Hub : Genes

FUZ

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.2670 0.0540 4.6e-09 0.041 0.101 0.111 0.042 0.047 8.8e-06 2.9e-12 2.4e-13 6.5e-06 1.9e-06
2 GTEx Muscle Skeletal 0.0856 0.0286 5.4e-05 0.062 NA 0.033 NA -0.002 1.1e-06 NA 3.2e-04 NA 6.1e-01
3 GTEx Testis 0.2380 0.0710 1.0e-04 0.057 NA 0.167 NA 0.150 1.5e-03 NA 6.8e-08 NA 3.4e-07
4 GTEx Thyroid 0.0850 0.0330 1.3e-03 0.000 NA 0.009 NA 0.004 2.9e-01 NA 6.5e-02 NA 1.4e-01
5 TCGA Brain Lower Grade Glioma 0.1074 0.0424 3.1e-06 0.051 0.052 0.057 NA 0.039 1.7e-06 1.4e-06 4.6e-07 NA 2.8e-05
6 TCGA Ovarian Serous Cystadenocarcinoma 0.1460 0.0610 3.7e-04 0.075 0.041 0.027 NA 0.062 8.9e-06 9.2e-04 6.1e-03 NA 5.3e-05

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.3 0.5 2.0 0.7 0.3 -0.0 0.5 0.2 1.4
Bipolar Disorder or Schizophrenia 0.1 0.3 0.6 0.2 -0.6 0.8 0.5 -0.4 0.5
Depressed Affect (Nagel 2018) 0.5 1.1 4.1 2.0 0.9 -0.7 -1.0 0.7 0.1
Depression (Nagel 2018) 0.8 1.2 6.2 2.5 0.4 -0.4 -0.5 0.2 0.1
Intelligence (Savage-Jansen 2018) 0.4 1.3 4.2 1.1 2.1 -1.0 -0.8 0.5 -0.5
Neuroticism (Nagel 2018) 1.4 3.3 6.8 2.6 2.1 -1.6 -2.2 0.9 -0.2
Schizophrenia (2018) 0.2 0.4 1.1 -0.1 -1.0 0.8 0.1 -0.7 -0.5
Schizophrenia vs Biploar Disorder 0.0 0.1 0.2 0.0 -0.4 0.5 0.1 0.0 0.0
Worry (Nagel 2018) 2.1 4.4 11.0 3.3 2.7 -1.7 -1.7 1.3 -0.9
Alzheimer’s Disease (in mother) 1.0 1.1 2.8 -0.8 -1.0 1.7 0.6 -0.1 1.4
Alzheimer’s Disease (in father) 1.1 1.2 4.0 -1.4 -1.0 0.2 0.1 -2.0 -0.6
Alzheimer’s Disease (including proxy) 0.5 0.7 1.4 -1.1 -0.5 1.2 -0.3 -0.9 0.6
Crohns Disease (2017) 0.2 0.4 1.4 -0.5 -0.5 0.3 -1.2 -0.2 -0.5
Irritable Bowel Disease (IBD) 0.1 0.3 1.3 -0.4 -0.2 0.5 -0.5 -0.1 -1.1
Ulcerative Colitis (UC) 0.2 0.4 1.5 -0.3 -0.2 1.2 0.3 -0.1 -0.8
Major Depression (MDD) 0.0 0.0 0.3 0.0 0.0 0.5 0.0 0.0 0.0
Reaction Time 0.4 0.7 2.2 -0.8 -0.2 -0.7 -0.8 -0.0 -1.5
Verbal and Numeric Reasoning (VNR) 0.9 2.3 5.0 1.6 1.8 -2.2 -1.4 0.5 -0.9
Breast Cancer 1.4 3.5 7.4 -2.7 0.5 -1.6 -1.4 -1.9 -2.2
Ovarian Cancer 0.6 0.7 1.3 0.9 1.1 -0.5 -1.0 0.3 -1.0
Prostate Cancer 0.3 0.4 1.4 0.6 0.1 -0.6 -0.6 0.2 -1.2
Age at First Birth 1.9 2.8 6.2 1.8 2.5 -1.0 -2.2 1.2 0.1
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.2 1.6 4.7 1.1 -0.3 0.2 0.4 2.2 1.8
Coronary Artery Disease (CAD) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Crohns Disease (2012) 0.3 0.6 1.1 -0.6 -0.6 1.0 -0.6 -1.1 0.0
Mean Putamen Volume 0.2 0.3 0.6 -0.1 0.3 -0.5 -0.8 -0.7 0.4
Fasting Glucose 2.1 2.5 5.5 -2.3 -1.6 0.5 1.2 -2.2 -0.6
HbA1C 0.8 0.9 2.0 0.9 0.7 0.2 -0.9 -1.4 -1.2
HDL Cholesterol 1.0 1.6 3.0 -1.3 1.1 -1.4 -1.0 -0.8 -1.7
LDL Cholesterol 1.5 2.4 4.8 0.3 -1.2 1.1 1.6 2.0 2.2
Lupus 0.1 0.2 0.6 -0.8 0.3 0.0 0.5 -0.0 -0.4
Neuroticism (2016) 0.4 0.5 1.7 -0.6 0.5 -0.4 -1.3 -0.5 -0.8
Primary Biliary Cirrhosis 0.4 0.6 2.5 0.1 -0.5 0.5 -0.9 -0.3 -1.6
Rheumatoid Arthritis 0.5 0.7 1.6 0.6 0.5 -0.1 -1.2 1.3 0.5
Schizophrenia (2014) 0.5 1.0 2.2 -0.6 -1.4 0.3 0.8 -1.5 -0.9
Triglycerides 1.9 3.1 8.0 0.4 -1.4 1.7 1.5 1.8 2.8
