Hub : Genes

CYP1A1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Brain Lower Grade Glioma 0.0636 0.0333 0.00015 0.058 0.046 0.044 NA 0.053 3.5e-07 5.9e-06 8.6e-06 NA 1.1e-06
2 TCGA Prostate Adenocarcinoma 0.0614 0.0444 0.00680 0.032 0.023 0.033 NA 0.023 2.6e-04 1.7e-03 1.9e-04 NA 1.8e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 3.1 5.0 7.0 -1.7 2.6
Bipolar Disorder or Schizophrenia 0.9 2.2 4.4 -0.2 2.1
Depressed Affect (Nagel 2018) 1.1 2.3 4.6 -2.1 0.1
Depression (Nagel 2018) 0.8 1.2 2.3 -1.5 0.4
Intelligence (Savage-Jansen 2018) 0.4 1.1 1.7 1.3 -0.7
Neuroticism (Nagel 2018) 0.4 0.9 1.7 -0.4 -1.3
Schizophrenia (2018) 0.4 0.8 1.3 1.2 0.6
Schizophrenia vs Biploar Disorder 2.5 3.3 5.8 1.0 -2.4
Worry (Nagel 2018) 0.1 0.3 0.5 0.3 -0.7
Alzheimer’s Disease (in mother) 0.1 0.2 0.3 0.6 -0.2
Alzheimer’s Disease (in father) 3.0 3.3 3.6 -1.7 1.9
Alzheimer’s Disease (including proxy) 0.5 0.7 1.4 0.1 1.2
Crohns Disease (2017) 0.5 1.0 2.0 -1.4 0.4
Irritable Bowel Disease (IBD) 1.1 2.6 4.1 -2.0 1.1
Ulcerative Colitis (UC) 1.0 1.8 2.7 -1.7 1.0
Major Depression (MDD) 2.5 3.0 4.5 -2.1 1.3
Reaction Time 0.3 0.6 0.8 0.9 0.7
Verbal and Numeric Reasoning (VNR) 0.2 0.5 0.7 0.5 -0.9
Breast Cancer 0.4 1.1 1.1 1.0 -1.0
Ovarian Cancer 1.1 1.4 1.5 1.2 -1.2
Prostate Cancer 0.5 0.8 1.2 -1.1 0.6
Age at First Birth 0.7 1.0 2.0 1.4 0.0
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.1 0.1 0.2 -0.4 0.0
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.7 1.1 2.1 -1.4 0.1
Mean Putamen Volume 0.2 0.3 0.6 0.8 0.0
Fasting Glucose 1.3 1.6 2.0 1.4 -1.1
HbA1C 0.1 0.1 0.2 0.2 -0.4
HDL Cholesterol 0.0 0.0 0.0 0.0 0.0
LDL Cholesterol 0.0 0.0 0.0 0.0 0.0
Lupus 0.5 0.8 1.5 -0.2 1.2
Neuroticism (2016) 0.0 0.0 0.0 0.0 0.0
Primary Biliary Cirrhosis 0.0 0.0 0.1 0.3 0.0
Rheumatoid Arthritis 0.9 1.2 1.7 -1.3 0.8
Schizophrenia (2014) 0.7 1.6 2.7 -0.7 1.6
Triglycerides 0.0 0.0 0.0 0.0 0.0
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 2.1 3.0 3.6 -1.9 1.6
Blood Eosinophil Count 1.7 13.3 13.6 3.6 -3.7
Blood Platelet Count 2.8 32.3 50.0 -3.8 7.1
Blood Red Count 0.2 1.6 2.7 1.6 -0.7
Blood White Count 0.5 3.6 4.7 -1.6 2.2
Heel T-Score 1.0 7.9 10.6 3.2 -2.3
BMI 2.3 13.1 24.6 -1.2 5.0
Height 0.7 14.0 15.3 -3.6 -3.9
Waist Hip Ratio (WHR) 0.2 0.8 1.5 1.2 0.4
Systolic Blood Pressure 0.7 3.4 6.2 -0.8 2.5
Smoking Status 0.2 0.5 0.9 0.9 0.3
Allergy or Eczema 0.5 1.3 2.4 1.6 0.3
Cardiovascular Disease 1.3 4.3 7.1 -1.2 2.7
Hypothyroidism (self reported) 0.0 0.0 0.0 -0.1 0.0
Respiratory disease 0.1 0.2 0.3 -0.3 0.5
