Best TWAS P=6.06e-28 · Best GWAS P=1.19e-33 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | NF1 | 0.06 | 0.01 | blup | 410 | 0.04 | 1.1e-05 | 7.29 | 6.4 | 1.7e-10 | -0.20 | 0.95 | 0.00 | FALSE |
2 | GTEx | Adipose Visceral Omentum | TEFM | 0.12 | 0.02 | lasso | 14 | 0.05 | 1.0e-03 | 0.92 | -5.8 | 5.5e-09 | 0.21 | 0.08 | 0.09 | FALSE |
3 | GTEx | Artery Aorta | ABHD15 | 0.20 | 0.03 | enet | 36 | 0.06 | 2.9e-04 | -4.83 | -7.7 | 1.2e-14 | 0.08 | 0.03 | 0.54 | TRUE |
4 | GTEx | Artery Aorta | TEFM | 0.13 | 0.02 | enet | 34 | 0.03 | 5.8e-03 | 0.94 | -6.3 | 2.2e-10 | 0.57 | 0.15 | 0.78 | FALSE |
5 | GTEx | Artery Aorta | CRLF3 | 0.12 | 0.03 | enet | 33 | 0.06 | 3.8e-04 | 1.00 | -7.2 | 4.3e-13 | 0.53 | 0.25 | 0.70 | TRUE |
6 | GTEx | Artery Tibial | RP11-848P1.7 | 0.54 | 0.00 | lasso | 10 | 0.02 | 7.3e-03 | -6.67 | -11.0 | 6.1e-28 | 0.47 | 0.02 | 0.06 | TRUE |
7 | GTEx | Brain Cerebellar Hemisphere | CRLF3 | 0.38 | 0.35 | enet | 26 | 0.35 | 6.0e-10 | 2.43 | -5.7 | 1.1e-08 | 0.32 | 0.97 | 0.01 | FALSE |
8 | GTEx | Brain Cerebellum | CRLF3 | 0.52 | 0.12 | lasso | 27 | 0.20 | 1.3e-06 | -10.39 | -9.1 | 1.2e-19 | 0.56 | 0.09 | 0.74 | FALSE |
9 | GTEx | Breast Mammary Tissue | CRLF3 | 0.10 | 0.10 | lasso | 3 | 0.05 | 9.6e-04 | 2.95 | -5.1 | 2.8e-07 | 0.31 | 0.09 | 0.62 | FALSE |
10 | GTEx | Cells EBV-transformed lymphocytes | EVI2A | 0.13 | 0.03 | lasso | 4 | 0.01 | 1.5e-01 | 7.29 | -7.8 | 9.2e-15 | 0.17 | 0.16 | 0.04 | FALSE |
11 | GTEx | Cells Transformed fibroblasts | OMG | 0.06 | 0.02 | lasso | 2 | 0.01 | 2.5e-02 | 7.31 | 7.4 | 1.8e-13 | -0.22 | 0.14 | 0.07 | FALSE |
12 | GTEx | Esophagus Muscularis | BLMH | 0.15 | 0.02 | lasso | 8 | 0.01 | 1.0e-01 | -3.28 | 5.3 | 8.9e-08 | -0.13 | 0.04 | 0.46 | TRUE |
13 | GTEx | Esophagus Muscularis | CRLF3 | 0.17 | 0.12 | lasso | 6 | 0.18 | 5.1e-11 | 2.44 | -7.2 | 7.1e-13 | 0.46 | 0.94 | 0.05 | FALSE |
14 | GTEx | Muscle Skeletal | TP53I13 | 0.08 | 0.02 | lasso | 4 | 0.02 | 2.2e-03 | -4.83 | 5.8 | 8.2e-09 | -0.08 | 0.07 | 0.32 | TRUE |
15 | GTEx | Nerve Tibial | CRLF3 | 0.38 | 0.16 | lasso | 14 | 0.19 | 3.0e-13 | 2.56 | -6.0 | 1.9e-09 | 0.38 | 1.00 | 0.00 | FALSE |
16 | GTEx | Ovary | CRLF3 | 0.21 | 0.14 | lasso | 4 | 0.11 | 1.0e-03 | 2.44 | -6.1 | 1.3e-09 | 0.40 | 0.06 | 0.58 | FALSE |
