TWAS hub - CYP1A1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Brain Lower Grade Glioma	0.0636	0.0333	0.00015	0.058	0.046	0.044	NA	0.053	3.5e-07	5.9e-06	8.6e-06	NA	1.1e-06
2	TCGA	Prostate Adenocarcinoma	0.0614	0.0444	0.00680	0.032	0.023	0.033	NA	0.023	2.6e-04	1.7e-03	1.9e-04	NA	1.8e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Illnesses of father: None of the above (group 1)	5.9	7.2	10.7	1.9	-3.3
Exposure to tobacco smoke outside home	4.3	5.7	9.1	-1.6	3.0
Mouth/teeth dental problems: Mouth ulcers	4.3	6.9	7.1	2.7	-2.6
Leg fat percentage (right)	4.2	15.4	27.5	-1.8	5.2
Leg pain on walking	4.1	5.1	5.1	-2.3	2.3
Knee pain experienced in last month	4.1	6.4	9.5	-1.8	3.1
Average weekly beer plus cider intake	4.1	6.0	11.9	0.2	-3.5
Diastolic blood pressure, automated reading	4.1	12.8	16.1	-3.1	4.0
Alcohol intake versus 10 years previously	4.0	6.0	12.0	-0.1	-3.5
Medication: Ibuprofen	4.0	4.7	4.9	-2.2	2.1
Pulse rate, automated reading	4.0	12.8	13.5	-3.5	3.7
Impedance of arm (right)	3.9	18.2	27.9	2.9	-5.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.7	4.4	6.1	1.6	-2.5
Health satisfaction	3.6	4.7	4.7	-2.2	2.1
Leg fat mass (right)	3.6	14.1	21.3	-2.6	4.6
Leg fat percentage (left)	3.6	12.9	23.4	-1.5	4.8
Supplements: Calcium	3.6	4.0	7.5	0.7	-2.7
Medication: Paracetamol	3.5	5.3	6.2	-2.5	2.1
Commuting to job workplace: Cycle	3.5	4.3	5.9	2.4	-1.6
Relative age voice broke	3.4	5.2	5.5	2.2	-2.4
Mother’s age at death	3.4	4.2	5.3	2.3	-1.8
Commuting to job workplace: Car/motor vehicle	3.3	3.7	5.6	-2.4	1.4
Supplements: Vitamin C	3.3	3.9	7.2	0.8	-2.7
Impedance of arm (left)	3.2	15.0	22.2	2.8	-4.7
Heart disease (mother)	3.2	3.9	4.3	-2.1	1.9
Bipolar Disorder (2018)	3.1	5.0	7.0	-1.7	2.6
Alzheimer’s Disease (in father)	3.0	3.3	3.6	-1.7	1.9
Hand grip strength (left)	3.0	7.9	15.7	-4.0	-0.0
Number of treatments/medications taken	3.0	5.4	8.2	-1.6	2.9
Leg fat mass (left)	3.0	11.9	18.6	-2.3	4.3
Ever unenthusiastic/disinterested for a whole week	2.9	3.5	6.7	-2.6	0.6
Blood Platelet Count	2.8	32.3	50.0	-3.8	7.1
Overall health rating	2.8	6.1	8.3	-2.0	2.9
Medication: Atenolol	2.7	3.4	4.5	-1.5	2.1
Sitting height	2.7	19.2	37.8	-6.2	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.7	4.1	4.6	-1.9	2.1
Medication: Paracetamol	2.7	4.5	4.9	-2.2	2.0
Ever used hormone-replacement therapy (HRT)	2.6	3.3	4.0	2.0	-1.6
Schizophrenia vs Biploar Disorder	2.5	3.3	5.8	1.0	-2.4
Major Depression (MDD)	2.5	3.0	4.5	-2.1	1.3
Body mass index (BMI)	2.5	10.8	18.9	-1.7	4.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.5	2.9	3.9	-1.4	2.0
Depression (self-reported)	2.4	2.9	5.3	-0.7	2.3
BMI	2.3	13.1	24.6	-1.2	5.0
Type 2 Diabetes (T2D) (2018)	2.3	4.4	7.0	-1.3	2.6
Systolic blood pressure, automated reading	2.3	6.7	11.1	-1.5	3.3
Pulse wave peak to peak time	2.3	2.7	4.6	0.9	-2.2
Family relationship satisfaction	2.3	2.8	3.5	-1.9	1.4
Happiness	2.2	2.7	3.0	-1.7	1.6
Ulcerative Colitis	2.1	3.0	3.6	-1.9	1.6
