Best TWAS P=8.52e-10 · Best GWAS P=1.7e-07 conditioned to 0.0335
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Mucosa | PSRC1 | 0.18 | 0.14 | lasso | 3 | 0.14 | 2.4e-09 | 5.1 | 5.2 | 2.0e-07 | 0.95 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Liver | SYPL2 | 0.34 | 0.27 | lasso | 5 | 0.30 | 4.6e-09 | 4.5 | 5.5 | 4.7e-08 | 0.39 | 0.08 | 0.90 | FALSE |
| 3 | GTEx | Liver | ATXN7L2 | 0.39 | 0.04 | lasso | 12 | 0.21 | 1.3e-06 | 4.9 | 6.0 | 1.6e-09 | 0.69 | 0.05 | 0.83 | FALSE |
| 4 | GTEx | Muscle Skeletal | CELSR2 | 0.41 | 0.31 | lasso | 4 | 0.30 | 2.4e-30 | 5.1 | 5.1 | 3.1e-07 | 0.97 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Whole Blood | PSRC1 | 0.14 | 0.04 | lasso | 3 | 0.03 | 6.9e-04 | 5.2 | 5.2 | 2.5e-07 | 0.97 | 0.01 | 0.98 | FALSE |
| 6 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | MYBPHL | 0.09 | 0.07 | blup | 46 | 0.06 | 5.7e-04 | 3.1 | 6.1 | 8.5e-10 | 0.57 | 0.02 | 0.53 | TRUE |
| 7 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SORT1 | 0.04 | 0.01 | blup | 60 | 0.03 | 4.4e-03 | 5.1 | 5.8 | 5.6e-09 | 0.65 | 0.01 | 0.61 | FALSE |