Hub : Genes

BCL7A

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.0650	0.0310	5.0e-03	0.008	NA	0.001	NA	0.014	7.0e-02	NA	2.5e-01	NA	3.1e-02
2	GTEx	Muscle Skeletal	0.1639	0.0441	4.4e-09	0.171	NA	0.148	NA	0.163	1.7e-16	NA	2.3e-14	NA	8.6e-16
3	GTEx	Testis	0.1960	0.0640	4.0e-04	0.101	NA	0.094	NA	0.098	3.0e-05	NA	5.9e-05	NA	4.2e-05
4	NTR	Blood	0.0144	0.0070	9.1e-03	0.002	0.003	0.001	0.004	0.002	7.3e-02	0.026	1.0e-01	0.016	4.5e-02

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.6	1.0	2.2	-1.5	0.8	1.0	-0.3
Bipolar Disorder or Schizophrenia	0.7	1.7	4.4	-2.1	0.9	0.7	1.0
Depressed Affect (Nagel 2018)	0.6	1.2	1.9	-1.4	-0.8	-0.6	1.3
Depression (Nagel 2018)	1.0	1.5	3.8	-1.3	-0.5	-0.7	2.0
Intelligence (Savage-Jansen 2018)	1.5	4.7	10.1	0.3	1.8	2.3	-3.2
Neuroticism (Nagel 2018)	0.6	1.4	2.6	-0.5	-1.6	-0.7	1.5
Schizophrenia (2018)	0.6	1.3	2.5	-1.5	0.5	0.1	1.6
Schizophrenia vs Biploar Disorder	1.5	2.0	4.2	1.1	-1.5	0.4	2.1
Worry (Nagel 2018)	0.2	0.3	0.7	-0.1	-0.8	0.2	0.8
Alzheimer’s Disease (in mother)	1.2	1.4	3.4	-1.1	0.8	-0.5	-1.9
Alzheimer’s Disease (in father)	0.4	0.5	1.0	-0.4	1.0	0.8	-0.0
Alzheimer’s Disease (including proxy)	1.3	1.8	4.0	-2.0	1.4	-0.0	-1.2
Crohns Disease (2017)	1.3	2.8	4.8	-1.4	2.2	1.7	-1.2
Irritable Bowel Disease (IBD)	1.0	2.3	5.0	-1.9	2.2	0.7	-0.6
Ulcerative Colitis (UC)	0.8	1.4	3.1	-1.8	1.6	-0.2	-0.1
Major Depression (MDD)	0.5	0.6	2.2	0.3	0.3	-0.4	1.5
Reaction Time	2.1	3.9	9.7	-0.4	3.1	0.6	-2.3
Verbal and Numeric Reasoning (VNR)	2.0	4.8	10.1	0.5	1.8	2.4	-3.2
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	1.1	1.4	2.6	-1.6	1.0	-0.1	-1.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.5	0.7	2.4	-0.5	0.2	0.2	1.6
Bipolar Disorder (2011)	0.3	0.3	0.7	-0.8	0.0	-0.2	0.8
Body Mass Index (BMI) (2010)	1.7	2.3	5.9	-2.4	0.9	-1.3	0.9
Coronary Artery Disease (CAD)	0.4	0.5	1.4	-0.3	0.0	0.7	1.2
Crohns Disease (2012)	1.4	2.2	4.4	-1.8	2.1	0.0	-1.1
Mean Putamen Volume	1.3	1.5	4.2	-2.1	-0.1	-1.0	0.8
Fasting Glucose	1.3	1.6	2.4	-1.6	0.9	-0.9	-1.4
HbA1C	0.3	0.4	1.2	-0.2	0.4	1.1	-0.2
HDL Cholesterol	2.5	4.1	5.9	-2.4	2.4	1.1	-1.9
LDL Cholesterol	0.7	1.1	1.6	1.0	-0.5	1.2	-1.2
Lupus	1.2	1.9	2.7	1.6	-1.4	-1.0	1.4
Neuroticism (2016)	0.4	0.5	1.0	1.0	-0.5	0.5	0.9
Primary Biliary Cirrhosis	0.5	0.8	1.2	0.1	-1.0	1.0	1.1
Rheumatoid Arthritis	0.7	1.0	1.3	-1.0	1.1	-1.1	-0.8
Schizophrenia (2014)	0.3	0.7	1.2	-0.9	0.1	0.9	1.1
Triglycerides	1.1	1.9	3.7	0.7	-1.5	-1.9	1.1
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.0	-0.5	0.7	-1.0	-0.5
Ulcerative Colitis	0.4	0.6	1.0	-1.0	1.0	-0.5	0.1
Blood Eosinophil Count	1.1	8.1	12.0	-3.0	3.5	1.2	-3.2
