TWAS hub - SNRNP35

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Colon Transverse	0.1850	0.0850	3.1e-03	0.016	NA	0.023	NA	0.038	5.4e-02	NA	2.8e-02	NA	6.5e-03
2	YFS	Blood	0.0492	0.0160	3.7e-07	0.028	0.029	0.026	0.029	0.027	1.6e-09	5.9e-10	4.4e-09	7.5e-10	2.5e-09
3	TCGA	Colon Adenocarcinoma	0.1370	0.0740	1.4e-03	0.049	0.046	0.049	NA	0.045	8.1e-04	1.2e-03	7.9e-04	NA	1.3e-03
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0334	0.0214	3.8e-03	0.026	0.016	0.003	NA	0.009	6.0e-04	5.9e-03	1.4e-01	NA	2.7e-02
5	TCGA	Prostate Adenocarcinoma	0.0624	0.0312	2.1e-04	0.021	0.031	0.017	NA	0.024	2.6e-03	2.9e-04	5.8e-03	NA	1.4e-03
6	TCGA	Testicular Germ Cell Tumors	0.2310	0.0990	3.6e-03	-0.008	0.019	0.036	NA	0.000	8.2e-01	6.7e-02	2.0e-02	NA	3.1e-01
7	TCGA	Thyroid Carcinoma	0.0400	0.0210	1.4e-03	0.040	0.018	0.016	NA	0.020	8.2e-05	6.0e-03	1.0e-02	NA	4.2e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Waist Hip Ratio (WHR)	5.3	23.7	91.0	-9.5	-7.4	-2.0	2.9	-1.7	2.3	0.3
Average weekly red wine intake	4.3	6.4	18.3	-1.5	0.8	-2.2	-4.3	-3.2	1.1	-2.7
Leg fat percentage (left)	4.2	15.2	46.9	6.8	3.8	2.0	2.9	4.0	-3.8	1.3
Arm fat percentage (left)	4.1	16.2	52.1	7.2	4.2	2.7	2.6	3.3	-3.9	1.7
Body fat percentage	3.9	15.6	53.6	7.3	4.5	2.2	2.2	3.1	-3.7	1.3
Leg fat percentage (right)	3.9	14.1	44.8	6.7	3.6	2.2	2.8	3.6	-3.6	1.5
Sitting height	3.8	26.8	92.2	0.7	-1.3	-3.2	-9.6	-6.3	4.7	-4.6
Arm fat percentage (right)	3.7	14.5	48.0	6.9	4.0	2.5	2.4	3.0	-3.7	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.7	4.3	7.6	2.6	2.6	0.7	1.4	2.6	-2.8	0.4
Leg fat mass (left)	3.3	12.9	54.3	7.4	3.1	1.8	1.4	3.2	-3.2	0.9
Trunk fat percentage	3.2	12.6	46.0	6.8	4.5	2.0	1.7	2.2	-3.0	1.1
Qualifications: O levels/GCSEs or equivalent	3.1	5.0	14.3	-0.7	-0.6	-1.9	-3.8	-2.9	2.0	-1.9
Leg fat mass (right)	3.1	12.2	52.8	7.3	2.8	2.0	1.4	3.0	-3.0	1.0
Ever smoked	3.0	5.3	11.1	-1.7	-1.0	-2.2	-3.3	-3.0	2.0	-1.9
Past tobacco smoking	2.9	5.4	8.0	2.6	1.5	2.5	2.8	2.8	-1.8	2.0
BMI	2.8	16.5	58.7	7.7	3.7	2.0	2.0	4.7	-3.3	1.4
Height	2.8	54.7	153.9	-1.0	-5.1	-4.8	-12.4	-10.6	5.3	-6.2
Maternal smoking around birth	2.8	4.1	9.4	-3.1	-2.4	-2.1	-1.0	-0.8	2.5	-1.2
Body mass index (BMI)	2.8	12.1	44.6	6.7	3.0	1.5	1.4	3.7	-3.6	0.6
Pain type(s) experienced in last month: Hip pain	2.8	3.5	8.7	0.7	0.3	-2.4	-1.6	0.8	-2.4	-2.9
Hip circumference	2.7	11.8	60.2	7.8	3.6	1.3	-1.4	1.3	-2.0	0.0
Pulse wave Arterial Stiffness index	2.7	3.2	8.0	-1.8	-1.9	-1.2	-1.8	-2.8	0.1	-1.7
Whole body fat mass	2.7	11.1	50.7	7.1	3.2	1.6	0.6	2.0	-3.1	0.5
Qualifications: College or University degree	2.6	8.3	24.3	-0.4	2.4	-3.1	-4.9	-2.7	1.2	-3.1
Comparative height size at age 10	2.6	14.1	43.3	0.9	-1.9	-2.2	-6.6	-5.5	2.0	-3.4
Illnesses of father: High blood pressure	2.6	3.2	9.7	1.6	3.1	1.3	1.9	1.5	-0.1	1.6
Trunk fat mass	2.5	10.9	50.7	7.1	3.6	1.6	0.3	1.5	-2.8	0.4
Qualifications: A levels/AS levels or equivalent	2.5	5.6	18.6	0.5	2.2	-1.8	-4.3	-2.3	1.0	-2.5
Medication: Seretide 50 evohaler	2.5	2.8	8.5	0.7	0.8	-2.3	-1.6	0.1	-1.5	-2.9
Arm fat mass (left)	2.5	10.1	45.3	6.7	2.9	1.7	0.5	2.0	-3.1	0.5
Commuting to job workplace: Cycle	2.5	3.1	6.4	-2.0	-1.0	-2.2	-1.4	-2.5	0.5	-1.6
Qualifications: None of the above	2.4	5.1	17.3	-0.2	-1.0	2.0	4.2	2.9	-1.0	2.0
