[Hub]/) : Traits : Trunk fat-free mass :

chr4:305,291-2,437,290

Best TWAS P=7.49e-19 · Best GWAS P=1.72e-16 conditioned to 0.00229

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex CRIPAK 0.31 0.15 enet 34 0.26 1.2e-31 -5.1 -6.9 5.3e-12 0.04 1.00 0.00 FALSE
2 GTEx Adipose Subcutaneous CRIPAK 0.42 0.11 enet 42 0.34 9.0e-29 -5.2 -6.4 1.7e-10 0.04 1.00 0.00 FALSE
3 GTEx Adipose Visceral Omentum UVSSA 0.46 0.05 lasso 11 0.24 1.1e-12 -6.0 -6.2 5.4e-10 0.01 0.85 0.04 FALSE
4 GTEx Adipose Visceral Omentum CRIPAK 0.47 0.24 lasso 12 0.31 1.3e-16 -5.0 -6.8 8.9e-12 0.02 1.00 0.00 FALSE
5 GTEx Artery Aorta UVSSA 0.33 0.06 enet 30 0.28 7.2e-16 -6.0 -6.4 1.8e-10 0.01 0.36 0.62 FALSE
6 GTEx Artery Aorta CRIPAK 0.31 0.20 enet 34 0.30 2.8e-17 -5.0 -6.3 3.6e-10 0.01 1.00 0.00 FALSE
7 GTEx Artery Tibial CRIPAK 0.42 0.09 enet 50 0.34 1.3e-27 2.1 -5.8 9.2e-09 0.02 1.00 0.00 FALSE
8 GTEx Brain Caudate basal ganglia CRIPAK 0.27 0.00 lasso 2 0.02 9.3e-02 -6.0 -6.6 5.3e-11 0.01 0.06 0.06 FALSE
9 GTEx Brain Cerebellum CRIPAK 0.37 0.09 enet 24 0.31 8.8e-10 -5.2 -6.7 1.7e-11 -0.01 0.40 0.06 FALSE
10 GTEx Brain Cortex TACC3 0.26 0.13 lasso 4 0.17 1.7e-05 -7.3 6.6 4.3e-11 0.52 0.24 0.30 FALSE
11 GTEx Brain Cortex CRIPAK 0.34 0.10 lasso 6 0.18 9.5e-06 -5.0 -7.7 1.5e-14 0.03 0.19 0.10 FALSE
12 GTEx Brain Hippocampus CRIPAK 0.48 0.22 lasso 4 0.23 4.0e-06 -5.4 -7.9 3.3e-15 0.00 0.18 0.14 FALSE
13 GTEx Brain Hypothalamus CRIPAK 0.22 0.00 lasso 5 0.01 2.1e-01 -6.0 -6.7 1.9e-11 0.02 0.06 0.08 FALSE
14 GTEx Brain Nucleus accumbens basal ganglia UVSSA 0.24 0.00 enet 33 0.04 2.8e-02 0.8 -5.9 4.6e-09 -0.10 0.07 0.05 FALSE
15 GTEx Brain Nucleus accumbens basal ganglia CRIPAK 0.34 0.13 lasso 6 0.25 2.7e-07 -5.0 -6.7 2.5e-11 0.05 0.20 0.05 FALSE
16 GTEx Brain Putamen basal ganglia CRIPAK 0.30 0.00 enet 25 0.10 1.9e-03 -4.5 -6.7 2.1e-11 0.11 0.06 0.10 FALSE
17 GTEx Breast Mammary Tissue CRIPAK 0.42 0.12 enet 35 0.39 5.2e-21 -5.0 -6.4 1.6e-10 0.02 1.00 0.00 FALSE
18 GTEx Breast Mammary Tissue (Female) CRIPAK 0.32 0.17 enet 29 0.26 2.7e-08 -5.2 -7.6 4.1e-14 0.01 0.53 0.03 FALSE
19 GTEx Cells EBV-transformed lymphocytes CRIPAK 0.49 0.27 lasso 8 0.35 2.9e-12 -5.0 -6.6 5.5e-11 0.05 0.84 0.01 FALSE
