Hub : Genes

ERGIC3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cortex	0.1480	0.0680	3.0e-03	-0.008	NA	-0.008	NA	0.002	6.4e-01	NA	6.0e-01	NA	2.8e-01
2	GTEx	Cells Transformed fibroblasts	0.2870	0.0670	2.6e-10	0.199	NA	0.196	NA	0.205	7.5e-15	NA	1.1e-14	NA	2.5e-15
3	GTEx	Nerve Tibial	0.0731	0.0399	3.3e-03	0.081	NA	0.046	NA	0.067	2.4e-06	NA	3.3e-04	NA	1.7e-05
4	GTEx	Uterus	0.5940	0.1410	2.0e-03	0.051	NA	0.082	NA	0.127	3.4e-02	NA	9.7e-03	NA	1.5e-03
5	NTR	Blood	0.0955	0.0310	6.5e-15	0.062	0.051	0.056	0.060	0.059	2.9e-19	4.5e-16	2.0e-17	1.6e-18	2.6e-18
6	ROSMAP	Brain Pre-frontal Cortex	0.0810	0.0295	1.0e-07	0.078	0.067	0.074	0.071	0.079	3.1e-10	5.2e-09	8.1e-10	1.8e-09	2.6e-10
7	TCGA	Breast Invasive Carcinoma	0.0145	0.0121	8.8e-03	0.005	0.005	0.003	NA	0.003	2.8e-02	2.3e-02	7.5e-02	NA	5.7e-02
8	TCGA	Colon Adenocarcinoma	0.0490	0.0330	2.6e-03	0.029	0.038	0.026	NA	0.025	8.5e-03	3.0e-03	1.2e-02	NA	1.4e-02
9	TCGA	Esophageal Carcinoma	0.4240	0.2010	2.4e-03	0.097	0.090	0.138	NA	0.068	5.4e-04	8.5e-04	3.8e-05	NA	3.4e-03
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.0881	0.0388	2.4e-09	0.100	0.073	0.082	NA	0.089	2.2e-11	1.4e-08	1.8e-09	NA	3.4e-10
11	TCGA	Lung Adenocarcinoma	0.0355	0.0204	1.4e-04	0.025	0.033	0.020	NA	0.022	5.1e-04	9.3e-05	1.9e-03	NA	1.1e-03
12	TCGA	Stomach Adenocarcinoma	0.0720	0.0520	4.9e-03	0.042	0.022	0.031	NA	0.024	5.2e-04	8.9e-03	2.6e-03	NA	6.9e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Bipolar Disorder (2018)	1.1	1.8	3.2	1.4	-1.8	1.8	0.8	-1.4	1.1	-1.4	-0.6	0.5	-1.7	-1.5	-1.3
Bipolar Disorder or Schizophrenia	0.3	0.8	2.5	1.1	-0.9	1.2	-0.7	-1.6	0.6	-0.5	-0.1	-0.4	-1.1	-0.7	-0.6
Depressed Affect (Nagel 2018)	0.4	0.8	6.4	-0.0	-0.2	0.4	-0.9	-0.1	0.8	-0.3	-0.4	-2.5	-0.9	-0.4	-0.8
Depression (Nagel 2018)	2.3	3.5	6.8	2.2	-1.2	1.7	-0.7	0.8	2.1	-1.8	-2.1	-2.6	-2.1	-1.8	-2.4
Intelligence (Savage-Jansen 2018)	3.2	9.8	21.2	3.0	-2.6	2.7	2.8	2.1	3.6	-3.3	-4.6	-1.6	-2.6	-3.1	-4.3
Neuroticism (Nagel 2018)	0.3	0.7	1.7	0.2	-0.7	0.6	-0.7	0.5	1.2	-1.0	-0.7	-1.1	-1.3	-1.0	-0.7
Schizophrenia (2018)	0.2	0.4	2.2	0.4	0.3	0.1	-1.5	-0.9	0.1	0.4	0.3	-0.9	-0.0	0.3	0.3
Schizophrenia vs Biploar Disorder	2.1	2.8	5.8	-2.1	1.7	-1.7	-2.4	-0.9	-1.2	1.7	1.8	0.5	1.1	1.5	2.4
Worry (Nagel 2018)	0.4	0.8	1.5	0.7	-0.7	0.6	-0.2	1.2	1.2	-1.1	-1.2	-0.4	-1.1	-1.0	-0.8
Alzheimer’s Disease (in mother)	0.4	0.4	1.1	-0.5	0.9	-0.8	-0.3	0.4	-1.1	0.6	0.6	-0.1	0.6	0.8	0.6
Alzheimer’s Disease (in father)	1.1	1.2	3.8	-1.4	0.7	-0.9	0.1	-2.0	-0.9	1.0	1.6	-0.2	1.0	1.0	0.8
Alzheimer’s Disease (including proxy)	0.5	0.8	2.0	-1.1	0.9	-0.8	-0.5	-1.0	-1.0	0.8	1.4	-0.5	0.5	0.9	0.6
Crohns Disease (2017)	0.0	0.1	0.3	0.5	-0.0	-0.0	-0.1	0.3	0.2	-0.2	0.0	0.5	0.2	-0.1	0.1
Irritable Bowel Disease (IBD)	1.0	2.3	4.2	2.0	-1.1	1.6	-2.0	-0.1	2.0	-1.7	-1.3	-0.9	-1.5	-1.6	-1.4
Ulcerative Colitis (UC)	1.6	3.1	7.1	2.1	-1.2	1.8	-2.7	-0.3	2.3	-1.8	-1.7	-1.0	-1.5	-1.7	-1.8
Major Depression (MDD)	0.3	0.4	2.4	-0.3	-0.4	0.3	0.2	-1.5	0.6	-0.0	0.9	-0.4	-0.6	-0.1	-0.1
Reaction Time	2.6	5.0	8.5	-2.2	2.1	-2.4	-0.4	-1.5	-2.9	2.8	2.7	1.4	2.0	2.6	2.4
Verbal and Numeric Reasoning (VNR)	2.5	5.9	10.5	2.5	-2.3	2.4	1.9	1.0	2.9	-2.7	-3.2	-0.9	-2.2	-2.6	-3.2
Breast Cancer	0.8	2.0	6.0	-1.0	1.0	-1.2	1.3	1.3	-2.1	1.1	0.6	1.2	2.5	1.4	1.2
Ovarian Cancer	1.1	1.5	3.1	-0.9	1.4	-1.2	-1.3	0.8	-1.7	1.0	0.9	1.0	1.8	1.3	0.9
Prostate Cancer	1.3	1.8	5.7	-2.4	1.4	-1.1	-0.5	-0.5	-1.1	1.6	1.8	0.2	1.1	1.7	1.3
Age at First Birth	0.2	0.3	2.1	0.1	0.1	-0.4	0.8	0.1	-0.2	-0.3	-0.2	1.5	-0.4	-0.5	0.6
Bipolar Disorder (2011)	0.7	0.7	3.5	0.5	1.1	-0.9	-0.3	1.9	-0.9	0.7	-0.3	-0.1	0.7	0.8	0.5
Body Mass Index (BMI) (2010)	0.2	0.2	0.8	-0.3	0.3	-0.6	0.1	0.1	-0.8	0.6	0.0	0.9	0.5	0.5	0.1
Coronary Artery Disease (CAD)	1.3	1.6	3.1	1.0	-0.9	1.0	-1.1	-1.1	1.7	-1.5	-1.1	-0.2	-1.8	-1.5	-1.4
Crohns Disease (2012)	0.5	0.7	1.9	1.4	-0.7	0.6	0.2	0.5	1.0	-1.0	-1.2	-0.7	-0.3	-0.8	-1.1
Mean Putamen Volume	0.5	0.6	6.0	0.3	-0.0	0.0	0.6	0.4	-0.3	-0.1	-0.3	2.4	-0.2	-0.2	0.3
Fasting Glucose	0.4	0.5	1.7	0.4	-0.2	0.1	1.3	1.3	-0.2	-0.4	-0.3	1.1	0.6	-0.2	-0.0
HbA1C	0.4	0.4	0.9	-0.9	0.4	-0.5	0.7	-0.3	-0.8	0.9	0.8	-0.4	0.0	0.7	0.8
HDL Cholesterol	2.4	4.0	6.9	-2.4	2.0	-1.9	-0.5	-0.2	-2.6	2.0	2.3	1.4	2.3	2.0	2.6
LDL Cholesterol	8.7	13.8	24.5	-4.7	3.9	-4.4	0.0	-0.0	-4.5	4.1	3.7	3.3	2.8	3.9	5.0
Lupus	0.7	1.1	5.3	-0.0	0.7	-1.0	0.3	2.3	-0.6	0.0	-0.8	1.8	1.3	0.2	0.7
