Hub : Genes

SLC11A1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.0663 0.0329 1.0e-03 0.069 0.019 0.072 0.056 0.068 1.5e-10 6.6e-04 7.0e-11 8.8e-09 1.9e-10
2 NTR Blood 0.0710 0.0267 6.0e-04 0.031 0.008 0.019 0.031 0.028 2.6e-10 1.2e-03 6.0e-07 1.8e-10 1.8e-09
3 YFS Blood 0.5211 0.0392 0.0e+00 0.167 0.226 0.258 0.252 0.263 3.3e-52 2.6e-72 4.0e-84 1.2e-81 5.1e-86
4 TCGA Breast Invasive Carcinoma 0.0185 0.0096 5.3e-04 0.023 0.007 0.014 NA 0.022 1.4e-05 8.9e-03 6.6e-04 NA 2.2e-05
5 TCGA Kidney Renal Clear Cell Carcinoma 0.0286 0.0161 2.8e-03 0.013 0.023 0.020 NA 0.018 1.1e-02 1.1e-03 2.1e-03 NA 3.2e-03
6 TCGA Lung Adenocarcinoma 0.0297 0.0160 1.6e-03 0.029 0.031 0.028 NA 0.028 2.4e-04 1.4e-04 2.6e-04 NA 2.5e-04
7 TCGA Lung Squamous Cell Carcinoma 0.0601 0.0263 1.6e-05 0.014 0.040 0.032 NA 0.033 7.9e-03 2.2e-05 1.3e-04 NA 1.2e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.1 0.1 0.5 0.7 0.1 0.4 -0.3 0.4 -0.2 0.2
Bipolar Disorder or Schizophrenia 0.1 0.2 0.5 -0.4 -0.7 -0.4 -0.2 0.3 0.4 0.0
Depressed Affect (Nagel 2018) 0.4 0.8 2.8 -0.4 -0.7 -1.7 -1.1 -0.6 0.0 -0.5
Depression (Nagel 2018) 0.2 0.2 0.5 0.1 0.1 -0.5 -0.7 -0.2 0.7 -0.7
Intelligence (Savage-Jansen 2018) 0.4 1.3 2.8 1.2 1.7 1.0 -0.1 -1.3 -0.9 -1.1
Neuroticism (Nagel 2018) 0.4 1.0 2.1 0.6 0.3 -1.0 -1.3 -1.2 -0.5 -1.5
Schizophrenia (2018) 0.2 0.5 1.2 -1.1 -1.1 -0.9 -0.0 0.0 0.7 -0.2
Schizophrenia vs Biploar Disorder 1.5 2.0 5.0 -2.0 -2.2 -1.9 0.4 0.3 0.8 -0.6
Worry (Nagel 2018) 0.8 1.6 2.8 1.3 1.1 -0.6 -1.7 -1.5 -0.9 -1.7
Alzheimer’s Disease (in mother) 1.2 1.5 5.1 0.5 0.5 0.1 -0.8 -1.8 -0.8 -2.3
Alzheimer’s Disease (in father) 4.3 4.6 12.0 -3.2 -3.5 -2.9 0.8 0.6 0.6 0.8
Alzheimer’s Disease (including proxy) 1.0 1.4 3.1 -1.8 -1.7 -0.9 1.4 -0.0 0.8 -0.6
Crohns Disease (2017) 2.0 4.3 7.4 -0.4 -1.3 1.5 2.7 2.7 2.4 2.5
Irritable Bowel Disease (IBD) 1.4 3.2 5.9 0.9 -0.5 2.2 2.0 2.4 1.8 1.8
Ulcerative Colitis (UC) 0.5 1.0 2.5 1.6 0.3 1.6 0.4 1.1 0.5 0.6
Major Depression (MDD) 0.8 1.0 2.5 -1.6 -1.3 0.0 0.0 0.8 1.4 0.7
Reaction Time 0.2 0.4 1.1 0.3 0.7 0.4 0.1 0.8 0.2 1.0
