Hub : Genes

FUZ

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2670	0.0540	4.6e-09	0.041	0.101	0.111	0.042	0.047	8.8e-06	2.9e-12	2.4e-13	6.5e-06	1.9e-06
2	GTEx	Muscle Skeletal	0.0856	0.0286	5.4e-05	0.062	NA	0.033	NA	-0.002	1.1e-06	NA	3.2e-04	NA	6.1e-01
3	GTEx	Testis	0.2380	0.0710	1.0e-04	0.057	NA	0.167	NA	0.150	1.5e-03	NA	6.8e-08	NA	3.4e-07
4	GTEx	Thyroid	0.0850	0.0330	1.3e-03	0.000	NA	0.009	NA	0.004	2.9e-01	NA	6.5e-02	NA	1.4e-01
5	TCGA	Brain Lower Grade Glioma	0.1074	0.0424	3.1e-06	0.051	0.052	0.057	NA	0.039	1.7e-06	1.4e-06	4.6e-07	NA	2.8e-05
6	TCGA	Ovarian Serous Cystadenocarcinoma	0.1460	0.0610	3.7e-04	0.075	0.041	0.027	NA	0.062	8.9e-06	9.2e-04	6.1e-03	NA	5.3e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.3	0.5	2.0	0.7	0.3	-0.0	0.5	0.2	1.4
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	0.2	-0.6	0.8	0.5	-0.4	0.5
Depressed Affect (Nagel 2018)	0.5	1.1	4.1	2.0	0.9	-0.7	-1.0	0.7	0.1
Depression (Nagel 2018)	0.8	1.2	6.2	2.5	0.4	-0.4	-0.5	0.2	0.1
Intelligence (Savage-Jansen 2018)	0.4	1.3	4.2	1.1	2.1	-1.0	-0.8	0.5	-0.5
Neuroticism (Nagel 2018)	1.4	3.3	6.8	2.6	2.1	-1.6	-2.2	0.9	-0.2
Schizophrenia (2018)	0.2	0.4	1.1	-0.1	-1.0	0.8	0.1	-0.7	-0.5
Schizophrenia vs Biploar Disorder	0.0	0.1	0.2	0.0	-0.4	0.5	0.1	0.0	0.0
Worry (Nagel 2018)	2.1	4.4	11.0	3.3	2.7	-1.7	-1.7	1.3	-0.9
Alzheimer’s Disease (in mother)	1.0	1.1	2.8	-0.8	-1.0	1.7	0.6	-0.1	1.4
Alzheimer’s Disease (in father)	1.1	1.2	4.0	-1.4	-1.0	0.2	0.1	-2.0	-0.6
Alzheimer’s Disease (including proxy)	0.5	0.7	1.4	-1.1	-0.5	1.2	-0.3	-0.9	0.6
Crohns Disease (2017)	0.2	0.4	1.4	-0.5	-0.5	0.3	-1.2	-0.2	-0.5
Irritable Bowel Disease (IBD)	0.1	0.3	1.3	-0.4	-0.2	0.5	-0.5	-0.1	-1.1
Ulcerative Colitis (UC)	0.2	0.4	1.5	-0.3	-0.2	1.2	0.3	-0.1	-0.8
Major Depression (MDD)	0.0	0.0	0.3	0.0	0.0	0.5	0.0	0.0	0.0
Reaction Time	0.4	0.7	2.2	-0.8	-0.2	-0.7	-0.8	-0.0	-1.5
Verbal and Numeric Reasoning (VNR)	0.9	2.3	5.0	1.6	1.8	-2.2	-1.4	0.5	-0.9
Breast Cancer	1.4	3.5	7.4	-2.7	0.5	-1.6	-1.4	-1.9	-2.2
Ovarian Cancer	0.6	0.7	1.3	0.9	1.1	-0.5	-1.0	0.3	-1.0
Prostate Cancer	0.3	0.4	1.4	0.6	0.1	-0.6	-0.6	0.2	-1.2
Age at First Birth	1.9	2.8	6.2	1.8	2.5	-1.0	-2.2	1.2	0.1
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.2	1.6	4.7	1.1	-0.3	0.2	0.4	2.2	1.8
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Crohns Disease (2012)	0.3	0.6	1.1	-0.6	-0.6	1.0	-0.6	-1.1	0.0
Mean Putamen Volume	0.2	0.3	0.6	-0.1	0.3	-0.5	-0.8	-0.7	0.4
Fasting Glucose	2.1	2.5	5.5	-2.3	-1.6	0.5	1.2	-2.2	-0.6
HbA1C	0.8	0.9	2.0	0.9	0.7	0.2	-0.9	-1.4	-1.2
HDL Cholesterol	1.0	1.6	3.0	-1.3	1.1	-1.4	-1.0	-0.8	-1.7
LDL Cholesterol	1.5	2.4	4.8	0.3	-1.2	1.1	1.6	2.0	2.2
Lupus	0.1	0.2	0.6	-0.8	0.3	0.0	0.5	-0.0	-0.4
Neuroticism (2016)	0.4	0.5	1.7	-0.6	0.5	-0.4	-1.3	-0.5	-0.8
Primary Biliary Cirrhosis	0.4	0.6	2.5	0.1	-0.5	0.5	-0.9	-0.3	-1.6
Rheumatoid Arthritis	0.5	0.7	1.6	0.6	0.5	-0.1	-1.2	1.3	0.5
Schizophrenia (2014)	0.5	1.0	2.2	-0.6	-1.4	0.3	0.8	-1.5	-0.9
Triglycerides	1.9	3.1	8.0	0.4	-1.4	1.7	1.5	1.8	2.8
