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chr20:24,230,055-26,307,797

Best TWAS P=1.46e-13 · Best GWAS P=1.24e-11 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	CommonMind	Brain Pre-frontal Cortex	NINL	0.19	0.17	lasso	20	0.23	1.2e-27	6.4	7.4	1.5e-13	0.83	0.09	0.91	TRUE
44	ROSMAP	Brain Pre-frontal Cortex	ENTPD6	0.32	0.10	bslmm	432	0.12	1.8e-15	6.0	7.2	5.9e-13	0.23	0.58	0.42	TRUE
45	YFS	Blood	ABHD12	0.15	0.35	bslmm	390	0.34	2.2e-118	6.5	6.8	9.8e-12	0.83	0.06	0.94	TRUE
41	ROSMAP	Brain Pre-frontal Cortex	PYGB	0.20	0.10	bslmm	414	0.11	3.2e-14	5.5	-6.4	1.5e-10	-0.66	0.55	0.45	TRUE
16	GTEx	Cells EBV-transformed lymphocytes	PYGB	0.38	0.08	lasso	5	0.06	7.0e-03	5.7	5.7	1.0e-08	0.65	0.11	0.76	TRUE
28	GTEx	Lung	NINL	0.07	0.05	lasso	4	0.04	5.3e-04	-4.3	-5.5	3.7e-08	-0.72	0.10	0.88	TRUE
62	The Cancer Genome Atlas	Prostate Adenocarcinoma	PYGB	0.21	0.13	enet	5	0.17	2.0e-17	4.1	-5.4	7.6e-08	-0.38	1.00	0.00	TRUE
11	GTEx	Brain Cerebellum	ENTPD6	0.15	0.23	enet	8	0.14	4.6e-05	5.1	-5.3	9.9e-08	-0.71	0.20	0.76	TRUE
1	CommonMind	Brain Pre-frontal Cortex	ABHD12	0.10	0.17	blup	405	0.17	1.7e-20	6.4	7.2	4.3e-13	0.77	0.08	0.92	FALSE
33	GTEx	Pituitary	ABHD12	0.27	0.31	enet	25	0.31	1.8e-08	6.4	7.0	2.2e-12	0.77	0.09	0.91	FALSE
6	GTEx	Artery Aorta	NINL	0.17	0.18	lasso	6	0.19	1.5e-10	6.4	6.8	1.4e-11	0.80	0.08	0.92	FALSE
23	GTEx	Heart Left Ventricle	ABHD12	0.15	0.14	lasso	10	0.12	4.0e-07	6.5	6.7	2.3e-11	0.82	0.07	0.93	FALSE
57	The Cancer Genome Atlas	Brain Lower Grade Glioma	ABHD12	0.04	0.06	blup	77	0.06	2.2e-07	6.5	6.7	2.4e-11	0.83	0.06	0.94	FALSE
32	GTEx	Pancreas	ENTPD6	0.11	0.05	enet	23	0.05	5.0e-03	6.0	-6.7	2.6e-11	-0.58	0.10	0.83	FALSE
37	GTEx	Testis	ABHD12	0.21	0.18	enet	25	0.23	1.1e-10	6.4	6.7	2.7e-11	0.71	0.07	0.93	FALSE
8	GTEx	Brain Caudate basal ganglia	ABHD12	0.09	0.05	enet	13	0.04	2.9e-02	6.4	6.6	4.2e-11	0.80	0.08	0.77	FALSE
17	GTEx	Cells Transformed fibroblasts	ABHD12	0.24	0.33	lasso	4	0.35	6.3e-27	6.4	6.6	4.7e-11	0.81	0.08	0.92	FALSE
39	GTEx	Thyroid	NINL	0.13	0.18	enet	17	0.20	6.2e-15	-4.3	-6.6	5.0e-11	-0.72	0.52	0.48	FALSE
27	GTEx	Lung	ABHD12	0.06	0.00	lasso	6	0.00	2.7e-01	6.0	6.6	5.1e-11	0.54	0.12	0.65	FALSE
52	The Cancer Genome Atlas	Glioblastoma Multiforme	ABHD12	0.14	0.10	lasso	5	0.13	1.1e-04	6.3	6.5	1.1e-10	0.77	0.06	0.89	FALSE
42	ROSMAP	Brain Pre-frontal Cortex	ABHD12	0.26	0.35	enet	35	0.42	7.9e-58	6.4	6.4	1.2e-10	0.69	0.09	0.91	FALSE
53	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ABHD12	0.04	0.03	blup	77	0.04	4.0e-05	6.6	6.4	1.3e-10	0.86	0.05	0.94	FALSE