Arm fat mass (right)	2.4	10.0	45.6	6.8	2.9	1.5	0.3	2.0	-3.0	0.3
Supplements: Vitamin C	2.4	2.8	4.6	1.8	1.0	1.4	1.9	2.1	-2.1	0.9
Qualifications: nursing, teaching	2.4	3.7	12.2	0.7	1.2	-1.6	-3.5	-1.5	-0.9	-2.6
Basal cell carcinoma (self-reported)	2.4	2.9	17.4	-0.7	0.3	-0.9	-0.0	0.9	4.2	0.7
Financial difficulties in last 2 years	2.3	3.1	6.4	2.2	2.5	-1.2	0.2	2.1	-1.8	-1.1
Glaucoma (self-reported)	2.3	2.7	6.2	-1.5	-0.6	2.3	2.5	-0.2	0.9	2.1
Smoking status: Previous	2.3	3.4	5.6	-2.4	-1.4	-1.9	-2.1	-2.1	1.5	-1.4
HDL Cholesterol	2.2	3.6	25.5	0.0	5.0	0.0	0.0	0.0	0.0	0.0
Standing height	2.2	22.2	64.6	0.1	-2.5	-2.4	-8.0	-7.1	3.9	-3.7
Comparative body size at age 10	2.2	5.9	15.2	3.9	3.1	0.6	-0.0	3.1	-2.5	-0.4
Alcohol usually taken with meals	2.1	3.4	9.8	-0.1	-0.4	-2.3	-3.1	-1.4	0.4	-2.5
Alcohol intake frequency.	2.1	4.9	15.8	0.3	-0.4	2.5	4.0	1.9	-1.1	2.7
Knee pain experienced in last month	2.1	3.3	11.1	2.1	-0.3	-0.8	0.7	2.1	-3.3	-1.4
Diastolic blood pressure, automated reading	2.1	6.5	18.1	0.8	1.2	2.3	4.3	3.1	-2.5	2.0
Unable to work because of sickness or disability	2.1	2.7	4.1	0.5	1.8	2.0	2.0	1.7	-1.7	1.3
Neuroticism (2016)	2.0	2.9	6.0	-1.7	1.8	-2.2	-1.6	0.1	-1.0	-2.4
Hayfever, allergic rhinitis or eczema	2.0	4.4	11.3	3.3	2.4	-0.0	1.5	3.4	-0.9	0.1
Ever had bowel cancer screening	2.0	2.3	5.7	-1.0	0.1	-1.8	-2.4	-1.1	1.0	-2.1
Allergy or Eczema	1.9	5.1	12.7	3.1	2.4	0.4	2.0	3.6	-1.7	0.3
Medication: Co-codamol	1.9	2.2	8.1	2.0	0.6	0.5	1.2	2.8	-1.2	0.3
Alcohol drinker status: Never	1.9	2.3	7.5	0.5	0.1	1.8	2.7	0.6	-0.7	2.1
Fractured/broken bones in last 5 years	1.9	2.4	5.8	-0.3	1.2	-1.3	-2.4	-1.9	0.3	-2.1
Supplements: Calcium	1.9	2.1	4.8	-2.2	-0.9	-0.1	-1.2	-2.2	1.7	-0.2
Allergy	1.8	4.2	16.2	-2.3	-1.7	0.3	-2.1	-4.0	1.1	0.0
Medication: Paracetamol	1.8	2.8	6.3	2.5	2.3	-1.0	0.4	2.2	-1.4	-0.8
Pain experienced in last month	1.8	3.0	10.7	-1.4	1.0	1.3	-0.7	-1.9	3.3	1.2
Illnesses of mother	1.7	2.1	5.3	-1.6	-2.3	0.6	1.0	-0.6	1.9	1.3
Pulse wave peak to peak time	1.7	2.0	4.9	1.6	1.6	0.9	1.0	2.2	0.1	1.3
Medication for pain relief, constipation, heartburn	1.7	3.0	7.6	-1.9	-2.6	1.1	-0.9	-2.8	0.9	0.8
Medication: Ibuprofen	1.7	2.0	5.1	1.9	2.3	-1.3	-0.3	1.7	0.1	-0.8
Commuting to job workplace: Walk	1.7	1.9	6.5	0.9	2.6	-0.7	0.1	1.9	-1.1	-0.7
Back pain experienced in last month	1.7	2.5	8.5	0.7	-0.6	-2.9	-0.7	1.0	-1.3	-2.3
Age started oral contraceptive pill	1.7	2.1	6.3	-1.6	-1.9	-0.2	-1.3	-2.5	0.7	-0.7
Blood Eosinophil Count	1.6	12.1	30.8	2.4	3.5	1.7	4.7	5.5	-2.9	1.8
Heel T-Score	1.6	13.0	49.4	0.6	0.1	3.4	7.0	2.7	-1.9	4.3
Severe depression (siblings)	1.6	1.7	5.0	2.0	2.2	-0.3	-0.6	1.6	0.3	-0.6
Serious illness, injury or assault to yourself	1.6	1.9	5.5	0.5	-0.4	-1.2	-2.3	-0.7	-0.7	-2.3
Weight	1.6	8.1	42.7	6.5	1.9	0.4	-2.4	0.3	-1.7	-1.1
Breastfed as a baby	1.6	2.0	7.8	-0.1	0.3	-0.4	-2.8	-1.4	1.9	-0.9
Medication: Paracetamol	1.6	2.7	5.1	2.2	1.8	0.2	1.4	2.3	-1.9	0.2
Family relationship satisfaction	1.6	2.0	4.9	-2.1	-0.6	1.8	0.3	-2.2	-0.2	0.8
Other serious medical condition/disability diagnosed by doctor	1.5	2.0	5.4	1.0	2.3	-0.7	-1.3	0.9	-1.3	-1.6
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.4	7.1	1.0	2.0	0.8	0.8	1.8	-2.7	-0.2
Medication: Ibuprofen (e.g. Nurofen)	1.5	1.9	4.7	2.1	2.2	-0.6	0.4	1.9	0.2	-0.1