20 GTEx Cells Transformed fibroblasts CRIPAK 0.35 0.06 enet 33 0.22 3.0e-16 -5.4 -5.2 1.9e-07 0.09 1.00 0.00 FALSE
21 GTEx Colon Sigmoid CRIPAK 0.40 0.21 lasso 7 0.30 4.7e-11 -6.0 -6.2 6.0e-10 0.06 0.72 0.01 FALSE
22 GTEx Colon Transverse TMEM129 0.23 0.05 lasso 4 0.03 1.8e-02 -7.3 7.3 3.4e-13 0.51 0.09 0.10 FALSE
23 GTEx Colon Transverse CRIPAK 0.33 0.10 enet 22 0.24 5.8e-12 -5.4 -6.5 6.8e-11 0.03 0.97 0.00 FALSE
24 GTEx Colon Transverse RP11-20I20.4 0.17 0.05 lasso 3 0.05 2.3e-03 -6.0 -6.5 8.7e-11 0.01 0.43 0.03 FALSE
25 GTEx Esophagus Gastroesophageal Junction UVSSA 0.30 0.00 enet 23 0.08 1.1e-03 -5.0 -6.0 2.7e-09 0.09 0.28 0.04 FALSE
26 GTEx Esophagus Gastroesophageal Junction CRIPAK 0.33 0.20 lasso 5 0.30 1.4e-11 -5.0 -6.4 2.0e-10 0.02 0.99 0.00 FALSE
27 GTEx Esophagus Mucosa CRIPAK 0.49 0.14 enet 28 0.40 6.8e-29 -5.0 -6.4 1.5e-10 0.00 0.99 0.01 FALSE
28 GTEx Esophagus Muscularis UVSSA 0.35 0.03 enet 33 0.16 3.5e-10 -5.0 -5.6 2.5e-08 0.03 0.93 0.01 FALSE
29 GTEx Esophagus Muscularis CRIPAK 0.38 0.14 enet 34 0.30 2.6e-18 -5.0 -6.3 3.7e-10 0.05 1.00 0.00 FALSE
30 GTEx Esophagus Muscularis RP11-20I20.4 0.19 0.09 lasso 3 0.10 1.9e-06 3.7 -5.3 1.5e-07 0.02 0.78 0.01 FALSE
31 GTEx Heart Atrial Appendage CRIPAK 0.31 0.26 enet 23 0.33 2.1e-15 -5.0 -6.6 5.0e-11 0.03 1.00 0.00 FALSE
32 GTEx Heart Left Ventricle CRIPAK 0.19 0.05 enet 24 0.21 3.4e-11 -5.0 -5.3 1.4e-07 0.10 0.65 0.02 FALSE
33 GTEx Lung CRIPAK 0.61 0.22 enet 46 0.41 1.1e-33 -5.0 -7.9 2.2e-15 0.02 1.00 0.00 FALSE
34 GTEx Lung RP11-20I20.4 0.07 0.00 lasso 3 0.01 6.0e-02 -6.0 -6.8 1.0e-11 0.03 0.14 0.03 FALSE
35 GTEx Muscle Skeletal FGFRL1 0.14 0.08 lasso 4 0.06 3.7e-06 -7.8 7.3 3.5e-13 0.01 0.00 1.00 TRUE
36 GTEx Muscle Skeletal CRIPAK 0.25 0.11 enet 32 0.18 7.6e-18 -5.0 -6.8 8.8e-12 0.03 1.00 0.00 FALSE
37 GTEx Muscle Skeletal AC016773.1 0.12 0.01 lasso 7 0.02 2.5e-03 -7.3 5.7 1.1e-08 0.27 0.68 0.17 FALSE
38 GTEx Nerve Tibial TMEM129 0.31 0.24 enet 13 0.28 5.0e-20 -3.9 5.5 4.7e-08 0.38 1.00 0.00 FALSE
39 GTEx Nerve Tibial CRIPAK 0.50 0.11 enet 76 0.38 1.1e-28 -5.4 -7.7 1.2e-14 -0.08 1.00 0.00 FALSE
