TWAS hub - SLC23A1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Prostate Adenocarcinoma	0.0935	0.0401	2.7e-13	0.147	0.129	0.141	NA	0.144	4.2e-15	2.3e-13	1.4e-14	NA	7.9e-15
2	TCGA	Stomach Adenocarcinoma	0.0370	0.0300	5.5e-03	0.016	0.027	0.016	NA	0.019	2.3e-02	4.3e-03	2.3e-02	NA	1.6e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Overall health rating	10.1	21.7	22.0	-4.7	4.6
Financial situation satisfaction	9.0	11.1	13.4	-3.7	3.0
Hair/balding pattern: Pattern 2	8.7	11.1	13.4	-3.7	3.0
Angina	7.4	9.7	9.8	-3.1	3.1
Angina (self-reported)	7.4	9.7	10.0	-3.1	3.2
Fasting Glucose	6.4	7.6	10.0	3.2	-2.3
Unable to work because of sickness or disability	5.4	7.0	7.2	-2.7	2.6
Age at First Birth	5.0	7.2	8.8	3.0	-2.4
Heart disease (siblings)	5.0	6.2	7.5	-2.2	2.7
Had menopause	4.9	6.2	7.3	-2.2	2.7
Pulse rate, automated reading	4.9	15.8	20.8	-4.6	3.3
Commuting to job workplace: Cycle	4.8	5.8	7.3	2.7	-2.1
Illnesses of siblings	4.7	6.6	8.8	3.0	-2.1
Trunk fat-free mass	4.5	26.1	27.5	5.0	-5.2
Trunk predicted mass	4.5	25.7	27.0	4.9	-5.2
Health satisfaction	4.4	5.8	7.2	-2.7	2.1
Number of self-reported non-cancer illnesses	4.4	7.6	8.6	-2.6	2.9
Systolic Blood Pressure	4.3	21.5	28.0	-5.3	3.9
Arm predicted mass (right)	4.3	22.0	24.4	4.4	-4.9
Qualifications: CSEs or equivalent	4.2	5.6	6.4	-2.2	2.5
Arm predicted mass (left)	4.2	21.5	22.7	4.5	-4.8
High blood pressure (siblings)	4.1	6.0	9.1	-3.0	1.7
Supplements: Fish oil (including cod liver oil)	3.9	5.1	5.5	-2.3	2.2
Maternal smoking around birth	3.8	5.5	6.9	-2.0	2.6
Medication: Allopurinol	3.8	5.0	5.7	-2.4	2.1
Arm fat-free mass (right)	3.7	19.0	20.8	4.1	-4.6
Arm fat-free mass (left)	3.7	19.0	20.7	4.2	-4.5
Age at first live birth	3.6	6.4	7.9	2.8	-2.2
Number of treatments/medications taken	3.5	6.3	7.3	-2.3	2.7
Mouth/teeth dental problems	3.5	5.3	6.2	2.5	-2.1
Whole body fat-free mass	3.5	19.8	20.3	4.4	-4.5
Medication: Aspirin	3.5	4.6	6.6	-2.6	1.6
Whole body water mass	3.5	20.0	20.5	4.4	-4.5
Commuting to job workplace: Public transport	3.5	4.1	5.1	1.8	-2.3
Medication: Atorvastatin	3.5	4.3	4.8	-2.2	2.0
Basal cell carcinoma (self-reported)	3.5	4.2	5.3	1.7	-2.3
Medication: Atenolol	3.4	4.3	6.2	-2.5	1.6
Had major operations	3.4	4.0	4.0	-2.0	2.0
Eye problems/disorders: Diabetes related eye disease	3.2	3.5	4.0	1.7	-2.0
Migraine (self-reported)	3.2	4.0	5.3	-2.3	1.6
Chest pain or discomfort	3.2	4.6	6.3	-1.7	2.5
Diverticular disease/diverticulitis (self-reported)	3.1	3.7	4.9	1.6	-2.2
Impedance of arm (left)	3.1	14.6	18.6	-3.2	4.3