Forced vital capacity (FVC)	2.1	8.2	14.9	-3.9	-1.2
Medication: Blood pressure	2.1	3.7	5.8	-1.3	2.4
Average weekly champagne plus white wine intake	2.1	2.9	4.1	-1.3	2.0
Guilty feelings	2.1	3.1	4.3	-1.4	-2.1
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.5	3.3	-1.3	1.8
Arm fat-free mass (right)	2.0	10.5	13.5	-3.7	2.7
Osteoporosis (self-reported)	2.0	2.5	3.7	1.1	-1.9
Vitamin and mineral supplements	1.9	2.5	4.8	0.5	2.2
Had menopause	1.9	2.3	3.2	1.8	-1.2
Forced expiratory volume in 1-second (FEV1)	1.9	6.5	12.5	-3.5	-0.7
Pulse rate	1.9	3.2	5.4	-2.3	1.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.9	6.1	11.8	-3.4	-0.7
Forced vital capacity (FVC), Best measure	1.9	7.1	13.1	-3.6	-1.0
Loneliness, isolation	1.9	2.6	5.1	-2.2	-0.4
Pulse wave Arterial Stiffness index	1.8	2.1	3.6	-0.8	1.9
Arm predicted mass (right)	1.8	9.0	10.6	-3.3	2.7
Osteoarthritis (self-reported)	1.8	2.4	4.7	-0.2	2.2
Alcohol drinker status: Previous	1.8	2.0	3.7	-1.9	0.6
Blood Eosinophil Count	1.7	13.3	13.6	3.6	-3.7
Other serious medical condition/disability diagnosed by doctor	1.7	2.2	4.4	-2.1	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	1.7	2.3	3.5	-1.9	1.0
Diabetes (self-reported)	1.7	2.6	4.3	-0.9	2.1
Medication: Simvastatin	1.7	2.6	2.6	-1.6	1.6
Weight	1.7	8.4	9.1	-3.0	2.8
Hair/balding pattern: Pattern 4	1.7	4.1	5.2	-2.3	1.7
Peak expiratory flow (PEF)	1.7	4.0	7.7	0.6	-2.8
Body fat percentage	1.7	6.7	12.0	-1.2	3.5
Commuting to job workplace: Walk	1.7	1.8	2.4	1.1	-1.6
Ever depressed for a whole week	1.7	2.2	3.9	-2.0	0.6
Impedance of whole body	1.7	8.4	12.2	2.1	-3.5
Hand grip strength (right)	1.6	4.4	6.2	-2.5	-1.6
Waist circumference	1.6	5.8	8.8	-1.7	3.0
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.5	3.0	-1.4	1.7
Number of live births	1.6	2.2	4.1	-0.5	-2.0
Mouth/teeth dental problems: Dentures	1.6	2.8	4.6	-1.0	2.1
Whole body fat mass	1.6	6.7	10.1	-1.8	3.2
Suffer from ‘nerves’	1.6	2.5	3.0	1.7	-1.4
Handedness (chirality/laterality): Left-handed	1.6	1.9	3.8	0.3	1.9
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	2.7	-1.6	-0.9
Average weekly spirits intake	1.5	1.9	3.7	0.3	1.9
Frequency of depressed mood in last 2 weeks	1.5	2.1	3.3	-1.8	0.9
Chronic bronchitis/emphysema (father)	1.5	1.7	2.7	-1.6	0.9
Lung cancer (father)	1.5	1.7	2.0	1.4	-1.2
Arm fat mass (left)	1.5	6.0	9.9	-1.5	3.1
Hip circumference	1.4	6.2	6.3	-2.5	2.5
Gout (self-reported)	1.4	1.9	3.7	-0.4	-1.9
Mouth/teeth dental problems: Loose teeth	1.4	1.7	2.0	-1.2	1.4
Medication: Allopurinol	1.4	1.9	3.8	-0.0	-2.0
Illnesses of father: Heart disease	1.4	1.9	2.0	-1.3	1.4
Wears glasses or contact lenses	1.4	1.6	1.7	-1.2	1.3
Fasting Glucose	1.3	1.6	2.0	1.4	-1.1
Cardiovascular Disease	1.3	4.3	7.1	-1.2	2.7
Medication: Metformin	1.3	1.9	3.5	-0.5	1.9
Leg fat-free mass (left)	1.3	6.7	9.4	-3.1	2.0
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	2.7	0.5	-1.6
Had major operations	1.3	1.6	1.7	-1.2	1.3
Smoking status: Previous	1.3	1.9	3.1	1.8	-0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.7	5.4	-2.3	0.0
