TWAS hub - FUZ

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2670	0.0540	4.6e-09	0.041	0.101	0.111	0.042	0.047	8.8e-06	2.9e-12	2.4e-13	6.5e-06	1.9e-06
2	GTEx	Muscle Skeletal	0.0856	0.0286	5.4e-05	0.062	NA	0.033	NA	-0.002	1.1e-06	NA	3.2e-04	NA	6.1e-01
3	GTEx	Testis	0.2380	0.0710	1.0e-04	0.057	NA	0.167	NA	0.150	1.5e-03	NA	6.8e-08	NA	3.4e-07
4	GTEx	Thyroid	0.0850	0.0330	1.3e-03	0.000	NA	0.009	NA	0.004	2.9e-01	NA	6.5e-02	NA	1.4e-01
5	TCGA	Brain Lower Grade Glioma	0.1074	0.0424	3.1e-06	0.051	0.052	0.057	NA	0.039	1.7e-06	1.4e-06	4.6e-07	NA	2.8e-05
6	TCGA	Ovarian Serous Cystadenocarcinoma	0.1460	0.0610	3.7e-04	0.075	0.041	0.027	NA	0.062	8.9e-06	9.2e-04	6.1e-03	NA	5.3e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Migraine (self-reported)	5.6	6.9	20.5	-1.6	-2.5	2.7	4.5	-0.3	2.2
Medication: Ibuprofen	4.4	5.2	9.9	-3.1	-2.0	2.0	2.6	-2.6	-0.1
Medication: Ibuprofen (e.g. Nurofen)	4.2	5.4	11.8	-3.4	-1.9	1.6	2.6	-2.7	-0.6
Medication: Metformin	4.1	5.8	9.5	2.8	2.3	-2.0	-2.5	3.1	1.5
Relative age voice broke	3.8	5.8	15.8	1.9	2.5	-2.5	-4.0	0.5	-1.7
Impedance of whole body	3.3	17.0	30.6	2.5	4.6	-4.5	-5.5	1.8	-4.4
Impedance of arm (right)	3.2	14.9	26.3	1.8	3.9	-4.6	-5.1	1.5	-4.6
Impedance of arm (left)	3.1	14.6	23.9	2.2	4.0	-4.6	-4.9	1.9	-4.2
Trunk fat-free mass	3.0	17.4	30.4	-3.0	-5.5	4.8	4.7	-2.0	4.1
Trunk predicted mass	3.0	17.4	29.8	-2.9	-5.5	4.7	4.7	-1.9	4.2
Neuroticism	2.9	7.0	13.2	3.3	3.6	-1.9	-3.0	2.1	-0.8
Other serious medical condition/disability diagnosed by doctor	2.6	3.3	7.7	-2.2	-2.8	0.9	0.7	-2.1	-1.2
Impedance of leg (right)	2.6	12.7	23.3	1.8	4.1	-3.6	-4.8	0.7	-4.4
Pulse wave reflection index	2.6	3.2	8.1	-1.7	-2.8	1.6	1.9	-0.8	1.2
Had menopause	2.5	3.1	8.2	0.9	1.6	-2.9	-2.0	1.6	-0.7
Medication for pain relief, constipation, heartburn	2.5	4.2	9.4	1.9	1.9	-2.6	-3.1	1.0	-1.1
Arm predicted mass (right)	2.5	12.8	20.6	-1.5	-4.3	4.3	4.0	-1.0	4.5
Whole body fat-free mass	2.5	14.4	25.0	-2.3	-5.0	4.3	4.2	-1.4	4.2
Whole body water mass	2.5	14.4	24.9	-2.3	-5.0	4.3	4.2	-1.4	4.2
Arm predicted mass (left)	2.5	12.6	20.0	-1.6	-4.3	4.0	4.1	-1.3	4.5
Current tobacco smoking	2.4	3.9	8.8	-0.5	-2.8	3.0	1.8	-1.3	1.2
Type 2 Diabetes (T2D) (2018)	2.3	4.4	9.9	2.6	1.3	-0.6	-1.2	3.1	2.4
Medication: Lansoprazole	2.3	2.6	5.2	-0.1	2.3	-1.6	-2.2	0.1	-1.6
Arm fat-free mass (right)	2.3	11.8	18.5	-1.7	-4.1	4.1	3.9	-1.1	4.3
Arm fat-free mass (left)	2.3	11.7	18.2	-1.7	-4.2	3.8	3.9	-1.4	4.3
Impedance of leg (left)	2.2	10.9	20.1	1.5	3.8	-3.3	-4.5	0.6	-4.1
Worry (Nagel 2018)	2.1	4.4	11.0	3.3	2.7	-1.7	-1.7	1.3	-0.9
Fasting Glucose	2.1	2.5	5.5	-2.3	-1.6	0.5	1.2	-2.2	-0.6
Diabetes (self-reported)	2.0	3.1	4.9	1.8	1.7	-1.8	-2.2	1.8	1.2
Headache pain in last month	2.0	3.4	6.5	-1.2	-2.5	1.5	2.5	-0.8	1.9
Illnesses of father: High blood pressure	2.0	2.5	5.6	-1.6	-2.4	1.8	1.1	-0.3	1.5
Basal metabolic rate	2.0	10.9	18.4	-1.7	-4.3	3.6	3.9	-1.1	3.9
Basal cell carcinoma (self-reported)	2.0	2.4	6.2	2.1	1.2	-2.5	-0.1	1.5	-0.3
Age at First Birth	1.9	2.8	6.2	1.8	2.5	-1.0	-2.2	1.2	0.1
