0.5
Trunk fat-free mass 1.4 8.0 15.0 2.8 2.4 -0.6 2.9 -3.9 2.9 3.3
Hip circumference 1.1 4.7 7.0 1.9 2.4 -0.6 2.6 -2.5 2.2 2.4
Time employed in main current job 0.5 0.6 1.1 -0.5 -1.0 0.7 -1.1 0.7 0.3 -0.8
Alcohol intake versus 10 years previously 0.3 0.5 2.2 0.8 -0.4 -0.4 -0.2 -0.3 -1.5 0.3
Father’s age at death 1.0 1.4 4.1 -1.2 0.4 0.2 -0.9 2.0 0.5 -1.8
Worrier / anxious feelings 2.3 4.3 13.1 -1.6 -3.6 -0.8 -1.1 2.3 -0.8 -2.5
Frequency of tiredness / lethargy in last 2 weeks 0.5 0.8 2.6 -1.0 0.1 -1.0 0.2 1.6 -0.0 -0.9
Falls in the last year 0.6 0.8 3.2 -1.2 0.4 -1.8 0.2 0.4 0.9 -0.3
Hair/balding pattern: Pattern 3 1.1 1.7 4.2 -1.6 0.3 -0.8 -0.8 2.1 -1.0 -1.6
Number of live births 0.2 0.3 0.9 0.4 -0.0 -0.8 -0.3 0.3 0.9 0.1
Forced expiratory volume in 1-second (FEV1) 0.3 1.1 5.3 2.3 0.9 -0.9 -0.0 -0.7 0.3 0.2
Pulse rate 2.0 3.4 7.0 -1.2 -2.6 -1.7 -1.3 2.2 0.3 -2.4
Happiness 0.6 0.8 2.0 0.1 -0.4 -0.4 -0.8 1.4 -0.7 -1.4
Noisy workplace 0.6 0.7 2.5 0.7 -0.4 -0.2 0.9 -0.5 1.6 0.7
Qualifications: A levels/AS levels or equivalent 2.7 6.1 13.0 -3.6 0.4 -1.1 -1.2 3.3 -2.8 -2.8
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 2.5 -0.2 -1.3 -0.2 -1.6 -0.1 -0.2 -0.6
Mouth/teeth dental problems: Dentures 1.2 2.0 5.9 0.8 0.5 2.4 0.1 -1.2 2.1 1.1
Asthma 0.5 1.0 2.5 -1.3 -0.9 -0.2 -0.7 1.6 0.2 -1.1
Medication: Ibuprofen (e.g. Nurofen) 0.6 0.8 1.7 -1.0 -0.4 -1.3 -0.4 1.2 -0.3 -0.9
Medication: Cholesterol lowering 1.1 1.6 4.5 0.2 0.6 1.9 0.7 -1.1 2.1 1.1
Depression (self-reported) 0.4 0.4 1.1 0.6 1.1 0.1 0.3 0.3 -1.0 -0.5
Medication: Lansoprazole 1.2 1.4 3.5 1.4 0.5 -0.0 1.2 -1.9 0.2 1.6
Prospective memory result 0.8 1.0 2.8 -0.6 -1.7 -1.3 -0.4 0.3 1.2 -0.7
Lung cancer (father) 2.0 2.3 5.1 1.0 0.8 1.4 1.7 -1.9 1.0 2.3
Illnesses of mother 0.5 0.6 2.0 -0.8 1.4 0.5 0.0 -0.3 -1.0 0.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 7.6 2.8 1.5 -0.5 0.8 -1.2 0.7 0.9
Pulse wave Arterial Stiffness index 0.6 0.8 1.6 1.0 0.4 1.3 -0.9 -0.6 -1.0 0.7
Impedance of arm (left) 2.2 10.0 23.6 -3.0 -3.8 1.5 -2.3 4.9 -1.3 -3.7
Arm fat mass (right) 0.7 2.9 5.6 1.0 2.4 -0.8 1.7 -1.7 2.1 1.8