Type 2 Diabetes (T2D) (2012) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Ulcerative Colitis 0.7 1.0 2.4 0.9 0.8 -0.5 -1.5 0.7 -1.2
Blood Eosinophil Count 0.2 1.5 3.0 1.7 1.2 -0.2 -1.7 1.0 0.9
Blood Platelet Count 0.2 1.8 5.1 1.7 0.5 1.3 0.4 0.7 2.3
Blood Red Count 0.2 1.6 3.0 -1.4 -0.3 0.8 -1.5 1.3 1.7
Blood White Count 0.4 2.9 8.7 1.2 -0.8 2.0 1.4 0.6 3.0
Heel T-Score 0.2 1.9 7.0 1.1 2.6 -1.2 -0.1 1.4 -0.3
BMI 0.6 3.3 9.1 1.6 -1.1 1.3 2.1 0.5 3.0
Height 0.3 6.7 16.4 -2.3 -4.0 3.7 0.1 -1.7 1.2
Waist Hip Ratio (WHR) 0.0 0.1 0.5 -0.2 0.4 -0.2 0.3 -0.7 -0.0
Systolic Blood Pressure 0.3 1.5 4.5 -0.2 -0.7 1.3 1.6 0.0 2.1
Smoking Status 0.5 1.2 3.6 0.4 -1.1 1.9 -0.1 -1.3 0.8
Allergy or Eczema 0.5 1.3 4.8 0.3 1.0 -2.2 -1.0 0.4 -0.9
Cardiovascular Disease 0.2 0.6 1.6 0.3 -0.8 1.3 0.3 -0.9 0.3
Hypothyroidism (self reported) 1.2 2.7 6.1 -1.1 -0.9 -2.5 1.9 0.3 -2.1
Respiratory disease 0.1 0.3 0.5 -0.0 -0.6 -0.4 -0.5 0.7 0.6
Type 2 Diabetes (T2D) (2018) 2.3 4.4 9.9 2.6 1.3 -0.6 -1.2 3.1 2.4
Lung FEV1/FVC ratio 0.3 1.7 4.4 2.1 0.8 1.1 1.5 0.4 1.3
Lung FVC 0.3 1.3 2.9 -1.7 -0.5 1.5 1.1 -0.3 -1.0
Neuroticism 2.9 7.0 13.2 3.3 3.6 -1.9 -3.0 2.1 -0.8
Chronotype (morning person) 0.5 1.2 2.4 0.2 0.6 -1.3 -1.5 1.5 0.9
Hair Pigment 0.2 6.9 13.0 -0.2 -3.2 3.6 2.3 -1.0 3.4
Tanning 0.0 0.6 1.4 1.0 0.7 0.3 -1.2 0.6 0.4
Hand grip strength (left) 0.8 2.1 4.3 -0.8 -1.4 1.9 2.1 -0.7 1.2
Number of treatments/medications taken 0.2 0.4 1.1 -0.4 -0.2 -0.2 1.1 -0.7 0.6
Average weekly spirits intake 1.0 1.2 2.8 0.6 1.7 -1.6 -1.2 0.2 0.1
Sensitivity / hurt feelings 0.3 0.5 1.4 0.8 0.2 -0.2 -1.2 0.8 0.3
Frequency of depressed mood in last 2 weeks 0.4 0.5 2.7 1.6 -0.2 -0.1 0.4 0.0 0.3
Hearing difficulty/problems: Yes 1.6 2.5 5.1 -2.0 -1.1 1.6 2.3 -1.3 0.7
Relative age of first facial hair 1.4 2.9 11.5 1.4 1.3 -1.2 -3.4 -0.0 -1.2
Other serious medical condition/disability diagnosed by doctor 2.6 3.3 7.7 -2.2 -2.8 0.9 0.7 -2.1 -1.2
Ever used hormone-replacement therapy (HRT) 1.5 1.9 4.2 -1.7 0.7 -1.3 -1.4 -0.8 -2.0
Ever had hysterectomy (womb removed) 0.6 0.7 2.9 0.2 0.3 -1.7 0.1 1.0 0.0
Systolic blood pressure, automated reading 0.1 0.4 1.3 0.3 0.5 -0.2 1.1 -0.5 0.4
Eye problems/disorders: Diabetes related eye disease 1.8 2.0 4.6 1.3 1.7 -1.0 -2.1 0.9 -1.1
Angina 1.0 1.3 3.2 -1.8 -1.0 0.3 1.1 -1.3 -0.6
Medication for hormone replacement therapy 0.7 0.8 1.6 -1.3 -0.6 0.4 1.1 -1.0 -0.7
Vitamin and mineral supplements 0.9 1.2 3.1 0.4 0.8 0.8 0.8 1.4 1.8
Supplements: Zinc 1.5 1.6 6.6 0.3 1.0 -2.6 -0.6 0.3 -1.2
Medication: Co-codamol 1.2 1.4 5.3 -1.2 0.5 -2.3 -0.7 0.2 -0.9
Medication: Metformin 4.1 5.8 9.5 2.8 2.3 -2.0 -2.5 3.1 1.5
Diabetes (father) 0.5 0.6 1.3 0.4 0.8 -0.3 -0.9 1.1 0.9
Diabetes (mother) 0.8 1.0 4.0 0.5 -0.3 2.0 0.4 0.1 1.2
Severe depression (siblings) 0.2 0.3 0.9 -0.9 -0.3 -0.3 -0.1 -0.6 -0.4
Pack years adult smoking proportion 1.0 1.5 5.1 0.7 -1.0 0.8 0.1 1.4 2.2
Impedance of leg (right) 2.6 12.7 23.3 1.8 4.1 -3.6 -4.8 0.7 -4.4
Leg fat-free mass (left) 1.6 8.3 15.2 -1.1 -3.7 3.2 3.1 -0.5 3.9