Mouth/teeth dental problems: Bleeding gums	1.5	1.9	3.5	-0.6	1.1	-1.6	-1.9	-1.4	-0.8	-1.8
Number of children fathered	1.5	1.7	4.2	-0.1	-1.4	-1.2	-2.0	-1.4	1.0	-1.0
Alzheimer’s Disease (in father)	1.4	1.5	6.2	1.2	0.8	-0.3	0.3	1.5	2.5	0.5
Pack years adult smoking proportion	1.4	2.2	4.7	1.4	1.0	1.6	2.2	1.5	-0.2	1.7
Trunk fat-free mass	1.4	7.9	29.0	2.4	-2.1	-1.4	-5.4	-2.5	0.9	-2.6
Trunk predicted mass	1.4	7.9	29.2	2.5	-2.1	-1.4	-5.4	-2.5	0.8	-2.6
Mouth/teeth dental problems: Loose teeth	1.4	1.7	3.1	-1.7	-0.8	-1.7	-1.4	-0.9	0.3	-1.6
Medication: Allopurinol	1.4	1.8	3.7	-1.4	-1.4	-0.8	-1.6	-1.9	-0.4	-1.4
Mouth/teeth dental problems: Mouth ulcers	1.4	2.3	8.2	-2.9	-0.4	-0.8	2.0	0.8	1.1	1.1
Bipolar Disorder or Schizophrenia	1.3	3.3	21.2	1.3	4.6	0.0	0.0	0.0	0.0	0.0
Alzheimer’s Disease (in mother)	1.3	1.5	3.3	-0.9	0.5	-1.8	-1.5	-0.7	1.1	-1.6
Blood Platelet Count	1.3	15.0	57.9	-2.4	1.0	2.3	7.6	4.0	-2.9	3.3
Type 2 Diabetes (T2D) (2018)	1.3	2.3	6.2	-1.8	-0.5	1.4	2.5	1.5	-0.2	1.6
Bilateral oophorectomy (both ovaries removed)	1.3	1.4	5.2	1.6	1.1	0.1	0.8	2.3	0.6	0.5
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	5.5	0.5	1.0	-1.7	-0.9	0.9	-0.9	-2.4
Falls in the last year	1.3	1.8	5.1	1.6	2.3	-0.1	-0.9	1.3	-1.2	-1.1
Medication: Ventolin 100micrograms inhaler	1.3	1.7	6.4	-2.5	-1.6	0.1	0.8	-0.8	1.1	0.5
Chronic bronchitis/emphysema (mother)	1.3	1.6	3.1	1.3	1.8	-0.9	-1.1	1.4	-0.5	-1.4
Neck or shoulder pain in last month	1.3	1.8	4.4	-0.9	0.6	-2.1	-1.0	0.9	-0.9	-2.1
Breast cancer (self-reported)	1.3	1.5	4.2	-0.4	0.9	-0.4	-2.1	-0.5	2.0	-0.9
Medication: Gliclazide	1.3	1.5	7.0	-2.6	-1.4	-0.4	0.2	-1.1	-0.5	-0.3
Irritability	1.3	2.1	5.5	0.3	2.3	-0.5	0.3	1.9	-2.1	-1.0
Ever depressed for a whole week	1.3	1.6	5.1	-0.5	0.6	-1.2	-1.8	-0.6	2.3	-0.9
Schizophrenia (2018)	1.2	2.5	17.7	0.0	4.2	0.0	0.0	0.0	0.0	0.0
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	4.3	0.2	0.8	1.3	2.1	0.6	-0.8	1.5
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	4.5	0.4	1.9	0.5	1.1	2.1	-1.8	-0.1
Heart attack	1.2	1.5	3.7	-0.8	-1.1	-1.4	-1.1	-1.9	-0.6	-1.4
Peak expiratory flow (PEF)	1.2	2.7	5.6	-0.7	0.4	-2.1	-2.4	-1.3	1.5	-2.1
Loud music exposure frequency	1.2	1.3	4.3	1.9	2.1	0.0	-0.2	1.1	0.1	-0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.4	3.5	0.5	0.6	-1.4	-1.4	-1.3	-0.7	-1.9
Number of full sisters	1.2	1.4	4.6	0.4	-0.0	1.4	0.9	0.4	2.1	1.6
Whole body fat-free mass	1.2	6.7	22.8	3.7	-1.0	-0.8	-4.8	-1.8	0.0	-2.2
Medication for cholesterol	1.2	1.8	7.2	-0.5	-0.7	0.9	0.6	-0.7	2.7	1.7
Medication: Aspirin	1.2	1.5	3.7	-0.0	0.8	-1.9	-1.6	-0.6	0.6	-1.8
Whole body water mass	1.2	6.9	24.1	3.6	-1.1	-0.9	-4.9	-2.0	0.1	-2.4
Tinnitus: Yes, now most or all of the time	1.2	1.4	4.2	0.1	0.9	0.8	1.6	2.1	-0.1	1.1
Medication: Lisinopril	1.2	1.5	8.0	-2.8	-0.9	-0.9	1.0	0.2	-0.4	0.1
Average weekly beer plus cider intake	1.2	1.7	3.4	0.8	-1.0	1.8	1.3	0.6	1.1	1.9
Heart attack/myocardial infarction (self-reported)	1.2	1.6	3.6	-0.9	-1.1	-1.4	-1.0	-1.9	-0.7	-1.4
Arm predicted mass (left)	1.2	6.2	19.6	3.7	-0.9	-1.1	-4.4	-1.4	-0.1	-2.4
Reaction Time	1.1	2.0	4.6	-0.7	0.6	2.1	2.1	-0.4	-1.0	1.8
Number of treatments/medications taken	1.1	2.0	3.5	1.0	1.9	-1.3	-0.1	1.7	-1.6	-1.5
