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chr5:73,626,450-75,704,085

Best TWAS P=2.28e-18 · Best GWAS P=1.14e-18 conditioned to 0.0469

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
2	CommonMind	Brain Pre-frontal Cortex	POC5	0.17	0.16	lasso	5	0.15	5.2e-18	-8.5	8.7	2.3e-18	-0.90	0.02	0.98	TRUE
1	CommonMind	Brain Pre-frontal Cortex	ANKRD31	0.10	0.13	lasso	9	0.13	3.9e-15	-6.6	6.4	1.3e-10	-0.33	1.00	0.00	TRUE
17	ROSMAP	Brain Pre-frontal Cortex	POLK	0.03	0.01	lasso	7	0.02	3.9e-03	-6.3	-7.9	2.9e-15	0.81	0.28	0.61	FALSE
16	METSIM	Adipose	POLK	0.05	0.01	enet	16	0.03	4.3e-05	-7.1	-7.8	5.1e-15	0.58	0.84	0.14	FALSE
10	GTEx	Spleen	POLK	0.18	-0.01	lasso	16	0.03	5.1e-02	-4.1	-7.4	1.8e-13	0.59	0.13	0.36	FALSE
14	GTEx	Testis	GCNT4	0.42	0.35	enet	62	0.37	3.8e-17	-6.5	-7.2	5.4e-13	0.50	0.23	0.77	FALSE
20	The Cancer Genome Atlas	Brain Lower Grade Glioma	POC5	0.04	0.00	enet	7	0.03	2.1e-04	-8.5	7.2	6.4e-13	-0.77	0.01	0.67	FALSE
4	GTEx	Adrenal Gland	GCNT4	0.13	0.02	lasso	8	0.01	1.3e-01	-5.3	-7.0	2.5e-12	0.49	0.07	0.83	FALSE
6	GTEx	Brain Cerebellar Hemisphere	POLK	0.27	0.20	lasso	6	0.16	8.3e-05	-5.9	-6.9	4.7e-12	0.64	0.26	0.37	FALSE
12	GTEx	Spleen	CTC-366B18.2	0.16	0.11	lasso	3	0.14	2.2e-04	-4.9	-6.7	2.0e-11	0.72	0.05	0.81	FALSE
7	GTEx	Brain Cerebellar Hemisphere	POC5	0.31	0.15	enet	18	0.30	1.6e-08	-4.9	-6.7	2.6e-11	0.61	0.35	0.56	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	ANKDD1B	0.07	0.00	bslmm	382	0.03	7.0e-05	-4.7	6.5	1.1e-10	-0.63	0.06	0.68	FALSE
15	GTEx	Thyroid	CTC-366B18.2	0.06	0.03	lasso	9	0.02	6.2e-03	-6.4	-6.4	1.7e-10	0.62	0.18	0.50	FALSE
21	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	HMGCR	0.04	0.02	enet	4	0.03	6.0e-03	-6.2	-6.1	9.9e-10	0.57	0.02	0.72	FALSE
8	GTEx	Cells Transformed fibroblasts	POLK	0.06	0.04	lasso	3	0.04	1.0e-03	-5.6	6.0	1.9e-09	-0.61	0.15	0.68	FALSE
13	GTEx	Testis	POC5	0.27	0.13	lasso	8	0.09	8.1e-05	-6.2	6.0	2.3e-09	-0.65	0.29	0.61	FALSE
23	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	POC5	0.24	0.13	blup	70	0.14	1.2e-04	-6.6	-6.0	2.3e-09	0.73	0.07	0.73	FALSE
18	ROSMAP	Brain Pre-frontal Cortex	POC5	0.05	0.00	blup	384	0.02	8.6e-04	-5.0	-5.9	3.7e-09	0.57	0.27	0.20	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	POLK	0.03	0.01	blup	53	0.01	1.6e-02	-4.0	5.8	7.1e-09	-0.57	0.30	0.45	FALSE
5	GTEx	Artery Tibial	GCNT4	0.08	0.07	lasso	2	0.04	3.9e-04	-5.3	5.4	7.9e-08	-0.44	0.65	0.11	FALSE
9	GTEx	Esophagus Mucosa	COL4A3BP	0.09	0.06	lasso	5	0.05	4.2e-04	-4.2	5.4	8.5e-08	-0.51	0.40	0.52	FALSE
3	GTEx	Adipose Visceral Omentum	POC5	0.13	0.08	lasso	9	0.08	6.1e-05	-5.0	-5.2	2.0e-07	0.60	0.83	0.06	FALSE
11	GTEx	Spleen	POC5	0.42	0.37	lasso	4	0.34	1.3e-09	-4.9	-5.1	2.9e-07	0.57	0.84	0.14	FALSE