Wheeze or whistling in the chest in last year	3.1	5.5	6.1	-2.2	2.5
Pulse wave peak to peak time	3.1	3.7	3.9	1.9	-2.0
Mother’s age at death	3.1	3.9	7.0	2.6	-0.9
High cholesterol (Self-reported)	3.1	5.5	5.9	-2.4	2.2
Basal metabolic rate	3.1	17.1	17.5	4.1	-4.2
Ovarian Cancer	3.0	4.0	6.2	2.5	-1.3
Sensitivity / hurt feelings	3.0	5.2	6.2	-2.1	2.5
Mouth/teeth dental problems: Dentures	3.0	5.1	6.4	-2.5	2.0
Birth weight	3.0	6.6	7.5	2.7	-2.4
Leg pain on walking	3.0	3.8	5.3	-1.5	2.3
Reason for reducing amount of alcohol drunk: Health precaution	2.9	3.4	5.8	1.0	-2.4
Medication: Aspirin	2.9	3.9	5.2	-2.3	1.6
HbA1C	2.8	3.1	3.4	1.8	-1.7
Sitting height	2.8	20.1	23.9	4.9	-4.0
Father’s age at death	2.8	3.8	3.9	2.0	-1.9
Bipolar Disorder (2011)	2.7	2.6	4.2	1.0	-2.0
Medication: Co-codamol	2.7	3.1	3.9	-2.0	1.5
Medication: Gliclazide	2.7	3.0	4.2	-1.4	2.1
Heart disease (mother)	2.6	3.2	3.6	-1.7	1.9
Pulse rate	2.5	4.3	5.2	-2.3	1.8
Pain experienced in last month	2.5	4.2	4.9	1.9	-2.2
Hearing difficulty/problems: Yes	2.4	3.7	5.9	-2.4	1.2
Hip circumference	2.4	10.3	11.4	3.4	-3.0
Time employed in main current job	2.4	2.8	2.9	-1.6	1.7
Happiness	2.4	2.9	3.2	-1.8	1.6
Nervous feelings	2.3	4.3	5.1	-2.3	1.9
Impedance of arm (right)	2.3	10.9	14.0	-2.8	3.7
Standing height	2.3	22.6	27.7	5.3	-4.2
Number of operations (self-reported)	2.3	3.4	3.5	-1.9	1.8
Ever used hormone-replacement therapy (HRT)	2.2	2.8	3.2	-1.8	1.6
Taking other prescription medications	2.2	3.3	4.9	-1.3	2.2
Medication: Cholesterol lowering	2.2	3.5	4.0	-1.7	2.0
Mouth/teeth dental problems: Loose teeth	2.2	2.6	4.6	-0.8	2.1
Comparative height size at age 10	2.2	12.1	14.0	3.7	-3.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.2	2.6	3.7	-1.9	1.2
Forced expiratory volume in 1-second (FEV1), predicted	2.2	4.5	4.9	2.2	-2.0
Vascular/heart problems diagnosed by doctor	2.2	5.9	7.9	2.8	-2.0
Systolic blood pressure, automated reading	2.1	6.0	7.9	-2.8	2.0
High blood pressure	2.1	5.8	8.2	-2.9	1.9
Illness, injury, bereavement, stress in last 2 years	2.1	2.6	3.4	1.3	-1.9
Rheumatoid Arthritis	2.0	2.8	3.6	-1.9	1.4
Cardiovascular Disease	2.0	6.7	8.1	-2.8	2.3
Frequency of tenseness / restlessness in last 2 weeks	2.0	3.1	4.0	-2.0	1.5
Pulse wave Arterial Stiffness index	2.0	2.3	2.6	-1.4	1.6
Medication: Ventolin 100micrograms inhaler	2.0	2.6	3.8	-1.2	2.0
Leg fat-free mass (right)	2.0	10.7	11.5	3.4	-3.1
Leg predicted mass (right)	2.0	10.6	11.6	3.4	-3.1
Irritability	2.0	3.4	3.5	-1.9	1.8
Mean time to correctly identify matches	1.9	3.6	4.5	-1.7	2.1
Age at last live birth	1.9	2.7	2.9	1.7	-1.6