Verbal and Numeric Reasoning (VNR) 0.7 1.6 4.8 0.5 0.8 -0.1 -0.5 -2.2 -1.1 -2.0
Breast Cancer 0.3 0.6 2.0 0.9 0.3 1.4 0.8 0.8 0.5 0.1
Ovarian Cancer 1.6 2.1 5.1 -0.9 -0.8 -0.1 1.4 2.0 1.5 2.3
Prostate Cancer 0.1 0.1 0.4 0.1 0.7 -0.1 0.2 0.4 -0.0 0.6
Age at First Birth 0.7 1.1 3.6 -0.1 0.4 -0.1 0.2 1.5 1.2 1.9
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 -0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 4.8 6.6 15.3 -0.7 -0.3 1.6 2.6 3.3 3.9 3.1
Coronary Artery Disease (CAD) 0.5 0.6 1.9 -1.4 -0.7 -0.4 0.9 0.7 0.5 0.6
Crohns Disease (2012) 1.4 2.2 5.9 0.8 -0.6 1.2 2.4 1.7 1.3 1.6
Mean Putamen Volume 2.5 2.9 7.0 0.9 1.8 2.6 2.0 1.4 1.0 1.5
Fasting Glucose 0.5 0.6 2.0 1.4 0.2 0.5 -0.3 0.3 -0.8 1.2
HbA1C 0.9 1.0 2.9 -0.1 0.3 0.3 1.0 1.4 0.8 1.7
HDL Cholesterol 0.3 0.4 1.9 0.2 -0.2 -0.6 -1.4 -0.8 -0.2 -0.0
LDL Cholesterol 0.2 0.4 1.0 0.5 0.2 0.6 -0.7 -0.5 -1.0 -0.1
Lupus 0.7 1.0 2.6 1.6 1.3 0.6 -0.7 0.2 -0.6 1.3
Neuroticism (2016) 0.6 0.8 2.9 -0.7 -0.2 -0.8 -0.6 -1.1 0.0 -1.7
Primary Biliary Cirrhosis 0.9 1.3 2.9 1.7 1.1 1.3 0.1 -1.1 -1.0 -1.1
Rheumatoid Arthritis 0.4 0.6 1.9 0.2 0.6 -0.2 -0.5 -1.1 -1.4 -0.1
Schizophrenia (2014) 0.3 0.6 1.3 -1.1 -1.1 -1.0 -0.5 -0.3 0.5 -0.7
Triglycerides 0.4 0.7 1.4 0.7 1.2 0.9 0.6 -0.0 -0.6 -1.2
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.5 -0.6 -0.6 0.0 0.7 0.4 0.7 -0.4
Ulcerative Colitis 1.0 1.4 2.6 0.9 -0.3 1.5 1.3 1.6 1.1 1.1
Blood Eosinophil Count 0.5 3.7 6.6 2.6 2.2 1.1 -1.1 -2.4 -2.1 -1.4
Blood Platelet Count 8.5 99.0 237.2 -0.4 -1.1 6.8 8.8 15.4 13.6 12.1
Blood Red Count 4.6 44.9 104.9 1.4 2.0 -2.6 -4.7 -9.7 -8.9 -10.2
Blood White Count 0.4 2.9 11.6 1.4 3.4 0.5 -0.8 -1.5 -1.8 0.6
Heel T-Score 0.1 0.9 1.8 1.1 0.4 1.3 -1.0 0.5 -0.8 1.1
BMI 2.6 15.0 36.6 -2.3 -2.2 0.4 4.0 4.9 6.0 4.3
Height 7.2 138.3 299.3 -1.1 3.1 -7.8 -9.7 -17.3 -15.4 -16.3
Waist Hip Ratio (WHR) 0.2 0.7 1.8 1.0 -0.0 1.3 1.2 0.6 -0.6 0.5
Systolic Blood Pressure 0.9 4.3 10.7 -0.7 -0.6 1.2 2.7 3.3 2.1 2.4
Smoking Status 0.1 0.2 0.3 0.5 0.2 0.4 0.4 0.5 0.6 0.5
Allergy or Eczema 3.8 10.0 18.7 0.6 0.4 3.1 3.1 4.0 4.3 3.9
