[Hub]/) : Traits : Impedance of arm (left) : ← →

chr2:197,134,790-200,117,777

Best TWAS P=1.91e-33 · Best GWAS P=2.33e-33 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
19	GTEx	Spleen	RFTN2	0.11	0.03	enet	26	0.05	2.4e-02	11.93	12.1	1.9e-33	0.98	0.04	0.68	TRUE
18	GTEx	Skin Sun Exposed Lower leg	MARS2	0.04	0.05	enet	8	0.03	1.2e-03	12.01	-12.0	2.1e-33	-0.99	0.03	0.97	FALSE
13	GTEx	Lung	RFTN2	0.06	0.08	lasso	8	0.06	2.7e-05	11.98	12.0	2.7e-33	0.98	0.03	0.97	FALSE
20	GTEx	Spleen	MARS2	0.12	0.04	lasso	5	0.00	3.4e-01	12.00	-11.9	8.8e-33	-0.98	0.04	0.61	FALSE
25	GTEx	Thyroid	PLCL1	0.04	0.01	lasso	4	0.00	2.6e-01	11.65	11.7	9.5e-32	0.91	0.12	0.69	FALSE
38	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	RFTN2	0.05	0.01	blup	61	0.02	3.1e-02	9.42	11.6	5.0e-31	0.82	0.04	0.39	FALSE
24	GTEx	Thyroid	SF3B1	0.04	0.02	enet	14	0.02	2.0e-02	9.19	11.3	2.1e-29	0.81	0.10	0.81	FALSE
6	GTEx	Breast Mammary Tissue (Female)	SF3B1	0.05	-0.01	lasso	3	-0.01	8.1e-01	9.47	11.2	5.6e-29	0.77	0.05	0.10	FALSE
5	GTEx	Breast Mammary Tissue	SF3B1	0.06	0.06	lasso	4	0.03	6.6e-03	9.41	10.8	3.6e-27	0.72	0.18	0.66	FALSE
27	GTEx	Whole Blood	PLCL1	0.08	0.08	enet	15	0.05	4.1e-05	11.15	10.6	2.1e-26	0.86	0.53	0.47	FALSE
23	GTEx	Testis	SF3B1	0.10	0.07	enet	17	0.08	2.6e-04	9.44	9.8	1.6e-22	0.65	0.48	0.46	FALSE
35	YFS	Blood	PLCL1	0.10	0.10	lasso	9	0.14	1.5e-43	11.26	9.8	1.7e-22	0.79	0.97	0.03	FALSE
3	GTEx	Adipose Subcutaneous	RFTN2	0.14	0.10	enet	11	0.13	5.3e-11	11.15	9.7	2.6e-22	0.85	0.13	0.87	FALSE
14	GTEx	Nerve Tibial	SF3B1	0.06	0.09	lasso	8	0.08	3.3e-06	9.47	9.6	5.7e-22	0.60	0.97	0.03	FALSE
26	GTEx	Thyroid	RFTN2	0.04	0.01	enet	11	0.01	9.5e-02	11.99	9.6	1.0e-21	0.89	0.03	0.90	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SF3B1	0.06	0.07	enet	10	0.07	2.5e-09	9.44	9.5	2.8e-21	0.57	1.00	0.00	FALSE
10	GTEx	Esophagus Mucosa	SF3B1	0.04	0.02	lasso	4	0.01	5.7e-02	9.45	9.2	2.6e-20	0.56	0.32	0.05	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	MARS2	0.15	0.14	lasso	4	0.07	2.6e-03	-8.56	-9.1	1.4e-19	-0.76	0.05	0.72	FALSE
33	ROSMAP	Brain Pre-frontal Cortex	MARS2	0.05	0.03	enet	14	0.05	2.2e-07	-8.11	-9.0	2.2e-19	-0.87	0.04	0.96	FALSE
36	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	PLCL1	0.04	0.00	blup	130	0.02	4.0e-03	-2.97	8.8	1.1e-18	0.66	0.04	0.45	FALSE
11	GTEx	Esophagus Muscularis	SF3B1	0.06	0.02	lasso	4	0.03	1.0e-02	9.58	8.8	2.0e-18	0.49	0.17	0.19	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	SF3B1	0.02	0.01	blup	336	0.01	6.2e-03	8.99	8.6	1.2e-17	0.54	0.57	0.07	FALSE
30	NTR	Blood	PLCL1	0.02	0.01	enet	14	0.02	1.9e-06	11.13	8.4	3.2e-17	0.68	0.34	0.57	FALSE
9	GTEx	Colon Transverse	MARS2	0.17	0.12	lasso	4	0.13	7.4e-07	-8.56	-7.8	4.3e-15	-0.69	0.23	0.44	FALSE
29	NTR	Blood	ANKRD44	0.03	0.00	bslmm	417	0.02	2.7e-06	8.84	-7.7	1.2e-14	-0.54	0.18	0.69	FALSE
12	GTEx	Lung	SF3B1	0.06	0.04	enet	23	0.02	2.2e-02	9.45	7.4	1.0e-13	0.53	0.41	0.31	FALSE
37	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	MOBKL3	0.03	0.01	blup	32	0.02	6.3e-03	10.96	7.3	2.4e-13	0.75	0.01	0.56	FALSE
16	GTEx	Skin Not Sun Exposed Suprapubic	SF3B1	0.08	0.00	enet	19	0.01	1.6e-01	9.42	7.2	4.9e-13	0.40	0.31	0.05	FALSE
28	METSIM	Adipose	PLCL1	0.06	0.01	blup	517	0.05	3.6e-08	-3.90	7.2	7.2e-13	0.77	0.13	0.86	FALSE
22	GTEx	Testis	ANKRD44	0.33	0.35	enet	15	0.36	6.2e-17	7.26	7.0	2.0e-12	0.46	1.00	0.00	FALSE
7	GTEx	Cells EBV-transformed lymphocytes	HSPD1	0.15	0.04	lasso	7	0.04	2.0e-02	4.30	-7.0	3.4e-12	-0.72	0.12	0.55	FALSE
15	GTEx	Pituitary	HSPD1	0.10	0.03	enet	12	0.06	1.3e-02	1.41	6.8	7.5e-12	0.49	0.08	0.32	FALSE
4	GTEx	Adrenal Gland	ANKRD44	0.15	0.05	lasso	5	0.15	3.9e-06	-1.42	-6.7	2.0e-11	-0.48	0.21	0.45	FALSE
34	YFS	Blood	ANKRD44	0.02	0.00	blup	416	0.01	6.3e-04	-1.46	-6.6	4.9e-11	-0.44	0.14	0.49	FALSE
1	CommonMind	Brain Pre-frontal Cortex	PLCL1	0.06	0.01	blup	397	0.02	4.9e-04	0.88	6.5	9.4e-11	0.54	0.03	0.76	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	PLCL1	0.07	0.06	blup	130	0.07	1.8e-07	8.79	-5.9	3.3e-09	-0.19	0.99	0.00	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	RFTN2	0.03	0.04	blup	351	0.03	1.5e-04	8.71	-5.8	7.0e-09	-0.25	0.92	0.01	FALSE
21	GTEx	Stomach	SF3B1	0.11	0.00	enet	19	0.00	4.0e-01	9.61	5.4	8.2e-08	0.33	0.09	0.16	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	MARS2	0.22	0.02	enet	30	0.02	3.6e-02	11.78	-5.3	9.5e-08	-0.53	0.06	0.51	FALSE