TWAS hub - TELO2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.3680	0.0440	0.0e+00	0.301	0.248	0.292	0.307	0.294	4.1e-37	7.3e-30	7.3e-36	7.0e-38	3.7e-36
2	GTEx	Adipose Subcutaneous	0.1450	0.0580	1.3e-04	0.072	NA	0.093	NA	0.125	1.5e-06	NA	4.6e-08	NA	2.0e-10
3	GTEx	Artery Tibial	0.2166	0.0707	2.3e-07	0.078	NA	0.176	NA	0.073	1.0e-06	NA	9.3e-14	NA	2.1e-06
4	GTEx	Breast Mammary Tissue	0.1630	0.0740	9.2e-03	0.029	NA	0.038	NA	0.064	1.2e-02	NA	4.7e-03	NA	3.4e-04
5	GTEx	Esophagus Mucosa	0.1720	0.0670	7.2e-03	0.070	NA	0.023	NA	0.054	2.0e-05	NA	1.0e-02	NA	1.6e-04
6	GTEx	Lung	0.1336	0.0569	1.3e-03	0.052	NA	0.083	NA	0.074	7.5e-05	NA	6.7e-07	NA	2.6e-06
7	GTEx	Nerve Tibial	0.3178	0.0731	1.2e-08	0.161	NA	0.156	NA	0.170	1.7e-11	NA	3.8e-11	NA	4.1e-12
8	GTEx	Skin Not Sun Exposed Suprapubic	0.1340	0.0550	7.5e-04	0.163	NA	0.127	NA	0.120	2.9e-09	NA	1.8e-07	NA	4.1e-07
9	GTEx	Skin Sun Exposed Lower leg	0.2900	0.0740	6.8e-07	0.125	NA	0.157	NA	0.185	1.7e-10	NA	5.7e-13	NA	3.1e-15
10	GTEx	Testis	0.4380	0.0980	1.7e-03	0.196	NA	0.134	NA	0.168	4.4e-09	NA	1.5e-06	NA	6.4e-08
11	GTEx	Thyroid	0.4900	0.0620	1.7e-14	0.203	NA	0.330	NA	0.296	1.7e-15	NA	6.6e-26	NA	5.6e-23
12	GTEx	Whole Blood	0.1070	0.0470	9.2e-03	0.000	NA	0.005	NA	-0.001	3.0e-01	NA	9.4e-02	NA	4.3e-01
13	METSIM	Adipose	0.1180	0.0352	3.2e-08	0.088	0.034	0.101	0.078	0.101	4.1e-13	5.6e-06	6.3e-15	1.1e-11	7.6e-15
14	ROSMAP	Brain Pre-frontal Cortex	0.3776	0.0433	0.0e+00	0.212	0.276	0.344	0.333	0.344	1.1e-26	1.3e-35	8.1e-46	4.4e-44	6.9e-46
15	TCGA	Breast Invasive Carcinoma	0.0625	0.0275	4.7e-04	0.003	0.023	0.018	NA	0.005	6.5e-02	1.5e-05	8.7e-05	NA	3.3e-02
16	TCGA	Head and Neck Squamous Cell Carcinoma	0.0572	0.0246	4.2e-04	0.010	0.024	0.030	NA	0.031	2.1e-02	8.4e-04	2.1e-04	NA	1.9e-04
17	TCGA	Brain Lower Grade Glioma	0.0765	0.0336	1.6e-06	0.075	0.061	0.059	NA	0.066	7.4e-09	1.6e-07	2.5e-07	NA	5.1e-08
18	TCGA	Prostate Adenocarcinoma	0.0686	0.0307	9.2e-04	0.041	0.016	0.018	NA	0.040	3.4e-05	7.5e-03	4.8e-03	NA	4.6e-05
19	TCGA	Thyroid Carcinoma	0.0640	0.0250	3.3e-06	0.069	0.067	0.074	NA	0.074	2.9e-07	4.2e-07	1.2e-07	NA	1.1e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13	14	15	16	17	18	19
Age at first live birth	4.7	8.4	18.9	1.2	-3.4	-2.6	-3.1	-3.6	-2.9	-4.3	-2.2	-3.9	-3.3	-2.4	-2.3	-4.0	-1.7	1.6	-2.4	-2.4	-2.5	-3.0
Alzheimer’s Disease (in father)	4.6	5.0	10.4	0.3	2.7	1.6	2.5	2.2	2.7	2.1	1.9	2.6	1.8	1.3	1.3	2.7	2.0	1.9	3.1	2.6	1.8	3.2
Illnesses of father: Heart disease	4.5	6.2	17.5	0.1	-2.3	-3.0	-3.4	-3.1	-2.2	-2.8	-4.2	-2.8	-2.7	-3.5	-2.9	-2.9	-1.4	1.0	0.6	-1.7	-0.3	-1.3
Eye problems/disorders: Glaucoma	4.3	5.1	8.9	1.1	2.6	2.4	2.3	2.4	2.5	2.3	2.0	2.7	2.5	2.0	2.9	3.0	2.6	-0.1	1.9	2.5	0.5	2.0
Pulse wave peak to peak time	3.8	4.5	10.5	-1.1	-2.6	-3.2	-2.7	-2.7	-2.0	-2.3	-1.9	-2.5	-1.7	-2.6	-1.6	-2.1	-2.0	-0.4	-0.9	-2.2	0.6	-2.5
Medication: Allopurinol	3.6	4.8	12.6	-0.9	-2.2	-0.1	-2.9	-2.7	-2.5	-2.9	-2.0	-2.9	-3.1	-2.7	-3.5	-1.7	-2.2	0.4	0.9	-1.1	1.7	-0.9
Osteoarthritis (self-reported)	3.4	4.4	8.6	1.0	-2.5	-1.3	-1.7	-2.1	-2.3	-2.2	-2.0	-2.3	-2.2	-2.6	-1.9	-2.7	-1.1	-2.1	-1.9	-2.4	-0.9	-2.9
Pulse wave Arterial Stiffness index	3.3	3.9	9.9	1.1	2.5	3.1	2.5	2.4	1.9	2.1	1.8	2.3	1.6	2.4	1.5	1.8	1.8	0.5	0.8	2.1	-0.7	2.3
High blood pressure (siblings)	3.3	4.7	8.3	-0.1	-2.3	-2.0	-2.5	-2.5	-1.5	-2.9	-2.6	-2.6	-2.8	-2.7	-2.8	-2.9	-1.9	1.2	0.6	-2.0	0.7	-1.7
Ever taken oral contraceptive pill	3.3	3.6	6.4	1.0	2.5	2.4	2.4	2.1	2.4	1.8	2.2	2.3	1.9	2.0	1.3	2.0	1.7	-0.3	1.2	2.4	-0.0	1.7
Impedance of arm (right)	2.9	13.6	32.8	0.9	3.6	3.5	5.7	3.9	4.5	4.5	5.0	4.4	3.9	5.0	3.4	4.1	2.8	-3.3	-1.3	2.5	-1.5	1.8
Age at First Birth	2.7	4.0	9.3	-2.3	-2.4	-0.9	-2.2	-2.5	-2.2	-2.0	-1.8	-2.5	-2.4	-1.2	-1.9	-1.7	-3.0	2.1	1.3	-1.3	1.3	-1.0
Father’s age at death	2.6	3.4	6.8	1.0	2.1	0.3	2.1	2.6	1.6	2.1	1.9	2.5	1.8	1.4	1.8	2.6	2.1	0.3	1.2	2.1	1.0	2.3
Impedance of arm (left)	2.6	12.2	27.7	1.4	3.6	3.5	5.3	3.7	4.0	4.0	4.8	4.0	3.7	4.8	3.1	3.9	2.9	-2.4	-1.3	2.4	-1.8	1.7
Glaucoma (self-reported)	2.6	3.1	6.4	1.8	2.1	1.5	1.7	2.0	2.2	1.6	1.3	2.1	1.9	0.9	2.2	2.2	2.5	-0.4	1.6	1.6	1.0	1.0
Happiness	2.5	3.0	9.9	-2.2	-1.9	-0.7	-2.1	-2.3	-1.8	-1.4	-1.5	-2.1	-2.1	-0.2	-1.2	-1.5	-3.1	1.3	1.0	-1.3	1.3	-1.4
Age at last live birth	2.5	3.6	9.4	0.4	-2.3	-1.9	-1.5	-1.9	-1.4	-2.8	-0.9	-2.1	-1.8	-1.0	-0.9	-2.7	-1.1	-0.3	-2.5	-1.7	-3.1	-2.6
Eye problems/disorders: Cataract	2.5	2.9	7.6	-1.0	-2.1	-0.6	-2.0	-2.4	-1.6	-2.0	-1.8	-2.1	-2.8	-2.0	-1.7	-1.9	-2.2	1.0	0.3	-0.9	0.0	-1.0
Heart disease (siblings)	2.5	3.0	7.4	0.5	-1.6	-2.2	-1.5	-2.5	-1.7	-2.3	-2.7	-2.1	-2.2	-2.7	-1.4	-2.2	-0.9	0.1	0.3	-1.0	-0.3	-0.8
Ever depressed for a whole week	2.4	3.0	8.0	-1.2	-1.8	-0.7	-2.3	-2.0	-1.4	-1.9	-1.7	-2.0	-2.5	-2.8	-2.0	-1.7	-2.0	0.9	0.6	-1.1	0.9	-1.3
Arm fat-free mass (right)	2.3	11.7	21.1	-0.5	-3.8	-4.1	-4.3	-4.0	-3.9	-4.1	-3.9	-4.1	-2.5	-4.6	-0.7	-4.6	-2.6	1.1	-2.4	-3.6	-2.3	-3.5
Arm predicted mass (right)	2.3	11.9	23.5	-0.4	-3.8	-4.1	-4.5	-4.0	-4.0	-4.2	-4.1	-4.2	-2.7	-4.8	-0.8	-4.5	-2.5	1.4	-2.3	-3.3	-2.0	-3.1
LDL Cholesterol	2.2	3.5	8.5	1.5	2.4	0.4	1.4	2.0	1.5	2.0	1.4	2.2	1.3	1.3	1.9	2.5	2.1	1.5	1.7	2.6	0.7	2.9
Hypothyroidism (self reported)	2.2	5.1	12.2	-1.0	-2.2	-1.7	-3.1	-2.5	-3.5	-2.2	-3.0	-2.7	-2.3	-2.0	-1.2	-2.9	-2.2	1.3	-0.1	-2.7	-0.4	-2.6
Hearing difficulty/problems: Yes	2.2	3.4	7.2	-1.7	-1.5	0.9	-2.5	-2.0	-2.7	-1.9	-1.4	-1.9	-2.3	-2.4	-1.8	-1.0	-2.1	1.7	1.8	-0.4	2.3	0.2
Tinnitus: Yes, but not now, but have in the past	2.2	2.3	4.9	-1.5	-1.9	0.2	-1.5	-1.6	-2.0	-1.9	-0.9	-1.9	-1.6	-1.2	-1.5	-1.5	-2.2	-0.2	0.4	-1.6	0.5	-2.2
Serious illness, injury or assault to yourself	2.2	2.7	6.8	1.1	1.7	1.4	1.9	1.6	2.1	2.1	1.3	1.8	1.8	1.6	2.6	1.7	1.8	-0.7	-1.5	1.5	0.4	1.4
Hypothyroidism/myxoedema (self-reported)	2.2	4.2	12.9	-1.3	-2.2	-1.3	-2.8	-2.2	-3.6	-2.0	-2.5	-2.3	-2.1	-1.9	-1.1	-2.4	-2.0	1.2	0.1	-2.3	0.1	-2.1