Cardiovascular Disease 1.2 4.1 9.1 -0.1 1.3 1.7 1.8 3.0 2.6 2.2
Hypothyroidism (self reported) 3.0 6.9 12.4 0.7 1.4 2.3 2.3 3.3 3.5 3.5
Respiratory disease 2.5 5.5 11.2 -0.0 -0.5 1.7 3.0 3.3 2.5 3.1
Type 2 Diabetes (T2D) (2018) 0.6 1.1 2.1 0.7 0.7 1.4 0.9 1.2 0.7 1.4
Lung FEV1/FVC ratio 0.2 0.9 2.2 0.4 0.8 1.0 0.6 0.9 1.5 1.0
Lung FVC 0.3 1.6 4.6 1.3 0.5 -0.3 -1.9 0.9 -0.7 2.1
Neuroticism 0.9 2.3 3.7 1.2 1.3 -0.4 -1.9 -1.9 -1.2 -1.9
Chronotype (morning person) 0.6 1.3 3.3 0.3 0.2 -0.3 -0.6 -1.5 -1.7 -1.8
Hair Pigment 0.0 0.2 0.5 -0.4 -0.4 -0.7 -0.1 0.4 0.7 0.4
Tanning 0.1 0.8 3.0 0.4 -0.1 -0.3 -1.3 0.7 -0.0 1.7
Hand grip strength (left) 3.0 8.0 16.7 0.4 1.1 -1.8 -3.4 -4.1 -3.5 -3.3
Number of treatments/medications taken 1.4 2.5 6.3 -0.5 0.1 0.9 1.7 2.2 2.5 1.6
Average weekly spirits intake 0.8 0.9 2.8 0.7 0.8 0.9 0.3 1.1 0.6 1.7
Sensitivity / hurt feelings 0.2 0.4 0.9 0.1 -0.7 -0.7 0.4 0.2 0.7 -1.0
Frequency of depressed mood in last 2 weeks 0.9 1.3 2.6 1.5 1.3 0.4 -1.2 -0.9 -0.2 -1.6
Hearing difficulty/problems: Yes 0.5 0.8 3.5 -0.2 0.2 -1.1 -1.9 -0.7 -0.5 -0.3
Relative age of first facial hair 1.0 2.1 5.3 -1.0 -1.2 0.7 1.5 1.5 2.3 1.3
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.8 0.1 0.4 -0.3 0.3 0.4 0.9 0.1
Ever used hormone-replacement therapy (HRT) 1.6 2.0 3.8 1.1 -0.2 -0.9 -1.9 -1.6 -1.7 -1.7
Ever had hysterectomy (womb removed) 1.4 1.6 3.3 -1.1 -1.5 -1.8 -0.8 -1.1 -1.3 -1.1
Systolic blood pressure, automated reading 1.9 5.6 12.4 -1.2 -1.9 0.3 2.6 3.5 2.7 2.7
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 2.4 1.0 0.2 1.4 0.2 0.7 0.5 1.6
Angina 0.4 0.6 1.5 -0.4 -0.2 0.2 1.2 1.1 0.4 0.9
Medication for hormone replacement therapy 0.5 0.5 1.3 -0.3 -0.8 -1.1 -1.0 0.5 -0.4 0.5
Vitamin and mineral supplements 1.1 1.4 4.0 2.0 1.8 1.1 -0.8 -0.4 -0.9 0.3
Supplements: Zinc 0.3 0.4 1.1 -1.0 -0.3 0.3 0.4 0.1 0.1 -1.0
Medication: Co-codamol 0.8 1.0 2.5 0.3 -0.2 0.5 0.8 1.6 1.1 1.4
Medication: Metformin 1.2 1.7 4.0 1.4 0.7 2.0 1.1 1.0 1.1 1.4
Diabetes (father) 0.3 0.4 1.3 0.2 -0.9 0.2 0.4 1.1 0.5 -0.1