Blood Platelet Count	13.7	158.7	272.2	11.1	-15.1	-3.4	16.5
Blood Red Count	1.0	9.9	21.6	3.2	-4.6	-1.6	2.3
Blood White Count	0.1	0.4	0.8	-0.9	0.5	-0.8	0.1
Heel T-Score	1.6	12.5	22.8	4.8	-4.7	-2.2	0.6
BMI	3.2	18.5	58.1	-7.6	3.5	0.1	2.0
Height	0.7	14.2	29.9	-5.5	1.0	-1.1	5.0
Waist Hip Ratio (WHR)	0.1	0.4	1.0	0.5	-0.5	-1.0	0.2
Systolic Blood Pressure	1.9	9.7	17.7	4.2	-2.9	3.3	1.4
Smoking Status	0.9	2.1	6.6	-2.6	1.0	-0.9	0.4
Allergy or Eczema	0.6	1.5	3.6	-1.9	0.8	-0.3	1.3
Cardiovascular Disease	0.7	2.4	8.4	0.4	0.7	2.9	0.6
Hypothyroidism (self reported)	3.1	7.2	13.8	-3.6	3.7	-0.4	-1.4
Respiratory disease	0.1	0.3	0.9	-0.2	-0.3	-0.5	0.9
Type 2 Diabetes (T2D) (2018)	0.7	1.3	3.0	-1.4	0.0	-0.7	1.7
Lung FEV1/FVC ratio	0.5	2.5	6.8	1.5	-2.6	-0.9	-0.6
Lung FVC	0.2	0.8	1.7	0.2	-1.0	-0.7	-1.3
Neuroticism	0.3	0.7	1.1	-1.0	-0.7	-0.6	0.9
Chronotype (morning person)	0.4	0.8	2.2	1.5	-0.4	-0.8	-0.6
Hair Pigment	0.1	2.5	5.8	-2.4	0.7	-1.6	1.1
Tanning	0.1	0.7	1.3	-0.9	1.1	0.1	-0.6
Hand grip strength (left)	1.8	4.7	13.7	0.9	-3.7	-1.3	1.5
Number of treatments/medications taken	0.4	0.7	2.0	-0.9	-0.4	-0.1	1.4
Average weekly spirits intake	0.2	0.2	0.7	-0.8	-0.1	-0.4	0.1
Sensitivity / hurt feelings	0.1	0.1	0.5	0.7	-0.0	-0.2	0.0
Frequency of depressed mood in last 2 weeks	0.4	0.6	1.7	-0.5	-0.5	-0.5	1.3
Hearing difficulty/problems: Yes	1.0	1.5	2.8	-1.7	1.2	-1.3	0.2
Relative age of first facial hair	1.1	2.2	3.4	-1.3	1.8	-0.4	-1.9
Other serious medical condition/disability diagnosed by doctor	2.9	3.7	7.9	-2.8	2.6	-0.4	-0.2
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.9	-1.7	-0.2	-0.7	0.5
Ever had hysterectomy (womb removed)	0.7	0.7	2.9	-0.2	-0.1	-1.7	0.2
Systolic blood pressure, automated reading	0.9	2.5	3.6	1.0	-1.9	1.3	1.9
Eye problems/disorders: Diabetes related eye disease	1.0	1.1	1.5	0.8	-1.2	1.2	1.0
Angina	0.6	0.7	2.4	0.5	0.3	1.5	0.4
Medication for hormone replacement therapy	1.0	1.1	2.8	-1.7	-0.7	-1.0	0.1
Vitamin and mineral supplements	0.6	0.8	1.8	0.7	-1.3	-0.5	0.7
Supplements: Zinc	1.5	1.6	2.7	-1.6	1.3	-1.4	0.3
Medication: Co-codamol	1.0	1.1	2.2	-1.5	0.5	1.4	-0.4
Medication: Metformin	2.1	3.0	6.4	-1.1	-0.2	-2.1	2.5
Diabetes (father)	0.8	1.0	1.4	-1.0	1.0	0.8	-1.2
Diabetes (mother)	0.2	0.3	0.6	-0.4	-0.8	-0.5	-0.3
Severe depression (siblings)	2.1	2.3	5.7	-2.4	1.6	-0.1	-1.0
Pack years adult smoking proportion	1.3	2.1	4.0	-1.1	-1.1	-2.0	1.3
Impedance of leg (right)	0.6	3.1	8.3	-0.3	1.9	0.6	-2.9
Leg fat-free mass (left)	1.6	8.7	19.6	-4.4	0.1	-0.8	3.8
Trunk fat percentage	5.5	22.0	71.4	-8.4	4.0	0.4	0.7
Hand grip strength (right)	1.1	3.0	10.2	0.1	-3.2	-0.7	1.2
