Hub : Genes

KNTC1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0700	0.0270	6.5e-05	0.062	0.029	0.046	0.038	0.050	5.1e-08	0.00015	2.3e-06	1.9e-05	9.5e-07
2	GTEx	Nerve Tibial	0.1200	0.0441	4.4e-04	0.049	NA	0.043	NA	0.050	2.1e-04	NA	5.2e-04	NA	1.9e-04
3	GTEx	Skin Not Sun Exposed Suprapubic	0.1140	0.0490	5.3e-03	0.037	NA	0.019	NA	0.032	3.9e-03	NA	2.9e-02	NA	7.1e-03
4	METSIM	Adipose	0.0474	0.0252	4.9e-03	0.025	0.014	0.017	0.018	0.007	1.1e-04	0.00250	1.2e-03	8.7e-04	2.5e-02
5	TCGA	Brain Lower Grade Glioma	0.0515	0.0337	3.2e-03	0.009	0.020	0.005	NA	0.009	2.9e-02	0.00240	8.0e-02	NA	3.1e-02
6	TCGA	Soft Tissue Sarcoma	0.2990	0.1170	8.5e-03	0.007	0.043	0.027	NA	0.027	1.2e-01	0.00130	9.0e-03	NA	9.3e-03

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	1.7	2.8	7.8	0.1	-2.8	-2.5	0.5	-1.5	0.4
Bipolar Disorder or Schizophrenia	1.2	2.8	5.5	-0.8	-2.3	-1.5	1.8	-1.6	1.7
Depressed Affect (Nagel 2018)	0.5	1.0	2.9	1.1	-0.9	-1.7	1.0	-0.2	0.5
Depression (Nagel 2018)	0.8	1.2	3.4	0.4	-1.8	-1.6	0.2	-0.8	0.7
Intelligence (Savage-Jansen 2018)	1.0	3.2	7.9	-0.2	2.8	2.7	0.2	1.9	-0.2
Neuroticism (Nagel 2018)	0.9	2.1	6.1	2.5	-0.3	-1.9	1.4	0.8	-0.1
Schizophrenia (2018)	0.7	1.5	3.4	-1.1	-0.7	0.1	1.7	-0.9	1.9
Schizophrenia vs Biploar Disorder	0.9	1.2	2.7	-0.4	1.0	1.6	-0.5	0.7	-1.6
Worry (Nagel 2018)	1.4	2.9	8.5	2.2	-2.0	-2.9	0.2	-0.3	-0.4
Alzheimer’s Disease (in mother)	1.4	1.6	6.2	-0.1	0.5	0.9	-2.5	0.1	-1.6
Alzheimer’s Disease (in father)	1.2	1.3	2.8	0.4	-1.7	-1.3	-1.6	-0.7	-0.6
Alzheimer’s Disease (including proxy)	1.9	2.8	10.5	-1.3	-0.9	0.4	-3.2	-1.1	-1.5
Crohns Disease (2017)	0.2	0.4	1.1	-0.4	-1.0	-0.5	-0.7	-0.8	-0.2
Irritable Bowel Disease (IBD)	0.0	0.0	0.1	-0.1	-0.3	-0.0	0.2	-0.1	0.2
Ulcerative Colitis (UC)	0.2	0.3	1.4	0.3	-0.1	-0.3	1.2	0.2	0.6
Major Depression (MDD)	0.4	0.4	1.1	1.0	0.6	-0.2	0.2	1.1	-0.2
Reaction Time	0.2	0.4	1.0	1.0	-0.2	-0.7	0.2	0.4	-1.0
Verbal and Numeric Reasoning (VNR)	1.0	2.5	6.9	-1.4	1.8	2.6	-1.3	0.5	-1.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Ovarian Cancer	0.4	0.5	1.2	0.5	0.7	-0.4	0.9	0.4	1.1
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.8	1.1	2.6	-1.6	-1.1	0.3	-0.9	-0.9	-1.1
Bipolar Disorder (2011)	5.4	5.2	12.4	-0.6	-3.5	-3.0	-1.2	-2.4	1.5
Body Mass Index (BMI) (2010)	1.6	2.2	5.7	-1.2	-2.4	-1.2	-0.6	-2.1	0.5
Coronary Artery Disease (CAD)	3.0	3.6	7.1	-1.6	-2.7	-0.7	-1.4	-2.3	-2.0
Crohns Disease (2012)	0.6	0.9	2.5	-1.2	-0.6	0.3	-1.6	-1.0	0.5
Mean Putamen Volume	0.4	0.5	1.0	0.2	-1.0	-1.0	0.4	-0.8	0.2
Fasting Glucose	0.2	0.2	0.8	0.5	0.1	0.4	-0.2	0.1	0.9
HbA1C	2.1	2.3	5.3	-1.0	-2.3	-1.3	-0.5	-1.5	-1.8
HDL Cholesterol	1.1	1.8	3.4	-0.1	-1.3	-1.5	1.8	-1.1	1.6
LDL Cholesterol	0.3	0.5	1.8	0.7	-0.2	-0.9	1.4	-0.0	-0.4
Lupus	0.6	0.9	1.9	-1.2	-0.4	-0.5	-0.1	-1.4	-1.3
Neuroticism (2016)	4.7	6.8	15.9	4.0	2.0	-1.1	3.0	3.2	-0.5
Primary Biliary Cirrhosis	0.7	0.9	3.4	0.5	0.2	-0.3	1.8	0.7	-1.2
Rheumatoid Arthritis	0.2	0.3	1.0	-0.4	0.4	0.5	1.0	-0.2	0.6
Schizophrenia (2014)	0.3	0.7	1.6	-1.3	-0.9	0.4	0.8	-0.7	0.7
Triglycerides	0.1	0.1	0.3	-0.0	-0.3	-0.4	0.1	-0.5	-0.5