Average weekly champagne plus white wine intake	1.9	2.6	3.2	1.8	-1.4
Ulcerative Colitis	1.8	2.7	2.9	1.6	-1.7
Leg fat-free mass (left)	1.8	9.3	9.9	3.1	-3.0
Fed-up feelings	1.8	3.2	3.2	-1.8	1.8
Bilateral oophorectomy (both ovaries removed)	1.8	2.1	2.9	-1.7	1.1
Financial difficulties in last 2 years	1.8	2.4	3.5	-1.9	1.2
Qualifications: A levels/AS levels or equivalent	1.8	4.1	4.6	2.2	-1.9
Commuting to job workplace: Car/motor vehicle	1.8	2.1	2.7	-1.6	1.2
Hypertension (Self-reported)	1.8	5.0	6.9	-2.6	1.7
Medication: Omeprazole (e.g. Zanprol)	1.8	2.2	2.5	-1.3	1.6
Verbal and Numeric Reasoning (VNR)	1.7	4.0	4.2	2.0	-2.0
Type 2 Diabetes (T2D) (2012)	1.7	2.0	2.3	1.5	-1.3
Hypothyroidism (self reported)	1.7	3.9	5.6	-2.4	1.5
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.8	6.6	-2.6	1.0
Chronic bronchitis/emphysema (father)	1.7	2.0	2.5	-1.2	1.6
Leg predicted mass (left)	1.7	9.1	9.4	3.1	-3.0
Alcohol usually taken with meals	1.7	2.7	2.9	1.7	-1.6
Other serious medical condition/disability diagnosed by doctor	1.6	2.0	3.3	-0.9	1.8
Medication: Metformin	1.6	2.3	2.4	-1.5	1.5
Serious illness, injury or assault to yourself	1.6	1.9	3.1	-0.9	1.8
Gout (self-reported)	1.6	2.2	2.6	-1.4	1.6
Medication: Blood pressure	1.6	2.8	4.5	-2.1	1.1
Impedance of whole body	1.6	8.1	11.0	-2.3	3.3
Heart attack	1.5	1.9	2.0	-1.3	1.4
Illnesses of mother	1.5	1.8	3.3	1.8	-0.6
Heart attack/myocardial infarction (self-reported)	1.5	2.0	2.0	-1.4	1.4
Ulcerative Colitis (UC)	1.4	2.7	3.6	1.9	-1.3
Height	1.4	26.8	34.3	5.9	-4.4
Respiratory disease	1.4	3.0	3.2	-1.7	1.8
Neuroticism score	1.4	2.9	3.1	-1.7	1.8
Medication for pain relief, constipation, heartburn	1.4	2.5	2.7	1.7	-1.5
Knee pain experienced in last month	1.4	2.2	3.2	-1.1	1.8
Guilty feelings	1.4	2.1	3.2	-1.8	1.0
Allergy	1.3	3.1	4.1	1.4	-2.0
Medication: Simvastatin	1.3	2.0	2.5	-1.6	1.2
Hypothyroidism/myxoedema (self-reported)	1.3	2.6	4.0	-2.0	1.1
Shortness of breath walking on level ground	1.3	1.5	2.0	-1.0	1.4
Neck or shoulder pain in last month	1.3	1.9	2.0	-1.4	1.3
Medication: Omeprazole	1.3	1.5	2.2	-1.5	0.9
Friendships satisfaction	1.3	1.6	2.6	-1.6	0.8
Neuroticism (Nagel 2018)	1.2	2.8	3.5	-1.4	1.9
Alzheimer’s Disease (in mother)	1.2	1.5	2.2	-0.8	-1.5
Stomach or abdominal pain in last month	1.2	1.5	1.5	-1.2	1.2
Weight	1.2	6.0	6.1	2.5	-2.4
Alcohol intake versus 10 years previously	1.2	1.8	2.9	-0.8	1.7
Birth weight of first child	1.2	2.1	3.6	1.9	-0.8
Medication for cholesterol, blood pressure or diabetes	1.2	1.9	2.6	1.6	-1.1
Exposure to tobacco smoke outside home	1.2	1.6	3.1	-1.7	0.2