Type 2 Diabetes (T2D) (2018) 2.3 4.4 7.0 -1.3 2.6
Lung FEV1/FVC ratio 0.0 0.2 0.3 -0.2 0.6
Lung FVC 0.9 4.5 7.9 -2.8 -1.0
Neuroticism 0.1 0.2 0.4 -0.1 -0.6
Chronotype (morning person) 0.1 0.3 0.5 -0.7 -0.4
Hair Pigment 0.0 0.6 1.1 1.1 -0.2
Tanning 0.6 6.9 9.1 -3.0 2.2
Hand grip strength (left) 3.0 7.9 15.7 -4.0 -0.0
Number of treatments/medications taken 3.0 5.4 8.2 -1.6 2.9
Average weekly spirits intake 1.5 1.9 3.7 0.3 1.9
Sensitivity / hurt feelings 0.6 1.1 1.5 1.2 -0.8
Frequency of depressed mood in last 2 weeks 1.5 2.1 3.3 -1.8 0.9
Hearing difficulty/problems: Yes 0.9 1.4 2.7 -1.6 0.3
Relative age of first facial hair 1.2 2.6 4.3 0.9 -2.1
Other serious medical condition/disability diagnosed by doctor 1.7 2.2 4.4 -2.1 0.1
Ever used hormone-replacement therapy (HRT) 2.6 3.3 4.0 2.0 -1.6
Ever had hysterectomy (womb removed) 0.8 0.9 1.8 -1.3 -0.1
Systolic blood pressure, automated reading 2.3 6.7 11.1 -1.5 3.3
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.6 -0.8 0.0
Angina 0.5 0.7 1.0 1.0 0.6
Medication for hormone replacement therapy 0.4 0.4 0.8 0.9 -0.1
Vitamin and mineral supplements 1.9 2.5 4.8 0.5 2.2
Supplements: Zinc 0.4 0.5 0.8 0.4 -0.9
Medication: Co-codamol 0.0 0.0 0.0 -0.2 -0.2
Medication: Metformin 1.3 1.9 3.5 -0.5 1.9
Diabetes (father) 0.6 0.8 1.4 -0.4 1.2
Diabetes (mother) 0.4 0.5 0.9 0.3 -0.9
Severe depression (siblings) 0.7 0.8 0.8 -0.9 -0.8
Pack years adult smoking proportion 0.0 0.1 0.1 -0.0 0.4
Impedance of leg (right) 0.1 0.5 1.0 0.3 -1.0
Leg fat-free mass (left) 1.3 6.7 9.4 -3.1 2.0
Trunk fat percentage 0.8 3.3 5.9 -0.9 2.4
Hand grip strength (right) 1.6 4.4 6.2 -2.5 -1.6
Townsend deprivation index at recruitment 0.5 0.7 1.1 -1.0 0.5
Current tobacco smoking 0.5 0.7 1.2 -1.1 0.5
Average weekly fortified wine intake 0.6 0.7 1.2 -0.4 -1.1
Maternal smoking around birth 0.3 0.4 0.8 -0.9 0.2
Fed-up feelings 1.0 1.9 2.8 -1.7 1.0
Frequency of unenthusiasm / disinterest in last 2 weeks 1.7 2.3 3.5 -1.9 1.0
Relative age voice broke 3.4 5.2 5.5 2.2 -2.4
Taking other prescription medications 0.5 0.8 1.6 0.1 1.2
Age when periods started (menarche) 0.4 1.0 1.4 -1.2 0.8
Bilateral oophorectomy (both ovaries removed) 1.3 1.5 2.7 0.5 -1.6
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 1.6 1.3 -0.8
Tinnitus: Yes, but not now, but have in the past 0.4 0.5 0.6 0.8 0.5
Qualifications: CSEs or equivalent 0.2 0.3 0.5 0.2 -0.7
Serious illness, injury or assault to yourself 0.2 0.2 0.4 -0.6 -0.1
High blood pressure 0.6 1.6 3.0 0.5 1.7