Trunk predicted mass 1.4 7.9 15.0 2.8 2.3 -0.6 2.8 -3.9 2.8 3.3
Standing height 0.1 1.2 5.0 0.7 -0.3 0.8 1.0 -0.8 2.2 0.9
Length of working week for main job 0.2 0.2 1.4 -0.3 -0.3 1.2 0.1 -0.0 -0.2 0.1
Exposure to tobacco smoke at home 0.4 0.4 1.9 0.1 -0.1 -0.8 -1.4 -0.0 -0.7 0.1
Breastfed as a baby 3.3 4.1 6.7 1.6 2.6 0.8 1.3 -2.3 2.4 2.4
Tense / ‘highly strung’ 1.7 2.8 6.6 -2.0 -1.8 -0.7 -0.2 2.6 0.2 -2.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.8 2.8 0.2 -0.8 -0.9 -0.3 1.3 -0.2 -1.7
Hair/balding pattern: Pattern 4 0.5 1.2 2.5 1.5 1.6 -0.5 -0.6 -1.0 1.2 0.7
Birth weight of first child 3.9 7.1 16.6 2.4 3.2 4.1 1.2 -2.7 1.3 2.6
Peak expiratory flow (PEF) 0.7 1.6 6.1 2.5 -0.7 -2.1 0.3 -0.1 -0.1 -0.3
Pulse wave reflection index 1.5 1.9 4.2 1.0 1.1 2.0 -0.2 -1.9 -0.6 1.6
Ever highly irritable/argumentative for 2 days 0.8 0.9 2.0 -0.7 1.1 0.3 -0.0 1.3 -1.4 -1.1
Loud music exposure frequency 1.8 1.9 4.6 -1.5 -2.1 -0.8 -0.8 1.6 -1.1 -1.2
Qualifications: O levels/GCSEs or equivalent 3.3 5.3 10.1 -3.1 -0.7 -1.1 -1.2 2.7 -3.2 -2.6
Mouth/teeth dental problems: Bleeding gums 1.4 1.8 7.4 -0.3 1.8 2.7 0.2 -0.7 -1.0 0.8
Blood clot in the leg (DVT) 1.8 2.4 4.8 -1.4 -0.5 1.0 -1.6 2.0 -1.4 -2.2
Medication: Paracetamol 0.3 0.5 1.5 -0.6 -0.2 -0.7 0.8 1.2 0.5 -0.5
Headache pain in last month 0.8 1.4 3.2 -0.9 -1.0 -0.8 -0.1 1.8 -0.9 -1.7
Medication for cholesterol, blood pressure or diabetes 0.5 0.8 1.8 0.4 -0.1 -1.3 -1.2 0.7 -0.8 -0.9
Glaucoma (self-reported) 1.5 1.7 6.1 1.2 2.5 0.9 -0.7 -1.2 1.1 0.9
Gout (self-reported) 4.2 5.8 13.8 2.1 1.6 0.8 2.3 -3.7 0.5 3.6
Hypothyroidism/myxoedema (self-reported) 2.0 3.9 8.6 1.6 0.0 0.9 1.9 -2.1 2.9 2.6
Medication: Amlodipine 0.1 0.1 0.3 -0.5 -0.3 0.3 -0.5 -0.4 -0.1 0.4
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.5 0.5 -0.7 -0.1 -0.4 0.5 0.3 -0.3
Birth weight 3.0 6.6 14.4 2.1 2.6 3.8 1.1 -2.9 0.8 3.1
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.5 -0.6 -0.9 -1.2 -0.2 0.7 -1.2 -0.2
High blood pressure (siblings) 0.6 0.9 4.0 -2.0 0.1 -0.1 -0.6 1.1 -0.0 -0.7
Forced vital capacity (FVC), Best measure 0.6 2.3 6.3 2.1 2.5 0.3 0.8 -1.4 0.7 1.3
