[Hub]/) : Traits : Leg fat percentage (right) : ← →

chr20:31,981,432-34,737,037

Best TWAS P=4.75e-11 · Best GWAS P=1.24e-10 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
14	GTEx	Esophagus Mucosa	UQCC1	0.13	0.10	enet	10	0.07	1.1e-05	-6.4	6.6	4.8e-11	-0.96	0.02	0.98	TRUE
51	The Cancer Genome Atlas	Brain Lower Grade Glioma	GDF5	0.09	0.11	blup	76	0.12	1.0e-13	-6.3	-6.3	2.7e-10	0.89	0.02	0.98	TRUE
1	CommonMind	Brain Pre-frontal Cortex	PROCR	0.05	0.04	lasso	6	0.03	8.0e-05	-5.5	6.0	1.8e-09	-0.39	0.19	0.76	TRUE
28	GTEx	Small Intestine Terminal Ileum	MAP1LC3A	0.45	0.01	lasso	9	0.05	3.3e-02	-5.6	-5.5	4.3e-08	0.09	0.04	0.72	TRUE
9	GTEx	Cells EBV-transformed lymphocytes	PROCR	0.19	0.05	enet	25	0.09	7.3e-04	-5.5	-5.4	6.5e-08	0.63	0.06	0.46	TRUE
26	GTEx	Skin Sun Exposed Lower leg	MMP24	0.42	0.14	lasso	8	0.14	2.5e-11	-6.2	6.6	4.7e-11	-0.47	0.03	0.97	FALSE
55	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UQCC	0.07	0.08	blup	67	0.07	1.1e-08	-6.2	6.5	8.1e-11	-0.90	0.02	0.98	FALSE
42	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	UQCC	0.03	0.04	blup	67	0.03	2.6e-03	-6.3	6.5	9.7e-11	-0.98	0.02	0.90	FALSE
63	The Cancer Genome Atlas	Soft Tissue Sarcoma	UQCC	0.07	0.06	blup	66	0.07	5.2e-05	-6.2	6.5	1.0e-10	-0.96	0.02	0.98	FALSE
8	GTEx	Breast Mammary Tissue (Male)	UQCC1	0.06	0.04	lasso	1	0.02	1.4e-01	-6.4	6.4	1.2e-10	-1.00	0.03	0.29	FALSE
35	ROSMAP	Brain Pre-frontal Cortex	UQCC1	0.05	0.05	lasso	5	0.06	1.7e-08	-6.4	6.4	1.3e-10	-0.91	0.02	0.98	FALSE
59	The Cancer Genome Atlas	Prostate Adenocarcinoma	GDF5	0.05	0.05	lasso	5	0.04	7.2e-05	-6.3	-6.4	1.9e-10	0.86	0.02	0.98	FALSE
57	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EIF6	0.31	0.11	lasso	6	0.08	2.8e-04	-6.2	-6.3	2.2e-10	0.33	0.01	0.90	FALSE
31	METSIM	Adipose	UQCC1	0.09	0.04	enet	18	0.05	1.5e-07	-6.2	6.3	2.4e-10	-0.98	0.02	0.98	FALSE
54	The Cancer Genome Atlas	Lung Adenocarcinoma	UQCC	0.10	0.07	enet	10	0.07	1.5e-08	-6.4	6.3	2.4e-10	-0.96	0.01	0.99	FALSE
29	GTEx	Stomach	UQCC1	0.09	0.14	lasso	2	0.15	1.9e-07	-6.2	6.3	3.6e-10	-0.95	0.02	0.97	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	MMP24-AS1	0.13	0.04	lasso	6	0.04	3.3e-03	-6.2	6.3	3.9e-10	-0.40	0.06	0.51	FALSE
32	NTR	Blood	EIF6	0.07	0.05	lasso	3	0.05	4.1e-16	-6.2	-6.2	4.1e-10	0.32	0.03	0.97	FALSE
33	NTR	Blood	UQCC	0.01	0.01	enet	6	0.00	1.6e-02	-6.2	6.2	4.1e-10	-0.98	0.02	0.95	FALSE
36	ROSMAP	Brain Pre-frontal Cortex	GDF5	0.10	0.13	lasso	2	0.12	2.9e-15	-6.2	-6.2	4.1e-10	0.99	0.02	0.98	FALSE
53	The Cancer Genome Atlas	Brain Lower Grade Glioma	UQCC	0.04	0.06	lasso	6	0.05	2.3e-06	-6.2	6.2	4.1e-10	-1.00	0.02	0.98	FALSE
22	GTEx	Skin Not Sun Exposed Suprapubic	MMP24	0.30	0.07	lasso	7	0.10	5.6e-06	-6.2	6.2	5.3e-10	-0.41	0.08	0.89	FALSE