Ever smoked	1.3	2.3	2.7	1.4	-1.6
Arm fat-free mass (left)	1.3	6.7	9.2	-3.0	2.0
Relative age of first facial hair	1.2	2.6	4.3	0.9	-2.1
Leg predicted mass (left)	1.2	6.6	9.2	-3.0	2.0
Trunk fat mass	1.2	5.3	7.5	-1.8	2.7
Arm fat mass (right)	1.2	4.9	7.9	-1.4	2.8
Medication for pain relief, constipation, heartburn	1.2	2.1	2.2	1.4	-1.5
Arm fat percentage (left)	1.2	4.8	9.3	-0.5	3.1
Ever had bowel cancer screening	1.2	1.4	2.3	0.7	-1.5
Miserableness	1.2	2.1	4.1	-2.0	0.4
Financial situation satisfaction	1.2	1.5	1.7	-1.2	1.3
Basal metabolic rate	1.2	6.9	9.8	-3.1	2.0
Fractured/broken bones in last 5 years	1.2	1.5	1.6	1.3	-1.2
Arm predicted mass (left)	1.2	5.9	7.8	-2.8	2.0
Depressed Affect (Nagel 2018)	1.1	2.3	4.6	-2.1	0.1
Irritable Bowel Disease (IBD)	1.1	2.6	4.1	-2.0	1.1
Ovarian Cancer	1.1	1.4	1.5	1.2	-1.2
Ever highly irritable/argumentative for 2 days	1.1	1.3	1.8	-1.3	0.9
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	2.6	1.0	-1.6
Alcohol intake frequency.	1.1	2.7	5.2	0.3	-2.3
Whole body fat-free mass	1.1	6.2	9.7	-3.1	1.6
Average weekly red wine intake	1.1	1.7	2.2	1.1	1.5
Mineral and other dietary supplements	1.1	1.5	2.8	-0.4	1.7
Whole body water mass	1.1	6.4	10.1	-3.2	1.7
Ulcerative Colitis (UC)	1.0	1.8	2.7	-1.7	1.0
Heel T-Score	1.0	7.9	10.6	3.2	-2.3
Fed-up feelings	1.0	1.9	2.8	-1.7	1.0
Multivitamins +/- minerals	1.0	1.3	2.3	-1.5	-0.6
Trunk fat-free mass	1.0	5.8	10.0	-3.2	1.3
Trunk predicted mass	1.0	5.5	9.5	-3.1	1.2
Standing height	1.0	9.9	10.4	-3.2	-3.1
Mood swings	1.0	1.8	3.6	-1.9	0.2
Leg predicted mass (right)	1.0	5.1	8.1	-2.8	1.4
Hearing aid user	1.0	1.1	2.0	-1.4	-0.5
Unable to work because of sickness or disability	1.0	1.2	2.2	-1.5	0.5
Pain experienced in last month	1.0	1.6	1.7	1.3	-1.2
Bipolar Disorder or Schizophrenia	0.9	2.2	4.4	-0.2	2.1
Rheumatoid Arthritis	0.9	1.2	1.7	-1.3	0.8
Lung FVC	0.9	4.5	7.9	-2.8	-1.0
Hearing difficulty/problems: Yes	0.9	1.4	2.7	-1.6	0.3
Number of incorrect matches in round	0.9	1.5	2.8	-0.4	1.7
Past tobacco smoking	0.9	1.7	2.6	-1.6	0.9
Hair/balding pattern: Pattern 2	0.9	1.1	1.7	1.3	-0.7
Noisy workplace	0.9	1.1	1.7	-1.3	0.7
Medication: Cholesterol lowering	0.9	1.4	2.2	-0.8	1.5
Illnesses of mother	0.9	1.1	2.1	-1.4	0.4
Age at first live birth	0.9	1.7	1.7	1.2	-1.3
Emphysema/chronic bronchitis	0.9	1.0	1.4	0.8	-1.2
Number of full sisters	0.9	1.1	2.2	-1.5	-0.1
Leg fat-free mass (right)	0.9	4.8	8.0	-2.8	1.3
Diabetes diagnosed by doctor	0.9	1.5	2.4	-0.8	1.6
Medication for cholesterol	0.9	1.3	2.4	-1.5	-0.5
Tinnitus: Yes, now most or all of the time	0.9	1.0	2.0	0.3	-1.4
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	1.8	0.6	-1.4
Depression (Nagel 2018)	0.8	1.2	2.3	-1.5	0.4
Ever had hysterectomy (womb removed)	0.8	0.9	1.8	-1.3	-0.1
Trunk fat percentage	0.8	3.3	5.9	-0.9	2.4
Alcohol usually taken with meals	0.8	1.3	2.2	0.6	1.5
Arm fat percentage (right)	0.8	3.2	6.5	-0.1	2.5
