[Hub]/) : Traits : Arm fat percentage (left) :

chr15:65,989,359-68,789,191

Best TWAS P=6.46e-19 · Best GWAS P=1.83e-20 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex AAGAB 0.06 0.05 enet 11 0.05 3.2e-07 -6.6 -6.5 1.1e-10 0.45 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex IQCH 0.13 0.11 bslmm 597 0.10 5.9e-12 -6.5 6.1 7.8e-10 -0.40 1.00 0.00 FALSE
3 CommonMind Brain Pre-frontal Cortex MAP2K5 0.11 0.07 bslmm 474 0.08 1.2e-09 -8.1 7.3 3.2e-13 -0.74 0.49 0.51 FALSE
4 GTEx Adipose Subcutaneous MAP2K5 0.14 0.18 lasso 4 0.18 1.0e-14 -8.1 8.1 3.7e-16 -0.82 0.98 0.02 FALSE
5 GTEx Adipose Visceral Omentum MAP2K5 0.07 0.08 lasso 3 0.05 1.0e-03 -8.3 8.6 6.8e-18 -0.83 0.02 0.96 FALSE
6 GTEx Artery Aorta MAP2K5 0.06 0.05 enet 6 0.05 7.7e-04 -8.1 8.3 1.2e-16 -0.83 0.12 0.81 FALSE
7 GTEx Artery Coronary MAP2K5 0.11 0.00 enet 28 0.03 4.5e-02 -6.5 7.0 2.4e-12 -0.61 0.09 0.36 FALSE
8 GTEx Artery Tibial MAP2K5 0.15 0.18 lasso 3 0.18 6.3e-14 -8.1 8.3 1.1e-16 -0.81 0.87 0.13 FALSE
9 GTEx Brain Cerebellum MAP2K5 0.27 0.12 lasso 5 0.14 7.9e-05 -6.3 7.5 7.2e-14 -0.69 0.30 0.42 FALSE
10 GTEx Brain Hippocampus IQCH-AS1 0.20 0.08 enet 11 0.05 2.2e-02 3.9 -6.0 1.9e-09 0.47 0.16 0.16 FALSE
11 GTEx Breast Mammary Tissue MAP2K5 0.14 0.07 lasso 5 0.09 2.8e-05 -9.0 7.7 1.1e-14 -0.89 0.03 0.97 FALSE
12 GTEx Cells Transformed fibroblasts SMAD3 0.12 0.01 lasso 9 0.06 3.6e-05 -1.6 -6.1 1.1e-09 0.19 0.25 0.03 TRUE
13 GTEx Esophagus Muscularis MAP2K5 0.24 0.14 lasso 4 0.13 2.1e-08 -8.1 8.2 1.9e-16 -0.82 0.95 0.05 FALSE
14 GTEx Heart Atrial Appendage MAP2K5 0.16 0.08 lasso 5 0.16 1.3e-07 -8.0 8.1 8.2e-16 -0.78 0.07 0.93 FALSE
15 GTEx Heart Left Ventricle MAP2K5 0.10 0.10 lasso 3 0.10 9.4e-06 -8.1 8.1 5.2e-16 -0.84 0.43 0.53 FALSE
16 GTEx Lung MAP2K5 0.12 0.09 enet 11 0.07 3.6e-06 -8.0 7.4 1.1e-13 -0.76 0.68 0.30 FALSE
17 GTEx Muscle Skeletal MAP2K5 0.08 0.03 lasso 6 0.05 1.9e-05 6.3 8.5 2.1e-17 -0.69 0.04 0.96 TRUE
18 GTEx Nerve Tibial MAP2K5 0.19 0.21 lasso 2 0.20 3.3e-14 -8.1 8.1 5.1e-16 -0.82 0.95 0.05 FALSE
19 GTEx Ovary MAP2K5 0.19 0.24 lasso 3 0.21 8.3e-06 -8.1 8.2 2.4e-16 -0.81 0.07 0.83 FALSE
20 GTEx Skin Sun Exposed Lower leg MAP2K5 0.13 0.06 lasso 4 0.09 4.4e-08 3.9 6.7 2.6e-11 -0.68 0.88 0.12 TRUE
21 GTEx Spleen MAP2K5 0.25 0.19 lasso 3 0.18 2.1e-05 -8.1 6.9 6.3e-12 -0.80 0.06 0.88 FALSE
22 GTEx Thyroid MAP2K5 0.11 0.16 lasso 4 0.15 9.6e-12 -8.1 8.3 1.1e-16 -0.82 0.82 0.18 FALSE
23 GTEx Whole Blood MAP2K5 0.09 0.06 lasso 6 0.06 8.1e-06 -8.1 8.9 6.5e-19 -0.79 0.55 0.36 TRUE
24 METSIM Adipose IQCH 0.04 0.02 bslmm 593 0.02 3.3e-04 -1.7 5.3 1.3e-07 -0.09 0.47 0.22 TRUE
25 METSIM Adipose MAP2K5 0.07 0.05 enet 19 0.06 2.8e-09 -9.0 8.2 2.8e-16 -0.87 0.02 0.98 TRUE