Average weekly spirits intake	1.1	1.4	5.6	2.4	0.1	-0.1	0.5	0.9	-1.7	-0.4
Leg fat-free mass (left)	1.1	5.8	23.0	4.8	0.3	0.3	-3.7	-1.3	-0.6	-1.3
Leg predicted mass (left)	1.1	5.8	23.2	4.8	0.3	0.3	-3.6	-1.3	-0.7	-1.3
Had menopause	1.1	1.3	4.7	1.2	0.2	-0.5	-2.2	-1.1	-0.0	-1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.6	8.0	-0.5	1.3	1.5	2.8	1.0	-0.5	2.1
Pain all over the body in last month	1.1	1.1	2.7	1.1	-0.2	0.9	1.6	1.4	-0.4	1.1
Neuroticism score	1.1	2.2	5.8	0.6	1.5	-0.3	0.4	2.4	-2.4	-1.0
Hypothyroidism/myxoedema (self-reported)	1.1	2.1	7.3	0.9	2.7	1.7	-0.6	-0.0	-1.7	0.4
Arm fat-free mass (right)	1.1	5.4	18.4	3.2	-1.0	-1.0	-4.3	-1.3	-0.1	-2.3
Arm predicted mass (right)	1.1	5.4	18.4	3.1	-1.2	-1.1	-4.3	-1.4	0.1	-2.3
Illness, injury, bereavement, stress in last 2 years	1.1	1.4	2.8	-1.6	-1.7	0.6	0.2	-1.6	0.7	0.8
Leg fat-free mass (right)	1.1	5.9	21.4	4.6	0.2	-0.0	-3.9	-1.2	-0.7	-1.7
Long-standing illness, disability or infirmity	1.1	1.6	9.3	-0.1	0.6	0.3	0.8	0.8	-3.0	-0.7
Osteoarthritis (self-reported)	1.1	1.4	4.2	0.4	-2.1	0.4	1.4	1.3	-1.3	0.2
Leg predicted mass (right)	1.1	5.7	21.0	4.6	0.3	0.1	-3.8	-1.2	-0.7	-1.5
Commuting to job workplace: Public transport	1.1	1.3	5.5	1.5	2.3	-0.1	-0.3	0.5	-1.1	-0.4
Basal metabolic rate	1.1	6.3	19.5	4.4	-0.3	-0.5	-4.3	-1.4	-0.4	-2.0
Arm fat-free mass (left)	1.1	5.7	19.2	3.4	-0.8	-1.0	-4.4	-1.5	0.3	-2.3
Ever had prostate specific antigen (PSA) test	1.1	1.3	3.7	0.3	0.5	-1.1	-1.9	-1.1	0.3	-1.5
Hypothyroidism (self reported)	1.0	2.2	5.7	1.6	2.4	2.1	-0.5	-0.1	-1.4	0.7
Vitamin and mineral supplements	1.0	1.4	2.7	-0.4	-0.6	-1.5	-1.6	-1.4	0.7	-1.3
Diabetes (father)	1.0	1.2	2.9	1.1	-0.6	0.3	1.2	1.5	-1.7	0.1
High blood pressure (mother)	1.0	1.4	4.8	1.1	2.2	1.2	0.5	1.2	-0.4	0.8
Had other major operations	1.0	1.3	2.7	1.3	0.9	-0.7	-1.3	-0.3	-1.3	-1.6
Time employed in main current job	1.0	1.2	2.1	0.1	-1.1	1.4	1.3	1.1	-0.5	1.2
Father’s age at death	1.0	1.3	5.3	-1.3	-0.4	0.7	-0.8	-2.3	0.7	0.5
Pulse wave reflection index	1.0	1.2	3.4	-1.8	-0.9	-0.6	-0.3	-1.8	0.1	-0.6
Gout (self-reported)	1.0	1.4	3.1	-0.7	-1.2	-1.1	-1.3	-1.8	-0.6	-1.2
Commuting to job workplace: Car/motor vehicle	1.0	1.2	4.0	0.3	-2.0	1.0	1.2	1.1	-0.6	0.5
Illnesses of father: None of the above (group 1)	1.0	1.2	3.6	-1.1	-0.7	-0.6	-0.7	-1.9	-1.3	-0.9
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.0	2.0	7.6	1.6	0.4	-0.3	1.4	2.8	1.0	0.9
Number of self-reported non-cancer illnesses	1.0	1.7	4.9	0.5	2.2	-0.5	0.3	2.1	-1.2	-0.7
Average weekly champagne plus white wine intake	1.0	1.4	4.8	-0.0	-0.6	-0.9	-1.7	-1.1	2.2	-0.1
Heart disease (siblings)	1.0	1.2	3.9	-0.1	0.6	-0.6	1.3	1.4	-2.0	-0.4
Alzheimer’s Disease (including proxy)	0.9	1.3	3.9	-0.3	0.6	-1.7	-0.7	0.2	2.0	-1.0
Ovarian Cancer	0.9	1.2	3.3	-0.2	-0.6	1.7	1.8	-0.1	-0.3	1.2
Cardiovascular Disease	0.9	2.8	9.2	0.4	3.0	1.5	1.5	2.2	-0.6	0.8
Neuroticism	0.9	2.1	5.7	1.1	2.0	-0.7	0.1	2.4	-1.6	-1.0
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	3.1	-1.8	-1.6	-0.3	0.5	-1.1	0.4	0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.9	1.2	3.2	1.3	1.0	0.1	0.9	1.8	-1.4	0.0
Medication: Levothyroxine sodium	0.9	1.6	6.5	0.7	2.5	0.7	-1.4	-0.2	-1.2	-0.5
Noisy workplace	0.9	1.1	4.3	-1.6	-2.1	-0.3	0.1	-0.2	0.6	-0.8