Townsend deprivation index at recruitment	0.8	1.1	3.6	-0.9	0.1	-1.9	0.0
Current tobacco smoking	0.5	0.8	1.9	-1.4	0.8	-0.7	-0.2
Average weekly fortified wine intake	0.2	0.3	0.9	-0.9	-0.0	-0.5	-0.1
Maternal smoking around birth	0.5	0.7	1.7	-1.3	0.6	0.7	-0.2
Fed-up feelings	1.1	1.9	3.7	0.1	-1.9	-0.8	1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	3.2	-1.2	-0.7	-0.0	1.8
Relative age voice broke	1.3	2.0	3.1	-1.8	1.4	-1.1	-1.3
Taking other prescription medications	0.5	0.8	2.0	-0.7	0.6	-0.5	1.4
Age when periods started (menarche)	1.0	2.4	8.2	0.1	1.2	-0.1	-2.9
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	2.0	-1.4	0.0	-0.6	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	5.1	1.2	-1.1	-2.2	1.8
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	1.4	-0.4	-0.4	-1.2	0.9
Qualifications: CSEs or equivalent	0.3	0.4	1.0	0.7	-1.0	0.5	0.1
Serious illness, injury or assault to yourself	0.6	0.7	1.6	-1.1	1.3	-0.1	0.2
High blood pressure	0.5	1.4	5.4	0.5	-0.1	2.3	0.0
Hayfever, allergic rhinitis or eczema	0.9	1.9	3.8	-1.6	0.4	-0.9	2.0
Multivitamins +/- minerals	0.5	0.6	1.2	-1.1	0.5	-0.8	0.6
Stomach or abdominal pain in last month	0.6	0.7	1.1	-0.8	0.5	1.0	-1.1
Supplements: Glucosamine	0.7	0.9	2.6	-1.6	-0.4	0.7	0.6
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.1	-0.7	1.0	0.9	0.2
Medication: Atenolol	0.7	0.9	1.5	1.2	-1.0	1.1	-0.2
Medication: Levothyroxine sodium	1.6	2.7	5.0	-2.2	2.2	-0.3	-1.0
Sitting height	0.4	2.8	8.1	-2.8	-0.2	-1.1	1.3
Chronic bronchitis/emphysema (father)	1.4	1.6	2.7	-1.6	1.6	0.4	-1.1
High blood pressure (mother)	1.2	1.7	4.3	0.7	0.4	2.1	-1.4
Body mass index (BMI)	2.4	10.1	34.4	-5.9	1.7	-0.4	1.7
Impedance of leg (left)	0.6	2.8	8.1	-0.6	1.6	-0.1	-2.8
Leg predicted mass (left)	1.7	8.8	19.4	-4.4	0.0	-0.9	3.8
Trunk fat mass	5.4	23.0	77.6	-8.8	3.3	-0.4	1.8
Waist circumference	2.9	10.7	33.2	-5.8	1.7	-1.4	2.2
Number of incorrect matches in round	0.4	0.6	1.1	1.1	-0.7	-0.7	0.5
Past tobacco smoking	1.0	1.9	5.1	2.2	-1.4	0.7	0.3
Alcohol usually taken with meals	1.4	2.3	4.7	2.0	-0.5	2.2	-0.5
Nervous feelings	0.2	0.3	0.8	0.4	-0.9	0.5	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.1	1.1	-0.5	0.4	-0.5
Hearing difficulty/problems with background noise	0.1	0.2	0.4	-0.7	-0.4	-0.0	-0.2
Hair/balding pattern: Pattern 2	1.1	1.4	4.7	-0.4	0.5	-2.2	-0.8
Had menopause	0.9	1.1	2.3	-1.5	0.2	1.1	-0.9
Had other major operations	0.3	0.4	1.0	0.3	0.4	0.6	-1.0
Forced vital capacity (FVC)	0.4	1.7	5.8	-2.4	-0.0	-1.0	0.4
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	4.1	1.8	-1.3	-2.0	0.5
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	1.5	-1.2	1.2	-0.9	0.1