Hayfever, allergic rhinitis or eczema 0.2 0.4 0.8 0.9 0.3
Multivitamins +/- minerals 1.0 1.3 2.3 -1.5 -0.6
Stomach or abdominal pain in last month 0.2 0.2 0.3 -0.5 -0.4
Supplements: Glucosamine 0.1 0.2 0.2 -0.4 -0.4
Diverticular disease/diverticulitis (self-reported) 0.1 0.1 0.2 -0.3 -0.4
Medication: Atenolol 2.7 3.4 4.5 -1.5 2.1
Medication: Levothyroxine sodium 0.0 0.1 0.1 -0.3 0.2
Sitting height 2.7 19.2 37.8 -6.2 0.7
Chronic bronchitis/emphysema (father) 1.5 1.7 2.7 -1.6 0.9
High blood pressure (mother) 0.3 0.4 0.6 0.5 -0.8
Body mass index (BMI) 2.5 10.8 18.9 -1.7 4.3
Impedance of leg (left) 0.3 1.4 2.4 0.7 -1.6
Leg predicted mass (left) 1.2 6.6 9.2 -3.0 2.0
Trunk fat mass 1.2 5.3 7.5 -1.8 2.7
Waist circumference 1.6 5.8 8.8 -1.7 3.0
Number of incorrect matches in round 0.9 1.5 2.8 -0.4 1.7
Past tobacco smoking 0.9 1.7 2.6 -1.6 0.9
Alcohol usually taken with meals 0.8 1.3 2.2 0.6 1.5
Nervous feelings 0.1 0.2 0.4 -0.3 -0.6
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.1 0.1 0.2 -0.4
Hearing difficulty/problems with background noise 0.3 0.5 0.6 -0.8 0.7
Hair/balding pattern: Pattern 2 0.9 1.1 1.7 1.3 -0.7
Had menopause 1.9 2.3 3.2 1.8 -1.2
Had other major operations 0.5 0.6 0.7 -0.8 0.6
Forced vital capacity (FVC) 2.1 8.2 14.9 -3.9 -1.2
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.7 1.1 0.6 -1.0
Ever unenthusiastic/disinterested for a whole week 2.9 3.5 6.7 -2.6 0.6
Qualifications: None of the above 0.1 0.3 0.4 0.5 0.6
Financial difficulties in last 2 years 0.2 0.3 0.6 -0.8 -0.2
Mouth/teeth dental problems 0.4 0.6 0.8 -0.6 -0.9
Heart attack 0.3 0.3 0.6 0.3 -0.8
Allergy 0.1 0.2 0.4 -0.2 -0.6
Pain all over the body in last month 0.3 0.3 0.4 0.6 0.4
Diabetes (self-reported) 1.7 2.6 4.3 -0.9 2.1
Hayfever/allergic rhinitis (self-reported) 0.4 0.6 0.7 0.8 0.7
Medication: Ramipril 0.5 0.7 1.1 0.5 1.0
Medication: Simvastatin 1.7 2.6 2.6 -1.6 1.6
Fluid intelligence score 0.1 0.2 0.3 0.6 -0.2
Illnesses of siblings 0.1 0.1 0.2 0.0 -0.4
Neuroticism score 0.1 0.3 0.6 -0.8 -0.1
Weight 1.7 8.4 9.1 -3.0 2.8
Impedance of arm (right) 3.9 18.2 27.9 2.9 -5.3
Arm fat percentage (right) 0.8 3.2 6.5 -0.1 2.5
Trunk fat-free mass 1.0 5.8 10.0 -3.2 1.3
Hip circumference 1.4 6.2 6.3 -2.5 2.5
Time employed in main current job 0.0 0.1 0.1 0.3 0.0
Alcohol intake versus 10 years previously 4.0 6.0 12.0 -0.1 -3.5
Father’s age at death 0.3 0.5 0.9 0.1 -1.0
Worrier / anxious feelings 0.2 0.3 0.5 0.7 -0.3
Frequency of tiredness / lethargy in last 2 weeks 1.6 2.5 3.0 -1.4 1.7