Heart disease (mother)	2.2	2.7	8.7	1.1	-1.6	-1.4	-1.5	-2.1	-1.8	-2.2	-1.3	-2.0	-1.8	-2.9	-1.7	-2.0	-0.5	-1.2	-0.9	-1.3	-0.1	-1.4
Supplements: Calcium	2.2	2.4	5.6	0.8	1.9	2.0	1.2	1.7	1.2	1.6	1.7	1.6	1.0	1.3	0.0	2.3	1.5	0.7	1.3	2.0	1.1	2.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.1	2.9	6.9	-1.6	-2.0	-0.1	-2.0	-2.3	-1.6	-1.4	-2.1	-2.3	-2.6	-1.2	-1.6	-1.8	-2.6	0.6	-0.2	-1.2	-0.1	-0.9
Number of self-reported non-cancer illnesses	2.1	3.7	10.3	-1.6	-2.4	-1.9	-2.1	-1.4	-2.0	-1.9	-1.5	-1.9	-1.6	-1.8	-1.7	-2.1	-2.1	-0.8	-0.6	-3.2	0.4	-3.1
Deep venous thrombosis (DVT) (self-reported)	2.1	2.6	6.7	1.8	-1.2	-2.6	-1.5	-1.6	-1.7	-2.2	-2.5	-1.7	-1.4	-2.5	-1.2	-2.2	0.5	0.3	-0.9	-0.9	-0.3	-0.8
Noisy workplace	2.0	2.4	6.5	-1.7	-1.2	0.2	-1.8	-1.5	-2.2	-1.1	-1.8	-1.5	-2.5	-1.4	-2.5	-1.0	-2.2	1.9	0.3	-0.3	0.4	0.2
Blood clot in the leg (DVT)	2.0	2.6	6.3	1.6	-1.2	-2.5	-1.6	-1.6	-1.8	-2.2	-2.4	-1.7	-1.2	-2.4	-0.9	-2.2	0.4	0.1	-1.1	-1.0	-0.2	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	2.0	2.4	6.4	0.0	1.5	1.6	1.2	1.2	1.3	1.1	1.6	1.3	0.4	0.9	1.5	2.1	0.6	1.4	1.8	2.5	2.4	2.3
Guilty feelings	2.0	3.1	8.5	-2.1	-1.9	-0.3	-2.0	-1.7	-1.9	-1.1	-2.2	-2.0	-1.8	-1.4	-1.7	-1.5	-2.9	0.2	1.5	-2.0	0.6	-2.0
Medication: Lisinopril	2.0	2.5	4.8	-0.6	-2.2	-1.9	-1.7	-1.9	-1.5	-1.6	-1.3	-1.9	-1.7	-1.8	-1.1	-1.9	-1.1	0.4	-1.8	-1.9	-1.0	-1.6
Ever smoked	2.0	3.6	7.4	-1.4	-2.5	0.8	-2.5	-2.1	-2.0	-2.7	-1.2	-2.5	-1.9	-1.8	-1.8	-2.6	-2.1	0.2	-0.2	-2.3	0.1	-1.8
Impedance of whole body	2.0	10.0	25.9	1.8	3.4	2.1	5.1	3.5	3.8	3.6	3.4	3.8	3.8	3.9	3.0	3.5	3.0	-3.0	-0.5	2.6	-0.5	2.1
Rheumatoid Arthritis	1.9	2.6	5.8	0.0	-1.8	-0.4	-2.2	-1.9	-2.2	-2.2	-1.5	-2.3	-1.4	-2.4	-1.6	-2.3	-1.1	1.0	0.5	0.0	0.2	-1.2
Sensitivity / hurt feelings	1.9	3.2	7.6	1.1	2.0	0.9	1.3	1.9	1.4	2.4	0.8	2.1	1.8	1.0	2.7	2.8	1.9	0.2	1.6	2.3	1.4	2.1
Diabetes (father)	1.9	2.3	7.2	0.4	1.2	0.3	1.8	1.8	2.7	2.2	1.8	1.7	1.9	0.9	1.6	2.1	1.5	-0.8	-0.3	0.1	-1.7	0.6
Trunk fat-free mass	1.9	10.8	21.1	-0.1	-3.6	-4.0	-3.7	-3.7	-3.2	-3.8	-3.3	-3.8	-2.3	-4.4	-0.4	-4.6	-2.0	0.5	-3.2	-3.8	-3.1	-3.8
Trunk predicted mass	1.9	10.9	21.2	-0.1	-3.6	-4.0	-3.8	-3.7	-3.2	-3.8	-3.3	-3.9	-2.3	-4.4	-0.5	-4.6	-2.1	0.6	-3.0	-3.8	-3.0	-3.8
Arm fat-free mass (left)	1.9	9.5	19.3	-0.1	-3.4	-3.9	-3.7	-3.5	-3.4	-3.8	-3.6	-3.6	-2.1	-4.4	-0.4	-4.2	-1.9	0.4	-2.5	-3.3	-2.2	-3.1
Whole body fat-free mass	1.8	10.2	18.7	-0.5	-3.5	-3.5	-3.9	-3.7	-3.4	-3.7	-3.1	-3.8	-2.3	-4.1	-0.5	-4.3	-2.3	0.8	-3.0	-3.6	-2.9	-3.6
Whole body water mass	1.8	10.1	18.6	-0.5	-3.5	-3.4	-3.8	-3.7	-3.4	-3.6	-3.0	-3.7	-2.3	-4.1	-0.4	-4.3	-2.3	0.8	-3.0	-3.5	-3.0	-3.6
Leg predicted mass (right)	1.8	9.4	15.5	-1.3	-3.5	-2.4	-3.9	-3.7	-3.6	-3.4	-2.4	-3.6	-2.5	-3.4	-0.7	-3.9	-2.9	1.1	-3.0	-3.5	-3.0	-3.7
Intelligence (Savage-Jansen 2018)	1.7	5.2	11.0	-2.3	-2.7	-2.5	-2.9	-2.6	-2.1	-2.7	-1.3	-2.5	-2.6	-2.0	-1.9	-2.6	-3.3	1.1	-1.2	0.0	-1.3	-3.0
Frequency of tenseness / restlessness in last 2 weeks	1.7	2.6	6.5	-1.6	-2.0	-1.1	-1.7	-1.8	-1.4	-0.9	-1.4	-1.8	-1.6	-0.8	-0.5	-1.7	-2.5	0.3	-1.4	-2.2	-1.4	-2.4
Qualifications: None of the above	1.7	3.5	15.9	0.7	1.9	1.6	1.3	0.9	0.9	1.4	0.0	1.3	0.7	-0.2	-0.1	2.3	1.2	-0.1	3.1	3.0	4.0	3.3
Gout (self-reported)	1.7	2.3	6.4	-0.9	-1.4	-1.0	-2.0	-1.5	-1.4	-2.0	-1.5	-1.8	-2.0	-1.8	-2.5	-1.4	-1.7	-0.2	0.0	-1.1	1.4	-1.0
Birth weight	1.7	3.7	9.6	0.4	1.2	1.7	2.2	2.6	1.9	2.3	2.8	2.0	2.7	1.2	2.4	1.2	1.5	-3.1	-1.9	-0.6	-1.5	-0.7
Leg fat-free mass (right)	1.7	9.2	15.4	-1.3	-3.4	-2.4	-3.8	-3.7	-3.6	-3.4	-2.4	-3.6	-2.4	-3.4	-0.7	-3.9	-2.8	1.0	-3.1	-3.5	-3.0	-3.7
Arm predicted mass (left)	1.7	8.7	18.1	-0.2	-3.2	-3.9	-3.5	-3.3	-3.3	-3.5	-3.3	-3.4	-1.9	-4.3	-0.2	-4.0	-1.8	0.1	-2.6	-3.2	-2.0	-3.1
Severe depression (siblings)	1.6	1.8	3.3	1.1	1.5	1.4	1.4	1.2	1.0	1.3	1.8	1.3	1.5	0.1	1.4	1.2	1.6	-1.7	-1.6	0.6	-1.5	0.3
Medication: Ventolin 100micrograms inhaler	1.6	2.1	5.8	0.4	1.5	0.6	2.0	1.9	1.6	1.5	2.4	1.8	1.9	1.6	1.8	1.3	1.2	0.8	0.3	0.7	-0.5	0.8
Knee pain experienced in last month	1.6	2.4	9.9	1.6	-1.0	-0.9	-1.2	-0.6	-1.3	-1.3	-0.3	-0.9	-0.2	-1.6	-0.4	-1.6	0.2	-1.2	-3.1	-2.2	-2.7	-2.6
Pain type(s) experienced in last month: Hip pain	1.6	2.0	4.3	0.2	-1.8	-0.8	-1.1	-1.8	-1.4	-1.8	-1.3	-1.8	-1.6	-2.1	-1.6	-1.6	-0.7	-0.5	-1.6	-1.4	-1.2	-1.0
Impedance of leg (right)	1.5	7.3	19.9	2.8	2.9	0.4	4.5	3.0	3.1	2.8	1.6	3.1	3.3	2.2	2.7	2.7	3.5	-2.9	0.5	2.5	0.5	2.5
Maternal smoking around birth	1.5	2.1	5.2	0.3	1.5	0.4	1.5	2.3	1.7	1.7	1.5	1.9	2.3	1.8	1.9	1.3	1.4	-1.0	-1.1	0.2	-1.0	0.2
Heart attack	1.5	1.9	4.7	-0.9	-1.5	-1.0	-2.0	-1.9	-1.7	-1.1	-2.2	-1.7	-2.0	-1.0	-1.8	-1.0	-1.4	1.2	-0.2	-0.9	-0.1	-0.3
Number of full brothers	1.5	1.9	8.5	2.9	1.6	-0.7	1.1	1.3	1.1	0.5	0.2	1.3	1.8	-0.8	1.1	0.5	2.9	-0.5	-1.0	0.5	-1.5	0.8
Emphysema/chronic bronchitis	1.5	1.7	5.0	-1.0	-1.2	-1.1	-1.6	-1.1	-1.4	-1.2	-1.5	-1.3	-1.0	-2.1	-2.2	-1.1	-1.5	-0.3	-1.1	-1.5	0.4	-0.9
Qualifications: nursing, teaching	1.5	2.4	5.6	-0.8	-1.8	-1.6	-2.4	-1.7	-1.6	-1.8	-1.9	-1.9	-1.9	-1.1	-0.3	-1.7	-1.8	1.8	0.1	-1.0	-0.5	-1.3
Basal metabolic rate	1.5	8.4	15.4	-0.3	-3.1	-3.2	-3.3	-3.2	-3.1	-3.3	-2.6	-3.2	-1.8	-3.7	0.0	-3.9	-1.9	0.4	-3.3	-3.4	-3.2	-3.4
Heart attack/myocardial infarction (self-reported)	1.5	1.9	4.7	-1.0	-1.5	-0.9	-2.0	-1.8	-1.7	-1.1	-2.2	-1.7	-2.0	-1.0	-1.8	-1.0	-1.4	1.2	-0.3	-0.9	-0.2	-0.2
Lupus	1.4	2.1	5.2	-1.4	-1.8	-0.4	-0.8	-2.0	-0.2	-1.5	-0.3	-1.9	-1.8	-0.7	-2.2	-1.6	-2.3	-0.5	-0.7	-1.6	0.0	-2.0
Type 2 Diabetes (T2D) (2012)	1.4	1.6	3.7	0.1	1.7	1.2	1.9	1.0	0.0	1.5	1.1	1.4	1.9	1.7	1.6	1.5	0.7	-1.2	0.5	0.0	0.9	1.0
Average weekly spirits intake	1.4	1.8	4.9	-1.9	-1.5	-0.8	-1.4	-1.3	-2.0	-1.0	-1.5	-1.5	-1.2	-1.2	0.1	-1.3	-2.2	0.4	-0.8	-1.0	-0.3	-1.6
Medication: Levothyroxine sodium	1.4	2.4	9.9	-1.2	-1.5	-0.9	-2.1	-1.7	-3.1	-1.3	-1.9	-1.6	-1.6	-1.6	-1.0	-1.5	-1.7	0.7	0.6	-1.6	0.5	-1.5