Body fat percentage 0.2 0.9 3.1 -0.1 1.8 -0.1 0.9 -0.3 1.4 0.8
Leg fat percentage (right) 0.4 1.4 4.6 0.0 2.1 -0.3 1.1 -0.8 1.2 1.4
Arm fat-free mass (right) 1.7 8.8 16.6 2.6 2.9 -0.3 2.9 -4.1 3.0 3.5
Exposure to tobacco smoke outside home 0.8 1.0 2.4 -0.2 -0.7 0.4 -1.4 1.4 -0.5 -1.6
Comparative body size at age 10 0.3 0.8 3.5 0.6 1.9 -0.6 -0.1 -0.9 -0.8 0.1
Number of full brothers 0.4 0.5 0.7 0.8 -0.5 -0.8 -0.2 -0.8 -0.7 0.8
Worry too long after embarrassment 3.2 5.4 12.4 -1.2 -2.6 -0.5 -2.3 3.5 -0.6 -3.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.1 3.8 -0.6 -1.0 1.9 -0.6 0.9 -0.1 -1.0
Wheeze or whistling in the chest in last year 0.4 0.7 2.0 -1.4 -0.2 0.8 0.1 1.4 0.0 -0.7
Number of children fathered 2.2 2.5 6.2 2.5 1.0 -1.3 1.0 -2.1 1.0 1.6
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 1.3 -0.4 -1.1 -0.4 -0.7 -0.4 -0.6 -0.4
Age at first live birth 0.1 0.2 0.6 -0.8 -0.3 0.6 0.2 -0.2 0.3 -0.2
Pulse wave peak to peak time 0.6 0.7 1.4 -1.1 -0.4 -1.2 0.8 0.6 0.9 -0.8
Health satisfaction 0.8 1.0 2.3 1.5 0.7 -0.5 1.1 -0.5 1.3 0.9
Shortness of breath walking on level ground 3.2 3.8 11.8 2.0 0.9 -0.6 3.4 -1.2 2.4 1.7
Qualifications: College or University degree 1.1 3.4 7.0 -1.7 -1.2 -1.8 -1.1 2.5 -1.2 -2.6
Eye problems/disorders: None of the above 0.9 1.0 5.6 0.4 -0.9 -2.4 -0.3 0.3 -0.4 -0.1
Mouth/teeth dental problems: Loose teeth 0.8 0.9 1.8 -1.3 -0.8 -0.7 -1.1 0.2 -1.3 -0.6
Emphysema/chronic bronchitis 2.4 2.7 5.4 -1.8 -0.1 1.8 -2.3 1.9 -0.7 -1.7
Medication for pain relief, constipation, heartburn 0.9 1.5 5.2 0.0 0.1 0.7 -2.3 -0.4 -2.2 -0.2
Neck or shoulder pain in last month 0.7 1.0 3.1 -1.1 -0.4 -1.8 -0.0 1.0 -0.8 -0.8
Medication: Blood pressure 0.3 0.5 2.0 0.2 0.4 0.4 1.4 -0.6 0.3 0.9
Angina (self-reported) 0.5 0.7 3.9 -0.2 -0.0 0.3 0.1 -0.6 2.0 0.7
Migraine (self-reported) 1.2 1.5 5.0 -0.5 0.4 -0.8 -0.7 2.2 -0.9 -1.8
Medication: Ibuprofen 0.6 0.7 2.6 -0.9 0.6 -1.6 -0.5 0.8 -0.4 -0.7
Medication: Allopurinol 4.7 6.2 17.5 2.2 0.8 0.3 1.9 -4.2 1.1 3.9
Medication: Omeprazole 2.2 2.6 8.2 1.1 1.0 1.2 2.0 -1.1 2.9 1.2
Medication: Seretide 50 evohaler 0.4 0.5 1.0 0.6 -0.8 0.4 0.2 -0.8 0.8 1.0