Ever highly irritable/argumentative for 2 days	0.9	1.1	4.0	0.3	-0.1	1.3	2.0	0.8	0.4	1.2
Number of full brothers	0.9	1.1	3.0	-0.9	-1.7	-1.1	0.2	0.1	1.6	0.2
Suffer from ‘nerves’	0.9	1.4	5.2	-0.6	0.0	-0.5	-0.3	1.3	-2.3	-1.4
Age at last live birth	0.9	1.2	4.4	1.6	0.7	-0.3	-0.7	-0.1	2.1	0.8
Ever taken oral contraceptive pill	0.9	1.1	4.0	-2.0	-0.3	-0.8	-1.0	-0.5	1.1	-0.4
Medication: Bendroflumethiazide	0.9	1.4	8.2	-0.1	0.3	-0.1	-0.1	-0.8	-2.9	-0.7
Medication: Omeprazole (e.g. Zanprol)	0.9	1.0	2.7	-0.0	1.3	0.4	1.7	1.5	-0.3	0.7
Depression (Nagel 2018)	0.8	1.2	4.1	1.4	2.0	-0.2	0.5	1.0	-1.1	-0.1
Schizophrenia (2014)	0.8	1.8	12.5	0.0	3.5	0.0	0.0	0.0	0.0	0.0
Triglycerides	0.8	1.3	8.9	0.0	-3.0	0.0	0.0	0.0	0.0	0.0
Lung FVC	0.8	4.2	9.2	0.4	-0.4	0.9	3.0	3.0	1.7	2.6
Hand grip strength (left)	0.8	2.0	9.4	0.4	-3.1	-1.1	-1.0	-0.6	0.9	-1.0
Medication: Metformin	0.8	1.1	3.9	-2.0	0.8	0.0	1.1	1.3	-0.4	0.4
Current tobacco smoking	0.8	1.3	4.1	-0.6	-0.4	1.2	2.0	0.9	-0.1	1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.8	6.3	0.2	0.7	1.2	2.5	0.3	-1.5	1.4
Tinnitus: Yes, but not now, but have in the past	0.8	0.9	2.8	1.0	0.3	1.0	-0.1	0.5	1.7	1.0
Waist circumference	0.8	2.8	11.5	3.4	0.3	0.8	0.9	1.5	-2.0	0.4
Diabetes (self-reported)	0.8	1.2	7.2	-2.7	-0.7	-0.3	0.7	-0.1	-0.3	0.1
Headache pain in last month	0.8	1.4	5.3	0.4	2.3	0.8	0.6	0.7	-1.6	0.5
Medication: Amlodipine	0.8	1.1	2.3	-1.0	0.2	-1.5	-1.4	-0.4	0.8	-1.1
High blood pressure (siblings)	0.8	1.2	4.5	2.1	0.4	1.0	0.6	1.0	-0.9	0.6
Health satisfaction	0.8	1.0	2.4	-1.5	-1.4	0.6	0.2	-1.5	0.1	0.5
Emphysema/chronic bronchitis	0.8	0.9	2.6	0.2	-0.7	0.4	1.5	1.6	0.0	0.9
Heart disease (mother)	0.8	1.0	3.4	0.5	0.4	-0.3	-1.2	-0.1	-1.8	-1.1
Illnesses of father: Heart disease	0.8	1.1	2.2	-0.8	-1.4	-0.7	-1.4	-0.4	1.5	-0.7
Eye problems/disorders: Cataract	0.8	0.9	3.3	-0.3	-0.1	1.1	0.9	-0.5	-1.8	0.9
Mother’s age at death	0.8	1.0	3.0	0.0	-0.1	-1.7	-1.5	-0.4	0.5	-1.1
Number of operations (self-reported)	0.8	1.2	7.4	-0.1	0.3	-0.1	0.2	-0.5	-2.7	-0.6
Cholesterol lowering medication	0.8	1.1	5.6	-0.4	0.8	-0.4	0.2	0.0	-2.4	-1.1
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	3.3	-0.5	-1.0	0.6	1.8	0.9	-0.5	1.0
Neuroticism (Nagel 2018)	0.7	1.8	5.9	0.8	1.7	-0.1	0.9	2.4	-1.5	-0.1
Bipolar Disorder (2011)	0.7	0.7	5.0	0.0	2.2	0.0	0.0	0.0	0.0	0.0
Relative age of first facial hair	0.7	1.5	2.8	0.2	1.2	0.5	1.7	1.7	-1.6	0.5
Fed-up feelings	0.7	1.3	5.7	0.7	0.5	-0.0	1.1	2.4	-1.2	-0.5
Relative age voice broke	0.7	1.0	2.2	-0.6	-0.4	1.1	1.5	0.7	-1.4	0.7
Mouth/teeth dental problems	0.7	1.1	2.6	0.9	1.2	1.6	0.5	0.9	0.5	1.3
Illnesses of siblings	0.7	0.9	2.6	-1.0	-0.2	0.2	-0.7	-1.5	1.6	0.1
Alcohol intake versus 10 years previously	0.7	1.1	2.5	-0.1	-1.5	0.4	1.4	0.9	-1.6	-0.2
Prospective memory result	0.7	0.8	4.0	0.2	-0.2	0.3	0.8	0.9	-2.0	-0.3
Lung cancer (father)	0.7	0.8	2.4	0.3	-0.8	1.6	0.6	-0.2	0.7	1.4
Birth weight of first child	0.7	1.3	2.8	-0.8	-1.1	-1.3	-1.7	-0.0	1.2	-1.4
Blood clot in the leg (DVT)	0.7	0.9	2.8	-0.4	-1.2	0.4	1.7	0.8	-0.3	0.9
Age at first live birth	0.7	1.2	3.2	1.2	-0.0	-1.2	-1.3	-0.5	1.8	-0.3
Medication: Aspirin	0.7	1.0	2.6	-0.0	0.9	-1.6	-1.0	-0.2	-0.2	-1.5
Illnesses of siblings: Diabetes	0.7	0.8	1.7	-1.3	-1.0	-0.7	0.9	0.5	1.0	0.6
Diabetes diagnosed by doctor	0.7	1.1	4.8	-2.2	-0.6	-0.3	1.2	0.7	-0.6	0.1