Neuroticism (2016)	0.9	1.3	3.0	1.1	-1.7	1.2	0.9	-1.0	1.4	-1.3	-0.7	0.6	-0.7	-1.3	-1.2
Primary Biliary Cirrhosis	0.4	0.5	3.3	0.8	0.1	0.4	-1.8	0.4	0.5	-0.2	-0.5	-0.9	0.0	0.0	-0.8
Rheumatoid Arthritis	0.2	0.3	1.8	0.0	0.4	-0.1	-1.3	0.1	0.8	0.1	-0.0	0.5	-0.0	0.0	0.7
Schizophrenia (2014)	0.2	0.4	1.6	0.8	-0.3	0.5	-1.3	-0.7	0.4	-0.1	-0.1	-1.0	-0.4	-0.2	-0.3
Triglycerides	4.0	6.5	11.4	-2.3	3.0	-3.4	-1.0	0.9	-3.0	3.0	2.1	2.4	2.6	3.0	2.6
Type 2 Diabetes (T2D) (2012)	3.4	3.9	6.0	1.6	-2.2	1.8	2.4	0.5	2.1	-2.4	-2.4	0.1	-1.8	-2.4	-2.4
Ulcerative Colitis	3.8	5.5	9.1	3.0	-1.5	2.4	-2.8	-0.1	2.9	-2.5	-2.3	-1.9	-2.4	-2.2	-2.6
Blood Eosinophil Count	0.1	0.9	3.9	0.5	-0.4	0.7	-0.2	-0.3	0.7	0.3	-1.0	-2.0	-1.1	-0.2	-1.6
Blood Platelet Count	1.7	19.7	32.3	3.9	-4.6	5.0	2.3	-0.6	5.7	-5.2	-4.6	-1.9	-5.4	-5.3	-5.3
Blood Red Count	0.4	3.9	9.9	-1.5	1.6	-2.5	3.1	0.7	-2.7	2.4	0.9	-0.6	2.4	2.1	1.3
Blood White Count	0.1	0.8	4.4	0.8	-1.1	1.1	-0.0	-2.1	0.5	-0.2	-0.0	-0.7	-0.6	-0.5	-0.8
Heel T-Score	0.1	1.1	2.7	-1.5	0.5	-1.1	1.6	-0.7	-0.8	1.3	0.6	-1.3	-0.2	1.0	-0.4
BMI	0.4	2.5	8.0	1.1	-2.2	1.8	0.7	-2.8	1.8	-1.1	-0.5	0.1	-1.3	-1.4	-2.1
Height	22.0	423.1	1043.3	32.3	-17.9	19.0	0.6	13.9	22.2	-24.5	-28.7	-1.9	-15.9	-23.7	-20.6
Waist Hip Ratio (WHR)	0.9	4.2	16.5	-4.1	1.9	-1.8	0.0	-1.0	-1.0	2.4	2.7	-1.2	1.5	2.4	1.5
Systolic Blood Pressure	2.3	11.4	27.1	5.2	-3.3	3.3	0.7	0.7	3.3	-4.2	-4.1	-0.4	-3.3	-4.2	-3.7
Smoking Status	0.2	0.5	2.9	-0.4	-0.6	0.8	-0.3	-1.7	0.6	-0.5	0.6	-0.4	-0.3	-0.5	0.2
Allergy or Eczema	0.2	0.7	5.9	0.2	0.6	-0.6	0.5	2.4	-0.3	0.2	-0.5	0.1	0.7	0.4	0.0
Cardiovascular Disease	0.2	0.7	1.4	0.4	-1.1	1.1	0.5	-1.1	0.4	-0.6	-0.2	-1.1	-1.1	-0.8	-1.2
Hypothyroidism (self reported)	2.0	4.7	10.2	1.9	-2.5	2.9	-0.1	-3.2	2.5	-1.8	-0.3	-0.9	-3.1	-2.2	-1.8
Respiratory disease	2.7	6.1	12.0	2.7	-2.3	2.5	-0.1	-0.6	3.5	-3.0	-2.2	-2.1	-2.9	-3.0	-2.5
Type 2 Diabetes (T2D) (2018)	0.7	1.3	3.2	1.1	-0.9	1.2	0.8	1.2	1.3	-1.1	-1.8	-0.8	-0.8	-1.0	-1.5
Lung FEV1/FVC ratio	1.6	8.0	14.3	3.2	-2.4	2.7	-0.8	1.4	3.6	-3.6	-3.8	-1.4	-2.6	-3.5	-3.1
Lung FVC	6.1	31.0	76.6	-8.8	4.4	-4.4	-2.0	-5.2	-5.7	6.2	8.7	0.4	3.1	5.9	6.0
Neuroticism	0.9	2.1	3.5	1.1	-1.6	1.4	-0.0	-0.3	1.8	-1.6	-1.3	-1.4	-1.9	-1.7	-1.7
Chronotype (morning person)	1.3	3.1	6.8	2.6	-1.8	1.7	-0.2	0.5	2.2	-2.1	-1.9	0.4	-2.0	-2.2	-1.2
Hair Pigment	4.0	114.6	205.4	-14.3	8.0	-12.1	2.0	-2.1	-10.3	14.0	10.0	-13.4	10.5	12.7	9.9
Tanning	10.2	124.3	231.0	15.2	-8.8	12.9	-2.1	2.3	11.0	-14.8	-9.9	13.2	-10.9	-13.3	-9.9
Hand grip strength (left)	5.6	14.9	44.6	6.7	-3.4	3.1	0.6	3.3	3.4	-4.4	-5.6	1.4	-2.4	-4.5	-3.4
Number of treatments/medications taken	1.2	2.1	5.2	1.3	-1.3	1.6	-0.1	-2.3	1.8	-1.2	-0.1	-1.8	-1.6	-1.2	-1.6
Average weekly spirits intake	0.5	0.6	2.4	-0.4	0.2	-0.3	-1.5	-1.4	-0.5	0.5	1.0	0.7	0.1	0.4	0.9
Sensitivity / hurt feelings	1.6	2.7	6.8	-2.1	1.1	-1.1	-2.2	-1.6	-1.0	1.4	2.6	1.2	0.8	1.4	2.1
Frequency of depressed mood in last 2 weeks	2.4	3.4	14.2	1.5	-0.9	1.6	-1.8	-0.4	1.9	-1.4	-1.3	-3.8	-2.0	-1.3	-2.2
Hearing difficulty/problems: Yes	0.7	1.1	7.7	-0.9	0.2	-1.2	2.8	0.9	-0.4	0.4	0.3	0.2	0.6	0.4	1.0
Relative age of first facial hair	2.0	4.0	8.8	-2.8	2.1	-1.9	-1.2	-0.8	-1.4	2.3	3.0	-0.1	1.7	2.4	2.5
Other serious medical condition/disability diagnosed by doctor	1.3	1.7	8.7	-0.5	-0.2	0.4	-1.6	-2.9	0.6	0.7	1.7	-2.1	-0.8	0.5	0.2
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.9	0.5	-0.9	1.1	-0.5	-1.6	0.7	-0.4	0.4	-0.9	-1.7	-0.5	-1.1
Ever had hysterectomy (womb removed)	0.2	0.3	1.0	0.3	-0.5	0.3	0.8	-0.9	-0.1	-0.3	-0.0	1.0	-0.1	-0.4	-0.1
Systolic blood pressure, automated reading	1.3	3.8	9.1	3.0	-1.8	1.7	0.4	0.4	1.9	-2.5	-2.4	-1.0	-1.8	-2.5	-2.1
Eye problems/disorders: Diabetes related eye disease	1.5	1.6	4.0	1.2	-1.3	1.3	0.6	1.0	1.3	-1.6	-2.0	-0.3	-0.8	-1.5	-1.4
Angina	0.7	0.9	2.6	1.0	-1.0	1.1	-0.1	-0.4	1.3	-0.7	-0.4	-1.6	-0.5	-0.7	-1.1
Medication for hormone replacement therapy	0.2	0.3	1.4	0.0	-0.0	0.4	-1.0	-0.5	0.2	-0.2	0.4	0.1	-1.2	-0.2	-0.2
Vitamin and mineral supplements	1.7	2.2	4.7	-1.7	1.6	-1.7	1.0	1.0	-1.7	1.7	0.6	0.9	2.2	1.7	1.4
Supplements: Zinc	2.0	2.1	6.4	2.5	-1.0	1.3	-0.2	0.7	1.4	-1.8	-1.7	-0.8	-1.5	-1.8	-1.3
Medication: Co-codamol	1.4	1.6	3.9	0.4	-1.7	1.8	0.1	-2.0	1.1	-1.1	-0.2	-0.8	-1.5	-1.2	-1.5
Medication: Metformin	2.2	3.1	6.1	1.7	-2.0	2.0	0.9	0.5	1.9	-1.9	-2.5	-0.7	-1.6	-2.0	-2.2
Diabetes (father)	0.7	0.9	2.0	1.2	-1.0	0.9	1.0	0.0	0.9	-0.6	-1.1	1.4	-0.6	-0.8	-1.0