Triglycerides	1.9	3.1	8.0	0.4	-1.4	1.7	1.5	1.8	2.8
Mouth/teeth dental problems	1.9	2.9	6.5	-0.7	-2.1	2.6	1.7	-1.1	1.4
Father’s age at death	1.9	2.5	5.3	2.2	2.3	-0.3	-1.1	1.9	0.2
Exposure to tobacco smoke at home	1.9	2.2	3.0	1.5	1.6	-1.4	-1.5	0.8	-1.7
Age at last live birth	1.9	2.7	9.9	3.1	1.1	1.4	-1.5	0.9	0.6
Illnesses of father: None of the above (group 1)	1.9	2.3	6.6	2.6	0.9	-0.7	-0.6	2.3	0.4
Smoking status: Current	1.9	3.0	6.9	-0.3	-2.6	2.4	1.5	-1.3	1.0
Leg predicted mass (right)	1.9	10.1	16.6	-1.5	-4.1	3.5	3.5	-0.7	4.0
Eye problems/disorders: Diabetes related eye disease	1.8	2.0	4.6	1.3	1.7	-1.0	-2.1	0.9	-1.1
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	4.0	1.7	1.8	0.4	-1.1	2.0	0.3
Medication: Ramipril	1.8	2.3	3.3	1.7	1.4	-1.5	-1.8	1.8	-0.1
Worry too long after embarrassment	1.8	3.0	7.0	1.4	2.6	-1.9	-1.7	1.6	-0.3
Leg fat-free mass (right)	1.8	9.9	16.2	-1.5	-4.0	3.5	3.5	-0.8	4.0
Ever had prostate specific antigen (PSA) test	1.8	2.1	5.4	-1.7	-2.3	1.4	1.1	-0.5	0.9
Qualifications: CSEs or equivalent	1.7	2.2	6.2	-0.7	-1.1	2.2	0.3	-0.5	2.5
Hearing difficulty/problems: Yes	1.6	2.5	5.1	-2.0	-1.1	1.6	2.3	-1.3	0.7
Leg fat-free mass (left)	1.6	8.3	15.2	-1.1	-3.7	3.2	3.1	-0.5	3.9
Hand grip strength (right)	1.6	4.4	9.2	-2.0	-1.8	3.0	2.6	-1.5	0.9
Leg predicted mass (left)	1.6	8.2	15.1	-1.1	-3.7	3.1	3.1	-0.5	3.9
Mouth/teeth dental problems: Dentures	1.6	2.6	4.8	1.1	2.2	-1.7	-2.0	1.2	-1.3
Depression (self-reported)	1.6	1.9	5.5	1.3	2.3	-0.8	-0.3	1.6	-0.8
Pulse wave Arterial Stiffness index	1.6	1.8	4.2	-1.6	-2.0	0.4	1.6	-0.8	1.0
Chronic bronchitis/emphysema (mother)	1.6	1.9	3.5	1.8	1.9	-1.2	0.2	1.8	-0.0
LDL Cholesterol	1.5	2.4	4.8	0.3	-1.2	1.1	1.6	2.0	2.2
Ever used hormone-replacement therapy (HRT)	1.5	1.9	4.2	-1.7	0.7	-1.3	-1.4	-0.8	-2.0
Supplements: Zinc	1.5	1.6	6.6	0.3	1.0	-2.6	-0.6	0.3	-1.2
Blood clot in the leg (DVT)	1.5	2.0	4.4	-1.2	-1.5	2.1	1.8	-0.4	0.7
Age at first live birth	1.5	2.7	9.5	3.1	0.7	1.8	-0.7	0.8	1.2
Suffer from ‘nerves’	1.5	2.3	6.2	2.5	1.6	-0.5	-1.8	1.2	-0.4
Wears glasses or contact lenses	1.5	1.7	6.4	1.0	0.9	-2.5	-1.2	-0.2	-0.8
Neuroticism (Nagel 2018)	1.4	3.3	6.8	2.6	2.1	-1.6	-2.2	0.9	-0.2
Breast Cancer	1.4	3.5	7.4	-2.7	0.5	-1.6	-1.4	-1.9	-2.2
Relative age of first facial hair	1.4	2.9	11.5	1.4	1.3	-1.2	-3.4	-0.0	-1.2
Alcohol usually taken with meals	1.4	2.3	4.5	1.8	1.6	-1.5	-1.2	2.1	0.3
Frequency of tenseness / restlessness in last 2 weeks	1.4	2.2	4.0	2.0	1.5	-1.8	-1.2	1.2	-0.8
Peak expiratory flow (PEF)	1.4	3.4	7.3	-0.8	-2.1	2.7	2.0	-1.4	1.5
Loud music exposure frequency	1.4	1.5	5.2	1.3	1.2	-0.4	-0.8	2.3	0.2
Pulse wave peak to peak time	1.4	1.6	3.9	1.3	2.0	-0.3	-1.4	0.7	-1.1
Mean time to correctly identify matches	1.4	2.7	5.4	-0.1	0.6	-2.3	-2.2	0.5	-2.3
Overall health rating	1.4	3.1	6.6	2.1	1.1	-2.6	0.0	2.1	1.4
Diabetes diagnosed by doctor	1.4	2.3	4.1	1.4	1.0	-1.0	-2.0	1.9	1.6
Medication: Paracetamol	1.4	2.2	4.6	-1.7	-1.1	1.1	2.1	-1.8	-0.6
Irritability	1.4	2.4	6.4	2.5	1.1	-0.0	-1.0	1.8	1.6
Commuting to job workplace: Cycle	1.4	1.6	2.8	1.3	1.1	-1.7	-1.5	0.8	-1.1