17 | GTEx | Pituitary | SUZ12P | 0.29 | 0.23 | lasso | 9 | 0.32 | 6.0e-09 | 2.43 | -5.9 | 3.0e-09 | 0.40 | 0.86 | 0.07 | TRUE |
18 | GTEx | Spleen | EVI2A | 0.22 | 0.12 | lasso | 4 | 0.07 | 8.3e-03 | 7.50 | -7.3 | 2.0e-13 | 0.17 | 0.11 | 0.05 | FALSE |
19 | GTEx | Spleen | OMG | 0.41 | 0.10 | enet | 26 | 0.08 | 4.5e-03 | 7.31 | 6.7 | 3.0e-11 | -0.23 | 0.64 | 0.03 | FALSE |
20 | GTEx | Testis | CRLF3 | 0.26 | 0.19 | enet | 23 | 0.17 | 3.8e-08 | 2.60 | -5.4 | 7.5e-08 | 0.38 | 0.99 | 0.00 | FALSE |
21 | GTEx | Thyroid | CRLF3 | 0.10 | 0.04 | enet | 35 | 0.08 | 1.1e-06 | 2.56 | -5.7 | 1.5e-08 | 0.38 | 0.91 | 0.05 | FALSE |
22 | GTEx | Whole Blood | EVI2A | 0.07 | 0.04 | lasso | 4 | 0.04 | 2.6e-04 | 7.34 | -7.5 | 4.6e-14 | 0.14 | 0.89 | 0.00 | FALSE |
23 | METSIM | Adipose | CTD-2349P21.5 | 0.02 | 0.00 | bslmm | 252 | 0.01 | 3.0e-03 | -8.70 | -6.6 | 5.0e-11 | 0.33 | 0.04 | 0.31 | FALSE |
24 | METSIM | Adipose | NF1 | 0.04 | 0.00 | blup | 396 | 0.01 | 5.5e-03 | 7.91 | 7.8 | 7.9e-15 | -0.30 | 0.80 | 0.02 | FALSE |
25 | METSIM | Adipose | TEFM | 0.08 | 0.06 | blup | 246 | 0.06 | 8.8e-10 | -12.09 | -7.5 | 6.6e-14 | 0.57 | 0.00 | 1.00 | TRUE |
26 | YFS | Blood | EVI2A | 0.03 | 0.05 | lasso | 4 | 0.04 | 1.0e-13 | 7.50 | -7.5 | 5.8e-14 | 0.10 | 1.00 | 0.00 | FALSE |
27 | YFS | Blood | EVI2B | 0.01 | 0.00 | blup | 339 | 0.00 | 6.4e-02 | -0.47 | 6.6 | 4.4e-11 | -0.26 | 0.07 | 0.02 | FALSE |
28 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | EVI2A | 0.03 | 0.03 | blup | 37 | 0.03 | 2.3e-03 | 7.39 | -7.3 | 2.5e-13 | 0.10 | 0.02 | 0.76 | FALSE |
29 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | OMG | 0.02 | 0.02 | blup | 31 | 0.02 | 3.2e-03 | 7.38 | -7.8 | 8.7e-15 | 0.15 | 0.02 | 0.82 | FALSE |
30 | The Cancer Genome Atlas | Breast Invasive Carcinoma | EVI2A | 0.03 | 0.03 | blup | 38 | 0.03 | 6.9e-07 | 7.30 | -7.6 | 3.1e-14 | 0.12 | 0.03 | 0.97 | FALSE |
31 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GOSR1 | 0.02 | 0.01 | enet | 4 | 0.01 | 1.7e-02 | -6.73 | 6.8 | 7.5e-12 | -0.27 | 0.01 | 0.83 | FALSE |
32 | The Cancer Genome Atlas | Breast Invasive Carcinoma | OMG | 0.03 | 0.04 | lasso | 1 | 0.04 | 1.1e-08 | 7.38 | -7.4 | 1.5e-13 | 0.23 | 0.02 | 0.98 | FALSE |
33 | The Cancer Genome Atlas | Colon Adenocarcinoma | LRRC37B2 | 0.09 | 0.00 | enet | 11 | 0.03 | 7.3e-03 | 3.46 | -6.3 | 3.5e-10 | 0.47 | 0.01 | 0.26 | TRUE |