Trunk fat percentage 1.1 4.5 9.1 3.0 2.3 -3.0 -0.8 1.7 0.3
Hand grip strength (right) 1.6 4.4 9.2 -2.0 -1.8 3.0 2.6 -1.5 0.9
Townsend deprivation index at recruitment 0.5 0.6 2.8 0.2 0.1 -0.5 -1.7 -0.1 -0.8
Current tobacco smoking 2.4 3.9 8.8 -0.5 -2.8 3.0 1.8 -1.3 1.2
Average weekly fortified wine intake 1.2 1.4 3.6 -0.9 -1.4 1.4 0.6 -0.2 1.9
Maternal smoking around birth 0.1 0.2 0.2 0.5 0.5 -0.4 -0.4 0.5 0.0
Fed-up feelings 0.6 1.0 2.8 0.6 0.8 -1.1 -0.6 -0.9 -1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.1 2.4 1.4 1.0 -0.9 -1.5 0.2 -0.9
Relative age voice broke 3.8 5.8 15.8 1.9 2.5 -2.5 -4.0 0.5 -1.7
Taking other prescription medications 0.3 0.4 1.9 -0.4 0.2 -1.4 0.5 0.4 -0.2
Age when periods started (menarche) 0.2 0.6 2.6 0.2 0.5 -0.3 -0.7 -1.6 -0.2
Bilateral oophorectomy (both ovaries removed) 1.0 1.1 6.0 -2.4 0.0 0.3 0.6 0.2 -0.6
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.6 1.5 -0.7 0.9 1.2 0.2 0.4 -0.9
Tinnitus: Yes, but not now, but have in the past 1.8 1.9 4.0 1.7 1.8 0.4 -1.1 2.0 0.3
Qualifications: CSEs or equivalent 1.7 2.2 6.2 -0.7 -1.1 2.2 0.3 -0.5 2.5
Serious illness, injury or assault to yourself 0.8 0.9 2.0 -0.8 -1.3 1.4 0.9 0.1 0.5
High blood pressure 0.3 0.7 1.7 1.3 -0.1 0.4 -0.6 0.9 1.1
Hayfever, allergic rhinitis or eczema 0.3 0.7 1.9 0.3 1.0 -1.4 -0.7 0.7 0.2
Multivitamins +/- minerals 1.0 1.2 3.1 -0.8 -1.0 -0.3 0.1 -1.8 -1.6
Stomach or abdominal pain in last month 1.2 1.4 2.5 -1.6 -1.4 1.4 0.2 -1.1 1.1
Supplements: Glucosamine 1.1 1.4 3.3 1.0 1.8 -1.0 -1.8 -0.5 -0.2
Diverticular disease/diverticulitis (self-reported) 0.8 1.0 2.0 -1.4 -1.1 0.6 1.1 -1.0 0.1
Medication: Atenolol 1.2 1.5 4.9 -1.7 -0.6 0.0 2.2 -0.8 -0.1
Medication: Levothyroxine sodium 1.1 1.9 6.4 -0.8 -0.7 -2.5 1.2 0.2 -1.6
Sitting height 1.2 8.7 20.3 -2.0 -3.7 4.5 2.4 -1.4 2.5
Chronic bronchitis/emphysema (father) 0.3 0.4 1.0 0.4 1.0 0.8 -0.5 0.2 -0.4
High blood pressure (mother) 0.3 0.4 1.0 -0.5 -0.1 -0.5 0.2 1.0 0.9
Body mass index (BMI) 0.5 2.1 5.6 1.1 -0.5 -0.2 2.3 0.2 2.4
Impedance of leg (left) 2.2 10.9 20.1 1.5 3.8 -3.3 -4.5 0.6 -4.1
Leg predicted mass (left) 1.6 8.2 15.1 -1.1 -3.7 3.1 3.1 -0.5 3.9
Trunk fat mass 0.4 1.7 4.2 2.1 0.7 -1.4 0.7 1.0 1.5
Waist circumference 0.5 1.8 5.5 1.8 -0.2 -0.6 1.0 0.4 2.3
Number of incorrect matches in round 0.2 0.4 1.3 0.1 0.6 -1.1 0.4 -0.1 -0.8
Past tobacco smoking 0.7 1.4 4.0 1.6 0.6 0.1 1.1 2.0 0.4
Alcohol usually taken with meals 1.4 2.3 4.5 1.8 1.6 -1.5 -1.2 2.1 0.3
Nervous feelings 0.7 1.4 4.5 2.1 1.7 -0.5 -0.6 0.5 -0.4
Frequency of tenseness / restlessness in last 2 weeks 1.4 2.2 4.0 2.0 1.5 -1.8 -1.2 1.2 -0.8
Hearing difficulty/problems with background noise 0.1 0.2 0.7 0.2 0.3 0.4 0.7 -0.8 0.0
Hair/balding pattern: Pattern 2 0.3 0.3 1.2 -0.3 0.3 -0.1 1.1 0.4 -0.7
Had menopause 2.5 3.1 8.2 0.9 1.6 -2.9 -2.0 1.6 -0.7
Had other major operations 1.0 1.2 4.2 -2.1 -1.0 0.4 0.8 -0.7 -0.7
Forced vital capacity (FVC) 1.3 4.8 15.3 -2.2 -2.4 3.9 1.0 -1.4 0.3
Heel bone mineral density (BMD) T-score, automated (right) 0.5 1.1 3.9 -0.9 0.6 2.0 0.6 0.0 -1.1
