[Hub]/) : Traits : Arm fat-free mass (left) : ← →

chr12:109,591,369-113,517,494

Best TWAS P=5.26e-17 · Best GWAS P=2.73e-23 conditioned to 0.552

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
4	GTEx	Artery Tibial	HECTD4	0.05	0.02	lasso	3	0.01	3.1e-02	-8.66	-8.4	5.3e-17	0.78	0.02	0.92	TRUE
7	GTEx	Breast Mammary Tissue (Female)	VPS29	0.10	-0.01	lasso	2	0.02	1.0e-01	-5.35	6.7	2.9e-11	-0.33	0.03	0.16	TRUE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	CUX2	0.08	0.01	blup	95	0.02	1.3e-03	4.97	6.4	1.3e-10	-0.14	0.17	0.03	TRUE
1	GTEx	Adipose Subcutaneous	HECTD4	0.06	0.00	enet	15	0.02	1.0e-02	3.58	-6.9	4.5e-12	0.65	0.06	0.84	FALSE
29	YFS	Blood	SH2B3	0.05	0.01	enet	22	0.02	3.3e-07	3.52	-6.7	2.0e-11	0.64	0.67	0.33	FALSE
2	GTEx	Adrenal Gland	PPTC7	0.13	-0.01	lasso	6	0.00	3.4e-01	5.48	6.6	3.5e-11	-0.25	0.04	0.13	FALSE
20	GTEx	Skin Sun Exposed Lower leg	ALDH2	0.10	0.09	enet	13	0.13	6.7e-11	3.39	-6.5	5.8e-11	0.63	0.91	0.09	FALSE
26	NTR	Blood	ALDH2	0.06	0.01	blup	222	0.02	4.3e-08	4.57	6.4	1.4e-10	-0.44	0.93	0.07	FALSE
27	NTR	Blood	GPN3	0.03	0.01	blup	236	0.02	2.7e-06	4.90	-6.3	2.2e-10	0.11	0.52	0.47	FALSE
10	GTEx	Colon Transverse	FAM109A	0.21	0.00	lasso	4	0.01	1.3e-01	5.72	-6.3	2.6e-10	0.41	0.06	0.06	FALSE
16	GTEx	Nerve Tibial	HECTD4	0.05	0.01	enet	6	0.01	3.6e-02	6.16	-6.3	2.8e-10	0.42	0.22	0.46	FALSE
33	The Cancer Genome Atlas	Brain Lower Grade Glioma	ACAD10	0.02	0.02	lasso	3	0.01	7.0e-03	6.18	6.2	7.2e-10	-0.51	0.01	0.90	FALSE
17	GTEx	Skin Not Sun Exposed Suprapubic	VPS29	0.06	0.01	lasso	3	0.01	6.9e-02	5.53	6.0	2.0e-09	-0.06	0.09	0.27	FALSE
23	GTEx	Thyroid	BRAP	0.07	0.02	lasso	7	0.03	1.1e-03	3.52	5.8	7.3e-09	-0.54	0.36	0.43	FALSE
31	The Cancer Genome Atlas	Breast Invasive Carcinoma	VPS29	0.02	0.02	lasso	5	0.03	4.6e-06	5.30	5.7	1.1e-08	-0.07	0.01	0.98	FALSE
24	GTEx	Thyroid	VPS29	0.07	0.01	lasso	5	0.01	8.9e-02	5.30	5.7	1.2e-08	-0.11	0.10	0.11	FALSE
3	GTEx	Artery Tibial	VPS29	0.05	0.03	lasso	3	0.02	5.9e-03	5.67	5.7	1.3e-08	-0.11	0.21	0.23	FALSE
14	GTEx	Muscle Skeletal	IFT81	0.08	0.08	lasso	5	0.07	1.7e-07	5.56	5.7	1.4e-08	-0.03	0.02	0.98	FALSE
32	The Cancer Genome Atlas	Colon Adenocarcinoma	ALDH2	0.07	0.03	lasso	4	0.06	3.9e-04	3.44	-5.7	1.6e-08	0.45	0.02	0.87	FALSE
30	YFS	Blood	TRAFD1	0.04	0.02	lasso	2	0.01	2.9e-05	-4.45	-5.6	1.7e-08	0.54	0.09	0.85	FALSE
13	GTEx	Muscle Skeletal	VPS29	0.06	0.06	lasso	3	0.05	4.3e-06	5.67	5.6	1.9e-08	-0.09	0.37	0.62	FALSE
15	GTEx	Muscle Skeletal	ANAPC7	0.08	0.01	lasso	3	0.00	1.1e-01	4.90	5.6	1.9e-08	-0.07	0.03	0.76	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	VPS29	0.06	0.06	enet	7	0.06	2.1e-07	5.43	5.6	2.1e-08	-0.06	0.01	0.99	FALSE
28	YFS	Blood	GLTP	0.05	0.01	enet	14	0.04	1.5e-13	4.50	5.6	2.5e-08	-0.08	0.02	0.98	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	ARPC3	0.13	0.09	lasso	4	0.04	2.0e-02	5.56	-5.5	2.9e-08	0.03	0.13	0.18	FALSE
6	GTEx	Breast Mammary Tissue (Male)	RP3-462E2.3	0.12	0.03	lasso	7	0.04	4.0e-02	3.88	5.5	3.5e-08	-0.39	0.02	0.06	FALSE
18	GTEx	Skin Sun Exposed Lower leg	ARPC3	0.13	0.15	lasso	3	0.15	1.9e-12	5.47	-5.5	4.5e-08	0.04	0.47	0.53	FALSE
37	The Cancer Genome Atlas	Thyroid Carcinoma	RAD9B	0.10	0.06	enet	5	0.06	1.2e-06	5.47	5.5	4.5e-08	-0.04	0.01	0.99	FALSE
22	GTEx	Testis	ARPC3	0.16	0.16	lasso	3	0.14	7.5e-07	5.46	-5.5	4.8e-08	0.04	0.45	0.54	FALSE
9	GTEx	Cells Transformed fibroblasts	VPS29	0.09	0.13	lasso	3	0.13	9.8e-10	5.67	5.4	5.3e-08	-0.09	0.37	0.63	FALSE
35	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ERP29	0.11	0.03	blup	25	0.05	5.0e-03	3.54	5.4	5.3e-08	-0.60	0.01	0.75	FALSE
25	GTEx	Whole Blood	GPN3	0.19	0.20	lasso	4	0.19	1.9e-17	5.30	-5.4	6.5e-08	0.10	0.61	0.39	FALSE
11	GTEx	Esophagus Mucosa	VPS29	0.14	0.13	lasso	6	0.13	3.0e-09	4.96	5.3	1.0e-07	-0.07	0.59	0.41	FALSE
21	GTEx	Spleen	VPS29	0.24	0.01	enet	14	0.04	2.9e-02	4.71	5.3	1.4e-07	-0.01	0.08	0.13	FALSE
12	GTEx	Heart Left Ventricle	ADAM1A	0.20	0.07	enet	22	0.10	4.3e-06	0.95	5.2	2.0e-07	-0.34	0.35	0.15	FALSE
5	GTEx	Brain Cerebellum	HECTD4	0.25	-0.01	enet	24	0.06	7.7e-03	1.43	-5.2	2.2e-07	0.42	0.06	0.71	FALSE
19	GTEx	Skin Sun Exposed Lower leg	VPS29	0.05	0.04	lasso	6	0.03	1.0e-03	4.62	5.2	2.6e-07	-0.10	0.29	0.18	FALSE