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.8	-0.7	-0.5	-0.8	-0.1	-1.0	1.3
Ulcerative Colitis	0.1	0.2	0.5	-0.4	0.4	0.7	0.0	0.1	-0.3
Blood Eosinophil Count	0.2	1.4	2.9	-1.7	0.2	1.1	-1.3	-1.3	1.0
Blood Platelet Count	0.6	6.6	13.0	-3.6	0.9	3.3	-3.2	-1.5	-1.6
Blood Red Count	0.4	3.4	6.2	0.9	2.5	1.0	2.4	2.3	1.1
Blood White Count	0.4	3.1	7.5	2.7	-0.6	-2.5	0.8	1.0	1.6
Heel T-Score	0.2	1.4	3.1	-1.8	0.7	0.8	-0.4	-1.7	1.0
BMI	3.4	20.0	61.0	-2.4	-7.8	-5.4	0.8	-4.8	0.4
Height	0.5	10.0	22.5	0.4	-4.7	-4.0	3.3	-0.5	3.1
Waist Hip Ratio (WHR)	2.5	11.0	24.0	-0.6	4.3	4.5	-4.9	1.7	-0.1
Systolic Blood Pressure	0.4	2.2	6.8	0.1	2.6	1.8	0.0	1.4	-1.0
Smoking Status	0.1	0.3	0.7	-0.4	0.1	0.6	0.4	0.5	-0.8
Allergy or Eczema	0.9	2.3	6.7	-0.2	-2.6	-1.7	-1.3	-1.6	0.1
Cardiovascular Disease	0.3	1.1	4.2	0.7	-0.3	-1.3	2.0	0.1	-0.6
Hypothyroidism (self reported)	0.3	0.8	1.8	-0.7	-1.4	-0.5	0.9	-0.7	0.6
Respiratory disease	0.3	0.6	1.3	-0.9	-0.3	0.2	-0.8	-0.7	1.1
Type 2 Diabetes (T2D) (2018)	0.2	0.5	2.8	-0.1	0.1	0.1	1.7	0.0	-0.1
Lung FEV1/FVC ratio	0.4	1.9	4.4	0.7	1.8	1.1	-0.0	1.5	-2.1
Lung FVC	1.1	5.5	14.7	-3.8	-1.1	1.3	-2.3	-3.1	0.5
Neuroticism	1.4	3.5	9.5	2.5	-1.3	-3.1	1.8	0.3	0.1
Chronotype (morning person)	3.5	8.2	15.9	2.6	3.8	1.0	3.2	4.0	-0.6
Hair Pigment	0.0	1.4	3.6	-1.1	-1.2	-0.2	-1.9	-1.3	0.7
Tanning	0.1	0.8	4.4	-0.3	-0.1	0.2	2.1	0.4	-0.5
Hand grip strength (left)	0.8	2.1	4.1	-2.0	-1.3	0.1	-1.6	-2.0	-0.7
Number of treatments/medications taken	0.6	1.1	3.2	-0.5	-1.8	-1.2	-0.3	-1.3	-0.3
Average weekly spirits intake	1.4	1.8	3.0	1.3	-0.9	-1.7	1.4	0.0	1.7
Sensitivity / hurt feelings	4.9	8.4	19.2	4.4	1.6	-1.7	3.6	3.4	1.1
Frequency of depressed mood in last 2 weeks	1.7	2.4	5.7	0.9	-2.4	-2.3	-0.5	-1.5	-0.4
Hearing difficulty/problems: Yes	0.6	0.9	1.9	1.4	-0.3	-1.0	-0.5	0.8	-1.4
Relative age of first facial hair	1.2	2.5	5.2	1.4	2.3	1.5	0.0	1.9	1.5
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	5.6	-0.6	-1.5	-1.4	0.7	-1.5	2.4
Ever used hormone-replacement therapy (HRT)	0.4	0.5	1.6	-0.4	-0.6	0.2	-0.8	-0.3	-1.3
Ever had hysterectomy (womb removed)	0.8	0.9	4.9	-0.0	0.4	0.6	-0.2	0.3	-2.2
Systolic blood pressure, automated reading	0.1	0.3	0.7	-0.8	0.7	0.5	0.7	0.1	-0.4
Eye problems/disorders: Diabetes related eye disease	0.5	0.6	3.0	0.2	0.5	0.3	-0.1	0.5	-1.7
Angina	0.1	0.1	0.3	0.4	-0.2	-0.6	0.2	-0.0	0.0
Medication for hormone replacement therapy	0.6	0.7	2.0	0.2	-0.1	-0.7	1.4	-0.3	1.2
Vitamin and mineral supplements	0.3	0.4	1.8	-0.2	-0.4	0.3	-0.5	-0.4	-1.4
Supplements: Zinc	0.4	0.4	0.9	-0.1	-0.7	-0.7	-0.6	-0.5	1.0
Medication: Co-codamol	2.6	3.0	6.0	-1.5	-2.5	-1.3	-0.8	-2.4	1.4
Medication: Metformin	0.7	1.0	4.0	0.5	-0.6	-1.2	2.0	-0.3	-0.2
Diabetes (father)	0.3	0.4	0.9	0.2	-1.0	-1.0	-0.3	-0.3	0.1
Diabetes (mother)	0.8	1.0	3.9	1.2	-0.0	-0.2	-0.1	0.9	-2.0
Severe depression (siblings)	3.4	3.8	10.4	-0.2	-3.2	-2.8	-0.6	-2.0	-0.3
Pack years adult smoking proportion	0.1	0.1	0.5	0.3	0.5	0.0	0.0	0.7	-0.2
Impedance of leg (right)	0.7	3.4	8.9	-0.1	2.6	3.0	-1.8	0.8	-1.0
Leg fat-free mass (left)	2.9	15.3	44.7	-0.5	-6.7	-5.6	2.3	-2.8	1.4