Diabetes (mother)	2.1	2.7	7.6	2.8	-1.6	1.6	-0.7	-0.8	1.8	-1.5	-1.6	-1.9	-0.8	-1.5	-2.1
Severe depression (siblings)	0.6	0.7	3.1	0.0	-0.9	0.5	0.9	-1.7	0.5	-0.5	0.2	1.5	-0.6	-0.6	-0.3
Pack years adult smoking proportion	1.2	1.8	2.9	1.7	-1.6	1.7	-1.1	-1.1	1.7	-1.3	-1.0	-0.8	-0.7	-1.3	-1.6
Impedance of leg (right)	6.0	29.2	61.7	-7.9	5.6	-5.8	0.1	-0.9	-6.6	6.4	6.2	0.1	5.1	6.5	5.5
Leg fat-free mass (left)	18.0	95.6	225.0	15.0	-9.4	9.5	0.7	4.4	11.0	-11.6	-12.9	-0.3	-8.1	-11.6	-10.0
Trunk fat percentage	0.1	0.5	2.9	0.5	-1.1	0.7	0.2	-1.7	0.4	0.1	-0.1	-0.3	0.1	-0.2	-0.9
Hand grip strength (right)	9.3	25.3	66.7	8.2	-4.4	4.2	0.8	3.8	4.9	-6.0	-7.3	1.6	-3.5	-6.0	-4.6
Townsend deprivation index at recruitment	0.8	1.2	5.7	-0.6	-1.2	1.4	-0.3	-2.4	1.1	-0.2	1.2	-0.2	-1.3	-0.4	-0.2
Current tobacco smoking	0.6	1.0	4.6	0.5	-0.7	0.9	-2.1	-1.8	0.9	-0.5	0.2	-0.9	-0.7	-0.6	-0.3
Average weekly fortified wine intake	0.6	0.7	2.4	-0.3	0.4	-0.9	0.2	0.7	-1.1	0.5	0.0	1.5	1.5	0.6	0.8
Maternal smoking around birth	0.7	1.0	4.1	-1.0	-0.5	0.6	-1.1	-2.0	1.0	0.0	0.7	-1.8	-0.5	0.0	-0.6
Fed-up feelings	1.1	1.9	11.4	0.4	-0.8	1.1	-1.1	-0.8	1.4	-0.7	-0.5	-3.4	-1.4	-0.7	-1.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.8	2.4	7.0	1.5	-1.4	1.6	-0.2	-0.5	1.7	-1.3	-1.2	-2.6	-1.6	-1.4	-1.9
Relative age voice broke	3.4	5.2	12.7	-3.6	2.3	-2.3	0.0	-0.5	-1.9	2.6	3.1	0.4	2.0	2.7	2.8
Taking other prescription medications	1.0	1.6	3.3	1.1	-1.4	1.6	0.1	-1.2	1.6	-1.1	-0.5	-1.8	-1.2	-1.1	-1.5
Age when periods started (menarche)	1.7	4.0	13.6	-2.4	2.7	-2.5	-0.4	3.7	-1.2	1.3	0.4	0.7	1.4	1.5	2.6
Bilateral oophorectomy (both ovaries removed)	0.4	0.4	1.7	0.4	-0.8	0.5	0.4	-1.3	0.7	-0.3	0.4	-0.9	-0.5	-0.3	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.9	5.9	-0.6	0.4	-1.0	2.4	0.2	-0.8	1.0	0.0	-0.4	0.4	0.9	-0.2
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.2	-0.9	1.1	-1.2	-0.2	0.1	-1.0	1.5	1.2	0.0	1.1	1.4	1.2
Qualifications: CSEs or equivalent	3.7	4.9	9.4	-2.3	1.9	-1.8	-2.2	-1.7	-2.4	2.5	3.1	0.3	2.1	2.6	2.4
Serious illness, injury or assault to yourself	0.4	0.5	1.8	0.2	-0.2	0.6	-0.6	-1.4	0.6	-0.1	0.8	-1.3	-0.4	0.0	-0.5
High blood pressure	1.6	4.4	8.0	1.9	-2.8	2.7	1.3	-2.2	2.2	-2.2	-0.8	-1.4	-2.2	-2.2	-2.3
Hayfever, allergic rhinitis or eczema	0.4	0.9	6.4	0.2	0.9	-0.9	-0.5	2.5	-0.7	0.3	-0.5	0.9	1.0	0.5	0.3
Multivitamins +/- minerals	1.1	1.4	3.1	1.8	-1.2	1.1	-0.5	-0.4	1.7	-1.4	-0.9	-0.1	-1.4	-1.4	-1.1
Stomach or abdominal pain in last month	0.5	0.7	2.4	-1.0	0.2	-0.0	-0.2	-1.5	-0.6	0.8	1.2	-1.1	-0.1	0.7	0.4
Supplements: Glucosamine	0.1	0.2	0.3	-0.4	-0.1	0.1	-0.4	-0.5	-0.5	-0.3	0.5	0.6	-0.6	-0.3	0.4
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	7.6	-1.0	-0.4	-0.0	0.7	-2.8	-0.3	0.3	1.7	1.5	-0.6	0.1	0.4
Medication: Atenolol	0.6	0.7	2.1	1.2	-0.0	0.1	-1.5	0.9	1.0	-0.8	-1.1	-0.9	-0.1	-0.7	-0.3
Medication: Levothyroxine sodium	1.7	2.9	5.8	1.9	-1.8	2.1	0.6	-1.8	2.1	-1.6	-0.6	-1.3	-2.4	-1.8	-1.6
Sitting height	25.5	181.1	449.4	21.2	-11.5	11.7	2.1	10.8	13.7	-15.8	-19.5	0.2	-10.2	-15.6	-13.0
Chronic bronchitis/emphysema (father)	2.2	2.6	4.2	-1.2	2.0	-1.6	-1.9	-0.8	-1.4	1.9	1.9	-1.2	1.5	2.0	1.3
High blood pressure (mother)	1.6	2.3	5.0	1.7	-1.8	1.4	1.7	-0.5	1.4	-1.8	-1.3	2.2	-0.5	-1.8	-0.8
Body mass index (BMI)	0.6	2.5	8.6	1.0	-2.1	2.0	0.3	-2.9	1.8	-1.0	-0.2	-0.5	-1.3	-1.2	-2.0
Impedance of leg (left)	5.4	26.3	57.1	-7.6	5.1	-5.3	0.3	-1.3	-6.2	6.1	6.1	-0.1	4.9	6.2	5.3
Leg predicted mass (left)	17.8	94.1	222.0	14.9	-9.3	9.4	0.6	4.4	10.9	-11.5	-12.8	-0.2	-8.1	-11.5	-9.9
Trunk fat mass	3.1	13.2	28.2	5.3	-4.2	4.0	0.7	-0.1	4.2	-4.0	-4.4	-0.7	-2.7	-4.2	-4.3
Waist circumference	3.2	11.7	20.1	4.2	-4.0	4.0	0.6	-0.7	4.5	-3.7	-3.6	-1.3	-2.9	-3.8	-4.3
Number of incorrect matches in round	2.5	4.2	7.9	-2.5	1.6	-1.7	0.6	-0.4	-2.7	2.3	2.3	2.8	1.5	2.1	2.4
Past tobacco smoking	0.2	0.4	1.8	1.3	0.1	-0.2	0.3	1.0	-0.1	-0.0	-1.1	0.2	0.3	-0.0	-0.7
Alcohol usually taken with meals	3.1	5.0	12.8	2.2	-1.4	1.3	1.5	3.2	1.3	-2.9	-3.6	0.8	-2.0	-2.8	-1.9
Nervous feelings	0.5	1.0	2.5	-0.4	-0.7	0.9	-1.6	-0.3	1.2	-0.9	-0.6	-1.3	-1.6	-0.9	-0.7
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	8.4	0.9	-1.5	1.9	-0.6	-2.0	1.7	-1.5	-0.6	-2.2	-2.9	-1.6	-2.2
Hearing difficulty/problems with background noise	0.1	0.2	1.3	-0.4	0.2	-0.3	0.4	1.1	-0.1	-0.1	-0.4	0.2	0.1	-0.1	0.4