Diabetes (mother) 0.6 0.8 2.0 -1.4 -0.5 -0.6 0.5 1.1 1.3 -0.0
Severe depression (siblings) 2.2 2.5 6.1 -2.5 -2.3 -1.8 1.1 0.5 0.8 -0.7
Pack years adult smoking proportion 0.3 0.5 1.5 -0.1 -0.7 -1.2 -0.7 -0.5 -0.3 -0.9
Impedance of leg (right) 2.4 11.7 24.6 0.5 -0.7 -2.0 -2.5 -4.9 -4.7 -5.0
Leg fat-free mass (left) 0.1 0.7 2.2 -1.5 0.7 -0.7 0.2 -1.1 0.0 -0.8
Trunk fat percentage 1.6 6.2 14.5 -2.5 -2.0 0.2 3.7 2.1 3.8 0.9
Hand grip strength (right) 2.9 7.8 15.8 0.8 0.9 -1.5 -3.1 -4.0 -3.9 -3.2
Townsend deprivation index at recruitment 1.2 1.7 4.3 0.5 0.7 1.3 0.4 1.9 1.1 2.1
Current tobacco smoking 0.1 0.1 0.4 0.6 -0.2 -0.3 -0.6 -0.2 0.2 -0.3
Average weekly fortified wine intake 1.0 1.1 3.5 1.0 1.8 1.9 -0.3 -0.1 0.2 0.2
Maternal smoking around birth 0.2 0.3 1.1 -0.6 -0.0 -0.8 0.1 -0.0 1.0 -0.5
Fed-up feelings 0.4 0.7 1.6 0.2 -0.7 -1.0 -1.3 -0.6 -0.9 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.6 2.0 -0.6 -0.6 -1.0 -0.6 0.0 1.4 -0.7
Relative age voice broke 0.7 1.0 2.9 -0.9 -1.7 -0.2 0.4 1.1 1.4 0.3
Taking other prescription medications 2.1 3.3 6.9 0.3 0.8 1.5 1.3 2.5 2.4 2.6
Age when periods started (menarche) 0.2 0.5 1.0 -1.0 -1.0 -0.7 -0.0 0.6 0.1 0.8
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.2 -0.4 -0.1 -0.2 0.1 0.2 -0.2 0.3
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.2 7.1 1.7 2.1 2.7 -0.1 -0.2 0.0 -0.8
Tinnitus: Yes, but not now, but have in the past 5.0 5.3 10.1 -3.2 -2.6 -1.3 2.7 2.3 1.7 1.9
Qualifications: CSEs or equivalent 0.0 0.1 0.2 -0.2 -0.4 0.4 -0.0 -0.1 -0.3 0.0
Serious illness, injury or assault to yourself 0.6 0.7 2.1 -1.5 -0.7 -0.6 0.1 0.8 0.6 1.1
High blood pressure 2.8 7.8 17.2 -0.6 1.1 1.6 3.0 4.2 3.5 3.4
Hayfever, allergic rhinitis or eczema 2.7 6.0 10.0 0.5 0.4 2.5 2.5 3.2 3.1 3.1
Multivitamins +/- minerals 1.6 2.0 5.2 -2.3 -2.3 -1.6 0.2 -0.3 0.3 -0.9
Stomach or abdominal pain in last month 0.7 0.9 2.3 -1.4 -1.5 -0.6 0.0 0.5 1.0 0.6
Supplements: Glucosamine 0.8 1.1 1.8 -1.2 -1.3 -1.3 -0.4 -1.1 -0.1 -1.2
Diverticular disease/diverticulitis (self-reported) 1.2 1.4 4.3 -0.3 -0.4 0.6 2.1 1.3 1.4 1.1