Alcohol intake versus 10 years previously	1.4	2.2	7.5	2.7	1.5	-0.8	1.9	1.3	1.8	0.7	0.6	1.3	2.3	-0.2	1.8	0.8	2.7	-1.2	-0.7	0.9	0.3	0.5
Falls in the last year	1.4	1.9	8.4	0.4	-1.1	-0.7	-0.3	-0.6	-0.9	-0.8	0.0	-0.7	0.6	-1.4	0.3	-1.1	-0.2	-2.5	-2.9	-2.2	-1.6	-2.4
Schizophrenia vs Biploar Disorder	1.3	1.7	5.2	0.5	-1.4	-2.2	-1.9	-1.5	0.0	-0.9	-1.7	-1.4	-1.0	-2.3	0.0	-1.2	-0.6	-1.0	0.5	0.0	1.6	-1.4
Blood Platelet Count	1.3	14.6	34.6	2.0	4.1	2.9	5.9	4.3	4.7	3.3	4.5	4.5	5.5	4.9	4.5	3.3	4.0	-2.0	-0.7	2.9	-1.0	2.4
Qualifications: CSEs or equivalent	1.3	1.8	3.7	-0.1	1.3	1.2	1.8	1.0	0.8	1.9	1.3	1.3	0.8	1.1	1.4	1.8	1.0	0.2	1.7	1.8	0.8	1.8
Chronic bronchitis/emphysema (father)	1.3	1.6	5.8	0.8	-0.8	-1.5	-2.0	-1.0	-2.0	-1.5	-1.9	-1.3	-1.0	-2.4	-1.1	-1.1	-0.3	0.0	-0.4	-0.6	-0.2	-0.5
Leg predicted mass (left)	1.3	7.0	12.0	-0.6	-2.8	-2.1	-3.3	-3.2	-3.2	-3.0	-2.0	-3.1	-2.0	-3.2	-0.4	-3.5	-2.0	1.0	-2.7	-3.0	-2.8	-3.1
Chronic bronchitis/emphysema (mother)	1.3	1.5	2.9	-0.0	1.5	1.5	0.9	1.6	1.4	1.6	0.8	1.4	1.1	1.1	0.7	1.7	0.7	0.1	1.4	1.1	1.3	1.4
Commuting to job workplace: Public transport	1.3	1.6	4.0	-1.4	-1.9	-0.5	-1.0	-1.7	-1.2	-1.2	-0.8	-1.4	-1.5	-1.0	-0.7	-1.3	-2.0	0.3	-0.9	-1.5	-0.4	-1.4
Pack years of smoking	1.3	1.9	6.0	-0.7	1.6	1.5	1.5	1.7	1.0	2.4	1.2	1.8	1.5	1.3	1.2	1.9	0.7	0.2	0.1	1.1	-0.5	1.6
Alzheimer’s Disease (including proxy)	1.2	1.8	7.7	1.0	1.5	0.5	0.9	1.1	1.3	0.8	0.9	1.2	0.8	0.3	0.2	1.4	1.5	2.1	2.8	1.3	1.6	1.7
Verbal and Numeric Reasoning (VNR)	1.2	2.9	6.7	-1.5	-1.9	-1.7	-2.6	-1.7	-2.4	-1.7	-1.6	-1.8	-1.8	-1.9	-0.9	-1.7	-2.0	0.8	-0.4	-1.8	-0.4	-1.7
Prostate Cancer	1.2	1.7	4.8	-0.2	1.0	2.2	1.2	1.6	1.0	1.8	1.6	1.4	1.4	1.2	1.4	1.2	0.7	-1.4	-1.2	0.3	-1.6	0.3
Medication for hormone replacement therapy	1.2	1.3	4.0	0.9	-0.9	-1.4	-1.4	-1.3	-0.8	-1.2	-2.0	-1.3	-1.2	-2.0	-1.4	-1.2	-0.2	-0.1	-0.6	-0.6	0.4	-0.7
Medication: Co-codamol	1.2	1.4	3.8	0.0	1.4	0.8	1.4	1.2	0.5	1.4	1.9	1.5	1.2	0.5	1.0	1.5	0.5	-1.9	-1.4	0.8	-1.2	-0.3
Pack years adult smoking proportion	1.2	1.9	5.5	-0.9	1.6	1.4	1.5	1.7	1.0	2.3	1.3	1.8	1.3	1.3	1.0	1.9	0.6	0.6	0.0	1.2	-0.9	1.6
Leg fat-free mass (left)	1.2	6.3	11.0	-0.6	-2.7	-2.1	-3.1	-3.0	-3.0	-2.8	-1.8	-2.9	-1.8	-3.0	-0.2	-3.3	-1.9	0.9	-2.7	-2.9	-2.8	-3.0
Medication: Ibuprofen	1.2	1.5	7.9	0.6	-1.3	-1.3	-0.7	-0.9	-0.2	-1.1	-0.8	-1.1	-0.2	-0.9	1.3	-1.3	-0.3	0.7	-1.6	-1.6	-2.8	-1.5
Had major operations	1.2	1.4	3.4	0.4	1.0	-0.9	1.4	1.8	0.7	1.1	1.1	1.5	1.8	1.1	1.3	1.0	1.4	-1.4	-1.1	-0.2	-1.3	-0.1
Miserableness	1.2	2.0	8.2	1.4	1.3	0.8	1.4	1.3	1.9	2.0	1.4	1.3	1.4	1.0	2.9	1.8	1.5	-0.3	-0.3	0.7	-1.1	0.6
Angina	1.1	1.5	3.0	-0.9	-1.6	-0.8	-1.3	-1.2	-1.4	-1.0	-1.5	-1.4	-1.1	-1.1	-1.5	-1.6	-1.3	-0.3	-1.0	-1.7	-0.6	-1.1
Pulse rate	1.1	1.8	6.9	-0.6	1.4	0.8	2.6	1.3	1.9	1.5	1.1	1.3	0.9	2.6	0.5	1.0	0.3	-0.3	0.1	1.2	-1.4	1.1
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	4.6	-0.4	-1.5	-1.2	-1.0	-0.9	-0.6	-1.0	-1.3	-1.1	-0.4	-0.9	1.0	-1.3	-0.8	0.9	-1.6	-1.5	-2.1	-1.5
Lung cancer (father)	1.1	1.3	3.5	-0.7	-1.1	-1.9	-1.6	-1.2	-1.1	-1.0	-1.6	-1.4	-0.6	-1.0	-1.3	-1.3	-1.3	-0.7	-0.3	-1.2	0.7	-1.0
Shortness of breath walking on level ground	1.1	1.3	2.9	-1.3	-1.1	-1.0	-0.5	-1.0	-0.8	-0.1	-0.9	-1.2	-1.1	-0.6	-1.2	-1.2	-1.7	-0.7	-1.5	-1.4	-1.3	-1.4
Migraine (self-reported)	1.1	1.3	3.3	1.6	1.1	-0.3	1.7	0.9	1.2	1.7	0.5	1.2	0.7	1.4	0.7	1.4	1.8	-0.2	0.5	1.2	-0.7	1.2
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	4.6	-0.4	1.0	0.8	1.0	1.5	0.6	0.9	1.3	1.5	1.3	0.8	1.8	1.0	0.3	-2.1	-0.2	0.8	0.6	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.6	1.5	1.1	0.2	1.1	1.2	0.2	1.0	1.2	1.2	1.9	-0.2	1.9	0.7	1.8	-1.2	-1.4	0.2	-0.5	-0.2
Financial situation satisfaction	1.1	1.3	3.6	-1.9	-1.0	-0.2	-1.2	-0.8	-1.7	-0.5	-1.2	-1.2	-1.1	-0.6	-0.9	-0.8	-1.9	1.9	0.6	-1.1	0.1	-0.5
Depression (Nagel 2018)	1.0	1.5	4.7	-1.5	-1.3	0.5	-1.6	-1.7	-1.1	-0.7	-1.5	-1.6	-1.7	-0.9	-0.1	-1.2	-2.2	0.9	0.2	0.0	-0.4	-1.1
Heel T-Score	1.0	7.9	16.1	2.3	-2.5	-1.4	-3.7	-3.4	-3.4	-2.8	-2.8	-3.2	-3.7	-3.0	-4.0	-2.2	-0.6	1.1	-3.7	-1.7	-3.1	-1.7
Smoking Status	1.0	2.4	4.2	-1.5	-2.0	0.3	-1.9	-1.6	-2.0	-1.5	-1.5	-1.9	-1.4	-1.7	-1.0	-1.8	-1.9	-0.3	-1.2	-2.0	-0.3	-1.5
Type 2 Diabetes (T2D) (2018)	1.0	1.8	6.4	0.9	1.1	0.4	2.2	1.1	1.2	1.4	1.6	1.3	1.3	1.2	1.8	0.8	1.2	-1.0	-1.5	0.4	-2.5	-0.2
Lung FEV1/FVC ratio	1.0	5.1	15.0	0.8	-2.6	-3.1	-0.8	-1.7	-0.1	-2.3	-1.7	-2.3	-1.3	-2.0	-0.7	-3.1	-0.9	-1.8	-2.9	-3.4	-3.0	-3.9
Past tobacco smoking	1.0	1.9	4.3	0.2	1.7	-1.0	2.0	1.6	1.7	2.1	1.2	1.8	1.3	1.7	1.2	1.9	0.9	0.1	0.5	1.3	0.0	0.6
Alcohol usually taken with meals	1.0	1.6	4.7	0.8	1.1	1.4	1.2	1.3	1.8	1.2	1.8	1.3	1.1	0.9	2.2	1.4	1.4	-0.2	-0.6	1.2	0.3	1.1
Peak expiratory flow (PEF)	1.0	2.3	5.0	1.1	-1.3	-2.1	-0.9	-1.8	-1.4	-1.8	-1.4	-1.7	-0.7	-2.1	-0.3	-2.2	-0.3	-1.1	-1.9	-1.5	-1.8	-1.8
Pulse wave reflection index	1.0	1.3	4.5	0.8	1.3	2.0	0.4	1.1	0.2	0.9	-0.0	1.2	0.5	0.2	1.1	1.0	1.1	1.3	1.2	1.6	0.9	2.1
Loud music exposure frequency	1.0	1.1	3.1	-1.7	-0.2	0.1	-1.5	-0.9	-1.0	0.1	-1.0	-0.6	-0.8	-0.6	-0.2	-0.1	-1.8	1.2	1.6	0.5	1.6	0.6
Alcohol intake frequency.	1.0	2.4	6.9	0.5	1.6	1.0	2.6	1.6	1.8	2.3	0.8	1.9	1.8	1.1	1.8	1.9	1.6	-1.7	-0.4	1.3	0.3	1.3
Average weekly red wine intake	1.0	1.5	2.8	1.3	-1.4	-0.6	-1.3	-1.2	-1.1	-1.6	-1.2	-1.5	-1.2	-1.7	-0.6	-1.5	-0.1	-0.7	-1.4	-1.2	-0.7	-1.2
Friendships satisfaction	1.0	1.2	2.3	0.1	-0.9	-1.3	-1.4	-1.5	-1.2	-1.4	-0.7	-1.3	-1.5	-1.1	-1.3	-1.2	-0.9	1.2	0.1	-0.8	-0.3	-0.8
Back pain experienced in last month	1.0	1.4	6.1	1.7	-0.7	-0.5	-0.5	-0.7	-1.0	-1.2	-0.4	-0.6	0.3	-1.6	-0.4	-0.7	1.0	-2.2	-2.5	-1.2	-1.2	-1.2
Wears glasses or contact lenses	1.0	1.1	2.6	1.0	1.0	0.9	1.2	1.1	1.6	0.9	1.4	1.3	0.8	1.2	1.1	1.2	1.3	-0.3	-0.2	1.2	-0.6	0.8
Alcohol drinker status: Previous	1.0	1.1	11.6	-0.2	-0.0	-1.4	0.7	0.5	0.2	0.7	0.1	0.6	1.1	0.4	1.6	0.5	0.2	-3.4	-1.4	0.0	-0.4	-0.4
