Hub : Genes

SLC11A1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0663	0.0329	1.0e-03	0.069	0.019	0.072	0.056	0.068	1.5e-10	6.6e-04	7.0e-11	8.8e-09	1.9e-10
2	NTR	Blood	0.0710	0.0267	6.0e-04	0.031	0.008	0.019	0.031	0.028	2.6e-10	1.2e-03	6.0e-07	1.8e-10	1.8e-09
3	YFS	Blood	0.5211	0.0392	0.0e+00	0.167	0.226	0.258	0.252	0.263	3.3e-52	2.6e-72	4.0e-84	1.2e-81	5.1e-86
4	TCGA	Breast Invasive Carcinoma	0.0185	0.0096	5.3e-04	0.023	0.007	0.014	NA	0.022	1.4e-05	8.9e-03	6.6e-04	NA	2.2e-05
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0286	0.0161	2.8e-03	0.013	0.023	0.020	NA	0.018	1.1e-02	1.1e-03	2.1e-03	NA	3.2e-03
6	TCGA	Lung Adenocarcinoma	0.0297	0.0160	1.6e-03	0.029	0.031	0.028	NA	0.028	2.4e-04	1.4e-04	2.6e-04	NA	2.5e-04
7	TCGA	Lung Squamous Cell Carcinoma	0.0601	0.0263	1.6e-05	0.014	0.040	0.032	NA	0.033	7.9e-03	2.2e-05	1.3e-04	NA	1.2e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.1	0.1	0.5	0.7	0.1	0.4	-0.3	0.4	-0.2	0.2
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	-0.4	-0.7	-0.4	-0.2	0.3	0.4	0.0
Depressed Affect (Nagel 2018)	0.4	0.8	2.8	-0.4	-0.7	-1.7	-1.1	-0.6	0.0	-0.5
Depression (Nagel 2018)	0.2	0.2	0.5	0.1	0.1	-0.5	-0.7	-0.2	0.7	-0.7
Intelligence (Savage-Jansen 2018)	0.4	1.3	2.8	1.2	1.7	1.0	-0.1	-1.3	-0.9	-1.1
Neuroticism (Nagel 2018)	0.4	1.0	2.1	0.6	0.3	-1.0	-1.3	-1.2	-0.5	-1.5
Schizophrenia (2018)	0.2	0.5	1.2	-1.1	-1.1	-0.9	-0.0	0.0	0.7	-0.2
Schizophrenia vs Biploar Disorder	1.5	2.0	5.0	-2.0	-2.2	-1.9	0.4	0.3	0.8	-0.6
Worry (Nagel 2018)	0.8	1.6	2.8	1.3	1.1	-0.6	-1.7	-1.5	-0.9	-1.7
Alzheimer’s Disease (in mother)	1.2	1.5	5.1	0.5	0.5	0.1	-0.8	-1.8	-0.8	-2.3
Alzheimer’s Disease (in father)	4.3	4.6	12.0	-3.2	-3.5	-2.9	0.8	0.6	0.6	0.8
Alzheimer’s Disease (including proxy)	1.0	1.4	3.1	-1.8	-1.7	-0.9	1.4	-0.0	0.8	-0.6
Crohns Disease (2017)	2.0	4.3	7.4	-0.4	-1.3	1.5	2.7	2.7	2.4	2.5
Irritable Bowel Disease (IBD)	1.4	3.2	5.9	0.9	-0.5	2.2	2.0	2.4	1.8	1.8
Ulcerative Colitis (UC)	0.5	1.0	2.5	1.6	0.3	1.6	0.4	1.1	0.5	0.6
Major Depression (MDD)	0.8	1.0	2.5	-1.6	-1.3	0.0	0.0	0.8	1.4	0.7
Reaction Time	0.2	0.4	1.1	0.3	0.7	0.4	0.1	0.8	0.2	1.0
Verbal and Numeric Reasoning (VNR)	0.7	1.6	4.8	0.5	0.8	-0.1	-0.5	-2.2	-1.1	-2.0
Breast Cancer	0.3	0.6	2.0	0.9	0.3	1.4	0.8	0.8	0.5	0.1
Ovarian Cancer	1.6	2.1	5.1	-0.9	-0.8	-0.1	1.4	2.0	1.5	2.3
Prostate Cancer	0.1	0.1	0.4	0.1	0.7	-0.1	0.2	0.4	-0.0	0.6
Age at First Birth	0.7	1.1	3.6	-0.1	0.4	-0.1	0.2	1.5	1.2	1.9
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	-0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	4.8	6.6	15.3	-0.7	-0.3	1.6	2.6	3.3	3.9	3.1
Coronary Artery Disease (CAD)	0.5	0.6	1.9	-1.4	-0.7	-0.4	0.9	0.7	0.5	0.6
Crohns Disease (2012)	1.4	2.2	5.9	0.8	-0.6	1.2	2.4	1.7	1.3	1.6
Mean Putamen Volume	2.5	2.9	7.0	0.9	1.8	2.6	2.0	1.4	1.0	1.5
Fasting Glucose	0.5	0.6	2.0	1.4	0.2	0.5	-0.3	0.3	-0.8	1.2
HbA1C	0.9	1.0	2.9	-0.1	0.3	0.3	1.0	1.4	0.8	1.7
HDL Cholesterol	0.3	0.4	1.9	0.2	-0.2	-0.6	-1.4	-0.8	-0.2	-0.0
LDL Cholesterol	0.2	0.4	1.0	0.5	0.2	0.6	-0.7	-0.5	-1.0	-0.1
Lupus	0.7	1.0	2.6	1.6	1.3	0.6	-0.7	0.2	-0.6	1.3
Neuroticism (2016)	0.6	0.8	2.9	-0.7	-0.2	-0.8	-0.6	-1.1	0.0	-1.7
Primary Biliary Cirrhosis	0.9	1.3	2.9	1.7	1.1	1.3	0.1	-1.1	-1.0	-1.1
Rheumatoid Arthritis	0.4	0.6	1.9	0.2	0.6	-0.2	-0.5	-1.1	-1.4	-0.1