Trunk fat percentage	3.0	12.1	39.9	-1.1	-6.3	-4.3	1.6	-3.2	0.1
Hand grip strength (right)	0.7	2.0	3.9	-2.0	-1.2	0.0	-1.5	-1.8	-1.0
Townsend deprivation index at recruitment	1.0	1.4	2.9	1.6	1.7	0.7	0.8	1.5	0.3
Current tobacco smoking	0.1	0.1	0.2	-0.5	-0.1	0.3	0.5	-0.3	-0.2
Average weekly fortified wine intake	1.3	1.6	4.1	1.6	-1.4	-2.0	0.8	0.3	-0.0
Maternal smoking around birth	1.1	1.6	3.3	-0.8	-1.1	-0.3	-1.8	-1.6	1.3
Fed-up feelings	0.2	0.3	0.6	0.2	-0.4	-0.8	0.6	-0.6	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	1.0	1.3	3.1	0.1	-1.8	-1.5	0.2	-1.3	0.7
Relative age voice broke	1.0	1.5	2.9	1.6	1.5	0.4	-0.2	1.7	1.2
Taking other prescription medications	0.9	1.4	4.0	0.0	-1.6	-2.0	1.1	-1.0	0.1
Age when periods started (menarche)	0.1	0.3	1.1	-0.1	0.0	-0.3	-0.6	-0.7	1.0
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	4.2	-1.5	-1.6	-0.4	-0.6	-2.0	-0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.0	-0.3	-1.3	-1.2	0.3	-1.3	1.4
Tinnitus: Yes, but not now, but have in the past	2.1	2.3	4.7	1.6	-0.5	-2.0	2.2	-0.0	1.4
Qualifications: CSEs or equivalent	0.4	0.5	1.1	0.2	0.9	1.0	-0.6	0.4	-0.6
Serious illness, injury or assault to yourself	0.7	0.9	2.7	0.1	-0.6	-1.0	1.0	-0.4	1.6
High blood pressure	0.7	1.9	7.3	1.5	0.5	-1.2	2.7	0.6	0.0
Hayfever, allergic rhinitis or eczema	0.9	2.0	4.9	-0.4	-2.2	-1.6	-0.6	-1.7	1.1
Multivitamins +/- minerals	1.0	1.2	4.0	0.7	0.5	-0.3	1.3	0.9	2.0
Stomach or abdominal pain in last month	1.5	1.8	5.1	1.3	-1.8	-2.3	1.0	-0.5	0.0
Supplements: Glucosamine	4.6	6.0	11.7	-3.4	-2.4	-0.3	-2.6	-3.4	0.5
Diverticular disease/diverticulitis (self-reported)	0.9	1.0	2.3	-0.6	-1.5	-0.9	-0.5	-1.5	0.5
Medication: Atenolol	0.6	0.7	2.0	0.3	0.7	0.5	0.7	0.9	-1.4
Medication: Levothyroxine sodium	0.9	1.5	4.5	0.3	-1.1	-1.4	2.1	-0.3	0.9
Sitting height	1.0	7.5	19.4	1.4	-3.4	-4.4	3.2	0.0	1.2
Chronic bronchitis/emphysema (father)	0.4	0.5	1.4	-0.0	-0.9	-1.2	0.5	-0.7	0.4
High blood pressure (mother)	0.6	0.9	2.3	0.5	0.0	-1.2	1.1	-0.1	1.5
Body mass index (BMI)	2.4	10.1	30.8	-1.1	-5.6	-4.1	1.8	-2.9	-0.2
Impedance of leg (left)	0.8	3.7	9.2	-0.7	2.6	3.0	-2.2	0.4	-0.8
Leg predicted mass (left)	2.9	15.4	44.9	-0.4	-6.7	-5.7	2.4	-2.7	1.4
Trunk fat mass	3.9	16.6	54.4	-1.4	-7.4	-5.2	1.8	-3.7	0.3
Waist circumference	1.7	6.1	20.5	-1.2	-4.5	-3.0	0.3	-2.3	0.2
Number of incorrect matches in round	2.2	3.6	8.8	2.2	-1.4	-3.0	0.9	0.5	-2.2
Past tobacco smoking	0.3	0.5	1.3	-0.7	-0.2	0.2	-0.8	-1.1	0.9
Alcohol usually taken with meals	0.5	0.8	1.6	-0.3	1.1	1.0	1.3	0.8	-0.5
Nervous feelings	0.9	1.7	4.0	1.9	-1.2	-2.0	0.9	-0.1	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.5	0.4	0.2	-0.5	0.7	0.2	0.6
Hearing difficulty/problems with background noise	0.1	0.1	0.4	0.0	-0.2	-0.4	-0.5	0.2	-0.6
Hair/balding pattern: Pattern 2	0.6	0.8	2.8	0.3	0.6	0.8	-1.7	0.6	-0.7
Had menopause	0.4	0.5	1.6	0.4	0.1	0.3	1.3	1.0	0.4
Had other major operations	0.4	0.4	1.0	1.0	-0.7	-0.4	-0.3	0.4	-0.9
Forced vital capacity (FVC)	1.6	6.2	13.9	-2.3	-3.7	-2.0	-0.8	-3.5	1.2