Average weekly red wine intake	1.2	1.7	2.7	1.7	-0.8
Risk taking	1.2	1.8	2.6	1.6	-1.0
Cholesterol lowering medication	1.2	1.7	2.6	-1.6	1.0
Bipolar Disorder (2018)	1.1	1.7	3.1	0.5	-1.8
Intelligence (Savage-Jansen 2018)	1.1	3.4	4.0	2.0	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.4	2.4	-1.6	0.7
Fluid intelligence score	1.1	2.3	2.3	1.5	-1.5
Ever had bowel cancer screening	1.1	1.2	1.4	1.0	-1.2
Illnesses of father: None of the above (group 1)	1.1	1.4	2.5	1.6	-0.5
Irritable Bowel Disease (IBD)	1.0	2.4	3.7	1.9	-1.1
Heel T-Score	1.0	7.8	14.0	-3.7	1.2
Hand grip strength (left)	1.0	2.6	2.8	1.7	-1.6
Number of incorrect matches in round	1.0	1.6	2.1	1.4	-1.1
Had other major operations	1.0	1.2	2.1	1.5	-0.5
Falls in the last year	1.0	1.4	2.3	-1.5	0.6
Alcohol intake frequency.	1.0	2.3	3.2	-1.2	1.8
Long-standing illness, disability or infirmity	1.0	1.5	1.6	-1.2	1.3
Mineral and other dietary supplements	1.0	1.4	1.4	1.2	-1.2
Depression (Nagel 2018)	0.9	1.4	2.5	-1.6	0.5
Allergy or Eczema	0.9	2.3	4.0	-0.7	2.0
Average weekly spirits intake	0.9	1.1	1.3	1.0	-1.1
Hayfever, allergic rhinitis or eczema	0.9	2.0	3.3	-0.8	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	3.5	-1.9	0.7
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	1.4	-1.0	1.2
Peak expiratory flow (PEF)	0.9	2.0	2.5	-1.6	1.2
Worry too long after embarrassment	0.9	1.5	2.5	-1.6	0.7
Commuting to job workplace: Walk	0.9	1.0	1.8	-0.5	1.3
Illnesses of father: High blood pressure	0.9	1.2	1.9	-0.6	-1.4
Fractured/broken bones in last 5 years	0.9	1.2	1.8	1.3	-0.7
Lung FEV1/FVC ratio	0.8	4.3	7.5	-2.7	1.1
Hair/balding pattern: Pattern 4	0.8	1.9	2.8	1.7	-1.0
Medication for cholesterol	0.8	1.1	2.2	1.5	-0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	1.3	-1.1	0.7
Breast cancer (self-reported)	0.8	1.0	1.0	-1.0	1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.6	1.9	-1.4	1.2
Medication: Paracetamol	0.8	1.2	1.8	-1.4	0.8
Ever smoked	0.8	1.4	1.8	-1.0	1.4
Ever had prostate specific antigen (PSA) test	0.8	0.9	0.9	1.0	-0.9
Ever depressed for a whole week	0.8	1.0	1.6	0.6	-1.3
Bipolar Disorder or Schizophrenia	0.7	1.7	2.1	1.1	-1.5
Depressed Affect (Nagel 2018)	0.7	1.4	2.3	-0.7	1.5
Neuroticism (2016)	0.7	1.0	1.0	-1.0	1.0
Medication: Levothyroxine sodium	0.7	1.1	2.0	-1.4	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	1.1	1.0	-0.9
Medication: Lansoprazole	0.7	0.8	0.8	-0.8	0.9
Forced vital capacity (FVC), Best measure	0.7	2.6	2.7	1.5	-1.7
Handedness (chirality/laterality): Left-handed	0.7	0.8	1.5	0.3	-1.2
Myopia	0.7	1.0	1.0	1.0	-1.0