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.7	1.0	2.4	0.9	0.8	-0.5	-1.5	0.7	-1.2
Blood Eosinophil Count	0.2	1.5	3.0	1.7	1.2	-0.2	-1.7	1.0	0.9
Blood Platelet Count	0.2	1.8	5.1	1.7	0.5	1.3	0.4	0.7	2.3
Blood Red Count	0.2	1.6	3.0	-1.4	-0.3	0.8	-1.5	1.3	1.7
Blood White Count	0.4	2.9	8.7	1.2	-0.8	2.0	1.4	0.6	3.0
Heel T-Score	0.2	1.9	7.0	1.1	2.6	-1.2	-0.1	1.4	-0.3
BMI	0.6	3.3	9.1	1.6	-1.1	1.3	2.1	0.5	3.0
Height	0.3	6.7	16.4	-2.3	-4.0	3.7	0.1	-1.7	1.2
Waist Hip Ratio (WHR)	0.0	0.1	0.5	-0.2	0.4	-0.2	0.3	-0.7	-0.0
Systolic Blood Pressure	0.3	1.5	4.5	-0.2	-0.7	1.3	1.6	0.0	2.1
Smoking Status	0.5	1.2	3.6	0.4	-1.1	1.9	-0.1	-1.3	0.8
Allergy or Eczema	0.5	1.3	4.8	0.3	1.0	-2.2	-1.0	0.4	-0.9
Cardiovascular Disease	0.2	0.6	1.6	0.3	-0.8	1.3	0.3	-0.9	0.3
Hypothyroidism (self reported)	1.2	2.7	6.1	-1.1	-0.9	-2.5	1.9	0.3	-2.1
Respiratory disease	0.1	0.3	0.5	-0.0	-0.6	-0.4	-0.5	0.7	0.6
Type 2 Diabetes (T2D) (2018)	2.3	4.4	9.9	2.6	1.3	-0.6	-1.2	3.1	2.4
Lung FEV1/FVC ratio	0.3	1.7	4.4	2.1	0.8	1.1	1.5	0.4	1.3
Lung FVC	0.3	1.3	2.9	-1.7	-0.5	1.5	1.1	-0.3	-1.0
Neuroticism	2.9	7.0	13.2	3.3	3.6	-1.9	-3.0	2.1	-0.8
Chronotype (morning person)	0.5	1.2	2.4	0.2	0.6	-1.3	-1.5	1.5	0.9
Hair Pigment	0.2	6.9	13.0	-0.2	-3.2	3.6	2.3	-1.0	3.4
Tanning	0.0	0.6	1.4	1.0	0.7	0.3	-1.2	0.6	0.4
Hand grip strength (left)	0.8	2.1	4.3	-0.8	-1.4	1.9	2.1	-0.7	1.2
Number of treatments/medications taken	0.2	0.4	1.1	-0.4	-0.2	-0.2	1.1	-0.7	0.6
Average weekly spirits intake	1.0	1.2	2.8	0.6	1.7	-1.6	-1.2	0.2	0.1
Sensitivity / hurt feelings	0.3	0.5	1.4	0.8	0.2	-0.2	-1.2	0.8	0.3
Frequency of depressed mood in last 2 weeks	0.4	0.5	2.7	1.6	-0.2	-0.1	0.4	0.0	0.3
Hearing difficulty/problems: Yes	1.6	2.5	5.1	-2.0	-1.1	1.6	2.3	-1.3	0.7
Relative age of first facial hair	1.4	2.9	11.5	1.4	1.3	-1.2	-3.4	-0.0	-1.2
Other serious medical condition/disability diagnosed by doctor	2.6	3.3	7.7	-2.2	-2.8	0.9	0.7	-2.1	-1.2
Ever used hormone-replacement therapy (HRT)	1.5	1.9	4.2	-1.7	0.7	-1.3	-1.4	-0.8	-2.0
Ever had hysterectomy (womb removed)	0.6	0.7	2.9	0.2	0.3	-1.7	0.1	1.0	0.0
Systolic blood pressure, automated reading	0.1	0.4	1.3	0.3	0.5	-0.2	1.1	-0.5	0.4
Eye problems/disorders: Diabetes related eye disease	1.8	2.0	4.6	1.3	1.7	-1.0	-2.1	0.9	-1.1
Angina	1.0	1.3	3.2	-1.8	-1.0	0.3	1.1	-1.3	-0.6
Medication for hormone replacement therapy	0.7	0.8	1.6	-1.3	-0.6	0.4	1.1	-1.0	-0.7
Vitamin and mineral supplements	0.9	1.2	3.1	0.4	0.8	0.8	0.8	1.4	1.8
Supplements: Zinc	1.5	1.6	6.6	0.3	1.0	-2.6	-0.6	0.3	-1.2
Medication: Co-codamol	1.2	1.4	5.3	-1.2	0.5	-2.3	-0.7	0.2	-0.9
Medication: Metformin	4.1	5.8	9.5	2.8	2.3	-2.0	-2.5	3.1	1.5
Diabetes (father)	0.5	0.6	1.3	0.4	0.8	-0.3	-0.9	1.1	0.9
Diabetes (mother)	0.8	1.0	4.0	0.5	-0.3	2.0	0.4	0.1	1.2
Severe depression (siblings)	0.2	0.3	0.9	-0.9	-0.3	-0.3	-0.1	-0.6	-0.4
Pack years adult smoking proportion	1.0	1.5	5.1	0.7	-1.0	0.8	0.1	1.4	2.2
Impedance of leg (right)	2.6	12.7	23.3	1.8	4.1	-3.6	-4.8	0.7	-4.4
Leg fat-free mass (left)	1.6	8.3	15.2	-1.1	-3.7	3.2	3.1	-0.5	3.9
Trunk fat percentage	1.1	4.5	9.1	3.0	2.3	-3.0	-0.8	1.7	0.3