Forced vital capacity (FVC)	1.3	4.8	15.3	-2.2	-2.4	3.9	1.0	-1.4	0.3
Forced expiratory volume in 1-second (FEV1)	1.3	4.3	15.1	-1.6	-1.8	3.9	1.5	-1.4	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.3	10.9	-1.7	-1.7	3.3	2.7	-1.3	-0.3
Tense / ‘highly strung’	1.3	2.1	5.5	2.4	1.4	0.4	-0.1	2.2	0.1
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	4.3	-0.0	-1.4	2.1	1.6	0.2	2.0
Forced vital capacity (FVC), Best measure	1.3	4.6	13.3	-2.0	-2.0	3.6	2.1	-1.4	-0.2
Mouth/teeth dental problems: Loose teeth	1.3	1.5	4.0	0.3	2.0	-1.6	-0.7	1.1	-0.8
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	4.6	-0.8	-1.4	2.1	1.4	-0.0	0.8
Body Mass Index (BMI) (2010)	1.2	1.6	4.7	1.1	-0.3	0.2	0.4	2.2	1.8
Hypothyroidism (self reported)	1.2	2.7	6.1	-1.1	-0.9	-2.5	1.9	0.3	-2.1
Medication: Co-codamol	1.2	1.4	5.3	-1.2	0.5	-2.3	-0.7	0.2	-0.9
Average weekly fortified wine intake	1.2	1.4	3.6	-0.9	-1.4	1.4	0.6	-0.2	1.9
Stomach or abdominal pain in last month	1.2	1.4	2.5	-1.6	-1.4	1.4	0.2	-1.1	1.1
Medication: Atenolol	1.2	1.5	4.9	-1.7	-0.6	0.0	2.2	-0.8	-0.1
Sitting height	1.2	8.7	20.3	-2.0	-3.7	4.5	2.4	-1.4	2.5
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	3.3	1.0	0.9	-1.4	-1.8	0.6	1.0
Supplements: Vitamin C	1.2	1.4	3.8	-0.9	0.2	-1.3	-1.3	-0.7	-1.9
Commuting to job workplace: Public transport	1.2	1.4	3.8	0.7	1.5	-0.2	-1.9	0.2	-1.4
Alzheimer’s Disease (in father)	1.1	1.2	4.0	-1.4	-1.0	0.2	0.1	-2.0	-0.6
Trunk fat percentage	1.1	4.5	9.1	3.0	2.3	-3.0	-0.8	1.7	0.3
Supplements: Glucosamine	1.1	1.4	3.3	1.0	1.8	-1.0	-1.8	-0.5	-0.2
Medication: Levothyroxine sodium	1.1	1.9	6.4	-0.8	-0.7	-2.5	1.2	0.2	-1.6
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	3.8	0.4	0.7	1.1	-1.6	-0.1	-1.9
Illnesses of siblings	1.1	1.5	2.8	1.7	1.3	-1.2	-1.6	0.2	-0.9
Hair/balding pattern: Pattern 3	1.1	1.7	4.8	-2.2	-0.9	-0.3	0.7	-1.6	-1.2
Body fat percentage	1.1	4.4	9.5	3.0	2.3	-3.1	-0.6	1.4	0.5
Leg fat percentage (right)	1.1	4.2	8.9	2.9	2.4	-3.0	-0.6	1.1	0.4
Comparative body size at age 10	1.1	3.1	8.1	2.6	1.0	-1.1	-0.4	2.9	1.2
Osteoarthritis (self-reported)	1.1	1.5	3.5	-0.9	-1.0	-0.6	1.9	-1.6	0.7
Guilty feelings	1.1	1.6	3.5	-0.8	1.4	-1.0	-1.6	-0.4	-1.9
Supplements: Calcium	1.1	1.2	2.5	-1.6	-1.0	-1.2	-0.4	-1.3	-0.4
Alzheimer’s Disease (in mother)	1.0	1.1	2.8	-0.8	-1.0	1.7	0.6	-0.1	1.4
HDL Cholesterol	1.0	1.6	3.0	-1.3	1.1	-1.4	-1.0	-0.8	-1.7
Average weekly spirits intake	1.0	1.2	2.8	0.6	1.7	-1.6	-1.2	0.2	0.1
Angina	1.0	1.3	3.2	-1.8	-1.0	0.3	1.1	-1.3	-0.6
Pack years adult smoking proportion	1.0	1.5	5.1	0.7	-1.0	0.8	0.1	1.4	2.2
Bilateral oophorectomy (both ovaries removed)	1.0	1.1	6.0	-2.4	0.0	0.3	0.6	0.2	-0.6
Multivitamins +/- minerals	1.0	1.2	3.1	-0.8	-1.0	-0.3	0.1	-1.8	-1.6
Had other major operations	1.0	1.2	4.2	-2.1	-1.0	0.4	0.8	-0.7	-0.7
Medication: Simvastatin	1.0	1.5	4.0	2.0	0.9	0.1	-1.2	1.5	0.4
Happiness	1.0	1.2	3.0	-1.1	0.0	0.9	1.7	-1.4	-0.2
Length of working week for main job	1.0	1.1	2.5	1.0	0.1	-1.2	-1.2	1.6	-0.5
Exposure to tobacco smoke outside home	1.0	1.3	2.7	0.9	1.1	-1.0	-1.6	1.3	0.6