Alzheimer’s Disease (including proxy)	0.6	0.8	1.5	-1.2	-0.4
Mean Putamen Volume	0.6	0.7	1.0	-0.6	1.0
Schizophrenia (2014)	0.6	1.3	1.3	1.1	-1.1
Triglycerides	0.6	0.9	1.8	0.3	-1.3
Neuroticism	0.6	1.5	1.8	-1.1	1.3
Frequency of depressed mood in last 2 weeks	0.6	0.8	1.1	-1.1	0.7
Relative age voice broke	0.6	0.9	1.5	1.2	-0.6
Past tobacco smoking	0.6	1.1	1.4	1.2	-0.9
Forced vital capacity (FVC)	0.6	2.4	2.6	1.5	-1.6
Frequency of tiredness / lethargy in last 2 weeks	0.6	1.0	1.6	-0.7	1.2
Headache pain in last month	0.6	1.1	1.6	-1.2	0.8
Number of children fathered	0.6	0.7	1.3	0.0	1.1
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.3	-0.3	1.1
Smoking status: Previous	0.6	0.9	1.2	-1.1	0.8
Qualifications: nursing, teaching	0.6	0.9	1.3	1.1	-0.8
Hearing aid user	0.6	0.7	1.2	-1.1	0.3
Pain type(s) experienced in last month: Hip pain	0.6	0.7	1.2	-0.5	1.1
Diastolic blood pressure, automated reading	0.6	1.9	3.1	-1.7	0.9
Pack years of smoking	0.6	0.8	1.0	-1.0	0.8
Crohns Disease (2012)	0.5	0.8	1.4	1.2	-0.6
Lupus	0.5	0.8	1.6	0.0	1.3
Blood Platelet Count	0.5	5.7	8.1	-2.9	1.8
Waist Hip Ratio (WHR)	0.5	2.1	4.2	-2.1	0.2
Medication for hormone replacement therapy	0.5	0.6	0.9	-0.9	0.5
Trunk fat percentage	0.5	2.0	2.2	-1.4	1.5
Hand grip strength (right)	0.5	1.4	1.4	1.2	-1.2
Townsend deprivation index at recruitment	0.5	0.7	0.9	-1.0	0.7
Asthma	0.5	0.9	1.3	-0.8	1.1
Loud music exposure frequency	0.5	0.6	0.8	-0.6	0.9
Blood clot in the leg (DVT)	0.5	0.6	0.7	-0.7	0.8
Illnesses of father: Heart disease	0.5	0.7	1.1	-1.0	0.6
Arm fat percentage (left)	0.5	2.2	2.2	-1.5	1.5
Asthma (self-reported)	0.5	0.9	1.3	-0.7	1.1
Osteoporosis (self-reported)	0.5	0.6	1.2	-0.2	1.1
Medication: Blood pressure	0.5	0.9	1.4	-1.2	0.7
Alzheimer’s Disease (in father)	0.4	0.4	0.8	0.9	-0.2
HDL Cholesterol	0.4	0.7	0.7	-0.8	-0.8
Lung FVC	0.4	1.9	3.7	-1.9	0.2
Diabetes (father)	0.4	0.5	0.6	0.6	-0.8
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	0.8	0.9	-0.1
Waist circumference	0.4	1.6	2.0	1.0	-1.4
Arm fat percentage (right)	0.4	1.6	1.7	-1.3	1.2
Exposure to tobacco smoke at home	0.4	0.4	0.8	-0.9	0.1
Breastfed as a baby	0.4	0.5	0.6	-0.8	0.6
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.3	-1.1	0.1
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.5	-0.7	0.7
Comparative body size at age 10	0.4	1.1	1.6	0.8	-1.2
Supplements: Vitamin C	0.4	0.4	0.7	0.9	-0.3
Tinnitus: Yes, now most or all of the time	0.4	0.5	0.9	-0.9	0.4
Average weekly beer plus cider intake	0.4	0.5	0.6	-0.8	0.7
Schizophrenia (2018)	0.3	0.6	1.1	1.0	-0.4