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.0	-0.2	-1.3	-0.6	-1.3	-0.8	-0.8	-1.4	-0.6	-1.2	-0.9	-1.5	-0.4	-1.3	-0.8	0.2	-1.7	-1.6	-0.9	-1.3
Impedance of leg (left)	0.9	4.6	14.7	1.8	1.9	-0.2	3.8	2.2	2.5	2.1	0.7	2.3	2.8	2.0	2.5	1.9	2.4	-3.2	-0.4	1.7	0.1	1.6
Mouth/teeth dental problems	0.9	1.4	3.8	0.8	1.3	1.4	1.9	0.8	1.4	1.1	1.3	1.1	1.4	1.3	1.7	0.8	1.3	-0.6	-0.7	1.0	-0.9	0.5
Illnesses of siblings	0.9	1.3	4.8	-0.7	1.0	2.2	0.8	1.0	0.4	1.3	1.8	1.2	1.3	1.6	1.1	1.5	0.4	0.7	0.1	1.0	-0.3	1.0
Weight	0.9	4.2	13.4	0.1	-2.1	-2.2	-1.6	-1.8	-2.1	-2.1	-1.3	-1.8	-0.4	-2.4	0.6	-2.6	-0.6	-0.7	-3.7	-2.6	-3.2	-2.6
Standing height	0.9	8.7	29.5	1.2	-2.4	-3.8	-1.1	-3.1	-1.5	-2.6	-1.8	-2.8	-0.9	-2.8	1.9	-3.9	-1.1	-2.0	-5.4	-3.1	-5.1	-4.0
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.6	-0.9	-1.6	-1.3	-1.4	-0.8	-1.2	-1.4	-0.8	-1.2	-1.2	-0.5	-0.6	-1.1	-1.3	-0.1	-0.6	-1.2	-0.2	-1.0
Headache pain in last month	0.9	1.5	3.3	0.6	1.4	0.4	1.2	1.5	1.5	1.1	1.1	1.5	1.2	0.9	1.2	1.7	1.0	0.5	1.8	1.5	0.4	1.2
Qualifications: College or University degree	0.9	3.0	19.1	1.2	-1.2	-1.1	-0.7	-1.4	-1.1	-1.3	0.6	-1.4	-1.1	-1.0	0.2	-1.9	-0.5	0.4	-2.8	-1.9	-4.4	-2.9
Neck or shoulder pain in last month	0.9	1.2	6.0	0.4	-0.5	-1.2	-0.6	0.1	-0.1	-0.5	-0.9	-0.3	0.6	-1.0	0.6	-0.8	0.1	-2.0	-2.5	-1.4	-1.7	-1.6
Angina (self-reported)	0.9	1.2	2.8	-1.0	-1.4	-0.5	-1.1	-1.1	-1.2	-0.8	-1.2	-1.2	-1.0	-0.9	-1.3	-1.4	-1.3	-0.2	-1.0	-1.7	-0.6	-1.1
Pulse rate, automated reading	0.9	2.8	7.3	-0.8	1.5	1.7	2.7	1.4	2.5	2.0	1.9	1.6	1.0	2.4	1.5	1.7	0.5	0.4	1.0	1.7	-1.6	1.7
Comparative height size at age 10	0.9	4.8	10.7	1.1	-2.4	-2.4	-1.4	-2.6	-1.8	-2.4	-1.9	-2.6	-1.8	-2.6	0.1	-3.0	-0.7	-0.8	-3.3	-2.4	-2.8	-2.4
Qualifications: NVQ or HND or HNC or equivalent	0.9	1.1	5.2	0.3	-1.0	-0.3	-1.1	-0.9	-0.7	-1.3	-1.4	-1.1	-0.4	-0.6	-1.1	-1.4	-0.2	-0.3	-2.3	-1.3	-1.4	-0.5
Illnesses of father: None of the above (group 1)	0.9	1.2	6.1	-2.1	0.1	2.0	0.7	0.6	0.3	0.7	1.7	0.3	0.5	2.5	0.2	0.4	-1.4	-0.1	-0.5	0.1	0.2	-0.4
Ever had prostate specific antigen (PSA) test	0.9	1.1	4.7	1.6	-0.3	-1.2	-1.4	-0.9	-1.2	-1.7	-0.9	-0.9	-0.4	-2.2	-0.8	-0.9	0.6	1.2	-0.4	0.2	-0.2	0.2
Age started oral contraceptive pill	0.9	1.1	6.0	2.4	0.3	-0.6	-0.3	0.0	0.3	0.1	-0.3	0.1	0.8	-0.9	0.7	-0.3	1.2	-2.4	-1.3	-0.9	-0.9	-1.4
Commuting to job workplace: Cycle	0.9	1.1	3.2	0.7	1.6	0.6	0.9	0.6	0.8	0.7	1.2	1.1	0.6	0.2	1.3	1.1	0.9	1.8	1.1	1.6	0.5	1.2
Basal cell carcinoma (self-reported)	0.9	1.1	4.8	0.4	0.9	-0.2	-0.3	0.5	0.1	-0.1	-0.1	0.4	0.0	-0.1	0.2	1.1	0.6	2.2	1.8	1.6	1.7	1.8
Ovarian Cancer	0.8	1.0	3.6	0.5	1.2	1.9	0.6	0.6	1.5	1.2	1.2	0.9	1.6	0.8	0.8	1.3	0.6	-1.2	0.5	0.3	0.5	0.5
Diabetes (mother)	0.8	1.0	3.1	0.5	1.4	1.8	0.7	0.8	1.0	1.1	0.3	1.1	0.7	0.7	0.3	1.7	1.1	-0.1	1.0	1.5	-0.3	1.1
Taking other prescription medications	0.8	1.3	3.7	-0.4	-1.2	-1.4	-1.6	-0.6	-1.9	-0.9	-1.3	-0.8	-0.8	-1.9	-0.7	-0.8	-0.9	-0.7	-0.3	-1.5	-0.1	-1.2
Number of full sisters	0.8	1.0	3.9	0.1	1.0	0.0	0.4	0.3	0.6	1.2	0.4	1.0	0.4	0.8	1.4	1.5	0.5	-0.1	0.7	1.9	1.5	2.0
Suffer from ‘nerves’	0.8	1.3	3.3	-0.6	-1.2	-1.0	-0.9	-1.1	-0.3	-0.7	-1.6	-1.2	-1.1	-0.4	0.4	-1.1	-1.5	0.1	-1.6	-1.5	-1.8	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.8	6.5	-0.5	-1.2	-1.9	0.2	-1.2	-0.3	-0.8	-0.5	-1.1	-0.4	0.0	1.2	-1.8	-1.0	-0.7	-2.5	-1.5	-2.4	-2.0
Fasting Glucose	0.7	0.8	2.2	1.5	0.3	0.9	0.8	0.7	1.2	0.3	1.3	0.7	0.1	0.9	-0.6	0.6	1.4	-0.0	1.2	0.4	1.3	0.9
Triglycerides	0.7	1.1	2.9	-0.6	1.0	1.0	1.1	1.1	1.1	1.7	0.9	1.2	0.7	0.9	1.5	1.7	0.2	-0.0	0.5	1.3	-0.3	1.2
Chronotype (morning person)	0.7	1.5	6.2	0.1	1.2	2.2	1.0	0.8	0.9	1.1	1.3	1.0	1.1	1.1	0.2	1.4	0.9	0.5	2.5	0.9	1.5	1.4
Ever used hormone-replacement therapy (HRT)	0.7	0.9	3.0	1.6	0.7	-0.6	-0.6	0.5	-0.1	0.2	-1.1	0.3	0.1	-1.0	-0.7	0.7	1.3	0.4	1.6	0.9	1.7	1.3
Fed-up feelings	0.7	1.3	3.7	0.3	1.4	0.5	0.4	1.0	0.9	1.4	0.7	0.9	0.6	1.2	1.4	1.7	0.8	1.9	0.7	1.5	-0.5	1.9
Number of incorrect matches in round	0.7	1.2	4.2	0.6	0.9	0.0	1.1	1.0	1.5	0.7	0.9	1.3	1.8	0.4	2.0	0.4	1.0	-1.3	-1.1	-0.3	-1.3	-1.0
Had other major operations	0.7	0.9	6.8	0.2	-0.7	-0.7	-0.6	-0.8	-0.6	-1.1	-0.4	-0.8	-1.4	-1.5	-0.1	-0.7	-0.5	2.6	0.3	-0.4	-0.7	-0.3
Fluid intelligence score	0.7	1.5	3.1	-0.9	-1.3	-1.0	-1.8	-1.4	-1.7	-1.4	-1.1	-1.3	-1.5	-1.2	-0.7	-1.2	-1.4	1.3	0.5	-1.0	-0.1	-1.0
Arm fat percentage (right)	0.7	2.7	6.3	0.1	1.2	1.6	1.9	2.1	1.2	1.5	2.5	2.0	2.5	1.5	1.9	1.4	1.6	-1.5	-2.1	0.0	-1.6	0.1
Time employed in main current job	0.7	0.8	4.0	-0.7	0.7	1.2	0.1	0.6	0.8	0.9	0.3	0.9	0.4	0.6	0.2	1.0	-0.1	-0.2	2.0	1.0	1.7	0.6
Hair/balding pattern: Pattern 3	0.7	1.1	2.3	1.5	-0.6	-1.5	-1.1	-0.3	-1.4	-0.8	-1.5	-0.9	0.0	-1.4	-0.1	-1.2	0.4	-0.7	-1.2	-1.3	-0.2	-1.4
Medication: Seretide 50 evohaler	0.7	0.9	2.4	-0.2	-1.1	-1.1	-1.3	-0.8	-1.6	-0.6	-0.6	-0.9	-1.0	-0.9	-1.1	-0.7	-0.9	-0.5	-0.8	-1.0	-0.3	-1.2
Commuting to job workplace: Car/motor vehicle	0.7	0.9	2.5	0.3	-0.6	0.3	-1.5	-0.7	0.0	-1.1	-0.8	-0.9	-1.0	-1.5	-1.6	-0.4	-0.1	-0.6	1.3	-0.4	1.5	-0.2
Mineral and other dietary supplements	0.7	1.0	5.2	-2.3	-1.1	0.7	-0.8	-0.9	-0.7	-0.9	-0.7	-0.8	-1.2	0.1	-0.8	-0.6	-1.9	0.7	0.8	-0.5	0.7	-0.5
Tinnitus: Yes, now most or all of the time	0.7	0.9	2.9	-1.1	-0.6	-0.1	-1.2	-0.5	-1.3	-0.3	-1.6	-0.6	-1.0	-0.8	-1.7	-0.2	-0.8	1.7	0.6	-0.4	-0.0	0.4
Crohns Disease (2012)	0.6	0.9	3.4	1.3	1.2	1.0	0.7	0.0	0.0	0.4	-0.3	0.4	0.2	0.8	0.3	0.7	1.4	1.1	1.2	1.9	0.3	1.8
Blood Red Count	0.6	5.7	22.2	0.1	-2.3	-4.7	-2.1	-2.7	-2.1	-2.4	-3.0	-2.5	-2.2	-2.4	-2.7	-3.1	-2.0	-1.6	-0.2	-2.1	-0.2	-2.4
Frequency of depressed mood in last 2 weeks	0.6	0.8	2.0	-0.6	-0.7	-0.4	-1.3	-1.3	-0.5	-0.4	-1.3	-1.2	-1.3	-0.5	-0.3	-0.7	-1.3	1.4	0.6	-0.5	-0.2	-0.5
Stomach or abdominal pain in last month	0.6	0.7	3.3	1.1	0.2	-1.2	0.5	0.9	1.3	0.0	0.1	0.6	0.7	0.5	0.7	-0.1	0.9	-0.3	-1.0	-0.6	-1.8	-1.0