Qualifications: None of the above	2.4	5.2	16.4	-0.3	-2.0	-4.0	0.6
Financial difficulties in last 2 years	2.6	3.5	7.7	-2.8	1.5	-0.0	-2.0
Mouth/teeth dental problems	2.3	3.5	8.1	-0.3	-0.8	-2.3	2.9
Heart attack	1.6	2.0	4.0	-0.7	-1.3	-1.4	2.0
Allergy	1.3	3.0	5.7	1.0	1.0	2.0	-2.4
Pain all over the body in last month	0.9	1.0	2.0	-1.4	-0.2	-0.4	1.4
Diabetes (self-reported)	0.9	1.4	5.3	-0.3	-0.2	-0.6	2.3
Hayfever/allergic rhinitis (self-reported)	0.5	0.6	2.0	-0.0	-0.7	-1.4	-0.0
Medication: Ramipril	0.8	1.0	2.8	-1.7	1.0	0.3	0.3
Medication: Simvastatin	0.5	0.7	1.4	-0.0	0.1	-1.1	1.2
Fluid intelligence score	1.2	2.6	4.5	0.7	1.1	2.0	-2.1
Illnesses of siblings	0.8	1.1	2.9	1.0	-0.5	-1.7	-0.6
Neuroticism score	0.2	0.5	0.9	-0.6	-0.9	0.3	0.8
Weight	3.1	15.4	48.6	-7.0	1.3	-1.0	3.2
Impedance of arm (right)	1.2	5.5	10.9	-1.3	3.3	1.8	-2.5
Arm fat percentage (right)	4.0	15.8	52.8	-7.3	2.8	0.2	1.5
Trunk fat-free mass	1.5	8.6	19.9	-2.3	-2.6	-1.6	4.5
Hip circumference	3.7	15.9	51.4	-7.2	3.2	-0.4	1.3
Time employed in main current job	0.9	1.1	2.2	0.6	-0.5	1.2	1.5
Alcohol intake versus 10 years previously	0.4	0.6	1.2	1.1	-0.1	-0.9	0.7
Father’s age at death	0.5	0.7	1.5	1.2	-0.4	-0.9	-0.4
Worrier / anxious feelings	0.7	1.4	4.5	0.5	-0.8	2.1	0.4
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	3.9	-1.6	-0.3	2.0	-0.5
Falls in the last year	0.4	0.5	1.2	-1.1	0.1	-0.9	0.3
Hair/balding pattern: Pattern 3	0.8	1.1	2.3	0.9	-1.2	0.2	1.5
Number of live births	1.1	1.6	5.5	0.2	-0.7	-0.5	-2.4
Forced expiratory volume in 1-second (FEV1)	0.1	0.4	1.2	-1.1	-0.4	-0.3	-0.4
Pulse rate	1.2	2.0	5.5	-2.4	-0.1	0.2	1.6
Happiness	0.5	0.6	1.2	-0.0	-1.0	1.1	0.1
Noisy workplace	1.0	1.2	2.0	1.3	-1.4	0.7	0.9
Qualifications: A levels/AS levels or equivalent	1.9	4.2	8.1	-0.0	2.9	2.4	-1.8
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.8	0.2	1.7	0.0	-0.7
Mouth/teeth dental problems: Dentures	1.2	2.1	3.0	1.4	-1.7	-0.9	1.5
Asthma	0.3	0.6	1.2	-0.3	-0.6	-1.0	1.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.7	-0.0	-0.2	0.8	-0.5
Medication: Cholesterol lowering	1.0	1.6	5.8	-0.8	0.3	-0.1	2.4
Depression (self-reported)	0.6	0.7	1.5	-0.9	-0.7	1.2	0.0
Medication: Lansoprazole	0.3	0.3	0.8	-0.9	0.5	0.3	-0.2
Prospective memory result	0.5	0.6	1.0	1.0	-0.4	-0.2	1.0
Lung cancer (father)	1.5	1.8	2.9	-1.1	-0.4	-1.7	1.7
Illnesses of mother	0.2	0.3	0.6	0.7	0.8	-0.0	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.0	0.1	0.1	-0.4	-0.3	0.2	-0.3
Pulse wave Arterial Stiffness index	0.2	0.3	0.5	-0.7	-0.3	0.4	0.6
Impedance of arm (left)	1.8	8.5	15.3	-1.7	3.9	2.1	-3.4
Arm fat mass (right)	3.9	15.9	53.9	-7.3	2.3	-0.1	2.1
Trunk predicted mass	1.6	9.0	20.7	-2.4	-2.6	-1.7	4.5
