Best TWAS P=5.06e-10 · Best GWAS P=3.29e-11 conditioned to 0.142
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | CHMP7 | 0.10 | 0.02 | lasso | 6 | 0.04 | 5.4e-05 | 3.2 | -6.2 | 5.1e-10 | 0.74 | 0.00 | 0.99 | TRUE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | STC1 | 0.04 | 0.05 | enet | 7 | 0.06 | 8.9e-12 | -5.9 | 5.9 | 3.3e-09 | -0.05 | 0.01 | 0.99 | TRUE |
| 4 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | LOXL2 | 0.16 | 0.03 | lasso | 4 | 0.05 | 1.2e-03 | -4.8 | 5.3 | 1.2e-07 | -0.15 | 0.12 | 0.04 | TRUE |
| 2 | YFS | Blood | R3HCC1 | 0.03 | 0.01 | lasso | 6 | 0.01 | 5.3e-04 | -5.8 | 5.6 | 1.8e-08 | -0.73 | 0.02 | 0.97 | FALSE |
| 5 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CHMP7 | 0.03 | 0.03 | blup | 89 | 0.01 | 3.8e-02 | 3.2 | -5.6 | 2.5e-08 | 0.51 | 0.07 | 0.06 | FALSE |
| 1 | GTEx | Cells Transformed fibroblasts | SLC25A37 | 0.13 | 0.05 | lasso | 5 | 0.04 | 3.0e-04 | -5.1 | 5.2 | 1.8e-07 | -0.12 | 0.49 | 0.34 | FALSE |