Best TWAS P=2.02e-22 · Best GWAS P=2.87e-24 conditioned to 0.129
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cerebellar Hemisphere | DCST2 | 0.45 | 0.10 | lasso | 6 | 0.16 | 6.6e-05 | 3.83 | -7.8 | 9.5e-15 | 0.14 | 0.23 | 0.10 | FALSE |
| 2 | GTEx | Brain Nucleus accumbens basal ganglia | DCST2 | 0.28 | 0.04 | lasso | 5 | 0.13 | 2.0e-04 | -9.32 | -7.9 | 3.2e-15 | 0.19 | 0.13 | 0.21 | FALSE |
| 3 | GTEx | Esophagus Mucosa | MUC1 | 0.17 | 0.20 | lasso | 4 | 0.18 | 5.6e-12 | 6.06 | 5.4 | 5.8e-08 | -0.28 | 1.00 | 0.00 | FALSE |
| 4 | GTEx | Skin Sun Exposed Lower leg | ADAM15 | 0.14 | 0.09 | lasso | 4 | 0.08 | 6.1e-07 | -9.32 | 9.2 | 2.2e-20 | -0.08 | 0.72 | 0.25 | FALSE |
| 5 | GTEx | Thyroid | DCST2 | 0.16 | 0.12 | lasso | 2 | 0.11 | 6.4e-09 | 3.83 | -5.2 | 1.5e-07 | 0.14 | 0.99 | 0.00 | FALSE |
| 6 | GTEx | Whole Blood | C1orf43 | 0.10 | 0.00 | enet | 37 | 0.00 | 2.8e-01 | 3.51 | 5.1 | 2.9e-07 | -0.05 | 0.01 | 0.73 | FALSE |
| 7 | YFS | Blood | GBA | 0.04 | 0.01 | bslmm | 321 | 0.02 | 3.9e-08 | -3.96 | -5.2 | 1.9e-07 | 0.38 | 0.98 | 0.00 | FALSE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | ADAM15 | 0.15 | 0.02 | blup | 49 | 0.08 | 1.4e-05 | -10.14 | 7.2 | 4.2e-13 | -0.29 | 0.00 | 0.91 | FALSE |
| 9 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | MUC1 | 0.04 | 0.01 | enet | 4 | 0.02 | 1.3e-03 | 6.06 | 5.5 | 3.6e-08 | -0.18 | 0.04 | 0.03 | TRUE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | THBS3 | 0.04 | 0.01 | blup | 25 | 0.03 | 3.1e-04 | -1.83 | -5.2 | 1.5e-07 | 0.64 | 0.05 | 0.53 | FALSE |
| 11 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | ADAM15 | 0.09 | 0.00 | blup | 49 | 0.02 | 3.6e-02 | 3.63 | 7.5 | 4.3e-14 | -0.24 | 0.01 | 0.12 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | THBS3 | 0.04 | 0.02 | enet | 8 | 0.01 | 4.5e-02 | -1.83 | -5.7 | 1.5e-08 | 0.51 | 0.02 | 0.32 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | ADAM15 | 0.07 | 0.00 | enet | 12 | 0.04 | 6.1e-05 | -10.14 | 5.2 | 2.3e-07 | -0.19 | 0.00 | 0.90 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ZBTB7B | 0.05 | 0.06 | lasso | 2 | 0.05 | 1.8e-06 | -9.32 | 9.3 | 8.7e-21 | -0.07 | 0.00 | 1.00 | TRUE |
| 15 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | AQP10 | 0.12 | 0.01 | blup | 37 | 0.04 | 7.1e-03 | 3.13 | -5.3 | 1.0e-07 | -0.02 | 0.00 | 0.41 | TRUE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | GBA | 0.05 | 0.01 | lasso | 2 | 0.01 | 2.3e-02 | -10.16 | 9.7 | 2.0e-22 | -0.93 | 0.00 | 0.87 | TRUE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | THBS3 | 0.14 | 0.03 | enet | 16 | 0.08 | 3.8e-08 | 0.28 | -5.4 | 8.0e-08 | 0.69 | 0.00 | 0.99 | FALSE |