Qualifications: NVQ or HND or HNC or equivalent	0.8	1.0	1.1	-1.1	0.9
Back pain experienced in last month	0.8	1.1	2.0	-0.4	1.4
Ever taken oral contraceptive pill	0.8	0.9	1.5	-1.2	0.6
Cholesterol lowering medication	0.8	1.2	2.4	0.2	1.6
Age at First Birth	0.7	1.0	2.0	1.4	0.0
Crohns Disease (2012)	0.7	1.1	2.1	-1.4	0.1
Schizophrenia (2014)	0.7	1.6	2.7	-0.7	1.6
Height	0.7	14.0	15.3	-3.6	-3.9
Systolic Blood Pressure	0.7	3.4	6.2	-0.8	2.5
Severe depression (siblings)	0.7	0.8	0.8	-0.9	-0.8
Prospective memory result	0.7	0.9	1.8	-0.2	-1.3
Angina (self-reported)	0.7	0.9	1.6	1.3	0.3
Eye problems/disorders: Cataract	0.7	0.8	1.6	0.1	-1.2
Medication: Aspirin	0.7	1.0	1.9	-0.0	1.4
Risk taking	0.7	1.0	1.8	-0.4	-1.3
Tanning	0.6	6.9	9.1	-3.0	2.2
Sensitivity / hurt feelings	0.6	1.1	1.5	1.2	-0.8
Diabetes (father)	0.6	0.8	1.4	-0.4	1.2
Average weekly fortified wine intake	0.6	0.7	1.2	-0.4	-1.1
High blood pressure	0.6	1.6	3.0	0.5	1.7
Hair/balding pattern: Pattern 3	0.6	0.9	0.9	-0.9	1.0
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	0.8	0.9	-0.7
Headache pain in last month	0.6	1.0	1.7	-1.3	-0.5
Worry too long after embarrassment	0.6	1.0	1.5	0.6	-1.2
Medication: Omeprazole	0.6	0.7	0.9	0.7	-1.0
Mean time to correctly identify matches	0.6	1.1	1.1	1.0	1.1
Comparative height size at age 10	0.6	3.6	4.0	-2.0	-1.8
Medication: Gliclazide	0.6	0.7	1.3	-1.2	0.3
Medication: Blood pressure	0.6	1.2	1.6	1.3	0.9
Medication: Atorvastatin	0.6	0.8	1.6	1.3	0.1
Illnesses of father: High blood pressure	0.6	0.8	1.0	-0.7	1.0
Age started oral contraceptive pill	0.6	0.8	1.4	1.2	-0.4
Alzheimer’s Disease (including proxy)	0.5	0.7	1.4	0.1	1.2
Crohns Disease (2017)	0.5	1.0	2.0	-1.4	0.4
Prostate Cancer	0.5	0.8	1.2	-1.1	0.6
Lupus	0.5	0.8	1.5	-0.2	1.2
Blood White Count	0.5	3.6	4.7	-1.6	2.2
Allergy or Eczema	0.5	1.3	2.4	1.6	0.3
Angina	0.5	0.7	1.0	1.0	0.6
Townsend deprivation index at recruitment	0.5	0.7	1.1	-1.0	0.5
Current tobacco smoking	0.5	0.7	1.2	-1.1	0.5
Taking other prescription medications	0.5	0.8	1.6	0.1	1.2
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	1.6	1.3	-0.8
Had other major operations	0.5	0.6	0.7	-0.8	0.6
Medication: Ramipril	0.5	0.7	1.1	0.5	1.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.4	1.2	0.2
Glaucoma (self-reported)	0.5	0.6	1.2	0.2	1.1
Comparative body size at age 10	0.5	1.3	2.6	0.2	1.6
Number of full brothers	0.5	0.6	0.9	-1.0	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	0.7	0.9	-0.6
Medication: Aspirin	0.5	0.6	1.1	0.3	1.1
Long-standing illness, disability or infirmity	0.5	0.8	1.0	-0.8	1.0
Breast cancer (self-reported)	0.5	0.6	1.1	1.1	-0.2
Medication: Bendroflumethiazide	0.5	0.7	1.3	-0.4	1.2
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.2	1.1	0.1
Intelligence (Savage-Jansen 2018)	0.4	1.1	1.7	1.3	-0.7
Neuroticism (Nagel 2018)	0.4	0.9	1.7	-0.4	-1.3
Schizophrenia (2018)	0.4	0.8	1.3	1.2	0.6
Breast Cancer	0.4	1.1	1.1	1.0	-1.0
Medication for hormone replacement therapy	0.4	0.4	0.8	0.9	-0.1