Falls in the last year 0.3 0.4 0.8 -0.9 -0.1
Hair/balding pattern: Pattern 3 0.6 0.9 0.9 -0.9 1.0
Number of live births 1.6 2.2 4.1 -0.5 -2.0
Forced expiratory volume in 1-second (FEV1) 1.9 6.5 12.5 -3.5 -0.7
Pulse rate 1.9 3.2 5.4 -2.3 1.0
Happiness 2.2 2.7 3.0 -1.7 1.6
Noisy workplace 0.9 1.1 1.7 -1.3 0.7
Qualifications: A levels/AS levels or equivalent 0.0 0.0 0.1 0.2 -0.1
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.6 0.8 0.9 -0.7
Mouth/teeth dental problems: Dentures 1.6 2.8 4.6 -1.0 2.1
Asthma 0.0 0.0 0.0 -0.1 0.2
Medication: Ibuprofen (e.g. Nurofen) 2.0 2.5 3.3 -1.3 1.8
Medication: Cholesterol lowering 0.9 1.4 2.2 -0.8 1.5
Depression (self-reported) 2.4 2.9 5.3 -0.7 2.3
Medication: Lansoprazole 0.4 0.4 0.5 0.6 0.7
Prospective memory result 0.7 0.9 1.8 -0.2 -1.3
Lung cancer (father) 1.5 1.7 2.0 1.4 -1.2
Illnesses of mother 0.9 1.1 2.1 -1.4 0.4
Forced expiratory volume in 1-second (FEV1), Best measure 1.9 6.1 11.8 -3.4 -0.7
Pulse wave Arterial Stiffness index 1.8 2.1 3.6 -0.8 1.9
Impedance of arm (left) 3.2 15.0 22.2 2.8 -4.7
Arm fat mass (right) 1.2 4.9 7.9 -1.4 2.8
Trunk predicted mass 1.0 5.5 9.5 -3.1 1.2
Standing height 1.0 9.9 10.4 -3.2 -3.1
Length of working week for main job 0.3 0.3 0.6 -0.7 0.2
Exposure to tobacco smoke at home 0.3 0.4 0.5 -0.5 0.7
Breastfed as a baby 0.1 0.2 0.3 -0.6 -0.0
Tense / ‘highly strung’ 0.3 0.5 0.8 -0.9 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 2.7 4.1 4.6 -1.9 2.1
Hair/balding pattern: Pattern 4 1.7 4.1 5.2 -2.3 1.7
Birth weight of first child 0.3 0.6 1.2 0.1 1.1
Peak expiratory flow (PEF) 1.7 4.0 7.7 0.6 -2.8
Pulse wave reflection index 0.0 0.0 0.0 0.0 0.0
Ever highly irritable/argumentative for 2 days 1.1 1.3 1.8 -1.3 0.9
Loud music exposure frequency 0.1 0.1 0.3 -0.5 0.1
Qualifications: O levels/GCSEs or equivalent 0.4 0.6 0.7 -0.7 0.9
Mouth/teeth dental problems: Bleeding gums 0.5 0.7 1.4 1.2 0.2
Blood clot in the leg (DVT) 0.3 0.4 0.6 -0.8 0.4
Medication: Paracetamol 2.7 4.5 4.9 -2.2 2.0
Headache pain in last month 0.6 1.0 1.7 -1.3 -0.5
Medication for cholesterol, blood pressure or diabetes 1.1 1.8 2.6 1.0 -1.6
Glaucoma (self-reported) 0.5 0.6 1.2 0.2 1.1
Gout (self-reported) 1.4 1.9 3.7 -0.4 -1.9
Hypothyroidism/myxoedema (self-reported) 0.1 0.2 0.3 -0.5 0.3
Medication: Amlodipine 0.1 0.2 0.3 0.2 -0.6
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.1 -0.3 -0.3
Birth weight 0.3 0.7 1.4 0.2 1.2
Chronic bronchitis/emphysema (mother) 0.4 0.5 0.9 1.0 0.0
High blood pressure (siblings) 0.1 0.2 0.3 -0.1 0.6