Ever unenthusiastic/disinterested for a whole week 1.1 1.4 3.8 0.4 0.7 1.1 -1.6 -0.1 -1.9
Qualifications: None of the above 0.5 1.1 2.9 0.1 0.6 -1.7 -1.2 -0.4 -1.5
Financial difficulties in last 2 years 0.7 1.0 2.2 -0.4 1.1 -1.4 -1.5 0.2 -0.6
Mouth/teeth dental problems 1.9 2.9 6.5 -0.7 -2.1 2.6 1.7 -1.1 1.4
Heart attack 0.4 0.5 1.3 1.2 0.5 0.3 -1.0 -0.1 0.6
Allergy 0.3 0.6 2.2 -0.0 -0.4 1.5 0.9 -0.5 -0.4
Pain all over the body in last month 0.2 0.2 0.5 -0.4 -0.7 -0.5 -0.4 0.2 0.1
Diabetes (self-reported) 2.0 3.1 4.9 1.8 1.7 -1.8 -2.2 1.8 1.2
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 1.0 0.3 1.0 0.7 -0.3 -0.0 0.3
Medication: Ramipril 1.8 2.3 3.3 1.7 1.4 -1.5 -1.8 1.8 -0.1
Medication: Simvastatin 1.0 1.5 4.0 2.0 0.9 0.1 -1.2 1.5 0.4
Fluid intelligence score 0.8 1.7 3.6 1.2 1.5 -1.9 -1.5 0.4 -0.6
Illnesses of siblings 1.1 1.5 2.8 1.7 1.3 -1.2 -1.6 0.2 -0.9
Neuroticism score 0.9 2.0 4.5 2.1 1.8 -0.4 -1.3 1.5 0.1
Weight 0.6 2.9 7.1 0.3 -1.9 1.1 2.3 -0.3 2.7
Impedance of arm (right) 3.2 14.9 26.3 1.8 3.9 -4.6 -5.1 1.5 -4.6
Arm fat percentage (right) 0.6 2.2 5.8 2.2 1.2 -2.4 0.3 0.8 0.7
Trunk fat-free mass 3.0 17.4 30.4 -3.0 -5.5 4.8 4.7 -2.0 4.1
Hip circumference 0.5 2.0 5.8 1.7 -0.9 0.2 1.6 0.5 2.4
Time employed in main current job 0.4 0.5 1.3 0.9 0.8 0.1 -1.2 0.1 -0.1
Alcohol intake versus 10 years previously 0.1 0.2 0.8 0.9 0.0 0.2 0.2 0.2 -0.3
Father’s age at death 1.9 2.5 5.3 2.2 2.3 -0.3 -1.1 1.9 0.2
Worrier / anxious feelings 0.3 0.6 1.5 0.5 1.2 -0.3 -1.0 0.3 -0.8
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 1.0 0.2 0.2 0.3 0.2 -0.1 1.0
Falls in the last year 0.3 0.4 1.4 0.0 -0.8 -0.1 -1.2 -0.4 -0.7
Hair/balding pattern: Pattern 3 1.1 1.7 4.8 -2.2 -0.9 -0.3 0.7 -1.6 -1.2
Number of live births 0.2 0.3 1.0 -0.5 -0.5 1.0 0.0 0.5 0.4
Forced expiratory volume in 1-second (FEV1) 1.3 4.3 15.1 -1.6 -1.8 3.9 1.5 -1.4 0.4
Pulse rate 0.4 0.6 2.5 0.3 -0.0 0.6 0.5 -0.8 1.6
Happiness 1.0 1.2 3.0 -1.1 0.0 0.9 1.7 -1.4 -0.2
Noisy workplace 0.3 0.4 1.4 -1.2 -0.5 0.0 0.2 -0.3 -0.6
Qualifications: A levels/AS levels or equivalent 0.9 1.9 5.1 -0.7 -1.0 2.3 1.5 -0.2 1.6
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 3.3 1.0 0.9 -1.4 -1.8 0.6 1.0
Mouth/teeth dental problems: Dentures 1.6 2.6 4.8 1.1 2.2 -1.7 -2.0 1.2 -1.3
Asthma 0.2 0.4 1.4 0.0 -0.5 -0.7 -0.6 0.2 1.2
Medication: Ibuprofen (e.g. Nurofen) 4.2 5.4 11.8 -3.4 -1.9 1.6 2.6 -2.7 -0.6
Medication: Cholesterol lowering 0.5 0.7 2.1 1.4 0.6 -0.6 -1.2 0.4 0.3
Depression (self-reported) 1.6 1.9 5.5 1.3 2.3 -0.8 -0.3 1.6 -0.8
Medication: Lansoprazole 2.3 2.6 5.2 -0.1 2.3 -1.6 -2.2 0.1 -1.6
Prospective memory result 0.8 0.9 2.0 -0.5 -1.0 1.4 1.1 -0.7 0.7
Lung cancer (father) 0.6 0.7 1.6 0.6 -0.3 1.3 -0.5 1.0 1.0
Illnesses of mother 0.7 0.9 2.6 -0.3 0.3 1.2 -0.5 -0.8 -1.6
Forced expiratory volume in 1-second (FEV1), Best measure 1.3 4.3 10.9 -1.7 -1.7 3.3 2.7 -1.3 -0.3
Pulse wave Arterial Stiffness index 1.6 1.8 4.2 -1.6 -2.0 0.4 1.6 -0.8 1.0