Standing height	0.6	6.1	12.0	-3.2	-0.6	-1.2	3.5
Length of working week for main job	0.3	0.4	0.7	0.8	0.3	0.3	-0.8
Exposure to tobacco smoke at home	2.8	3.1	4.1	-1.8	-1.5	-1.7	2.0
Breastfed as a baby	0.6	0.8	1.4	0.3	-0.7	1.2	-1.0
Tense / ‘highly strung’	0.7	1.1	1.5	0.5	-1.2	1.2	1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.7	1.1	2.4	-1.6	1.0	1.0	-0.1
Hair/balding pattern: Pattern 4	0.9	2.1	4.8	1.7	-0.8	2.2	-0.3
Birth weight of first child	0.6	1.0	2.3	0.2	0.8	1.5	-1.1
Peak expiratory flow (PEF)	0.6	1.3	3.0	-1.1	0.6	-0.8	-1.7
Pulse wave reflection index	0.2	0.3	0.8	0.4	0.2	-0.9	0.1
Ever highly irritable/argumentative for 2 days	1.4	1.7	2.6	-1.3	0.2	-1.6	1.6
Loud music exposure frequency	3.0	3.2	7.4	0.3	-1.5	-1.8	2.7
Qualifications: O levels/GCSEs or equivalent	3.3	5.3	8.5	-0.2	2.6	2.9	-2.4
Mouth/teeth dental problems: Bleeding gums	3.5	4.6	8.7	-3.0	1.9	0.6	-2.4
Blood clot in the leg (DVT)	1.3	1.7	3.2	0.1	-1.8	-1.8	0.5
Medication: Paracetamol	2.1	3.5	7.9	-0.4	1.5	2.0	-2.8
Headache pain in last month	0.8	1.4	4.3	0.4	-0.3	0.9	-2.1
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	4.6	0.5	0.2	-1.1	-2.1
Glaucoma (self-reported)	0.6	0.7	2.3	1.5	0.6	-0.3	0.2
Gout (self-reported)	0.1	0.1	0.3	-0.2	-0.1	-0.3	-0.5
Hypothyroidism/myxoedema (self-reported)	2.5	4.8	9.4	-2.8	3.1	-1.0	-1.1
Medication: Amlodipine	1.4	2.0	6.7	0.8	-0.7	2.6	-0.5
Medication: Ventolin 100micrograms inhaler	0.4	0.4	0.8	-0.9	0.0	-0.5	0.9
Birth weight	0.7	1.6	2.2	-0.9	1.5	1.2	-1.3
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.3	-0.2	0.4	0.4	-0.6
High blood pressure (siblings)	1.0	1.4	3.8	-0.7	1.1	1.9	0.2
Forced vital capacity (FVC), Best measure	0.2	0.7	2.3	-1.5	0.6	0.3	-0.1
Body fat percentage	5.6	22.2	72.6	-8.5	3.9	0.1	1.0
Leg fat percentage (right)	4.5	16.3	54.2	-7.4	3.2	-0.3	0.8
Arm fat-free mass (right)	1.7	8.5	13.9	-3.7	-1.5	-2.0	3.7
Exposure to tobacco smoke outside home	0.8	1.0	3.4	-1.8	0.7	-0.2	-0.2
Comparative body size at age 10	0.4	1.2	1.8	-1.2	1.1	0.2	1.3
Number of full brothers	1.0	1.2	4.3	-0.2	0.6	-0.3	-2.1
Worry too long after embarrassment	0.4	0.7	1.6	-0.2	-1.0	0.3	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	5.2	-2.3	0.6	0.1	-0.0
Wheeze or whistling in the chest in last year	0.2	0.4	0.8	-0.2	0.8	-0.9	-0.2
Number of children fathered	0.8	0.9	2.2	1.1	-0.2	1.5	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	2.5	2.9	7.4	0.9	-1.0	-1.5	2.7
Age at first live birth	1.0	1.8	6.1	-0.0	0.1	-1.1	2.5
Pulse wave peak to peak time	0.1	0.2	0.3	0.6	0.1	-0.6	-0.1
Health satisfaction	1.8	2.4	7.5	-1.3	-0.3	-0.4	2.7