Mean time to correctly identify matches 3.9 7.4 18.4 -4.3 -1.9 -1.3 -3.2 2.4 -2.2 -2.7
Heart disease (mother) 1.5 1.8 4.5 1.6 -0.9 1.1 -0.6 -1.5 2.1 1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.5 4.2 8.9 3.0 -0.2 0.8 2.4 -1.9 2.8 1.7
Whole body fat mass 0.7 3.1 5.5 1.1 2.3 -0.2 1.8 -1.8 2.1 2.0
Leg fat mass (right) 1.0 3.7 8.6 1.1 2.9 -0.3 1.8 -2.1 1.7 2.4
Arm predicted mass (right) 1.8 9.4 18.0 2.6 3.0 -0.2 3.1 -4.2 2.9 3.7
Pulse rate, automated reading 2.1 6.7 12.5 -3.2 -2.2 -1.2 -2.4 3.5 0.0 -3.4
Alcohol intake frequency. 0.4 0.9 2.1 -1.1 1.0 0.4 0.2 1.4 0.5 -1.2
Comparative height size at age 10 0.9 4.7 10.0 2.0 -0.4 0.7 2.3 -3.1 1.9 3.2
Number of full sisters 0.7 0.8 1.4 0.5 -1.1 -1.2 1.1 -0.7 0.8 0.7
Suffer from ‘nerves’ 2.0 3.1 12.7 -0.7 -3.6 -1.0 -0.9 1.7 -1.1 -1.6
Overall health rating 0.5 1.0 1.8 -1.3 -1.3 -1.0 0.1 1.3 0.4 -0.9
Chest pain or discomfort 0.3 0.5 1.5 -0.2 -0.3 1.2 0.8 -0.5 0.0 0.8
Had major operations 1.1 1.3 3.7 1.1 1.3 0.7 0.7 -0.7 1.9 0.9
Age at last live birth 0.7 1.0 1.7 -1.3 1.1 1.1 -0.7 0.7 1.2 -0.7
Family relationship satisfaction 0.8 1.0 2.5 -0.6 -0.8 -0.0 -0.6 1.3 -1.1 -1.6
Leg pain on walking 0.4 0.5 2.6 -0.0 1.6 -0.0 1.0 0.1 0.5 0.1
Qualifications: NVQ or HND or HNC or equivalent 4.2 5.1 8.0 1.4 2.6 1.4 2.3 -2.8 2.2 2.6
Commuting to job workplace: Car/motor vehicle 0.7 0.8 2.1 1.3 0.6 -0.3 0.5 -1.4 0.4 1.1
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 3.7 1.9 0.6 0.8 1.1 -0.6 -0.4 0.6
Medication: Aspirin 2.1 2.8 10.3 0.5 -0.0 1.4 2.3 -0.9 3.2 1.2
Supplements: Vitamin C 0.5 0.5 1.2 -0.8 0.8 0.2 0.3 0.8 -1.1 -0.8
Knee pain experienced in last month 1.0 1.5 3.7 1.3 0.8 -0.6 0.4 -1.9 0.7 1.9
Hypertension (Self-reported) 0.2 0.6 2.2 -1.2 0.3 -0.1 1.5 -0.1 0.3 0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.1 2.5 6.2 1.4 0.0 -0.3 1.6 -2.5 1.6 2.0
Illnesses of father: Heart disease 0.5 0.7 1.7 -0.8 -0.9 -1.0 -0.3 0.3 1.3 -0.8
Illnesses of siblings: Diabetes 0.9 1.2 3.8 -1.5 0.4 -2.0 0.8 0.7 -0.1 -0.9
Smoking status: Previous 2.4 3.6 6.8 1.7 1.8 2.6 2.4 -1.6 1.0 1.7