Impedance of arm (left) 3.1 14.6 23.9 2.2 4.0 -4.6 -4.9 1.9 -4.2
Arm fat mass (right) 0.4 1.6 4.5 1.5 -0.2 -0.6 1.5 0.5 2.1
Trunk predicted mass 3.0 17.4 29.8 -2.9 -5.5 4.7 4.7 -1.9 4.2
Standing height 0.6 5.6 13.2 -2.0 -3.6 3.5 0.9 -1.0 1.6
Length of working week for main job 1.0 1.1 2.5 1.0 0.1 -1.2 -1.2 1.6 -0.5
Exposure to tobacco smoke at home 1.9 2.2 3.0 1.5 1.6 -1.4 -1.5 0.8 -1.7
Breastfed as a baby 0.3 0.4 1.1 -0.0 0.5 -1.1 -0.8 0.4 -0.2
Tense / ‘highly strung’ 1.3 2.1 5.5 2.4 1.4 0.4 -0.1 2.2 0.1
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.7 2.3 1.1 1.5 -0.5 -0.4 0.3 0.4
Hair/balding pattern: Pattern 4 0.5 1.2 2.9 1.5 1.0 -0.7 -1.7 0.3 -0.6
Birth weight of first child 0.5 0.9 3.0 -0.3 1.7 -0.9 -0.5 0.4 -1.1
Peak expiratory flow (PEF) 1.4 3.4 7.3 -0.8 -2.1 2.7 2.0 -1.4 1.5
Pulse wave reflection index 2.6 3.2 8.1 -1.7 -2.8 1.6 1.9 -0.8 1.2
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.6 0.0 0.8 -0.6 -0.1 0.2 -0.6
Loud music exposure frequency 1.4 1.5 5.2 1.3 1.2 -0.4 -0.8 2.3 0.2
Qualifications: O levels/GCSEs or equivalent 1.3 2.1 4.3 -0.0 -1.4 2.1 1.6 0.2 2.0
Mouth/teeth dental problems: Bleeding gums 0.8 1.1 3.0 0.7 0.6 -1.1 -1.7 1.0 -0.5
Blood clot in the leg (DVT) 1.5 2.0 4.4 -1.2 -1.5 2.1 1.8 -0.4 0.7
Medication: Paracetamol 0.9 1.6 5.8 -1.0 -0.5 0.5 2.4 -1.4 -0.5
Headache pain in last month 2.0 3.4 6.5 -1.2 -2.5 1.5 2.5 -0.8 1.9
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 1.4 -1.2 0.1 -0.3 0.5 -0.3 0.0
Glaucoma (self-reported) 0.6 0.7 1.3 0.4 -1.2 -0.6 0.7 -1.2 -0.7
Gout (self-reported) 0.4 0.6 0.9 -1.0 0.7 0.7 -0.8 -0.9 -0.6
Hypothyroidism/myxoedema (self-reported) 0.9 1.8 4.7 -0.9 -0.8 -2.2 1.5 0.4 -1.6
Medication: Amlodipine 0.5 0.7 2.1 -0.4 0.1 0.7 0.0 1.4 1.2
Medication: Ventolin 100micrograms inhaler 0.1 0.2 0.4 0.2 -0.2 -0.6 -0.4 -0.6 0.1
Birth weight 0.8 1.6 5.7 -0.4 -1.0 1.7 2.4 -0.1 0.4
Chronic bronchitis/emphysema (mother) 1.6 1.9 3.5 1.8 1.9 -1.2 0.2 1.8 -0.0
High blood pressure (siblings) 0.9 1.2 3.5 -0.5 -1.1 0.9 1.1 0.6 1.9
Forced vital capacity (FVC), Best measure 1.3 4.6 13.3 -2.0 -2.0 3.6 2.1 -1.4 -0.2
Body fat percentage 1.1 4.4 9.5 3.0 2.3 -3.1 -0.6 1.4 0.5
Leg fat percentage (right) 1.1 4.2 8.9 2.9 2.4 -3.0 -0.6 1.1 0.4
Arm fat-free mass (right) 2.3 11.8 18.5 -1.7 -4.1 4.1 3.9 -1.1 4.3
Exposure to tobacco smoke outside home 1.0 1.3 2.7 0.9 1.1 -1.0 -1.6 1.3 0.6
Comparative body size at age 10 1.1 3.1 8.1 2.6 1.0 -1.1 -0.4 2.9 1.2
Number of full brothers 1.0 1.2 2.8 -1.5 -1.3 1.7 0.7 -0.4 0.2
Worry too long after embarrassment 1.8 3.0 7.0 1.4 2.6 -1.9 -1.7 1.6 -0.3
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.6 1.2 0.7 0.7 -0.3 0.5 0.9 1.1
Wheeze or whistling in the chest in last year 0.4 0.6 2.1 -1.4 -0.8 0.3 -0.5 -0.8 0.3
Number of children fathered 0.1 0.1 0.4 -0.2 0.4 0.2 0.1 0.2 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.9 1.1 3.6 -1.9 -0.2 0.9 0.8 -0.9 -0.6
Age at first live birth 1.5 2.7 9.5 3.1 0.7 1.8 -0.7 0.8 1.2
Pulse wave peak to peak time 1.4 1.6 3.9 1.3 2.0 -0.3 -1.4 0.7 -1.1