Shortness of breath walking on level ground	1.8	2.2	3.8	-1.9	1.9	1.2	-0.3
Qualifications: College or University degree	0.6	1.9	4.8	0.4	1.6	2.2	-0.2
Eye problems/disorders: None of the above	0.7	0.8	1.6	-1.2	-0.2	-0.8	1.0
Mouth/teeth dental problems: Loose teeth	5.7	6.8	15.7	-0.9	3.0	1.3	-4.0
Emphysema/chronic bronchitis	0.5	0.6	1.0	-1.0	0.5	-0.7	0.9
Medication for pain relief, constipation, heartburn	0.3	0.6	1.5	0.1	0.2	-1.2	0.9
Neck or shoulder pain in last month	1.5	2.1	6.0	1.2	-0.7	2.5	-0.7
Medication: Blood pressure	0.7	1.3	3.8	-0.9	-0.0	0.7	1.9
Angina (self-reported)	0.6	0.8	2.5	0.7	0.1	1.6	0.4
Migraine (self-reported)	0.1	0.2	0.5	0.1	-0.4	0.7	-0.2
Medication: Ibuprofen	0.4	0.4	1.4	0.1	-0.3	1.2	-0.5
Medication: Allopurinol	0.5	0.7	1.3	-0.8	0.8	-1.1	-0.5
Medication: Omeprazole	0.2	0.2	0.6	-0.4	-0.2	0.8	-0.4
Medication: Seretide 50 evohaler	0.6	0.7	1.6	-0.6	0.0	-1.3	0.8
Mean time to correctly identify matches	1.9	3.6	10.0	-0.3	3.2	0.5	-2.1
Heart disease (mother)	0.6	0.7	1.1	0.4	-1.1	0.8	1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.2	-0.0	0.5	-1.1	-1.0
Whole body fat mass	5.3	22.2	74.5	-8.6	3.3	-0.4	1.8
Leg fat mass (right)	4.7	18.4	61.9	-7.9	2.9	-0.4	1.8
Arm predicted mass (right)	1.5	7.7	13.5	-3.7	-1.4	-1.7	3.5
Pulse rate, automated reading	2.0	6.4	18.7	-4.3	-0.0	-0.0	2.6
Alcohol intake frequency.	0.0	0.1	0.2	0.4	0.2	0.1	-0.3
Comparative height size at age 10	0.8	4.4	8.7	-2.8	-0.9	0.3	3.0
Number of full sisters	2.2	2.7	6.2	-0.5	1.7	1.1	-2.5
Suffer from ‘nerves’	0.7	1.1	3.4	0.3	-1.8	-0.4	0.9
Overall health rating	0.8	1.8	3.6	-1.9	1.5	0.7	-0.8
Chest pain or discomfort	0.2	0.3	0.6	-0.3	-0.7	0.3	0.8
Had major operations	0.3	0.4	0.6	-0.6	-0.2	0.7	-0.8
Age at last live birth	1.3	1.9	4.6	0.4	-0.3	-1.7	2.1
Family relationship satisfaction	0.5	0.6	1.6	0.6	-0.1	1.2	-0.5
Leg pain on walking	0.7	0.9	3.0	0.6	-0.6	0.1	1.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.0	-0.1	-1.0	0.9	-0.2
Commuting to job workplace: Car/motor vehicle	1.1	1.2	4.5	-2.1	0.3	0.4	-0.5
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	1.9	1.4	-0.9	0.8	0.6
Medication: Aspirin	1.8	2.4	4.0	1.3	-2.0	-0.5	1.9
Supplements: Vitamin C	0.9	1.1	1.9	-1.0	1.2	0.1	-1.4
Knee pain experienced in last month	0.7	1.0	1.8	-1.3	1.0	1.2	0.2
Hypertension (Self-reported)	0.6	1.5	6.0	0.2	0.2	2.4	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	0.6	-0.7	-0.8	0.5	-0.7
Illnesses of father: Heart disease	0.7	1.0	2.7	-0.0	-1.1	1.6	-0.3
Illnesses of siblings: Diabetes	0.4	0.5	1.1	0.6	-0.4	0.6	1.1
Smoking status: Previous	0.5	0.7	1.8	-1.3	0.9	-0.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.9	3.9	-0.6	-1.2	-1.3	2.0