Hearing difficulty/problems with background noise	0.6	1.0	3.0	-1.7	-0.8	-0.3	-1.7	-0.6	-1.7	-0.9	-0.9	-0.6	-1.0	-1.4	-0.1	-0.2	-1.4	0.6	0.7	-0.2	1.2	0.2
Had menopause	0.6	0.8	3.7	1.0	0.9	0.0	0.7	0.5	1.9	1.0	-0.2	0.6	0.9	1.0	0.6	0.9	0.7	-1.7	-0.1	0.6	0.4	0.2
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	5.1	-2.3	-0.2	1.4	0.3	0.8	0.7	0.1	1.3	0.2	0.2	1.4	-0.2	0.2	-1.4	0.5	0.9	-0.4	0.2	-0.7
Hip circumference	0.6	2.5	7.6	0.3	-1.6	-1.8	-1.5	-1.4	-1.8	-2.1	-1.0	-1.4	-0.1	-1.9	0.5	-2.1	-0.4	-0.5	-2.8	-1.8	-2.1	-1.9
Serious illness, injury or assault of a close relative in last 2 years	0.6	0.6	2.2	-1.0	-1.2	-0.5	-0.1	-0.7	-0.2	-0.9	-0.3	-0.9	-0.6	-0.4	-0.4	-0.8	-1.1	-0.4	-0.2	-1.5	0.7	-1.4
Depression (self-reported)	0.6	0.7	3.4	-1.0	0.3	1.9	1.2	0.4	1.0	0.8	1.1	0.6	0.4	1.0	1.1	0.8	-0.4	-0.3	-1.1	0.0	-0.6	0.2
Medication: Omeprazole	0.6	0.7	3.7	-0.6	-0.6	-1.9	-0.8	-0.1	-0.5	-0.6	-1.0	-0.2	-0.5	-1.3	-0.6	0.1	-0.4	-0.0	1.2	-0.1	1.3	0.2
Leg pain on walking	0.6	0.7	2.7	-0.3	-0.5	-1.4	-1.0	-0.5	-0.9	-0.4	-0.5	-0.8	-1.3	-1.0	-1.6	-0.4	-0.4	1.5	-0.6	-0.6	-0.5	0.1
Commuting to job workplace: Walk	0.6	0.6	2.0	-0.2	-0.7	-0.2	-0.6	-1.4	-1.2	-1.1	0.0	-1.0	-0.6	-0.6	-1.2	-0.9	-0.9	0.5	0.2	-0.7	0.1	-1.0
Breast cancer (self-reported)	0.6	0.7	3.2	-1.2	0.0	-0.9	-0.5	-0.8	-0.6	0.2	-0.7	-0.1	-0.6	-0.9	-0.3	0.1	-1.2	-0.5	1.8	0.5	1.7	0.3
Medication: Paracetamol	0.6	0.9	2.8	0.9	0.7	0.2	0.8	1.5	0.7	1.0	0.5	1.1	1.3	0.6	1.7	1.0	1.2	-0.9	-0.2	0.7	-0.1	0.7
Alcohol drinker status: Never	0.6	0.7	2.0	-0.2	-1.0	-0.3	-0.5	-0.9	-0.5	-0.7	-1.2	-1.1	-1.4	-0.8	-1.4	-0.7	-0.8	-0.6	-0.9	-0.7	0.5	-0.6
Depressed Affect (Nagel 2018)	0.5	1.1	5.5	-0.6	0.8	1.7	0.7	0.8	0.3	1.7	1.0	0.9	0.4	0.9	2.3	1.9	0.1	0.6	0.4	0.0	-0.2	1.1
Worry (Nagel 2018)	0.5	1.0	2.8	0.3	-1.2	-1.1	-0.7	-1.1	-0.6	-0.7	-1.2	-1.2	-1.0	-1.1	0.5	-0.8	-0.6	0.4	-1.4	0.0	-1.7	-1.5
Ulcerative Colitis (UC)	0.5	0.9	5.3	2.3	0.7	0.4	1.0	0.7	1.3	0.5	-0.1	0.6	0.7	-0.1	0.7	0.3	2.2	-0.5	0.5	0.0	0.8	0.7
HbA1C	0.5	0.5	1.7	1.3	1.0	-0.4	0.4	0.2	0.7	0.5	0.6	0.6	0.4	0.7	0.6	0.7	0.9	-0.4	-0.4	1.3	-0.8	0.4
BMI	0.5	2.6	11.0	1.3	-0.9	-0.3	-1.2	0.0	-1.2	-1.3	-0.1	-0.7	1.2	-0.9	1.2	-1.8	0.7	-0.9	-3.2	-2.4	-3.3	-2.5
Height	0.5	10.4	38.8	0.7	-2.6	-4.9	-0.7	-2.8	-1.7	-2.4	-1.9	-2.6	-0.4	-2.6	2.5	-4.2	-0.9	-2.5	-6.2	-3.5	-5.3	-4.8
Waist Hip Ratio (WHR)	0.5	2.4	6.7	-2.2	0.6	0.7	1.9	1.6	1.3	2.1	1.4	1.6	1.8	2.6	2.2	1.4	-1.0	-1.9	1.1	0.1	0.3	-0.2
Systolic Blood Pressure	0.5	2.5	8.6	-2.9	-1.0	-2.3	0.8	-0.3	1.7	-0.1	-0.3	-0.4	0.2	1.7	0.0	-1.5	-2.2	-1.6	-0.1	-1.9	-2.9	-2.1
Cardiovascular Disease	0.5	1.7	7.0	-1.4	-1.0	-1.9	0.4	0.1	0.4	-0.1	-0.4	-0.2	0.4	1.1	0.5	-1.3	-1.2	-2.6	-1.1	-1.8	-1.6	-2.5
Supplements: Zinc	0.5	0.5	1.4	0.8	0.7	0.3	0.9	0.8	0.3	0.8	0.7	0.6	0.7	1.1	1.2	0.6	0.5	-0.2	0.1	0.9	-0.7	0.5
Trunk fat percentage	0.5	2.1	7.2	0.6	1.0	0.6	1.7	1.5	0.6	1.0	1.4	1.5	2.3	1.0	2.4	0.9	1.5	-1.7	-2.7	0.2	-1.7	0.1
Townsend deprivation index at recruitment	0.5	0.7	3.1	0.7	0.9	-0.9	1.8	0.7	0.1	0.7	0.4	1.1	1.0	0.8	0.6	0.4	1.0	-1.0	-0.5	1.0	-0.7	0.4
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.8	-1.2	-1.7	0.4	-0.6	-1.0	-0.4	-1.5	0.3	-1.3	-1.3	-0.3	-0.8	-1.2	-1.4	1.3	0.2	-1.4	-0.3	-1.2
Multivitamins +/- minerals	0.5	0.6	1.8	1.1	0.5	0.5	0.8	1.1	0.4	0.9	0.4	0.7	1.1	0.5	1.0	0.7	1.3	-0.3	-0.7	0.2	-0.3	0.3
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	3.5	-1.0	0.1	-0.8	0.1	-0.4	-0.1	-0.2	-0.6	-0.1	-0.2	0.8	0.3	-0.3	-0.6	0.8	1.9	0.7	1.7	0.3
Hair/balding pattern: Pattern 2	0.5	0.7	3.0	-1.0	0.8	0.2	0.5	0.2	0.4	0.7	0.3	0.5	-0.1	0.2	-0.4	0.7	-0.3	1.0	1.7	1.1	1.5	1.2
Allergy	0.5	1.1	3.3	1.2	1.7	0.3	0.6	0.9	1.1	1.2	0.0	1.1	1.0	0.8	0.2	1.1	1.4	-0.5	0.5	1.8	0.3	1.5
Medication: Ramipril	0.5	0.7	3.0	-1.2	-0.8	0.5	-0.5	-0.3	0.1	-0.5	0.9	-0.5	-0.3	0.4	-0.3	-0.5	-1.1	-1.2	-0.6	-1.3	-0.3	-1.7
Worrier / anxious feelings	0.5	1.0	3.6	0.8	-1.0	-1.9	-0.7	-0.6	-0.7	-0.7	-0.9	-0.8	-0.3	-1.4	0.4	-0.9	-0.1	-0.4	-0.9	-1.4	-1.2	-1.6
Forced expiratory volume in 1-second (FEV1)	0.5	1.6	8.0	1.1	-0.1	-1.7	1.5	0.0	1.2	-0.4	0.5	0.0	1.1	-0.1	1.9	-1.1	0.9	-1.4	-1.8	-1.0	-2.8	-1.4
Qualifications: A levels/AS levels or equivalent	0.5	1.0	9.7	-0.9	-0.2	0.7	-0.0	-0.1	-0.2	-0.1	1.0	-0.2	-0.2	0.8	0.3	-0.3	-0.8	3.1	0.0	-0.6	-2.2	-0.8
Medication: Lansoprazole	0.5	0.5	1.6	-1.0	-0.6	0.5	-0.7	0.2	-0.2	0.1	0.7	-0.1	0.5	-0.5	0.1	0.1	-0.7	-1.1	-1.3	-1.2	-0.7	-1.1
Exposure to tobacco smoke at home	0.5	0.6	2.3	1.2	0.6	-0.8	0.3	0.9	1.4	0.2	0.4	0.8	1.1	0.3	1.0	-0.0	1.5	0.2	-0.5	0.1	0.1	0.4
Breastfed as a baby	0.5	0.6	1.5	-0.3	-0.7	-0.9	-0.8	-1.0	0.1	-0.8	-0.8	-0.9	-0.6	-1.0	-0.2	-1.1	-0.8	-0.6	-1.2	-1.0	0.1	-1.0
Tense / ‘highly strung’	0.5	0.8	2.5	0.0	-1.0	-1.1	-0.3	-0.8	-0.2	-0.5	-0.6	-0.9	-0.9	-0.8	0.7	-0.5	-0.5	0.8	-1.6	-1.0	-1.6	-0.8
Body fat percentage	0.5	1.9	6.5	0.5	0.8	0.6	1.6	1.5	0.5	1.0	1.3	1.4	2.3	0.8	2.2	0.8	1.6	-1.8	-2.5	-0.0	-1.4	0.1
Number of children fathered	0.5	0.5	2.4	0.5	0.9	0.1	0.0	0.6	0.5	0.4	-0.3	0.5	0.3	-0.5	-0.6	0.7	0.9	0.0	0.5	1.1	1.5	1.5
Health satisfaction	0.5	0.6	1.8	-0.7	-0.5	-1.3	-1.2	-0.7	-0.9	-0.4	-0.8	-0.8	-0.7	-0.4	-0.8	-1.0	-1.3	-0.1	-0.6	-0.6	0.3	-0.8
Overall health rating	0.5	1.1	2.5	-0.5	-1.1	-0.7	-1.4	-0.3	-1.2	-0.8	-1.1	-0.8	-0.6	-0.5	-1.1	-1.5	-0.9	-0.4	-1.6	-1.5	-1.6	-1.0
Supplements: Vitamin C	0.5	0.6	1.6	0.7	1.3	0.9	0.8	1.0	0.8	1.1	0.2	0.9	0.3	0.7	0.4	0.6	0.7	-0.0	0.5	1.2	0.4	1.0
Arm fat percentage (left)	0.5	1.9	5.0	0.0	0.7	1.4	1.4	1.6	0.6	1.0	2.1	1.4	2.1	1.1	1.6	0.9	1.2	-1.2	-2.2	-0.4	-1.9	-0.3
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	4.4	-0.8	-1.3	-2.1	-0.5	-0.7	-0.2	-0.7	-0.5	-0.6	-0.5	-1.0	-0.3	-0.6	-0.9	-0.5	0.6	-1.0	0.5	-1.1
Medication: Aspirin	0.5	0.6	2.0	-1.4	-0.3	0.2	-1.0	-0.5	-0.5	0.0	-0.9	-0.5	-1.3	-0.1	-1.2	0.0	-1.3	0.4	0.9	0.3	1.0	0.1
Average weekly champagne plus white wine intake	0.5	0.7	2.0	0.3	0.9	1.2	0.3	0.6	-0.2	0.6	0.9	1.1	0.7	-0.1	1.3	1.1	0.9	0.7	0.4	1.4	0.7	1.2