26 NTR Blood MAP2K5 0.02 0.00 enet 13 0.01 5.7e-04 -7.9 6.7 2.4e-11 -0.74 0.22 0.74 FALSE
27 YFS Blood MAP2K1 0.07 0.05 lasso 3 0.05 2.0e-17 -5.6 6.0 2.5e-09 -0.07 0.02 0.98 TRUE
28 YFS Blood MAP2K5 0.05 0.07 lasso 4 0.07 1.2e-21 -8.1 7.9 2.0e-15 -0.82 0.99 0.01 FALSE
29 The Cancer Genome Atlas Bladder Urothelial Carcinoma IQCH 0.13 0.07 blup 112 0.10 5.2e-09 -4.9 6.1 1.4e-09 -0.25 0.99 0.00 FALSE
30 The Cancer Genome Atlas Breast Invasive Carcinoma IQCH 0.06 0.05 blup 112 0.06 5.2e-12 -6.4 7.7 1.0e-14 -0.49 0.99 0.01 FALSE
31 The Cancer Genome Atlas Colon Adenocarcinoma IQCH 0.08 0.02 blup 111 0.05 4.2e-04 -4.9 6.1 9.2e-10 -0.47 0.41 0.13 FALSE
32 The Cancer Genome Atlas Glioblastoma Multiforme IQCH 0.19 0.14 enet 21 0.12 2.4e-04 -4.9 7.0 1.9e-12 -0.59 0.11 0.79 FALSE
33 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma IQCH 0.06 0.04 blup 111 0.03 1.0e-04 -4.9 6.6 3.4e-11 -0.33 0.49 0.05 FALSE
34 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma IQCH 0.12 0.10 enet 22 0.12 4.0e-13 -4.8 6.4 1.6e-10 -0.30 1.00 0.00 FALSE
35 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma MAP2K5 0.03 0.03 blup 142 0.02 1.6e-03 -8.1 7.6 4.0e-14 -0.90 0.04 0.93 FALSE
36 The Cancer Genome Atlas Brain Lower Grade Glioma IQCH 0.05 0.04 blup 111 0.04 7.7e-06 -4.9 6.8 9.7e-12 -0.40 0.65 0.24 FALSE
37 The Cancer Genome Atlas Liver Hepatocellular Carcinoma IQCH 0.10 0.01 blup 111 0.03 1.4e-02 6.0 7.0 2.9e-12 -0.31 0.04 0.28 FALSE
38 The Cancer Genome Atlas Lung Adenocarcinoma IQCH 0.04 0.02 enet 8 0.01 1.6e-02 -6.4 7.4 1.6e-13 -0.42 0.12 0.12 FALSE
39 The Cancer Genome Atlas Lung Adenocarcinoma MAP2K5 0.04 0.04 lasso 3 0.03 8.7e-05 -8.1 8.3 1.4e-16 -0.84 0.07 0.91 FALSE
40 The Cancer Genome Atlas Lung Squamous Cell Carcinoma IQCH 0.04 0.02 enet 6 0.03 1.6e-04 -8.3 8.1 4.8e-16 -0.73 0.01 0.98 FALSE
41 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma IQCH 0.11 0.10 blup 112 0.10 2.3e-07 -6.3 7.3 3.7e-13 -0.57 0.06 0.94 FALSE
42 The Cancer Genome Atlas Pancreatic Adenocarcinoma IQCH 0.35 0.04 blup 112 0.12 1.5e-05 -4.9 8.0 1.8e-15 -0.40 0.37 0.23 FALSE
43 The Cancer Genome Atlas Prostate Adenocarcinoma IQCH 0.19 0.07 blup 111 0.16 7.4e-17 -2.6 6.4 2.0e-10 -0.21 1.00 0.00 FALSE
44 The Cancer Genome Atlas Stomach Adenocarcinoma IQCH 0.08 0.03 blup 111 0.04 9.2e-04 -4.9 7.0 2.1e-12 -0.39 0.09 0.08 TRUE
45 The Cancer Genome Atlas Thyroid Carcinoma IQCH 0.15 0.17 enet 19 0.17 1.3e-16 -4.8 6.3 3.3e-10 -0.47 1.00 0.00 FALSE
46 The Cancer Genome Atlas Thyroid Carcinoma LBXCOR1 0.06 0.01 lasso 3 0.03 7.0e-04 -4.9 5.6 1.9e-08 -0.62 0.09 0.53 FALSE
47 The Cancer Genome Atlas Thyroid Carcinoma MAP2K5 0.10 0.06 lasso 5 0.04 6.1e-05 -8.1 8.0 1.1e-15 -0.86 0.46 0.51 FALSE