35	GTEx	Skin Sun Exposed Lower leg	ABHD12	0.07	0.03	lasso	10	0.05	7.3e-05	5.1	6.4	1.4e-10	0.72	0.14	0.85	FALSE
38	GTEx	Thyroid	ABHD12	0.05	0.04	lasso	5	0.03	3.9e-03	6.4	-6.4	1.4e-10	-0.80	0.09	0.88	FALSE
61	The Cancer Genome Atlas	Prostate Adenocarcinoma	ABHD12	0.03	0.02	lasso	4	0.03	5.8e-04	-6.2	6.4	1.4e-10	0.71	0.07	0.76	FALSE
22	GTEx	Heart Atrial Appendage	ABHD12	0.07	0.06	enet	16	0.06	1.0e-03	6.5	6.4	1.5e-10	0.81	0.08	0.91	FALSE
7	GTEx	Artery Tibial	ABHD12	0.12	0.12	enet	25	0.15	7.1e-12	6.4	6.4	1.6e-10	0.78	0.10	0.90	FALSE
4	GTEx	Adipose Visceral Omentum	ABHD12	0.06	0.00	lasso	8	0.00	4.6e-01	6.4	6.4	1.9e-10	0.65	0.08	0.67	FALSE
25	GTEx	Liver	ABHD12	0.20	0.20	lasso	19	0.15	7.3e-05	6.4	6.3	2.4e-10	0.81	0.09	0.91	FALSE
18	GTEx	Colon Sigmoid	ABHD12	0.17	0.17	lasso	15	0.17	1.0e-06	6.3	6.3	2.8e-10	0.76	0.10	0.90	FALSE
49	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	PYGB	0.08	0.04	blup	74	0.06	1.0e-03	6.4	-6.3	3.0e-10	-0.69	0.04	0.86	FALSE
14	GTEx	Breast Mammary Tissue	ABHD12	0.08	0.09	lasso	5	0.09	3.3e-05	6.4	6.3	3.1e-10	0.69	0.11	0.84	FALSE
55	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ABHD12	0.03	0.01	blup	77	0.01	8.7e-03	4.1	6.2	4.4e-10	0.67	0.06	0.74	FALSE
31	GTEx	Nerve Tibial	ABHD12	0.24	0.44	lasso	11	0.44	5.1e-34	6.4	-6.2	4.8e-10	-0.81	0.09	0.91	FALSE
43	ROSMAP	Brain Pre-frontal Cortex	NINL	0.19	0.19	enet	18	0.25	2.1e-32	6.4	6.2	7.3e-10	0.81	0.07	0.93	FALSE
12	GTEx	Brain Cortex	ABHD12	0.08	0.11	lasso	8	0.09	1.4e-03	6.5	6.2	7.8e-10	0.78	0.07	0.76	FALSE
24	GTEx	Heart Left Ventricle	NINL	0.08	0.03	enet	11	0.05	1.1e-03	6.4	6.1	8.0e-10	0.69	0.14	0.79	FALSE
59	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ABHD12	0.08	0.09	blup	80	0.09	1.7e-06	6.5	6.1	9.1e-10	0.82	0.06	0.94	FALSE
47	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	ABHD12	0.04	0.00	blup	77	0.02	6.6e-03	6.4	6.1	9.5e-10	0.85	0.04	0.53	FALSE
36	GTEx	Spleen	PYGB	0.15	0.09	lasso	6	0.04	2.6e-02	6.4	6.1	1.0e-09	0.84	0.09	0.81	FALSE
65	The Cancer Genome Atlas	Thyroid Carcinoma	NINL	0.08	0.14	lasso	11	0.13	2.9e-12	6.5	-6.1	1.0e-09	-0.80	0.03	0.97	FALSE
58	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ABHD12	0.07	0.05	blup	77	0.05	2.4e-03	6.4	6.0	1.4e-09	0.77	0.05	0.83	FALSE
50	The Cancer Genome Atlas	Colon Adenocarcinoma	NINL	0.20	0.06	lasso	4	0.08	2.7e-05	4.9	6.0	2.2e-09	0.76	0.07	0.86	FALSE
63	The Cancer Genome Atlas	Testicular Germ Cell Tumors	NINL	0.11	0.03	blup	81	0.07	2.1e-03	-6.2	-5.9	3.0e-09	-0.69	0.03	0.66	FALSE