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.7 1.8 0.3 0.2 0.4 1.2 -1.1 -0.7 1.3
Whole body fat-free mass 1.6 9.1 16.6 3.0 2.9 -0.6 3.1 -4.1 2.8 3.5
Leg fat-free mass (right) 1.7 9.1 16.8 3.2 2.7 -0.6 3.3 -4.1 2.3 3.5
Arm fat percentage (left) 0.3 1.1 2.9 0.4 1.7 -0.3 1.1 -0.7 1.4 1.0
Average weekly red wine intake 0.4 0.6 1.2 0.9 0.2 -0.1 0.9 -1.1 0.8 0.8
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.1 -0.2 -0.6 -0.9 1.1 -0.1 1.0 0.2
Mood swings 2.8 5.1 9.4 -2.0 -2.0 1.1 -2.3 3.1 -1.9 -2.8
Loneliness, isolation 0.5 0.7 3.2 -0.5 -1.8 0.6 0.1 0.7 -0.9 -0.4
Long-standing illness, disability or infirmity 0.5 0.8 2.9 1.1 0.3 0.6 1.7 -0.4 0.5 0.9
Ever had bowel cancer screening 1.7 2.0 12.3 0.2 3.5 0.6 -0.3 -0.7 0.3 0.7
Diabetes diagnosed by doctor 0.7 1.2 2.5 -1.1 -1.0 0.6 -1.6 1.0 1.1 -1.1
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.5 0.9 -0.5 -0.7 0.2 0.6 0.7 -0.7 -1.0
Friendships satisfaction 1.3 1.6 4.3 -1.0 -0.5 -0.9 -0.1 2.1 -1.3 -1.8
Qualifications: nursing, teaching 0.5 0.8 2.8 -0.3 1.7 -0.7 -0.5 1.0 -0.1 -1.0
Commuting to job workplace: Walk 0.5 0.5 1.4 -1.1 0.7 0.3 0.6 0.5 -1.2 -0.1
Eye problems/disorders: Cataract 0.6 0.7 1.5 -1.2 0.2 1.0 0.9 -0.8 0.5 0.6
Mouth/teeth dental problems: Mouth ulcers 0.2 0.4 1.9 -0.2 1.4 0.1 -0.0 -0.5 0.7 0.2
Medication for cholesterol 0.2 0.3 0.7 0.8 -0.1 0.5 0.9 -0.0 -0.5 -0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.3 0.8 -0.1 -0.5 -0.8 0.9 0.6 -0.0 -0.1
Back pain experienced in last month 0.3 0.5 1.3 1.0 -1.1 -0.8 -0.2 -0.4 0.1 0.3
Mineral and other dietary supplements 0.4 0.5 2.9 -0.2 -0.4 1.7 -0.2 0.2 -0.5 -0.5
Breast cancer (self-reported) 1.1 1.3 5.5 -2.3 1.0 -1.1 -0.4 0.8 0.2 -0.6
Asthma (self-reported) 0.6 1.3 2.8 -1.3 -1.2 -0.3 -0.9 1.7 -0.1 -1.4
Osteoporosis (self-reported) 0.7 0.9 2.2 -0.9 -0.2 -0.4 -0.6 1.5 -0.4 -1.5
Osteoarthritis (self-reported) 1.2 1.5 3.8 1.4 0.7 0.2 1.3 -1.9 0.8 1.6
Medication: Aspirin 1.8 2.4 9.8 0.5 0.1 1.1 2.0 -0.7 3.1 1.1
Medication: Gliclazide 1.1 1.2 2.6 -0.8 -1.4 0.8 -1.0 1.6 0.3 -1.1
Illnesses of father: None of the above (group 1) 2.6 3.2 9.8 3.1 1.0 0.9 0.4 -2.3 0.7 2.3
