Best TWAS P=2.67e-36 · Best GWAS P=4.99e-24 conditioned to NaN
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | CCDC92 | 0.09 | 0.01 | bslmm | 438 | 0.03 | 3.1e-04 | 8.8 | -5.2 | 1.5e-07 | -0.67 | 0.11 | 0.86 | TRUE |
2 | CommonMind | Brain Pre-frontal Cortex | HIP1R | 0.06 | 0.02 | lasso | 6 | 0.04 | 1.9e-05 | -4.7 | -5.2 | 2.1e-07 | 0.01 | 0.18 | 0.02 | FALSE |
3 | GTEx | Adipose Subcutaneous | CCDC92 | 0.23 | 0.04 | enet | 27 | 0.16 | 6.9e-13 | -7.6 | 11.6 | 3.9e-31 | 0.48 | 0.17 | 0.83 | FALSE |
4 | GTEx | Adipose Subcutaneous | RP11-380L11.3 | 0.09 | 0.03 | lasso | 3 | 0.03 | 1.4e-03 | 9.7 | 12.3 | 8.7e-35 | 0.87 | 0.02 | 0.97 | FALSE |
5 | GTEx | Adipose Subcutaneous | RP11-380L11.4 | 0.08 | 0.06 | lasso | 4 | 0.04 | 1.9e-04 | 6.8 | 6.3 | 2.7e-10 | 0.58 | 0.14 | 0.84 | FALSE |
6 | GTEx | Adipose Visceral Omentum | CCDC92 | 0.19 | 0.02 | lasso | 8 | 0.09 | 3.3e-05 | 9.8 | 12.5 | 7.1e-36 | 0.63 | 0.05 | 0.94 | FALSE |
7 | GTEx | Adipose Visceral Omentum | RP11-380L11.3 | 0.15 | 0.03 | lasso | 5 | 0.01 | 1.4e-01 | 8.3 | 12.6 | 2.7e-36 | 0.65 | 0.04 | 0.74 | TRUE |
8 | GTEx | Artery Aorta | P2RX4 | 0.20 | 0.03 | enet | 28 | 0.05 | 1.6e-03 | -3.6 | -5.2 | 2.4e-07 | 0.04 | 0.12 | 0.60 | TRUE |
9 | GTEx | Artery Tibial | SIRT4 | 0.30 | 0.14 | lasso | 8 | 0.14 | 4.3e-11 | -6.0 | -6.0 | 1.8e-09 | -0.04 | 0.01 | 0.99 | FALSE |
10 | GTEx | Artery Tibial | RP11-380L11.4 | 0.14 | 0.12 | lasso | 4 | 0.12 | 2.2e-09 | 9.7 | 9.7 | 3.1e-22 | 0.95 | 0.05 | 0.95 | TRUE |
11 | GTEx | Artery Tibial | RP11-347I19.8 | 0.16 | 0.09 | enet | 26 | 0.10 | 1.7e-08 | 3.9 | -5.4 | 6.1e-08 | 0.09 | 0.99 | 0.00 | FALSE |
12 | GTEx | Brain Cerebellar Hemisphere | WDR66 | 0.28 | 0.05 | lasso | 8 | 0.04 | 3.6e-02 | -4.5 | -5.7 | 1.2e-08 | -0.03 | 0.08 | 0.19 | FALSE |
13 | GTEx | Brain Cerebellum | SIRT4 | 0.48 | -0.01 | enet | 32 | 0.24 | 9.2e-08 | -6.0 | -5.8 | 9.1e-09 | -0.10 | 0.02 | 0.88 | FALSE |
14 | GTEx | Brain Putamen basal ganglia | WDR66 | 0.25 | 0.01 | enet | 16 | -0.01 | 5.6e-01 | 5.9 | -6.4 | 1.8e-10 | 0.01 | 0.06 | 0.23 | FALSE |
15 | GTEx | Breast Mammary Tissue | SIRT4 | 0.19 | 0.16 | lasso | 6 | 0.16 | 1.4e-08 | -6.0 | -5.8 | 5.1e-09 | -0.03 | 0.01 | 0.99 | FALSE |