Hand grip strength (right)	1.6	4.4	9.2	-2.0	-1.8	3.0	2.6	-1.5	0.9
Townsend deprivation index at recruitment	0.5	0.6	2.8	0.2	0.1	-0.5	-1.7	-0.1	-0.8
Current tobacco smoking	2.4	3.9	8.8	-0.5	-2.8	3.0	1.8	-1.3	1.2
Average weekly fortified wine intake	1.2	1.4	3.6	-0.9	-1.4	1.4	0.6	-0.2	1.9
Maternal smoking around birth	0.1	0.2	0.2	0.5	0.5	-0.4	-0.4	0.5	0.0
Fed-up feelings	0.6	1.0	2.8	0.6	0.8	-1.1	-0.6	-0.9	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.1	2.4	1.4	1.0	-0.9	-1.5	0.2	-0.9
Relative age voice broke	3.8	5.8	15.8	1.9	2.5	-2.5	-4.0	0.5	-1.7
Taking other prescription medications	0.3	0.4	1.9	-0.4	0.2	-1.4	0.5	0.4	-0.2
Age when periods started (menarche)	0.2	0.6	2.6	0.2	0.5	-0.3	-0.7	-1.6	-0.2
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	6.0	-2.4	0.0	0.3	0.6	0.2	-0.6
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.5	-0.7	0.9	1.2	0.2	0.4	-0.9
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	4.0	1.7	1.8	0.4	-1.1	2.0	0.3
Qualifications: CSEs or equivalent	1.7	2.2	6.2	-0.7	-1.1	2.2	0.3	-0.5	2.5
Serious illness, injury or assault to yourself	0.8	0.9	2.0	-0.8	-1.3	1.4	0.9	0.1	0.5
High blood pressure	0.3	0.7	1.7	1.3	-0.1	0.4	-0.6	0.9	1.1
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.9	0.3	1.0	-1.4	-0.7	0.7	0.2
Multivitamins +/- minerals	1.0	1.2	3.1	-0.8	-1.0	-0.3	0.1	-1.8	-1.6
Stomach or abdominal pain in last month	1.2	1.4	2.5	-1.6	-1.4	1.4	0.2	-1.1	1.1
Supplements: Glucosamine	1.1	1.4	3.3	1.0	1.8	-1.0	-1.8	-0.5	-0.2
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.0	-1.4	-1.1	0.6	1.1	-1.0	0.1
Medication: Atenolol	1.2	1.5	4.9	-1.7	-0.6	0.0	2.2	-0.8	-0.1
Medication: Levothyroxine sodium	1.1	1.9	6.4	-0.8	-0.7	-2.5	1.2	0.2	-1.6
Sitting height	1.2	8.7	20.3	-2.0	-3.7	4.5	2.4	-1.4	2.5
Chronic bronchitis/emphysema (father)	0.3	0.4	1.0	0.4	1.0	0.8	-0.5	0.2	-0.4
High blood pressure (mother)	0.3	0.4	1.0	-0.5	-0.1	-0.5	0.2	1.0	0.9
Body mass index (BMI)	0.5	2.1	5.6	1.1	-0.5	-0.2	2.3	0.2	2.4
Impedance of leg (left)	2.2	10.9	20.1	1.5	3.8	-3.3	-4.5	0.6	-4.1
Leg predicted mass (left)	1.6	8.2	15.1	-1.1	-3.7	3.1	3.1	-0.5	3.9
Trunk fat mass	0.4	1.7	4.2	2.1	0.7	-1.4	0.7	1.0	1.5
Waist circumference	0.5	1.8	5.5	1.8	-0.2	-0.6	1.0	0.4	2.3
Number of incorrect matches in round	0.2	0.4	1.3	0.1	0.6	-1.1	0.4	-0.1	-0.8
Past tobacco smoking	0.7	1.4	4.0	1.6	0.6	0.1	1.1	2.0	0.4
Alcohol usually taken with meals	1.4	2.3	4.5	1.8	1.6	-1.5	-1.2	2.1	0.3
Nervous feelings	0.7	1.4	4.5	2.1	1.7	-0.5	-0.6	0.5	-0.4
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	4.0	2.0	1.5	-1.8	-1.2	1.2	-0.8
Hearing difficulty/problems with background noise	0.1	0.2	0.7	0.2	0.3	0.4	0.7	-0.8	0.0
Hair/balding pattern: Pattern 2	0.3	0.3	1.2	-0.3	0.3	-0.1	1.1	0.4	-0.7
Had menopause	2.5	3.1	8.2	0.9	1.6	-2.9	-2.0	1.6	-0.7
Had other major operations	1.0	1.2	4.2	-2.1	-1.0	0.4	0.8	-0.7	-0.7
Forced vital capacity (FVC)	1.3	4.8	15.3	-2.2	-2.4	3.9	1.0	-1.4	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	3.9	-0.9	0.6	2.0	0.6	0.0	-1.1