56	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	GDF5	0.05	0.02	blup	76	0.04	1.4e-03	-6.2	-6.2	5.7e-10	0.94	0.02	0.95	FALSE
62	The Cancer Genome Atlas	Prostate Adenocarcinoma	UQCC	0.07	0.10	lasso	8	0.11	1.3e-11	-6.3	6.2	6.3e-10	-0.98	0.02	0.98	FALSE
27	GTEx	Skin Sun Exposed Lower leg	MMP24-AS1	0.61	0.13	lasso	17	0.12	4.8e-10	-6.2	6.2	6.4e-10	-0.33	0.03	0.97	FALSE
17	GTEx	Lung	UQCC1	0.13	0.08	lasso	5	0.06	1.0e-05	-6.2	6.2	6.5e-10	-0.99	0.02	0.98	FALSE
3	GTEx	Adipose Subcutaneous	UQCC1	0.09	0.12	lasso	2	0.11	4.5e-09	-6.2	6.2	7.2e-10	-1.00	0.02	0.98	FALSE
40	YFS	Blood	UQCC	0.21	0.19	lasso	26	0.20	6.4e-64	-6.2	6.1	1.4e-09	-0.96	0.02	0.98	FALSE
18	GTEx	Lung	EIF6	0.20	0.10	lasso	6	0.09	3.4e-07	-6.2	-6.0	1.6e-09	0.41	0.04	0.96	FALSE
49	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	UQCC	0.05	0.06	blup	66	0.06	3.6e-07	-5.2	6.0	1.9e-09	-0.95	0.02	0.98	FALSE
46	The Cancer Genome Atlas	Glioblastoma Multiforme	UQCC	0.15	0.02	blup	67	0.04	2.0e-02	-2.9	6.0	2.4e-09	-0.78	0.02	0.50	FALSE
67	The Cancer Genome Atlas	Thyroid Carcinoma	GDF5	0.02	0.00	blup	76	0.00	1.9e-01	-6.4	-5.9	2.9e-09	0.97	0.02	0.90	FALSE
11	GTEx	Cells Transformed fibroblasts	UQCC1	0.23	0.24	lasso	8	0.25	9.4e-19	-6.2	5.9	3.2e-09	-0.98	0.02	0.98	FALSE
7	GTEx	Breast Mammary Tissue	MMP24-AS1	0.15	0.06	enet	10	0.08	7.1e-05	-4.0	5.9	3.5e-09	-0.37	0.15	0.56	FALSE
5	GTEx	Adipose Visceral Omentum	UQCC1	0.15	0.08	lasso	7	0.07	1.6e-04	-6.2	5.8	5.0e-09	-0.96	0.03	0.96	FALSE
66	The Cancer Genome Atlas	Stomach Adenocarcinoma	UQCC	0.07	0.06	lasso	10	0.06	2.8e-05	-5.7	5.8	6.1e-09	-0.96	0.02	0.98	FALSE
69	The Cancer Genome Atlas	Thyroid Carcinoma	UQCC	0.15	0.21	blup	67	0.22	1.2e-20	-6.4	5.8	6.3e-09	-0.94	0.01	0.99	FALSE
6	GTEx	Adrenal Gland	MMP24-AS1	0.18	0.04	enet	10	0.13	2.2e-05	-5.1	5.8	7.5e-09	-0.81	0.14	0.47	FALSE
21	GTEx	Nerve Tibial	UQCC1	0.07	0.04	enet	6	0.03	2.7e-03	-6.2	5.8	8.0e-09	-0.97	0.03	0.96	FALSE
41	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	MMP24	0.10	0.03	enet	14	0.05	5.1e-05	-4.0	5.7	9.4e-09	-0.39	0.10	0.75	FALSE
12	GTEx	Cells Transformed fibroblasts	MMP24	0.11	0.03	enet	11	0.04	8.5e-04	-4.0	5.7	1.4e-08	-0.42	0.31	0.63	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	TRPC4AP	0.05	0.03	lasso	4	0.03	8.7e-05	-5.5	5.6	1.8e-08	-0.25	0.51	0.24	FALSE
19	GTEx	Lung	RP4-614O4.11	0.18	0.04	lasso	6	0.07	8.8e-06	-6.2	-5.6	2.1e-08	0.37	0.07	0.91	FALSE
60	The Cancer Genome Atlas	Prostate Adenocarcinoma	MMP24	0.19	0.21	enet	7	0.24	1.6e-24	-4.0	5.6	2.2e-08	-0.40	0.97	0.03	FALSE
45	The Cancer Genome Atlas	Colon Adenocarcinoma	PROCR	0.09	0.07	lasso	2	0.06	2.0e-04	-5.5	5.6	2.7e-08	-0.26	0.01	0.96	FALSE
44	The Cancer Genome Atlas	Breast Invasive Carcinoma	UQCC	0.08	0.11	blup	67	0.12	1.1e-22	-6.4	5.5	3.0e-08	-0.96	0.02	0.98	FALSE