Schizophrenia (2014)	0.3	0.6	1.3	-1.1	-1.1	-1.0	-0.5	-0.3	0.5	-0.7
Triglycerides	0.4	0.7	1.4	0.7	1.2	0.9	0.6	-0.0	-0.6	-1.2
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.5	-0.6	-0.6	0.0	0.7	0.4	0.7	-0.4
Ulcerative Colitis	1.0	1.4	2.6	0.9	-0.3	1.5	1.3	1.6	1.1	1.1
Blood Eosinophil Count	0.5	3.7	6.6	2.6	2.2	1.1	-1.1	-2.4	-2.1	-1.4
Blood Platelet Count	8.5	99.0	237.2	-0.4	-1.1	6.8	8.8	15.4	13.6	12.1
Blood Red Count	4.6	44.9	104.9	1.4	2.0	-2.6	-4.7	-9.7	-8.9	-10.2
Blood White Count	0.4	2.9	11.6	1.4	3.4	0.5	-0.8	-1.5	-1.8	0.6
Heel T-Score	0.1	0.9	1.8	1.1	0.4	1.3	-1.0	0.5	-0.8	1.1
BMI	2.6	15.0	36.6	-2.3	-2.2	0.4	4.0	4.9	6.0	4.3
Height	7.2	138.3	299.3	-1.1	3.1	-7.8	-9.7	-17.3	-15.4	-16.3
Waist Hip Ratio (WHR)	0.2	0.7	1.8	1.0	-0.0	1.3	1.2	0.6	-0.6	0.5
Systolic Blood Pressure	0.9	4.3	10.7	-0.7	-0.6	1.2	2.7	3.3	2.1	2.4
Smoking Status	0.1	0.2	0.3	0.5	0.2	0.4	0.4	0.5	0.6	0.5
Allergy or Eczema	3.8	10.0	18.7	0.6	0.4	3.1	3.1	4.0	4.3	3.9
Cardiovascular Disease	1.2	4.1	9.1	-0.1	1.3	1.7	1.8	3.0	2.6	2.2
Hypothyroidism (self reported)	3.0	6.9	12.4	0.7	1.4	2.3	2.3	3.3	3.5	3.5
Respiratory disease	2.5	5.5	11.2	-0.0	-0.5	1.7	3.0	3.3	2.5	3.1
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.1	0.7	0.7	1.4	0.9	1.2	0.7	1.4
Lung FEV1/FVC ratio	0.2	0.9	2.2	0.4	0.8	1.0	0.6	0.9	1.5	1.0
Lung FVC	0.3	1.6	4.6	1.3	0.5	-0.3	-1.9	0.9	-0.7	2.1
Neuroticism	0.9	2.3	3.7	1.2	1.3	-0.4	-1.9	-1.9	-1.2	-1.9
Chronotype (morning person)	0.6	1.3	3.3	0.3	0.2	-0.3	-0.6	-1.5	-1.7	-1.8
Hair Pigment	0.0	0.2	0.5	-0.4	-0.4	-0.7	-0.1	0.4	0.7	0.4
Tanning	0.1	0.8	3.0	0.4	-0.1	-0.3	-1.3	0.7	-0.0	1.7
Hand grip strength (left)	3.0	8.0	16.7	0.4	1.1	-1.8	-3.4	-4.1	-3.5	-3.3
Number of treatments/medications taken	1.4	2.5	6.3	-0.5	0.1	0.9	1.7	2.2	2.5	1.6
Average weekly spirits intake	0.8	0.9	2.8	0.7	0.8	0.9	0.3	1.1	0.6	1.7
Sensitivity / hurt feelings	0.2	0.4	0.9	0.1	-0.7	-0.7	0.4	0.2	0.7	-1.0
Frequency of depressed mood in last 2 weeks	0.9	1.3	2.6	1.5	1.3	0.4	-1.2	-0.9	-0.2	-1.6
Hearing difficulty/problems: Yes	0.5	0.8	3.5	-0.2	0.2	-1.1	-1.9	-0.7	-0.5	-0.3
Relative age of first facial hair	1.0	2.1	5.3	-1.0	-1.2	0.7	1.5	1.5	2.3	1.3
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.8	0.1	0.4	-0.3	0.3	0.4	0.9	0.1
Ever used hormone-replacement therapy (HRT)	1.6	2.0	3.8	1.1	-0.2	-0.9	-1.9	-1.6	-1.7	-1.7
Ever had hysterectomy (womb removed)	1.4	1.6	3.3	-1.1	-1.5	-1.8	-0.8	-1.1	-1.3	-1.1
Systolic blood pressure, automated reading	1.9	5.6	12.4	-1.2	-1.9	0.3	2.6	3.5	2.7	2.7
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.4	1.0	0.2	1.4	0.2	0.7	0.5	1.6
Angina	0.4	0.6	1.5	-0.4	-0.2	0.2	1.2	1.1	0.4	0.9
Medication for hormone replacement therapy	0.5	0.5	1.3	-0.3	-0.8	-1.1	-1.0	0.5	-0.4	0.5
Vitamin and mineral supplements	1.1	1.4	4.0	2.0	1.8	1.1	-0.8	-0.4	-0.9	0.3
Supplements: Zinc	0.3	0.4	1.1	-1.0	-0.3	0.3	0.4	0.1	0.1	-1.0
Medication: Co-codamol	0.8	1.0	2.5	0.3	-0.2	0.5	0.8	1.6	1.1	1.4
Medication: Metformin	1.2	1.7	4.0	1.4	0.7	2.0	1.1	1.0	1.1	1.4
Diabetes (father)	0.3	0.4	1.3	0.2	-0.9	0.2	0.4	1.1	0.5	-0.1
Diabetes (mother)	0.6	0.8	2.0	-1.4	-0.5	-0.6	0.5	1.1	1.3	-0.0
Severe depression (siblings)	2.2	2.5	6.1	-2.5	-2.3	-1.8	1.1	0.5	0.8	-0.7
Pack years adult smoking proportion	0.3	0.5	1.5	-0.1	-0.7	-1.2	-0.7	-0.5	-0.3	-0.9