Whole body fat-free mass	1.5	8.7	18.9	-3.3	-1.6	-1.5	4.3
Leg fat-free mass (right)	1.6	8.3	16.3	-4.0	-0.5	-1.2	3.9
Arm fat percentage (left)	4.4	17.7	58.7	-7.7	3.4	0.3	1.0
Average weekly red wine intake	0.0	0.0	0.0	-0.1	0.1	0.2	-0.2
Handedness (chirality/laterality): Left-handed	1.1	1.3	2.4	0.6	-0.8	-1.6	1.3
Mood swings	0.7	1.3	2.7	-1.6	-0.6	-0.3	1.4
Loneliness, isolation	1.1	1.5	3.6	0.5	-1.4	0.1	1.9
Long-standing illness, disability or infirmity	0.4	0.6	1.5	-0.8	-0.1	0.3	1.2
Ever had bowel cancer screening	0.9	1.0	2.4	-0.8	1.6	0.4	-0.9
Diabetes diagnosed by doctor	0.8	1.4	4.4	-0.9	-0.3	-0.6	2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.4	1.6	4.8	0.9	-2.2	-0.6	0.5
Friendships satisfaction	0.0	0.0	0.1	-0.1	-0.3	0.1	0.1
Qualifications: nursing, teaching	1.6	2.6	5.5	-0.9	2.3	1.7	-1.0
Commuting to job workplace: Walk	1.6	1.7	3.0	0.0	1.7	1.7	-0.9
Eye problems/disorders: Cataract	0.2	0.2	0.6	-0.0	0.1	-0.8	-0.5
Mouth/teeth dental problems: Mouth ulcers	3.4	5.4	15.3	1.0	1.5	1.7	-3.9
Medication for cholesterol	1.0	1.5	3.5	-0.9	1.9	-0.3	-1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.3	8.3	-2.9	0.9	-0.3	0.0
Back pain experienced in last month	0.2	0.3	0.8	-0.9	0.2	-0.4	-0.0
Mineral and other dietary supplements	0.4	0.5	1.7	1.3	0.4	-0.1	0.1
Breast cancer (self-reported)	0.2	0.2	0.8	0.9	-0.1	-0.1	-0.3
Asthma (self-reported)	0.5	0.9	2.0	-0.6	-0.3	-1.4	1.1
Osteoporosis (self-reported)	0.8	1.0	2.5	0.1	0.9	-1.6	-0.8
Osteoarthritis (self-reported)	0.3	0.4	0.5	-0.6	0.7	0.6	0.6
Medication: Aspirin	2.5	3.2	5.9	1.2	-2.0	-1.2	2.4
Medication: Gliclazide	1.0	1.1	3.8	-0.0	-0.1	-0.9	1.9
Illnesses of father: None of the above (group 1)	0.8	0.9	3.0	0.4	-0.6	-1.7	-0.5
Smoking status: Current	0.3	0.5	1.4	-1.2	0.5	-0.4	0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.2	3.0	0.8	-0.6	1.7	-0.9
Whole body water mass	1.5	8.7	19.4	-3.2	-1.7	-1.5	4.4
Leg predicted mass (right)	1.5	8.1	15.6	-4.0	-0.5	-1.1	3.9
Arm fat mass (left)	3.9	16.1	54.3	-7.4	2.5	-0.3	2.0
Number of self-reported non-cancer illnesses	0.7	1.3	3.9	-1.0	0.5	2.0	-0.2
Average weekly champagne plus white wine intake	0.8	1.1	2.9	1.7	-0.6	0.8	0.6
Miserableness	0.4	0.8	1.1	-0.7	-0.9	1.1	-0.7
Guilty feelings	1.8	2.7	6.8	-0.3	-1.2	-1.6	2.6
Wears glasses or contact lenses	0.6	0.7	1.8	1.4	-0.6	0.6	0.7
Ever taken oral contraceptive pill	1.2	1.3	3.2	1.2	-1.8	-0.2	0.9
Hearing aid user	0.4	0.4	0.9	-0.6	0.5	0.3	-0.9
Mother’s age at death	0.4	0.5	1.3	-0.1	-1.2	-0.8	0.2
Financial situation satisfaction	0.2	0.2	0.6	0.2	-0.1	-0.5	0.8
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.0	0.8	0.9	0.2	-1.0