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.0	0.0	-0.6	-0.8	0.5	-0.6	1.0
Ever unenthusiastic/disinterested for a whole week	2.2	2.7	5.2	2.2	-2.3	-2.3	-0.1	-0.6	-0.4
Qualifications: None of the above	0.6	1.4	4.0	0.8	2.0	1.2	-0.1	1.3	-0.6
Financial difficulties in last 2 years	1.3	1.8	3.5	1.2	-0.5	-1.5	1.7	0.5	1.9
Mouth/teeth dental problems	2.2	3.4	9.4	-0.7	-3.1	-2.3	0.2	-2.2	-0.6
Heart attack	0.3	0.3	1.0	1.0	-0.1	-0.5	0.3	0.5	0.6
Allergy	0.6	1.3	3.6	0.6	1.3	0.8	0.7	1.1	-1.9
Pain all over the body in last month	2.3	2.5	5.9	-1.8	-1.5	0.1	-2.4	-1.9	-0.1
Diabetes (self-reported)	0.3	0.5	2.8	0.2	0.0	-0.5	1.7	0.2	-0.2
Hayfever/allergic rhinitis (self-reported)	1.0	1.3	3.7	-1.0	-1.2	-0.8	-0.6	-1.9	0.7
Medication: Ramipril	0.5	0.7	3.1	0.5	0.5	-0.3	1.8	0.6	0.3
Medication: Simvastatin	1.3	1.9	3.4	0.7	1.9	0.6	1.9	1.8	-0.3
Fluid intelligence score	0.3	0.6	1.6	-0.8	1.1	1.3	-0.3	0.3	-0.5
Illnesses of siblings	0.5	0.8	2.5	-0.1	0.5	1.1	-1.6	0.2	-0.9
Neuroticism score	0.8	1.7	4.3	1.8	-0.7	-2.1	1.4	-0.0	0.6
Weight	3.8	18.6	57.8	-1.3	-7.6	-5.7	2.2	-3.7	0.9
Impedance of arm (right)	0.1	0.4	0.8	-0.2	0.1	0.9	-0.8	-0.3	0.8
Arm fat percentage (right)	2.9	11.5	38.6	-1.5	-6.2	-3.9	1.3	-3.4	-0.3
Trunk fat-free mass	1.5	8.8	26.6	-0.9	-5.2	-4.2	1.5	-2.2	0.8
Hip circumference	3.5	15.0	44.4	-0.6	-6.7	-5.3	3.0	-2.8	0.5
Time employed in main current job	1.1	1.3	3.6	-1.2	-1.9	-0.5	-0.5	-1.4	-0.4
Alcohol intake versus 10 years previously	0.5	0.8	1.6	0.5	0.6	-0.0	-1.3	1.0	-1.2
Father’s age at death	1.2	1.6	4.2	1.7	1.1	-0.0	-0.4	2.0	-1.2
Worrier / anxious feelings	0.7	1.2	2.8	0.7	-1.3	-1.7	-0.5	-0.5	-1.4
Frequency of tiredness / lethargy in last 2 weeks	2.8	4.5	8.7	-0.1	-2.9	-3.0	-0.7	-2.6	1.6
Falls in the last year	0.9	1.2	3.7	1.0	-0.1	-1.1	1.9	0.3	1.2
Hair/balding pattern: Pattern 3	1.2	1.8	4.8	1.1	1.2	-0.1	2.2	1.4	1.0
Number of live births	1.3	1.9	4.6	-0.5	1.9	2.1	-1.0	0.7	-1.0
Forced expiratory volume in 1-second (FEV1)	0.9	2.9	6.8	-1.3	-2.6	-1.8	-0.2	-2.3	0.6
Pulse rate	3.5	5.9	13.7	-0.9	-3.7	-2.9	-1.2	-2.9	-1.6
Happiness	1.6	1.9	5.7	0.7	-1.9	-2.4	0.4	-1.3	0.2
Noisy workplace	1.4	1.8	3.7	1.1	1.9	0.4	1.6	1.4	1.2
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.5	0.1	-0.6	-0.5	0.7	-0.1	0.4
Serious illness, injury or assault of a close relative in last 2 years	4.2	4.8	9.6	2.9	-0.6	-3.1	2.9	0.7	1.1
Mouth/teeth dental problems: Dentures	1.1	1.8	5.1	0.8	2.3	1.3	0.3	1.8	0.3
Asthma	0.4	0.8	1.7	-0.2	1.1	1.1	-0.3	0.7	1.3
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.4	-0.1	0.3	0.6	-0.2	0.3	0.2
Medication: Cholesterol lowering	0.2	0.3	1.4	0.4	-0.2	-0.6	1.2	0.2	-0.1
Depression (self-reported)	3.3	3.9	9.7	0.4	-3.1	-2.9	-0.2	-2.1	1.0
Medication: Lansoprazole	2.8	3.2	5.2	-2.1	-2.0	-0.4	-2.3	-2.2	-0.7
Prospective memory result	1.4	1.8	4.8	1.0	0.9	0.8	0.8	2.2	-1.6
Lung cancer (father)	0.9	1.0	2.1	0.3	-1.5	-1.2	-1.1	-0.8	-0.8
Illnesses of mother	0.7	0.9	2.6	1.6	0.3	-0.2	0.3	1.1	-1.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	4.8	-1.6	-2.2	-1.1	-0.3	-1.9	0.2
Pulse wave Arterial Stiffness index	0.6	0.7	2.5	-1.6	0.1	1.2	-0.3	-0.5	-0.2