Forced vital capacity (FVC), Best measure 1.9 7.1 13.1 -3.6 -1.0
Body fat percentage 1.7 6.7 12.0 -1.2 3.5
Leg fat percentage (right) 4.2 15.4 27.5 -1.8 5.2
Arm fat-free mass (right) 2.0 10.5 13.5 -3.7 2.7
Exposure to tobacco smoke outside home 4.3 5.7 9.1 -1.6 3.0
Comparative body size at age 10 0.5 1.3 2.6 0.2 1.6
Number of full brothers 0.5 0.6 0.9 -1.0 0.6
Worry too long after embarrassment 0.6 1.0 1.5 0.6 -1.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.2 0.4 0.1 -0.6
Wheeze or whistling in the chest in last year 0.0 0.0 0.0 0.1 -0.1
Number of children fathered 0.4 0.5 0.8 -0.3 0.9
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.5 0.7 0.9 -0.6
Age at first live birth 0.9 1.7 1.7 1.2 -1.3
Pulse wave peak to peak time 2.3 2.7 4.6 0.9 -2.2
Health satisfaction 3.6 4.7 4.7 -2.2 2.1
Shortness of breath walking on level ground 0.1 0.2 0.3 0.6 -0.0
Qualifications: College or University degree 0.2 0.6 0.8 0.6 -0.9
Eye problems/disorders: None of the above 0.3 0.4 0.7 0.8 0.3
Mouth/teeth dental problems: Loose teeth 1.4 1.7 2.0 -1.2 1.4
Emphysema/chronic bronchitis 0.9 1.0 1.4 0.8 -1.2
Medication for pain relief, constipation, heartburn 1.2 2.1 2.2 1.4 -1.5
Neck or shoulder pain in last month 0.3 0.5 0.7 -0.5 0.8
Medication: Blood pressure 2.1 3.7 5.8 -1.3 2.4
Angina (self-reported) 0.7 0.9 1.6 1.3 0.3
Migraine (self-reported) 0.3 0.4 0.7 -0.9 -0.2
Medication: Ibuprofen 4.0 4.7 4.9 -2.2 2.1
Medication: Allopurinol 1.4 1.9 3.8 -0.0 -2.0
Medication: Omeprazole 0.6 0.7 0.9 0.7 -1.0
Medication: Seretide 50 evohaler 0.4 0.5 0.7 -0.8 -0.6
Mean time to correctly identify matches 0.6 1.1 1.1 1.0 1.1
Heart disease (mother) 3.2 3.9 4.3 -2.1 1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 3.7 4.4 6.1 1.6 -2.5
Whole body fat mass 1.6 6.7 10.1 -1.8 3.2
Leg fat mass (right) 3.6 14.1 21.3 -2.6 4.6
Arm predicted mass (right) 1.8 9.0 10.6 -3.3 2.7
Pulse rate, automated reading 4.0 12.8 13.5 -3.5 3.7
Alcohol intake frequency. 1.1 2.7 5.2 0.3 -2.3
Comparative height size at age 10 0.6 3.6 4.0 -2.0 -1.8
Number of full sisters 0.9 1.1 2.2 -1.5 -0.1
Suffer from ‘nerves’ 1.6 2.5 3.0 1.7 -1.4
Overall health rating 2.8 6.1 8.3 -2.0 2.9
Chest pain or discomfort 0.4 0.5 0.6 0.7 -0.8
Had major operations 1.3 1.6 1.7 -1.2 1.3
Age at last live birth 0.4 0.6 1.2 0.1 -1.1
Family relationship satisfaction 2.3 2.8 3.5 -1.9 1.4
Leg pain on walking 4.1 5.1 5.1 -2.3 2.3
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 1.1 -1.1 0.9