Impedance of leg (right)	2.4	11.7	24.6	0.5	-0.7	-2.0	-2.5	-4.9	-4.7	-5.0
Leg fat-free mass (left)	0.1	0.7	2.2	-1.5	0.7	-0.7	0.2	-1.1	0.0	-0.8
Trunk fat percentage	1.6	6.2	14.5	-2.5	-2.0	0.2	3.7	2.1	3.8	0.9
Hand grip strength (right)	2.9	7.8	15.8	0.8	0.9	-1.5	-3.1	-4.0	-3.9	-3.2
Townsend deprivation index at recruitment	1.2	1.7	4.3	0.5	0.7	1.3	0.4	1.9	1.1	2.1
Current tobacco smoking	0.1	0.1	0.4	0.6	-0.2	-0.3	-0.6	-0.2	0.2	-0.3
Average weekly fortified wine intake	1.0	1.1	3.5	1.0	1.8	1.9	-0.3	-0.1	0.2	0.2
Maternal smoking around birth	0.2	0.3	1.1	-0.6	-0.0	-0.8	0.1	-0.0	1.0	-0.5
Fed-up feelings	0.4	0.7	1.6	0.2	-0.7	-1.0	-1.3	-0.6	-0.9	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.5	0.6	2.0	-0.6	-0.6	-1.0	-0.6	0.0	1.4	-0.7
Relative age voice broke	0.7	1.0	2.9	-0.9	-1.7	-0.2	0.4	1.1	1.4	0.3
Taking other prescription medications	2.1	3.3	6.9	0.3	0.8	1.5	1.3	2.5	2.4	2.6
Age when periods started (menarche)	0.2	0.5	1.0	-1.0	-1.0	-0.7	-0.0	0.6	0.1	0.8
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	-0.4	-0.1	-0.2	0.1	0.2	-0.2	0.3
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.2	7.1	1.7	2.1	2.7	-0.1	-0.2	0.0	-0.8
Tinnitus: Yes, but not now, but have in the past	5.0	5.3	10.1	-3.2	-2.6	-1.3	2.7	2.3	1.7	1.9
Qualifications: CSEs or equivalent	0.0	0.1	0.2	-0.2	-0.4	0.4	-0.0	-0.1	-0.3	0.0
Serious illness, injury or assault to yourself	0.6	0.7	2.1	-1.5	-0.7	-0.6	0.1	0.8	0.6	1.1
High blood pressure	2.8	7.8	17.2	-0.6	1.1	1.6	3.0	4.2	3.5	3.4
Hayfever, allergic rhinitis or eczema	2.7	6.0	10.0	0.5	0.4	2.5	2.5	3.2	3.1	3.1
Multivitamins +/- minerals	1.6	2.0	5.2	-2.3	-2.3	-1.6	0.2	-0.3	0.3	-0.9
Stomach or abdominal pain in last month	0.7	0.9	2.3	-1.4	-1.5	-0.6	0.0	0.5	1.0	0.6
Supplements: Glucosamine	0.8	1.1	1.8	-1.2	-1.3	-1.3	-0.4	-1.1	-0.1	-1.2
Diverticular disease/diverticulitis (self-reported)	1.2	1.4	4.3	-0.3	-0.4	0.6	2.1	1.3	1.4	1.1
Medication: Atenolol	0.9	1.1	3.5	0.2	1.3	-0.5	-1.9	-0.8	-1.0	-0.6
Medication: Levothyroxine sodium	1.2	2.1	5.6	0.7	1.3	1.1	0.7	2.0	1.0	2.4
Sitting height	4.5	31.9	65.8	-0.9	1.9	-3.9	-5.7	-8.1	-7.0	-7.6
Chronic bronchitis/emphysema (father)	0.0	0.0	0.1	0.2	0.4	0.3	-0.0	-0.2	-0.1	-0.1
High blood pressure (mother)	0.8	1.1	2.4	-1.2	-0.3	-0.0	0.6	1.5	1.6	1.1
Body mass index (BMI)	3.5	14.7	33.1	-2.2	-1.6	1.1	4.4	4.9	5.8	4.2
Impedance of leg (left)	2.8	13.7	29.9	1.1	0.1	-1.8	-3.0	-5.3	-5.0	-5.5
Leg predicted mass (left)	0.1	0.7	2.0	-1.4	0.8	-0.7	0.1	-1.1	-0.0	-0.8
Trunk fat mass	0.7	3.1	6.7	-2.4	-1.4	-0.5	2.6	0.7	2.6	-0.1
Waist circumference	0.7	2.7	6.1	-1.7	-1.0	0.3	2.2	1.5	2.5	1.3
Number of incorrect matches in round	0.1	0.1	0.2	0.1	0.4	0.5	-0.4	0.1	-0.1	-0.3
Past tobacco smoking	0.3	0.5	0.9	-0.2	-0.5	-0.8	-0.7	-0.9	-1.0	-0.5
Alcohol usually taken with meals	1.9	3.1	7.2	0.9	1.2	-0.1	-1.5	-2.7	-1.9	-2.4
Nervous feelings	0.4	0.7	1.9	-0.0	-0.6	-1.4	-1.0	-0.9	-0.2	-1.1
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	2.3	1.0	1.1	-0.3	-1.3	-0.9	-0.6	-1.5
Hearing difficulty/problems with background noise	1.7	2.7	6.7	-0.1	0.0	-1.6	-2.0	-2.1	-1.0	-2.6
Hair/balding pattern: Pattern 2	0.4	0.5	1.2	-0.7	-1.1	0.2	1.0	0.6	0.6	0.2
Had menopause	1.8	2.2	7.7	-1.8	-2.8	-2.1	0.5	0.0	0.0	-0.2
Had other major operations	0.1	0.1	0.3	-0.1	0.1	-0.5	-0.4	-0.5	-0.4	0.0