Medication: Atenolol 0.9 1.1 3.5 0.2 1.3 -0.5 -1.9 -0.8 -1.0 -0.6
Medication: Levothyroxine sodium 1.2 2.1 5.6 0.7 1.3 1.1 0.7 2.0 1.0 2.4
Sitting height 4.5 31.9 65.8 -0.9 1.9 -3.9 -5.7 -8.1 -7.0 -7.6
Chronic bronchitis/emphysema (father) 0.0 0.0 0.1 0.2 0.4 0.3 -0.0 -0.2 -0.1 -0.1
High blood pressure (mother) 0.8 1.1 2.4 -1.2 -0.3 -0.0 0.6 1.5 1.6 1.1
Body mass index (BMI) 3.5 14.7 33.1 -2.2 -1.6 1.1 4.4 4.9 5.8 4.2
Impedance of leg (left) 2.8 13.7 29.9 1.1 0.1 -1.8 -3.0 -5.3 -5.0 -5.5
Leg predicted mass (left) 0.1 0.7 2.0 -1.4 0.8 -0.7 0.1 -1.1 -0.0 -0.8
Trunk fat mass 0.7 3.1 6.7 -2.4 -1.4 -0.5 2.6 0.7 2.6 -0.1
Waist circumference 0.7 2.7 6.1 -1.7 -1.0 0.3 2.2 1.5 2.5 1.3
Number of incorrect matches in round 0.1 0.1 0.2 0.1 0.4 0.5 -0.4 0.1 -0.1 -0.3
Past tobacco smoking 0.3 0.5 0.9 -0.2 -0.5 -0.8 -0.7 -0.9 -1.0 -0.5
Alcohol usually taken with meals 1.9 3.1 7.2 0.9 1.2 -0.1 -1.5 -2.7 -1.9 -2.4
Nervous feelings 0.4 0.7 1.9 -0.0 -0.6 -1.4 -1.0 -0.9 -0.2 -1.1
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.1 2.3 1.0 1.1 -0.3 -1.3 -0.9 -0.6 -1.5
Hearing difficulty/problems with background noise 1.7 2.7 6.7 -0.1 0.0 -1.6 -2.0 -2.1 -1.0 -2.6
Hair/balding pattern: Pattern 2 0.4 0.5 1.2 -0.7 -1.1 0.2 1.0 0.6 0.6 0.2
Had menopause 1.8 2.2 7.7 -1.8 -2.8 -2.1 0.5 0.0 0.0 -0.2
Had other major operations 0.1 0.1 0.3 -0.1 0.1 -0.5 -0.4 -0.5 -0.4 0.0
Forced vital capacity (FVC) 3.3 12.7 26.8 1.1 2.1 -2.0 -4.5 -4.5 -5.2 -3.5
Heel bone mineral density (BMD) T-score, automated (right) 0.6 1.3 4.1 1.1 1.9 2.0 -0.4 -0.2 -0.1 -0.7
Ever unenthusiastic/disinterested for a whole week 1.6 1.9 4.1 -0.5 0.1 -1.3 -2.0 -1.8 -1.2 -1.7
Qualifications: None of the above 2.4 5.2 11.2 1.4 0.7 1.9 1.0 2.8 3.4 3.2
Financial difficulties in last 2 years 0.5 0.7 1.9 -0.1 0.2 -0.6 -1.2 -1.0 -0.6 -1.4
Mouth/teeth dental problems 2.3 3.5 10.2 1.2 0.5 -0.5 0.4 -2.5 -2.4 -3.2
Heart attack 0.1 0.2 0.5 -0.2 0.7 0.1 -0.4 0.7 0.2 -0.1
Allergy 2.6 6.0 11.2 -0.9 -0.5 -2.5 -2.0 -3.3 -2.9 -3.3
Pain all over the body in last month 0.2 0.2 0.4 -0.1 -0.1 0.3 0.6 0.5 0.4 0.5