Commuting to job workplace: Car/motor vehicle 3.3 3.7 5.6 -2.4 1.4
Illness, injury, bereavement, stress in last 2 years 0.3 0.4 0.7 0.8 0.3
Medication: Aspirin 0.5 0.6 1.1 0.3 1.1
Supplements: Vitamin C 3.3 3.9 7.2 0.8 -2.7
Knee pain experienced in last month 4.1 6.4 9.5 -1.8 3.1
Hypertension (Self-reported) 0.3 0.7 1.2 0.5 1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 0.3 0.6 -0.4
Illnesses of father: Heart disease 1.4 1.9 2.0 -1.3 1.4
Illnesses of siblings: Diabetes 0.1 0.1 0.3 -0.5 0.0
Smoking status: Previous 1.3 1.9 3.1 1.8 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 0.9 -1.0 -0.8
Whole body fat-free mass 1.1 6.2 9.7 -3.1 1.6
Leg fat-free mass (right) 0.9 4.8 8.0 -2.8 1.3
Arm fat percentage (left) 1.2 4.8 9.3 -0.5 3.1
Average weekly red wine intake 1.1 1.7 2.2 1.1 1.5
Handedness (chirality/laterality): Left-handed 1.6 1.9 3.8 0.3 1.9
Mood swings 1.0 1.8 3.6 -1.9 0.2
Loneliness, isolation 1.9 2.6 5.1 -2.2 -0.4
Long-standing illness, disability or infirmity 0.5 0.8 1.0 -0.8 1.0
Ever had bowel cancer screening 1.2 1.4 2.3 0.7 -1.5
Diabetes diagnosed by doctor 0.9 1.5 2.4 -0.8 1.6
Ever had stillbirth, spontaneous miscarriage or termination 1.6 1.7 2.7 -1.6 -0.9
Friendships satisfaction 0.4 0.4 0.5 -0.6 0.7
Qualifications: nursing, teaching 0.0 0.0 0.0 -0.1 -0.2
Commuting to job workplace: Walk 1.7 1.8 2.4 1.1 -1.6
Eye problems/disorders: Cataract 0.7 0.8 1.6 0.1 -1.2
Mouth/teeth dental problems: Mouth ulcers 4.3 6.9 7.1 2.7 -2.6
Medication for cholesterol 0.9 1.3 2.4 -1.5 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 2.5 2.9 3.9 -1.4 2.0
Back pain experienced in last month 0.8 1.1 2.0 -0.4 1.4
Mineral and other dietary supplements 1.1 1.5 2.8 -0.4 1.7
Breast cancer (self-reported) 0.5 0.6 1.1 1.1 -0.2
Asthma (self-reported) 0.0 0.1 0.1 -0.2 0.3
Osteoporosis (self-reported) 2.0 2.5 3.7 1.1 -1.9
Osteoarthritis (self-reported) 1.8 2.4 4.7 -0.2 2.2
Medication: Aspirin 0.7 1.0 1.9 -0.0 1.4
Medication: Gliclazide 0.6 0.7 1.3 -1.2 0.3
Illnesses of father: None of the above (group 1) 5.9 7.2 10.7 1.9 -3.3
Smoking status: Current 0.4 0.7 1.0 -1.0 0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.7 5.4 -2.3 0.0
Whole body water mass 1.1 6.4 10.1 -3.2 1.7
Leg predicted mass (right) 1.0 5.1 8.1 -2.8 1.4
Arm fat mass (left) 1.5 6.0 9.9 -1.5 3.1
Number of self-reported non-cancer illnesses 0.1 0.2 0.4 0.7 -0.2
Average weekly champagne plus white wine intake 2.1 2.9 4.1 -1.3 2.0
Miserableness 1.2 2.1 4.1 -2.0 0.4
Guilty feelings 2.1 3.1 4.3 -1.4 -2.1