16 | GTEx | Breast Mammary Tissue (Male) | CCDC92 | 0.06 | -0.01 | lasso | 3 | 0.00 | 4.3e-01 | 8.8 | 9.2 | 3.9e-20 | 0.85 | 0.04 | 0.14 | FALSE |
17 | GTEx | Breast Mammary Tissue (Female) | KDM2B | 0.13 | 0.00 | lasso | 3 | 0.01 | 1.2e-01 | -4.3 | 5.8 | 6.4e-09 | 0.10 | 0.04 | 0.30 | TRUE |
18 | GTEx | Breast Mammary Tissue (Female) | SIRT4 | 0.03 | 0.03 | lasso | 1 | 0.05 | 1.0e-02 | -5.7 | -5.7 | 1.3e-08 | -0.05 | 0.02 | 0.63 | FALSE |
19 | GTEx | Breast Mammary Tissue (Female) | CCDC92 | 0.05 | -0.01 | enet | 2 | -0.01 | 6.2e-01 | 8.8 | 8.8 | 1.9e-18 | 0.89 | 0.04 | 0.24 | TRUE |
20 | GTEx | Breast Mammary Tissue (Female) | C12orf65 | 0.06 | 0.00 | enet | 13 | -0.01 | 6.5e-01 | -3.7 | -5.5 | 4.5e-08 | -0.08 | 0.04 | 0.28 | FALSE |
21 | GTEx | Cells Transformed fibroblasts | BCL7A | 0.06 | 0.01 | lasso | 4 | 0.01 | 3.1e-02 | 5.4 | -8.4 | 2.9e-17 | -0.04 | 0.09 | 0.05 | TRUE |
22 | GTEx | Cells Transformed fibroblasts | CCDC92 | 0.09 | 0.00 | enet | 28 | 0.01 | 3.8e-02 | 7.6 | 6.3 | 3.0e-10 | 0.40 | 0.07 | 0.24 | FALSE |
23 | GTEx | Colon Sigmoid | RP11-380L11.4 | 0.21 | 0.12 | lasso | 3 | 0.08 | 1.1e-03 | 9.7 | 9.8 | 6.9e-23 | 0.91 | 0.05 | 0.87 | FALSE |
24 | GTEx | Colon Transverse | MLXIP | 0.20 | 0.18 | enet | 23 | 0.14 | 5.8e-07 | 5.9 | 5.8 | 7.3e-09 | -0.08 | 1.00 | 0.00 | FALSE |
25 | GTEx | Colon Transverse | SNRNP35 | 0.18 | 0.02 | lasso | 8 | 0.04 | 6.5e-03 | -3.3 | 6.8 | 1.2e-11 | 0.15 | 0.08 | 0.07 | TRUE |
26 | GTEx | Esophagus Mucosa | KDM2B | 0.11 | 0.04 | enet | 22 | 0.10 | 4.1e-07 | 3.5 | 7.0 | 2.2e-12 | 0.04 | 0.91 | 0.01 | FALSE |
27 | GTEx | Esophagus Mucosa | CCDC92 | 0.11 | 0.02 | lasso | 4 | 0.02 | 1.9e-02 | 8.9 | 9.1 | 1.0e-19 | 0.89 | 0.09 | 0.81 | FALSE |
28 | GTEx | Esophagus Mucosa | HIP1R | 0.21 | 0.05 | lasso | 5 | 0.07 | 1.5e-05 | 4.5 | 7.3 | 3.4e-13 | -0.05 | 0.47 | 0.26 | TRUE |
29 | GTEx | Esophagus Muscularis | RP11-380L11.4 | 0.27 | 0.29 | lasso | 8 | 0.27 | 1.0e-16 | 9.8 | 9.8 | 1.7e-22 | 0.94 | 0.05 | 0.95 | FALSE |
30 | GTEx | Heart Atrial Appendage | CCDC92 | 0.12 | 0.11 | enet | 9 | 0.11 | 1.1e-05 | 7.1 | 9.3 | 2.0e-20 | 0.79 | 0.06 | 0.92 | FALSE |
