Best TWAS P=3.87e-14 · Best GWAS P=1.37e-12 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CEP250 | 0.02 | 0.00 | blup | 344 | 0.00 | 1.0e-01 | -3.7 | 5.1 | 2.8e-07 | 0.11 | 0.25 | 0.05 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | EDEM2 | 0.09 | 0.09 | enet | 12 | 0.09 | 5.8e-11 | -4.4 | 6.1 | 1.2e-09 | 0.27 | 0.96 | 0.04 | FALSE |
3 | GTEx | Adrenal Gland | NCOA6 | 0.10 | 0.08 | lasso | 14 | 0.05 | 7.7e-03 | 5.1 | 5.7 | 1.3e-08 | 0.03 | 0.18 | 0.38 | FALSE |
4 | GTEx | Artery Aorta | MYH7B | 0.22 | 0.08 | lasso | 6 | 0.09 | 1.3e-05 | -5.3 | -5.7 | 1.6e-08 | -0.23 | 0.50 | 0.48 | FALSE |
5 | GTEx | Artery Aorta | EDEM2 | 0.13 | 0.08 | enet | 10 | 0.07 | 6.3e-05 | -4.8 | 5.3 | 1.5e-07 | 0.30 | 0.52 | 0.42 | FALSE |
6 | GTEx | Artery Aorta | GGT7 | 0.06 | 0.00 | enet | 7 | 0.02 | 1.9e-02 | 5.6 | -7.6 | 3.9e-14 | -0.38 | 0.10 | 0.60 | TRUE |
7 | GTEx | Artery Tibial | MYH7B | 0.14 | 0.10 | lasso | 10 | 0.12 | 2.9e-09 | -5.2 | -5.4 | 8.5e-08 | -0.28 | 0.47 | 0.53 | FALSE |
8 | GTEx | Brain Cerebellar Hemisphere | MYH7B | 0.18 | 0.10 | lasso | 5 | 0.08 | 3.7e-03 | -5.3 | -5.2 | 2.3e-07 | -0.32 | 0.39 | 0.22 | TRUE |
9 | GTEx | Brain Cerebellum | MYH7B | 0.26 | 0.30 | lasso | 4 | 0.26 | 2.2e-08 | -5.3 | -5.5 | 3.2e-08 | -0.33 | 0.46 | 0.52 | FALSE |
10 | GTEx | Brain Hypothalamus | MAP1LC3A | 0.19 | 0.05 | lasso | 11 | 0.05 | 2.2e-02 | -4.7 | -5.3 | 1.1e-07 | -0.43 | 0.14 | 0.10 | FALSE |
11 | GTEx | Brain Hypothalamus | CEP250 | 0.18 | -0.01 | lasso | 9 | 0.00 | 3.4e-01 | -4.4 | 5.7 | 1.4e-08 | 0.06 | 0.11 | 0.15 | TRUE |
12 | GTEx | Brain Nucleus accumbens basal ganglia | EDEM2 | 0.17 | 0.00 | lasso | 4 | 0.00 | 2.7e-01 | -4.9 | 5.6 | 1.8e-08 | 0.32 | 0.10 | 0.15 | FALSE |
13 | GTEx | Breast Mammary Tissue | ITCH | 0.09 | 0.04 | enet | 28 | 0.09 | 2.5e-05 | -4.2 | 6.4 | 1.9e-10 | 0.74 | 0.21 | 0.76 | FALSE |
14 | GTEx | Breast Mammary Tissue (Female) | ITCH | 0.09 | 0.02 | enet | 16 | 0.06 | 8.2e-03 | 6.7 | 5.2 | 1.9e-07 | 0.78 | 0.08 | 0.61 | FALSE |
15 | GTEx | Cells EBV-transformed lymphocytes | PHF20 | 0.30 | -0.01 | enet | 13 | 0.04 | 2.3e-02 | -1.7 | 5.5 | 3.6e-08 | 0.12 | 0.06 | 0.05 | FALSE |
16 | GTEx | Cells EBV-transformed lymphocytes | NCOA6 | 0.11 | 0.06 | enet | 15 | 0.06 | 3.9e-03 | -5.0 | 5.8 | 5.7e-09 | 0.44 | 0.20 | 0.24 | FALSE |
17 | GTEx | Cells Transformed fibroblasts | EDEM2 | 0.08 | 0.02 | lasso | 5 | 0.03 | 1.8e-03 | -5.3 | 5.8 | 6.7e-09 | 0.22 | 0.37 | 0.25 | TRUE |
18 | GTEx | Cells Transformed fibroblasts | TRPC4AP | 0.06 | 0.01 | lasso | 2 | 0.01 | 4.2e-02 | 3.4 | 5.4 | 8.2e-08 | 0.15 | 0.12 | 0.35 | TRUE |
19 | GTEx | Cells Transformed fibroblasts | NCOA6 | 0.09 | 0.12 | enet | 25 | 0.09 | 1.5e-07 | 5.5 | 5.5 | 4.8e-08 | 0.06 | 0.24 | 0.76 | FALSE |
20 | GTEx | Colon Transverse | MAP1LC3A | 0.15 | 0.14 | lasso | 3 | 0.09 | 3.2e-05 | -4.1 | -5.3 | 1.3e-07 | -0.56 | 0.88 | 0.10 | FALSE |
