[Hub]/) : Traits : Arm fat-free mass (left) : ← →

chr17:6,444,676-8,765,412

Best TWAS P=9.51e-14 · Best GWAS P=4.3e-19 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
9	GTEx	Esophagus Mucosa	CHRNB1	0.19	0.11	lasso	2	0.13	7.3e-09	7.38	7.5	9.5e-14	0.29	1.00	0.00	TRUE
31	The Cancer Genome Atlas	Brain Lower Grade Glioma	CHRNB1	0.05	0.04	blup	57	0.04	6.1e-05	6.24	7.1	1.5e-12	0.23	0.00	1.00	TRUE
7	GTEx	Cells Transformed fibroblasts	CHRNB1	0.28	0.11	enet	25	0.18	2.9e-13	7.38	6.5	5.8e-11	0.46	0.97	0.03	TRUE
23	The Cancer Genome Atlas	Breast Invasive Carcinoma	CHRNB1	0.06	0.06	enet	10	0.06	1.0e-11	7.33	6.5	1.0e-10	0.32	0.00	1.00	TRUE
2	CommonMind	Brain Pre-frontal Cortex	EIF5A	0.20	0.12	bslmm	446	0.10	1.2e-12	-4.17	-6.4	1.8e-10	-0.05	1.00	0.00	TRUE
11	GTEx	Esophagus Muscularis	ZBTB4	0.13	0.06	lasso	2	0.05	6.3e-04	5.91	5.8	8.6e-09	0.26	0.28	0.25	TRUE
21	YFS	Blood	PHF23	0.03	0.01	bslmm	450	0.02	5.9e-08	6.72	-5.6	1.7e-08	0.05	0.87	0.01	TRUE
22	YFS	Blood	TMEM107	0.17	0.17	lasso	5	0.19	2.0e-61	-5.21	-5.5	4.2e-08	-0.08	0.62	0.38	TRUE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	TNFSF12-TNFSF13	0.07	0.01	enet	17	0.03	4.4e-04	-4.87	-5.5	4.4e-08	-0.08	0.03	0.08	TRUE
30	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CHRNB1	0.06	0.07	lasso	6	0.07	1.8e-08	4.25	5.5	4.8e-08	0.28	0.53	0.47	TRUE
18	METSIM	Adipose	NEURL4	0.06	0.00	blup	454	0.01	8.2e-03	-0.93	-5.4	6.2e-08	-0.02	0.11	0.02	TRUE
8	GTEx	Esophagus Mucosa	SOX15	0.16	0.03	enet	9	0.07	2.3e-05	8.93	-5.2	1.6e-07	-0.74	0.00	0.98	TRUE
13	GTEx	Skin Not Sun Exposed Suprapubic	CHRNB1	0.17	0.15	lasso	3	0.16	7.4e-09	7.38	7.3	2.9e-13	0.29	1.00	0.00	FALSE
4	GTEx	Adipose Visceral Omentum	CHRNB1	0.29	0.14	lasso	5	0.14	1.0e-07	7.38	7.3	3.4e-13	0.27	0.96	0.00	FALSE
36	The Cancer Genome Atlas	Prostate Adenocarcinoma	TNFSF12-TNFSF13	0.03	0.00	lasso	4	0.01	2.9e-02	-4.87	-7.2	6.5e-13	-0.45	0.01	0.66	FALSE
40	The Cancer Genome Atlas	Thyroid Carcinoma	SHBG	0.04	0.00	blup	59	0.02	4.4e-03	-4.04	-7.1	9.9e-13	-0.46	0.04	0.08	FALSE
20	YFS	Blood	CHRNB1	0.04	0.02	lasso	5	0.04	8.5e-12	7.33	7.0	2.8e-12	0.31	1.00	0.00	FALSE
37	The Cancer Genome Atlas	Stomach Adenocarcinoma	CHRNB1	0.06	0.00	blup	57	0.03	4.5e-03	3.60	6.9	5.8e-12	0.34	0.00	0.76	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	CHRNB1	0.11	0.08	lasso	6	0.08	7.8e-11	7.38	6.8	1.4e-11	0.30	1.00	0.00	FALSE