Smoking status: Current 0.2 0.3 0.7 -0.8 -0.6 0.2 -0.6 0.4 -0.6 -0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 6.4 2.5 1.5 0.1 0.8 -1.4 0.1 0.9
Whole body water mass 1.6 9.2 16.8 3.0 2.9 -0.6 3.1 -4.1 2.9 3.5
Leg predicted mass (right) 1.7 9.3 17.3 3.2 2.8 -0.5 3.4 -4.2 2.3 3.6
Arm fat mass (left) 0.8 3.1 4.9 1.2 2.2 -0.6 1.8 -1.8 2.1 2.0
Number of self-reported non-cancer illnesses 0.3 0.6 1.0 0.2 0.6 1.0 0.9 -0.7 1.0 0.8
Average weekly champagne plus white wine intake 1.1 1.5 3.0 -0.8 -1.5 -1.3 -1.7 1.1 -0.1 -1.4
Miserableness 1.5 2.7 8.2 -1.9 -0.5 -0.0 -0.2 2.9 -0.9 -2.4
Guilty feelings 2.0 3.0 7.5 -1.1 -1.9 -1.4 0.4 2.5 -0.8 -2.7
Wears glasses or contact lenses 0.3 0.3 1.4 0.4 0.3 0.4 0.3 -0.3 1.2 -0.2
Ever taken oral contraceptive pill 1.9 2.1 5.5 -1.4 -2.4 -2.3 -0.1 1.2 0.2 -0.8
Hearing aid user 1.3 1.5 4.4 2.1 0.1 0.4 0.8 -1.5 0.3 1.6
Mother’s age at death 0.6 0.7 2.3 -1.2 1.5 -0.5 0.9 0.2 0.1 0.0
Financial situation satisfaction 0.5 0.6 1.9 1.4 -0.3 -0.3 0.7 -1.1 0.2 0.9
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.0 1.0 0.7 0.9 0.2 -1.1 1.4 0.8
Commuting to job workplace: Public transport 1.8 2.2 4.9 -1.1 -1.4 -1.7 -0.4 2.2 -1.0 -1.8
Eye problems/disorders: Glaucoma 1.5 1.8 6.0 0.5 2.4 1.3 0.2 -1.1 1.7 0.8
Medication: Blood pressure 0.1 0.3 0.7 -0.7 -0.4 -0.8 -0.7 -0.1 -0.2 -0.1
Pain type(s) experienced in last month: Hip pain 6.4 8.0 14.7 3.2 2.6 2.2 2.1 -3.4 1.7 3.8
Supplements: Fish oil (including cod liver oil) 0.4 0.6 1.7 0.4 0.4 -1.0 1.3 -0.4 0.5 0.8
High cholesterol (Self-reported) 0.3 0.6 1.4 -0.5 0.9 1.2 -0.9 0.1 0.5 -0.5
Medication: Bendroflumethiazide 0.1 0.2 1.2 -0.2 -1.1 -0.1 -0.2 -0.0 -0.0 -0.2
Medication: Paracetamol 0.5 0.8 1.9 -0.9 0.6 -0.5 1.2 1.4 1.0 -0.4
Medication: Lisinopril 0.6 0.8 1.7 -1.2 0.5 -0.7 0.7 1.3 -0.6 -0.9
Medication: Atorvastatin 1.4 1.7 6.8 1.5 -0.7 1.0 0.9 -0.7 2.6 0.5
Illnesses of father: High blood pressure 6.3 7.7 16.2 -4.0 -0.4 -2.2 -1.1 3.7 -2.4 -3.5
Alcohol drinker status: Never 0.6 0.8 2.2 -1.0 -0.6 -0.3 1.5 0.9 -0.2 -0.8
Ever smoked 1.1 2.0 3.2 1.4 1.8 1.1 1.5 -1.7 0.1 1.7
Basal metabolic rate 1.5 8.3 14.3 2.8 2.9 -0.6 3.0 -3.8 2.8 3.3