Number of full brothers	1.0	1.2	2.8	-1.5	-1.3	1.7	0.7	-0.4	0.2
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	2.7	-1.6	-1.4	0.6	1.1	0.4	0.8
Medication: Aspirin	1.0	1.3	4.0	0.6	0.3	1.1	0.1	1.4	2.0
Smoking status: Previous	1.0	1.5	2.9	-1.3	0.4	-1.1	-1.5	-1.7	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.2	5.2	-0.4	-1.9	2.3	1.4	-0.4	1.2
Mood swings	1.0	1.8	5.6	2.4	0.9	0.4	-1.3	1.3	0.9
Ever had bowel cancer screening	1.0	1.1	2.6	-0.1	0.7	-1.3	-1.6	0.6	-1.3
Commuting to job workplace: Walk	1.0	1.1	3.8	0.2	0.1	-1.9	-0.8	0.2	-1.3
Back pain experienced in last month	1.0	1.5	3.0	-1.7	-1.7	0.1	0.8	-1.4	0.8
Breast cancer (self-reported)	1.0	1.2	2.2	-0.5	-1.1	0.7	1.4	1.5	1.1
Leg fat percentage (left)	1.0	3.7	7.9	2.8	2.3	-2.8	-0.2	1.0	0.7
Verbal and Numeric Reasoning (VNR)	0.9	2.3	5.0	1.6	1.8	-2.2	-1.4	0.5	-0.9
Vitamin and mineral supplements	0.9	1.2	3.1	0.4	0.8	0.8	0.8	1.4	1.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.1	2.4	1.4	1.0	-0.9	-1.5	0.2	-0.9
Neuroticism score	0.9	2.0	4.5	2.1	1.8	-0.4	-1.3	1.5	0.1
Qualifications: A levels/AS levels or equivalent	0.9	1.9	5.1	-0.7	-1.0	2.3	1.5	-0.2	1.6
Medication: Paracetamol	0.9	1.6	5.8	-1.0	-0.5	0.5	2.4	-1.4	-0.5
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	4.7	-0.9	-0.8	-2.2	1.5	0.4	-1.6
High blood pressure (siblings)	0.9	1.2	3.5	-0.5	-1.1	0.9	1.1	0.6	1.9
Reason for reducing amount of alcohol drunk: Health precaution	0.9	1.1	3.6	-1.9	-0.2	0.9	0.8	-0.9	-0.6
Angina (self-reported)	0.9	1.2	2.2	-1.5	-1.0	0.2	1.2	-1.4	-0.8
Leg pain on walking	0.9	1.1	2.0	-1.1	-1.2	0.7	1.4	-0.4	1.1
Illnesses of father: Heart disease	0.9	1.3	3.6	-1.9	-0.8	-0.9	-0.1	-1.6	-0.7
Average weekly red wine intake	0.9	1.4	3.2	0.2	1.8	-1.1	-1.8	0.8	-0.0
Qualifications: nursing, teaching	0.9	1.5	3.5	0.2	-0.2	1.3	0.7	1.7	1.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.9	1.1	4.5	-0.3	0.6	-1.1	-0.1	-0.2	-2.1
Cholesterol lowering medication	0.9	1.3	5.6	0.7	-0.1	0.3	0.1	1.2	2.4
Depression (Nagel 2018)	0.8	1.2	6.2	2.5	0.4	-0.4	-0.5	0.2	0.1
HbA1C	0.8	0.9	2.0	0.9	0.7	0.2	-0.9	-1.4	-1.2
Hand grip strength (left)	0.8	2.1	4.3	-0.8	-1.4	1.9	2.1	-0.7	1.2
Diabetes (mother)	0.8	1.0	4.0	0.5	-0.3	2.0	0.4	0.1	1.2
Serious illness, injury or assault to yourself	0.8	0.9	2.0	-0.8	-1.3	1.4	0.9	0.1	0.5
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.0	-1.4	-1.1	0.6	1.1	-1.0	0.1
Fluid intelligence score	0.8	1.7	3.6	1.2	1.5	-1.9	-1.5	0.4	-0.6
Prospective memory result	0.8	0.9	2.0	-0.5	-1.0	1.4	1.1	-0.7	0.7
Mouth/teeth dental problems: Bleeding gums	0.8	1.1	3.0	0.7	0.6	-1.1	-1.7	1.0	-0.5
Birth weight	0.8	1.6	5.7	-0.4	-1.0	1.7	2.4	-0.1	0.4
Alcohol intake frequency.	0.8	1.8	4.1	-1.0	-2.0	1.0	1.9	-0.9	0.7
Financial situation satisfaction	0.8	0.9	2.6	0.8	1.6	-1.2	0.2	1.0	-0.1
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.1	-1.1	-1.1	1.5	0.5	-0.6	0.5
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.9	-0.6	-0.2	-0.5	0.8	-1.3	-1.7
Ulcerative Colitis	0.7	1.0	2.4	0.9	0.8	-0.5	-1.5	0.7	-1.2