Health satisfaction 0.1 0.2 0.7 0.2 0.4 -0.2 -0.3 0.9 0.2
Shortness of breath walking on level ground 0.3 0.4 0.8 0.3 0.5 -0.6 -0.7 -0.9 -0.5
Qualifications: College or University degree 0.1 0.3 0.8 0.7 0.9 0.1 -0.4 -0.1 -0.3
Eye problems/disorders: None of the above 0.4 0.5 1.2 -1.1 -0.3 0.7 0.2 0.0 1.0
Mouth/teeth dental problems: Loose teeth 1.3 1.5 4.0 0.3 2.0 -1.6 -0.7 1.1 -0.8
Emphysema/chronic bronchitis 0.2 0.3 0.5 -0.5 -0.7 0.6 -0.4 -0.3 -0.5
Medication for pain relief, constipation, heartburn 2.5 4.2 9.4 1.9 1.9 -2.6 -3.1 1.0 -1.1
Neck or shoulder pain in last month 0.6 0.9 2.1 -1.0 -0.9 0.8 1.5 0.1 1.0
Medication: Blood pressure 0.2 0.3 1.0 0.6 -0.3 1.0 -0.3 0.7 -0.2
Angina (self-reported) 0.9 1.2 2.2 -1.5 -1.0 0.2 1.2 -1.4 -0.8
Migraine (self-reported) 5.6 6.9 20.5 -1.6 -2.5 2.7 4.5 -0.3 2.2
Medication: Ibuprofen 4.4 5.2 9.9 -3.1 -2.0 2.0 2.6 -2.6 -0.1
Medication: Allopurinol 0.5 0.6 2.9 -0.2 -0.6 1.7 -0.4 0.2 0.5
Medication: Omeprazole 0.2 0.2 0.5 -0.6 -0.7 0.0 0.5 0.3 -0.3
Medication: Seretide 50 evohaler 0.5 0.5 1.2 1.0 -0.3 -0.9 -1.1 -0.2 0.2
Mean time to correctly identify matches 1.4 2.7 5.4 -0.1 0.6 -2.3 -2.2 0.5 -2.3
Heart disease (mother) 0.6 0.7 2.4 -0.7 -0.4 -1.6 -0.1 -1.2 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.2 0.2 0.5 0.7 0.4 0.4 -0.2 -0.7 -0.1
Whole body fat mass 0.4 1.7 3.7 1.9 0.5 -1.2 0.9 0.9 1.8
Leg fat mass (right) 0.4 1.7 4.0 2.0 0.5 -1.0 0.7 0.9 1.9
Arm predicted mass (right) 2.5 12.8 20.6 -1.5 -4.3 4.3 4.0 -1.0 4.5
Pulse rate, automated reading 0.1 0.4 0.9 0.8 0.9 -0.2 0.4 -0.9 -0.2
Alcohol intake frequency. 0.8 1.8 4.1 -1.0 -2.0 1.0 1.9 -0.9 0.7
Comparative height size at age 10 0.7 3.8 9.9 -2.5 -3.1 2.2 0.5 -1.0 0.6
Number of full sisters 0.4 0.5 1.4 -0.3 -1.2 0.3 -0.2 0.3 1.0
Suffer from ‘nerves’ 1.5 2.3 6.2 2.5 1.6 -0.5 -1.8 1.2 -0.4
Overall health rating 1.4 3.1 6.6 2.1 1.1 -2.6 0.0 2.1 1.4
Chest pain or discomfort 0.2 0.2 0.7 -0.8 -0.4 -0.1 0.6 0.5 0.0
Had major operations 0.0 0.0 0.1 -0.1 -0.1 -0.2 0.3 0.4 0.0
Age at last live birth 1.9 2.7 9.9 3.1 1.1 1.4 -1.5 0.9 0.6
Family relationship satisfaction 0.6 0.8 3.8 2.0 0.3 -0.2 0.7 -0.3 -0.2
Leg pain on walking 0.9 1.1 2.0 -1.1 -1.2 0.7 1.4 -0.4 1.1
Qualifications: NVQ or HND or HNC or equivalent 1.0 1.2 2.7 -1.6 -1.4 0.6 1.1 0.4 0.8
Commuting to job workplace: Car/motor vehicle 0.7 0.9 2.5 -0.5 -0.3 0.8 1.3 -0.3 1.6
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.3 -0.1 0.4 0.2 0.4 0.5 0.2
Medication: Aspirin 1.0 1.3 4.0 0.6 0.3 1.1 0.1 1.4 2.0
Supplements: Vitamin C 1.2 1.4 3.8 -0.9 0.2 -1.3 -1.3 -0.7 -1.9
Knee pain experienced in last month 0.3 0.4 0.8 0.3 -0.1 -0.6 0.7 0.9 0.7
Hypertension (Self-reported) 0.2 0.5 1.4 1.2 0.1 0.0 -0.8 0.8 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.3 0.8 -0.1 0.4 -0.4 -0.1 -0.6 -0.9
Illnesses of father: Heart disease 0.9 1.3 3.6 -1.9 -0.8 -0.9 -0.1 -1.6 -0.7
Illnesses of siblings: Diabetes 0.1 0.2 0.3 -0.2 0.5 -0.6 -0.5 -0.1 -0.3
Smoking status: Previous 1.0 1.5 2.9 -1.3 0.4 -1.1 -1.5 -1.7 -1.0
