Hub : Genes

SLC23A1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Prostate Adenocarcinoma 0.0935 0.0401 2.7e-13 0.147 0.129 0.141 NA 0.144 4.2e-15 2.3e-13 1.4e-14 NA 7.9e-15
2 TCGA Stomach Adenocarcinoma 0.0370 0.0300 5.5e-03 0.016 0.027 0.016 NA 0.019 2.3e-02 4.3e-03 2.3e-02 NA 1.6e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 1.1 1.7 3.1 0.5 -1.8
Bipolar Disorder or Schizophrenia 0.7 1.7 2.1 1.1 -1.5
Depressed Affect (Nagel 2018) 0.7 1.4 2.3 -0.7 1.5
Depression (Nagel 2018) 0.9 1.4 2.5 -1.6 0.5
Intelligence (Savage-Jansen 2018) 1.1 3.4 4.0 2.0 -1.7
Neuroticism (Nagel 2018) 1.2 2.8 3.5 -1.4 1.9
Schizophrenia (2018) 0.3 0.6 1.1 1.0 -0.4
Schizophrenia vs Biploar Disorder 0.2 0.2 0.3 0.5 0.5
Worry (Nagel 2018) 0.3 0.7 0.8 -0.9 0.8
Alzheimer’s Disease (in mother) 1.2 1.5 2.2 -0.8 -1.5
Alzheimer’s Disease (in father) 0.4 0.4 0.8 0.9 -0.2
Alzheimer’s Disease (including proxy) 0.6 0.8 1.5 -1.2 -0.4
Crohns Disease (2017) 0.1 0.3 0.4 0.7 -0.3
Irritable Bowel Disease (IBD) 1.0 2.4 3.7 1.9 -1.1
Ulcerative Colitis (UC) 1.4 2.7 3.6 1.9 -1.3
Major Depression (MDD) 0.1 0.1 0.2 -0.4 0.2
Reaction Time 0.2 0.4 0.6 -0.6 0.7
Verbal and Numeric Reasoning (VNR) 1.7 4.0 4.2 2.0 -2.0
Breast Cancer 0.1 0.3 0.7 0.0 -0.8
Ovarian Cancer 3.0 4.0 6.2 2.5 -1.3
Prostate Cancer 0.0 0.0 0.0 -0.2 -0.0
Age at First Birth 5.0 7.2 8.8 3.0 -2.4
Bipolar Disorder (2011) 2.7 2.6 4.2 1.0 -2.0
Body Mass Index (BMI) (2010) 0.3 0.4 0.5 0.7 -0.5
Coronary Artery Disease (CAD) 0.0 0.1 0.1 -0.2 -0.3
Crohns Disease (2012) 0.5 0.8 1.4 1.2 -0.6
Mean Putamen Volume 0.6 0.7 1.0 -0.6 1.0
Fasting Glucose 6.4 7.6 10.0 3.2 -2.3
HbA1C 2.8 3.1 3.4 1.8 -1.7
HDL Cholesterol 0.4 0.7 0.7 -0.8 -0.8
LDL Cholesterol 0.1 0.1 0.2 -0.5 0.2
Lupus 0.5 0.8 1.6 0.0 1.3
Neuroticism (2016) 0.7 1.0 1.0 -1.0 1.0
Primary Biliary Cirrhosis 0.1 0.2 0.3 0.3 -0.5
Rheumatoid Arthritis 2.0 2.8 3.6 -1.9 1.4
Schizophrenia (2014) 0.6 1.3 1.3 1.1 -1.1
Triglycerides 0.6 0.9 1.8 0.3 -1.3
Type 2 Diabetes (T2D) (2012) 1.7 2.0 2.3 1.5 -1.3
Ulcerative Colitis 1.8 2.7 2.9 1.6 -1.7
Blood Eosinophil Count 0.0 0.4 0.6 -0.4 0.8
Blood Platelet Count 0.5 5.7 8.1 -2.9 1.8
Blood Red Count 0.3 3.3 5.4 -2.3 1.1
Blood White Count 0.0 0.2 0.3 0.5 0.2
Heel T-Score 1.0 7.8 14.0 -3.7 1.2
BMI 0.0 0.2 0.2 0.4 -0.4
Height 1.4 26.8 34.3 5.9 -4.4
Waist Hip Ratio (WHR) 0.5 2.1 4.2 -2.1 0.2
Systolic Blood Pressure 4.3 21.5 28.0 -5.3 3.9
Smoking Status 0.0 0.1 0.1 0.3 -0.2
Allergy or Eczema 0.9 2.3 4.0 -0.7 2.0
Cardiovascular Disease 2.0 6.7 8.1 -2.8 2.3