Diabetes (self-reported) 1.1 1.6 5.4 0.8 0.3 1.4 0.7 1.7 0.6 2.3
Hayfever/allergic rhinitis (self-reported) 3.1 4.1 8.4 0.7 0.6 2.3 1.7 2.9 2.2 2.5
Medication: Ramipril 5.1 6.5 15.1 -1.2 -0.8 1.6 3.9 3.3 3.0 2.4
Medication: Simvastatin 2.1 3.0 7.4 -0.5 -0.1 1.0 2.2 2.7 1.3 2.4
Fluid intelligence score 0.8 1.6 4.5 0.6 0.9 0.1 -1.0 -2.1 -1.3 -1.6
Illnesses of siblings 0.3 0.5 1.0 0.6 0.4 0.7 -0.4 0.9 0.6 1.0
Neuroticism score 1.6 3.2 7.5 0.3 0.3 -1.4 -2.6 -2.3 -1.1 -2.7
Weight 0.2 1.2 4.5 -2.1 -0.4 -1.0 1.1 -0.5 0.9 -0.6
Impedance of arm (right) 0.3 1.3 4.6 0.5 -0.1 0.4 -0.1 -1.5 -1.2 -2.1
Arm fat percentage (right) 3.6 14.3 32.6 -2.5 -1.9 1.3 4.9 4.5 5.7 3.5
Trunk fat-free mass 1.7 9.6 22.8 -0.4 2.3 -1.9 -2.9 -4.8 -3.9 -3.3
Hip circumference 0.3 1.2 4.6 -2.1 -0.2 -0.4 1.1 -0.1 1.5 -0.1
Time employed in main current job 1.9 2.2 5.4 2.1 2.3 1.5 -1.0 0.0 -0.6 1.3
Alcohol intake versus 10 years previously 2.0 3.0 5.4 -1.4 -1.4 0.0 2.0 2.3 1.4 2.3
Father’s age at death 0.2 0.3 0.9 0.1 0.1 0.2 -1.0 0.1 -0.6 0.9
Worrier / anxious feelings 0.1 0.2 0.6 -0.4 -0.3 -0.3 0.5 -0.2 0.1 -0.8
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 1.0 0.1 0.4 -0.0 0.2 -0.2 0.4 -1.0
Falls in the last year 0.8 1.1 2.0 0.1 0.3 1.2 1.2 1.1 1.4 1.2
Hair/balding pattern: Pattern 3 2.4 3.6 8.0 2.5 2.8 1.2 -1.6 -1.6 -1.8 -1.2
Number of live births 0.3 0.4 0.8 0.9 0.6 0.9 -0.5 -0.4 -0.4 0.2
Forced expiratory volume in 1-second (FEV1) 2.4 8.1 16.1 1.4 2.3 -1.0 -3.6 -3.4 -4.0 -2.6
Pulse rate 0.1 0.1 0.3 -0.3 -0.2 -0.1 0.3 -0.0 -0.6 -0.2
Happiness 2.9 3.5 7.4 1.0 1.4 -0.4 -2.7 -2.1 -1.6 -2.6
Noisy workplace 1.1 1.4 4.8 -0.5 -0.1 0.5 0.3 1.6 1.2 2.2
Qualifications: A levels/AS levels or equivalent 3.9 8.5 16.6 1.1 2.2 -0.1 -2.8 -4.1 -3.9 -3.7
Serious illness, injury or assault of a close relative in last 2 years 2.2 2.5 5.3 -1.4 -1.3 -0.1 1.6 1.8 2.3 1.6
Mouth/teeth dental problems: Dentures 2.0 3.3 9.4 0.1 1.0 1.5 -0.1 2.4 2.2 3.1
Asthma 0.8 1.6 4.2 -0.1 -0.6 0.7 1.4 2.0 1.3 1.6
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.6 1.3 -0.1 0.7 0.4 1.1 0.5 0.8 -1.0