Hair/balding pattern: Pattern 2	0.4	0.5	2.2	-1.5	0.2	-0.4	-0.3	-0.9	-0.5	0.7	0.9	0.2	0.2	0.5	0.6
Had menopause	2.9	3.6	6.5	2.4	-1.8	2.2	0.7	-0.3	2.5	-2.1	-1.8	-1.5	-1.9	-2.1	-2.2
Had other major operations	0.2	0.2	1.3	-0.2	-0.1	0.4	-0.7	-0.2	0.3	0.2	0.2	-1.1	0.1	0.2	0.2
Forced vital capacity (FVC)	2.1	8.2	15.9	4.0	-2.7	2.9	-0.6	1.7	2.8	-3.7	-3.8	0.5	-2.6	-3.7	-2.5
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	4.2	0.2	-0.2	-0.2	2.0	-0.2	-0.3	0.5	-0.2	0.1	-0.0	0.4	-0.6
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.5	0.9	-1.2	1.1	-0.1	-1.2	0.9	-0.7	-0.0	1.1	-0.6	-0.9	-0.6
Qualifications: None of the above	1.5	3.1	7.9	-2.4	1.2	-0.9	-2.0	-2.7	-1.0	1.7	2.8	-0.6	0.8	1.6	1.6
Financial difficulties in last 2 years	3.0	4.0	14.7	1.6	-1.3	1.9	-2.6	-1.4	2.0	-1.3	-0.7	-3.8	-2.0	-1.2	-2.2
Mouth/teeth dental problems	1.6	2.4	6.8	1.3	-1.8	1.2	2.6	0.5	1.5	-1.7	-2.0	0.5	-1.3	-1.9	-1.2
Heart attack	0.5	0.6	3.3	0.5	-1.1	0.8	1.8	-1.1	0.7	-0.4	0.2	-0.2	-0.2	-0.4	-0.4
Allergy	0.2	0.6	2.3	-1.1	0.2	-0.1	0.2	-1.5	-0.7	0.8	1.2	-0.2	-0.0	0.6	0.5
Pain all over the body in last month	0.9	0.9	6.5	0.4	0.1	0.4	-1.9	-0.5	0.5	0.2	0.3	-2.5	-0.2	0.2	-0.3
Diabetes (self-reported)	2.1	3.2	6.4	2.2	-1.5	1.9	0.8	0.9	2.0	-1.8	-2.5	-1.6	-1.2	-1.7	-2.5
Hayfever/allergic rhinitis (self-reported)	0.3	0.4	1.5	0.3	0.5	-0.7	-0.1	1.2	-0.0	0.2	-0.3	1.1	0.9	0.3	0.5
Medication: Ramipril	0.6	0.8	5.1	0.4	-0.1	-0.2	1.4	2.3	0.5	-0.1	-1.2	-0.2	0.6	-0.0	-0.6
Medication: Simvastatin	2.8	4.1	8.7	-1.4	2.2	-2.6	1.0	2.1	-2.5	2.1	0.9	1.5	2.9	2.1	2.0
Fluid intelligence score	3.9	8.1	13.5	3.1	-2.5	2.6	2.5	0.7	3.2	-3.3	-3.6	-1.6	-2.8	-3.2	-3.7
Illnesses of siblings	4.4	6.2	10.8	-2.1	3.3	-3.1	-1.5	2.6	-2.6	2.7	1.2	1.1	2.8	2.8	2.9
Neuroticism score	1.3	2.8	5.8	0.9	-1.6	1.7	-1.1	-0.7	2.3	-1.5	-1.0	-2.4	-2.1	-1.6	-2.0
Weight	10.9	53.5	119.7	10.9	-7.5	7.6	1.0	2.1	8.3	-8.5	-9.4	-1.0	-5.8	-8.6	-8.0
Impedance of arm (right)	4.1	19.3	33.7	-4.7	4.8	-5.1	-1.5	0.8	-5.8	5.6	4.3	0.0	4.6	5.5	4.7
Arm fat percentage (right)	0.4	1.4	8.9	-0.9	-0.4	0.3	-1.0	-3.0	-0.1	1.1	1.5	-1.4	0.1	0.8	-0.3
Trunk fat-free mass	23.7	136.0	309.8	17.6	-11.0	11.2	1.3	6.2	13.1	-14.0	-15.7	-1.0	-9.4	-13.9	-11.8
Hip circumference	7.1	30.4	65.0	8.1	-6.2	6.1	1.2	0.7	6.1	-6.4	-6.7	0.1	-4.5	-6.6	-6.0
Time employed in main current job	1.2	1.4	3.8	-0.8	1.6	-1.5	-0.0	0.7	-1.9	1.1	1.0	1.1	0.9	1.2	1.2
Alcohol intake versus 10 years previously	6.6	9.9	16.4	3.6	-3.3	3.8	-1.5	-0.7	4.0	-3.4	-2.8	-1.9	-3.7	-3.6	-3.6
Father’s age at death	0.8	1.1	7.8	0.5	-0.8	0.6	2.8	0.6	0.1	-0.9	-0.7	1.0	-0.7	-0.9	-0.3
Worrier / anxious feelings	0.8	1.6	3.2	1.1	-1.2	1.2	0.6	0.6	1.8	-1.5	-1.2	-1.3	-1.4	-1.3	-1.4
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	7.9	1.2	-1.3	1.7	-1.0	-1.0	1.6	-1.2	-0.7	-2.8	-2.7	-1.4	-1.8
Falls in the last year	0.4	0.5	5.0	0.1	0.2	0.1	-0.4	-0.3	0.4	-0.0	0.3	-2.2	-0.5	0.1	-0.5
Hair/balding pattern: Pattern 3	0.7	1.0	3.2	1.8	-0.2	0.4	1.2	1.0	0.5	-0.9	-1.5	-1.6	-0.0	-0.7	-0.7
Number of live births	0.8	1.1	7.1	-0.6	0.1	0.3	-1.1	-2.7	-0.3	0.9	1.7	-0.1	0.3	0.8	0.3
Forced expiratory volume in 1-second (FEV1)	2.6	8.8	15.7	3.7	-2.7	3.0	-0.8	1.5	3.3	-3.9	-4.0	-0.6	-2.9	-3.8	-2.9
Pulse rate	1.4	2.4	5.5	-1.7	0.7	-0.8	-2.0	-2.0	-1.1	1.6	2.3	-0.3	1.5	1.5	1.6
Happiness	1.7	2.0	4.9	1.4	-0.9	1.3	-1.1	0.8	1.6	-1.1	-1.4	-2.2	-1.4	-1.0	-2.1
Noisy workplace	0.8	0.9	3.4	-0.9	0.1	-0.1	-1.2	-1.8	-0.2	0.6	1.7	0.2	-0.9	0.4	1.1
Qualifications: A levels/AS levels or equivalent	1.3	2.8	7.2	2.7	-1.3	1.4	0.5	1.7	1.3	-2.1	-2.7	0.7	-0.8	-1.9	-1.6
Serious illness, injury or assault of a close relative in last 2 years	0.8	1.0	2.0	0.9	-0.9	0.7	1.4	0.6	1.1	-1.3	-1.3	0.1	-0.5	-1.3	-0.8
Mouth/teeth dental problems: Dentures	0.3	0.5	3.5	0.9	0.3	0.4	-1.9	0.4	0.5	0.0	0.2	-0.7	0.1	0.1	0.3
Asthma	2.6	5.1	7.9	2.6	-2.2	2.2	1.6	0.2	2.8	-2.6	-2.6	-1.8	-2.0	-2.6	-2.5
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	3.6	-0.3	1.3	-1.1	0.5	1.9	-0.9	0.2	-0.1	-0.8	0.4	0.4	0.4
Medication: Cholesterol lowering	1.4	2.2	3.7	-1.4	1.7	-1.6	0.2	0.4	-1.9	1.8	1.5	0.8	1.9	1.9	1.4
Depression (self-reported)	0.1	0.1	0.5	-0.0	0.1	-0.1	-0.7	0.1	-0.2	0.1	0.3	0.3	0.3	0.2	0.4
Medication: Lansoprazole	2.3	2.7	5.5	-2.3	1.4	-1.3	0.2	-1.2	-1.1	2.1	2.4	-1.2	1.0	2.0	1.9
Prospective memory result	2.6	3.2	5.8	-1.5	1.9	-1.8	-2.1	-0.2	-1.1	2.2	2.2	-1.6	1.0	2.1	2.4
Lung cancer (father)	0.5	0.6	3.6	0.9	-0.3	-0.0	0.2	-0.7	0.2	0.0	0.8	1.9	0.7	0.1	0.9