Medication: Blood pressure	0.5	0.9	4.0	0.3	-0.4	-1.8	-0.2	0.4	0.1	-0.2	-0.1	-0.0	0.6	-0.1	0.1	-0.9	0.1	-2.0	-0.7	-1.5	-0.8	-2.0
Supplements: Fish oil (including cod liver oil)	0.5	0.6	4.7	2.2	0.6	-0.6	0.2	0.3	0.6	0.3	0.0	0.1	0.8	-0.5	-0.0	-0.2	1.6	-0.8	-1.0	-0.2	-0.7	-0.0
Medication: Bendroflumethiazide	0.5	0.8	3.2	-1.2	-0.7	-1.8	-0.3	-0.4	0.3	-0.3	-0.6	-0.4	0.3	0.2	-0.4	-0.9	-0.8	-1.4	0.8	-1.2	1.3	-1.2
Medication: Atorvastatin	0.5	0.6	2.1	-0.6	0.4	1.5	1.0	0.1	0.3	0.4	0.4	0.6	-0.4	0.2	-0.9	1.1	-0.2	-0.3	1.4	1.1	0.7	0.9
Irritability	0.5	0.8	4.3	-2.1	-1.1	0.7	0.1	-0.1	-0.1	0.2	0.1	-0.4	-0.1	-0.0	1.2	0.1	-1.6	-0.4	-0.4	-1.3	-0.8	-1.3
Myopia	0.5	0.7	4.9	0.6	0.0	-2.2	0.9	0.3	0.0	0.5	0.9	0.3	0.5	-0.2	1.0	-0.1	0.3	-1.1	-1.5	-0.2	-0.8	-0.6
Vascular/heart problems diagnosed by doctor	0.5	1.3	5.3	1.0	1.3	2.3	0.7	0.7	0.3	0.6	1.2	0.8	0.8	0.2	0.8	1.3	1.0	1.6	0.4	1.6	0.8	1.7
Leg fat mass (left)	0.5	1.8	8.7	0.2	-1.4	-1.3	-0.9	-0.6	-1.5	-1.3	-1.0	-0.9	0.4	-1.6	1.0	-1.6	0.2	-0.8	-3.0	-1.8	-1.8	-1.4
Alzheimer’s Disease (in mother)	0.4	0.5	1.2	0.8	-0.6	-0.6	-1.0	-0.5	-0.6	-0.9	-0.0	-0.8	-0.4	-0.8	-0.9	-0.5	-0.1	1.0	0.5	-1.1	0.3	-1.1
Reaction Time	0.4	0.8	2.6	-0.1	0.2	0.6	1.1	0.8	1.0	0.4	1.4	0.6	0.7	1.6	-0.1	0.0	0.4	-0.2	0.4	-1.0	-1.5	-1.4
Primary Biliary Cirrhosis	0.4	0.5	5.2	0.9	0.1	-0.4	1.4	-0.6	0.2	0.2	0.7	0.1	0.4	0.2	0.3	0.2	0.8	-2.3	-0.5	0.3	-0.3	0.1
Neuroticism	0.4	0.9	3.1	-0.1	-1.3	-0.9	-0.9	-1.1	-0.4	-0.5	-1.7	-1.1	-1.0	-1.2	0.8	-0.8	-0.8	0.2	-0.7	-1.1	-0.8	-1.0
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.4	-1.0	-0.3	0.2	0.1	0.7	0.1	0.2	0.8	0.4	0.3	0.4	-0.0	-0.3	-0.7	-0.8	-1.1	-0.8	-0.5	-1.2
High blood pressure	0.4	1.1	5.4	-1.1	-1.1	-2.3	-0.3	-0.3	-0.0	-0.6	-0.8	-0.6	-0.5	-0.2	-0.3	-1.3	-0.9	-1.4	-0.2	-1.6	-0.7	-1.7
Sitting height	0.4	2.5	12.1	2.4	-0.2	-2.5	0.1	-1.4	-0.4	-0.7	-0.7	-0.8	0.1	-1.6	2.7	-1.0	0.8	-0.3	-2.9	0.5	-3.5	-0.2
Diabetes (self-reported)	0.4	0.6	1.6	1.1	0.8	-0.4	1.1	0.9	0.3	0.9	0.7	0.9	0.7	-0.2	0.8	0.7	1.3	0.1	-0.6	0.5	-1.2	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.6	2.1	-0.1	-0.5	-0.8	-1.1	0.2	-0.7	-0.1	-0.9	-0.4	-0.2	-1.0	-0.1	-0.8	-0.2	-0.2	-1.0	-1.2	-1.5	-0.9
Number of live births	0.4	0.6	2.0	-1.2	0.3	0.8	0.5	1.0	0.3	0.7	0.4	0.8	1.0	0.1	0.4	0.8	-0.2	-0.3	1.4	0.0	1.4	0.2
Length of working week for main job	0.4	0.4	2.9	-0.8	-0.4	-0.6	-0.1	0.2	-0.0	-0.2	0.4	0.3	0.8	0.1	-0.5	-0.2	-0.5	-1.7	-0.2	-0.8	0.3	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	2.3	0.9	-0.7	-0.2	-1.2	-0.4	-1.5	-0.6	-0.1	-0.6	-1.2	-1.3	-0.5	-0.1	0.0	-0.3	-0.7	-0.8	-0.5	-0.6
Qualifications: O levels/GCSEs or equivalent	0.4	0.6	3.7	-0.5	0.5	-0.4	0.1	0.5	0.5	0.7	0.9	0.5	0.2	1.3	0.3	0.4	-0.0	1.9	0.3	0.1	-1.5	-0.3
Medication: Paracetamol	0.4	0.7	2.2	1.0	0.6	-0.2	0.4	1.3	0.4	0.9	-0.0	1.0	1.0	0.3	1.5	0.8	1.1	-1.0	-0.3	0.6	-0.7	0.5
Eye problems/disorders: None of the above	0.4	0.5	1.7	0.1	-0.5	-1.0	-0.6	0.2	-0.9	-0.6	-0.3	-0.5	0.1	0.1	-0.4	-0.9	-0.1	0.8	-1.1	-1.3	-1.0	-1.0
Mouth/teeth dental problems: Loose teeth	0.4	0.5	1.2	-1.0	-0.2	-0.9	-0.9	-0.5	-0.6	-0.6	-0.6	-0.6	-0.6	-0.4	-0.7	-0.6	-1.1	0.5	-0.8	-0.1	-0.8	-0.0
Whole body fat mass	0.4	1.5	11.2	0.5	-0.5	-0.7	0.0	0.1	-0.7	-0.5	0.1	-0.0	1.3	-0.8	1.7	-0.8	0.7	-1.3	-3.4	-1.2	-2.3	-1.1
Family relationship satisfaction	0.4	0.5	2.7	-0.3	-0.0	-0.3	-0.2	-0.3	-0.3	-0.2	0.3	-0.3	-0.2	0.5	0.1	-0.8	-0.9	-0.1	-1.0	-0.8	-1.3	-1.6
Hypertension (Self-reported)	0.4	1.2	6.7	-1.1	-1.2	-2.6	-0.4	-0.3	-0.0	-0.8	-1.1	-0.6	-0.3	-0.2	-0.2	-1.5	-0.9	-1.5	0.1	-1.8	-0.4	-1.9
Smoking status: Previous	0.4	0.6	1.5	0.5	-1.1	0.4	-1.1	-0.9	-0.9	-1.2	-1.1	-1.0	-0.6	-0.8	0.0	-1.2	0.1	-0.7	-0.9	-0.7	0.1	-0.0
Mood swings	0.4	0.7	2.5	1.1	0.6	0.7	0.7	0.7	0.5	1.1	0.8	0.7	0.5	0.2	1.6	1.2	1.2	0.2	-0.4	0.4	-1.5	0.2
Loneliness, isolation	0.4	0.5	1.7	0.3	0.5	0.8	-0.2	0.5	-0.1	0.8	0.4	0.5	-0.2	-0.1	1.0	1.0	0.3	1.3	0.8	1.0	0.7	1.1
Long-standing illness, disability or infirmity	0.4	0.6	1.9	-1.0	-1.0	-0.6	-0.9	-0.1	-0.6	-0.1	-0.5	-0.2	-0.6	-0.6	-0.8	-0.5	-1.1	-1.4	-0.5	-1.0	0.3	-1.1
Diabetes diagnosed by doctor	0.4	0.7	4.6	1.0	0.7	-0.3	1.1	0.7	0.2	0.8	0.7	0.8	0.5	-0.0	0.9	0.6	0.9	0.1	-0.8	0.4	-2.1	0.1
Medication for cholesterol	0.4	0.6	3.8	-0.4	-0.3	1.2	-0.3	-0.7	-0.3	-0.3	-0.1	-0.5	-0.9	0.3	0.2	0.3	-0.4	1.9	1.0	0.6	1.0	1.1
Asthma (self-reported)	0.4	0.7	2.2	-0.8	0.4	0.2	0.9	1.0	0.3	1.0	1.5	1.0	1.0	1.0	1.4	0.6	-0.3	-0.9	-0.3	-0.5	0.9	-0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	3.5	-0.7	-0.8	-1.9	-0.8	-0.4	-0.1	-1.2	-1.4	-0.8	-0.6	-1.4	-1.0	-1.0	-0.7	0.0	1.4	-0.5	1.1	-0.4
Fractured/broken bones in last 5 years	0.4	0.5	2.5	0.9	-0.2	0.1	-0.2	-0.4	0.2	-0.3	-0.8	-0.3	0.1	-0.2	0.9	-0.9	0.6	0.1	-1.6	-0.3	-1.6	0.3
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	2.0	-0.7	0.3	-0.5	-0.3	0.6	-0.3	0.4	-0.3	0.6	-0.1	-0.5	-0.5	1.0	-0.1	0.7	1.4	0.8	1.4	1.3
Crohns Disease (2017)	0.3	0.6	2.0	0.7	-0.1	-1.0	-1.0	-0.8	-0.6	-0.6	-1.4	-0.7	-0.7	-0.8	-0.8	-0.5	0.3	0.9	0.6	0.0	1.1	0.3
Breast Cancer	0.3	0.7	3.3	-0.4	1.0	0.0	1.0	0.9	0.2	0.8	0.5	1.0	0.7	0.2	1.8	0.7	0.6	-0.4	-0.4	1.2	0.8	0.8
Body Mass Index (BMI) (2010)	0.3	0.4	2.0	1.2	-0.1	-1.4	-0.5	-0.0	-0.5	-0.4	-0.8	-0.2	-0.1	-0.8	-0.4	-0.3	0.9	0.4	-0.9	-0.1	-0.6	0.4
Blood White Count	0.3	2.4	6.3	0.6	2.0	0.4	2.5	1.8	2.2	1.4	0.6	1.9	2.3	2.2	2.4	0.9	1.2	-1.2	0.1	1.2	-0.2	0.4
Allergy or Eczema	0.3	0.9	4.8	-1.0	-1.0	0.8	-0.8	-0.8	-0.3	-1.1	0.2	-1.0	-1.2	-0.4	-0.9	-0.5	-0.9	2.2	1.1	-0.6	0.8	-0.3
Respiratory disease	0.3	0.7	2.0	-1.0	-0.8	0.1	-0.8	-1.0	-1.2	-0.5	-0.1	-0.7	-0.8	-0.9	-0.1	-0.6	-1.4	-0.7	0.1	-1.1	1.4	-1.1
Hand grip strength (left)	0.3	0.7	3.8	1.1	0.3	0.6	0.5	-0.3	-0.2	-0.1	-0.2	-0.2	0.2	0.4	1.1	-0.3	0.7	1.9	-0.9	0.3	-1.9	0.6
Ever had hysterectomy (womb removed)	0.3	0.4	1.4	0.2	-0.5	0.8	-0.9	-0.1	-1.1	-0.1	-0.7	-0.6	-0.0	-0.5	-0.3	-0.5	-0.2	-0.0	-0.6	-1.2	-0.4	-1.0