Medication for hormone replacement therapy	0.7	0.8	1.6	-1.3	-0.6	0.4	1.1	-1.0	-0.7
Past tobacco smoking	0.7	1.4	4.0	1.6	0.6	0.1	1.1	2.0	0.4
Nervous feelings	0.7	1.4	4.5	2.1	1.7	-0.5	-0.6	0.5	-0.4
Financial difficulties in last 2 years	0.7	1.0	2.2	-0.4	1.1	-1.4	-1.5	0.2	-0.6
Illnesses of mother	0.7	0.9	2.6	-0.3	0.3	1.2	-0.5	-0.8	-1.6
Comparative height size at age 10	0.7	3.8	9.9	-2.5	-3.1	2.2	0.5	-1.0	0.6
Commuting to job workplace: Car/motor vehicle	0.7	0.9	2.5	-0.5	-0.3	0.8	1.3	-0.3	1.6
Arm fat percentage (left)	0.7	3.0	7.0	2.6	1.4	-2.5	0.4	1.3	1.0
Osteoporosis (self-reported)	0.7	0.9	2.0	-1.4	-0.0	-0.6	-1.4	0.2	-1.1
Medication: Aspirin	0.7	0.9	2.2	0.6	0.7	1.0	-0.4	1.1	1.5
Medication: Gliclazide	0.7	0.8	2.1	0.1	1.1	-0.6	-1.4	0.6	-0.8
Average weekly champagne plus white wine intake	0.7	1.0	2.6	1.1	0.6	-0.6	-1.6	0.7	-0.9
Mother’s age at death	0.7	0.9	2.1	0.1	1.4	-0.6	-1.5	1.1	0.1
High cholesterol (Self-reported)	0.7	1.2	3.8	1.9	0.5	-0.1	-1.7	0.3	0.3
Myopia	0.7	1.1	3.0	1.0	0.6	-0.7	-1.7	0.9	0.7
Ovarian Cancer	0.6	0.7	1.3	0.9	1.1	-0.5	-1.0	0.3	-1.0
BMI	0.6	3.3	9.1	1.6	-1.1	1.3	2.1	0.5	3.0
Ever had hysterectomy (womb removed)	0.6	0.7	2.9	0.2	0.3	-1.7	0.1	1.0	0.0
Fed-up feelings	0.6	1.0	2.8	0.6	0.8	-1.1	-0.6	-0.9	-1.7
Weight	0.6	2.9	7.1	0.3	-1.9	1.1	2.3	-0.3	2.7
Arm fat percentage (right)	0.6	2.2	5.8	2.2	1.2	-2.4	0.3	0.8	0.7
Lung cancer (father)	0.6	0.7	1.6	0.6	-0.3	1.3	-0.5	1.0	1.0
Standing height	0.6	5.6	13.2	-2.0	-3.6	3.5	0.9	-1.0	1.6
Glaucoma (self-reported)	0.6	0.7	1.3	0.4	-1.2	-0.6	0.7	-1.2	-0.7
Neck or shoulder pain in last month	0.6	0.9	2.1	-1.0	-0.9	0.8	1.5	0.1	1.0
Heart disease (mother)	0.6	0.7	2.4	-0.7	-0.4	-1.6	-0.1	-1.2	-0.1
Family relationship satisfaction	0.6	0.8	3.8	2.0	0.3	-0.2	0.7	-0.3	-0.2
Loneliness, isolation	0.6	0.9	2.3	0.8	-1.5	1.2	0.9	0.3	0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.3	-0.6	-0.8	1.1	-0.4	-0.5	1.0
Eye problems/disorders: Glaucoma	0.6	0.7	1.2	0.8	-0.7	-1.0	0.6	-0.7	-1.1
Medication: Bendroflumethiazide	0.6	0.8	2.2	0.3	0.8	-0.8	-1.0	1.5	0.6
Medication: Atorvastatin	0.6	0.7	1.2	-0.9	-1.0	-0.3	0.1	-1.0	1.1
Ever smoked	0.6	1.1	1.7	-1.1	-1.1	1.1	-1.1	-1.3	0.5
Pack years of smoking	0.6	0.9	3.3	0.4	-0.6	0.1	-0.0	1.2	1.8
Depressed Affect (Nagel 2018)	0.5	1.1	4.1	2.0	0.9	-0.7	-1.0	0.7	0.1
Alzheimer’s Disease (including proxy)	0.5	0.7	1.4	-1.1	-0.5	1.2	-0.3	-0.9	0.6
Rheumatoid Arthritis	0.5	0.7	1.6	0.6	0.5	-0.1	-1.2	1.3	0.5
Schizophrenia (2014)	0.5	1.0	2.2	-0.6	-1.4	0.3	0.8	-1.5	-0.9
Smoking Status	0.5	1.2	3.6	0.4	-1.1	1.9	-0.1	-1.3	0.8
Allergy or Eczema	0.5	1.3	4.8	0.3	1.0	-2.2	-1.0	0.4	-0.9
Chronotype (morning person)	0.5	1.2	2.4	0.2	0.6	-1.3	-1.5	1.5	0.9
Diabetes (father)	0.5	0.6	1.3	0.4	0.8	-0.3	-0.9	1.1	0.9
Townsend deprivation index at recruitment	0.5	0.6	2.8	0.2	0.1	-0.5	-1.7	-0.1	-0.8
Body mass index (BMI)	0.5	2.1	5.6	1.1	-0.5	-0.2	2.3	0.2	2.4
Waist circumference	0.5	1.8	5.5	1.8	-0.2	-0.6	1.0	0.4	2.3
Heel bone mineral density (BMD) T-score, automated (right)	0.5	1.1	3.9	-0.9	0.6	2.0	0.6	0.0	-1.1