20	GTEx	Muscle Skeletal	MMP24-AS1	0.27	0.06	lasso	3	0.04	1.3e-04	-4.2	5.5	3.6e-08	-0.41	0.28	0.53	FALSE
58	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	UQCC	0.22	0.21	lasso	7	0.18	1.9e-07	-6.3	5.5	3.6e-08	-0.92	0.02	0.98	FALSE
65	The Cancer Genome Atlas	Stomach Adenocarcinoma	PROCR	0.10	0.06	lasso	3	0.06	2.8e-05	-5.5	5.5	4.0e-08	-0.22	0.01	0.99	FALSE
38	YFS	Blood	EIF6	0.02	0.00	blup	341	0.01	4.1e-05	-2.6	-5.5	4.7e-08	0.39	0.86	0.05	FALSE
37	YFS	Blood	EIF2S2	0.07	0.07	enet	25	0.06	4.3e-20	-5.0	5.4	5.4e-08	-0.04	0.39	0.60	FALSE
2	CommonMind	Brain Pre-frontal Cortex	UQCC	0.07	0.04	lasso	2	0.05	1.4e-06	-5.7	5.4	5.8e-08	-0.93	0.02	0.98	FALSE
52	The Cancer Genome Atlas	Brain Lower Grade Glioma	PROCR	0.10	0.11	lasso	4	0.12	5.5e-13	-5.6	5.4	6.0e-08	-0.25	0.01	0.99	FALSE
61	The Cancer Genome Atlas	Prostate Adenocarcinoma	PROCR	0.04	0.05	lasso	4	0.03	3.6e-04	-5.4	5.4	6.3e-08	-0.24	0.01	0.97	FALSE
68	The Cancer Genome Atlas	Thyroid Carcinoma	PROCR	0.09	0.06	blup	45	0.08	3.0e-08	-5.5	5.4	6.8e-08	-0.33	0.01	0.99	FALSE
48	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EIF6	0.03	0.03	enet	11	0.03	2.4e-04	-4.2	-5.4	7.2e-08	0.17	0.06	0.20	FALSE
10	GTEx	Cells Transformed fibroblasts	PROCR	0.14	0.13	lasso	2	0.11	1.9e-08	-5.4	5.4	7.6e-08	-0.22	0.78	0.22	FALSE
25	GTEx	Skin Sun Exposed Lower leg	UQCC1	0.19	0.13	enet	16	0.10	8.1e-09	-6.2	5.4	7.7e-08	-0.92	0.02	0.98	FALSE
30	GTEx	Whole Blood	MMP24-AS1	0.21	0.07	lasso	5	0.09	1.5e-08	-4.2	5.4	8.1e-08	-0.29	0.56	0.43	FALSE
64	The Cancer Genome Atlas	Stomach Adenocarcinoma	GDF5	0.09	0.04	enet	13	0.05	2.4e-04	-6.3	-5.4	8.1e-08	0.73	0.03	0.93	FALSE
24	GTEx	Skin Not Sun Exposed Suprapubic	RP4-614O4.11	0.26	0.04	lasso	8	0.03	6.9e-03	-4.2	-5.3	1.1e-07	0.42	0.60	0.27	FALSE
13	GTEx	Cells Transformed fibroblasts	MMP24-AS1	0.15	0.04	lasso	2	0.04	8.3e-04	-4.0	5.3	1.3e-07	-0.41	0.44	0.47	FALSE
50	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	UQCC	0.09	0.10	blup	67	0.10	7.2e-11	-6.2	5.3	1.5e-07	-0.96	0.02	0.98	FALSE
43	The Cancer Genome Atlas	Breast Invasive Carcinoma	PROCR	0.05	0.02	blup	44	0.05	1.3e-09	-5.4	5.2	1.9e-07	-0.38	0.01	0.99	FALSE
4	GTEx	Adipose Subcutaneous	MMP24	0.22	0.13	enet	8	0.14	1.7e-11	-4.0	5.2	2.2e-07	-0.40	1.00	0.00	FALSE
39	YFS	Blood	PROCR	0.01	0.00	blup	348	0.01	3.3e-03	-2.4	5.1	2.8e-07	-0.72	0.04	0.89	FALSE
47	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CEP250	0.02	0.01	blup	43	0.02	8.0e-04	-3.7	-5.1	2.9e-07	0.84	0.04	0.77	FALSE
15	GTEx	Esophagus Mucosa	MMP24-AS1	0.32	0.16	lasso	4	0.17	2.9e-11	-4.2	5.1	3.0e-07	-0.29	0.99	0.01	FALSE
16	GTEx	Lung	TRPC4AP	0.07	0.00	lasso	6	0.00	6.6e-01	-5.5	5.1	3.1e-07	-0.29	0.09	0.05	FALSE