Best TWAS P=2.44e-29 · Best GWAS P=9.23e-44 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | C18orf8 | 0.26 | 0.35 | lasso | 6 | 0.40 | 1.9e-52 | -8.8 | -8.7 | 3.0e-18 | 0.22 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | NPC1 | 0.08 | 0.07 | lasso | 3 | 0.08 | 5.2e-10 | 6.9 | -5.9 | 3.6e-09 | 0.12 | 1.00 | 0.00 | FALSE |
| 3 | CommonMind | Brain Pre-frontal Cortex | RIOK3 | 0.02 | 0.01 | bslmm | 348 | 0.00 | 1.8e-01 | -7.9 | -10.6 | 4.3e-26 | 0.44 | 0.14 | 0.05 | FALSE |
| 4 | GTEx | Adipose Subcutaneous | TMEM241 | 0.07 | 0.00 | enet | 12 | 0.01 | 4.1e-02 | -7.0 | -6.9 | 5.1e-12 | 0.33 | 0.32 | 0.12 | FALSE |
| 5 | GTEx | Adipose Subcutaneous | C18orf8 | 0.17 | 0.16 | enet | 13 | 0.16 | 2.6e-13 | -8.7 | -9.0 | 3.4e-19 | 0.23 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Adipose Subcutaneous | NPC1 | 0.27 | 0.27 | enet | 12 | 0.30 | 2.4e-25 | -8.3 | -8.3 | 8.3e-17 | 0.25 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Adipose Visceral Omentum | C18orf8 | 0.18 | 0.11 | enet | 10 | 0.04 | 4.5e-03 | -8.8 | -8.9 | 6.4e-19 | 0.30 | 0.85 | 0.01 | FALSE |
| 8 | GTEx | Adipose Visceral Omentum | NPC1 | 0.20 | 0.19 | lasso | 3 | 0.17 | 2.9e-09 | -8.3 | -8.2 | 2.4e-16 | 0.24 | 1.00 | 0.00 | FALSE |
| 9 | GTEx | Artery Tibial | C18orf8 | 0.18 | 0.12 | lasso | 3 | 0.10 | 1.5e-08 | 6.8 | -6.7 | 1.5e-11 | 0.14 | 1.00 | 0.00 | TRUE |
| 10 | GTEx | Artery Tibial | NPC1 | 0.26 | 0.07 | enet | 31 | 0.11 | 3.7e-09 | 6.8 | -5.6 | 1.7e-08 | 0.02 | 1.00 | 0.00 | FALSE |
| 11 | GTEx | Brain Caudate basal ganglia | C18orf8 | 0.15 | 0.16 | enet | 11 | 0.11 | 5.9e-04 | -8.8 | -8.7 | 3.0e-18 | 0.22 | 0.44 | 0.04 | FALSE |
| 12 | GTEx | Brain Cerebellar Hemisphere | RBBP8 | 0.22 | 0.16 | enet | 20 | 0.13 | 3.0e-04 | -4.6 | 5.4 | 7.7e-08 | -0.32 | 0.17 | 0.10 | TRUE |
| 13 | GTEx | Brain Cerebellar Hemisphere | C18orf8 | 0.27 | 0.34 | enet | 19 | 0.34 | 1.3e-09 | -8.8 | -9.0 | 2.4e-19 | 0.24 | 0.96 | 0.00 | FALSE |
| 14 | GTEx | Brain Cerebellum | C18orf8 | 0.23 | 0.18 | enet | 13 | 0.21 | 9.9e-07 | -8.7 | -9.1 | 9.0e-20 | 0.26 | 0.82 | 0.04 | TRUE |
| 15 | GTEx | Brain Cerebellum | NPC1 | 0.20 | 0.10 | enet | 9 | 0.12 | 1.9e-04 | -8.7 | -7.5 | 4.7e-14 | 0.23 | 0.42 | 0.05 | FALSE |
| 16 | GTEx | Brain Cortex | TMEM241 | 0.37 | 0.12 | enet | 19 | 0.22 | 1.3e-06 | 3.1 | -7.0 | 1.8e-12 | 0.26 | 0.67 | 0.04 | FALSE |
| 17 | GTEx | Brain Cortex | C18orf8 | 0.19 | 0.18 | lasso | 5 | 0.13 | 1.8e-04 | -8.8 | -8.8 | 1.2e-18 | 0.23 | 0.48 | 0.03 | TRUE |