Qualifications: None of the above	0.5	1.1	2.9	0.1	0.6	-1.7	-1.2	-0.4	-1.5
Hip circumference	0.5	2.0	5.8	1.7	-0.9	0.2	1.6	0.5	2.4
Medication: Cholesterol lowering	0.5	0.7	2.1	1.4	0.6	-0.6	-1.2	0.4	0.3
Hair/balding pattern: Pattern 4	0.5	1.2	2.9	1.5	1.0	-0.7	-1.7	0.3	-0.6
Birth weight of first child	0.5	0.9	3.0	-0.3	1.7	-0.9	-0.5	0.4	-1.1
Medication: Amlodipine	0.5	0.7	2.1	-0.4	0.1	0.7	0.0	1.4	1.2
Medication: Allopurinol	0.5	0.6	2.9	-0.2	-0.6	1.7	-0.4	0.2	0.5
Medication: Seretide 50 evohaler	0.5	0.5	1.2	1.0	-0.3	-0.9	-1.1	-0.2	0.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.3	-1.5	-0.1	-0.7	0.8	-0.5	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.5	-0.6	0.3	1.9	1.1	0.3	1.1
Arm fat mass (left)	0.5	2.0	6.1	1.5	-0.5	-0.3	1.7	0.6	2.5
Age started oral contraceptive pill	0.5	0.7	1.5	-0.0	-0.2	1.1	-1.0	0.5	1.2
Alcohol drinker status: Previous	0.5	0.5	1.6	0.1	-1.3	0.8	0.4	0.0	0.8
Leg fat mass (left)	0.5	1.8	4.6	2.0	0.4	-0.8	0.9	0.8	2.1
Intelligence (Savage-Jansen 2018)	0.4	1.3	4.2	1.1	2.1	-1.0	-0.8	0.5	-0.5
Reaction Time	0.4	0.7	2.2	-0.8	-0.2	-0.7	-0.8	-0.0	-1.5
Neuroticism (2016)	0.4	0.5	1.7	-0.6	0.5	-0.4	-1.3	-0.5	-0.8
Primary Biliary Cirrhosis	0.4	0.6	2.5	0.1	-0.5	0.5	-0.9	-0.3	-1.6
Blood White Count	0.4	2.9	8.7	1.2	-0.8	2.0	1.4	0.6	3.0
Frequency of depressed mood in last 2 weeks	0.4	0.5	2.7	1.6	-0.2	-0.1	0.4	0.0	0.3
Trunk fat mass	0.4	1.7	4.2	2.1	0.7	-1.4	0.7	1.0	1.5
Heart attack	0.4	0.5	1.3	1.2	0.5	0.3	-1.0	-0.1	0.6
Time employed in main current job	0.4	0.5	1.3	0.9	0.8	0.1	-1.2	0.1	-0.1
Pulse rate	0.4	0.6	2.5	0.3	-0.0	0.6	0.5	-0.8	1.6
Arm fat mass (right)	0.4	1.6	4.5	1.5	-0.2	-0.6	1.5	0.5	2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	2.3	1.1	1.5	-0.5	-0.4	0.3	0.4
Gout (self-reported)	0.4	0.6	0.9	-1.0	0.7	0.7	-0.8	-0.9	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.2	0.7	0.7	-0.3	0.5	0.9	1.1
Wheeze or whistling in the chest in last year	0.4	0.6	2.1	-1.4	-0.8	0.3	-0.5	-0.8	0.3
Eye problems/disorders: None of the above	0.4	0.5	1.2	-1.1	-0.3	0.7	0.2	0.0	1.0
Whole body fat mass	0.4	1.7	3.7	1.9	0.5	-1.2	0.9	0.9	1.8
Leg fat mass (right)	0.4	1.7	4.0	2.0	0.5	-1.0	0.7	0.9	1.9
Number of full sisters	0.4	0.5	1.4	-0.3	-1.2	0.3	-0.2	0.3	1.0
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.2	0.4	-0.8	0.1	0.4	1.1	0.9
Mineral and other dietary supplements	0.4	0.5	1.2	0.1	-0.6	1.1	-0.0	0.7	0.9
Number of self-reported non-cancer illnesses	0.4	0.7	1.9	-1.4	-1.1	-0.2	0.6	-0.2	0.9
Number of operations (self-reported)	0.4	0.6	1.9	-1.4	-1.2	-0.3	-0.3	0.1	0.3
Average weekly beer plus cider intake	0.4	0.6	1.1	-0.7	0.4	-0.9	-0.5	-1.1	-0.6
Diastolic blood pressure, automated reading	0.4	1.1	3.9	-0.1	-0.5	0.7	2.0	-0.8	1.2
Ever depressed for a whole week	0.4	0.4	1.3	0.6	0.7	1.1	-0.3	0.1	-0.7
Unable to work because of sickness or disability	0.4	0.5	1.6	1.3	-0.1	-0.9	-0.6	0.2	-0.4
Heart attack/myocardial infarction (self-reported)	0.4	0.5	1.4	0.9	0.0	0.4	-1.2	-0.2	0.7
Heart disease (siblings)	0.4	0.5	2.3	-1.5	-0.7	0.2	-0.3	-0.2	-0.1
Bipolar Disorder (2018)	0.3	0.5	2.0	0.7	0.3	-0.0	0.5	0.2	1.4