Forced vital capacity (FVC)	3.3	12.7	26.8	1.1	2.1	-2.0	-4.5	-4.5	-5.2	-3.5
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	4.1	1.1	1.9	2.0	-0.4	-0.2	-0.1	-0.7
Ever unenthusiastic/disinterested for a whole week	1.6	1.9	4.1	-0.5	0.1	-1.3	-2.0	-1.8	-1.2	-1.7
Qualifications: None of the above	2.4	5.2	11.2	1.4	0.7	1.9	1.0	2.8	3.4	3.2
Financial difficulties in last 2 years	0.5	0.7	1.9	-0.1	0.2	-0.6	-1.2	-1.0	-0.6	-1.4
Mouth/teeth dental problems	2.3	3.5	10.2	1.2	0.5	-0.5	0.4	-2.5	-2.4	-3.2
Heart attack	0.1	0.2	0.5	-0.2	0.7	0.1	-0.4	0.7	0.2	-0.1
Allergy	2.6	6.0	11.2	-0.9	-0.5	-2.5	-2.0	-3.3	-2.9	-3.3
Pain all over the body in last month	0.2	0.2	0.4	-0.1	-0.1	0.3	0.6	0.5	0.4	0.5
Diabetes (self-reported)	1.1	1.6	5.4	0.8	0.3	1.4	0.7	1.7	0.6	2.3
Hayfever/allergic rhinitis (self-reported)	3.1	4.1	8.4	0.7	0.6	2.3	1.7	2.9	2.2	2.5
Medication: Ramipril	5.1	6.5	15.1	-1.2	-0.8	1.6	3.9	3.3	3.0	2.4
Medication: Simvastatin	2.1	3.0	7.4	-0.5	-0.1	1.0	2.2	2.7	1.3	2.4
Fluid intelligence score	0.8	1.6	4.5	0.6	0.9	0.1	-1.0	-2.1	-1.3	-1.6
Illnesses of siblings	0.3	0.5	1.0	0.6	0.4	0.7	-0.4	0.9	0.6	1.0
Neuroticism score	1.6	3.2	7.5	0.3	0.3	-1.4	-2.6	-2.3	-1.1	-2.7
Weight	0.2	1.2	4.5	-2.1	-0.4	-1.0	1.1	-0.5	0.9	-0.6
Impedance of arm (right)	0.3	1.3	4.6	0.5	-0.1	0.4	-0.1	-1.5	-1.2	-2.1
Arm fat percentage (right)	3.6	14.3	32.6	-2.5	-1.9	1.3	4.9	4.5	5.7	3.5
Trunk fat-free mass	1.7	9.6	22.8	-0.4	2.3	-1.9	-2.9	-4.8	-3.9	-3.3
Hip circumference	0.3	1.2	4.6	-2.1	-0.2	-0.4	1.1	-0.1	1.5	-0.1
Time employed in main current job	1.9	2.2	5.4	2.1	2.3	1.5	-1.0	0.0	-0.6	1.3
Alcohol intake versus 10 years previously	2.0	3.0	5.4	-1.4	-1.4	0.0	2.0	2.3	1.4	2.3
Father’s age at death	0.2	0.3	0.9	0.1	0.1	0.2	-1.0	0.1	-0.6	0.9
Worrier / anxious feelings	0.1	0.2	0.6	-0.4	-0.3	-0.3	0.5	-0.2	0.1	-0.8
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	1.0	0.1	0.4	-0.0	0.2	-0.2	0.4	-1.0
Falls in the last year	0.8	1.1	2.0	0.1	0.3	1.2	1.2	1.1	1.4	1.2
Hair/balding pattern: Pattern 3	2.4	3.6	8.0	2.5	2.8	1.2	-1.6	-1.6	-1.8	-1.2
Number of live births	0.3	0.4	0.8	0.9	0.6	0.9	-0.5	-0.4	-0.4	0.2
Forced expiratory volume in 1-second (FEV1)	2.4	8.1	16.1	1.4	2.3	-1.0	-3.6	-3.4	-4.0	-2.6
Pulse rate	0.1	0.1	0.3	-0.3	-0.2	-0.1	0.3	-0.0	-0.6	-0.2
Happiness	2.9	3.5	7.4	1.0	1.4	-0.4	-2.7	-2.1	-1.6	-2.6
Noisy workplace	1.1	1.4	4.8	-0.5	-0.1	0.5	0.3	1.6	1.2	2.2
Qualifications: A levels/AS levels or equivalent	3.9	8.5	16.6	1.1	2.2	-0.1	-2.8	-4.1	-3.9	-3.7
Serious illness, injury or assault of a close relative in last 2 years	2.2	2.5	5.3	-1.4	-1.3	-0.1	1.6	1.8	2.3	1.6
Mouth/teeth dental problems: Dentures	2.0	3.3	9.4	0.1	1.0	1.5	-0.1	2.4	2.2	3.1
Asthma	0.8	1.6	4.2	-0.1	-0.6	0.7	1.4	2.0	1.3	1.6
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	1.3	-0.1	0.7	0.4	1.1	0.5	0.8	-1.0
Medication: Cholesterol lowering	0.4	0.6	1.2	-0.2	0.1	0.9	1.0	1.1	1.1	-0.2
Depression (self-reported)	1.6	1.9	4.7	-1.0	-1.2	-1.4	-1.2	-1.5	-0.7	-2.2
Medication: Lansoprazole	0.4	0.5	1.8	-0.8	-0.2	0.1	1.4	0.1	0.7	-0.3
Prospective memory result	0.5	0.6	2.0	-1.0	-1.4	-1.0	0.5	0.4	0.1	0.5
Lung cancer (father)	0.3	0.3	0.7	-0.2	-0.6	-0.6	0.3	0.8	0.6	0.7
Illnesses of mother	1.7	2.1	5.3	1.1	-0.2	-0.3	-1.3	-2.3	-2.2	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	2.0	6.3	12.7	1.8	2.4	-0.4	-3.2	-3.0	-3.6	-1.9