Systolic blood pressure, automated reading	0.3	0.8	2.9	-1.0	-0.8	-1.4	-0.2	-0.4	1.4	-0.5	-1.0	-0.6	-0.2	0.4	-0.3	-1.3	-0.8	-0.2	-0.0	-1.3	-1.7	-0.9
Vitamin and mineral supplements	0.3	0.4	1.6	-0.8	-0.6	-0.5	-0.5	-0.9	-0.8	-0.7	-0.3	-0.6	-0.9	-0.4	-0.5	-0.3	-0.6	1.3	0.3	0.0	0.1	0.3
Current tobacco smoking	0.3	0.4	2.1	-1.5	-0.3	0.9	-0.4	-0.1	-0.4	-0.1	-0.1	-0.5	-0.5	-0.5	-0.8	-0.2	-1.3	0.7	-0.4	-0.6	-0.9	-0.3
Average weekly fortified wine intake	0.3	0.4	3.5	-0.4	0.1	-1.9	0.2	-0.2	-0.1	0.0	-0.1	0.1	0.5	-0.1	0.4	-0.2	-0.2	-1.5	-0.4	-0.3	0.4	-0.5
Relative age voice broke	0.3	0.5	3.0	0.3	-0.1	-0.1	-0.4	0.1	-0.5	-0.1	0.6	0.1	0.3	-0.1	-0.4	-0.4	0.1	-1.4	-1.0	-1.2	-1.2	-1.7
Age when periods started (menarche)	0.3	0.6	3.7	1.6	-0.1	-0.7	0.0	0.1	-0.1	-0.4	0.4	0.1	0.4	-1.0	-0.2	-0.3	0.8	-1.1	-1.9	-0.7	-0.8	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	3.9	1.5	0.9	2.0	-0.2	0.0	0.3	0.6	0.5	0.5	-0.0	-0.1	-0.7	0.9	1.1	0.9	0.7	1.3	0.3	1.3
Supplements: Glucosamine	0.3	0.4	1.9	1.0	0.5	-0.1	0.0	0.1	0.1	0.2	0.2	0.4	-0.3	-0.3	0.6	0.7	0.4	1.2	0.8	1.4	0.7	1.1
Medication: Atenolol	0.3	0.4	2.7	-0.1	-0.9	-1.6	0.2	-0.2	0.9	-0.4	-0.7	-0.4	-0.4	-0.5	0.3	-0.5	-0.2	-1.0	-0.0	-0.6	0.1	-0.5
High blood pressure (mother)	0.3	0.4	2.7	1.0	-0.5	-0.6	-0.0	-0.5	-0.5	-0.7	0.0	-0.4	-0.4	-0.8	-0.5	-0.8	0.4	-0.1	-0.6	-0.5	-1.6	-0.5
Trunk fat mass	0.3	1.5	10.4	0.4	-0.3	-0.5	0.3	0.2	-0.5	-0.2	0.3	0.2	1.4	-0.4	2.0	-0.6	0.7	-1.3	-3.2	-1.0	-2.3	-1.0
Waist circumference	0.3	1.2	3.7	-0.7	-1.0	-1.2	-0.5	-0.3	-0.9	-0.8	-0.2	-0.3	0.9	-0.8	1.4	-1.1	-0.4	-1.3	-1.9	-1.6	-1.5	-1.6
Forced vital capacity (FVC)	0.3	1.1	4.5	0.2	-0.0	-1.4	1.4	0.1	0.9	-0.2	0.7	0.2	1.0	0.3	1.8	-0.8	0.5	-1.3	-1.5	-0.7	-2.1	-1.0
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.9	-0.4	-0.3	-0.4	-0.3	-0.2	0.1	-0.2	-0.5	-0.4	-0.2	-0.7	0.2	-0.5	-0.7	0.1	-1.1	-0.9	-1.0	-1.4
Medication: Simvastatin	0.3	0.4	1.9	-0.2	-0.2	-0.3	-0.6	-0.2	-0.7	-0.5	-1.1	-0.5	-0.3	-0.4	-0.7	-0.7	-0.2	-1.1	-1.4	-0.6	-0.4	-0.8
Prospective memory result	0.3	0.4	2.4	-0.8	0.1	0.4	-0.1	0.0	-0.2	0.6	-0.6	-0.1	0.3	0.8	0.1	0.0	-0.8	-1.3	0.0	-0.2	1.6	-0.1
Illnesses of mother	0.3	0.4	2.1	-1.5	0.1	0.3	0.3	0.6	0.5	0.6	0.3	0.4	0.5	1.2	0.4	0.0	-0.7	0.4	0.4	0.0	0.8	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	3.8	0.5	-0.3	-1.9	1.3	-0.2	0.9	-0.5	0.6	-0.1	0.8	-0.4	1.1	-1.1	0.4	-1.6	-0.5	-1.1	-1.9	-1.5
Arm fat mass (right)	0.3	1.3	9.2	0.3	-0.4	-0.2	-0.1	0.2	-0.6	-0.4	0.5	0.1	1.1	-0.7	1.4	-0.6	0.6	-1.0	-3.0	-1.4	-2.5	-1.2
Ever highly irritable/argumentative for 2 days	0.3	0.4	2.7	-0.6	0.2	1.6	0.5	-0.2	1.0	0.6	1.0	-0.1	0.1	-0.5	0.3	0.4	-0.4	-0.5	-0.4	-0.5	-0.3	-0.7
Forced vital capacity (FVC), Best measure	0.3	1.0	2.9	0.2	0.5	-1.4	1.7	0.5	1.2	0.3	1.2	0.6	1.4	0.4	1.5	-0.3	0.7	-1.1	-0.4	-0.4	-1.7	-0.5
Comparative body size at age 10	0.3	0.7	2.2	0.3	-0.6	-0.8	-0.2	0.5	-0.7	-0.8	0.0	-0.2	0.6	-0.0	0.9	-1.2	0.3	1.1	-1.1	-1.5	-1.5	-1.1
Worry too long after embarrassment	0.3	0.6	4.2	0.3	-0.3	-2.0	-1.1	-0.3	-1.1	-0.3	-1.2	-0.4	-0.4	-0.5	-0.5	-0.6	-0.2	-0.4	-0.1	-0.4	-0.6	-0.9
Medication for pain relief, constipation, heartburn	0.3	0.6	2.4	-0.2	0.6	1.1	1.1	-0.1	0.8	0.4	1.5	0.4	0.3	0.9	-0.2	0.5	0.0	-0.1	1.0	0.7	1.1	0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.3	0.4	4.3	-0.6	-0.2	0.7	-0.7	-0.4	-0.4	-0.5	-0.1	-0.5	-0.5	-0.1	-0.5	-0.2	-0.6	2.1	0.0	-0.1	-0.4	0.0
Leg fat mass (right)	0.3	1.2	6.6	0.5	-0.9	-1.0	-0.6	-0.2	-1.1	-0.9	-0.5	-0.5	0.7	-1.5	1.1	-1.1	0.6	-0.6	-2.6	-1.4	-1.7	-0.9
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.9	-0.1	0.2	1.4	-0.6	0.0	0.2	-0.2	1.1	0.1	-0.4	-0.1	-1.0	0.1	-0.3	-0.1	1.1	0.2	0.1	-0.2
Medication: Aspirin	0.3	0.4	1.7	-1.3	-0.0	0.2	-0.6	-0.2	-0.3	0.5	-0.8	-0.1	-1.0	0.3	-0.6	0.4	-1.0	0.6	0.7	0.7	0.8	0.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	2.2	0.0	-0.6	-0.9	0.2	0.2	0.1	0.3	-0.5	-0.0	-0.1	-0.4	-0.6	0.2	-0.3	-1.5	0.8	-0.7	0.4	-0.3
Illnesses of siblings: Diabetes	0.3	0.4	3.7	-0.6	0.1	-0.0	0.4	0.5	0.4	0.4	-0.0	0.2	0.1	-0.3	0.4	0.3	-0.4	-1.9	-0.5	-0.7	-0.1	-1.0
Handedness (chirality/laterality): Left-handed	0.3	0.4	1.6	-0.2	-1.2	0.4	-0.8	-0.2	-0.3	-0.9	-0.0	-0.5	-0.5	-1.3	0.1	-0.4	-0.3	0.3	0.2	-1.0	0.3	-0.2
Ever had bowel cancer screening	0.3	0.3	1.6	0.4	0.1	-0.8	-0.8	-0.1	-0.3	-0.5	-0.9	-0.1	-0.2	-1.2	-0.4	-0.4	0.1	-0.5	-0.1	0.3	1.1	0.2
Medication: Gliclazide	0.3	0.3	2.7	0.3	0.4	0.2	0.5	0.4	0.0	0.4	0.5	0.4	0.6	0.5	0.4	-0.0	0.1	-0.8	-0.7	-0.0	-1.6	-0.1
Smoking status: Current	0.3	0.5	1.3	-1.2	-0.4	0.8	-0.6	-0.3	-0.7	-0.4	-0.2	-0.7	-0.6	-0.9	-0.9	-0.4	-1.1	0.9	-0.2	-0.7	-0.9	-0.4
Arm fat mass (left)	0.3	1.3	8.5	-0.1	-0.7	-0.3	-0.4	-0.0	-0.9	-0.5	0.3	-0.2	0.9	-0.7	1.1	-0.8	0.2	-0.8	-2.9	-1.6	-2.5	-1.4
Illnesses of father: High blood pressure	0.3	0.4	4.1	0.2	-0.6	-0.2	0.3	-0.4	0.4	-0.2	-0.3	-0.2	-0.4	-0.2	-0.8	-0.2	0.1	0.0	2.0	-0.8	0.7	-0.4
Diastolic blood pressure, automated reading	0.3	0.8	2.3	-0.1	-1.0	-1.5	-0.8	-1.1	0.5	-0.8	-1.4	-1.2	-0.8	-0.6	0.5	-1.3	-0.7	0.9	0.3	-0.8	-1.2	-0.6
Bipolar Disorder or Schizophrenia	0.2	0.4	2.5	1.0	0.3	1.0	0.3	0.5	0.0	-0.1	1.6	0.2	0.6	-0.5	0.1	0.6	0.8	0.5	-0.4	0.0	-0.2	0.2
Schizophrenia (2018)	0.2	0.5	2.8	1.7	0.7	0.6	0.0	0.7	0.0	0.2	1.1	0.3	0.7	-0.7	0.1	0.5	1.4	0.7	-0.5	0.0	-0.7	0.2
Irritable Bowel Disease (IBD)	0.2	0.4	3.2	1.8	0.3	-0.4	0.2	-0.0	0.5	-0.1	-0.9	0.0	0.1	-0.5	0.1	-0.3	1.5	-0.2	0.6	0.0	0.9	0.3
Mean Putamen Volume	0.2	0.2	0.7	0.3	-0.6	-0.1	-0.5	-0.5	-0.3	-0.3	0.5	-0.3	-0.8	-0.6	-0.5	0.0	-0.3	-0.4	-0.1	0.0	0.5	-0.8
HDL Cholesterol	0.2	0.3	2.1	1.5	0.0	0.0	-0.6	-0.0	0.3	-0.3	0.3	-0.2	-0.1	-1.1	-0.4	-0.2	0.9	0.0	-0.4	-0.3	-0.7	-0.5
Neuroticism (2016)	0.2	0.3	1.1	1.0	-0.1	0.2	-0.7	-0.5	-0.5	-0.3	-0.8	-0.5	-0.9	-0.9	-0.5	0.4	0.5	0.6	0.4	0.0	0.2	0.1
Schizophrenia (2014)	0.2	0.5	3.1	1.8	0.6	0.9	-0.2	0.3	0.3	-0.1	0.7	0.1	0.5	-0.7	-0.3	0.7	1.4	0.7	0.4	0.0	0.7	0.7