Hypothyroidism (self reported) 1.7 3.9 5.6 -2.4 1.5
Respiratory disease 1.4 3.0 3.2 -1.7 1.8
Type 2 Diabetes (T2D) (2018) 0.0 0.1 0.1 0.1 0.4
Lung FEV1/FVC ratio 0.8 4.3 7.5 -2.7 1.1
Lung FVC 0.4 1.9 3.7 -1.9 0.2
Neuroticism 0.6 1.5 1.8 -1.1 1.3
Chronotype (morning person) 0.3 0.6 0.9 -0.6 1.0
Hair Pigment 0.0 0.8 1.3 0.5 -1.1
Tanning 0.0 0.1 0.2 -0.4 -0.2
Hand grip strength (left) 1.0 2.6 2.8 1.7 -1.6
Number of treatments/medications taken 3.5 6.3 7.3 -2.3 2.7
Average weekly spirits intake 0.9 1.1 1.3 1.0 -1.1
Sensitivity / hurt feelings 3.0 5.2 6.2 -2.1 2.5
Frequency of depressed mood in last 2 weeks 0.6 0.8 1.1 -1.1 0.7
Hearing difficulty/problems: Yes 2.4 3.7 5.9 -2.4 1.2
Relative age of first facial hair 0.2 0.5 0.6 0.6 -0.8
Other serious medical condition/disability diagnosed by doctor 1.6 2.0 3.3 -0.9 1.8
Ever used hormone-replacement therapy (HRT) 2.2 2.8 3.2 -1.8 1.6
Ever had hysterectomy (womb removed) 0.2 0.2 0.3 -0.6 -0.2
Systolic blood pressure, automated reading 2.1 6.0 7.9 -2.8 2.0
Eye problems/disorders: Diabetes related eye disease 3.2 3.5 4.0 1.7 -2.0
Angina 7.4 9.7 9.8 -3.1 3.1
Medication for hormone replacement therapy 0.5 0.6 0.9 -0.9 0.5
Vitamin and mineral supplements 0.1 0.1 0.2 -0.4 0.0
Supplements: Zinc 0.1 0.1 0.1 0.3 -0.2
Medication: Co-codamol 2.7 3.1 3.9 -2.0 1.5
Medication: Metformin 1.6 2.3 2.4 -1.5 1.5
Diabetes (father) 0.4 0.5 0.6 0.6 -0.8
Diabetes (mother) 0.1 0.1 0.1 -0.4 0.1
Severe depression (siblings) 0.1 0.1 0.2 -0.5 -0.3
Pack years adult smoking proportion 0.2 0.3 0.4 -0.6 0.4
Impedance of leg (right) 0.2 1.1 1.4 -0.9 1.2
Leg fat-free mass (left) 1.8 9.3 9.9 3.1 -3.0
Trunk fat percentage 0.5 2.0 2.2 -1.4 1.5
Hand grip strength (right) 0.5 1.4 1.4 1.2 -1.2
Townsend deprivation index at recruitment 0.5 0.7 0.9 -1.0 0.7
Current tobacco smoking 0.2 0.3 0.3 0.5 -0.5
Average weekly fortified wine intake 0.1 0.1 0.1 -0.3 -0.4
Maternal smoking around birth 3.8 5.5 6.9 -2.0 2.6
Fed-up feelings 1.8 3.2 3.2 -1.8 1.8
Frequency of unenthusiasm / disinterest in last 2 weeks 1.1 1.4 2.4 -1.6 0.7
Relative age voice broke 0.6 0.9 1.5 1.2 -0.6
Taking other prescription medications 2.2 3.3 4.9 -1.3 2.2
Age when periods started (menarche) 0.3 0.7 1.3 0.4 -1.1
Bilateral oophorectomy (both ovaries removed) 1.8 2.1 2.9 -1.7 1.1
Heel bone mineral density (BMD) T-score, automated (left) 1.7 3.8 6.6 -2.6 1.0
Tinnitus: Yes, but not now, but have in the past 0.4 0.4 0.8 0.9 -0.1
Qualifications: CSEs or equivalent 4.2 5.6 6.4 -2.2 2.5
Serious illness, injury or assault to yourself 1.6 1.9 3.1 -0.9 1.8