Leg fat percentage (left) 0.4 1.6 4.5 0.2 2.1 -0.4 1.3 -1.1 1.1 1.6
Arm fat-free mass (left) 1.4 6.9 11.4 2.4 3.0 -0.7 2.5 -3.4 2.7 2.9
Number of operations (self-reported) 0.2 0.4 0.8 -0.1 0.9 0.4 -0.2 -0.8 0.4 0.8
Average weekly beer plus cider intake 0.2 0.3 1.3 1.1 0.6 0.1 0.5 -0.4 0.5 -0.0
Irritability 3.3 5.6 10.9 -2.2 -2.3 -1.3 -1.9 3.2 -1.5 -3.3
Risk taking 0.3 0.4 1.1 -1.0 0.7 0.6 0.7 0.6 -0.1 -0.3
Ever had prostate specific antigen (PSA) test 1.6 1.8 3.6 -1.9 1.0 -1.8 1.6 1.0 1.0 -0.3
Fractured/broken bones in last 5 years 0.9 1.1 2.7 -0.3 0.0 -0.6 -1.6 1.4 -0.8 -1.4
Age started oral contraceptive pill 0.5 0.6 1.5 -1.1 0.4 1.1 0.2 0.2 1.2 -0.2
Diastolic blood pressure, automated reading 1.6 4.9 13.0 -2.2 -1.9 -3.6 -1.9 1.4 -1.8 -1.9
Ever depressed for a whole week 1.6 2.0 4.5 -1.1 -0.7 -0.1 -1.0 1.7 -2.1 -1.9
Unable to work because of sickness or disability 1.2 1.5 2.9 -1.5 -0.2 -1.7 -0.7 1.4 1.1 -1.4
Commuting to job workplace: Cycle 0.3 0.4 1.8 0.6 0.9 0.1 1.3 -0.2 -0.0 0.1
Myopia 0.3 0.4 1.0 -0.6 -0.4 -0.8 1.0 0.2 0.8 -0.1
Vascular/heart problems diagnosed by doctor 0.2 0.6 1.0 1.0 -0.8 0.3 -1.0 0.4 -0.9 -0.6
Cholesterol lowering medication 0.3 0.4 1.2 -0.2 1.1 -0.3 -1.0 0.3 0.4 -0.4
Medication: Omeprazole (e.g. Zanprol) 3.0 3.7 9.1 1.9 0.6 1.6 2.3 -1.5 3.0 1.6
Pain experienced in last month 0.3 0.5 0.9 -0.4 0.7 0.9 -0.8 0.5 0.5 -0.9
Supplements: Calcium 0.4 0.4 1.2 -0.0 0.7 0.7 -1.1 -0.3 0.2 0.5
Basal cell carcinoma (self-reported) 0.7 0.9 2.2 1.5 0.4 -0.1 0.4 -1.4 0.7 0.9
Heart attack/myocardial infarction (self-reported) 0.2 0.3 0.7 0.9 0.5 -0.2 -0.0 -0.9 0.5 0.5
Deep venous thrombosis (DVT) (self-reported) 2.0 2.5 4.7 -1.5 -0.5 0.9 -1.9 1.9 -1.6 -2.2
Heart disease (siblings) 0.8 0.9 2.2 0.2 -1.5 0.2 0.8 -0.9 1.2 1.1
Alcohol drinker status: Previous 1.7 1.9 3.9 2.0 -0.2 1.0 1.4 -1.3 2.0 1.1
Pack years of smoking 0.5 0.8 2.4 0.4 0.1 1.3 -0.5 -0.6 1.6 0.7
Impedance of whole body 3.1 15.5 35.3 -4.2 -4.1 0.9 -3.5 5.9 -2.0 -4.7
Leg fat mass (left) 1.0 3.9 8.7 1.1 2.9 -0.3 1.8 -2.2 1.7 2.5
Arm predicted mass (left) 1.3 6.4 11.6 2.3 2.6 -0.7 2.3 -3.4 2.6 2.9