Medication: Blood pressure	0.7	1.3	3.0	-0.3	0.8	-1.4	-1.0	-0.7	-1.5	-1.7
Pack years of smoking	0.7	1.0	2.5	0.9	0.6	1.1	1.6	0.9	-0.2	1.2
Depressed Affect (Nagel 2018)	0.6	1.4	6.5	0.6	0.7	-0.4	1.1	2.5	-0.9	-0.0
Irritable Bowel Disease (IBD)	0.6	1.5	2.7	0.7	-0.1	-1.6	-1.6	0.9	1.2	-1.5
Ulcerative Colitis (UC)	0.6	1.1	2.3	0.8	1.3	-1.5	-1.1	0.6	0.6	-0.9
Respiratory disease	0.6	1.4	6.7	0.1	0.8	-0.8	1.0	2.6	-0.5	-0.8
Lung FEV1/FVC ratio	0.6	3.1	11.2	-3.3	-1.4	-0.6	0.8	-0.8	2.4	0.9
Sensitivity / hurt feelings	0.6	1.0	2.1	-1.4	0.1	-1.1	-0.9	-0.5	-0.8	-1.4
Stomach or abdominal pain in last month	0.6	0.7	2.9	0.9	1.7	0.5	0.5	0.6	-0.2	0.7
Hair/balding pattern: Pattern 2	0.6	0.8	2.1	-1.5	-0.8	-0.9	-0.4	-1.1	-0.5	-0.6
Fluid intelligence score	0.6	1.3	4.5	0.3	1.4	-0.8	-2.1	0.1	1.0	-1.0
Mouth/teeth dental problems: Dentures	0.6	1.0	2.4	0.6	-1.2	-0.7	-0.3	-0.0	-1.5	-1.4
Medication: Cholesterol lowering	0.6	0.9	2.0	-1.1	0.5	-0.8	-0.6	-0.4	-1.4	-1.1
Birth weight	0.6	1.4	4.0	-0.5	-1.8	-0.2	-1.2	-2.0	0.8	-0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	4.6	0.4	0.3	0.2	0.8	0.1	-2.1	0.1
Angina (self-reported)	0.6	0.8	2.5	-0.9	1.6	-0.6	-0.8	-0.5	0.1	-1.1
Friendships satisfaction	0.6	0.7	2.3	-1.0	1.5	0.2	-0.8	-0.9	-0.1	-0.7
Asthma (self-reported)	0.6	1.2	3.4	-1.1	0.8	-1.2	0.5	1.9	0.3	-1.1
Smoking status: Current	0.6	1.0	3.2	-0.7	-0.0	0.8	1.8	0.8	0.1	1.3
Miserableness	0.6	1.1	2.1	0.1	1.1	-0.9	-0.1	1.3	-1.3	-1.4
Wears glasses or contact lenses	0.6	0.7	2.3	1.2	-0.2	-0.1	-1.5	-0.5	0.3	-0.9
Medication: Atorvastatin	0.6	0.7	2.4	-1.6	0.9	-0.7	-0.7	-0.5	0.4	-0.7
Risk taking	0.6	0.8	1.7	0.4	1.3	-1.1	-0.9	-0.4	-0.4	-1.3
Worry (Nagel 2018)	0.5	1.0	3.1	0.7	1.4	0.0	0.5	1.8	-1.0	-0.2
Coronary Artery Disease (CAD)	0.5	0.6	4.0	0.0	-2.0	0.0	0.0	0.0	0.0	0.0
Blood White Count	0.5	3.4	11.4	-0.8	0.9	-1.2	-2.1	1.0	-2.1	-3.4
Frequency of depressed mood in last 2 weeks	0.5	0.8	3.1	0.4	1.8	-0.4	0.5	1.2	-0.2	-0.3
Hearing difficulty/problems: Yes	0.5	0.8	2.2	-0.4	-1.1	0.1	0.9	0.6	1.5	0.9
Angina	0.5	0.6	2.4	-0.7	1.6	-0.5	-0.6	-0.3	0.2	-0.9
Medication for hormone replacement therapy	0.5	0.5	1.5	0.8	0.2	0.7	0.5	1.2	-0.7	0.7
Diabetes (mother)	0.5	0.6	1.7	0.8	1.1	0.2	0.7	1.3	0.0	0.5
Impedance of leg (right)	0.5	2.5	7.5	-2.7	0.5	0.2	2.4	-0.6	1.4	1.4
Supplements: Glucosamine	0.5	0.7	1.9	0.2	-0.4	-0.1	1.4	1.1	-1.1	0.3
Impedance of leg (left)	0.5	2.6	7.9	-2.4	1.1	0.1	2.8	0.3	1.1	1.3
Medication: Simvastatin	0.5	0.7	2.3	-0.7	0.2	-0.6	-0.2	-0.7	-1.5	-1.1
Impedance of arm (right)	0.5	2.2	5.7	-0.7	2.4	1.4	1.4	-1.7	0.6	1.5
Hair/balding pattern: Pattern 3	0.5	0.7	1.3	1.1	-0.1	1.0	0.3	1.1	-1.0	-0.1
Number of live births	0.5	0.7	1.2	-1.0	1.0	0.7	0.3	-1.0	0.5	1.1
Asthma	0.5	0.9	2.2	-1.3	0.5	-0.9	0.5	1.5	0.7	-0.8
Impedance of arm (left)	0.5	2.2	6.3	-0.6	2.5	1.3	1.6	-1.4	0.6	1.6
Exposure to tobacco smoke at home	0.5	0.6	1.1	0.9	-0.7	-1.1	-0.3	0.7	0.7	-0.7
Medication: Omeprazole	0.5	0.6	1.7	-0.2	1.0	0.4	0.9	0.7	-1.3	0.2
Mean time to correctly identify matches	0.5	0.9	1.8	-0.9	0.5	1.3	1.1	-1.0	-0.7	1.0
Overall health rating	0.5	1.2	5.6	0.5	-0.2	0.2	0.5	1.3	-2.4	-0.5
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.1	0.5	-0.3	0.9	1.1	0.8	-0.7	0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.6	-1.3	-0.9	0.3	0.4	-0.6	1.0	0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.8	1.0	1.3	-0.8	-0.4	0.6	0.1	-0.4