Forced expiratory volume in 1-second (FEV1), predicted 1.0 2.2 5.2 -0.4 -1.9 2.3 1.4 -0.4 1.2
Whole body fat-free mass 2.5 14.4 25.0 -2.3 -5.0 4.3 4.2 -1.4 4.2
Leg fat-free mass (right) 1.8 9.9 16.2 -1.5 -4.0 3.5 3.5 -0.8 4.0
Arm fat percentage (left) 0.7 3.0 7.0 2.6 1.4 -2.5 0.4 1.3 1.0
Average weekly red wine intake 0.9 1.4 3.2 0.2 1.8 -1.1 -1.8 0.8 -0.0
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.2 0.4 -0.8 0.1 0.4 1.1 0.9
Mood swings 1.0 1.8 5.6 2.4 0.9 0.4 -1.3 1.3 0.9
Loneliness, isolation 0.6 0.9 2.3 0.8 -1.5 1.2 0.9 0.3 0.4
Long-standing illness, disability or infirmity 0.2 0.4 1.5 0.5 1.2 -0.3 -0.5 0.2 -0.0
Ever had bowel cancer screening 1.0 1.1 2.6 -0.1 0.7 -1.3 -1.6 0.6 -1.3
Diabetes diagnosed by doctor 1.4 2.3 4.1 1.4 1.0 -1.0 -2.0 1.9 1.6
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.3 -0.6 -0.8 1.1 -0.4 -0.5 1.0
Friendships satisfaction 0.3 0.3 1.1 -0.2 -0.5 1.1 0.6 0.4 0.3
Qualifications: nursing, teaching 0.9 1.5 3.5 0.2 -0.2 1.3 0.7 1.7 1.9
Commuting to job workplace: Walk 1.0 1.1 3.8 0.2 0.1 -1.9 -0.8 0.2 -1.3
Eye problems/disorders: Cataract 0.1 0.1 0.3 -0.4 0.1 0.4 0.4 -0.6 0.2
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 2.3 -1.5 -0.1 -0.7 0.8 -0.5 -1.1
Medication for cholesterol 0.3 0.5 1.3 0.5 0.2 -0.8 -0.8 0.2 -1.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.9 1.1 4.5 -0.3 0.6 -1.1 -0.1 -0.2 -2.1
Back pain experienced in last month 1.0 1.5 3.0 -1.7 -1.7 0.1 0.8 -1.4 0.8
Mineral and other dietary supplements 0.4 0.5 1.2 0.1 -0.6 1.1 -0.0 0.7 0.9
Breast cancer (self-reported) 1.0 1.2 2.2 -0.5 -1.1 0.7 1.4 1.5 1.1
Asthma (self-reported) 0.2 0.4 1.0 -0.1 -0.3 -0.8 -0.7 0.2 1.0
Osteoporosis (self-reported) 0.7 0.9 2.0 -1.4 -0.0 -0.6 -1.4 0.2 -1.1
Osteoarthritis (self-reported) 1.1 1.5 3.5 -0.9 -1.0 -0.6 1.9 -1.6 0.7
Medication: Aspirin 0.7 0.9 2.2 0.6 0.7 1.0 -0.4 1.1 1.5
Medication: Gliclazide 0.7 0.8 2.1 0.1 1.1 -0.6 -1.4 0.6 -0.8
Illnesses of father: None of the above (group 1) 1.9 2.3 6.6 2.6 0.9 -0.7 -0.6 2.3 0.4
Smoking status: Current 1.9 3.0 6.9 -0.3 -2.6 2.4 1.5 -1.3 1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 3.5 -0.6 0.3 1.9 1.1 0.3 1.1
Whole body water mass 2.5 14.4 24.9 -2.3 -5.0 4.3 4.2 -1.4 4.2
Leg predicted mass (right) 1.9 10.1 16.6 -1.5 -4.1 3.5 3.5 -0.7 4.0
Arm fat mass (left) 0.5 2.0 6.1 1.5 -0.5 -0.3 1.7 0.6 2.5
Number of self-reported non-cancer illnesses 0.4 0.7 1.9 -1.4 -1.1 -0.2 0.6 -0.2 0.9
Average weekly champagne plus white wine intake 0.7 1.0 2.6 1.1 0.6 -0.6 -1.6 0.7 -0.9
Miserableness 0.2 0.4 1.1 0.3 -0.5 1.1 -0.2 0.3 0.7
Guilty feelings 1.1 1.6 3.5 -0.8 1.4 -1.0 -1.6 -0.4 -1.9
Wears glasses or contact lenses 1.5 1.7 6.4 1.0 0.9 -2.5 -1.2 -0.2 -0.8
Ever taken oral contraceptive pill 0.3 0.4 1.6 0.1 0.1 -0.4 -1.3 0.2 -0.6
Hearing aid user 0.2 0.2 1.1 0.1 -0.1 -0.1 1.1 0.4 -0.3
Mother’s age at death 0.7 0.9 2.1 0.1 1.4 -0.6 -1.5 1.1 0.1
Financial situation satisfaction 0.8 0.9 2.6 0.8 1.6 -1.2 0.2 1.0 -0.1
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.1 -1.1 -1.1 1.5 0.5 -0.6 0.5