40 GTEx Nerve Tibial CTBP1-AS2 0.18 0.03 lasso 5 0.03 3.2e-03 -4.9 -5.3 1.3e-07 0.00 0.61 0.02 FALSE
41 GTEx Ovary UVSSA 0.33 0.10 enet 12 0.32 1.5e-08 -6.0 -6.0 2.1e-09 0.02 0.11 0.06 FALSE
42 GTEx Ovary CRIPAK 0.43 0.27 enet 19 0.32 9.0e-09 -5.0 -7.0 3.4e-12 0.03 0.46 0.06 FALSE
43 GTEx Pancreas TMEM129 0.20 0.19 lasso 3 0.14 1.5e-06 -7.3 7.0 3.5e-12 0.58 0.60 0.34 FALSE
44 GTEx Pancreas CRIPAK 0.34 0.13 lasso 6 0.27 1.0e-11 -5.4 -7.2 4.6e-13 0.01 0.84 0.01 FALSE
45 GTEx Skin Not Sun Exposed Suprapubic CRIPAK 0.39 0.14 lasso 13 0.34 1.5e-19 -5.0 -5.8 4.9e-09 0.01 0.92 0.06 FALSE
46 GTEx Skin Sun Exposed Lower leg TMEM129 0.22 0.16 lasso 5 0.17 5.5e-14 -4.0 5.2 2.7e-07 0.35 1.00 0.00 FALSE
47 GTEx Skin Sun Exposed Lower leg CRIPAK 0.36 0.09 enet 40 0.35 8.7e-30 -5.2 -5.9 3.5e-09 0.03 1.00 0.00 FALSE
48 GTEx Spleen AC016773.1 0.42 0.21 lasso 7 0.16 8.6e-05 -7.4 5.8 7.4e-09 0.50 0.11 0.17 FALSE
49 GTEx Stomach CRIPAK 0.43 0.22 enet 46 0.35 1.4e-17 -5.0 -5.3 9.0e-08 0.06 1.00 0.00 FALSE
50 GTEx Thyroid FGFRL1 0.39 0.05 enet 47 0.14 6.9e-11 3.1 5.2 2.0e-07 0.04 0.98 0.00 FALSE
51 GTEx Thyroid TMEM129 0.44 0.31 lasso 7 0.34 1.2e-26 -4.0 5.9 4.0e-09 0.46 1.00 0.00 FALSE
52 GTEx Thyroid CRIPAK 0.51 0.14 enet 44 0.34 6.1e-27 1.8 -5.2 2.6e-07 0.04 1.00 0.00 FALSE
53 GTEx Thyroid AC016773.1 0.11 0.07 enet 7 0.06 3.9e-05 -7.4 6.8 7.8e-12 0.52 0.51 0.27 FALSE
54 GTEx Uterus CRIPAK 0.52 0.34 lasso 3 0.33 1.7e-07 -6.0 -6.4 2.1e-10 0.01 0.23 0.06 FALSE
55 GTEx Whole Blood TACC3 0.11 0.05 enet 7 0.06 2.8e-06 -4.8 6.8 1.3e-11 0.59 0.80 0.17 FALSE
56 GTEx Whole Blood CRIPAK 0.38 0.17 lasso 9 0.28 3.4e-26 -5.4 -7.1 1.6e-12 0.02 1.00 0.00 FALSE
57 GTEx Whole Blood AC016773.1 0.27 0.21 enet 8 0.22 1.2e-19 -7.3 7.0 3.5e-12 0.53 0.64 0.36 FALSE
58 METSIM Adipose CRIPAK 0.28 0.16 bslmm 335 0.25 2.7e-37 -4.9 -7.8 4.7e-15 -0.01 1.00 0.00 FALSE
59 METSIM Adipose SPON2 0.06 0.06 lasso 8 0.05 2.2e-08 -5.0 -5.2 1.9e-07 0.02 1.00 0.00 FALSE
60 METSIM Adipose TMEM129 0.11 0.09 lasso 8 0.09 3.3e-13 -7.3 6.9 5.5e-12 0.57 0.65 0.35 FALSE
61 METSIM Adipose UVSSA 0.26 0.04 bslmm 366 0.12 9.0e-18 1.8 -6.8 1.4e-11 0.02 0.98 0.02 FALSE