High blood pressure 2.1 5.8 8.2 -2.9 1.9
Hayfever, allergic rhinitis or eczema 0.9 2.0 3.3 -0.8 1.8
Multivitamins +/- minerals 0.1 0.1 0.2 0.2 0.4
Stomach or abdominal pain in last month 1.2 1.5 1.5 -1.2 1.2
Supplements: Glucosamine 0.1 0.1 0.2 -0.2 0.5
Diverticular disease/diverticulitis (self-reported) 3.1 3.7 4.9 1.6 -2.2
Medication: Atenolol 3.4 4.3 6.2 -2.5 1.6
Medication: Levothyroxine sodium 0.7 1.1 2.0 -1.4 0.5
Sitting height 2.8 20.1 23.9 4.9 -4.0
Chronic bronchitis/emphysema (father) 1.7 2.0 2.5 -1.2 1.6
High blood pressure (mother) 0.1 0.1 0.1 0.2 0.3
Body mass index (BMI) 0.1 0.2 0.5 0.2 -0.7
Impedance of leg (left) 0.1 0.6 1.1 -0.3 1.1
Leg predicted mass (left) 1.7 9.1 9.4 3.1 -3.0
Trunk fat mass 0.0 0.1 0.1 0.3 -0.2
Waist circumference 0.4 1.6 2.0 1.0 -1.4
Number of incorrect matches in round 1.0 1.6 2.1 1.4 -1.1
Past tobacco smoking 0.6 1.1 1.4 1.2 -0.9
Alcohol usually taken with meals 1.7 2.7 2.9 1.7 -1.6
Nervous feelings 2.3 4.3 5.1 -2.3 1.9
Frequency of tenseness / restlessness in last 2 weeks 2.0 3.1 4.0 -2.0 1.5
Hearing difficulty/problems with background noise 0.3 0.5 0.7 -0.8 0.6
Hair/balding pattern: Pattern 2 8.7 11.1 13.4 -3.7 3.0
Had menopause 4.9 6.2 7.3 -2.2 2.7
Had other major operations 1.0 1.2 2.1 1.5 -0.5
Forced vital capacity (FVC) 0.6 2.4 2.6 1.5 -1.6
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 3.5 -1.9 0.7
Ever unenthusiastic/disinterested for a whole week 0.2 0.3 0.5 -0.1 -0.7
Qualifications: None of the above 0.0 0.0 0.1 -0.3 -0.0
Financial difficulties in last 2 years 1.8 2.4 3.5 -1.9 1.2
Mouth/teeth dental problems 3.5 5.3 6.2 2.5 -2.1
Heart attack 1.5 1.9 2.0 -1.3 1.4
Allergy 1.3 3.1 4.1 1.4 -2.0
Pain all over the body in last month 0.1 0.1 0.1 0.1 -0.3
Diabetes (self-reported) 0.3 0.4 0.5 -0.6 0.7
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 1.4 -1.0 1.2
Medication: Ramipril 0.2 0.3 0.5 -0.7 -0.2
Medication: Simvastatin 1.3 2.0 2.5 -1.6 1.2
Fluid intelligence score 1.1 2.3 2.3 1.5 -1.5
Illnesses of siblings 4.7 6.6 8.8 3.0 -2.1
Neuroticism score 1.4 2.9 3.1 -1.7 1.8
Weight 1.2 6.0 6.1 2.5 -2.4
Impedance of arm (right) 2.3 10.9 14.0 -2.8 3.7
Arm fat percentage (right) 0.4 1.6 1.7 -1.3 1.2
Trunk fat-free mass 4.5 26.1 27.5 5.0 -5.2
Hip circumference 2.4 10.3 11.4 3.4 -3.0
Time employed in main current job 2.4 2.8 2.9 -1.6 1.7
Alcohol intake versus 10 years previously 1.2 1.8 2.9 -0.8 1.7
Father’s age at death 2.8 3.8 3.9 2.0 -1.9
Worrier / anxious feelings 0.2 0.4 0.6 -0.6 0.7