21 | GTEx | Esophagus Gastroesophageal Junction | ITCH | 0.11 | 0.03 | lasso | 4 | 0.04 | 9.9e-03 | 5.5 | 5.7 | 1.3e-08 | 0.13 | 0.33 | 0.06 | FALSE |
22 | GTEx | Esophagus Muscularis | CEP250 | 0.13 | 0.04 | lasso | 6 | 0.03 | 1.1e-02 | -4.2 | 5.3 | 1.4e-07 | 0.04 | 0.36 | 0.06 | FALSE |
23 | GTEx | Nerve Tibial | MYH7B | 0.21 | 0.12 | lasso | 8 | 0.12 | 9.7e-09 | -5.3 | -5.2 | 1.8e-07 | -0.28 | 0.56 | 0.44 | FALSE |
24 | GTEx | Stomach | MAP1LC3A | 0.10 | 0.04 | enet | 10 | 0.05 | 1.3e-03 | 3.9 | -5.6 | 2.0e-08 | -0.51 | 0.26 | 0.27 | FALSE |
25 | GTEx | Testis | LINC00657 | 0.08 | 0.05 | enet | 15 | 0.05 | 3.0e-03 | -5.0 | 5.4 | 5.1e-08 | 0.04 | 0.64 | 0.03 | TRUE |
26 | GTEx | Thyroid | TP53INP2 | 0.09 | 0.05 | lasso | 7 | 0.04 | 3.7e-04 | 5.5 | -5.9 | 3.0e-09 | -0.10 | 0.09 | 0.90 | TRUE |
27 | GTEx | Thyroid | MYH7B | 0.06 | 0.03 | enet | 15 | 0.06 | 3.6e-05 | -5.0 | -6.1 | 1.1e-09 | -0.37 | 0.70 | 0.19 | FALSE |
28 | METSIM | Adipose | TP53INP2 | 0.05 | 0.03 | lasso | 3 | 0.04 | 1.3e-06 | 5.2 | -5.4 | 8.4e-08 | -0.07 | 0.14 | 0.86 | FALSE |
29 | METSIM | Adipose | TRPC4AP | 0.04 | 0.03 | lasso | 5 | 0.04 | 1.1e-06 | -5.3 | 5.4 | 7.7e-08 | 0.29 | 0.50 | 0.49 | FALSE |
30 | ROSMAP | Brain Pre-frontal Cortex | SPAG4 | 0.05 | 0.04 | enet | 8 | 0.04 | 5.7e-06 | -4.4 | 5.5 | 4.6e-08 | -0.02 | 0.86 | 0.12 | FALSE |
31 | ROSMAP | Brain Pre-frontal Cortex | FER1L4 | 0.04 | 0.04 | blup | 309 | 0.03 | 4.9e-05 | -4.6 | 5.3 | 9.9e-08 | 0.01 | 0.86 | 0.05 | FALSE |
32 | ROSMAP | Brain Pre-frontal Cortex | RALY | 0.09 | 0.16 | lasso | 7 | 0.15 | 2.7e-18 | 6.7 | 6.6 | 5.4e-11 | 0.83 | 0.14 | 0.86 | TRUE |
33 | ROSMAP | Brain Pre-frontal Cortex | ERGIC3 | 0.08 | 0.08 | lasso | 6 | 0.08 | 2.6e-10 | -4.8 | -5.4 | 5.5e-08 | -0.04 | 0.91 | 0.09 | FALSE |
34 | YFS | Blood | TP53INP2 | 0.02 | 0.02 | lasso | 15 | 0.01 | 1.3e-05 | 5.5 | -5.7 | 1.5e-08 | -0.09 | 0.13 | 0.86 | FALSE |
35 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CPNE1 | 0.34 | 0.47 | enet | 11 | 0.47 | 8.8e-111 | -4.6 | 5.1 | 3.0e-07 | -0.01 | 0.49 | 0.50 | FALSE |
36 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ERGIC3 | 0.01 | 0.00 | blup | 39 | 0.01 | 2.3e-02 | -4.8 | 5.1 | 3.0e-07 | 0.04 | 0.00 | 0.54 | FALSE |
37 | The Cancer Genome Atlas | Colon Adenocarcinoma | NCOA6 | 0.06 | 0.03 | lasso | 1 | 0.02 | 2.0e-02 | 5.5 | 5.5 | 3.5e-08 | 0.08 | 0.02 | 0.79 | FALSE |
38 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TRPC4AP | 0.05 | 0.03 | enet | 10 | 0.04 | 7.1e-05 | -4.8 | 5.2 | 2.2e-07 | 0.18 | 0.02 | 0.88 | FALSE |
39 | The Cancer Genome Atlas | Brain Lower Grade Glioma | EDEM2 | 0.07 | 0.02 | blup | 102 | 0.04 | 2.1e-05 | -3.3 | 5.3 | 1.1e-07 | 0.24 | 0.77 | 0.03 | FALSE |
40 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NCOA6 | 0.04 | 0.02 | blup | 65 | 0.04 | 6.1e-05 | 5.5 | 6.6 | 5.1e-11 | 0.22 | 0.02 | 0.95 | FALSE |
41 | The Cancer Genome Atlas | Thyroid Carcinoma | RALY | 0.05 | 0.04 | blup | 53 | 0.05 | 1.6e-05 | 6.5 | -6.5 | 1.1e-10 | -0.94 | 0.03 | 0.96 | FALSE |