Commuting to job workplace: Public transport	0.9	1.1	2.4	-0.6	1.5	-1.0	0.8
Eye problems/disorders: Glaucoma	0.8	0.9	2.9	1.7	-0.1	-0.8	0.5
Medication: Blood pressure	1.4	2.6	4.7	2.2	-1.1	1.8	1.0
Pain type(s) experienced in last month: Hip pain	1.9	2.4	4.2	-1.8	2.1	0.6	-1.3
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.3	-1.1	-0.9	-1.1	0.6
High cholesterol (Self-reported)	0.1	0.1	0.4	-0.1	0.2	0.6	-0.3
Medication: Bendroflumethiazide	1.6	2.4	4.5	2.1	0.4	2.1	0.9
Medication: Paracetamol	1.1	1.7	3.1	0.6	0.6	1.8	-1.7
Medication: Lisinopril	2.0	2.6	7.4	0.3	-1.5	-0.5	2.7
Medication: Atorvastatin	0.4	0.4	1.6	-0.1	0.1	1.2	0.4
Illnesses of father: High blood pressure	2.2	2.7	6.2	0.2	1.5	2.5	-1.5
Alcohol drinker status: Never	0.9	1.1	1.8	1.3	-0.7	-1.2	-0.7
Ever smoked	2.6	4.5	8.2	-2.9	2.6	-1.0	-1.4
Basal metabolic rate	1.7	9.6	18.0	-4.2	-0.9	-1.3	4.2
Leg fat percentage (left)	4.2	15.3	52.0	-7.2	2.8	-0.7	1.0
Arm fat-free mass (left)	1.9	9.8	19.8	-3.3	-1.9	-2.2	4.5
Number of operations (self-reported)	0.2	0.3	0.9	0.1	-0.3	0.9	0.3
Average weekly beer plus cider intake	0.1	0.2	0.5	-0.3	-0.5	-0.7	0.3
Irritability	0.2	0.4	0.7	-0.2	-0.8	-0.8	0.3
Risk taking	1.1	1.6	2.1	-1.2	-0.8	-1.5	1.4
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.5	-1.1	-0.2	-0.1	1.2
Fractured/broken bones in last 5 years	0.1	0.1	0.3	-0.1	0.5	0.3	-0.5
Age started oral contraceptive pill	0.8	1.0	2.6	1.6	-0.4	0.9	-0.6
Diastolic blood pressure, automated reading	0.3	0.9	2.3	-0.5	-0.8	1.5	0.6
Ever depressed for a whole week	1.8	2.2	5.4	-2.3	1.8	-0.1	-0.3
Unable to work because of sickness or disability	1.8	2.3	6.5	-1.3	2.5	0.2	-1.0
Commuting to job workplace: Cycle	0.5	0.7	1.6	-1.3	-0.3	-0.4	-0.9
Myopia	0.8	1.1	3.4	-1.8	1.0	0.1	0.2
Vascular/heart problems diagnosed by doctor	0.4	1.0	3.0	-0.7	0.4	-1.7	-0.5
Cholesterol lowering medication	0.6	0.9	2.0	0.9	-1.4	-0.7	0.5
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.4	-0.9	0.7	1.2	-0.9
Pain experienced in last month	0.4	0.6	1.4	1.2	0.6	-0.8	0.1
Supplements: Calcium	0.9	1.0	1.6	-0.0	-1.2	-1.3	0.9
Basal cell carcinoma (self-reported)	3.0	3.5	7.6	-0.2	-1.1	-2.3	2.8
Heart attack/myocardial infarction (self-reported)	2.0	2.6	5.4	-0.9	-1.4	-1.5	2.3
Deep venous thrombosis (DVT) (self-reported)	1.7	2.1	4.2	-0.1	-1.9	-2.0	0.9
Heart disease (siblings)	0.1	0.1	0.2	-0.4	-0.5	0.1	0.3
Alcohol drinker status: Previous	0.1	0.1	0.2	0.0	0.4	-0.1	-0.4
Pack years of smoking	1.2	1.8	3.5	-0.9	-1.1	-1.9	1.2
Impedance of whole body	1.2	6.3	11.7	-1.4	3.2	1.0	-3.4
Leg fat mass (left)	4.7	18.3	61.3	-7.8	2.6	-0.7	2.1
Arm predicted mass (left)	1.8	9.3	19.4	-3.2	-1.9	-1.9	4.4