Supplements: Zinc	0.4	0.5	0.8	0.4	-0.9
Diabetes (mother)	0.4	0.5	0.9	0.3	-0.9
Age when periods started (menarche)	0.4	1.0	1.4	-1.2	0.8
Tinnitus: Yes, but not now, but have in the past	0.4	0.5	0.6	0.8	0.5
Mouth/teeth dental problems	0.4	0.6	0.8	-0.6	-0.9
Hayfever/allergic rhinitis (self-reported)	0.4	0.6	0.7	0.8	0.7
Medication: Lansoprazole	0.4	0.4	0.5	0.6	0.7
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	0.7	-0.7	0.9
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.9	1.0	0.0
Number of children fathered	0.4	0.5	0.8	-0.3	0.9
Medication: Seretide 50 evohaler	0.4	0.5	0.7	-0.8	-0.6
Chest pain or discomfort	0.4	0.5	0.6	0.7	-0.8
Age at last live birth	0.4	0.6	1.2	0.1	-1.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	0.9	-1.0	-0.8
Friendships satisfaction	0.4	0.4	0.5	-0.6	0.7
Smoking status: Current	0.4	0.7	1.0	-1.0	0.7
Vascular/heart problems diagnosed by doctor	0.4	1.2	2.2	-0.5	-1.5
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.7	0.6	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	0.9	-0.9	0.5
Reaction Time	0.3	0.6	0.8	0.9	0.7
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.6	-0.8	0.0
Maternal smoking around birth	0.3	0.4	0.8	-0.9	0.2
High blood pressure (mother)	0.3	0.4	0.6	0.5	-0.8
Impedance of leg (left)	0.3	1.4	2.4	0.7	-1.6
Hearing difficulty/problems with background noise	0.3	0.5	0.6	-0.8	0.7
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.1	0.6	-1.0
Heart attack	0.3	0.3	0.6	0.3	-0.8
Pain all over the body in last month	0.3	0.3	0.4	0.6	0.4
Father’s age at death	0.3	0.5	0.9	0.1	-1.0
Falls in the last year	0.3	0.4	0.8	-0.9	-0.1
Length of working week for main job	0.3	0.3	0.6	-0.7	0.2
Exposure to tobacco smoke at home	0.3	0.4	0.5	-0.5	0.7
Tense / ‘highly strung’	0.3	0.5	0.8	-0.9	0.4
Birth weight of first child	0.3	0.6	1.2	0.1	1.1
Blood clot in the leg (DVT)	0.3	0.4	0.6	-0.8	0.4
Birth weight	0.3	0.7	1.4	0.2	1.2
Eye problems/disorders: None of the above	0.3	0.4	0.7	0.8	0.3
Neck or shoulder pain in last month	0.3	0.5	0.7	-0.5	0.8
Migraine (self-reported)	0.3	0.4	0.7	-0.9	-0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	0.7	0.8	0.3
Hypertension (Self-reported)	0.3	0.7	1.2	0.5	1.1
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.7	-0.4	-0.8
High cholesterol (Self-reported)	0.3	0.5	1.0	-0.2	1.0
Basal cell carcinoma (self-reported)	0.3	0.3	0.4	-0.4	0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.7	0.5	-0.9
Mean Putamen Volume	0.2	0.3	0.6	0.8	0.0
Blood Red Count	0.2	1.6	2.7	1.6	-0.7
Waist Hip Ratio (WHR)	0.2	0.8	1.5	1.2	0.4
Smoking Status	0.2	0.5	0.9	0.9	0.3
Qualifications: CSEs or equivalent	0.2	0.3	0.5	0.2	-0.7
Serious illness, injury or assault to yourself	0.2	0.2	0.4	-0.6	-0.1
Hayfever, allergic rhinitis or eczema	0.2	0.4	0.8	0.9	0.3
Stomach or abdominal pain in last month	0.2	0.2	0.3	-0.5	-0.4
Financial difficulties in last 2 years	0.2	0.3	0.6	-0.8	-0.2
Worrier / anxious feelings	0.2	0.3	0.5	0.7	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.4	0.1	-0.6
