[Hub]/) : Traits : Leg fat mass (right) : ← →

chr2:24,324,172-26,088,769

Best TWAS P=4.13e-38 · Best GWAS P=4.95e-32 conditioned to 0.0517

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ADCY3	0.16	0.12	lasso	10	0.14	3.2e-17	11.48	-12.9	4.1e-38	-0.87	0.01	0.99	TRUE
2	CommonMind	Brain Pre-frontal Cortex	CENPO	0.07	0.03	bslmm	322	0.03	7.0e-05	6.88	-8.3	7.0e-17	-0.49	0.47	0.26	FALSE
3	GTEx	Adipose Subcutaneous	ADCY3	0.07	0.04	lasso	6	0.01	3.2e-02	10.64	10.4	3.4e-25	0.86	0.07	0.91	FALSE
4	GTEx	Adipose Subcutaneous	RP11-443B20.1	0.04	0.00	enet	10	0.00	1.2e-01	6.76	9.2	2.2e-20	0.81	0.04	0.90	FALSE
5	GTEx	Adrenal Gland	PTRHD1	0.32	0.28	lasso	3	0.26	8.3e-10	-4.72	5.2	2.6e-07	0.41	0.98	0.00	FALSE
6	GTEx	Artery Tibial	ADCY3	0.21	0.14	lasso	6	0.15	4.3e-12	10.01	11.1	1.1e-28	0.69	0.98	0.02	FALSE
7	GTEx	Artery Tibial	RP11-443B20.1	0.17	0.08	enet	40	0.09	8.2e-08	10.01	9.6	1.0e-21	0.59	0.48	0.48	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	ADCY3	0.25	0.23	enet	10	0.12	9.2e-05	10.64	-8.8	1.8e-18	-0.84	0.02	0.97	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	RP11-443B20.1	0.13	0.13	enet	9	0.05	9.2e-03	10.64	-10.9	8.3e-28	-0.93	0.01	0.96	FALSE
10	GTEx	Nerve Tibial	ADCY3	0.09	0.05	enet	6	0.03	2.2e-03	10.01	-12.1	1.3e-33	-0.91	0.01	0.99	FALSE
11	GTEx	Nerve Tibial	RP11-443B20.1	0.07	0.03	enet	6	0.02	1.1e-02	10.01	-11.9	2.1e-32	-0.81	0.02	0.97	FALSE
12	GTEx	Whole Blood	DNAJC27	0.08	0.10	lasso	1	0.10	2.2e-09	10.31	10.3	6.2e-25	0.80	0.88	0.12	FALSE
13	GTEx	Whole Blood	ADCY3	0.23	0.24	enet	24	0.27	5.5e-25	10.87	11.8	3.2e-32	0.86	0.95	0.05	FALSE
14	GTEx	Whole Blood	RP11-443B20.1	0.21	0.17	enet	32	0.20	1.8e-18	10.31	12.2	2.5e-34	0.86	0.76	0.24	FALSE
15	METSIM	Adipose	EFR3B	0.04	0.00	bslmm	357	0.00	9.7e-02	-1.21	-7.1	1.0e-12	-0.37	0.06	0.08	FALSE
16	ROSMAP	Brain Pre-frontal Cortex	ADCY3	0.17	0.26	enet	32	0.26	6.8e-33	10.87	-11.7	9.7e-32	-0.89	0.80	0.20	FALSE
17	YFS	Blood	ADCY3	0.07	0.02	bslmm	343	0.04	7.3e-14	11.77	-7.0	1.9e-12	-0.61	0.00	1.00	FALSE
18	YFS	Blood	POMC	0.35	0.05	enet	71	0.19	5.7e-59	-7.35	-6.8	7.4e-12	-0.31	1.00	0.00	FALSE
19	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADCY3	0.05	0.03	blup	81	0.03	5.0e-07	0.19	-5.3	9.6e-08	-0.50	0.60	0.35	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	POMC	0.08	0.05	lasso	3	0.06	2.6e-12	-2.27	-6.1	1.1e-09	-0.20	0.97	0.03	FALSE
21	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	POMC	0.06	0.00	enet	12	0.03	9.3e-05	-2.27	-6.3	3.1e-10	-0.27	0.01	0.41	FALSE
22	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EFR3B	0.03	0.05	lasso	1	0.04	1.9e-05	-8.85	-8.8	8.4e-19	-0.67	0.56	0.06	FALSE
23	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADCY3	0.03	0.02	blup	81	0.02	7.1e-04	6.88	-10.2	2.3e-24	-0.87	0.03	0.94	FALSE
24	The Cancer Genome Atlas	Lung Adenocarcinoma	DNAJC27	0.05	0.01	blup	46	0.04	3.2e-05	2.81	-6.0	2.2e-09	-0.55	0.35	0.59	FALSE
25	The Cancer Genome Atlas	Lung Adenocarcinoma	POMC	0.14	0.04	enet	7	0.08	5.3e-10	-2.27	-7.2	5.0e-13	-0.22	0.38	0.62	FALSE
26	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	POMC	0.19	0.01	blup	38	0.05	1.5e-04	-7.35	-6.3	2.1e-10	-0.33	0.01	0.56	TRUE
27	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	POMC	0.22	0.05	blup	37	0.03	2.1e-02	-3.33	-6.8	8.3e-12	-0.12	0.01	0.29	FALSE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	POMC	0.11	0.08	enet	7	0.09	1.6e-09	-2.27	-6.9	5.7e-12	-0.24	0.92	0.06	FALSE
29	The Cancer Genome Atlas	Stomach Adenocarcinoma	POMC	0.14	0.00	blup	40	0.02	2.2e-02	-3.33	-5.5	2.9e-08	-0.14	0.01	0.18	TRUE