31 | GTEx | Heart Atrial Appendage | RP11-380L11.4 | 0.18 | 0.11 | lasso | 7 | 0.12 | 6.5e-06 | 9.8 | 10.5 | 1.3e-25 | 0.92 | 0.03 | 0.96 | FALSE |
32 | GTEx | Heart Left Ventricle | CCDC92 | 0.26 | 0.19 | lasso | 4 | 0.21 | 1.9e-11 | 8.9 | 10.7 | 1.5e-26 | 0.87 | 0.12 | 0.88 | FALSE |
33 | GTEx | Lung | SIRT4 | 0.11 | 0.06 | lasso | 8 | 0.01 | 3.8e-02 | -6.0 | -5.9 | 2.8e-09 | -0.03 | 0.01 | 0.99 | FALSE |
34 | GTEx | Lung | CCDC92 | 0.14 | 0.00 | enet | 10 | 0.01 | 1.1e-01 | 9.0 | 9.2 | 3.7e-20 | 0.18 | 0.18 | 0.11 | TRUE |
35 | GTEx | Lung | RP11-380L11.4 | 0.07 | 0.07 | lasso | 3 | 0.07 | 8.2e-06 | 9.8 | 9.7 | 3.1e-22 | 0.94 | 0.04 | 0.96 | FALSE |
36 | GTEx | Muscle Skeletal | RSRC2 | 0.06 | 0.03 | enet | 7 | 0.04 | 9.6e-05 | -3.0 | -5.9 | 3.9e-09 | -0.03 | 0.25 | 0.48 | FALSE |
37 | GTEx | Muscle Skeletal | RP11-380L11.4 | 0.14 | 0.03 | lasso | 8 | 0.03 | 4.0e-04 | 9.7 | 8.3 | 9.9e-17 | 0.90 | 0.02 | 0.97 | FALSE |
38 | GTEx | Muscle Skeletal | RP11-347I19.8 | 0.08 | 0.06 | lasso | 4 | 0.06 | 2.4e-06 | 3.8 | -5.2 | 2.2e-07 | 0.07 | 0.95 | 0.01 | FALSE |
39 | GTEx | Nerve Tibial | SIRT4 | 0.23 | 0.21 | lasso | 5 | 0.20 | 4.6e-14 | -5.6 | -6.0 | 1.9e-09 | -0.03 | 0.01 | 0.99 | FALSE |
40 | GTEx | Nerve Tibial | CCDC92 | 0.16 | 0.01 | enet | 6 | 0.04 | 6.7e-04 | 8.6 | 10.1 | 6.1e-24 | 0.68 | 0.07 | 0.64 | FALSE |
41 | GTEx | Nerve Tibial | KNTC1 | 0.12 | 0.05 | lasso | 5 | 0.05 | 1.9e-04 | -5.7 | -6.3 | 2.6e-10 | 0.02 | 0.53 | 0.03 | FALSE |
42 | GTEx | Pancreas | SIRT4 | 0.40 | 0.37 | lasso | 7 | 0.37 | 1.8e-16 | -5.7 | -6.0 | 1.6e-09 | -0.03 | 0.01 | 0.99 | TRUE |
43 | GTEx | Pancreas | RP11-347I19.8 | 0.12 | 0.00 | enet | 13 | 0.00 | 2.9e-01 | 3.9 | -5.4 | 7.1e-08 | 0.05 | 0.09 | 0.11 | FALSE |
44 | GTEx | Prostate | CCDC92 | 0.31 | 0.10 | enet | 42 | 0.11 | 9.0e-04 | 8.8 | 7.9 | 2.9e-15 | 0.48 | 0.06 | 0.70 | FALSE |
45 | GTEx | Skin Sun Exposed Lower leg | CCDC92 | 0.11 | 0.00 | enet | 15 | 0.01 | 1.0e-01 | 7.6 | 6.9 | 5.7e-12 | 0.50 | 0.07 | 0.44 | FALSE |