Impedance of arm (left)	0.1	0.3	0.4	0.7	0.4	0.6	-0.4	0.4	0.6
Arm fat mass (right)	3.9	16.0	51.9	-1.3	-7.2	-5.1	1.7	-3.7	0.1
Trunk predicted mass	1.6	9.1	27.4	-1.0	-5.2	-4.3	1.5	-2.3	0.7
Standing height	0.8	8.4	25.7	-0.6	-5.1	-3.9	0.8	-2.1	2.0
Length of working week for main job	1.2	1.3	2.9	-1.7	0.2	1.4	-1.4	-0.9	-0.6
Exposure to tobacco smoke at home	1.0	1.2	1.9	-1.1	-1.1	0.4	-1.4	-1.3	-0.9
Breastfed as a baby	0.2	0.3	0.7	0.8	-0.1	-0.3	0.0	0.6	-0.5
Tense / ‘highly strung’	1.7	2.8	7.2	0.5	-2.2	-2.7	-0.1	-2.0	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.0	3.0	8.4	0.4	-2.9	-2.5	-1.0	-1.5	-0.5
Hair/balding pattern: Pattern 4	0.2	0.5	1.0	-0.1	-0.7	-0.8	-0.1	-0.7	1.0
Birth weight of first child	0.3	0.6	2.1	-1.0	-0.1	0.3	0.3	-0.6	1.5
Peak expiratory flow (PEF)	0.2	0.6	1.5	-0.1	-1.2	-1.1	-0.2	-0.7	0.3
Pulse wave reflection index	0.9	1.1	3.5	-0.3	1.2	1.9	-0.5	0.7	0.8
Ever highly irritable/argumentative for 2 days	0.9	1.0	3.6	0.6	-1.0	-0.6	-0.9	-0.3	-1.9
Loud music exposure frequency	1.1	1.2	3.5	1.9	0.4	-0.6	1.1	1.2	0.7
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.9	0.5	0.8	0.4	1.0	0.8	0.7
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	5.7	-0.5	0.2	0.3	0.3	-0.1	2.4
Blood clot in the leg (DVT)	0.8	1.1	3.3	-1.8	-0.7	0.4	-0.8	-1.2	0.7
Medication: Paracetamol	1.3	2.2	4.8	-1.0	1.2	2.0	-2.2	-0.1	-1.3
Headache pain in last month	0.7	1.2	3.5	0.7	1.9	1.1	-1.1	1.0	0.2
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.8	-0.6	0.7	1.3	-0.5	0.1	0.1
Glaucoma (self-reported)	0.3	0.3	0.6	0.5	0.3	-0.2	-0.8	0.8	-0.3
Gout (self-reported)	0.1	0.2	0.5	0.7	0.5	-0.3	0.5	0.1	-0.0
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	2.2	-0.2	-1.5	-0.9	0.9	-0.7	0.4
Medication: Amlodipine	1.4	1.9	5.6	1.2	0.0	-1.2	2.4	0.3	1.8
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.9	-0.3	-0.3	0.0	-1.0	-0.4	0.1
Birth weight	0.5	1.0	3.6	-0.9	-0.7	-0.3	0.2	-1.1	1.9
Chronic bronchitis/emphysema (mother)	2.1	2.4	7.2	-0.2	-1.2	-1.2	1.9	-0.8	2.7
High blood pressure (siblings)	0.6	0.9	2.4	0.0	-0.9	-1.6	1.1	-0.8	0.3
Forced vital capacity (FVC), Best measure	1.5	5.6	12.1	-2.5	-3.5	-1.5	-0.9	-3.3	1.0
Body fat percentage	2.9	11.5	39.1	-1.4	-6.3	-3.9	1.4	-3.3	-0.4
Leg fat percentage (right)	2.6	9.4	30.5	-1.5	-5.5	-3.5	1.0	-3.2	-0.5
Arm fat-free mass (right)	1.6	8.3	25.1	-1.0	-5.0	-4.0	1.5	-2.3	0.3
Exposure to tobacco smoke outside home	0.5	0.7	1.8	0.7	0.9	0.6	0.7	1.3	-0.2
Comparative body size at age 10	0.2	0.6	1.6	1.0	-0.5	-1.3	0.5	0.9	-0.0
Number of full brothers	0.3	0.4	1.0	0.4	0.2	-0.1	-1.0	-0.4	1.0
Worry too long after embarrassment	1.9	3.2	5.4	2.1	2.0	0.0	2.2	2.3	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	4.0	5.2	10.4	-1.6	-3.2	-2.0	-2.0	-3.2	-0.3
Wheeze or whistling in the chest in last year	1.1	1.9	3.7	1.9	0.2	-1.6	1.1	0.8	1.9
Number of children fathered	2.0	2.3	5.1	1.4	1.8	0.9	1.5	2.3	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.4	0.8	0.5	-0.2	0.8	1.2	-0.7
Age at first live birth	0.3	0.5	1.3	-1.1	-0.9	-0.2	-0.4	-0.9	0.2
Pulse wave peak to peak time	0.8	0.9	2.9	1.7	-0.2	-1.3	0.6	0.7	0.3