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	3.8	0.4	0.7	1.1	-1.6	-0.1	-1.9
Qualifications: None of the above	0.5	1.1	2.9	0.1	0.6	-1.7	-1.2	-0.4	-1.5
Financial difficulties in last 2 years	0.7	1.0	2.2	-0.4	1.1	-1.4	-1.5	0.2	-0.6
Mouth/teeth dental problems	1.9	2.9	6.5	-0.7	-2.1	2.6	1.7	-1.1	1.4
Heart attack	0.4	0.5	1.3	1.2	0.5	0.3	-1.0	-0.1	0.6
Allergy	0.3	0.6	2.2	-0.0	-0.4	1.5	0.9	-0.5	-0.4
Pain all over the body in last month	0.2	0.2	0.5	-0.4	-0.7	-0.5	-0.4	0.2	0.1
Diabetes (self-reported)	2.0	3.1	4.9	1.8	1.7	-1.8	-2.2	1.8	1.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.0	0.3	1.0	0.7	-0.3	-0.0	0.3
Medication: Ramipril	1.8	2.3	3.3	1.7	1.4	-1.5	-1.8	1.8	-0.1
Medication: Simvastatin	1.0	1.5	4.0	2.0	0.9	0.1	-1.2	1.5	0.4
Fluid intelligence score	0.8	1.7	3.6	1.2	1.5	-1.9	-1.5	0.4	-0.6
Illnesses of siblings	1.1	1.5	2.8	1.7	1.3	-1.2	-1.6	0.2	-0.9
Neuroticism score	0.9	2.0	4.5	2.1	1.8	-0.4	-1.3	1.5	0.1
Weight	0.6	2.9	7.1	0.3	-1.9	1.1	2.3	-0.3	2.7
Impedance of arm (right)	3.2	14.9	26.3	1.8	3.9	-4.6	-5.1	1.5	-4.6
Arm fat percentage (right)	0.6	2.2	5.8	2.2	1.2	-2.4	0.3	0.8	0.7
Trunk fat-free mass	3.0	17.4	30.4	-3.0	-5.5	4.8	4.7	-2.0	4.1
Hip circumference	0.5	2.0	5.8	1.7	-0.9	0.2	1.6	0.5	2.4
Time employed in main current job	0.4	0.5	1.3	0.9	0.8	0.1	-1.2	0.1	-0.1
Alcohol intake versus 10 years previously	0.1	0.2	0.8	0.9	0.0	0.2	0.2	0.2	-0.3
Father’s age at death	1.9	2.5	5.3	2.2	2.3	-0.3	-1.1	1.9	0.2
Worrier / anxious feelings	0.3	0.6	1.5	0.5	1.2	-0.3	-1.0	0.3	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	1.0	0.2	0.2	0.3	0.2	-0.1	1.0
Falls in the last year	0.3	0.4	1.4	0.0	-0.8	-0.1	-1.2	-0.4	-0.7
Hair/balding pattern: Pattern 3	1.1	1.7	4.8	-2.2	-0.9	-0.3	0.7	-1.6	-1.2
Number of live births	0.2	0.3	1.0	-0.5	-0.5	1.0	0.0	0.5	0.4
Forced expiratory volume in 1-second (FEV1)	1.3	4.3	15.1	-1.6	-1.8	3.9	1.5	-1.4	0.4
Pulse rate	0.4	0.6	2.5	0.3	-0.0	0.6	0.5	-0.8	1.6
Happiness	1.0	1.2	3.0	-1.1	0.0	0.9	1.7	-1.4	-0.2
Noisy workplace	0.3	0.4	1.4	-1.2	-0.5	0.0	0.2	-0.3	-0.6
Qualifications: A levels/AS levels or equivalent	0.9	1.9	5.1	-0.7	-1.0	2.3	1.5	-0.2	1.6
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	3.3	1.0	0.9	-1.4	-1.8	0.6	1.0
Mouth/teeth dental problems: Dentures	1.6	2.6	4.8	1.1	2.2	-1.7	-2.0	1.2	-1.3
Asthma	0.2	0.4	1.4	0.0	-0.5	-0.7	-0.6	0.2	1.2
Medication: Ibuprofen (e.g. Nurofen)	4.2	5.4	11.8	-3.4	-1.9	1.6	2.6	-2.7	-0.6
Medication: Cholesterol lowering	0.5	0.7	2.1	1.4	0.6	-0.6	-1.2	0.4	0.3
Depression (self-reported)	1.6	1.9	5.5	1.3	2.3	-0.8	-0.3	1.6	-0.8
Medication: Lansoprazole	2.3	2.6	5.2	-0.1	2.3	-1.6	-2.2	0.1	-1.6
Prospective memory result	0.8	0.9	2.0	-0.5	-1.0	1.4	1.1	-0.7	0.7
Lung cancer (father)	0.6	0.7	1.6	0.6	-0.3	1.3	-0.5	1.0	1.0
Illnesses of mother	0.7	0.9	2.6	-0.3	0.3	1.2	-0.5	-0.8	-1.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.3	10.9	-1.7	-1.7	3.3	2.7	-1.3	-0.3
Pulse wave Arterial Stiffness index	1.6	1.8	4.2	-1.6	-2.0	0.4	1.6	-0.8	1.0
Impedance of arm (left)	3.1	14.6	23.9	2.2	4.0	-4.6	-4.9	1.9	-4.2