Illnesses of mother	0.7	0.8	1.8	0.9	-0.7	1.0	-0.5	0.6	1.3	-1.0	-0.9	-0.3	-1.2	-0.9	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	2.5	8.1	14.6	3.5	-2.5	2.8	-1.3	1.5	3.4	-3.8	-3.7	0.2	-2.6	-3.7	-2.6
Pulse wave Arterial Stiffness index	0.2	0.2	1.0	0.8	-0.2	-0.1	1.0	-0.0	0.3	-0.2	-0.4	-0.5	0.5	-0.1	-0.3
Impedance of arm (left)	3.6	16.8	29.5	-4.8	4.5	-4.7	-1.0	0.8	-5.4	5.1	3.9	0.5	4.2	5.1	4.5
Arm fat mass (right)	2.0	8.1	15.7	4.0	-3.4	3.3	-0.3	-1.2	3.4	-2.9	-2.9	-1.1	-2.4	-3.1	-3.6
Trunk predicted mass	23.9	136.7	309.8	17.6	-11.0	11.3	1.4	6.2	13.1	-14.1	-15.7	-0.9	-9.4	-13.9	-11.9
Standing height	21.3	211.6	522.5	22.9	-12.7	13.0	1.8	10.8	15.2	-17.4	-20.9	-0.8	-10.6	-17.1	-13.9
Length of working week for main job	1.8	2.0	4.4	1.7	-1.1	1.5	0.8	1.1	1.8	-1.4	-2.1	-1.2	-0.7	-1.3	-1.7
Exposure to tobacco smoke at home	0.8	0.9	6.1	0.3	-0.4	0.6	-0.0	-0.7	0.9	-0.3	-0.1	-2.5	-1.3	-0.4	-1.0
Breastfed as a baby	0.3	0.3	1.5	0.1	-0.1	0.3	0.3	1.2	0.5	-0.2	-0.6	-1.2	-0.6	-0.2	-0.1
Tense / ‘highly strung’	1.6	2.6	5.3	1.2	-1.7	1.9	-0.8	-0.4	2.0	-1.6	-1.1	-2.3	-1.8	-1.5	-1.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	3.7	1.4	-1.2	1.5	-0.4	0.0	1.4	-1.1	-1.2	-1.9	-1.0	-1.0	-1.8
Hair/balding pattern: Pattern 4	1.1	2.8	6.0	-1.4	1.9	-2.3	-0.1	0.7	-2.5	1.9	1.1	1.1	1.6	1.8	1.8
Birth weight of first child	0.8	1.4	3.5	-1.0	1.1	-1.5	-0.5	0.1	-1.6	1.2	1.2	0.9	1.3	1.2	1.9
Peak expiratory flow (PEF)	5.8	13.5	30.8	5.5	-3.1	3.2	0.1	2.6	3.7	-4.5	-5.3	-0.5	-3.0	-4.5	-3.6
Pulse wave reflection index	0.9	1.1	3.1	1.1	-0.8	0.8	1.8	-0.1	0.9	-1.1	-1.1	0.8	-1.0	-1.1	-1.1
Ever highly irritable/argumentative for 2 days	0.3	0.3	2.0	-0.2	-0.5	0.3	0.2	-0.7	0.6	0.0	-0.2	-1.4	0.5	0.0	-0.4
Loud music exposure frequency	0.9	0.9	5.8	-0.3	0.6	-0.4	-2.4	-0.5	-0.3	1.1	1.0	-0.7	0.6	1.0	0.5
Qualifications: O levels/GCSEs or equivalent	2.1	3.3	9.2	3.0	-2.0	1.8	1.3	0.4	2.1	-2.1	-2.0	0.6	-1.0	-2.0	-1.9
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.2	-1.0	0.8	-0.7	-0.2	-1.2	-1.3	1.0	1.5	-0.1	0.8	1.1	0.5
Blood clot in the leg (DVT)	0.6	0.8	2.2	1.3	-0.8	0.8	-0.5	0.2	1.5	-1.4	-0.9	0.2	-0.3	-1.1	-0.4
Medication: Paracetamol	0.1	0.2	0.5	-0.1	-0.3	0.4	0.5	-0.6	0.6	-0.7	-0.3	-0.0	-0.6	-0.6	-0.7
Headache pain in last month	1.3	2.2	3.9	1.1	-0.6	1.0	0.4	1.1	2.0	-2.0	-1.9	-1.4	-1.9	-1.9	-1.5
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.4	0.8	-0.4	0.6	-1.2	0.4	0.9	-0.9	-0.9	-0.7	-0.9	-0.9	-0.6
Glaucoma (self-reported)	0.5	0.6	4.3	-0.9	0.3	-0.2	-0.2	0.9	-0.8	0.2	0.1	2.1	-0.0	0.2	0.3
Gout (self-reported)	0.3	0.4	0.7	-0.8	0.7	-0.6	-0.3	-0.1	-0.4	0.6	0.6	-0.6	0.8	0.8	0.4
Hypothyroidism/myxoedema (self-reported)	3.0	5.9	10.6	2.5	-2.8	3.2	-0.3	-2.7	2.8	-2.1	-0.9	-2.0	-3.3	-2.4	-2.5
Medication: Amlodipine	0.1	0.2	1.0	0.6	-0.4	0.1	1.0	-0.1	0.2	-0.0	-0.3	0.1	0.4	-0.0	-0.4
Medication: Ventolin 100micrograms inhaler	2.8	3.6	9.9	2.1	-1.5	2.0	0.7	0.5	2.2	-2.0	-2.0	-1.0	-3.2	-2.2	-1.7
Birth weight	0.2	0.4	1.7	1.3	-0.7	0.6	0.4	0.5	0.5	-0.7	-0.9	0.0	0.1	-0.7	0.2
Chronic bronchitis/emphysema (mother)	0.8	0.9	3.6	-1.6	0.9	-0.6	-1.9	0.2	-0.6	0.9	0.8	0.2	0.5	0.9	0.8
High blood pressure (siblings)	4.2	6.1	9.2	2.1	-2.9	3.0	1.2	-1.4	2.8	-3.0	-1.9	-1.5	-2.6	-3.0	-2.9
Forced vital capacity (FVC), Best measure	2.6	9.4	17.9	4.2	-3.0	3.1	-0.7	1.6	3.3	-4.1	-4.0	1.0	-2.5	-3.9	-2.7
Body fat percentage	0.3	1.1	6.5	-1.1	-0.3	0.1	-0.0	-2.5	-0.4	1.1	1.3	-0.7	0.6	0.9	-0.2
Leg fat percentage (right)	1.4	4.9	13.2	-3.6	0.9	-1.0	0.0	-3.5	-1.8	2.6	3.4	-1.0	1.5	2.5	1.0
Arm fat-free mass (right)	21.6	110.7	234.1	15.3	-10.3	10.4	1.8	4.5	12.2	-12.8	-13.8	-0.6	-8.7	-12.7	-10.8
Exposure to tobacco smoke outside home	2.1	2.8	5.2	1.7	-1.7	2.0	-0.0	-0.8	1.8	-1.8	-1.5	-1.6	-2.3	-1.8	-1.9
Comparative body size at age 10	0.3	0.9	6.1	-1.0	-0.3	0.3	-1.4	-2.5	-0.3	0.5	0.9	-0.4	-0.3	0.3	-0.1
Number of full brothers	0.4	0.5	2.5	-0.8	0.6	-0.4	-1.6	-0.2	-0.4	0.9	0.5	0.6	0.0	0.6	0.7
Worry too long after embarrassment	0.1	0.1	0.2	-0.1	-0.1	0.0	-0.5	0.3	0.4	-0.4	-0.4	0.1	-0.3	-0.4	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.9	1.1	3.4	1.2	-0.5	0.9	-1.9	0.6	0.8	-0.8	-0.8	-1.6	-0.8	-0.6	-1.4
Wheeze or whistling in the chest in last year	3.5	6.2	11.4	3.1	-2.4	2.9	0.6	0.2	3.4	-2.9	-2.2	-1.5	-2.9	-2.8	-2.8