46 | GTEx | Skin Sun Exposed Lower leg | AC084018.1 | 0.29 | 0.15 | enet | 22 | 0.21 | 3.5e-17 | 3.9 | -5.2 | 2.5e-07 | 0.10 | 1.00 | 0.00 | FALSE |
47 | GTEx | Skin Sun Exposed Lower leg | RP11-380L11.4 | 0.04 | 0.02 | enet | 15 | 0.02 | 1.9e-02 | 9.9 | 8.9 | 6.5e-19 | 0.83 | 0.02 | 0.96 | FALSE |
48 | GTEx | Stomach | SIRT4 | 0.14 | 0.14 | enet | 8 | 0.09 | 3.1e-05 | -5.7 | -5.6 | 2.8e-08 | -0.04 | 0.01 | 0.99 | FALSE |
49 | GTEx | Stomach | RP11-347I19.8 | 0.22 | 0.09 | lasso | 7 | 0.11 | 4.2e-06 | 4.1 | -5.5 | 5.1e-08 | 0.08 | 0.95 | 0.01 | FALSE |
50 | GTEx | Thyroid | CCDC92 | 0.06 | 0.03 | lasso | 3 | 0.02 | 1.1e-02 | 9.7 | 10.9 | 1.3e-27 | 0.89 | 0.04 | 0.93 | FALSE |
51 | GTEx | Thyroid | ZNF664 | 0.13 | 0.06 | lasso | 11 | 0.08 | 6.7e-07 | 8.8 | -9.8 | 1.1e-22 | -0.87 | 0.07 | 0.93 | FALSE |
52 | METSIM | Adipose | ABCB9 | 0.04 | 0.03 | enet | 19 | 0.03 | 7.7e-05 | -4.7 | -7.0 | 2.7e-12 | 0.12 | 0.08 | 0.65 | FALSE |
53 | METSIM | Adipose | CCDC92 | 0.10 | 0.01 | bslmm | 435 | 0.06 | 5.5e-10 | -4.9 | 11.3 | 1.7e-29 | 0.62 | 0.17 | 0.83 | FALSE |
54 | METSIM | Adipose | DNAH10 | 0.03 | 0.00 | bslmm | 475 | 0.01 | 3.2e-03 | 10.1 | 9.1 | 6.3e-20 | 0.66 | 0.01 | 0.93 | FALSE |
55 | METSIM | Adipose | MORN3 | 0.06 | 0.02 | lasso | 10 | 0.04 | 8.7e-07 | 6.2 | 7.2 | 9.0e-13 | 0.01 | 0.02 | 0.98 | FALSE |
56 | METSIM | Adipose | RP11-214K3.24 | 0.05 | 0.03 | bslmm | 444 | 0.02 | 2.7e-04 | 8.9 | 10.5 | 7.0e-26 | 0.73 | 0.05 | 0.91 | FALSE |
57 | METSIM | Adipose | SIRT4 | 0.06 | 0.04 | enet | 20 | 0.03 | 6.6e-06 | -6.0 | -5.2 | 1.9e-07 | -0.05 | 0.01 | 0.99 | FALSE |
58 | NTR | Blood | MORN3 | 0.02 | 0.01 | lasso | 4 | 0.01 | 1.2e-05 | 5.7 | 5.6 | 2.6e-08 | 0.02 | 0.02 | 0.98 | FALSE |
59 | NTR | Blood | ZNF664 | 0.02 | 0.00 | bslmm | 447 | 0.01 | 6.3e-04 | -5.2 | -6.5 | 8.1e-11 | -0.57 | 0.02 | 0.86 | FALSE |
60 | YFS | Blood | MORN3 | 0.12 | 0.13 | lasso | 7 | 0.15 | 4.9e-48 | 6.2 | 5.9 | 3.2e-09 | 0.01 | 0.02 | 0.98 | FALSE |
61 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DNAH10 | 0.11 | 0.03 | blup | 99 | 0.05 | 8.2e-11 | 7.0 | 9.7 | 4.0e-22 | 0.71 | 0.05 | 0.95 | FALSE |