62 NTR Blood CRIPAK 0.13 0.09 enet 31 0.15 1.5e-46 -4.8 -8.9 7.5e-19 0.00 1.00 0.00 TRUE
63 NTR Blood KIAA1530 0.19 0.04 blup 345 0.10 9.1e-32 -6.0 -8.0 9.4e-16 0.08 1.00 0.00 FALSE
64 NTR Blood SLBP 0.04 0.02 lasso 5 0.02 2.8e-08 -7.4 8.1 8.2e-16 0.82 0.04 0.96 FALSE
65 NTR Blood TACC3 0.05 0.03 lasso 9 0.04 2.7e-13 -7.3 8.5 1.6e-17 0.71 0.40 0.60 TRUE
66 ROSMAP Brain Pre-frontal Cortex UVSSA 0.31 0.05 blup 350 0.23 7.1e-29 1.8 -5.9 4.2e-09 -0.05 0.75 0.25 FALSE
67 ROSMAP Brain Pre-frontal Cortex CRIPAK 0.31 0.23 lasso 12 0.40 6.4e-55 -4.9 -6.2 4.5e-10 0.01 1.00 0.00 FALSE
68 ROSMAP Brain Pre-frontal Cortex AC016773.1 0.12 0.06 lasso 3 0.10 3.0e-12 -7.4 6.7 2.8e-11 0.52 0.76 0.24 FALSE
69 YFS Blood CRIPAK 0.35 0.27 bslmm 301 0.33 6.0e-112 -5.4 -7.4 1.4e-13 -0.03 1.00 0.00 FALSE
70 YFS Blood SLBP 0.10 0.12 lasso 3 0.12 1.2e-35 -7.3 7.3 2.7e-13 0.60 0.64 0.36 FALSE
71 YFS Blood TACC3 0.22 0.24 lasso 11 0.27 1.4e-87 -7.3 5.7 1.1e-08 0.34 0.65 0.35 FALSE
72 The Cancer Genome Atlas Bladder Urothelial Carcinoma CRIPAK 0.11 0.07 lasso 4 0.05 2.0e-05 -5.4 -5.8 9.2e-09 0.00 0.00 1.00 FALSE
73 The Cancer Genome Atlas Breast Invasive Carcinoma CRIPAK 0.22 0.11 blup 28 0.14 5.6e-28 -5.4 -7.0 2.1e-12 0.01 0.00 1.00 FALSE
74 The Cancer Genome Atlas Breast Invasive Carcinoma KIAA1530 0.13 0.01 blup 48 0.03 4.9e-07 -5.2 -6.3 2.4e-10 -0.05 0.00 1.00 FALSE
75 The Cancer Genome Atlas Colon Adenocarcinoma CRIPAK 0.38 0.16 blup 28 0.21 2.8e-12 -5.4 -6.2 4.2e-10 0.01 0.00 1.00 FALSE
76 The Cancer Genome Atlas Esophageal Carcinoma CRIPAK 0.39 0.15 blup 28 0.15 1.8e-05 -5.4 -5.1 3.0e-07 -0.06 0.00 0.98 FALSE
77 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma CRIPAK 0.28 0.16 blup 28 0.19 3.2e-21 -5.4 -6.7 2.9e-11 0.03 0.00 1.00 FALSE
78 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma CRIPAK 0.21 0.10 enet 9 0.15 1.3e-16 -5.4 -6.2 6.1e-10 0.00 0.00 1.00 FALSE
79 The Cancer Genome Atlas Brain Lower Grade Glioma CRIPAK 0.31 0.11 enet 10 0.18 1.5e-19 -5.4 -6.4 1.5e-10 -0.03 0.00 1.00 FALSE
80 The Cancer Genome Atlas Liver Hepatocellular Carcinoma CRIPAK 0.13 0.06 blup 29 0.08 1.2e-04 -5.4 -5.8 7.6e-09 0.01 0.00 0.98 FALSE