Worry (Nagel 2018)	0.3	0.7	0.8	-0.9	0.8
Body Mass Index (BMI) (2010)	0.3	0.4	0.5	0.7	-0.5
Blood Red Count	0.3	3.3	5.4	-2.3	1.1
Chronotype (morning person)	0.3	0.6	0.9	-0.6	1.0
Age when periods started (menarche)	0.3	0.7	1.3	0.4	-1.1
Hearing difficulty/problems with background noise	0.3	0.5	0.7	-0.8	0.6
Diabetes (self-reported)	0.3	0.4	0.5	-0.6	0.7
Noisy workplace	0.3	0.3	0.4	0.5	0.7
Lung cancer (father)	0.3	0.3	0.5	-0.4	0.7
Length of working week for main job	0.3	0.3	0.4	0.4	0.6
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.6	0.3	-0.7
Body fat percentage	0.3	1.1	1.2	-1.0	1.1
Emphysema/chronic bronchitis	0.3	0.4	0.4	-0.7	0.6
Medication: Seretide 50 evohaler	0.3	0.4	0.6	0.8	-0.4
Suffer from ‘nerves’	0.3	0.5	1.0	-1.0	0.2
Mouth/teeth dental problems: Mouth ulcers	0.3	0.4	0.7	0.8	-0.3
Ever taken oral contraceptive pill	0.3	0.4	0.6	0.8	0.4
Alcohol drinker status: Never	0.3	0.3	0.5	-0.7	0.3
Age started oral contraceptive pill	0.3	0.4	0.7	0.9	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.4	-0.6	0.6
Schizophrenia vs Biploar Disorder	0.2	0.2	0.3	0.5	0.5
Reaction Time	0.2	0.4	0.6	-0.6	0.7
Relative age of first facial hair	0.2	0.5	0.6	0.6	-0.8
Ever had hysterectomy (womb removed)	0.2	0.2	0.3	-0.6	-0.2
Pack years adult smoking proportion	0.2	0.3	0.4	-0.6	0.4
Impedance of leg (right)	0.2	1.1	1.4	-0.9	1.2
Current tobacco smoking	0.2	0.3	0.3	0.5	-0.5
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.5	-0.1	-0.7
Medication: Ramipril	0.2	0.3	0.5	-0.7	-0.2
Worrier / anxious feelings	0.2	0.4	0.6	-0.6	0.7
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.7	-0.4
Number of live births	0.2	0.3	0.4	-0.6	-0.5
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	0.0	0.7
Prospective memory result	0.2	0.3	0.5	-0.7	0.2
Pulse wave reflection index	0.2	0.3	0.4	-0.5	0.6
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.7	-0.2	0.9
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.2	-0.5	0.5
Medication: Paracetamol	0.2	0.4	0.4	-0.6	0.6
Glaucoma (self-reported)	0.2	0.2	0.3	0.2	0.6
Medication: Amlodipine	0.2	0.3	0.5	0.3	-0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.5	0.7	0.4
Qualifications: College or University degree	0.2	0.6	0.9	1.0	-0.5
Number of full sisters	0.2	0.2	0.4	-0.2	-0.6
Family relationship satisfaction	0.2	0.3	0.5	-0.7	-0.1
Mood swings	0.2	0.4	0.7	-0.1	0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.4	-0.1	0.6
Smoking status: Current	0.2	0.4	0.4	0.5	-0.7
Miserableness	0.2	0.4	0.4	-0.6	0.6
Eye problems/disorders: Glaucoma	0.2	0.3	0.4	-0.4	0.6