Number of children fathered	1.3	1.4	3.2	-0.6	0.7	-1.0	1.6	1.5	-1.5	0.8	-0.1	1.8	1.6	0.8	1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.7	0.8	3.0	0.7	-1.1	0.9	1.1	-1.7	0.6	-0.5	0.3	1.4	-0.8	-0.7	-0.1
Age at first live birth	0.4	0.6	2.9	0.4	-0.0	-0.2	0.8	1.7	-0.4	-0.5	-1.0	1.4	-0.4	-0.5	0.2
Pulse wave peak to peak time	0.4	0.5	1.0	0.6	-0.5	0.8	-0.8	0.6	0.4	-0.7	-0.8	0.7	-1.0	-0.8	-0.5
Health satisfaction	1.3	1.7	7.7	0.8	-1.1	1.2	-0.1	-1.2	1.8	-0.8	-0.6	-2.8	-0.8	-0.8	-1.5
Shortness of breath walking on level ground	2.9	3.4	9.8	1.5	-2.4	2.3	0.4	-3.1	2.4	-1.5	0.2	-1.1	-1.7	-1.6	-1.9
Qualifications: College or University degree	1.2	3.9	13.5	2.5	-1.0	0.9	1.7	3.7	1.0	-1.7	-3.4	1.4	-0.8	-1.6	-1.5
Eye problems/disorders: None of the above	0.2	0.3	1.4	0.2	0.3	-0.6	-0.1	0.4	-0.2	0.6	-0.3	-0.3	1.2	0.5	0.3
Mouth/teeth dental problems: Loose teeth	0.3	0.3	1.2	0.8	-0.7	0.7	0.2	-0.6	0.1	-0.5	-0.1	1.1	0.2	-0.5	-0.1
Emphysema/chronic bronchitis	0.2	0.2	1.1	-0.3	-0.2	0.1	-0.9	-1.1	0.2	0.0	0.7	-0.5	-0.3	0.0	-0.0
Medication for pain relief, constipation, heartburn	0.1	0.1	0.3	0.4	-0.5	0.1	0.3	-0.0	0.1	-0.2	-0.4	0.5	-0.1	-0.4	0.4
Neck or shoulder pain in last month	0.7	1.0	6.4	1.1	-0.1	0.7	-1.1	-0.4	0.5	-0.4	0.1	-2.5	-1.4	-0.4	-0.7
Medication: Blood pressure	0.7	1.2	3.8	1.0	-1.4	1.1	2.0	-0.9	0.8	-1.0	-0.7	0.1	-0.9	-1.1	-1.2
Angina (self-reported)	1.4	1.8	3.2	1.6	-1.6	1.7	0.3	-0.5	1.8	-1.3	-0.9	-1.4	-1.1	-1.3	-1.6
Migraine (self-reported)	5.5	6.9	12.3	2.0	-3.1	3.5	1.1	-0.6	2.9	-3.2	-2.3	-0.9	-3.1	-3.2	-3.1
Medication: Ibuprofen	0.3	0.4	2.3	0.3	0.6	-0.5	0.8	1.5	-0.3	-0.2	-0.4	-0.4	0.2	-0.1	-0.2
Medication: Allopurinol	0.3	0.4	1.1	-1.1	0.8	-0.7	-0.7	-0.5	-0.8	0.6	0.6	-0.2	0.4	0.7	0.4
Medication: Omeprazole	1.0	1.2	6.9	-0.5	0.2	-0.3	2.6	0.4	-0.7	0.0	0.2	2.6	-0.0	0.0	0.4
Medication: Seretide 50 evohaler	1.4	1.6	6.5	1.4	-1.3	1.0	2.5	0.5	1.3	-1.1	-1.3	-0.2	-0.8	-1.3	-1.1
Mean time to correctly identify matches	2.8	5.4	9.8	-2.1	2.2	-2.5	-0.3	-1.6	-3.1	2.8	3.0	1.5	2.1	2.7	2.6
Heart disease (mother)	0.4	0.5	2.4	-0.2	0.3	-0.1	-1.5	-0.6	-0.3	0.5	0.3	-1.5	0.6	0.6	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.2	2.5	-0.8	1.5	-1.2	-1.6	-0.2	-1.0	1.3	1.3	-0.6	0.6	1.4	1.0
Whole body fat mass	2.4	9.9	19.6	4.4	-3.7	3.6	0.3	-0.5	3.7	-3.4	-3.6	-0.9	-2.4	-3.5	-3.8
Leg fat mass (right)	1.0	4.1	7.6	2.3	-2.6	2.5	0.4	-1.5	2.4	-1.9	-1.7	-1.0	-1.6	-2.0	-2.8
Arm predicted mass (right)	22.1	113.2	238.8	15.5	-10.4	10.5	1.8	4.6	12.3	-12.9	-13.9	-0.7	-8.9	-12.8	-11.0
Pulse rate, automated reading	0.2	0.8	5.5	-0.5	-0.2	0.1	0.4	-2.3	-0.1	0.7	1.4	-0.6	0.2	0.5	0.4
Alcohol intake frequency.	1.0	2.4	4.9	1.1	-1.6	1.7	0.2	-0.9	1.6	-1.5	-1.0	-2.2	-2.0	-1.6	-1.9
Comparative height size at age 10	16.9	93.1	249.6	15.8	-9.2	9.2	0.8	5.1	9.9	-11.1	-13.5	-2.0	-6.8	-11.2	-9.6
Number of full sisters	0.9	1.1	6.2	-1.1	0.4	-0.5	-0.3	-2.5	-0.4	1.1	1.4	-1.3	-0.1	0.8	0.1
Suffer from ‘nerves’	1.3	2.0	3.8	1.3	-1.3	1.4	-0.4	0.4	1.7	-1.6	-1.6	-1.9	-1.1	-1.5	-1.9
Overall health rating	1.1	2.4	15.6	-0.2	-0.4	0.9	-1.6	-2.5	1.0	0.2	0.9	-4.0	-0.9	0.2	-0.8
Chest pain or discomfort	3.9	5.7	9.9	2.6	-2.5	2.9	0.8	0.4	2.8	-2.4	-2.6	-2.3	-1.9	-2.4	-3.1
Had major operations	0.2	0.3	0.7	-0.1	-0.5	0.6	0.8	-0.5	0.3	-0.4	0.3	-0.7	-0.8	-0.3	-0.4
Age at last live birth	1.0	1.5	4.0	1.7	-1.0	1.2	-0.3	1.0	0.9	-1.6	-2.0	-0.1	-0.8	-1.5	-1.1
Family relationship satisfaction	0.8	1.0	4.0	1.2	-0.6	1.1	-0.4	0.0	1.0	-0.9	-0.6	-0.3	-2.0	-1.0	-1.2
Leg pain on walking	0.3	0.4	1.0	-0.1	-0.5	0.8	-0.5	-0.6	1.0	-0.4	0.2	-0.9	-0.9	-0.4	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.2	-0.6	-0.1	-0.2	-0.8	-0.7	-0.7	1.1	0.9	0.6	1.1	1.0	0.5
Commuting to job workplace: Car/motor vehicle	0.8	0.9	2.5	-0.8	0.6	-0.5	0.0	-1.5	-0.7	1.1	1.6	0.4	0.8	1.2	0.7
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.3	-1.1	0.4	-1.0	1.1	-0.1	-1.3	1.1	0.5	1.5	1.1	0.9	1.0
Medication: Aspirin	1.1	1.5	2.9	-1.2	1.1	-1.3	-0.2	-0.3	-1.7	1.7	1.3	0.8	1.6	1.7	0.6
Supplements: Vitamin C	0.8	1.0	2.3	1.5	-1.2	1.3	-0.6	-0.2	0.8	-1.1	-0.6	-0.3	-1.2	-1.1	-1.0
Knee pain experienced in last month	12.7	19.8	40.8	-6.4	4.6	-4.2	-3.2	-1.9	-4.3	5.5	5.9	-1.8	3.0	5.5	4.3
Hypertension (Self-reported)	1.5	4.1	7.5	1.9	-2.7	2.6	1.1	-2.3	2.1	-2.1	-0.7	-1.1	-2.2	-2.1	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.3	-0.2	0.1	0.0	0.5	-0.0	0.3	0.1	0.1	-0.0	-0.0	0.0	-0.0
Illnesses of father: Heart disease	0.2	0.3	1.2	-0.6	0.4	-0.6	0.2	0.0	-1.1	0.9	0.4	-0.3	0.1	0.7	0.1