Arm fat mass (right)	0.4	1.6	4.5	1.5	-0.2	-0.6	1.5	0.5	2.1
Trunk predicted mass	3.0	17.4	29.8	-2.9	-5.5	4.7	4.7	-1.9	4.2
Standing height	0.6	5.6	13.2	-2.0	-3.6	3.5	0.9	-1.0	1.6
Length of working week for main job	1.0	1.1	2.5	1.0	0.1	-1.2	-1.2	1.6	-0.5
Exposure to tobacco smoke at home	1.9	2.2	3.0	1.5	1.6	-1.4	-1.5	0.8	-1.7
Breastfed as a baby	0.3	0.4	1.1	-0.0	0.5	-1.1	-0.8	0.4	-0.2
Tense / ‘highly strung’	1.3	2.1	5.5	2.4	1.4	0.4	-0.1	2.2	0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	2.3	1.1	1.5	-0.5	-0.4	0.3	0.4
Hair/balding pattern: Pattern 4	0.5	1.2	2.9	1.5	1.0	-0.7	-1.7	0.3	-0.6
Birth weight of first child	0.5	0.9	3.0	-0.3	1.7	-0.9	-0.5	0.4	-1.1
Peak expiratory flow (PEF)	1.4	3.4	7.3	-0.8	-2.1	2.7	2.0	-1.4	1.5
Pulse wave reflection index	2.6	3.2	8.1	-1.7	-2.8	1.6	1.9	-0.8	1.2
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.6	0.0	0.8	-0.6	-0.1	0.2	-0.6
Loud music exposure frequency	1.4	1.5	5.2	1.3	1.2	-0.4	-0.8	2.3	0.2
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	4.3	-0.0	-1.4	2.1	1.6	0.2	2.0
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	3.0	0.7	0.6	-1.1	-1.7	1.0	-0.5
Blood clot in the leg (DVT)	1.5	2.0	4.4	-1.2	-1.5	2.1	1.8	-0.4	0.7
Medication: Paracetamol	0.9	1.6	5.8	-1.0	-0.5	0.5	2.4	-1.4	-0.5
Headache pain in last month	2.0	3.4	6.5	-1.2	-2.5	1.5	2.5	-0.8	1.9
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.4	-1.2	0.1	-0.3	0.5	-0.3	0.0
Glaucoma (self-reported)	0.6	0.7	1.3	0.4	-1.2	-0.6	0.7	-1.2	-0.7
Gout (self-reported)	0.4	0.6	0.9	-1.0	0.7	0.7	-0.8	-0.9	-0.6
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	4.7	-0.9	-0.8	-2.2	1.5	0.4	-1.6
Medication: Amlodipine	0.5	0.7	2.1	-0.4	0.1	0.7	0.0	1.4	1.2
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.4	0.2	-0.2	-0.6	-0.4	-0.6	0.1
Birth weight	0.8	1.6	5.7	-0.4	-1.0	1.7	2.4	-0.1	0.4
Chronic bronchitis/emphysema (mother)	1.6	1.9	3.5	1.8	1.9	-1.2	0.2	1.8	-0.0
High blood pressure (siblings)	0.9	1.2	3.5	-0.5	-1.1	0.9	1.1	0.6	1.9
Forced vital capacity (FVC), Best measure	1.3	4.6	13.3	-2.0	-2.0	3.6	2.1	-1.4	-0.2
Body fat percentage	1.1	4.4	9.5	3.0	2.3	-3.1	-0.6	1.4	0.5
Leg fat percentage (right)	1.1	4.2	8.9	2.9	2.4	-3.0	-0.6	1.1	0.4
Arm fat-free mass (right)	2.3	11.8	18.5	-1.7	-4.1	4.1	3.9	-1.1	4.3
Exposure to tobacco smoke outside home	1.0	1.3	2.7	0.9	1.1	-1.0	-1.6	1.3	0.6
Comparative body size at age 10	1.1	3.1	8.1	2.6	1.0	-1.1	-0.4	2.9	1.2
Number of full brothers	1.0	1.2	2.8	-1.5	-1.3	1.7	0.7	-0.4	0.2
Worry too long after embarrassment	1.8	3.0	7.0	1.4	2.6	-1.9	-1.7	1.6	-0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.2	0.7	0.7	-0.3	0.5	0.9	1.1
Wheeze or whistling in the chest in last year	0.4	0.6	2.1	-1.4	-0.8	0.3	-0.5	-0.8	0.3
Number of children fathered	0.1	0.1	0.4	-0.2	0.4	0.2	0.1	0.2	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	3.6	-1.9	-0.2	0.9	0.8	-0.9	-0.6
Age at first live birth	1.5	2.7	9.5	3.1	0.7	1.8	-0.7	0.8	1.2
Pulse wave peak to peak time	1.4	1.6	3.9	1.3	2.0	-0.3	-1.4	0.7	-1.1