Qualifications: College or University degree	0.2	0.6	0.8	0.6	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.3	0.6	-0.4
Pain type(s) experienced in last month: Hip pain	0.2	0.2	0.4	0.3	0.6
Medication: Lisinopril	0.2	0.3	0.4	-0.6	0.5
Myopia	0.2	0.4	0.6	-0.3	-0.8
Heart disease (siblings)	0.2	0.2	0.5	-0.1	-0.7
Worry (Nagel 2018)	0.1	0.3	0.5	0.3	-0.7
Alzheimer’s Disease (in mother)	0.1	0.2	0.3	0.6	-0.2
Body Mass Index (BMI) (2010)	0.1	0.1	0.2	-0.4	0.0
HbA1C	0.1	0.1	0.2	0.2	-0.4
Respiratory disease	0.1	0.2	0.3	-0.3	0.5
Neuroticism	0.1	0.2	0.4	-0.1	-0.6
Chronotype (morning person)	0.1	0.3	0.5	-0.7	-0.4
Impedance of leg (right)	0.1	0.5	1.0	0.3	-1.0
Supplements: Glucosamine	0.1	0.2	0.2	-0.4	-0.4
Diverticular disease/diverticulitis (self-reported)	0.1	0.1	0.2	-0.3	-0.4
Nervous feelings	0.1	0.2	0.4	-0.3	-0.6
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.1	0.1	0.2	-0.4
Qualifications: None of the above	0.1	0.3	0.4	0.5	0.6
Allergy	0.1	0.2	0.4	-0.2	-0.6
Fluid intelligence score	0.1	0.2	0.3	0.6	-0.2
Illnesses of siblings	0.1	0.1	0.2	0.0	-0.4
Neuroticism score	0.1	0.3	0.6	-0.8	-0.1
Breastfed as a baby	0.1	0.2	0.3	-0.6	-0.0
Loud music exposure frequency	0.1	0.1	0.3	-0.5	0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.3	-0.5	0.3
Medication: Amlodipine	0.1	0.2	0.3	0.2	-0.6
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.1	-0.3	-0.3
High blood pressure (siblings)	0.1	0.2	0.3	-0.1	0.6
Shortness of breath walking on level ground	0.1	0.2	0.3	0.6	-0.0
Illnesses of siblings: Diabetes	0.1	0.1	0.3	-0.5	0.0
Number of self-reported non-cancer illnesses	0.1	0.2	0.4	0.7	-0.2
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.4	-0.0
Alcohol drinker status: Never	0.1	0.2	0.2	0.4	0.4
Number of operations (self-reported)	0.1	0.2	0.2	-0.4	-0.5
Irritability	0.1	0.2	0.5	-0.2	0.7
Pack years of smoking	0.1	0.2	0.3	0.1	0.5
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0
HDL Cholesterol	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.0	0.0	0.0
Neuroticism (2016)	0.0	0.0	0.0	0.0	0.0
Primary Biliary Cirrhosis	0.0	0.0	0.1	0.3	0.0
Triglycerides	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0
Hypothyroidism (self reported)	0.0	0.0	0.0	-0.1	0.0
Lung FEV1/FVC ratio	0.0	0.2	0.3	-0.2	0.6
Hair Pigment	0.0	0.6	1.1	1.1	-0.2
Medication: Co-codamol	0.0	0.0	0.0	-0.2	-0.2
Pack years adult smoking proportion	0.0	0.1	0.1	-0.0	0.4
Medication: Levothyroxine sodium	0.0	0.1	0.1	-0.3	0.2
Time employed in main current job	0.0	0.1	0.1	0.3	0.0
Qualifications: A levels/AS levels or equivalent	0.0	0.0	0.1	0.2	-0.1
Asthma	0.0	0.0	0.0	-0.1	0.2
Pulse wave reflection index	0.0	0.0	0.0	0.0	0.0
Wheeze or whistling in the chest in last year	0.0	0.0	0.0	0.1	-0.1
Qualifications: nursing, teaching	0.0	0.0	0.0	-0.1	-0.2
Asthma (self-reported)	0.0	0.1	0.1	-0.2	0.3
Eye problems/disorders: Glaucoma	0.0	0.0	0.0	0.2	-0.2

Hub : Genes

CYP1A1

Models

Trait associations