Osteoporosis (self-reported)	0.5	0.6	2.2	0.4	1.2	-0.1	0.0	0.5	-1.5	-0.4
Guilty feelings	0.5	0.7	1.6	0.8	1.3	-0.7	-0.6	1.1	-0.7	-0.7
Financial situation satisfaction	0.5	0.6	1.3	-1.1	0.5	-1.1	0.9	0.6	0.1	-0.3
Myopia	0.5	0.7	2.8	-0.3	0.2	1.7	0.4	-0.7	0.5	1.2
Impedance of whole body	0.5	2.5	5.9	-1.5	2.1	0.8	2.4	-0.5	1.1	1.7
Bipolar Disorder (2018)	0.4	0.6	4.5	0.0	2.1	0.0	0.0	0.0	0.0	0.0
Intelligence (Savage-Jansen 2018)	0.4	1.1	3.1	0.9	1.6	-0.2	-1.8	0.3	-0.9	-0.9
Crohns Disease (2012)	0.4	0.6	4.2	0.0	-2.0	0.0	0.0	0.0	0.0	0.0
Primary Biliary Cirrhosis	0.4	0.6	2.6	-1.6	1.1	0.0	0.0	0.0	0.0	0.0
Systolic Blood Pressure	0.4	1.8	4.5	-1.0	-2.1	0.3	1.2	0.9	1.9	0.8
Chronotype (morning person)	0.4	1.0	2.7	1.6	1.0	1.7	-0.5	0.2	-0.2	0.1
Systolic blood pressure, automated reading	0.4	1.2	3.9	0.7	-2.0	0.3	1.3	1.0	0.9	0.8
Supplements: Zinc	0.4	0.5	1.0	-0.3	-0.3	1.0	0.6	-1.0	0.3	0.9
Age when periods started (menarche)	0.4	0.9	3.7	-1.1	0.2	-0.0	0.6	-0.2	1.9	0.8
Qualifications: CSEs or equivalent	0.4	0.5	1.4	-0.6	-1.2	0.1	0.8	-0.4	0.5	0.7
Chronic bronchitis/emphysema (father)	0.4	0.5	2.3	-0.4	-0.0	-0.2	0.4	1.5	0.9	0.3
Number of incorrect matches in round	0.4	0.7	1.3	-1.0	-1.1	0.4	0.7	-0.3	1.0	1.0
Nervous feelings	0.4	0.7	2.4	0.1	1.6	-0.4	-0.5	0.5	-0.7	-1.1
Medication: Ramipril	0.4	0.5	1.8	-1.3	0.4	-0.6	0.1	-0.2	1.0	-0.1
Tense / ‘highly strung’	0.4	0.7	2.1	-0.1	0.8	-0.8	0.6	1.5	-0.9	-0.6
Worry too long after embarrassment	0.4	0.7	3.5	0.2	0.5	0.1	-0.2	0.7	-1.9	-0.6
Shortness of breath walking on level ground	0.4	0.5	1.7	1.3	0.5	-0.3	-0.3	0.8	0.2	-0.8
Eye problems/disorders: None of the above	0.4	0.4	1.0	0.3	-0.7	-0.4	-1.0	-0.2	1.0	-0.5
Had major operations	0.4	0.4	1.7	0.1	-0.0	0.7	-0.6	-1.3	-0.7	0.2
Leg pain on walking	0.4	0.4	1.5	-0.3	-0.6	-0.2	0.1	0.6	-1.2	-0.9
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.9	0.4	0.7	-0.6	0.5	1.4	0.3	-0.0
Mood swings	0.4	0.6	1.5	0.2	0.6	-0.7	0.1	1.2	-1.0	-1.0
Loneliness, isolation	0.4	0.6	2.5	0.7	0.7	-0.5	0.5	1.6	-0.4	0.1
Hearing aid user	0.4	0.4	1.0	-1.0	-0.1	-0.8	-0.3	0.3	0.9	-0.4
Eye problems/disorders: Glaucoma	0.4	0.5	1.5	-1.2	-0.5	0.1	0.3	-0.7	1.1	0.1
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.2	0.1	-0.4	0.6	1.1	-0.3	0.5	1.1
High cholesterol (Self-reported)	0.4	0.6	2.2	-1.5	0.3	-0.2	0.9	0.5	-0.9	-0.2
Crohns Disease (2017)	0.3	0.7	2.0	0.4	-1.4	-0.6	-0.9	0.5	0.9	-0.8
Verbal and Numeric Reasoning (VNR)	0.3	0.8	1.8	-0.9	0.8	-0.7	-1.4	0.1	1.1	-0.6
Body Mass Index (BMI) (2010)	0.3	0.5	3.3	0.0	1.8	0.0	0.0	0.0	0.0	0.0
HbA1C	0.3	0.3	1.5	1.2	-0.9	0.0	0.0	0.0	0.0	0.0
Lupus	0.3	0.5	1.0	-0.6	0.4	-0.6	-0.6	-0.7	1.0	-0.6
Ever had hysterectomy (womb removed)	0.3	0.3	0.9	-0.7	0.3	-0.2	0.8	0.9	-0.2	-0.2
Hand grip strength (right)	0.3	0.8	3.6	1.0	-1.9	-0.3	-0.6	0.4	-0.0	-0.4
Townsend deprivation index at recruitment	0.3	0.4	1.1	0.9	0.6	0.2	1.1	0.2	-0.5	0.6
Taking other prescription medications	0.3	0.5	1.5	-0.5	1.2	-0.1	0.0	0.7	-0.9	-0.8
Hearing difficulty/problems with background noise	0.3	0.5	1.5	-0.5	0.5	-0.6	-1.2	-0.1	0.8	-0.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	1.7	-0.3	0.2	0.2	-0.3	-0.8	1.3	0.3