Lung FVC	0.2	1.0	3.1	-1.0	0.3	-0.8	1.8	1.1	1.4	0.7	1.1	0.9	0.8	1.1	0.1	0.5	0.6	-0.5	1.7	0.4	1.2	1.1
Relative age of first facial hair	0.2	0.4	2.0	0.3	0.2	1.2	-0.8	-0.7	-1.1	-0.5	0.1	-0.3	-0.4	-0.7	-0.9	-0.1	-0.3	-0.1	1.4	-0.1	0.4	-0.3
Medication: Metformin	0.2	0.3	1.8	0.5	0.2	-0.6	0.1	0.2	-0.4	-0.0	0.5	0.2	0.3	-1.1	-0.1	0.1	0.3	0.0	-1.3	-0.4	-1.3	-0.4
Hand grip strength (right)	0.2	0.4	1.8	0.8	-0.2	-0.1	0.1	-0.8	-0.4	-0.6	-0.6	-0.7	-0.5	-0.0	0.5	-0.8	0.2	1.3	-0.7	0.0	-1.3	0.2
Bilateral oophorectomy (both ovaries removed)	0.2	0.2	1.1	0.5	-0.4	-1.0	-0.1	-0.4	0.0	0.1	-0.8	-0.3	-0.1	-0.7	-0.2	-0.0	0.2	-0.2	-0.1	-0.5	-0.3	-0.2
Body mass index (BMI)	0.2	0.9	2.3	-0.3	-1.1	-0.7	-1.3	-0.5	-1.5	-1.1	-0.7	-0.7	-0.1	-1.4	-0.2	-1.0	-0.1	0.1	-1.4	-1.3	-1.0	-0.9
Financial difficulties in last 2 years	0.2	0.3	0.8	-0.9	0.3	0.6	0.6	0.7	0.3	0.7	0.1	0.4	0.9	0.2	0.8	0.7	-0.1	0.2	-0.1	-0.3	0.6	-0.1
Neuroticism score	0.2	0.3	3.3	0.2	-0.1	-0.5	-0.3	0.1	0.3	0.5	-0.8	-0.1	0.1	-0.3	1.8	0.5	-0.1	0.1	-0.4	-0.3	-1.0	-0.4
Mouth/teeth dental problems: Dentures	0.2	0.4	2.1	-0.5	0.5	1.2	-0.4	0.4	-0.6	0.7	0.1	0.3	-0.2	0.1	-1.4	0.7	-0.2	0.3	0.4	0.5	0.3	0.8
Asthma	0.2	0.4	1.7	-0.6	0.1	0.2	0.7	0.6	0.2	0.8	1.3	0.7	0.7	0.8	1.1	0.5	-0.3	-0.6	-0.2	-0.6	0.7	-0.7
Birth weight of first child	0.2	0.4	3.1	-0.1	-0.0	1.2	0.1	0.3	0.2	-0.3	0.7	0.1	0.4	-0.6	1.8	0.1	0.1	0.8	-0.9	0.3	-0.9	0.5
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.1	1.0	-0.2	0.2	-0.5	-0.1	-0.3	-0.4	-0.2	-0.3	0.1	-0.7	0.4	-0.6	0.3	1.0	-0.4	-0.8	-1.0	-0.5
Medication: Amlodipine	0.2	0.3	0.9	0.7	0.7	-0.5	0.5	0.9	0.4	0.1	0.4	0.6	0.9	0.7	0.0	-0.2	0.9	-0.2	-0.4	-0.3	-1.0	-0.4
Leg fat percentage (right)	0.2	0.8	3.1	1.0	0.1	-0.6	0.7	1.0	-0.2	0.2	-0.1	0.7	1.7	-0.6	1.4	0.1	1.7	-1.8	-1.3	-0.4	-0.2	0.2
Exposure to tobacco smoke outside home	0.2	0.2	1.2	-0.8	0.1	0.1	-0.1	0.5	-0.3	0.8	-0.1	0.3	0.3	0.3	0.0	0.4	-0.3	0.5	0.7	-0.0	1.1	0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.6	0.5	0.2	-0.2	0.5	0.8	0.4	0.4	0.6	0.6	0.1	0.4	0.3	0.5	0.1	-0.7	-0.6	-0.1	-0.6	-0.6
Wheeze or whistling in the chest in last year	0.2	0.3	0.7	-0.7	-0.1	-0.4	0.2	0.6	0.1	0.3	0.7	0.3	0.6	-0.3	0.7	0.5	-0.4	-0.9	-0.2	-0.7	0.6	-0.8
Medication: Blood pressure	0.2	0.3	1.1	-0.9	-0.1	-0.8	0.4	-0.3	0.8	0.1	-0.2	0.1	-0.4	0.3	-0.7	0.3	-0.4	-0.8	0.9	0.4	1.1	0.5
Mean time to correctly identify matches	0.2	0.5	2.7	-0.2	-0.4	-0.3	-0.0	0.2	0.2	-0.4	0.2	-0.1	0.0	0.4	-0.6	-0.9	0.2	-0.4	-0.2	-1.6	-1.2	-1.6
Chest pain or discomfort	0.2	0.2	1.0	-1.0	0.1	-0.2	0.4	-0.1	0.3	0.1	-0.7	0.1	-0.4	-0.2	-0.4	0.1	-0.7	-0.6	-0.7	0.0	-0.9	-0.1
Osteoporosis (self-reported)	0.2	0.3	0.8	-0.0	0.4	0.5	-0.3	0.9	0.6	0.0	0.8	0.4	0.8	0.0	-0.8	0.1	0.4	-0.6	0.2	-0.4	0.7	-0.1
Hearing aid user	0.2	0.2	0.8	0.1	0.3	-0.2	0.1	0.3	-0.5	0.5	-0.7	0.4	-0.2	-0.0	-0.0	0.2	0.2	-0.3	0.9	0.7	0.4	0.6
High cholesterol (Self-reported)	0.2	0.4	2.2	-0.7	-0.3	-0.6	-0.3	0.3	-0.8	-0.2	-0.3	-0.0	-0.0	-0.7	-0.5	-0.1	-0.6	-1.5	-0.9	-0.7	-0.5	-0.9
Leg fat percentage (left)	0.2	0.9	3.8	0.4	-0.6	-0.9	0.1	0.4	-0.8	-0.3	-0.8	0.1	1.3	-0.8	1.1	-0.6	0.9	-2.0	-1.9	-1.0	-0.4	-0.5
Number of operations (self-reported)	0.2	0.3	1.1	0.3	-0.3	-0.2	-0.3	-0.1	-0.6	-0.7	0.1	-0.3	-0.7	-1.0	-0.1	-0.1	0.2	1.0	-0.6	-0.4	-0.9	-0.1
Risk taking	0.2	0.3	1.0	0.8	-0.0	0.8	-0.8	0.1	-0.6	-1.0	-0.3	-0.2	0.2	-0.2	-0.5	-0.4	0.7	0.8	0.1	-0.5	0.2	-0.1
Unable to work because of sickness or disability	0.2	0.2	0.6	-0.6	0.2	0.5	0.0	-0.1	0.1	0.2	-0.4	0.1	-0.2	-0.3	-0.8	0.5	-0.2	-0.8	-0.7	0.7	0.4	0.5
Cholesterol lowering medication	0.2	0.3	1.3	-0.9	-0.0	0.1	0.1	0.6	-0.5	0.2	0.0	0.3	0.4	-0.3	-0.6	-0.0	-0.4	-1.1	-0.6	-0.5	-1.0	-0.7
Pain experienced in last month	0.2	0.3	1.0	-1.0	0.2	1.0	0.4	0.1	0.2	0.5	-0.0	-0.0	-0.2	0.8	-0.5	0.1	-0.5	0.4	0.7	0.3	0.1	0.6
Bipolar Disorder (2018)	0.1	0.2	1.3	-0.4	-0.3	1.1	0.4	-0.0	0.0	-0.2	1.2	-0.0	-0.2	0.0	-0.3	0.2	-0.3	0.1	-0.1	0.0	0.5	0.0
Neuroticism (Nagel 2018)	0.1	0.3	1.0	-0.9	-0.8	0.3	-0.4	-0.4	-0.9	0.3	-0.5	-0.6	-0.9	-0.3	0.7	0.3	-1.0	0.4	0.2	0.0	-0.2	-0.7
Coronary Artery Disease (CAD)	0.1	0.2	2.3	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-0.9	0.0	0.0	0.0	-1.5
Ulcerative Colitis	0.1	0.2	1.0	0.9	0.1	0.7	0.3	0.1	0.0	-0.1	0.2	-0.0	-0.1	-0.1	-0.5	-0.2	1.0	-0.6	0.0	0.0	-0.5	0.1
Blood Eosinophil Count	0.1	0.6	3.9	0.2	-0.0	-1.6	0.5	0.2	0.2	0.5	-0.7	0.5	0.0	2.0	1.1	1.0	-0.2	-1.1	0.0	0.6	-0.5	-0.2
Tanning	0.1	0.8	4.1	2.0	0.5	0.6	0.7	-0.1	0.2	-0.4	-0.2	-0.2	-0.0	0.3	-0.8	0.2	1.2	2.0	-0.2	0.8	-1.6	1.1
Number of treatments/medications taken	0.1	0.1	0.6	-0.8	0.2	-0.2	-0.4	0.7	-0.1	0.3	-0.5	0.4	-0.0	-0.2	-0.0	0.6	-0.2	0.0	0.5	0.1	0.1	0.1
Nervous feelings	0.1	0.2	0.9	0.7	0.2	-0.6	-0.1	0.3	0.9	0.7	-0.8	0.1	0.1	-0.2	0.9	0.5	0.1	-0.1	-0.3	-0.3	-0.3	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.2	1.3	1.1	0.3	0.7	-0.2	0.2	0.3	0.3	0.5	0.4	0.4	-0.3	-0.0	0.5	0.7	-0.1	-0.3	0.4	0.1	0.2
Pain all over the body in last month	0.1	0.2	1.2	-0.3	-0.1	0.8	0.1	-0.1	-0.4	0.5	0.3	-0.0	0.1	0.2	0.3	0.1	-0.3	-0.4	-1.1	0.0	-0.2	-0.1
Medication: Cholesterol lowering	0.1	0.2	0.7	-0.7	-0.2	0.2	-0.3	-0.3	-0.8	-0.3	-0.2	-0.2	-0.7	-0.3	-0.6	0.2	-0.3	-0.1	-0.5	0.3	0.2	0.3
Hair/balding pattern: Pattern 4	0.1	0.3	1.2	-0.7	-0.5	0.2	-0.7	-0.1	-0.8	0.2	-0.0	-0.2	-0.7	-0.1	0.0	-0.0	-0.7	1.1	0.8	0.2	1.0	0.2
Mother’s age at death	0.1	0.2	0.9	0.8	-0.1	-0.1	0.4	-0.3	0.9	-0.3	0.7	-0.1	-0.1	-0.3	0.4	0.1	0.5	-0.4	-0.2	-0.1	0.1	-0.1
Average weekly beer plus cider intake	0.1	0.2	1.2	-0.4	-0.1	1.1	-0.5	0.4	-0.8	-0.3	0.2	-0.1	0.2	-0.1	-0.7	-0.0	-0.5	0.2	-0.0	-0.3	0.2	-0.5
Major Depression (MDD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	0.5	4.4	-1.4	0.6	0.8	-0.5	0.2	-0.5	0.2	0.5	0.4	0.0	0.3	-0.3	0.5	-0.1	2.1	0.7	0.7	0.2	0.9

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Trait associations