Wears glasses or contact lenses 1.4 1.6 1.7 -1.2 1.3
Ever taken oral contraceptive pill 0.8 0.9 1.5 -1.2 0.6
Hearing aid user 1.0 1.1 2.0 -1.4 -0.5
Mother’s age at death 3.4 4.2 5.3 2.3 -1.8
Financial situation satisfaction 1.2 1.5 1.7 -1.2 1.3
Tinnitus: Yes, now most or all of the time 0.9 1.0 2.0 0.3 -1.4
Commuting to job workplace: Public transport 0.1 0.1 0.2 0.4 -0.0
Eye problems/disorders: Glaucoma 0.0 0.0 0.0 0.2 -0.2
Medication: Blood pressure 0.6 1.2 1.6 1.3 0.9
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.4 0.3 0.6
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.7 -0.4 -0.8
High cholesterol (Self-reported) 0.3 0.5 1.0 -0.2 1.0
Medication: Bendroflumethiazide 0.5 0.7 1.3 -0.4 1.2
Medication: Paracetamol 3.5 5.3 6.2 -2.5 2.1
Medication: Lisinopril 0.2 0.3 0.4 -0.6 0.5
Medication: Atorvastatin 0.6 0.8 1.6 1.3 0.1
Illnesses of father: High blood pressure 0.6 0.8 1.0 -0.7 1.0
Alcohol drinker status: Never 0.1 0.2 0.2 0.4 0.4
Ever smoked 1.3 2.3 2.7 1.4 -1.6
Basal metabolic rate 1.2 6.9 9.8 -3.1 2.0
Leg fat percentage (left) 3.6 12.9 23.4 -1.5 4.8
Arm fat-free mass (left) 1.3 6.7 9.2 -3.0 2.0
Number of operations (self-reported) 0.1 0.2 0.2 -0.4 -0.5
Average weekly beer plus cider intake 4.1 6.0 11.9 0.2 -3.5
Irritability 0.1 0.2 0.5 -0.2 0.7
Risk taking 0.7 1.0 1.8 -0.4 -1.3
Ever had prostate specific antigen (PSA) test 0.5 0.6 1.2 1.1 0.1
Fractured/broken bones in last 5 years 1.2 1.5 1.6 1.3 -1.2
Age started oral contraceptive pill 0.6 0.8 1.4 1.2 -0.4
Diastolic blood pressure, automated reading 4.1 12.8 16.1 -3.1 4.0
Ever depressed for a whole week 1.7 2.2 3.9 -2.0 0.6
Unable to work because of sickness or disability 1.0 1.2 2.2 -1.5 0.5
Commuting to job workplace: Cycle 3.5 4.3 5.9 2.4 -1.6
Myopia 0.2 0.4 0.6 -0.3 -0.8
Vascular/heart problems diagnosed by doctor 0.4 1.2 2.2 -0.5 -1.5
Cholesterol lowering medication 0.8 1.2 2.4 0.2 1.6
Medication: Omeprazole (e.g. Zanprol) 0.9 1.1 1.8 0.6 -1.4
Pain experienced in last month 1.0 1.6 1.7 1.3 -1.2
Supplements: Calcium 3.6 4.0 7.5 0.7 -2.7
Basal cell carcinoma (self-reported) 0.3 0.3 0.4 -0.4 0.7
Heart attack/myocardial infarction (self-reported) 0.4 0.5 0.7 0.6 -0.8
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 0.9 -0.9 0.5
Heart disease (siblings) 0.2 0.2 0.5 -0.1 -0.7
Alcohol drinker status: Previous 1.8 2.0 3.7 -1.9 0.6
Pack years of smoking 0.1 0.2 0.3 0.1 0.5
Impedance of whole body 1.7 8.4 12.2 2.1 -3.5
Leg fat mass (left) 3.0 11.9 18.6 -2.3 4.3
Arm predicted mass (left) 1.2 5.9 7.8 -2.8 2.0