Frequency of tiredness / lethargy in last 2 weeks 0.6 1.0 1.6 -0.7 1.2
Falls in the last year 1.0 1.4 2.3 -1.5 0.6
Hair/balding pattern: Pattern 3 0.2 0.3 0.6 0.7 -0.4
Number of live births 0.2 0.3 0.4 -0.6 -0.5
Forced expiratory volume in 1-second (FEV1) 0.1 0.3 0.6 0.2 -0.7
Pulse rate 2.5 4.3 5.2 -2.3 1.8
Happiness 2.4 2.9 3.2 -1.8 1.6
Noisy workplace 0.3 0.3 0.4 0.5 0.7
Qualifications: A levels/AS levels or equivalent 1.8 4.1 4.6 2.2 -1.9
Serious illness, injury or assault of a close relative in last 2 years 0.2 0.2 0.4 0.0 0.7
Mouth/teeth dental problems: Dentures 3.0 5.1 6.4 -2.5 2.0
Asthma 0.5 0.9 1.3 -0.8 1.1
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 1.1 1.0 -0.9
Medication: Cholesterol lowering 2.2 3.5 4.0 -1.7 2.0
Depression (self-reported) 0.1 0.1 0.2 0.5 0.2
Medication: Lansoprazole 0.7 0.8 0.8 -0.8 0.9
Prospective memory result 0.2 0.3 0.5 -0.7 0.2
Lung cancer (father) 0.3 0.3 0.5 -0.4 0.7
Illnesses of mother 1.5 1.8 3.3 1.8 -0.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.1 0.2 0.4 0.2 -0.6
Pulse wave Arterial Stiffness index 2.0 2.3 2.6 -1.4 1.6
Impedance of arm (left) 3.1 14.6 18.6 -3.2 4.3
Arm fat mass (right) 0.1 0.2 0.4 0.3 -0.6
Trunk predicted mass 4.5 25.7 27.0 4.9 -5.2
Standing height 2.3 22.6 27.7 5.3 -4.2
Length of working week for main job 0.3 0.3 0.4 0.4 0.6
Exposure to tobacco smoke at home 0.4 0.4 0.8 -0.9 0.1
Breastfed as a baby 0.4 0.5 0.6 -0.8 0.6
Tense / ‘highly strung’ 0.0 0.1 0.1 0.1 -0.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.4 0.6 1.3 -1.1 0.1
Hair/balding pattern: Pattern 4 0.8 1.9 2.8 1.7 -1.0
Birth weight of first child 1.2 2.1 3.6 1.9 -0.8
Peak expiratory flow (PEF) 0.9 2.0 2.5 -1.6 1.2
Pulse wave reflection index 0.2 0.3 0.4 -0.5 0.6
Ever highly irritable/argumentative for 2 days 0.4 0.5 0.5 -0.7 0.7
Loud music exposure frequency 0.5 0.6 0.8 -0.6 0.9
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 0.7 -0.2 0.9
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.2 -0.5 0.5
Blood clot in the leg (DVT) 0.5 0.6 0.7 -0.7 0.8
Medication: Paracetamol 0.2 0.4 0.4 -0.6 0.6
Headache pain in last month 0.6 1.1 1.6 -1.2 0.8
Medication for cholesterol, blood pressure or diabetes 1.2 1.9 2.6 1.6 -1.1
Glaucoma (self-reported) 0.2 0.2 0.3 0.2 0.6
Gout (self-reported) 1.6 2.2 2.6 -1.4 1.6
Hypothyroidism/myxoedema (self-reported) 1.3 2.6 4.0 -2.0 1.1
Medication: Amlodipine 0.2 0.3 0.5 0.3 -0.7
Medication: Ventolin 100micrograms inhaler 2.0 2.6 3.8 -1.2 2.0
Birth weight 3.0 6.6 7.5 2.7 -2.4
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.6 0.3 -0.7