Health satisfaction	0.1	0.2	0.7	0.2	0.4	-0.2	-0.3	0.9	0.2
Shortness of breath walking on level ground	0.3	0.4	0.8	0.3	0.5	-0.6	-0.7	-0.9	-0.5
Qualifications: College or University degree	0.1	0.3	0.8	0.7	0.9	0.1	-0.4	-0.1	-0.3
Eye problems/disorders: None of the above	0.4	0.5	1.2	-1.1	-0.3	0.7	0.2	0.0	1.0
Mouth/teeth dental problems: Loose teeth	1.3	1.5	4.0	0.3	2.0	-1.6	-0.7	1.1	-0.8
Emphysema/chronic bronchitis	0.2	0.3	0.5	-0.5	-0.7	0.6	-0.4	-0.3	-0.5
Medication for pain relief, constipation, heartburn	2.5	4.2	9.4	1.9	1.9	-2.6	-3.1	1.0	-1.1
Neck or shoulder pain in last month	0.6	0.9	2.1	-1.0	-0.9	0.8	1.5	0.1	1.0
Medication: Blood pressure	0.2	0.3	1.0	0.6	-0.3	1.0	-0.3	0.7	-0.2
Angina (self-reported)	0.9	1.2	2.2	-1.5	-1.0	0.2	1.2	-1.4	-0.8
Migraine (self-reported)	5.6	6.9	20.5	-1.6	-2.5	2.7	4.5	-0.3	2.2
Medication: Ibuprofen	4.4	5.2	9.9	-3.1	-2.0	2.0	2.6	-2.6	-0.1
Medication: Allopurinol	0.5	0.6	2.9	-0.2	-0.6	1.7	-0.4	0.2	0.5
Medication: Omeprazole	0.2	0.2	0.5	-0.6	-0.7	0.0	0.5	0.3	-0.3
Medication: Seretide 50 evohaler	0.5	0.5	1.2	1.0	-0.3	-0.9	-1.1	-0.2	0.2
Mean time to correctly identify matches	1.4	2.7	5.4	-0.1	0.6	-2.3	-2.2	0.5	-2.3
Heart disease (mother)	0.6	0.7	2.4	-0.7	-0.4	-1.6	-0.1	-1.2	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	0.7	0.4	0.4	-0.2	-0.7	-0.1
Whole body fat mass	0.4	1.7	3.7	1.9	0.5	-1.2	0.9	0.9	1.8
Leg fat mass (right)	0.4	1.7	4.0	2.0	0.5	-1.0	0.7	0.9	1.9
Arm predicted mass (right)	2.5	12.8	20.6	-1.5	-4.3	4.3	4.0	-1.0	4.5
Pulse rate, automated reading	0.1	0.4	0.9	0.8	0.9	-0.2	0.4	-0.9	-0.2
Alcohol intake frequency.	0.8	1.8	4.1	-1.0	-2.0	1.0	1.9	-0.9	0.7
Comparative height size at age 10	0.7	3.8	9.9	-2.5	-3.1	2.2	0.5	-1.0	0.6
Number of full sisters	0.4	0.5	1.4	-0.3	-1.2	0.3	-0.2	0.3	1.0
Suffer from ‘nerves’	1.5	2.3	6.2	2.5	1.6	-0.5	-1.8	1.2	-0.4
Overall health rating	1.4	3.1	6.6	2.1	1.1	-2.6	0.0	2.1	1.4
Chest pain or discomfort	0.2	0.2	0.7	-0.8	-0.4	-0.1	0.6	0.5	0.0
Had major operations	0.0	0.0	0.1	-0.1	-0.1	-0.2	0.3	0.4	0.0
Age at last live birth	1.9	2.7	9.9	3.1	1.1	1.4	-1.5	0.9	0.6
Family relationship satisfaction	0.6	0.8	3.8	2.0	0.3	-0.2	0.7	-0.3	-0.2
Leg pain on walking	0.9	1.1	2.0	-1.1	-1.2	0.7	1.4	-0.4	1.1
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.7	-1.6	-1.4	0.6	1.1	0.4	0.8
Commuting to job workplace: Car/motor vehicle	0.7	0.9	2.5	-0.5	-0.3	0.8	1.3	-0.3	1.6
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	-0.1	0.4	0.2	0.4	0.5	0.2
Medication: Aspirin	1.0	1.3	4.0	0.6	0.3	1.1	0.1	1.4	2.0
Supplements: Vitamin C	1.2	1.4	3.8	-0.9	0.2	-1.3	-1.3	-0.7	-1.9
Knee pain experienced in last month	0.3	0.4	0.8	0.3	-0.1	-0.6	0.7	0.9	0.7
Hypertension (Self-reported)	0.2	0.5	1.4	1.2	0.1	0.0	-0.8	0.8	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.8	-0.1	0.4	-0.4	-0.1	-0.6	-0.9
Illnesses of father: Heart disease	0.9	1.3	3.6	-1.9	-0.8	-0.9	-0.1	-1.6	-0.7
Illnesses of siblings: Diabetes	0.1	0.2	0.3	-0.2	0.5	-0.6	-0.5	-0.1	-0.3
Smoking status: Previous	1.0	1.5	2.9	-1.3	0.4	-1.1	-1.5	-1.7	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.2	5.2	-0.4	-1.9	2.3	1.4	-0.4	1.2