Medication: Cholesterol lowering 0.4 0.6 1.2 -0.2 0.1 0.9 1.0 1.1 1.1 -0.2
Depression (self-reported) 1.6 1.9 4.7 -1.0 -1.2 -1.4 -1.2 -1.5 -0.7 -2.2
Medication: Lansoprazole 0.4 0.5 1.8 -0.8 -0.2 0.1 1.4 0.1 0.7 -0.3
Prospective memory result 0.5 0.6 2.0 -1.0 -1.4 -1.0 0.5 0.4 0.1 0.5
Lung cancer (father) 0.3 0.3 0.7 -0.2 -0.6 -0.6 0.3 0.8 0.6 0.7
Illnesses of mother 1.7 2.1 5.3 1.1 -0.2 -0.3 -1.3 -2.3 -2.2 -1.3
Forced expiratory volume in 1-second (FEV1), Best measure 2.0 6.3 12.7 1.8 2.4 -0.4 -3.2 -3.0 -3.6 -1.9
Pulse wave Arterial Stiffness index 0.6 0.7 1.1 -1.1 -0.9 -0.9 0.8 -0.5 -0.8 -1.0
Impedance of arm (left) 0.3 1.3 4.5 0.5 -0.3 0.3 -0.3 -1.4 -1.5 -2.1
Arm fat mass (right) 2.0 8.3 19.4 -2.5 -1.4 0.5 3.8 3.2 4.4 2.5
Trunk predicted mass 1.7 9.7 23.0 -0.4 2.3 -1.9 -2.9 -4.8 -4.0 -3.4
Standing height 5.8 57.1 127.7 0.1 2.7 -4.5 -6.7 -11.3 -10.0 -10.0
Length of working week for main job 0.5 0.6 1.1 -1.0 -0.6 -1.0 0.3 0.6 1.0 -0.0
Exposure to tobacco smoke at home 0.5 0.5 1.8 -1.4 -0.8 -0.6 -0.1 -0.1 0.9 0.0
Breastfed as a baby 1.0 1.2 3.3 1.4 1.8 1.4 0.4 -0.8 -0.6 -0.3
Tense / ‘highly strung’ 1.4 2.3 5.3 -0.6 0.2 -1.7 -2.3 -1.8 -0.8 -2.0
Seen doctor (GP) for nerves, anxiety, tension or depression 2.6 4.0 10.4 -2.4 -2.1 -3.2 -1.1 -1.0 -0.2 -2.2
Hair/balding pattern: Pattern 4 0.1 0.3 1.2 1.1 0.6 0.1 -0.1 -0.8 -0.1 0.4
Birth weight of first child 0.3 0.6 1.4 -0.6 -0.4 -1.2 -0.8 -1.0 -0.8 0.0
Peak expiratory flow (PEF) 1.4 3.1 7.6 0.7 1.5 -0.9 -2.7 -1.9 -2.6 -0.9
Pulse wave reflection index 2.6 3.2 6.3 0.3 0.7 -1.2 -1.5 -2.5 -2.4 -2.5
Ever highly irritable/argumentative for 2 days 0.4 0.4 1.3 0.0 0.0 0.5 0.6 1.0 0.4 1.2
Loud music exposure frequency 0.6 0.7 3.9 -2.0 -0.4 -0.6 0.1 0.1 0.1 -0.4
Qualifications: O levels/GCSEs or equivalent 2.5 3.9 9.2 0.9 1.6 -0.1 -1.8 -2.4 -3.0 -2.5
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 1.3 -0.7 -0.4 -0.2 -1.1 -0.2 0.4 -0.0
Blood clot in the leg (DVT) 1.0 1.3 3.8 1.1 1.6 1.9 -0.0 0.4 0.6 1.1
Medication: Paracetamol 1.6 2.6 5.4 0.7 1.0 -1.3 -2.1 -2.2 -1.0 -2.3