High blood pressure (siblings) 4.1 6.0 9.1 -3.0 1.7
Forced vital capacity (FVC), Best measure 0.7 2.6 2.7 1.5 -1.7
Body fat percentage 0.3 1.1 1.2 -1.0 1.1
Leg fat percentage (right) 0.0 0.1 0.1 -0.3 0.1
Arm fat-free mass (right) 3.7 19.0 20.8 4.1 -4.6
Exposure to tobacco smoke outside home 1.2 1.6 3.1 -1.7 0.2
Comparative body size at age 10 0.4 1.1 1.6 0.8 -1.2
Number of full brothers 0.1 0.2 0.2 0.5 -0.3
Worry too long after embarrassment 0.9 1.5 2.5 -1.6 0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.5 0.7 0.4
Wheeze or whistling in the chest in last year 3.1 5.5 6.1 -2.2 2.5
Number of children fathered 0.6 0.7 1.3 0.0 1.1
Reason for reducing amount of alcohol drunk: Health precaution 2.9 3.4 5.8 1.0 -2.4
Age at first live birth 3.6 6.4 7.9 2.8 -2.2
Pulse wave peak to peak time 3.1 3.7 3.9 1.9 -2.0
Health satisfaction 4.4 5.8 7.2 -2.7 2.1
Shortness of breath walking on level ground 1.3 1.5 2.0 -1.0 1.4
Qualifications: College or University degree 0.2 0.6 0.9 1.0 -0.5
Eye problems/disorders: None of the above 0.0 0.0 0.1 -0.3 0.0
Mouth/teeth dental problems: Loose teeth 2.2 2.6 4.6 -0.8 2.1
Emphysema/chronic bronchitis 0.3 0.4 0.4 -0.7 0.6
Medication for pain relief, constipation, heartburn 1.4 2.5 2.7 1.7 -1.5
Neck or shoulder pain in last month 1.3 1.9 2.0 -1.4 1.3
Medication: Blood pressure 1.6 2.8 4.5 -2.1 1.1
Angina (self-reported) 7.4 9.7 10.0 -3.1 3.2
Migraine (self-reported) 3.2 4.0 5.3 -2.3 1.6
Medication: Ibuprofen 0.0 0.0 0.0 0.2 -0.1
Medication: Allopurinol 3.8 5.0 5.7 -2.4 2.1
Medication: Omeprazole 1.3 1.5 2.2 -1.5 0.9
Medication: Seretide 50 evohaler 0.3 0.4 0.6 0.8 -0.4
Mean time to correctly identify matches 1.9 3.6 4.5 -1.7 2.1
Heart disease (mother) 2.6 3.2 3.6 -1.7 1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.0 0.0 0.0 -0.1 -0.0
Whole body fat mass 0.1 0.3 0.4 0.7 -0.5
Leg fat mass (right) 0.1 0.5 0.5 0.7 -0.7
Arm predicted mass (right) 4.3 22.0 24.4 4.4 -4.9
Pulse rate, automated reading 4.9 15.8 20.8 -4.6 3.3
Alcohol intake frequency. 1.0 2.3 3.2 -1.2 1.8
Comparative height size at age 10 2.2 12.1 14.0 3.7 -3.2
Number of full sisters 0.2 0.2 0.4 -0.2 -0.6
Suffer from ‘nerves’ 0.3 0.5 1.0 -1.0 0.2
Overall health rating 10.1 21.7 22.0 -4.7 4.6
Chest pain or discomfort 3.2 4.6 6.3 -1.7 2.5
Had major operations 3.4 4.0 4.0 -2.0 2.0
Age at last live birth 1.9 2.7 2.9 1.7 -1.6
Family relationship satisfaction 0.2 0.3 0.5 -0.7 -0.1
Leg pain on walking 3.0 3.8 5.3 -1.5 2.3
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.3 -0.3 1.1