Whole body fat-free mass	2.5	14.4	25.0	-2.3	-5.0	4.3	4.2	-1.4	4.2
Leg fat-free mass (right)	1.8	9.9	16.2	-1.5	-4.0	3.5	3.5	-0.8	4.0
Arm fat percentage (left)	0.7	3.0	7.0	2.6	1.4	-2.5	0.4	1.3	1.0
Average weekly red wine intake	0.9	1.4	3.2	0.2	1.8	-1.1	-1.8	0.8	-0.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.2	0.4	-0.8	0.1	0.4	1.1	0.9
Mood swings	1.0	1.8	5.6	2.4	0.9	0.4	-1.3	1.3	0.9
Loneliness, isolation	0.6	0.9	2.3	0.8	-1.5	1.2	0.9	0.3	0.4
Long-standing illness, disability or infirmity	0.2	0.4	1.5	0.5	1.2	-0.3	-0.5	0.2	-0.0
Ever had bowel cancer screening	1.0	1.1	2.6	-0.1	0.7	-1.3	-1.6	0.6	-1.3
Diabetes diagnosed by doctor	1.4	2.3	4.1	1.4	1.0	-1.0	-2.0	1.9	1.6
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.3	-0.6	-0.8	1.1	-0.4	-0.5	1.0
Friendships satisfaction	0.3	0.3	1.1	-0.2	-0.5	1.1	0.6	0.4	0.3
Qualifications: nursing, teaching	0.9	1.5	3.5	0.2	-0.2	1.3	0.7	1.7	1.9
Commuting to job workplace: Walk	1.0	1.1	3.8	0.2	0.1	-1.9	-0.8	0.2	-1.3
Eye problems/disorders: Cataract	0.1	0.1	0.3	-0.4	0.1	0.4	0.4	-0.6	0.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.3	-1.5	-0.1	-0.7	0.8	-0.5	-1.1
Medication for cholesterol	0.3	0.5	1.3	0.5	0.2	-0.8	-0.8	0.2	-1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	4.5	-0.3	0.6	-1.1	-0.1	-0.2	-2.1
Back pain experienced in last month	1.0	1.5	3.0	-1.7	-1.7	0.1	0.8	-1.4	0.8
Mineral and other dietary supplements	0.4	0.5	1.2	0.1	-0.6	1.1	-0.0	0.7	0.9
Breast cancer (self-reported)	1.0	1.2	2.2	-0.5	-1.1	0.7	1.4	1.5	1.1
Asthma (self-reported)	0.2	0.4	1.0	-0.1	-0.3	-0.8	-0.7	0.2	1.0
Osteoporosis (self-reported)	0.7	0.9	2.0	-1.4	-0.0	-0.6	-1.4	0.2	-1.1
Osteoarthritis (self-reported)	1.1	1.5	3.5	-0.9	-1.0	-0.6	1.9	-1.6	0.7
Medication: Aspirin	0.7	0.9	2.2	0.6	0.7	1.0	-0.4	1.1	1.5
Medication: Gliclazide	0.7	0.8	2.1	0.1	1.1	-0.6	-1.4	0.6	-0.8
Illnesses of father: None of the above (group 1)	1.9	2.3	6.6	2.6	0.9	-0.7	-0.6	2.3	0.4
Smoking status: Current	1.9	3.0	6.9	-0.3	-2.6	2.4	1.5	-1.3	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.5	-0.6	0.3	1.9	1.1	0.3	1.1
Whole body water mass	2.5	14.4	24.9	-2.3	-5.0	4.3	4.2	-1.4	4.2
Leg predicted mass (right)	1.9	10.1	16.6	-1.5	-4.1	3.5	3.5	-0.7	4.0
Arm fat mass (left)	0.5	2.0	6.1	1.5	-0.5	-0.3	1.7	0.6	2.5
Number of self-reported non-cancer illnesses	0.4	0.7	1.9	-1.4	-1.1	-0.2	0.6	-0.2	0.9
Average weekly champagne plus white wine intake	0.7	1.0	2.6	1.1	0.6	-0.6	-1.6	0.7	-0.9
Miserableness	0.2	0.4	1.1	0.3	-0.5	1.1	-0.2	0.3	0.7
Guilty feelings	1.1	1.6	3.5	-0.8	1.4	-1.0	-1.6	-0.4	-1.9
Wears glasses or contact lenses	1.5	1.7	6.4	1.0	0.9	-2.5	-1.2	-0.2	-0.8
Ever taken oral contraceptive pill	0.3	0.4	1.6	0.1	0.1	-0.4	-1.3	0.2	-0.6
Hearing aid user	0.2	0.2	1.1	0.1	-0.1	-0.1	1.1	0.4	-0.3
Mother’s age at death	0.7	0.9	2.1	0.1	1.4	-0.6	-1.5	1.1	0.1
Financial situation satisfaction	0.8	0.9	2.6	0.8	1.6	-1.2	0.2	1.0	-0.1
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.1	-1.1	-1.1	1.5	0.5	-0.6	0.5