Pulse wave Arterial Stiffness index	0.6	0.7	1.1	-1.1	-0.9	-0.9	0.8	-0.5	-0.8	-1.0
Impedance of arm (left)	0.3	1.3	4.5	0.5	-0.3	0.3	-0.3	-1.4	-1.5	-2.1
Arm fat mass (right)	2.0	8.3	19.4	-2.5	-1.4	0.5	3.8	3.2	4.4	2.5
Trunk predicted mass	1.7	9.7	23.0	-0.4	2.3	-1.9	-2.9	-4.8	-4.0	-3.4
Standing height	5.8	57.1	127.7	0.1	2.7	-4.5	-6.7	-11.3	-10.0	-10.0
Length of working week for main job	0.5	0.6	1.1	-1.0	-0.6	-1.0	0.3	0.6	1.0	-0.0
Exposure to tobacco smoke at home	0.5	0.5	1.8	-1.4	-0.8	-0.6	-0.1	-0.1	0.9	0.0
Breastfed as a baby	1.0	1.2	3.3	1.4	1.8	1.4	0.4	-0.8	-0.6	-0.3
Tense / ‘highly strung’	1.4	2.3	5.3	-0.6	0.2	-1.7	-2.3	-1.8	-0.8	-2.0
Seen doctor (GP) for nerves, anxiety, tension or depression	2.6	4.0	10.4	-2.4	-2.1	-3.2	-1.1	-1.0	-0.2	-2.2
Hair/balding pattern: Pattern 4	0.1	0.3	1.2	1.1	0.6	0.1	-0.1	-0.8	-0.1	0.4
Birth weight of first child	0.3	0.6	1.4	-0.6	-0.4	-1.2	-0.8	-1.0	-0.8	0.0
Peak expiratory flow (PEF)	1.4	3.1	7.6	0.7	1.5	-0.9	-2.7	-1.9	-2.6	-0.9
Pulse wave reflection index	2.6	3.2	6.3	0.3	0.7	-1.2	-1.5	-2.5	-2.4	-2.5
Ever highly irritable/argumentative for 2 days	0.4	0.4	1.3	0.0	0.0	0.5	0.6	1.0	0.4	1.2
Loud music exposure frequency	0.6	0.7	3.9	-2.0	-0.4	-0.6	0.1	0.1	0.1	-0.4
Qualifications: O levels/GCSEs or equivalent	2.5	3.9	9.2	0.9	1.6	-0.1	-1.8	-2.4	-3.0	-2.5
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	1.3	-0.7	-0.4	-0.2	-1.1	-0.2	0.4	-0.0
Blood clot in the leg (DVT)	1.0	1.3	3.8	1.1	1.6	1.9	-0.0	0.4	0.6	1.1
Medication: Paracetamol	1.6	2.6	5.4	0.7	1.0	-1.3	-2.1	-2.2	-1.0	-2.3
Headache pain in last month	0.3	0.6	1.9	-0.3	0.2	-0.3	-0.5	-1.0	0.8	-1.4
Medication for cholesterol, blood pressure or diabetes	0.8	1.4	4.0	0.3	-0.1	-0.9	-1.3	-1.7	-2.0	-0.4
Glaucoma (self-reported)	0.7	0.8	1.9	0.8	1.2	0.5	-1.4	-0.7	-1.0	-0.2
Gout (self-reported)	1.2	1.7	3.9	-1.1	-0.9	-0.6	0.9	2.0	1.3	1.8
Hypothyroidism/myxoedema (self-reported)	2.0	3.8	10.6	0.9	1.4	1.7	0.8	2.5	1.9	3.2
Medication: Amlodipine	2.1	3.0	7.5	-1.0	-0.0	0.5	1.1	2.7	2.1	2.6
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.9	-1.0	-0.8	-0.3	0.6	0.2	1.4	-0.2
Birth weight	0.8	1.7	5.1	-0.9	-1.6	-2.3	-0.2	-1.1	-1.3	-0.6
Chronic bronchitis/emphysema (mother)	1.1	1.2	2.9	-0.7	-0.6	0.2	1.0	1.7	1.6	1.2
High blood pressure (siblings)	0.3	0.4	1.0	-1.0	-0.3	-0.7	0.2	-0.7	-0.4	-0.7
Forced vital capacity (FVC), Best measure	2.8	10.4	22.8	1.6	2.0	-1.6	-4.1	-4.0	-4.8	-2.8
Body fat percentage	2.0	8.0	18.7	-2.6	-2.3	0.3	4.0	2.7	4.3	1.4
Leg fat percentage (right)	1.8	6.6	14.3	-2.2	-2.5	0.0	3.4	2.6	3.8	1.8
Arm fat-free mass (right)	1.1	5.9	14.1	-0.7	1.2	-2.0	-2.1	-3.8	-2.9	-2.8
Exposure to tobacco smoke outside home	0.7	1.0	2.7	-0.7	-0.4	0.2	1.6	0.7	1.5	0.7
Comparative body size at age 10	1.5	4.2	13.0	-0.9	-0.6	-0.3	0.8	3.0	2.5	3.6
Number of full brothers	0.2	0.3	0.8	-0.9	-0.6	-0.3	0.4	-0.2	0.2	-0.7
Worry too long after embarrassment	1.1	1.9	9.0	0.1	0.0	-0.2	-0.2	-1.9	-0.8	-3.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.7	-0.7	-0.7	-1.6	-1.3	-0.2	-0.2	-0.4
Wheeze or whistling in the chest in last year	0.8	1.4	4.8	0.3	0.3	1.2	-0.0	1.3	2.2	1.1
Number of children fathered	0.3	0.4	1.0	-0.1	0.2	0.7	1.0	0.5	1.0	0.2
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.8	3.5	1.9	1.4	0.7	-1.1	-1.2	-1.5	-1.4