Health satisfaction	2.6	3.3	8.4	0.3	-2.9	-2.8	0.0	-1.9	-0.4
Shortness of breath walking on level ground	2.1	2.5	6.7	0.5	-2.6	-2.4	-0.5	-1.3	0.4
Qualifications: College or University degree	0.8	2.5	7.6	-0.0	-1.6	-1.7	1.0	-0.9	2.8
Eye problems/disorders: None of the above	1.2	1.4	4.7	-1.1	-0.4	0.8	-1.2	-0.6	-2.2
Mouth/teeth dental problems: Loose teeth	4.1	4.9	13.2	1.1	3.6	2.2	1.0	2.9	1.1
Emphysema/chronic bronchitis	1.7	1.9	6.5	0.6	-1.9	-2.5	-0.4	-0.9	-0.2
Medication for pain relief, constipation, heartburn	0.9	1.6	5.6	1.3	-0.1	-1.1	2.4	0.9	0.6
Neck or shoulder pain in last month	0.5	0.6	1.5	0.6	0.4	-0.8	1.1	-0.1	1.2
Medication: Blood pressure	0.2	0.3	1.1	0.3	-0.7	-1.0	-0.1	-0.3	-0.4
Angina (self-reported)	0.1	0.1	0.4	0.4	-0.1	-0.6	0.4	0.0	0.2
Migraine (self-reported)	1.4	1.8	3.8	1.1	1.9	0.4	1.4	1.4	1.2
Medication: Ibuprofen	0.1	0.2	0.4	0.6	-0.0	-0.1	0.4	0.6	0.4
Medication: Allopurinol	0.4	0.6	1.1	1.1	1.0	0.3	0.7	0.8	-0.4
Medication: Omeprazole	1.0	1.1	1.9	-0.2	-1.4	-1.1	-1.1	-1.1	-1.1
Medication: Seretide 50 evohaler	0.5	0.5	2.5	0.1	-0.1	-0.1	0.7	0.4	1.6
Mean time to correctly identify matches	0.3	0.6	1.5	1.2	0.1	-0.4	0.6	0.9	-1.0
Heart disease (mother)	0.3	0.4	1.0	-0.3	0.7	0.4	1.0	0.4	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	3.6	-0.4	-0.4	0.0	-1.9	-0.7	-0.5
Whole body fat mass	3.9	16.4	53.1	-1.3	-7.3	-5.2	1.9	-3.7	0.1
Leg fat mass (right)	3.8	14.6	46.6	-1.4	-6.8	-4.8	1.6	-3.7	0.1
Arm predicted mass (right)	1.8	9.1	27.6	-1.0	-5.3	-4.2	1.4	-2.4	0.4
Pulse rate, automated reading	5.2	16.6	42.7	-2.8	-6.5	-3.7	-2.0	-5.5	-1.2
Alcohol intake frequency.	0.5	1.2	2.3	-0.1	-1.2	-1.5	-1.3	-1.1	0.8
Comparative height size at age 10	0.7	3.7	11.6	0.1	-3.4	-2.6	1.3	-1.0	1.0
Number of full sisters	0.4	0.5	1.4	-0.7	-0.1	0.4	-0.4	-0.9	1.2
Suffer from ‘nerves’	1.0	1.6	3.9	1.6	-1.3	-2.0	0.0	-0.2	-1.3
Overall health rating	1.0	2.2	6.2	1.2	-1.2	-2.5	1.6	-0.3	1.2
Chest pain or discomfort	0.5	0.8	2.2	1.5	0.3	-1.1	0.2	0.3	1.0
Had major operations	1.2	1.4	4.0	0.5	-0.0	-1.0	2.0	0.1	1.7
Age at last live birth	0.2	0.3	1.2	-1.1	-0.1	0.1	-0.4	-0.4	0.5
Family relationship satisfaction	0.1	0.2	0.5	-0.6	0.0	-0.0	0.1	-0.4	-0.7
Leg pain on walking	0.2	0.3	0.8	0.4	-0.4	-0.6	0.2	0.2	0.9
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.0	-0.2	-0.1	-0.2	0.7	-0.2	1.0
Commuting to job workplace: Car/motor vehicle	1.3	1.5	3.5	-1.9	-1.0	0.2	-1.5	-1.5	0.1
Illness, injury, bereavement, stress in last 2 years	3.0	3.6	11.3	-1.0	2.2	3.4	-1.2	1.0	-1.5
Medication: Aspirin	0.2	0.2	0.6	-0.0	0.8	0.6	-0.4	0.5	-0.0
Supplements: Vitamin C	0.9	1.0	2.0	-0.5	-1.1	-1.1	-1.4	-1.2	0.3
Knee pain experienced in last month	0.7	1.1	3.2	0.5	-1.8	-1.6	0.5	-0.5	0.4
Hypertension (Self-reported)	0.7	1.8	6.7	1.5	0.3	-1.3	2.6	0.5	-0.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	3.1	-0.5	-0.6	-0.1	-1.3	-1.1	-1.8
Illnesses of father: Heart disease	0.1	0.1	0.5	-0.1	-0.1	0.0	0.7	-0.2	0.2
Illnesses of siblings: Diabetes	1.3	1.6	4.4	2.1	0.6	-1.0	1.4	1.3	0.3