Commuting to job workplace: Car/motor vehicle 1.8 2.1 2.7 -1.6 1.2
Illness, injury, bereavement, stress in last 2 years 2.1 2.6 3.4 1.3 -1.9
Medication: Aspirin 2.9 3.9 5.2 -2.3 1.6
Supplements: Vitamin C 0.4 0.4 0.7 0.9 -0.3
Knee pain experienced in last month 1.4 2.2 3.2 -1.1 1.8
Hypertension (Self-reported) 1.8 5.0 6.9 -2.6 1.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.2 2.6 3.7 -1.9 1.2
Illnesses of father: Heart disease 0.5 0.7 1.1 -1.0 0.6
Illnesses of siblings: Diabetes 0.0 0.1 0.1 -0.0 -0.3
Smoking status: Previous 0.6 0.9 1.2 -1.1 0.8
Forced expiratory volume in 1-second (FEV1), predicted 2.2 4.5 4.9 2.2 -2.0
Whole body fat-free mass 3.5 19.8 20.3 4.4 -4.5
Leg fat-free mass (right) 2.0 10.7 11.5 3.4 -3.1
Arm fat percentage (left) 0.5 2.2 2.2 -1.5 1.5
Average weekly red wine intake 1.2 1.7 2.7 1.7 -0.8
Handedness (chirality/laterality): Left-handed 0.7 0.8 1.5 0.3 -1.2
Mood swings 0.2 0.4 0.7 -0.1 0.9
Loneliness, isolation 0.0 0.0 0.0 0.1 0.2
Long-standing illness, disability or infirmity 1.0 1.5 1.6 -1.2 1.3
Ever had bowel cancer screening 1.1 1.2 1.4 1.0 -1.2
Diabetes diagnosed by doctor 0.0 0.0 0.1 -0.1 0.3
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.4 -0.1 0.6
Friendships satisfaction 1.3 1.6 2.6 -1.6 0.8
Qualifications: nursing, teaching 0.6 0.9 1.3 1.1 -0.8
Commuting to job workplace: Walk 0.9 1.0 1.8 -0.5 1.3
Eye problems/disorders: Cataract 0.0 0.1 0.1 0.3 0.2
Mouth/teeth dental problems: Mouth ulcers 0.3 0.4 0.7 0.8 -0.3
Medication for cholesterol 0.8 1.1 2.2 1.5 -0.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 0.9 1.3 -1.1 0.7
Back pain experienced in last month 0.1 0.1 0.2 -0.4 0.4
Mineral and other dietary supplements 1.0 1.4 1.4 1.2 -1.2
Breast cancer (self-reported) 0.8 1.0 1.0 -1.0 1.0
Asthma (self-reported) 0.5 0.9 1.3 -0.7 1.1
Osteoporosis (self-reported) 0.5 0.6 1.2 -0.2 1.1
Osteoarthritis (self-reported) 0.0 0.1 0.1 -0.3 -0.2
Medication: Aspirin 3.5 4.6 6.6 -2.6 1.6
Medication: Gliclazide 2.7 3.0 4.2 -1.4 2.1
Illnesses of father: None of the above (group 1) 1.1 1.4 2.5 1.6 -0.5
Smoking status: Current 0.2 0.4 0.4 0.5 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.6 1.9 -1.4 1.2
Whole body water mass 3.5 20.0 20.5 4.4 -4.5
Leg predicted mass (right) 2.0 10.6 11.6 3.4 -3.1
Arm fat mass (left) 0.0 0.2 0.2 0.4 -0.5
Number of self-reported non-cancer illnesses 4.4 7.6 8.6 -2.6 2.9
Average weekly champagne plus white wine intake 1.9 2.6 3.2 1.8 -1.4
Miserableness 0.2 0.4 0.4 -0.6 0.6
Guilty feelings 1.4 2.1 3.2 -1.8 1.0
