Best TWAS P=1.94e-18 · Best GWAS P=3.04e-18 conditioned to 0.00252
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PPP2R3A | 0.05 | 0.02 | lasso | 4 | 0.05 | 7.7e-07 | -8.6 | -7.3 | 2.9e-13 | 0.74 | 0.03 | 0.96 | FALSE |
| 2 | GTEx | Adipose Visceral Omentum | PPP2R3A | 0.08 | 0.00 | enet | 17 | 0.00 | 3.0e-01 | -7.4 | -5.3 | 1.2e-07 | 0.68 | 0.10 | 0.57 | FALSE |
| 3 | GTEx | Artery Coronary | SLC35G2 | 0.16 | 0.03 | lasso | 8 | 0.05 | 6.4e-03 | -8.0 | 8.8 | 1.9e-18 | -0.78 | 0.09 | 0.61 | TRUE |
| 4 | GTEx | Artery Tibial | PPP2R3A | 0.07 | 0.07 | lasso | 2 | 0.05 | 1.5e-04 | -4.8 | -5.2 | 1.9e-07 | 0.73 | 0.51 | 0.17 | FALSE |
| 5 | GTEx | Brain Cerebellar Hemisphere | RP11-731C17.2 | 0.16 | 0.02 | enet | 24 | 0.09 | 3.0e-03 | 7.5 | -6.8 | 1.5e-11 | 0.25 | 0.22 | 0.05 | FALSE |
| 6 | GTEx | Brain Cerebellum | PPP2R3A | 0.28 | -0.01 | enet | 21 | 0.04 | 2.9e-02 | -8.1 | -5.6 | 1.7e-08 | 0.55 | 0.06 | 0.51 | FALSE |
| 7 | GTEx | Brain Cerebellum | RP11-731C17.2 | 0.31 | 0.05 | enet | 39 | 0.12 | 2.3e-04 | 4.2 | -6.8 | 8.7e-12 | 0.42 | 0.34 | 0.13 | FALSE |
| 8 | GTEx | Breast Mammary Tissue (Male) | RP11-85F14.5 | 0.08 | 0.12 | lasso | 1 | 0.06 | 1.6e-02 | -6.8 | -6.8 | 1.2e-11 | 0.62 | 0.06 | 0.27 | FALSE |
| 9 | GTEx | Cells Transformed fibroblasts | RP11-85F14.5 | 0.10 | 0.08 | enet | 38 | 0.09 | 3.9e-07 | 4.1 | -6.7 | 2.4e-11 | 0.48 | 0.94 | 0.04 | FALSE |
| 10 | GTEx | Esophagus Mucosa | PPP2R3A | 0.06 | 0.06 | lasso | 3 | 0.04 | 9.1e-04 | -5.1 | -5.1 | 3.0e-07 | 0.71 | 0.41 | 0.43 | FALSE |
| 11 | GTEx | Esophagus Mucosa | RP11-85F14.5 | 0.13 | 0.10 | lasso | 3 | 0.11 | 5.1e-08 | 5.8 | -5.8 | 5.5e-09 | 0.27 | 1.00 | 0.00 | FALSE |
| 12 | GTEx | Esophagus Muscularis | RP11-731C17.2 | 0.16 | 0.03 | enet | 13 | 0.06 | 1.1e-04 | -3.0 | -6.0 | 1.6e-09 | 0.66 | 0.19 | 0.72 | FALSE |
| 13 | GTEx | Lung | RP11-85F14.5 | 0.07 | 0.05 | lasso | 19 | 0.05 | 8.8e-05 | 5.8 | -5.9 | 3.8e-09 | 0.28 | 0.95 | 0.01 | FALSE |
| 14 | GTEx | Muscle Skeletal | RP11-85F14.5 | 0.10 | 0.08 | lasso | 17 | 0.09 | 6.3e-09 | 4.2 | -6.7 | 1.7e-11 | 0.54 | 0.82 | 0.18 | FALSE |
| 15 | GTEx | Muscle Skeletal | RP11-731C17.2 | 0.15 | 0.12 | lasso | 16 | 0.12 | 3.8e-12 | 4.2 | -6.3 | 2.5e-10 | 0.46 | 1.00 | 0.00 | FALSE |
| 16 | GTEx | Skin Sun Exposed Lower leg | RP11-85F14.5 | 0.04 | 0.01 | enet | 9 | 0.03 | 2.8e-03 | 4.0 | -5.5 | 4.8e-08 | 0.35 | 0.38 | 0.16 | FALSE |
| 17 | GTEx | Stomach | PPP2R3A | 0.08 | 0.02 | lasso | 4 | 0.05 | 1.9e-03 | -7.4 | 6.0 | 2.0e-09 | -0.80 | 0.12 | 0.78 | FALSE |
| 18 | GTEx | Testis | RP11-85F14.5 | 0.12 | 0.03 | enet | 28 | 0.02 | 3.8e-02 | 3.9 | -6.6 | 4.4e-11 | 0.51 | 0.38 | 0.35 | FALSE |
| 19 | GTEx | Thyroid | PPP2R3A | 0.10 | 0.05 | enet | 18 | 0.06 | 1.3e-05 | -5.1 | -6.5 | 7.1e-11 | 0.76 | 0.06 | 0.93 | FALSE |
| 20 | GTEx | Thyroid | RP11-85F14.5 | 0.07 | 0.00 | lasso | 7 | 0.01 | 4.7e-02 | 5.8 | -8.6 | 7.5e-18 | 0.54 | 0.13 | 0.11 | FALSE |
| 21 | YFS | Blood | MSL2 | 0.02 | 0.04 | lasso | 2 | 0.03 | 9.9e-11 | -8.1 | 8.0 | 1.0e-15 | -0.96 | 0.03 | 0.97 | FALSE |
| 22 | YFS | Blood | NCK1 | 0.01 | 0.02 | enet | 4 | 0.02 | 2.2e-06 | 5.8 | -5.8 | 5.5e-09 | 0.27 | 0.98 | 0.00 | FALSE |
| 23 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | STAG1 | 0.04 | 0.02 | lasso | 3 | 0.02 | 4.1e-03 | -7.4 | 6.5 | 6.9e-11 | -0.73 | 0.14 | 0.63 | FALSE |
| 24 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PCCB | 0.06 | 0.02 | lasso | 2 | 0.03 | 2.3e-04 | -8.4 | 6.0 | 2.6e-09 | -0.74 | 0.03 | 0.94 | FALSE |