Smoking status: Previous	0.4	0.6	1.6	0.1	0.6	0.5	-0.1	1.3	-1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.6	1.3	2.8	-1.2	-1.7	-0.3	-1.3	-1.2	-0.3
Whole body fat-free mass	2.1	12.0	35.5	-0.9	-6.0	-5.0	1.9	-2.6	1.1
Leg fat-free mass (right)	2.7	14.6	41.6	-0.7	-6.5	-5.5	2.2	-2.8	1.7
Arm fat percentage (left)	2.8	11.3	38.3	-1.2	-6.2	-4.0	1.4	-3.1	-0.5
Average weekly red wine intake	0.8	1.2	6.1	-0.1	-0.7	0.4	0.8	0.2	-2.5
Handedness (chirality/laterality): Left-handed	0.8	0.9	2.6	1.4	0.2	-0.7	-0.2	0.8	-1.6
Mood swings	0.3	0.6	1.1	0.7	-1.0	-1.1	-0.2	-0.3	0.8
Loneliness, isolation	0.5	0.7	1.9	1.4	-0.6	-1.0	0.2	0.3	-1.0
Long-standing illness, disability or infirmity	0.6	1.0	1.6	-0.5	-1.3	-1.1	0.8	-1.2	0.8
Ever had bowel cancer screening	0.1	0.2	0.5	-0.7	0.1	0.3	0.4	-0.3	-0.3
Diabetes diagnosed by doctor	0.5	0.8	3.8	0.4	-0.2	-0.9	2.0	-0.0	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.2	0.8	0.3	0.0	0.1	0.1	0.1	-0.9
Friendships satisfaction	0.3	0.4	0.6	-0.5	-0.8	-0.5	0.3	-0.8	-0.7
Qualifications: nursing, teaching	1.7	2.7	7.2	0.1	-1.4	-2.1	1.2	-1.1	2.7
Commuting to job workplace: Walk	3.8	4.1	10.9	2.3	-0.1	-2.3	3.3	1.0	1.4
Eye problems/disorders: Cataract	1.0	1.2	2.7	1.3	-0.6	-1.4	0.7	0.0	1.6
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	5.7	0.4	2.4	2.3	-0.8	0.9	-0.2
Medication for cholesterol	0.4	0.6	2.6	-0.3	-0.3	0.0	-1.6	-0.2	0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	1.3	-0.8	-0.9	-0.2	-0.4	-1.0	1.1
Back pain experienced in last month	4.0	5.9	13.4	-0.8	-3.7	-2.9	-1.7	-3.0	1.0
Mineral and other dietary supplements	1.7	2.2	4.3	2.1	0.9	-0.6	2.0	1.8	-0.9
Breast cancer (self-reported)	0.6	0.7	2.2	0.6	-0.1	-0.5	1.5	-0.1	1.1
Asthma (self-reported)	0.4	0.8	2.2	-0.5	0.8	1.1	-0.6	0.3	1.5
Osteoporosis (self-reported)	0.5	0.6	1.9	-0.0	1.4	0.7	0.8	0.5	0.2
Osteoarthritis (self-reported)	1.2	1.6	3.3	-1.5	-1.3	0.2	-1.8	-1.4	-0.6
Medication: Aspirin	0.2	0.2	0.5	0.1	0.7	0.5	-0.4	0.6	-0.1
Medication: Gliclazide	0.6	0.7	3.1	0.1	0.5	0.2	1.8	0.8	0.3
Illnesses of father: None of the above (group 1)	0.6	0.7	1.3	0.6	0.5	0.4	-1.1	1.1	-0.9
Smoking status: Current	0.1	0.1	0.5	-0.1	-0.3	-0.0	0.7	-0.2	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.2	2.5	4.1	-1.8	-1.3	-0.0	-2.0	-1.9	-1.5
Whole body water mass	2.0	11.7	34.5	-0.9	-5.9	-4.9	1.9	-2.5	1.0
Leg predicted mass (right)	2.7	14.3	40.9	-0.8	-6.4	-5.4	2.1	-2.8	1.6
Arm fat mass (left)	3.5	14.2	46.0	-1.1	-6.8	-4.9	2.0	-3.3	-0.0
Number of self-reported non-cancer illnesses	0.6	1.0	1.7	-0.7	-1.1	-0.9	1.2	-1.3	0.5
Average weekly champagne plus white wine intake	2.1	2.8	6.5	2.3	0.1	-1.0	2.5	1.8	0.9
Miserableness	0.9	1.5	2.6	1.5	-0.0	-1.5	1.3	0.4	1.6
Guilty feelings	0.2	0.3	1.2	0.0	0.1	-0.2	1.1	-0.2	-0.8
Wears glasses or contact lenses	0.3	0.3	0.5	-0.6	0.5	0.7	0.2	0.6	-0.4
Ever taken oral contraceptive pill	1.1	1.2	2.5	1.3	0.0	-1.0	1.6	0.5	1.3
Hearing aid user	0.8	1.0	3.3	-0.3	-0.6	0.0	-1.8	-0.4	-1.3
Mother’s age at death	0.1	0.2	0.3	0.3	0.3	-0.3	0.5	0.5	0.3
Financial situation satisfaction	0.0	0.0	0.2	0.1	0.4	-0.1	0.1	0.2	-0.2