Prostate Cancer	0.3	0.4	1.4	0.6	0.1	-0.6	-0.6	0.2	-1.2
Crohns Disease (2012)	0.3	0.6	1.1	-0.6	-0.6	1.0	-0.6	-1.1	0.0
Height	0.3	6.7	16.4	-2.3	-4.0	3.7	0.1	-1.7	1.2
Systolic Blood Pressure	0.3	1.5	4.5	-0.2	-0.7	1.3	1.6	0.0	2.1
Lung FEV1/FVC ratio	0.3	1.7	4.4	2.1	0.8	1.1	1.5	0.4	1.3
Lung FVC	0.3	1.3	2.9	-1.7	-0.5	1.5	1.1	-0.3	-1.0
Sensitivity / hurt feelings	0.3	0.5	1.4	0.8	0.2	-0.2	-1.2	0.8	0.3
Taking other prescription medications	0.3	0.4	1.9	-0.4	0.2	-1.4	0.5	0.4	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.5	-0.7	0.9	1.2	0.2	0.4	-0.9
High blood pressure	0.3	0.7	1.7	1.3	-0.1	0.4	-0.6	0.9	1.1
Hayfever, allergic rhinitis or eczema	0.3	0.7	1.9	0.3	1.0	-1.4	-0.7	0.7	0.2
Chronic bronchitis/emphysema (father)	0.3	0.4	1.0	0.4	1.0	0.8	-0.5	0.2	-0.4
High blood pressure (mother)	0.3	0.4	1.0	-0.5	-0.1	-0.5	0.2	1.0	0.9
Hair/balding pattern: Pattern 2	0.3	0.3	1.2	-0.3	0.3	-0.1	1.1	0.4	-0.7
Allergy	0.3	0.6	2.2	-0.0	-0.4	1.5	0.9	-0.5	-0.4
Worrier / anxious feelings	0.3	0.6	1.5	0.5	1.2	-0.3	-1.0	0.3	-0.8
Falls in the last year	0.3	0.4	1.4	0.0	-0.8	-0.1	-1.2	-0.4	-0.7
Noisy workplace	0.3	0.4	1.4	-1.2	-0.5	0.0	0.2	-0.3	-0.6
Breastfed as a baby	0.3	0.4	1.1	-0.0	0.5	-1.1	-0.8	0.4	-0.2
Shortness of breath walking on level ground	0.3	0.4	0.8	0.3	0.5	-0.6	-0.7	-0.9	-0.5
Knee pain experienced in last month	0.3	0.4	0.8	0.3	-0.1	-0.6	0.7	0.9	0.7
Friendships satisfaction	0.3	0.3	1.1	-0.2	-0.5	1.1	0.6	0.4	0.3
Medication for cholesterol	0.3	0.5	1.3	0.5	0.2	-0.8	-0.8	0.2	-1.1
Ever taken oral contraceptive pill	0.3	0.4	1.6	0.1	0.1	-0.4	-1.3	0.2	-0.6
Medication: Blood pressure	0.3	0.6	3.3	-0.0	0.3	0.1	-0.4	0.2	1.8
Pain type(s) experienced in last month: Hip pain	0.3	0.4	0.8	-0.6	-0.7	-0.1	0.9	-0.3	0.6
Alcohol drinker status: Never	0.3	0.4	0.8	-0.8	-0.4	-0.2	0.7	-0.9	-0.1
Risk taking	0.3	0.5	0.8	-0.9	0.7	-0.6	-0.9	-0.5	-0.5
Schizophrenia (2018)	0.2	0.4	1.1	-0.1	-1.0	0.8	0.1	-0.7	-0.5
Crohns Disease (2017)	0.2	0.4	1.4	-0.5	-0.5	0.3	-1.2	-0.2	-0.5
Ulcerative Colitis (UC)	0.2	0.4	1.5	-0.3	-0.2	1.2	0.3	-0.1	-0.8
Mean Putamen Volume	0.2	0.3	0.6	-0.1	0.3	-0.5	-0.8	-0.7	0.4
Blood Eosinophil Count	0.2	1.5	3.0	1.7	1.2	-0.2	-1.7	1.0	0.9
Blood Platelet Count	0.2	1.8	5.1	1.7	0.5	1.3	0.4	0.7	2.3
Blood Red Count	0.2	1.6	3.0	-1.4	-0.3	0.8	-1.5	1.3	1.7
Heel T-Score	0.2	1.9	7.0	1.1	2.6	-1.2	-0.1	1.4	-0.3
Cardiovascular Disease	0.2	0.6	1.6	0.3	-0.8	1.3	0.3	-0.9	0.3
Hair Pigment	0.2	6.9	13.0	-0.2	-3.2	3.6	2.3	-1.0	3.4
Number of treatments/medications taken	0.2	0.4	1.1	-0.4	-0.2	-0.2	1.1	-0.7	0.6
Severe depression (siblings)	0.2	0.3	0.9	-0.9	-0.3	-0.3	-0.1	-0.6	-0.4
Age when periods started (menarche)	0.2	0.6	2.6	0.2	0.5	-0.3	-0.7	-1.6	-0.2
Number of incorrect matches in round	0.2	0.4	1.3	0.1	0.6	-1.1	0.4	-0.1	-0.8
Pain all over the body in last month	0.2	0.2	0.5	-0.4	-0.7	-0.5	-0.4	0.2	0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.0	0.3	1.0	0.7	-0.3	-0.0	0.3
Number of live births	0.2	0.3	1.0	-0.5	-0.5	1.0	0.0	0.5	0.4
Asthma	0.2	0.4	1.4	0.0	-0.5	-0.7	-0.6	0.2	1.2
