Best TWAS P=1.32e-15 · Best GWAS P=5.48e-17 conditioned to 0.00648
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | POC5 | 0.17 | 0.16 | lasso | 5 | 0.15 | 5.2e-18 | 7.8 | -8.0 | 1.3e-15 | -0.90 | 0.06 | 0.94 | TRUE |
| 2 | GTEx | Adrenal Gland | GCNT4 | 0.13 | 0.02 | lasso | 8 | 0.01 | 1.3e-01 | 4.5 | 5.8 | 8.1e-09 | 0.49 | 0.06 | 0.84 | FALSE |
| 3 | GTEx | Brain Cerebellar Hemisphere | POLK | 0.27 | 0.20 | lasso | 6 | 0.16 | 8.3e-05 | 4.6 | 5.8 | 8.8e-09 | 0.64 | 0.34 | 0.16 | FALSE |
| 4 | GTEx | Brain Cerebellar Hemisphere | POC5 | 0.31 | 0.15 | enet | 18 | 0.30 | 1.6e-08 | 5.0 | 6.2 | 5.7e-10 | 0.61 | 0.58 | 0.27 | FALSE |
| 5 | GTEx | Spleen | POLK | 0.18 | -0.01 | lasso | 16 | 0.03 | 5.1e-02 | 4.3 | 6.8 | 8.0e-12 | 0.59 | 0.16 | 0.22 | FALSE |
| 6 | GTEx | Spleen | POC5 | 0.42 | 0.37 | lasso | 4 | 0.34 | 1.3e-09 | 5.0 | 5.1 | 3.1e-07 | 0.57 | 0.94 | 0.04 | FALSE |
| 7 | GTEx | Spleen | CTC-366B18.2 | 0.16 | 0.11 | lasso | 3 | 0.14 | 2.2e-04 | 5.0 | 6.4 | 1.6e-10 | 0.72 | 0.15 | 0.44 | FALSE |
| 8 | GTEx | Testis | POC5 | 0.27 | 0.13 | lasso | 8 | 0.09 | 8.1e-05 | 6.3 | -5.7 | 1.6e-08 | -0.65 | 0.55 | 0.26 | FALSE |
| 9 | GTEx | Testis | GCNT4 | 0.42 | 0.35 | enet | 62 | 0.37 | 3.8e-17 | 5.1 | 5.5 | 2.8e-08 | 0.50 | 1.00 | 0.00 | FALSE |
| 10 | GTEx | Thyroid | CTC-366B18.2 | 0.06 | 0.03 | lasso | 9 | 0.02 | 6.2e-03 | 5.5 | 5.7 | 1.5e-08 | 0.62 | 0.30 | 0.17 | FALSE |
| 11 | METSIM | Adipose | POLK | 0.05 | 0.01 | enet | 16 | 0.03 | 4.3e-05 | 6.9 | 6.8 | 1.0e-11 | 0.58 | 0.95 | 0.03 | FALSE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | POLK | 0.03 | 0.01 | lasso | 7 | 0.02 | 3.9e-03 | 5.9 | 7.1 | 1.1e-12 | 0.81 | 0.27 | 0.63 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | POC5 | 0.05 | 0.00 | blup | 384 | 0.02 | 8.6e-04 | 4.7 | 5.9 | 4.1e-09 | 0.57 | 0.30 | 0.13 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | ANKDD1B | 0.07 | 0.00 | bslmm | 382 | 0.03 | 7.0e-05 | 2.1 | -5.5 | 3.8e-08 | -0.63 | 0.08 | 0.55 | FALSE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | POC5 | 0.04 | 0.00 | enet | 7 | 0.03 | 2.1e-04 | 7.8 | -6.8 | 7.9e-12 | -0.77 | 0.02 | 0.58 | FALSE |
| 16 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | HMGCR | 0.04 | 0.02 | enet | 4 | 0.03 | 6.0e-03 | 5.7 | 5.8 | 8.2e-09 | 0.57 | 0.02 | 0.74 | FALSE |
| 17 | The Cancer Genome Atlas | Uterine Corpus Endometrial Carcinoma | POC5 | 0.24 | 0.13 | blup | 70 | 0.14 | 1.2e-04 | 5.6 | 6.0 | 2.5e-09 | 0.73 | 0.05 | 0.80 | FALSE |