24	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	CHRNB1	0.07	0.04	blup	57	0.05	1.6e-03	7.38	6.7	2.4e-11	0.34	0.00	0.88	FALSE
39	The Cancer Genome Atlas	Thyroid Carcinoma	SENP3	0.07	0.04	enet	9	0.03	2.7e-04	4.23	6.7	2.7e-11	0.20	0.11	0.75	FALSE
1	CommonMind	Brain Pre-frontal Cortex	CHRNB1	0.09	0.06	lasso	2	0.08	9.8e-10	7.38	6.5	9.0e-11	0.16	0.99	0.00	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	CHRNB1	0.18	0.09	enet	10	0.10	4.9e-11	7.38	6.5	1.1e-10	0.30	0.00	1.00	FALSE
16	GTEx	Whole Blood	TNFSF12	0.09	0.03	enet	24	0.04	1.9e-04	-4.91	-6.4	1.7e-10	-0.43	0.42	0.44	FALSE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	CHRNB1	0.03	0.02	blup	57	0.02	7.8e-04	7.33	6.3	3.7e-10	0.36	0.00	0.99	FALSE
27	The Cancer Genome Atlas	Glioblastoma Multiforme	AMAC1L3	0.14	0.12	lasso	3	0.12	1.8e-04	6.06	-6.2	4.1e-10	-0.25	0.01	0.86	FALSE
5	GTEx	Artery Tibial	TNFSF12	0.11	0.06	lasso	2	0.05	1.2e-04	6.25	6.2	4.2e-10	0.52	0.26	0.66	FALSE
38	The Cancer Genome Atlas	Thyroid Carcinoma	CHRNB1	0.09	0.02	blup	57	0.05	2.6e-05	-3.45	6.1	8.7e-10	0.23	0.11	0.76	FALSE
15	GTEx	Stomach	CHRNB1	0.28	0.19	lasso	4	0.23	2.0e-11	7.38	6.1	1.4e-09	0.15	0.97	0.00	FALSE
6	GTEx	Breast Mammary Tissue (Male)	CHRNB1	0.28	-0.01	lasso	6	0.02	9.6e-02	7.38	6.0	2.0e-09	0.20	0.07	0.07	FALSE
3	CommonMind	Brain Pre-frontal Cortex	POLR2A	0.08	0.07	lasso	4	0.07	1.9e-08	5.78	6.0	2.4e-09	0.18	1.00	0.00	FALSE
12	GTEx	Muscle Skeletal	EIF5A	0.14	0.06	enet	35	0.05	4.2e-06	-4.12	-6.0	2.5e-09	-0.02	0.96	0.00	FALSE
14	GTEx	Skin Sun Exposed Lower leg	CHRNB1	0.19	0.12	enet	13	0.12	3.0e-10	5.98	6.0	2.7e-09	0.22	1.00	0.00	FALSE
10	GTEx	Esophagus Mucosa	ZBTB4	0.12	0.10	lasso	2	0.08	8.0e-06	5.92	5.9	3.9e-09	0.26	0.96	0.00	FALSE
26	The Cancer Genome Atlas	Esophageal Carcinoma	EIF5A	0.16	0.00	blup	50	0.03	5.0e-02	-4.40	-5.4	7.5e-08	0.08	0.02	0.05	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ALOXE3	0.04	0.00	blup	77	0.01	3.4e-02	-5.13	-5.2	1.5e-07	0.00	0.00	0.57	FALSE
28	The Cancer Genome Atlas	Glioblastoma Multiforme	EIF5A	0.26	0.10	blup	51	0.05	9.7e-03	4.53	-5.2	2.0e-07	0.14	0.04	0.06	FALSE
25	The Cancer Genome Atlas	Colon Adenocarcinoma	TNFSF12-TNFSF13	0.07	0.05	lasso	3	0.02	1.9e-02	-5.02	-5.1	2.9e-07	-0.22	0.08	0.04	FALSE
17	METSIM	Adipose	CNTROB	0.06	0.02	blup	497	0.03	1.3e-05	1.96	-5.1	3.0e-07	-0.08	0.89	0.00	FALSE
34	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EFNB3	0.07	0.04	blup	34	0.04	4.0e-05	-5.05	5.1	3.0e-07	0.34	0.16	0.07	FALSE