Commuting to job workplace: Public transport 1.2 1.4 3.8 0.7 1.5 -0.2 -1.9 0.2 -1.4
Eye problems/disorders: Glaucoma 0.6 0.7 1.2 0.8 -0.7 -1.0 0.6 -0.7 -1.1
Medication: Blood pressure 0.3 0.6 3.3 -0.0 0.3 0.1 -0.4 0.2 1.8
Pain type(s) experienced in last month: Hip pain 0.3 0.4 0.8 -0.6 -0.7 -0.1 0.9 -0.3 0.6
Supplements: Fish oil (including cod liver oil) 0.8 1.0 2.9 -0.6 -0.2 -0.5 0.8 -1.3 -1.7
High cholesterol (Self-reported) 0.7 1.2 3.8 1.9 0.5 -0.1 -1.7 0.3 0.3
Medication: Bendroflumethiazide 0.6 0.8 2.2 0.3 0.8 -0.8 -1.0 1.5 0.6
Medication: Paracetamol 1.4 2.2 4.6 -1.7 -1.1 1.1 2.1 -1.8 -0.6
Medication: Lisinopril 0.2 0.3 1.1 -0.0 -0.1 -0.1 -0.5 0.4 1.1
Medication: Atorvastatin 0.6 0.7 1.2 -0.9 -1.0 -0.3 0.1 -1.0 1.1
Illnesses of father: High blood pressure 2.0 2.5 5.6 -1.6 -2.4 1.8 1.1 -0.3 1.5
Alcohol drinker status: Never 0.3 0.4 0.8 -0.8 -0.4 -0.2 0.7 -0.9 -0.1
Ever smoked 0.6 1.1 1.7 -1.1 -1.1 1.1 -1.1 -1.3 0.5
Basal metabolic rate 2.0 10.9 18.4 -1.7 -4.3 3.6 3.9 -1.1 3.9
Leg fat percentage (left) 1.0 3.7 7.9 2.8 2.3 -2.8 -0.2 1.0 0.7
Arm fat-free mass (left) 2.3 11.7 18.2 -1.7 -4.2 3.8 3.9 -1.4 4.3
Number of operations (self-reported) 0.4 0.6 1.9 -1.4 -1.2 -0.3 -0.3 0.1 0.3
Average weekly beer plus cider intake 0.4 0.6 1.1 -0.7 0.4 -0.9 -0.5 -1.1 -0.6
Irritability 1.4 2.4 6.4 2.5 1.1 -0.0 -1.0 1.8 1.6
Risk taking 0.3 0.5 0.8 -0.9 0.7 -0.6 -0.9 -0.5 -0.5
Ever had prostate specific antigen (PSA) test 1.8 2.1 5.4 -1.7 -2.3 1.4 1.1 -0.5 0.9
Fractured/broken bones in last 5 years 0.2 0.3 0.8 -0.4 -0.1 -0.7 -0.9 0.0 0.5
Age started oral contraceptive pill 0.5 0.7 1.5 -0.0 -0.2 1.1 -1.0 0.5 1.2
Diastolic blood pressure, automated reading 0.4 1.1 3.9 -0.1 -0.5 0.7 2.0 -0.8 1.2
Ever depressed for a whole week 0.4 0.4 1.3 0.6 0.7 1.1 -0.3 0.1 -0.7
Unable to work because of sickness or disability 0.4 0.5 1.6 1.3 -0.1 -0.9 -0.6 0.2 -0.4
Commuting to job workplace: Cycle 1.4 1.6 2.8 1.3 1.1 -1.7 -1.5 0.8 -1.1
Myopia 0.7 1.1 3.0 1.0 0.6 -0.7 -1.7 0.9 0.7
Vascular/heart problems diagnosed by doctor 0.2 0.5 0.9 -1.0 -0.0 -0.2 0.9 -0.6 -0.8
Cholesterol lowering medication 0.9 1.3 5.6 0.7 -0.1 0.3 0.1 1.2 2.4
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.4 0.2 0.4 -0.6 -0.5 0.3 -0.6
Pain experienced in last month 0.2 0.4 0.9 0.9 0.9 0.1 -0.6 0.1 -0.7
Supplements: Calcium 1.1 1.2 2.5 -1.6 -1.0 -1.2 -0.4 -1.3 -0.4
Basal cell carcinoma (self-reported) 2.0 2.4 6.2 2.1 1.2 -2.5 -0.1 1.5 -0.3
Heart attack/myocardial infarction (self-reported) 0.4 0.5 1.4 0.9 0.0 0.4 -1.2 -0.2 0.7
Deep venous thrombosis (DVT) (self-reported) 1.3 1.7 4.6 -0.8 -1.4 2.1 1.4 -0.0 0.8
Heart disease (siblings) 0.4 0.5 2.3 -1.5 -0.7 0.2 -0.3 -0.2 -0.1
Alcohol drinker status: Previous 0.5 0.5 1.6 0.1 -1.3 0.8 0.4 0.0 0.8
Pack years of smoking 0.6 0.9 3.3 0.4 -0.6 0.1 -0.0 1.2 1.8
Impedance of whole body 3.3 17.0 30.6 2.5 4.6 -4.5 -5.5 1.8 -4.4
Leg fat mass (left) 0.5 1.8 4.6 2.0 0.4 -0.8 0.9 0.8 2.1
Arm predicted mass (left) 2.5 12.6 20.0 -1.6 -4.3 4.0 4.1 -1.3 4.5