Wears glasses or contact lenses 0.0 0.1 0.1 -0.3 0.2
Ever taken oral contraceptive pill 0.3 0.4 0.6 0.8 0.4
Hearing aid user 0.6 0.7 1.2 -1.1 0.3
Mother’s age at death 3.1 3.9 7.0 2.6 -0.9
Financial situation satisfaction 9.0 11.1 13.4 -3.7 3.0
Tinnitus: Yes, now most or all of the time 0.4 0.5 0.9 -0.9 0.4
Commuting to job workplace: Public transport 3.5 4.1 5.1 1.8 -2.3
Eye problems/disorders: Glaucoma 0.2 0.3 0.4 -0.4 0.6
Medication: Blood pressure 0.5 0.9 1.4 -1.2 0.7
Pain type(s) experienced in last month: Hip pain 0.6 0.7 1.2 -0.5 1.1
Supplements: Fish oil (including cod liver oil) 3.9 5.1 5.5 -2.3 2.2
High cholesterol (Self-reported) 3.1 5.5 5.9 -2.4 2.2
Medication: Bendroflumethiazide 0.0 0.0 0.0 0.0 0.0
Medication: Paracetamol 0.8 1.2 1.8 -1.4 0.8
Medication: Lisinopril 0.1 0.2 0.2 -0.3 0.5
Medication: Atorvastatin 3.5 4.3 4.8 -2.2 2.0
Illnesses of father: High blood pressure 0.9 1.2 1.9 -0.6 -1.4
Alcohol drinker status: Never 0.3 0.3 0.5 -0.7 0.3
Ever smoked 0.8 1.4 1.8 -1.0 1.4
Basal metabolic rate 3.1 17.1 17.5 4.1 -4.2
Leg fat percentage (left) 0.0 0.0 0.0 0.1 -0.1
Arm fat-free mass (left) 3.7 19.0 20.7 4.2 -4.5
Number of operations (self-reported) 2.3 3.4 3.5 -1.9 1.8
Average weekly beer plus cider intake 0.4 0.5 0.6 -0.8 0.7
Irritability 2.0 3.4 3.5 -1.9 1.8
Risk taking 1.2 1.8 2.6 1.6 -1.0
Ever had prostate specific antigen (PSA) test 0.8 0.9 0.9 1.0 -0.9
Fractured/broken bones in last 5 years 0.9 1.2 1.8 1.3 -0.7
Age started oral contraceptive pill 0.3 0.4 0.7 0.9 -0.1
Diastolic blood pressure, automated reading 0.6 1.9 3.1 -1.7 0.9
Ever depressed for a whole week 0.8 1.0 1.6 0.6 -1.3
Unable to work because of sickness or disability 5.4 7.0 7.2 -2.7 2.6
Commuting to job workplace: Cycle 4.8 5.8 7.3 2.7 -2.1
Myopia 0.7 1.0 1.0 1.0 -1.0
Vascular/heart problems diagnosed by doctor 2.2 5.9 7.9 2.8 -2.0
Cholesterol lowering medication 1.2 1.7 2.6 -1.6 1.0
Medication: Omeprazole (e.g. Zanprol) 1.8 2.2 2.5 -1.3 1.6
Pain experienced in last month 2.5 4.2 4.9 1.9 -2.2
Supplements: Calcium 0.0 0.0 0.0 0.1 0.0
Basal cell carcinoma (self-reported) 3.5 4.2 5.3 1.7 -2.3
Heart attack/myocardial infarction (self-reported) 1.5 2.0 2.0 -1.4 1.4
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.4 -0.6 0.6
Heart disease (siblings) 5.0 6.2 7.5 -2.2 2.7
Alcohol drinker status: Previous 0.2 0.3 0.3 -0.4 0.6
Pack years of smoking 0.6 0.8 1.0 -1.0 0.8
Impedance of whole body 1.6 8.1 11.0 -2.3 3.3
Leg fat mass (left) 0.2 0.8 0.8 0.9 -0.9
Arm predicted mass (left) 4.2 21.5 22.7 4.5 -4.8