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chr2:24,021,231-27,649,375

Best TWAS P=2.67e-61 · Best GWAS P=1.39e-51 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ADCY3	0.16	0.12	lasso	10	0.14	3.2e-17	14.9	-16.5	2.7e-61	-0.87	0.01	0.99	TRUE
15	GTEx	Whole Blood	DNAJC27	0.08	0.10	lasso	1	0.10	2.2e-09	13.6	13.6	6.9e-42	0.80	0.89	0.11	TRUE
9	GTEx	Cells EBV-transformed lymphocytes	ADCY3	0.25	0.23	enet	10	0.12	9.2e-05	13.7	-11.7	8.5e-32	-0.84	0.02	0.97	TRUE
27	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EFR3B	0.03	0.05	lasso	1	0.04	1.9e-05	-11.5	-11.5	1.3e-30	-0.67	0.56	0.06	TRUE
18	METSIM	Adipose	EFR3B	0.04	0.00	bslmm	357	0.00	9.7e-02	-1.8	-8.3	8.3e-17	-0.37	0.06	0.08	TRUE
5	GTEx	Adrenal Gland	PTRHD1	0.32	0.28	lasso	3	0.26	8.3e-10	-7.8	8.3	1.2e-16	0.41	0.98	0.00	TRUE
26	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	POMC	0.06	0.00	enet	12	0.03	9.3e-05	-2.2	-7.8	8.0e-15	-0.27	0.01	0.45	TRUE
33	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	POMC	0.19	0.01	blup	38	0.05	1.5e-04	-9.7	-7.7	1.7e-14	-0.33	0.01	0.66	TRUE
21	ROSMAP	Brain Pre-frontal Cortex	KCNK3	0.24	0.15	lasso	3	0.15	6.5e-19	6.6	-6.7	2.4e-11	0.03	0.00	1.00	TRUE
28	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	POMC	0.16	0.05	blup	39	0.11	2.4e-12	-9.7	-5.3	1.1e-07	-0.22	0.01	0.99	TRUE
14	GTEx	Prostate	EPT1	0.21	-0.01	enet	23	0.00	3.2e-01	-3.5	-5.3	1.4e-07	0.01	0.08	0.06	TRUE
11	GTEx	Esophagus Muscularis	NCOA1	0.11	0.01	enet	9	0.01	5.8e-02	2.4	5.2	1.6e-07	0.45	0.08	0.13	TRUE
12	GTEx	Nerve Tibial	ADCY3	0.09	0.05	enet	6	0.03	2.2e-03	13.4	-15.9	7.7e-57	-0.91	0.01	0.99	FALSE
17	GTEx	Whole Blood	RP11-443B20.1	0.21	0.17	enet	32	0.20	1.8e-18	13.6	15.5	6.3e-54	0.86	0.77	0.23	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	ADCY3	0.17	0.26	enet	32	0.26	6.8e-33	13.9	-15.4	1.1e-53	-0.89	0.84	0.16	FALSE
13	GTEx	Nerve Tibial	RP11-443B20.1	0.07	0.03	enet	6	0.02	1.1e-02	13.4	-15.3	5.6e-53	-0.81	0.02	0.97	FALSE
16	GTEx	Whole Blood	ADCY3	0.23	0.24	enet	24	0.27	5.5e-25	13.9	15.1	1.0e-51	0.86	1.00	0.00	FALSE
7	GTEx	Artery Tibial	ADCY3	0.21	0.14	lasso	6	0.15	4.3e-12	13.4	14.8	7.2e-50	0.69	0.98	0.02	FALSE
10	GTEx	Cells EBV-transformed lymphocytes	RP11-443B20.1	0.13	0.13	enet	9	0.05	9.2e-03	13.7	-14.2	8.3e-46	-0.93	0.01	0.96	FALSE
29	The Cancer Genome Atlas	Brain Lower Grade Glioma	ADCY3	0.03	0.02	blup	81	0.02	7.1e-04	8.7	-13.2	8.5e-40	-0.87	0.03	0.94	FALSE
8	GTEx	Artery Tibial	RP11-443B20.1	0.17	0.08	enet	40	0.09	8.2e-08	13.4	13.1	2.2e-39	0.59	0.48	0.48	FALSE
3	GTEx	Adipose Subcutaneous	ADCY3	0.07	0.04	lasso	6	0.01	3.2e-02	13.7	13.1	5.6e-39	0.86	0.07	0.91	FALSE
2	CommonMind	Brain Pre-frontal Cortex	CENPO	0.07	0.03	bslmm	322	0.03	7.0e-05	9.2	-11.9	1.2e-32	-0.49	0.47	0.26	FALSE
4	GTEx	Adipose Subcutaneous	RP11-443B20.1	0.04	0.00	enet	10	0.00	1.2e-01	8.2	11.1	1.0e-28	0.81	0.04	0.90	FALSE
22	YFS	Blood	ADCY3	0.07	0.02	bslmm	343	0.04	7.3e-14	15.1	-8.6	1.0e-17	-0.61	0.00	1.00	FALSE
30	The Cancer Genome Atlas	Lung Adenocarcinoma	DNAJC27	0.05	0.01	blup	46	0.04	3.2e-05	4.2	-8.3	7.6e-17	-0.55	0.35	0.59	FALSE
23	YFS	Blood	POMC	0.35	0.05	enet	71	0.19	5.7e-59	-9.7	-8.2	2.2e-16	-0.31	1.00	0.00	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	POMC	0.11	0.08	enet	7	0.09	1.6e-09	-2.2	-8.0	1.1e-15	-0.24	0.49	0.50	FALSE
32	The Cancer Genome Atlas	Lung Adenocarcinoma	POMC	0.14	0.04	enet	7	0.08	5.3e-10	-2.2	-7.8	9.1e-15	-0.22	0.28	0.72	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADCY3	0.05	0.03	blup	81	0.03	5.0e-07	1.1	-7.1	1.0e-12	-0.50	0.60	0.35	FALSE
20	ROSMAP	Brain Pre-frontal Cortex	CENPO	0.08	0.04	enet	5	0.05	2.6e-07	-5.6	-7.0	1.9e-12	-0.36	1.00	0.00	FALSE
25	The Cancer Genome Atlas	Breast Invasive Carcinoma	POMC	0.08	0.05	lasso	3	0.06	2.6e-12	-2.2	-7.0	3.4e-12	-0.20	0.90	0.10	FALSE
34	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	POMC	0.22	0.05	blup	37	0.03	2.1e-02	-2.4	-7.0	3.7e-12	-0.12	0.01	0.27	FALSE
6	GTEx	Artery Coronary	DNAJC27	0.12	0.03	lasso	7	0.00	2.4e-01	4.3	6.8	1.2e-11	0.46	0.14	0.22	FALSE
31	The Cancer Genome Atlas	Lung Adenocarcinoma	NCOA1	0.02	0.01	blup	77	0.01	1.2e-02	-4.5	-5.5	4.9e-08	-0.23	0.11	0.04	FALSE
36	The Cancer Genome Atlas	Stomach Adenocarcinoma	POMC	0.14	0.00	blup	40	0.02	2.2e-02	-2.4	-5.2	2.0e-07	-0.14	0.01	0.29	FALSE