| 18 | GTEx | Brain Frontal Cortex BA9 | C18orf8 | 0.42 | 0.30 | enet | 12 | 0.08 | 3.4e-03 | -8.7 | -8.4 | 6.2e-17 | 0.22 | 0.90 | 0.01 | FALSE |
| 19 | GTEx | Brain Nucleus accumbens basal ganglia | TMEM241 | 0.17 | 0.02 | lasso | 6 | -0.01 | 5.6e-01 | -8.7 | -7.3 | 2.1e-13 | 0.24 | 0.10 | 0.06 | TRUE |
| 20 | GTEx | Breast Mammary Tissue | NPC1 | 0.27 | 0.13 | enet | 27 | 0.19 | 5.0e-10 | -8.3 | -8.3 | 1.5e-16 | 0.22 | 1.00 | 0.00 | FALSE |
| 21 | GTEx | Breast Mammary Tissue (Female) | NPC1 | 0.43 | 0.24 | lasso | 3 | 0.27 | 1.1e-08 | -8.3 | -8.6 | 9.3e-18 | 0.26 | 0.98 | 0.00 | FALSE |
| 22 | GTEx | Esophagus Gastroesophageal Junction | NPC1 | 0.19 | 0.13 | lasso | 5 | 0.11 | 1.1e-04 | -4.0 | -5.4 | 5.3e-08 | 0.13 | 0.44 | 0.09 | FALSE |
| 23 | GTEx | Esophagus Mucosa | NPC1 | 0.09 | 0.04 | lasso | 3 | 0.05 | 1.5e-04 | -8.3 | -9.2 | 2.3e-20 | 0.30 | 0.57 | 0.02 | TRUE |
| 24 | GTEx | Esophagus Muscularis | C18orf8 | 0.14 | 0.13 | lasso | 3 | 0.10 | 8.0e-07 | 6.9 | -7.7 | 1.1e-14 | 0.17 | 0.96 | 0.00 | FALSE |
| 25 | GTEx | Esophagus Muscularis | NPC1 | 0.11 | 0.07 | enet | 4 | 0.09 | 7.3e-06 | -8.8 | -9.0 | 1.7e-19 | 0.25 | 0.76 | 0.01 | FALSE |
| 26 | GTEx | Heart Left Ventricle | NPC1 | 0.19 | 0.15 | enet | 12 | 0.17 | 1.6e-09 | -8.7 | -8.5 | 1.4e-17 | 0.26 | 1.00 | 0.00 | FALSE |
| 27 | GTEx | Lung | NPC1 | 0.11 | 0.06 | enet | 11 | 0.04 | 2.3e-04 | -8.9 | -8.2 | 3.1e-16 | 0.21 | 0.99 | 0.00 | FALSE |
| 28 | GTEx | Nerve Tibial | TMEM241 | 0.16 | 0.04 | enet | 10 | 0.07 | 1.8e-05 | -7.8 | -9.7 | 3.3e-22 | 0.48 | 0.70 | 0.02 | FALSE |
| 29 | GTEx | Nerve Tibial | C18orf8 | 0.16 | 0.07 | enet | 21 | 0.09 | 3.9e-07 | -8.3 | -7.3 | 2.5e-13 | 0.12 | 1.00 | 0.00 | FALSE |
| 30 | GTEx | Nerve Tibial | NPC1 | 0.19 | 0.12 | lasso | 6 | 0.16 | 1.1e-11 | 6.9 | -8.3 | 1.5e-16 | 0.21 | 1.00 | 0.00 | FALSE |
| 31 | GTEx | Pancreas | NPC1 | 0.33 | 0.14 | lasso | 7 | 0.12 | 1.1e-05 | -8.7 | -8.4 | 5.6e-17 | 0.24 | 0.81 | 0.01 | FALSE |
| 32 | GTEx | Skin Not Sun Exposed Suprapubic | C18orf8 | 0.21 | 0.27 | enet | 6 | 0.23 | 6.9e-13 | -8.7 | -8.9 | 7.1e-19 | 0.24 | 1.00 | 0.00 | FALSE |
| 33 | GTEx | Skin Not Sun Exposed Suprapubic | NPC1 | 0.15 | 0.08 | lasso | 4 | 0.12 | 2.3e-07 | -8.8 | -8.7 | 2.8e-18 | 0.23 | 0.99 | 0.00 | FALSE |
| 34 | GTEx | Skin Sun Exposed Lower leg | C18orf8 | 0.35 | 0.33 | enet | 23 | 0.36 | 1.7e-30 | -8.8 | -8.7 | 4.6e-18 | 0.24 | 1.00 | 0.00 | FALSE |
| 35 | GTEx | Skin Sun Exposed Lower leg | NPC1 | 0.23 | 0.18 | lasso | 3 | 0.27 | 1.8e-22 | -8.3 | -8.3 | 8.7e-17 | 0.23 | 1.00 | 0.00 | FALSE |