Commuting to job workplace: Public transport	1.2	1.4	3.8	0.7	1.5	-0.2	-1.9	0.2	-1.4
Eye problems/disorders: Glaucoma	0.6	0.7	1.2	0.8	-0.7	-1.0	0.6	-0.7	-1.1
Medication: Blood pressure	0.3	0.6	3.3	-0.0	0.3	0.1	-0.4	0.2	1.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.8	-0.6	-0.7	-0.1	0.9	-0.3	0.6
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.9	-0.6	-0.2	-0.5	0.8	-1.3	-1.7
High cholesterol (Self-reported)	0.7	1.2	3.8	1.9	0.5	-0.1	-1.7	0.3	0.3
Medication: Bendroflumethiazide	0.6	0.8	2.2	0.3	0.8	-0.8	-1.0	1.5	0.6
Medication: Paracetamol	1.4	2.2	4.6	-1.7	-1.1	1.1	2.1	-1.8	-0.6
Medication: Lisinopril	0.2	0.3	1.1	-0.0	-0.1	-0.1	-0.5	0.4	1.1
Medication: Atorvastatin	0.6	0.7	1.2	-0.9	-1.0	-0.3	0.1	-1.0	1.1
Illnesses of father: High blood pressure	2.0	2.5	5.6	-1.6	-2.4	1.8	1.1	-0.3	1.5
Alcohol drinker status: Never	0.3	0.4	0.8	-0.8	-0.4	-0.2	0.7	-0.9	-0.1
Ever smoked	0.6	1.1	1.7	-1.1	-1.1	1.1	-1.1	-1.3	0.5
Basal metabolic rate	2.0	10.9	18.4	-1.7	-4.3	3.6	3.9	-1.1	3.9
Leg fat percentage (left)	1.0	3.7	7.9	2.8	2.3	-2.8	-0.2	1.0	0.7
Arm fat-free mass (left)	2.3	11.7	18.2	-1.7	-4.2	3.8	3.9	-1.4	4.3
Number of operations (self-reported)	0.4	0.6	1.9	-1.4	-1.2	-0.3	-0.3	0.1	0.3
Average weekly beer plus cider intake	0.4	0.6	1.1	-0.7	0.4	-0.9	-0.5	-1.1	-0.6
Irritability	1.4	2.4	6.4	2.5	1.1	-0.0	-1.0	1.8	1.6
Risk taking	0.3	0.5	0.8	-0.9	0.7	-0.6	-0.9	-0.5	-0.5
Ever had prostate specific antigen (PSA) test	1.8	2.1	5.4	-1.7	-2.3	1.4	1.1	-0.5	0.9
Fractured/broken bones in last 5 years	0.2	0.3	0.8	-0.4	-0.1	-0.7	-0.9	0.0	0.5
Age started oral contraceptive pill	0.5	0.7	1.5	-0.0	-0.2	1.1	-1.0	0.5	1.2
Diastolic blood pressure, automated reading	0.4	1.1	3.9	-0.1	-0.5	0.7	2.0	-0.8	1.2
Ever depressed for a whole week	0.4	0.4	1.3	0.6	0.7	1.1	-0.3	0.1	-0.7
Unable to work because of sickness or disability	0.4	0.5	1.6	1.3	-0.1	-0.9	-0.6	0.2	-0.4
Commuting to job workplace: Cycle	1.4	1.6	2.8	1.3	1.1	-1.7	-1.5	0.8	-1.1
Myopia	0.7	1.1	3.0	1.0	0.6	-0.7	-1.7	0.9	0.7
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.9	-1.0	-0.0	-0.2	0.9	-0.6	-0.8
Cholesterol lowering medication	0.9	1.3	5.6	0.7	-0.1	0.3	0.1	1.2	2.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	0.2	0.4	-0.6	-0.5	0.3	-0.6
Pain experienced in last month	0.2	0.4	0.9	0.9	0.9	0.1	-0.6	0.1	-0.7
Supplements: Calcium	1.1	1.2	2.5	-1.6	-1.0	-1.2	-0.4	-1.3	-0.4
Basal cell carcinoma (self-reported)	2.0	2.4	6.2	2.1	1.2	-2.5	-0.1	1.5	-0.3
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.4	0.9	0.0	0.4	-1.2	-0.2	0.7
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	4.6	-0.8	-1.4	2.1	1.4	-0.0	0.8
Heart disease (siblings)	0.4	0.5	2.3	-1.5	-0.7	0.2	-0.3	-0.2	-0.1
Alcohol drinker status: Previous	0.5	0.5	1.6	0.1	-1.3	0.8	0.4	0.0	0.8
Pack years of smoking	0.6	0.9	3.3	0.4	-0.6	0.1	-0.0	1.2	1.8
Impedance of whole body	3.3	17.0	30.6	2.5	4.6	-4.5	-5.5	1.8	-4.4
Leg fat mass (left)	0.5	1.8	4.6	2.0	0.4	-0.8	0.9	0.8	2.1
Arm predicted mass (left)	2.5	12.6	20.0	-1.6	-4.3	4.0	4.1	-1.3	4.5