81 The Cancer Genome Atlas Lung Adenocarcinoma CRIPAK 0.09 0.07 lasso 1 0.06 1.5e-07 -5.4 -5.4 8.4e-08 -0.01 0.00 1.00 FALSE
82 The Cancer Genome Atlas Lung Squamous Cell Carcinoma CRIPAK 0.14 0.05 lasso 4 0.07 6.1e-08 -5.4 -5.7 1.0e-08 0.01 0.00 1.00 FALSE
83 The Cancer Genome Atlas Lung Squamous Cell Carcinoma KIAA1530 0.12 0.02 blup 47 0.03 4.2e-04 -5.1 -5.4 6.4e-08 -0.05 0.00 0.97 FALSE
84 The Cancer Genome Atlas Lung Squamous Cell Carcinoma TMEM129 0.05 0.03 lasso 4 0.02 8.5e-04 4.6 -5.2 2.3e-07 -0.69 0.12 0.49 FALSE
85 The Cancer Genome Atlas Pancreatic Adenocarcinoma CRIPAK 0.34 0.30 lasso 3 0.27 7.5e-12 -5.4 -5.3 1.2e-07 0.00 0.00 1.00 FALSE
86 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma CRIPAK 0.41 0.10 lasso 4 0.08 5.2e-04 -5.4 -5.9 3.4e-09 0.02 0.00 0.98 FALSE
87 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma TACC3 0.09 0.08 enet 7 0.11 2.7e-05 -7.3 6.7 2.8e-11 0.52 0.13 0.23 FALSE
88 The Cancer Genome Atlas Prostate Adenocarcinoma CRIPAK 0.27 0.17 enet 4 0.18 2.7e-18 -5.4 -5.7 1.5e-08 0.00 0.00 1.00 FALSE
89 The Cancer Genome Atlas Prostate Adenocarcinoma TMEM129 0.12 0.01 blup 47 0.05 2.5e-06 -7.3 5.2 2.3e-07 0.18 0.12 0.16 FALSE
90 The Cancer Genome Atlas Rectum Adenocarcinoma CRIPAK 0.37 0.07 lasso 2 0.12 1.2e-03 -5.4 -6.2 7.6e-10 0.03 0.00 0.83 FALSE
91 The Cancer Genome Atlas Soft Tissue Sarcoma CRIPAK 0.20 0.10 lasso 5 0.15 2.2e-09 -5.0 -5.8 8.6e-09 0.07 0.01 0.98 FALSE
92 The Cancer Genome Atlas Soft Tissue Sarcoma TMEM129 0.09 0.04 lasso 2 0.03 3.8e-03 -4.8 -5.1 3.1e-07 -0.51 0.02 0.30 FALSE
93 The Cancer Genome Atlas Skin Cutaneous Melanoma CRIPAK 0.57 0.07 enet 9 0.23 6.7e-07 -5.0 -5.3 1.1e-07 0.06 0.00 0.95 FALSE
94 The Cancer Genome Atlas Stomach Adenocarcinoma CRIPAK 0.17 0.07 blup 29 0.08 1.3e-06 -3.9 -5.3 1.2e-07 0.08 0.02 0.97 FALSE
95 The Cancer Genome Atlas Thyroid Carcinoma CRIPAK 0.38 0.22 enet 12 0.25 5.4e-24 -5.4 -6.7 2.3e-11 0.01 0.00 1.00 FALSE
96 The Cancer Genome Atlas Thyroid Carcinoma FAM53A 0.05 0.03 blup 56 0.04 1.8e-04 4.0 5.4 6.3e-08 0.79 0.01 0.95 FALSE
97 The Cancer Genome Atlas Thyroid Carcinoma TMEM129 0.20 0.21 lasso 5 0.24 3.5e-23 -3.9 6.4 2.1e-10 0.49 0.99 0.01 FALSE