Best TWAS P=3.27e-12 · Best GWAS P=1.2e-09 conditioned to 0.00321
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Liver | PDE6D | 0.21 | 0.10 | lasso | 4 | 0.09 | 1.8e-03 | -5.5 | -5.9 | 4.5e-09 | -0.06 | 0.03 | 0.80 | TRUE |
| 2 | ROSMAP | Brain Pre-frontal Cortex | NCL | 0.16 | 0.05 | lasso | 6 | 0.08 | 6.1e-10 | 3.0 | 5.2 | 2.6e-07 | 0.00 | 0.03 | 0.97 | FALSE |
| 3 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C2orf52 | 0.15 | 0.14 | enet | 8 | 0.13 | 3.7e-11 | -5.3 | 5.2 | 2.5e-07 | 0.02 | 0.01 | 0.99 | FALSE |
| 4 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | C2orf52 | 0.28 | 0.12 | lasso | 6 | 0.12 | 2.0e-06 | -5.5 | 5.5 | 3.4e-08 | 0.04 | 0.00 | 1.00 | FALSE |
| 5 | The Cancer Genome Atlas | Glioblastoma Multiforme | C2orf52 | 0.28 | 0.12 | enet | 12 | 0.18 | 5.0e-06 | -5.0 | 5.2 | 2.7e-07 | 0.07 | 0.02 | 0.92 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | EFHD1 | 0.11 | 0.01 | blup | 70 | 0.03 | 1.0e-02 | 5.5 | 7.0 | 3.3e-12 | -0.61 | 0.01 | 0.85 | TRUE |
| 7 | The Cancer Genome Atlas | Brain Lower Grade Glioma | GIGYF2 | 0.02 | 0.01 | lasso | 3 | 0.01 | 5.3e-02 | -5.6 | -5.6 | 1.7e-08 | 0.91 | 0.04 | 0.83 | FALSE |
| 8 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | C2orf52 | 0.13 | 0.06 | lasso | 4 | 0.05 | 2.1e-03 | -5.3 | 5.2 | 2.5e-07 | 0.01 | 0.01 | 0.89 | FALSE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C2orf52 | 0.28 | 0.18 | lasso | 4 | 0.20 | 3.7e-22 | -5.5 | 5.3 | 1.2e-07 | 0.04 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | KCNJ13 | 0.07 | 0.07 | blup | 36 | 0.06 | 2.4e-03 | -5.7 | 5.2 | 2.5e-07 | -0.86 | 0.02 | 0.83 | FALSE |
| 11 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C2orf52 | 0.27 | 0.27 | lasso | 5 | 0.28 | 1.7e-11 | -5.3 | 5.2 | 1.5e-07 | 0.02 | 0.01 | 0.99 | FALSE |
| 12 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | C2orf52 | 0.21 | 0.20 | lasso | 1 | 0.18 | 1.4e-05 | -5.5 | 5.5 | 4.0e-08 | 0.03 | 0.00 | 0.96 | TRUE |
| 13 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C2orf52 | 0.29 | 0.17 | enet | 10 | 0.19 | 3.2e-07 | -5.3 | 5.3 | 1.1e-07 | 0.03 | 0.00 | 0.99 | FALSE |
| 14 | The Cancer Genome Atlas | Thyroid Carcinoma | KCNJ13 | 0.03 | 0.00 | blup | 35 | 0.01 | 4.3e-02 | 5.6 | -6.6 | 3.4e-11 | 0.86 | 0.01 | 0.55 | FALSE |
| 15 | The Cancer Genome Atlas | Thyroid Carcinoma | NGEF | 0.04 | 0.03 | enet | 7 | 0.03 | 5.6e-04 | 5.7 | -6.4 | 1.2e-10 | 0.76 | 0.01 | 0.98 | FALSE |