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.6	0.0	0.8	-0.6	-0.1	0.2	-0.6
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.4	-1.2	0.1	-0.3	0.5	-0.3	0.0
Emphysema/chronic bronchitis	0.2	0.3	0.5	-0.5	-0.7	0.6	-0.4	-0.3	-0.5
Medication: Blood pressure	0.2	0.3	1.0	0.6	-0.3	1.0	-0.3	0.7	-0.2
Medication: Omeprazole	0.2	0.2	0.5	-0.6	-0.7	0.0	0.5	0.3	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.5	0.7	0.4	0.4	-0.2	-0.7	-0.1
Chest pain or discomfort	0.2	0.2	0.7	-0.8	-0.4	-0.1	0.6	0.5	0.0
Hypertension (Self-reported)	0.2	0.5	1.4	1.2	0.1	0.0	-0.8	0.8	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.3	0.8	-0.1	0.4	-0.4	-0.1	-0.6	-0.9
Long-standing illness, disability or infirmity	0.2	0.4	1.5	0.5	1.2	-0.3	-0.5	0.2	-0.0
Asthma (self-reported)	0.2	0.4	1.0	-0.1	-0.3	-0.8	-0.7	0.2	1.0
Miserableness	0.2	0.4	1.1	0.3	-0.5	1.1	-0.2	0.3	0.7
Hearing aid user	0.2	0.2	1.1	0.1	-0.1	-0.1	1.1	0.4	-0.3
Medication: Lisinopril	0.2	0.3	1.1	-0.0	-0.1	-0.1	-0.5	0.4	1.1
Fractured/broken bones in last 5 years	0.2	0.3	0.8	-0.4	-0.1	-0.7	-0.9	0.0	0.5
Vascular/heart problems diagnosed by doctor	0.2	0.5	0.9	-1.0	-0.0	-0.2	0.9	-0.6	-0.8
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.4	0.2	0.4	-0.6	-0.5	0.3	-0.6
Pain experienced in last month	0.2	0.4	0.9	0.9	0.9	0.1	-0.6	0.1	-0.7
Bipolar Disorder or Schizophrenia	0.1	0.3	0.6	0.2	-0.6	0.8	0.5	-0.4	0.5
Irritable Bowel Disease (IBD)	0.1	0.3	1.3	-0.4	-0.2	0.5	-0.5	-0.1	-1.1
Lupus	0.1	0.2	0.6	-0.8	0.3	0.0	0.5	-0.0	-0.4
Respiratory disease	0.1	0.3	0.5	-0.0	-0.6	-0.4	-0.5	0.7	0.6
Systolic blood pressure, automated reading	0.1	0.4	1.3	0.3	0.5	-0.2	1.1	-0.5	0.4
Maternal smoking around birth	0.1	0.2	0.2	0.5	0.5	-0.4	-0.4	0.5	0.0
Hearing difficulty/problems with background noise	0.1	0.2	0.7	0.2	0.3	0.4	0.7	-0.8	0.0
Alcohol intake versus 10 years previously	0.1	0.2	0.8	0.9	0.0	0.2	0.2	0.2	-0.3
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	1.0	0.2	0.2	0.3	0.2	-0.1	1.0
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.4	0.2	-0.2	-0.6	-0.4	-0.6	0.1
Number of children fathered	0.1	0.1	0.4	-0.2	0.4	0.2	0.1	0.2	0.6
Health satisfaction	0.1	0.2	0.7	0.2	0.4	-0.2	-0.3	0.9	0.2
Qualifications: College or University degree	0.1	0.3	0.8	0.7	0.9	0.1	-0.4	-0.1	-0.3
Pulse rate, automated reading	0.1	0.4	0.9	0.8	0.9	-0.2	0.4	-0.9	-0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.3	-0.1	0.4	0.2	0.4	0.5	0.2
Illnesses of siblings: Diabetes	0.1	0.2	0.3	-0.2	0.5	-0.6	-0.5	-0.1	-0.3
Eye problems/disorders: Cataract	0.1	0.1	0.3	-0.4	0.1	0.4	0.4	-0.6	0.2
Schizophrenia vs Biploar Disorder	0.0	0.1	0.2	0.0	-0.4	0.5	0.1	0.0	0.0
Major Depression (MDD)	0.0	0.0	0.3	0.0	0.0	0.5	0.0	0.0	0.0
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Coronary Artery Disease (CAD)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Waist Hip Ratio (WHR)	0.0	0.1	0.5	-0.2	0.4	-0.2	0.3	-0.7	-0.0
Tanning	0.0	0.6	1.4	1.0	0.7	0.3	-1.2	0.6	0.4
Had major operations	0.0	0.0	0.1	-0.1	-0.1	-0.2	0.3	0.4	0.0

Hub : Genes

FUZ

Models

Trait associations