34 | The Cancer Genome Atlas | Esophageal Carcinoma | OMG | 0.09 | 0.09 | blup | 31 | 0.11 | 2.0e-04 | 7.46 | -7.8 | 5.9e-15 | 0.18 | 0.02 | 0.91 | FALSE |
35 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | EVI2A | 0.04 | 0.00 | blup | 37 | 0.01 | 1.1e-02 | 7.33 | -5.8 | 8.2e-09 | 0.00 | 0.01 | 0.47 | FALSE |
36 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | OMG | 0.02 | 0.02 | blup | 31 | 0.03 | 6.9e-04 | 7.43 | -7.8 | 7.6e-15 | 0.17 | 0.02 | 0.89 | FALSE |
37 | The Cancer Genome Atlas | Brain Lower Grade Glioma | EVI2A | 0.03 | 0.03 | blup | 38 | 0.04 | 3.0e-05 | 7.33 | -7.8 | 7.7e-15 | 0.16 | 0.04 | 0.96 | FALSE |
38 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | NF1 | 0.04 | 0.03 | blup | 111 | 0.03 | 1.3e-02 | 7.39 | 7.6 | 2.3e-14 | -0.19 | 0.06 | 0.60 | FALSE |
39 | The Cancer Genome Atlas | Lung Adenocarcinoma | EVI2A | 0.04 | 0.06 | blup | 38 | 0.06 | 3.0e-07 | 7.28 | -7.7 | 1.4e-14 | 0.15 | 0.06 | 0.94 | FALSE |
40 | The Cancer Genome Atlas | Lung Adenocarcinoma | OMG | 0.05 | 0.03 | lasso | 5 | 0.04 | 3.6e-05 | 7.26 | -6.7 | 1.8e-11 | 0.10 | 0.03 | 0.92 | FALSE |
41 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | EVI2A | 0.03 | 0.03 | lasso | 1 | 0.02 | 2.4e-03 | 7.20 | -7.2 | 6.2e-13 | 0.10 | 0.02 | 0.64 | FALSE |
42 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | GOSR1 | 0.15 | 0.00 | blup | 56 | 0.04 | 1.1e-03 | -3.33 | 6.0 | 1.4e-09 | -0.35 | 0.04 | 0.19 | FALSE |
43 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | OMG | 0.05 | 0.03 | blup | 32 | 0.03 | 5.6e-03 | 7.31 | -7.0 | 2.0e-12 | 0.25 | 0.02 | 0.71 | FALSE |
44 | The Cancer Genome Atlas | Prostate Adenocarcinoma | EVI2A | 0.08 | 0.12 | lasso | 3 | 0.12 | 1.3e-12 | 7.91 | -7.8 | 6.4e-15 | 0.12 | 0.02 | 0.98 | FALSE |
45 | The Cancer Genome Atlas | Stomach Adenocarcinoma | EVI2A | 0.05 | 0.03 | enet | 7 | 0.04 | 4.8e-04 | 3.60 | -6.0 | 1.5e-09 | 0.13 | 0.04 | 0.64 | FALSE |
46 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SUZ12P | 0.05 | 0.05 | blup | 29 | 0.04 | 5.1e-04 | 2.95 | -5.5 | 4.7e-08 | 0.32 | 0.16 | 0.16 | TRUE |
47 | The Cancer Genome Atlas | Thyroid Carcinoma | OMG | 0.02 | 0.01 | blup | 32 | 0.02 | 4.8e-03 | 7.31 | -7.8 | 7.6e-15 | 0.18 | 0.02 | 0.86 | FALSE |