Age at first live birth	0.5	0.8	2.3	-0.7	-1.5	-0.7	1.3	-0.3	-0.8	-0.3
Pulse wave peak to peak time	0.5	0.6	2.3	1.0	0.9	0.3	-1.5	-0.3	0.1	0.2
Health satisfaction	0.3	0.4	1.6	-0.2	-0.1	-0.1	-0.3	-0.7	-0.7	-1.2
Shortness of breath walking on level ground	0.4	0.5	1.0	0.1	0.4	0.9	1.0	0.6	0.6	0.9
Qualifications: College or University degree	0.4	1.2	3.1	0.4	1.2	0.5	0.5	-1.5	-1.0	-1.8
Eye problems/disorders: None of the above	0.5	0.6	3.3	0.1	0.3	-0.4	0.1	-0.5	0.4	-1.8
Mouth/teeth dental problems: Loose teeth	2.3	2.7	4.7	-1.2	-0.6	-1.9	-2.1	-1.6	-1.4	-2.2
Emphysema/chronic bronchitis	0.9	1.0	3.0	1.5	0.6	1.7	1.0	0.1	0.6	0.3
Medication for pain relief, constipation, heartburn	0.1	0.2	0.6	0.2	-0.8	0.2	-0.1	-0.2	-0.6	0.5
Neck or shoulder pain in last month	1.9	2.7	6.4	-2.4	-2.3	-2.5	0.3	0.3	0.8	0.3
Medication: Blood pressure	2.1	3.7	9.1	-0.3	1.2	1.4	1.7	2.6	3.0	1.8
Angina (self-reported)	0.4	0.6	1.3	-0.7	-0.4	0.0	1.1	1.1	0.4	0.8
Migraine (self-reported)	0.2	0.2	0.4	0.6	0.3	0.1	0.5	0.5	0.4	-0.6
Medication: Ibuprofen	0.9	1.1	2.9	-0.3	0.3	0.5	1.7	1.3	1.5	-0.2
Medication: Allopurinol	0.6	0.8	2.4	-0.4	-0.7	-0.6	0.5	1.5	1.2	0.8
Medication: Omeprazole	0.8	1.0	2.1	0.6	0.7	0.2	-0.8	-1.2	-1.3	-1.5
Medication: Seretide 50 evohaler	0.1	0.1	0.3	0.1	-0.3	-0.0	-0.3	0.4	0.5	0.4
Mean time to correctly identify matches	0.3	0.5	1.4	0.6	0.5	0.8	0.3	0.8	0.3	1.2
Heart disease (mother)	1.4	1.7	3.8	-1.9	-0.2	-1.2	0.5	1.7	0.8	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.4	1.6	3.4	-0.3	-1.4	-0.1	1.6	1.8	1.5	1.1
Whole body fat mass	1.0	4.4	10.6	-2.4	-1.4	-0.1	3.0	1.5	3.2	0.8
Leg fat mass (right)	1.2	4.8	12.7	-2.2	-1.4	0.1	3.1	1.9	3.6	1.2
Arm predicted mass (right)	1.0	5.0	12.1	-0.8	1.1	-2.0	-1.8	-3.5	-2.6	-2.7
Pulse rate, automated reading	0.4	1.2	3.6	0.0	-0.4	-0.9	-0.6	-1.5	-1.1	-1.9
Alcohol intake frequency.	0.6	1.5	2.7	-1.3	-0.8	-1.4	0.2	1.6	1.6	0.8
Comparative height size at age 10	6.2	34.0	77.1	-0.0	2.2	-3.7	-5.5	-8.8	-7.7	-7.3
Number of full sisters	0.8	1.0	2.0	0.8	0.7	1.0	0.0	1.3	1.0	1.4
Suffer from ‘nerves’	0.6	0.9	2.4	-0.3	-0.6	-1.6	-1.4	-0.6	0.2	-1.1
Overall health rating	0.5	1.1	3.2	0.6	0.6	1.4	0.2	1.0	1.8	0.9
Chest pain or discomfort	0.6	0.8	2.6	-1.6	-0.8	-0.6	1.1	0.1	0.7	-0.6
Had major operations	0.4	0.4	0.8	0.4	0.9	0.8	0.2	-0.8	0.6	-0.3
Age at last live birth	0.2	0.2	0.5	0.3	-0.6	0.1	0.2	-0.5	-0.7	-0.7
Family relationship satisfaction	1.8	2.2	4.9	1.2	0.6	-0.3	-1.7	-1.8	-1.6	-2.2
Leg pain on walking	0.4	0.5	1.0	-1.0	-0.9	-0.4	0.7	0.6	0.1	0.7
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.4	3.6	-1.9	-1.6	-1.6	0.6	0.4	-0.5	0.1
Commuting to job workplace: Car/motor vehicle	0.5	0.6	2.1	-0.9	-1.0	-1.4	0.3	0.1	-0.0	-0.2
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	0.7	0.8	0.4	0.2	0.1	-0.7	-0.7	-0.7
Medication: Aspirin	0.8	1.0	2.1	-1.0	-0.5	-0.2	0.9	1.4	1.2	1.1
Supplements: Vitamin C	0.2	0.2	0.7	-0.8	-0.1	-0.0	0.8	-0.1	-0.1	0.4
Knee pain experienced in last month	0.5	0.7	1.7	-1.1	0.1	0.0	1.0	0.9	1.3	0.6
Hypertension (Self-reported)	2.8	7.7	16.2	-0.3	1.1	1.9	2.8	4.0	3.5	3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.5	-1.0	-1.0	0.1	1.2	1.2	1.2	0.1
Illnesses of father: Heart disease	0.3	0.4	0.7	-0.2	-0.2	-0.7	-0.0	-0.8	-0.9	-0.9
Illnesses of siblings: Diabetes	0.7	0.9	2.0	-0.2	0.1	0.9	1.2	1.4	1.3	-0.0