Alcohol drinker status: Previous	0.2	0.3	0.3	-0.4	0.6
Leg fat mass (left)	0.2	0.8	0.8	0.9	-0.9
Crohns Disease (2017)	0.1	0.3	0.4	0.7	-0.3
Major Depression (MDD)	0.1	0.1	0.2	-0.4	0.2
Breast Cancer	0.1	0.3	0.7	0.0	-0.8
LDL Cholesterol	0.1	0.1	0.2	-0.5	0.2
Primary Biliary Cirrhosis	0.1	0.2	0.3	0.3	-0.5
Vitamin and mineral supplements	0.1	0.1	0.2	-0.4	0.0
Supplements: Zinc	0.1	0.1	0.1	0.3	-0.2
Diabetes (mother)	0.1	0.1	0.1	-0.4	0.1
Severe depression (siblings)	0.1	0.1	0.2	-0.5	-0.3
Average weekly fortified wine intake	0.1	0.1	0.1	-0.3	-0.4
Multivitamins +/- minerals	0.1	0.1	0.2	0.2	0.4
Supplements: Glucosamine	0.1	0.1	0.2	-0.2	0.5
High blood pressure (mother)	0.1	0.1	0.1	0.2	0.3
Body mass index (BMI)	0.1	0.2	0.5	0.2	-0.7
Impedance of leg (left)	0.1	0.6	1.1	-0.3	1.1
Pain all over the body in last month	0.1	0.1	0.1	0.1	-0.3
Forced expiratory volume in 1-second (FEV1)	0.1	0.3	0.6	0.2	-0.7
Depression (self-reported)	0.1	0.1	0.2	0.5	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.1	0.2	0.4	0.2	-0.6
Arm fat mass (right)	0.1	0.2	0.4	0.3	-0.6
Number of full brothers	0.1	0.2	0.2	0.5	-0.3
Whole body fat mass	0.1	0.3	0.4	0.7	-0.5
Leg fat mass (right)	0.1	0.5	0.5	0.7	-0.7
Back pain experienced in last month	0.1	0.1	0.2	-0.4	0.4
Medication: Lisinopril	0.1	0.2	0.2	-0.3	0.5
Prostate Cancer	0.0	0.0	0.0	-0.2	-0.0
Coronary Artery Disease (CAD)	0.0	0.1	0.1	-0.2	-0.3
Blood Eosinophil Count	0.0	0.4	0.6	-0.4	0.8
Blood White Count	0.0	0.2	0.3	0.5	0.2
BMI	0.0	0.2	0.2	0.4	-0.4
Smoking Status	0.0	0.1	0.1	0.3	-0.2
Type 2 Diabetes (T2D) (2018)	0.0	0.1	0.1	0.1	0.4
Hair Pigment	0.0	0.8	1.3	0.5	-1.1
Tanning	0.0	0.1	0.2	-0.4	-0.2
Trunk fat mass	0.0	0.1	0.1	0.3	-0.2
Qualifications: None of the above	0.0	0.0	0.1	-0.3	-0.0
Tense / ‘highly strung’	0.0	0.1	0.1	0.1	-0.3
Leg fat percentage (right)	0.0	0.1	0.1	-0.3	0.1
Eye problems/disorders: None of the above	0.0	0.0	0.1	-0.3	0.0
Medication: Ibuprofen	0.0	0.0	0.0	0.2	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.0	0.0	0.0	-0.1	-0.0
Illnesses of siblings: Diabetes	0.0	0.1	0.1	-0.0	-0.3
Loneliness, isolation	0.0	0.0	0.0	0.1	0.2
Diabetes diagnosed by doctor	0.0	0.0	0.1	-0.1	0.3
Eye problems/disorders: Cataract	0.0	0.1	0.1	0.3	0.2
Osteoarthritis (self-reported)	0.0	0.1	0.1	-0.3	-0.2
Arm fat mass (left)	0.0	0.2	0.2	0.4	-0.5
Wears glasses or contact lenses	0.0	0.1	0.1	-0.3	0.2
Medication: Bendroflumethiazide	0.0	0.0	0.0	0.0	0.0
Leg fat percentage (left)	0.0	0.0	0.0	0.1	-0.1
Supplements: Calcium	0.0	0.0	0.0	0.1	0.0

Hub : Genes

SLC23A1

Models

Trait associations