Best TWAS P=2.11e-14 · Best GWAS P=1e-17 conditioned to 0.00684
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | DNAJC18 | 0.09 | 0.10 | bslmm | 260 | 0.10 | 2.5e-12 | 4.5 | 6.3 | 2.6e-10 | 0.64 | 1.00 | 0.00 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | FAM53C | 0.05 | 0.02 | bslmm | 291 | 0.03 | 4.1e-04 | 7.3 | 5.6 | 2.7e-08 | 0.03 | 0.04 | 0.89 | FALSE |
3 | CommonMind | Brain Pre-frontal Cortex | PCDHA2 | 0.04 | 0.03 | blup | 478 | 0.03 | 5.0e-05 | -4.6 | -5.2 | 1.7e-07 | -0.05 | 0.07 | 0.90 | FALSE |
4 | CommonMind | Brain Pre-frontal Cortex | SPATA24 | 0.05 | 0.03 | lasso | 3 | 0.04 | 1.4e-05 | 4.9 | 5.2 | 2.0e-07 | 0.53 | 0.54 | 0.03 | FALSE |
5 | GTEx | Artery Tibial | TMEM173 | 0.24 | 0.14 | lasso | 3 | 0.13 | 1.2e-10 | 5.0 | -5.3 | 1.1e-07 | -0.43 | 1.00 | 0.00 | FALSE |
6 | GTEx | Artery Tibial | PROB1 | 0.06 | 0.09 | enet | 10 | 0.08 | 5.9e-07 | 5.0 | -6.1 | 1.0e-09 | -0.62 | 0.78 | 0.16 | FALSE |
7 | GTEx | Cells EBV-transformed lymphocytes | DNAJC18 | 0.26 | 0.09 | lasso | 2 | 0.12 | 9.7e-05 | 5.0 | 6.6 | 3.8e-11 | 0.77 | 0.04 | 0.85 | FALSE |
8 | GTEx | Cells Transformed fibroblasts | CD14 | 0.09 | 0.05 | lasso | 4 | 0.06 | 2.7e-05 | -3.8 | -5.2 | 1.5e-07 | -0.01 | 0.20 | 0.67 | FALSE |
9 | GTEx | Cells Transformed fibroblasts | DNAJC18 | 0.28 | 0.14 | lasso | 5 | 0.11 | 1.4e-08 | 5.0 | 5.2 | 1.8e-07 | 0.59 | 0.99 | 0.00 | FALSE |
10 | GTEx | Colon Transverse | TMCO6 | 0.15 | 0.06 | enet | 16 | 0.05 | 1.4e-03 | 4.3 | -5.3 | 8.6e-08 | -0.05 | 0.13 | 0.53 | FALSE |
11 | GTEx | Colon Transverse | DNAJC18 | 0.37 | -0.01 | lasso | 5 | 0.01 | 1.1e-01 | 5.0 | 6.2 | 4.2e-10 | 0.59 | 0.06 | 0.07 | FALSE |
12 | GTEx | Esophagus Gastroesophageal Junction | DNAJC18 | 0.17 | 0.01 | lasso | 10 | 0.04 | 2.0e-02 | 5.1 | 7.4 | 1.2e-13 | 0.77 | 0.06 | 0.67 | FALSE |
13 | GTEx | Esophagus Mucosa | DNAJC18 | 0.22 | 0.17 | lasso | 2 | 0.16 | 5.1e-11 | 5.0 | 5.4 | 8.3e-08 | 0.58 | 1.00 | 0.00 | FALSE |
14 | GTEx | Esophagus Mucosa | TMEM173 | 0.10 | 0.03 | enet | 20 | 0.10 | 1.8e-07 | 8.5 | -6.3 | 2.3e-10 | -0.39 | 0.05 | 0.76 | FALSE |
15 | GTEx | Esophagus Muscularis | DNAJC18 | 0.22 | 0.10 | lasso | 6 | 0.13 | 3.2e-08 | 5.0 | 6.5 | 9.9e-11 | 0.59 | 0.55 | 0.12 | TRUE |
16 | GTEx | Esophagus Muscularis | TMEM173 | 0.24 | 0.00 | lasso | 6 | 0.06 | 1.5e-04 | 4.9 | -6.0 | 2.0e-09 | -0.55 | 0.70 | 0.14 | FALSE |
17 | GTEx | Lung | PROB1 | 0.15 | 0.12 | lasso | 11 | 0.10 | 2.2e-08 | 5.0 | -5.2 | 1.5e-07 | -0.59 | 0.98 | 0.01 | FALSE |
18 | GTEx | Muscle Skeletal | DNAJC18 | 0.44 | 0.33 | lasso | 7 | 0.34 | 5.5e-34 | 5.0 | 5.2 | 2.0e-07 | 0.60 | 1.00 | 0.00 | FALSE |
19 | GTEx | Nerve Tibial | HARS | 0.07 | 0.01 | enet | 16 | 0.04 | 1.1e-03 | -4.6 | 5.7 | 1.2e-08 | -0.04 | 0.08 | 0.83 | TRUE |
20 | GTEx | Ovary | DNAJC18 | 0.33 | 0.24 | lasso | 3 | 0.21 | 7.1e-06 | 5.0 | 5.3 | 1.1e-07 | 0.59 | 0.08 | 0.09 | FALSE |
21 | GTEx | Pituitary | FAM53C | 0.28 | 0.09 | lasso | 5 | 0.02 | 8.2e-02 | 4.6 | 5.2 | 1.7e-07 | 0.06 | 0.12 | 0.08 | FALSE |
22 | GTEx | Skin Sun Exposed Lower leg | WDR55 | 0.04 | 0.01 | enet | 10 | 0.01 | 2.8e-02 | -4.5 | -5.5 | 4.9e-08 | 0.01 | 0.08 | 0.77 | FALSE |