| 36 | GTEx | Testis | C18orf8 | 0.12 | 0.07 | lasso | 6 | 0.08 | 1.9e-04 | -8.8 | -11.2 | 2.4e-29 | 0.43 | 0.16 | 0.50 | TRUE |
| 37 | GTEx | Thyroid | NPC1 | 0.20 | 0.10 | enet | 25 | 0.13 | 2.3e-10 | -8.7 | -6.7 | 1.9e-11 | 0.10 | 1.00 | 0.00 | FALSE |
| 38 | GTEx | Vagina | NPC1 | 0.27 | 0.09 | lasso | 7 | 0.14 | 4.9e-04 | -6.9 | -7.9 | 2.6e-15 | 0.37 | 0.23 | 0.11 | FALSE |
| 39 | METSIM | Adipose | C18orf8 | 0.08 | 0.02 | enet | 23 | 0.04 | 1.0e-06 | 6.9 | -7.1 | 1.1e-12 | 0.26 | 0.80 | 0.01 | FALSE |
| 40 | METSIM | Adipose | NPC1 | 0.06 | 0.05 | enet | 18 | 0.05 | 6.4e-08 | -8.8 | -7.6 | 2.1e-14 | 0.22 | 1.00 | 0.00 | FALSE |
| 41 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NPC1 | 0.03 | 0.03 | blup | 69 | 0.04 | 2.9e-09 | -8.7 | -7.5 | 4.7e-14 | 0.24 | 0.02 | 0.98 | FALSE |
| 42 | The Cancer Genome Atlas | Esophageal Carcinoma | NPC1 | 0.16 | 0.10 | lasso | 3 | 0.10 | 3.7e-04 | 6.9 | -7.8 | 9.1e-15 | 0.19 | 0.05 | 0.65 | FALSE |
| 43 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | NPC1 | 0.05 | 0.02 | blup | 66 | 0.03 | 1.4e-04 | -8.2 | -6.2 | 6.2e-10 | 0.24 | 0.20 | 0.52 | FALSE |
| 44 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | NPC1 | 0.03 | 0.04 | lasso | 2 | 0.05 | 4.2e-06 | -8.2 | -8.8 | 1.7e-18 | 0.27 | 0.02 | 0.98 | FALSE |
| 45 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C18orf45 | 0.04 | 0.02 | lasso | 3 | 0.03 | 2.7e-04 | 6.2 | -7.5 | 8.4e-14 | 0.34 | 0.70 | 0.02 | FALSE |
| 46 | The Cancer Genome Atlas | Brain Lower Grade Glioma | C18orf8 | 0.07 | 0.05 | lasso | 5 | 0.03 | 9.5e-05 | 6.8 | -6.9 | 3.7e-12 | 0.15 | 0.28 | 0.69 | FALSE |
| 47 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CABLES1 | 0.06 | 0.02 | enet | 12 | 0.04 | 6.8e-05 | 3.9 | -7.0 | 2.0e-12 | 0.26 | 0.07 | 0.03 | TRUE |
| 48 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NPC1 | 0.07 | 0.08 | lasso | 3 | 0.10 | 1.6e-11 | 6.8 | -8.4 | 3.1e-17 | 0.20 | 0.05 | 0.95 | TRUE |
| 49 | The Cancer Genome Atlas | Prostate Adenocarcinoma | NPC1 | 0.05 | 0.02 | blup | 65 | 0.03 | 9.9e-04 | -8.2 | -6.9 | 3.9e-12 | 0.25 | 0.03 | 0.66 | FALSE |
| 50 | The Cancer Genome Atlas | Soft Tissue Sarcoma | C18orf45 | 0.08 | 0.06 | blup | 114 | 0.06 | 1.7e-04 | -8.4 | -6.0 | 2.6e-09 | 0.21 | 0.60 | 0.02 | FALSE |
| 51 | The Cancer Genome Atlas | Stomach Adenocarcinoma | NPC1 | 0.06 | 0.01 | enet | 6 | 0.05 | 2.2e-04 | -6.3 | -6.2 | 6.0e-10 | 0.29 | 0.07 | 0.38 | FALSE |
| 52 | The Cancer Genome Atlas | Thyroid Carcinoma | NPC1 | 0.04 | 0.03 | blup | 70 | 0.05 | 9.4e-06 | -8.8 | -7.3 | 3.5e-13 | 0.21 | 0.02 | 0.97 | TRUE |