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.1	0.9	-0.6	-0.9	-0.4	-0.0	-1.1
Commuting to job workplace: Public transport	0.5	0.7	1.2	0.3	0.6	1.0	-0.4	1.1	-1.1
Eye problems/disorders: Glaucoma	0.7	0.8	2.4	0.7	1.2	0.5	0.3	1.5	0.1
Medication: Blood pressure	0.9	1.7	4.3	1.5	1.0	0.2	2.1	1.3	-0.8
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.4	-0.3	-0.3	-0.3	0.6	-0.1	0.5
Supplements: Fish oil (including cod liver oil)	1.1	1.5	3.1	-1.4	-0.4	0.6	-1.8	-1.4	1.1
High cholesterol (Self-reported)	0.8	1.4	2.7	0.1	1.6	1.2	0.9	1.1	-1.5
Medication: Bendroflumethiazide	0.5	0.8	1.6	0.6	0.9	1.0	0.5	1.3	-0.7
Medication: Paracetamol	1.4	2.1	5.7	-0.6	0.8	1.7	-2.4	0.1	-1.7
Medication: Lisinopril	0.3	0.4	0.9	-0.6	0.1	0.5	-1.0	-0.9	0.0
Medication: Atorvastatin	0.1	0.1	0.3	-0.0	-0.4	-0.5	0.5	-0.3	-0.2
Illnesses of father: High blood pressure	0.0	0.0	0.1	0.2	-0.1	-0.4	-0.1	-0.2	0.1
Alcohol drinker status: Never	0.2	0.3	0.8	-0.9	0.5	0.5	-0.3	-0.4	0.3
Ever smoked	0.6	1.0	1.8	1.1	0.3	-0.3	1.4	1.3	-1.1
Basal metabolic rate	2.6	14.5	43.3	-1.0	-6.6	-5.3	2.0	-2.9	1.1
Leg fat percentage (left)	2.6	9.5	29.7	-2.0	-5.5	-3.2	0.7	-3.4	-0.6
Arm fat-free mass (left)	2.0	9.9	28.8	-1.0	-5.4	-4.4	2.0	-2.4	0.5
Number of operations (self-reported)	0.2	0.3	1.3	-0.2	-0.1	-0.2	0.2	-0.2	1.1
Average weekly beer plus cider intake	0.7	1.1	2.3	1.3	0.8	-0.0	0.8	1.5	-1.0
Irritability	0.2	0.3	1.1	0.2	-0.1	-0.6	0.2	-0.6	1.0
Risk taking	1.6	2.3	5.9	1.2	-1.1	-2.4	1.9	0.1	1.3
Ever had prostate specific antigen (PSA) test	0.2	0.3	0.9	-0.1	-0.6	-0.6	1.0	0.1	0.0
Fractured/broken bones in last 5 years	0.2	0.3	1.1	0.5	-0.1	-0.4	0.5	0.3	1.1
Age started oral contraceptive pill	0.9	1.2	2.6	1.2	1.2	0.5	0.2	1.6	-1.1
Diastolic blood pressure, automated reading	0.8	2.5	6.8	-1.6	-1.7	-1.5	0.3	-2.6	0.9
Ever depressed for a whole week	1.2	1.5	4.2	0.7	-2.1	-1.9	0.0	-0.9	-0.5
Unable to work because of sickness or disability	1.9	2.4	6.5	0.7	-1.8	-2.6	-0.3	-1.4	1.6
Commuting to job workplace: Cycle	1.0	1.2	2.4	-1.2	0.5	1.6	-1.4	-0.8	-0.8
Myopia	0.4	0.5	1.6	0.6	-0.7	-0.9	1.2	-0.0	-0.0
Vascular/heart problems diagnosed by doctor	0.8	2.2	6.1	-1.8	-1.3	0.7	-2.5	-1.4	0.2
Cholesterol lowering medication	0.4	0.6	1.5	-0.5	1.0	1.2	0.2	0.1	-0.9
Medication: Omeprazole (e.g. Zanprol)	2.2	2.7	4.8	-0.4	-2.2	-1.7	-1.5	-2.0	-1.3
Pain experienced in last month	0.4	0.7	1.3	0.6	1.1	0.5	0.8	1.1	-0.3
Supplements: Calcium	1.1	1.2	2.9	-1.4	1.1	1.7	-0.5	-0.2	1.1
Basal cell carcinoma (self-reported)	4.8	5.7	13.8	2.8	1.7	0.8	0.9	3.7	-2.8
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.5	0.7	-0.4	-0.6	0.2	0.2	0.6
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	4.7	-2.2	-1.1	0.4	-1.3	-1.7	0.5
Heart disease (siblings)	1.3	1.6	4.9	-2.2	-0.8	0.1	-1.1	-1.7	0.1
Alcohol drinker status: Previous	1.3	1.5	3.7	0.9	-1.3	-1.9	0.9	-0.6	1.3
Pack years of smoking	0.2	0.3	0.8	0.7	0.5	-0.1	0.0	0.9	-0.2
Impedance of whole body	0.3	1.5	4.2	-0.1	1.6	2.1	-1.5	0.3	-0.2
Leg fat mass (left)	3.6	14.2	45.6	-1.6	-6.8	-4.6	1.5	-3.7	-0.0
Arm predicted mass (left)	2.0	10.4	31.3	-1.1	-5.6	-4.4	1.8	-2.6	0.4