23 | GTEx | Spleen | DNAJC18 | 0.30 | 0.13 | lasso | 5 | 0.20 | 6.5e-06 | 5.0 | 6.1 | 1.1e-09 | 0.77 | 0.10 | 0.65 | FALSE |
24 | GTEx | Thyroid | DNAJC18 | 0.38 | 0.26 | lasso | 4 | 0.26 | 1.5e-19 | 5.0 | 5.2 | 2.2e-07 | 0.58 | 1.00 | 0.00 | FALSE |
25 | GTEx | Vagina | PURA | 0.52 | 0.05 | enet | 51 | 0.09 | 3.6e-03 | 5.1 | -5.6 | 2.5e-08 | -0.13 | 0.06 | 0.10 | FALSE |
26 | METSIM | Adipose | PROB1 | 0.04 | 0.02 | enet | 23 | 0.02 | 2.9e-04 | 4.5 | -5.5 | 3.7e-08 | -0.57 | 0.92 | 0.01 | FALSE |
27 | ROSMAP | Brain Pre-frontal Cortex | WNT8A | 0.05 | 0.01 | blup | 300 | 0.03 | 1.0e-04 | -2.4 | -6.7 | 2.3e-11 | 0.00 | 0.14 | 0.78 | FALSE |
28 | ROSMAP | Brain Pre-frontal Cortex | KDM3B | 0.07 | 0.01 | blup | 307 | 0.03 | 1.0e-04 | 4.9 | -5.6 | 2.3e-08 | -0.09 | 0.24 | 0.60 | FALSE |
29 | ROSMAP | Brain Pre-frontal Cortex | PROB1 | 0.12 | 0.09 | lasso | 6 | 0.10 | 7.7e-13 | 5.0 | -5.7 | 1.5e-08 | -0.62 | 1.00 | 0.00 | FALSE |
30 | YFS | Blood | CXXC5 | 0.01 | 0.00 | bslmm | 244 | 0.01 | 2.6e-03 | 8.5 | -6.5 | 6.5e-11 | -0.48 | 0.03 | 0.66 | FALSE |
31 | YFS | Blood | TMCO6 | 0.01 | 0.00 | blup | 329 | 0.01 | 4.1e-03 | -4.4 | -5.2 | 1.8e-07 | 0.02 | 0.09 | 0.86 | FALSE |
32 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | DNAJC18 | 0.03 | 0.02 | blup | 22 | 0.02 | 6.9e-03 | 5.0 | 5.2 | 2.5e-07 | 0.60 | 0.03 | 0.44 | FALSE |
33 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MGC29506 | 0.01 | 0.00 | blup | 24 | 0.00 | 3.6e-02 | 5.0 | -5.3 | 9.5e-08 | -0.58 | 0.01 | 0.38 | FALSE |
34 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TMEM173 | 0.02 | 0.03 | blup | 7 | 0.03 | 4.6e-07 | 4.9 | -5.9 | 4.7e-09 | -0.56 | 0.07 | 0.92 | FALSE |
35 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | DNAJC18 | 0.06 | 0.05 | lasso | 2 | 0.04 | 7.3e-03 | 5.0 | 5.1 | 2.8e-07 | 0.59 | 0.01 | 0.60 | FALSE |
36 | The Cancer Genome Atlas | Esophageal Carcinoma | SPATA24 | 0.08 | 0.08 | blup | 25 | 0.08 | 1.5e-03 | 4.6 | 5.3 | 9.1e-08 | 0.60 | 0.04 | 0.56 | FALSE |
37 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | UBE2D2 | 0.05 | 0.02 | enet | 6 | 0.03 | 4.4e-04 | 5.3 | 7.6 | 2.1e-14 | 0.91 | 0.01 | 0.97 | TRUE |
38 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | BRD8 | 0.12 | 0.07 | lasso | 4 | 0.05 | 1.2e-03 | 7.0 | -6.7 | 1.7e-11 | 0.00 | 0.00 | 0.98 | TRUE |
39 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | DNAJC18 | 0.06 | 0.02 | blup | 23 | 0.02 | 9.5e-03 | 5.0 | 5.5 | 3.4e-08 | 0.60 | 0.02 | 0.46 | FALSE |
40 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | SPATA24 | 0.03 | 0.02 | blup | 24 | 0.03 | 2.8e-03 | 4.5 | 5.2 | 1.7e-07 | 0.59 | 0.03 | 0.26 | FALSE |
41 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | DNAJC18 | 0.07 | 0.09 | blup | 24 | 0.09 | 1.9e-04 | 5.0 | 5.2 | 2.2e-07 | 0.60 | 0.11 | 0.67 | FALSE |
42 | The Cancer Genome Atlas | Stomach Adenocarcinoma | SLC23A1 | 0.04 | 0.02 | blup | 28 | 0.03 | 4.3e-03 | 5.2 | -5.2 | 2.0e-07 | -0.50 | 0.01 | 0.70 | FALSE |
43 | The Cancer Genome Atlas | Thyroid Carcinoma | DNAJC18 | 0.08 | 0.10 | blup | 23 | 0.10 | 3.7e-10 | 4.8 | 5.6 | 2.5e-08 | 0.62 | 0.50 | 0.50 | FALSE |