60	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ENTPD6	0.07	0.07	lasso	1	0.04	9.2e-03	5.8	-5.8	6.0e-09	-0.77	0.02	0.79	FALSE
10	GTEx	Brain Cerebellar Hemisphere	ENTPD6	0.22	0.26	lasso	3	0.17	3.8e-05	5.8	-5.8	6.5e-09	-0.77	0.14	0.85	FALSE
48	The Cancer Genome Atlas	Breast Invasive Carcinoma	PYGB	0.08	0.02	enet	7	0.03	1.7e-07	5.5	-5.8	6.8e-09	-0.51	0.81	0.16	FALSE
5	GTEx	Artery Aorta	ABHD12	0.06	0.03	enet	6	0.03	5.4e-03	6.1	5.8	8.0e-09	0.76	0.10	0.85	FALSE
66	The Cancer Genome Atlas	Thyroid Carcinoma	PYGB	0.10	0.08	lasso	7	0.07	1.4e-07	4.9	-5.7	1.0e-08	-0.44	0.82	0.18	FALSE
15	GTEx	Breast Mammary Tissue (Male)	ABHD12	0.06	0.01	lasso	3	0.02	1.3e-01	4.8	5.7	1.1e-08	0.44	0.05	0.16	FALSE
13	GTEx	Breast Mammary Tissue	CST7	0.10	0.00	lasso	4	0.00	7.3e-01	-5.1	5.7	1.3e-08	0.65	0.08	0.66	FALSE
19	GTEx	Esophagus Gastroesophageal Junction	ABHD12	0.15	0.14	lasso	13	0.14	7.0e-06	5.8	5.7	1.3e-08	0.74	0.08	0.92	FALSE
64	The Cancer Genome Atlas	Thyroid Carcinoma	ENTPD6	0.16	0.14	lasso	4	0.13	1.2e-12	5.8	-5.7	1.3e-08	-0.76	0.02	0.98	FALSE
46	YFS	Blood	NINL	0.04	0.03	lasso	8	0.03	2.8e-10	5.7	5.6	1.8e-08	0.60	0.90	0.10	FALSE
3	CommonMind	Brain Pre-frontal Cortex	PYGB	0.10	0.05	lasso	3	0.05	6.9e-07	5.2	-5.6	2.1e-08	-0.48	0.87	0.03	FALSE
21	GTEx	Esophagus Muscularis	ABHD12	0.10	0.10	enet	42	0.09	4.5e-06	6.4	5.6	2.1e-08	0.67	0.08	0.92	FALSE
20	GTEx	Esophagus Mucosa	ENTPD6	0.09	0.04	enet	20	0.06	4.2e-05	6.4	-5.5	2.9e-08	-0.55	0.10	0.90	FALSE
9	GTEx	Brain Cerebellar Hemisphere	PYGB	0.20	0.16	lasso	5	0.12	5.8e-04	5.8	-5.5	3.1e-08	-0.65	0.09	0.74	FALSE
51	The Cancer Genome Atlas	Esophageal Carcinoma	LOC100134868	0.14	0.11	lasso	2	0.10	4.6e-04	-5.6	-5.5	4.5e-08	-0.51	0.00	0.91	FALSE
26	GTEx	Liver	APMAP	0.20	-0.01	lasso	9	0.00	3.8e-01	6.5	5.5	4.9e-08	0.59	0.08	0.62	FALSE
29	GTEx	Muscle Skeletal	ENTPD6	0.04	0.02	lasso	4	0.01	1.5e-02	5.1	-5.5	5.0e-08	-0.74	0.10	0.84	FALSE
54	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	GINS1	0.03	0.01	enet	13	0.02	4.3e-03	3.1	5.4	6.3e-08	0.87	0.03	0.68	FALSE
34	GTEx	Skin Not Sun Exposed Suprapubic	PYGB	0.12	0.13	enet	13	0.14	4.2e-08	4.9	-5.3	1.2e-07	-0.51	0.57	0.26	FALSE
40	GTEx	Thyroid	VN1R108P	0.05	0.01	lasso	2	0.02	1.8e-02	3.0	5.2	1.5e-07	0.80	0.09	0.75	FALSE
56	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	ENTPD6	0.29	0.17	lasso	4	0.18	1.0e-10	4.1	-5.2	2.4e-07	-0.58	0.04	0.96	FALSE
30	GTEx	Nerve Tibial	PYGB	0.26	0.15	enet	11	0.14	5.7e-10	4.7	-5.2	2.5e-07	-0.43	0.97	0.03	FALSE