Worrier / anxious feelings	0.3	0.5	1.6	0.3	0.0	0.0	0.5	1.2	-1.3	-0.1
Happiness	0.3	0.4	1.4	-0.4	1.2	0.6	-0.2	-0.6	0.4	0.4
Medication: Lansoprazole	0.3	0.4	1.1	-0.7	-0.7	0.5	1.0	0.3	-0.2	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.1	3.2	1.3	0.9	-0.4	-0.2	1.0	1.8	0.5
Length of working week for main job	0.3	0.3	0.7	-0.0	-0.4	-0.8	0.6	0.6	-0.7	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.2	-0.5	0.9	-0.4	0.3	0.8	-1.1	-0.6
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	0.8	0.5	-0.8	0.0	-0.9	-0.8	0.8	-0.3
Forced vital capacity (FVC), Best measure	0.3	1.1	4.1	1.3	0.7	-0.2	-0.5	0.7	2.0	0.7
Exposure to tobacco smoke outside home	0.3	0.3	1.0	0.8	1.0	-0.3	0.5	0.7	-0.0	0.1
Wheeze or whistling in the chest in last year	0.3	0.5	1.2	-1.0	0.7	0.1	0.5	1.1	-0.4	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.8	0.4	0.3	-0.8	-0.5	-0.2	0.9	-0.4
Migraine (self-reported)	0.3	0.4	1.2	0.3	1.0	0.0	0.5	1.1	-0.4	0.2
Pulse rate, automated reading	0.3	1.1	3.3	0.3	0.3	-0.2	-0.0	1.6	-1.8	-1.1
Hypertension (Self-reported)	0.3	0.9	2.1	0.2	1.5	0.8	1.0	1.2	-0.9	0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	2.2	0.3	-0.5	0.3	-1.1	-1.5	0.9	0.1
Alcohol drinker status: Previous	0.3	0.4	0.9	0.9	0.5	-0.4	-0.3	0.9	0.4	-0.6
Major Depression (MDD)	0.2	0.2	1.2	-1.1	-0.4	0.0	0.0	0.0	0.0	0.0
Blood Red Count	0.2	2.1	9.0	-0.7	-3.0	0.5	1.2	0.6	-1.7	-0.1
Smoking Status	0.2	0.5	1.7	-1.3	-0.8	0.1	0.9	0.0	-0.0	0.6
Hair Pigment	0.2	5.4	19.6	0.5	-0.5	1.7	4.4	2.3	-2.6	1.5
Average weekly fortified wine intake	0.2	0.2	1.0	1.0	0.0	-0.2	0.2	0.5	0.2	0.5
High blood pressure	0.2	0.7	1.4	0.5	1.1	0.7	0.8	1.2	-0.9	0.1
Multivitamins +/- minerals	0.2	0.3	0.9	-1.0	-0.6	0.1	0.8	-0.0	-0.0	0.6
Medication: Atenolol	0.2	0.3	1.3	0.3	0.2	0.1	-0.5	-0.1	1.1	-0.2
Forced vital capacity (FVC)	0.2	0.8	1.9	1.4	0.3	-1.0	-1.2	0.0	1.1	-0.4
Forced expiratory volume in 1-second (FEV1)	0.2	0.6	1.7	0.9	0.4	-1.0	-0.7	0.4	1.3	-0.1
Pulse rate	0.2	0.3	1.2	1.1	-0.3	0.2	0.1	0.5	-0.5	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.1	0.8	1.0	-0.1	-0.3	0.1	0.2	-0.0
Depression (self-reported)	0.2	0.2	0.8	-0.4	0.6	-0.4	0.5	0.9	-0.1	-0.2
Hair/balding pattern: Pattern 4	0.2	0.4	1.1	0.8	0.6	-0.3	-0.4	-0.1	1.1	0.4
Medication: Blood pressure	0.2	0.4	1.3	0.5	0.7	-0.2	0.8	1.2	0.0	0.3
Vascular/heart problems diagnosed by doctor	0.2	0.5	1.1	-0.5	-0.8	-0.4	-0.7	-1.1	0.9	0.2
Tanning	0.1	1.0	3.5	-0.1	0.5	-1.0	-1.9	-0.1	1.2	-0.8
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.9	0.2	-0.9	-0.2	-0.5	-0.0	-0.0	-0.4
Chest pain or discomfort	0.1	0.2	0.9	-0.9	0.3	0.1	-0.4	-0.2	0.2	-0.4
Mineral and other dietary supplements	0.1	0.1	0.4	0.1	0.5	-0.1	-0.6	0.4	0.3	-0.2
Schizophrenia vs Biploar Disorder	0.0	0.0	0.1	0.0	0.3	0.0	0.0	0.0	0.0	0.0
Breast Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Mean Putamen Volume	0.0	0.0	0.2	0.0	-0.5	0.0	0.0	0.0	0.0	0.0
Fasting Glucose	0.0	0.0	0.1	0.1	0.3	0.0	0.0	0.0	0.0	0.0
LDL Cholesterol	0.0	0.0	0.1	0.0	0.3	0.0	0.0	0.0	0.0	0.0
Rheumatoid Arthritis	0.0	0.0	0.2	-0.3	0.4	0.0	0.0	0.0	0.0	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.0	0.0	-0.1	0.0	0.0	0.0	0.0	0.0
Ulcerative Colitis	0.0	0.0	0.0	0.0	0.2	0.0	0.0	0.0	0.0	0.0

Hub : Genes

SNRNP35

Models

Trait associations