Illnesses of siblings: Diabetes	4.5	5.5	8.8	2.5	-3.0	2.7	1.3	-2.7	2.6	-2.2	-1.2	-1.9	-2.2	-2.2	-2.8
Smoking status: Previous	0.2	0.3	2.0	-1.4	0.2	-0.1	0.0	-0.2	-0.3	0.3	1.0	0.3	0.3	0.3	0.9
Forced expiratory volume in 1-second (FEV1), predicted	7.6	15.8	46.3	6.8	-3.2	3.3	-1.7	3.2	4.2	-4.7	-5.5	0.2	-2.6	-4.5	-3.6
Whole body fat-free mass	22.2	127.0	289.0	17.0	-10.8	11.0	1.2	5.5	12.7	-13.5	-15.0	-0.6	-9.2	-13.4	-11.5
Leg fat-free mass (right)	19.3	102.9	240.2	15.5	-9.9	10.0	0.7	4.4	11.4	-12.1	-13.3	-0.2	-8.5	-12.1	-10.3
Arm fat percentage (left)	0.4	1.4	9.6	-1.1	-0.5	0.4	-0.7	-3.1	-0.0	1.0	1.5	-1.1	0.0	0.7	-0.4
Average weekly red wine intake	0.9	1.4	7.5	0.5	0.9	-0.9	-0.8	2.7	-1.0	-0.2	-1.3	1.8	-0.1	-0.2	0.6
Handedness (chirality/laterality): Left-handed	0.2	0.3	2.1	0.0	-0.0	-0.5	1.4	0.7	-0.1	0.1	0.0	-0.7	0.2	0.0	0.5
Mood swings	2.3	4.2	10.3	1.5	-1.9	2.1	-1.3	-1.1	2.6	-1.8	-1.2	-3.2	-2.7	-1.9	-2.2
Loneliness, isolation	1.1	1.5	6.4	0.5	-0.3	0.7	-2.5	-1.8	0.9	-0.4	0.5	-1.8	-1.3	-0.5	-1.1
Long-standing illness, disability or infirmity	1.1	1.7	4.1	1.3	-1.0	1.5	-0.9	-0.9	1.5	-1.2	-0.4	-1.8	-2.0	-1.1	-1.1
Ever had bowel cancer screening	1.8	2.1	6.3	1.3	-0.9	1.4	-2.5	-0.2	1.4	-1.1	-0.8	-1.4	-2.1	-1.2	-1.5
Diabetes diagnosed by doctor	1.7	2.9	5.2	1.9	-1.6	1.9	0.9	0.3	2.1	-1.8	-2.2	-1.1	-1.4	-1.8	-2.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	1.1	0.0	-0.4	0.5	-1.0	-0.9	0.2	-0.2	0.2	-1.0	-1.1	-0.3	-0.7
Friendships satisfaction	0.9	1.1	4.2	0.6	-0.9	1.3	-0.6	-2.1	0.8	-0.7	0.4	0.3	-1.7	-0.8	-1.0
Qualifications: nursing, teaching	0.4	0.6	1.7	0.9	-1.1	0.9	1.0	0.1	0.4	-0.6	-0.4	1.3	-0.8	-0.7	-0.5
Commuting to job workplace: Walk	3.4	3.7	7.7	2.1	-1.5	1.4	1.7	1.8	1.9	-2.4	-2.8	-1.3	-1.8	-2.4	-1.4
Eye problems/disorders: Cataract	1.2	1.4	4.1	1.2	-1.0	1.4	0.1	0.5	1.4	-1.4	-0.9	-0.2	-2.0	-1.4	-1.2
Mouth/teeth dental problems: Mouth ulcers	1.0	1.5	4.3	-2.1	1.5	-1.6	-0.0	0.6	-1.7	1.2	0.8	0.6	0.9	1.3	0.9
Medication for cholesterol	0.2	0.4	1.1	-0.1	0.5	-0.5	-0.2	-0.2	-1.0	0.6	0.6	1.0	0.3	0.5	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.8	0.4	-0.3	0.5	-0.8	0.1	0.2	-0.2	-0.5	-0.9	0.3	-0.1	-0.7
Back pain experienced in last month	2.2	3.2	9.6	-1.3	2.0	-1.3	-3.1	-0.1	-1.5	1.9	2.0	0.2	2.0	2.1	1.8
Mineral and other dietary supplements	0.3	0.4	1.1	0.7	-0.0	0.5	-0.2	-0.0	1.0	-0.5	-1.0	-0.6	-0.0	-0.4	-1.1
Breast cancer (self-reported)	0.4	0.5	2.0	0.3	-0.6	0.5	-0.7	-0.4	1.1	-0.5	-0.1	-1.4	-0.9	-0.6	-0.4
Asthma (self-reported)	2.5	4.9	7.8	2.6	-2.1	2.2	1.2	-0.0	2.8	-2.6	-2.5	-1.7	-2.1	-2.6	-2.5
Osteoporosis (self-reported)	0.5	0.6	4.3	-1.0	-0.0	-0.1	-0.5	-2.1	-0.2	0.4	1.1	-0.2	0.1	0.3	0.6
Osteoarthritis (self-reported)	0.5	0.7	2.3	-1.5	-0.1	0.1	-1.2	-1.2	-0.6	0.8	1.2	-0.1	0.1	0.7	0.3
Medication: Aspirin	0.6	0.8	1.7	-0.6	0.5	-0.8	-0.1	-0.5	-1.1	1.0	0.9	1.3	1.3	1.0	0.3
Medication: Gliclazide	0.7	0.8	1.8	1.3	-0.9	0.9	-0.8	-0.3	0.7	-0.9	-1.0	0.1	-0.6	-1.0	-1.2
Illnesses of father: None of the above (group 1)	0.2	0.2	1.3	0.0	-0.2	0.3	1.2	0.4	0.2	-0.5	-0.4	0.8	0.2	-0.4	0.2
Smoking status: Current	0.5	0.7	2.9	0.3	-0.5	0.8	-1.7	-1.6	0.7	-0.5	0.2	-1.0	-0.5	-0.5	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	2.0	7.1	-2.7	1.5	-1.4	-1.5	0.3	-1.1	1.4	1.4	-1.0	0.4	1.4	1.3
Whole body water mass	22.2	126.4	285.6	16.9	-10.8	11.0	1.3	5.4	12.7	-13.5	-14.9	-0.7	-9.2	-13.4	-11.5
Leg predicted mass (right)	19.2	102.5	240.2	15.5	-9.8	10.0	0.8	4.4	11.4	-12.0	-13.3	-0.2	-8.4	-12.1	-10.3
Arm fat mass (left)	2.3	9.6	17.0	4.1	-3.6	3.6	-0.1	-1.1	3.8	-3.2	-3.2	-1.0	-2.7	-3.5	-3.8
Number of self-reported non-cancer illnesses	2.5	4.3	10.7	1.9	-2.5	2.7	-0.5	-3.3	2.3	-1.7	-0.0	-1.0	-2.4	-1.8	-2.1
Average weekly champagne plus white wine intake	1.6	2.2	4.9	1.7	-1.4	1.2	2.2	0.4	1.2	-2.1	-1.8	0.8	-0.6	-1.9	-1.3
Miserableness	0.3	0.5	2.7	-0.1	-0.0	0.3	-1.4	-1.0	0.4	0.1	0.3	-1.7	-0.3	0.1	-0.6
Guilty feelings	2.4	3.7	8.2	1.7	-2.4	2.3	-0.1	-1.0	2.9	-2.4	-1.2	-0.9	-2.0	-2.3	-2.0
Wears glasses or contact lenses	0.4	0.5	2.7	-0.6	0.4	-0.8	1.1	1.6	0.1	0.2	-0.5	0.2	0.2	0.1	0.4
Ever taken oral contraceptive pill	2.7	3.0	5.3	-2.2	1.5	-2.0	0.8	-0.3	-2.3	1.8	1.6	1.5	1.9	1.8	2.1
Hearing aid user	1.6	1.8	4.4	-1.2	1.4	-1.9	0.8	1.1	-1.4	1.0	0.7	2.1	0.8	0.8	2.0
Mother’s age at death	0.7	0.9	2.2	-0.7	1.1	-1.1	0.4	1.0	-1.5	0.9	0.3	0.7	0.8	0.8	1.2
Financial situation satisfaction	1.8	2.2	5.2	0.8	-0.7	1.2	-2.3	-1.1	2.2	-1.2	-0.4	-2.1	-2.1	-1.2	-1.1