Smoking status: Previous	0.6	1.0	2.2	-0.1	0.2	0.8	1.0	1.5	1.3	1.1
Forced expiratory volume in 1-second (FEV1), predicted	4.0	8.2	16.3	0.7	1.8	-1.0	-3.2	-3.9	-4.0	-3.3
Whole body fat-free mass	0.8	4.7	11.8	-0.7	1.8	-1.5	-1.8	-3.4	-2.4	-2.5
Leg fat-free mass (right)	0.2	0.9	1.9	-0.9	1.3	-0.5	-0.3	-1.4	-0.3	-1.1
Arm fat percentage (left)	3.7	14.9	33.5	-2.3	-1.9	1.5	5.0	4.7	5.8	3.6
Average weekly red wine intake	3.3	4.8	11.1	3.3	3.3	1.8	-1.7	-1.8	-1.6	-0.4
Handedness (chirality/laterality): Left-handed	1.7	2.0	6.0	-2.4	-1.8	-1.9	0.5	-0.2	-1.1	0.1
Mood swings	0.3	0.5	1.2	-0.4	-0.5	-0.7	-0.8	-1.1	-0.2	-1.0
Loneliness, isolation	0.5	0.8	2.1	0.1	-0.7	-1.4	-1.2	-0.7	0.5	-0.8
Long-standing illness, disability or infirmity	1.6	2.5	5.2	-1.1	-1.1	-0.1	1.2	2.3	1.9	2.1
Ever had bowel cancer screening	0.7	0.9	2.2	-1.1	-1.5	-0.7	0.8	0.9	0.8	0.2
Diabetes diagnosed by doctor	1.2	2.0	3.9	0.9	0.4	1.7	1.2	1.8	1.1	2.0
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	1.9	0.7	1.1	1.4	-0.9	-1.1	-1.1	-1.2
Friendships satisfaction	2.0	2.4	5.7	1.4	0.5	-0.5	-2.4	-1.7	-2.2	-1.1
Qualifications: nursing, teaching	0.4	0.7	1.6	0.7	0.4	-0.1	-0.6	-1.2	-1.2	-0.8
Commuting to job workplace: Walk	1.2	1.3	2.2	1.3	1.1	1.1	-1.1	-1.2	-1.5	-0.6
Eye problems/disorders: Cataract	1.3	1.5	4.8	0.9	1.0	1.5	0.8	1.0	0.2	2.2
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	1.7	-0.7	-1.3	-0.4	0.5	1.0	0.9	1.0
Medication for cholesterol	2.0	3.0	7.2	0.6	0.2	-0.5	-1.5	-2.7	-2.2	-2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.5	1.8	4.3	-0.1	0.1	0.3	0.7	2.1	2.0	1.9
Back pain experienced in last month	0.8	1.2	2.7	-1.0	-1.6	-0.4	1.6	0.6	1.2	0.5
Mineral and other dietary supplements	1.2	1.6	4.0	1.1	0.9	1.4	0.8	1.4	0.8	2.0
Breast cancer (self-reported)	1.3	1.5	3.1	0.3	0.7	-0.5	-1.4	-1.8	-1.8	-1.2
Asthma (self-reported)	0.7	1.4	3.7	0.0	-0.5	0.7	1.3	1.9	1.2	1.5
Osteoporosis (self-reported)	0.5	0.6	2.6	0.6	-0.0	0.3	0.5	0.9	0.3	1.6
Osteoarthritis (self-reported)	0.8	1.0	3.2	-0.5	0.2	0.4	0.7	1.2	1.8	1.1
Medication: Aspirin	0.2	0.3	0.7	-0.9	-0.3	-0.5	0.1	0.6	0.5	0.4
Medication: Gliclazide	0.5	0.6	2.2	1.5	0.4	-0.0	-0.7	-0.3	-0.7	0.6
Illnesses of father: None of the above (group 1)	1.0	1.3	2.5	0.5	0.6	-0.3	-1.4	-1.6	-1.6	-1.2
Smoking status: Current	0.1	0.1	0.6	0.8	-0.1	-0.0	-0.3	0.1	0.4	-0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.5	0.6	0.8	1.2	0.4	0.6	-0.7	1.2
Whole body water mass	0.8	4.4	11.2	-0.6	1.8	-1.4	-1.8	-3.4	-2.4	-2.3
Leg predicted mass (right)	0.2	0.9	1.8	-1.0	1.2	-0.6	-0.3	-1.4	-0.3	-1.1
Arm fat mass (left)	1.9	7.9	18.8	-2.3	-1.4	0.5	3.7	3.1	4.3	2.5
Number of self-reported non-cancer illnesses	2.0	3.5	7.3	0.3	0.7	1.6	1.4	2.7	2.2	2.7
Average weekly champagne plus white wine intake	1.1	1.5	2.8	1.7	1.1	0.7	-1.2	-1.3	-0.8	-1.6
Miserableness	0.6	1.0	2.3	0.1	0.3	-1.0	-1.5	-1.4	-0.6	-1.2
Guilty feelings	0.2	0.3	1.3	-0.2	0.3	-0.4	-0.3	-0.4	0.4	-1.2
Wears glasses or contact lenses	0.6	0.7	2.0	0.3	0.1	1.0	1.3	0.5	1.4	-0.5
Ever taken oral contraceptive pill	3.2	3.6	10.1	0.5	0.6	-1.4	-2.0	-2.2	-1.8	-3.2
Hearing aid user	2.4	2.7	7.4	2.1	1.9	0.2	-2.7	-1.1	-1.5	0.0
Mother’s age at death	0.2	0.3	0.8	0.5	0.3	0.7	0.9	0.1	0.2	0.6
Financial situation satisfaction	1.2	1.5	3.1	0.5	-0.2	-0.8	-1.1	-1.5	-1.6	-1.8