62 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SIRT4 | 0.06 | 0.06 | lasso | 4 | 0.05 | 2.8e-11 | -6.0 | -5.9 | 3.3e-09 | -0.04 | 0.00 | 1.00 | FALSE |
63 | The Cancer Genome Atlas | Colon Adenocarcinoma | LOC338799 | 0.06 | 0.03 | blup | 31 | 0.05 | 5.2e-04 | 4.3 | -5.3 | 9.4e-08 | 0.09 | 0.01 | 0.21 | FALSE |
64 | The Cancer Genome Atlas | Colon Adenocarcinoma | MLXIP | 0.06 | 0.04 | lasso | 7 | 0.02 | 2.7e-02 | 5.8 | 5.9 | 3.4e-09 | -0.07 | 0.02 | 0.92 | FALSE |
65 | The Cancer Genome Atlas | Glioblastoma Multiforme | CCDC92 | 0.07 | 0.02 | blup | 52 | 0.04 | 1.8e-02 | 8.8 | 9.2 | 2.7e-20 | 0.93 | 0.02 | 0.73 | FALSE |
66 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CCDC92 | 0.06 | 0.04 | enet | 8 | 0.05 | 1.7e-06 | 9.0 | 6.3 | 3.2e-10 | 0.75 | 0.06 | 0.91 | FALSE |
67 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DNAH10 | 0.07 | 0.03 | lasso | 3 | 0.05 | 7.4e-06 | 9.8 | 9.4 | 7.6e-21 | 0.80 | 0.02 | 0.97 | FALSE |
68 | The Cancer Genome Atlas | Lung Adenocarcinoma | LOC338799 | 0.04 | 0.02 | blup | 29 | 0.04 | 3.5e-05 | 4.1 | -5.5 | 5.0e-08 | 0.07 | 0.02 | 0.49 | FALSE |
69 | The Cancer Genome Atlas | Rectum Adenocarcinoma | MLXIP | 0.18 | 0.14 | lasso | 4 | 0.13 | 5.1e-04 | 5.2 | 5.6 | 2.7e-08 | -0.08 | 0.02 | 0.88 | FALSE |
70 | The Cancer Genome Atlas | Soft Tissue Sarcoma | CCDC92 | 0.05 | 0.03 | blup | 52 | 0.03 | 5.8e-03 | 4.4 | 7.9 | 3.4e-15 | 0.91 | 0.04 | 0.63 | FALSE |
71 | The Cancer Genome Atlas | Stomach Adenocarcinoma | MLXIP | 0.06 | 0.02 | blup | 68 | 0.04 | 1.2e-03 | 5.9 | 7.3 | 2.1e-13 | -0.03 | 0.02 | 0.84 | TRUE |
72 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SIRT4 | 0.10 | 0.06 | blup | 37 | 0.08 | 1.3e-06 | -5.7 | -5.2 | 1.8e-07 | -0.04 | 0.01 | 0.99 | FALSE |
73 | The Cancer Genome Atlas | Thyroid Carcinoma | DNAH10 | 0.04 | 0.03 | lasso | 5 | 0.02 | 4.6e-03 | 8.6 | 9.3 | 1.9e-20 | 0.86 | 0.01 | 0.88 | FALSE |
74 | The Cancer Genome Atlas | Thyroid Carcinoma | VPS33A | 0.06 | 0.00 | enet | 8 | 0.03 | 9.6e-04 | 4.5 | -5.8 | 8.6e-09 | 0.02 | 0.07 | 0.92 | FALSE |
75 | The Cancer Genome Atlas | Thyroid Carcinoma | ZNF664 | 0.06 | 0.05 | enet | 9 | 0.05 | 2.8e-05 | 9.7 | -9.7 | 2.3e-22 | -0.92 | 0.03 | 0.97 | FALSE |