Tinnitus: Yes, now most or all of the time	0.9	1.1	3.0	1.2	-0.9	0.8	0.8	1.3	0.9	-1.0	-1.7	-0.6	-0.6	-1.0	-1.3
Commuting to job workplace: Public transport	0.9	1.1	3.1	1.0	-0.4	0.7	1.0	1.8	1.0	-0.9	-1.6	-0.9	-0.8	-0.9	-0.6
Eye problems/disorders: Glaucoma	2.1	2.4	4.6	-2.1	1.6	-1.5	-0.4	1.1	-2.1	1.7	1.3	1.8	1.0	1.6	1.5
Medication: Blood pressure	2.2	4.2	7.5	2.2	-2.3	2.3	1.3	0.1	2.7	-2.4	-2.2	-1.8	-1.3	-2.3	-2.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.4	0.1	0.3	-0.1	-0.6	-1.2	-0.7	0.4	0.6	-0.9	0.8	0.5	0.0
Supplements: Fish oil (including cod liver oil)	0.1	0.2	1.2	-0.2	-0.4	0.2	1.1	-0.0	-0.4	-0.1	0.5	0.3	-0.6	-0.1	0.2
High cholesterol (Self-reported)	2.1	3.7	6.5	-2.0	2.1	-2.2	0.4	0.9	-2.6	2.3	1.6	0.0	2.5	2.4	1.8
Medication: Bendroflumethiazide	2.0	3.0	6.2	1.5	-2.2	1.6	2.5	-0.3	2.2	-1.8	-1.5	-1.1	-1.3	-1.9	-1.7
Medication: Paracetamol	0.1	0.2	0.5	0.3	-0.2	0.2	0.5	-0.2	0.3	-0.5	-0.3	-0.1	-0.4	-0.5	-0.7
Medication: Lisinopril	0.7	1.0	2.0	0.9	-1.2	1.3	0.2	-0.9	1.4	-0.9	-0.7	-0.9	-0.8	-0.9	-1.2
Medication: Atorvastatin	0.7	0.8	2.4	-0.7	0.6	-0.5	-0.3	-0.7	-0.3	1.1	1.3	-1.5	1.1	1.2	0.7
Illnesses of father: High blood pressure	0.8	1.0	1.8	0.9	-1.4	1.3	0.6	-0.4	1.1	-1.3	-0.7	-0.4	-1.1	-1.2	-1.1
Alcohol drinker status: Never	0.8	1.0	2.6	-1.1	1.0	-0.8	-0.2	-0.3	-1.3	1.4	1.6	0.2	0.5	1.3	0.9
Ever smoked	0.3	0.6	1.2	0.2	-1.0	1.0	-0.8	-0.9	1.1	-0.9	-0.1	-0.3	-0.9	-1.0	-0.3
Basal metabolic rate	19.7	108.8	249.6	15.8	-10.1	10.3	1.0	4.7	11.8	-12.4	-13.8	-0.7	-8.6	-12.4	-10.7
Leg fat percentage (left)	1.0	3.6	14.3	-3.0	0.2	-0.4	0.2	-3.8	-1.1	2.0	2.9	-1.2	1.1	1.8	0.5
Arm fat-free mass (left)	20.1	101.8	223.8	15.0	-9.8	9.9	1.2	4.6	11.6	-12.1	-13.3	-1.0	-8.2	-12.1	-10.4
Number of operations (self-reported)	0.7	1.0	3.8	-0.4	-0.9	1.0	1.6	-2.0	0.3	-0.1	1.1	-1.2	-0.9	-0.2	-0.3
Average weekly beer plus cider intake	1.2	1.8	5.4	-1.7	0.6	-0.6	-0.4	-2.3	-0.8	1.5	2.1	-0.5	1.2	1.5	1.0
Irritability	0.6	1.0	2.1	0.1	-0.7	0.5	0.9	1.1	1.1	-1.3	-1.3	-0.7	-1.5	-1.3	-1.0
Risk taking	1.0	1.4	5.7	1.2	-1.0	1.3	-2.4	-0.2	1.1	-0.9	-0.6	-0.8	-1.4	-0.8	-1.2
Ever had prostate specific antigen (PSA) test	0.6	0.6	2.8	0.6	-0.2	0.1	1.1	1.7	0.1	-0.8	-1.3	-0.1	-0.3	-0.7	-0.6
Fractured/broken bones in last 5 years	0.7	0.9	3.0	-0.7	0.9	-1.1	-0.3	0.9	-1.2	0.9	0.2	-0.1	1.7	1.1	0.7
Age started oral contraceptive pill	0.6	0.7	4.8	0.0	0.6	-0.4	-1.4	2.2	0.6	-0.3	-0.6	-0.9	-0.1	-0.1	0.4
Diastolic blood pressure, automated reading	0.6	1.8	3.8	1.1	-1.6	1.4	0.1	-1.9	1.2	-1.0	-0.6	-1.8	-1.3	-1.2	-1.7
Ever depressed for a whole week	1.2	1.4	5.6	-1.0	0.4	-0.5	-0.5	-1.2	-1.2	1.2	1.7	2.4	0.5	0.9	1.3
Unable to work because of sickness or disability	1.3	1.7	8.5	-0.6	0.1	0.3	-2.6	-2.9	0.1	0.5	1.6	-1.3	-0.1	0.5	0.5
Commuting to job workplace: Cycle	1.1	1.3	3.2	1.4	-0.4	0.5	-1.2	1.4	0.7	-1.0	-1.8	1.4	-1.0	-1.2	-0.8
Myopia	4.3	6.2	15.4	2.7	-2.0	1.8	2.0	2.6	2.7	-2.6	-3.9	-0.6	-2.1	-2.7	-2.7
Vascular/heart problems diagnosed by doctor	1.8	4.8	8.6	-1.8	2.9	-2.8	-1.3	2.5	-2.4	2.1	0.8	1.6	2.2	2.2	2.6
Cholesterol lowering medication	0.8	1.2	3.9	-1.2	1.1	-1.3	0.5	1.4	-0.9	1.0	0.4	-0.1	2.0	1.2	0.9
Medication: Omeprazole (e.g. Zanprol)	0.9	1.1	5.6	-0.5	0.2	-0.5	2.3	0.3	-0.9	0.3	0.3	2.4	0.6	0.3	0.5
Pain experienced in last month	0.9	1.5	3.8	1.3	-1.1	0.5	1.1	1.1	1.1	-1.4	-2.0	1.5	-0.6	-1.5	-0.8
Supplements: Calcium	0.4	0.4	2.3	0.4	-0.2	0.2	-1.5	-0.8	0.3	0.0	0.4	-1.1	-0.5	-0.0	0.1
Basal cell carcinoma (self-reported)	0.5	0.7	1.8	-0.2	0.3	-0.7	1.4	0.3	-1.3	0.9	0.6	-0.5	1.0	1.0	0.3
Heart attack/myocardial infarction (self-reported)	0.5	0.6	3.1	0.5	-1.1	0.8	1.8	-1.1	0.8	-0.4	0.1	-0.1	-0.2	-0.5	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.6	0.8	2.2	1.3	-0.8	0.7	-0.2	0.3	1.5	-1.4	-0.9	0.4	-0.3	-1.1	-0.3
Heart disease (siblings)	0.5	0.6	3.7	0.2	-1.0	0.9	-1.1	-1.9	0.5	-0.2	0.3	0.0	-0.4	-0.3	-0.5
Alcohol drinker status: Previous	0.9	1.0	2.2	1.5	-1.1	1.0	1.2	-0.1	1.2	-1.3	-1.0	-0.1	-0.4	-1.2	-0.5
Pack years of smoking	1.1	1.6	3.3	1.8	-1.6	1.7	-0.3	-0.9	1.5	-1.2	-1.0	-0.6	-0.6	-1.2	-1.6
Impedance of whole body	4.9	25.0	42.5	-6.5	5.3	-5.6	-0.4	0.1	-6.4	6.1	5.3	0.4	5.1	6.1	5.4
Leg fat mass (left)	1.6	6.1	10.5	2.9	-3.2	3.1	0.6	-1.6	3.0	-2.5	-2.3	-1.1	-2.0	-2.7	-3.2
Arm predicted mass (left)	20.0	101.9	228.0	15.1	-9.8	9.9	1.1	4.5	11.6	-12.1	-13.3	-1.0	-8.1	-12.0	-10.5