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.7	-0.7	-0.4	-0.5	-0.4	-0.3	0.5	-0.8
Commuting to job workplace: Public transport	0.2	0.2	0.6	0.2	0.7	0.8	-0.1	0.4	-0.2	-0.0
Eye problems/disorders: Glaucoma	0.5	0.6	1.2	0.7	0.8	0.7	-1.0	-0.6	-1.1	0.1
Medication: Blood pressure	1.7	3.2	6.4	-0.1	0.3	1.1	2.3	2.5	2.1	2.3
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.6	-0.2	0.5	-0.2	-0.4	0.7	0.6	0.8
Supplements: Fish oil (including cod liver oil)	0.4	0.6	1.7	0.9	0.4	0.4	-0.1	-0.8	-0.7	-1.3
High cholesterol (Self-reported)	0.2	0.3	1.2	-0.2	-0.3	0.6	0.1	1.1	0.8	-0.3
Medication: Bendroflumethiazide	2.7	4.1	8.4	-0.4	1.2	1.4	1.9	2.4	2.7	2.9
Medication: Paracetamol	1.1	1.7	3.5	0.4	0.5	-1.4	-1.8	-1.6	-0.6	-1.9
Medication: Lisinopril	0.7	0.9	1.7	1.3	1.3	1.2	0.7	0.8	0.7	0.2
Medication: Atorvastatin	0.4	0.4	1.1	-1.0	-0.5	-0.8	-0.8	-0.1	0.0	-0.6
Illnesses of father: High blood pressure	0.7	0.8	3.1	-0.3	-0.5	0.1	0.2	1.4	0.8	1.8
Alcohol drinker status: Never	0.8	1.0	3.8	1.2	1.9	1.1	-0.5	0.1	0.1	-0.0
Ever smoked	0.3	0.6	1.3	0.7	0.9	1.1	0.4	0.7	0.6	0.5
Basal metabolic rate	0.6	3.0	8.0	-1.2	1.2	-1.4	-1.2	-2.8	-1.7	-2.1
Leg fat percentage (left)	1.5	5.6	13.7	-1.9	-2.0	0.0	3.1	2.4	3.7	1.5
Arm fat-free mass (left)	0.9	4.5	11.1	-1.1	0.9	-2.1	-1.7	-3.3	-2.4	-2.3
Number of operations (self-reported)	1.1	1.6	3.4	1.3	1.8	0.6	-1.8	-1.4	-0.6	0.2
Average weekly beer plus cider intake	0.7	1.0	3.1	0.9	0.8	1.8	0.9	0.3	1.0	0.9
Irritability	0.7	1.2	2.2	1.3	0.9	0.6	-1.5	-1.4	-1.0	-0.7
Risk taking	0.2	0.3	1.4	0.4	0.5	0.3	-0.2	0.1	1.2	-0.5
Ever had prostate specific antigen (PSA) test	2.5	2.9	6.5	2.3	1.4	0.8	-1.2	-1.8	-2.5	-1.2
Fractured/broken bones in last 5 years	0.2	0.2	0.6	-0.6	-0.4	-0.1	0.5	-0.3	0.6	-0.8
Age started oral contraceptive pill	0.8	1.1	2.1	-0.5	-0.7	-1.5	-1.2	-0.8	-1.4	-0.6
Diastolic blood pressure, automated reading	0.4	1.1	3.3	-1.8	-0.8	-1.3	0.8	1.1	0.6	0.5
Ever depressed for a whole week	2.6	3.2	6.2	-0.1	0.3	-1.8	-2.5	-1.8	-2.5	-1.9
Unable to work because of sickness or disability	0.3	0.3	1.1	0.6	0.1	0.3	-0.6	0.3	0.6	1.1
Commuting to job workplace: Cycle	2.1	2.6	8.4	1.5	0.9	-0.2	-2.9	-1.6	-1.9	-0.4
Myopia	0.4	0.5	2.1	-0.5	-0.1	0.7	1.5	0.5	0.7	0.2
Vascular/heart problems diagnosed by doctor	2.9	7.9	17.9	0.7	-1.2	-1.6	-3.1	-4.2	-3.4	-3.4
Cholesterol lowering medication	1.1	1.6	4.9	-0.5	-0.6	0.3	0.8	2.1	0.9	2.2
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	2.8	1.2	1.7	0.8	-0.9	-1.4	-1.6	-1.7
Pain experienced in last month	0.7	1.1	2.8	1.7	1.5	1.1	-0.4	0.4	-0.8	0.8
Supplements: Calcium	0.6	0.6	2.2	-1.5	-0.9	-0.7	0.3	0.6	0.7	-0.4
Basal cell carcinoma (self-reported)	0.4	0.5	0.9	-0.1	0.7	0.9	0.7	0.9	0.6	0.8
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.6	-0.0	0.8	0.3	-0.4	0.7	0.3	-0.2
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	4.2	1.0	1.6	2.0	0.2	0.6	0.7	1.2
Heart disease (siblings)	0.4	0.4	1.3	1.0	0.4	0.6	0.4	0.4	-0.1	1.2
Alcohol drinker status: Previous	1.2	1.4	5.3	0.9	0.9	-0.6	-2.3	-1.1	-0.8	-0.7
Pack years of smoking	0.5	0.7	1.7	-0.2	-0.7	-1.3	-0.7	-0.9	-0.6	-1.2
Impedance of whole body	1.2	6.2	17.4	0.5	-0.6	-1.0	-1.4	-3.5	-3.3	-4.2
Leg fat mass (left)	1.1	4.5	12.8	-2.0	-1.2	0.1	2.9	1.8	3.6	1.1
Arm predicted mass (left)	1.1	5.4	13.8	-1.0	1.1	-2.0	-2.0	-3.7	-2.6	-2.6