Headache pain in last month 0.3 0.6 1.9 -0.3 0.2 -0.3 -0.5 -1.0 0.8 -1.4
Medication for cholesterol, blood pressure or diabetes 0.8 1.4 4.0 0.3 -0.1 -0.9 -1.3 -1.7 -2.0 -0.4
Glaucoma (self-reported) 0.7 0.8 1.9 0.8 1.2 0.5 -1.4 -0.7 -1.0 -0.2
Gout (self-reported) 1.2 1.7 3.9 -1.1 -0.9 -0.6 0.9 2.0 1.3 1.8
Hypothyroidism/myxoedema (self-reported) 2.0 3.8 10.6 0.9 1.4 1.7 0.8 2.5 1.9 3.2
Medication: Amlodipine 2.1 3.0 7.5 -1.0 -0.0 0.5 1.1 2.7 2.1 2.6
Medication: Ventolin 100micrograms inhaler 0.5 0.6 1.9 -1.0 -0.8 -0.3 0.6 0.2 1.4 -0.2
Birth weight 0.8 1.7 5.1 -0.9 -1.6 -2.3 -0.2 -1.1 -1.3 -0.6
Chronic bronchitis/emphysema (mother) 1.1 1.2 2.9 -0.7 -0.6 0.2 1.0 1.7 1.6 1.2
High blood pressure (siblings) 0.3 0.4 1.0 -1.0 -0.3 -0.7 0.2 -0.7 -0.4 -0.7
Forced vital capacity (FVC), Best measure 2.8 10.4 22.8 1.6 2.0 -1.6 -4.1 -4.0 -4.8 -2.8
Body fat percentage 2.0 8.0 18.7 -2.6 -2.3 0.3 4.0 2.7 4.3 1.4
Leg fat percentage (right) 1.8 6.6 14.3 -2.2 -2.5 0.0 3.4 2.6 3.8 1.8
Arm fat-free mass (right) 1.1 5.9 14.1 -0.7 1.2 -2.0 -2.1 -3.8 -2.9 -2.8
Exposure to tobacco smoke outside home 0.7 1.0 2.7 -0.7 -0.4 0.2 1.6 0.7 1.5 0.7
Comparative body size at age 10 1.5 4.2 13.0 -0.9 -0.6 -0.3 0.8 3.0 2.5 3.6
Number of full brothers 0.2 0.3 0.8 -0.9 -0.6 -0.3 0.4 -0.2 0.2 -0.7
Worry too long after embarrassment 1.1 1.9 9.0 0.1 0.0 -0.2 -0.2 -1.9 -0.8 -3.0
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 2.7 -0.7 -0.7 -1.6 -1.3 -0.2 -0.2 -0.4
Wheeze or whistling in the chest in last year 0.8 1.4 4.8 0.3 0.3 1.2 -0.0 1.3 2.2 1.1
Number of children fathered 0.3 0.4 1.0 -0.1 0.2 0.7 1.0 0.5 1.0 0.2
Reason for reducing amount of alcohol drunk: Health precaution 1.5 1.8 3.5 1.9 1.4 0.7 -1.1 -1.2 -1.5 -1.4
Age at first live birth 0.5 0.8 2.3 -0.7 -1.5 -0.7 1.3 -0.3 -0.8 -0.3
Pulse wave peak to peak time 0.5 0.6 2.3 1.0 0.9 0.3 -1.5 -0.3 0.1 0.2
Health satisfaction 0.3 0.4 1.6 -0.2 -0.1 -0.1 -0.3 -0.7 -0.7 -1.2
Shortness of breath walking on level ground 0.4 0.5 1.0 0.1 0.4 0.9 1.0 0.6 0.6 0.9
Qualifications: College or University degree 0.4 1.2 3.1 0.4 1.2 0.5 0.5 -1.5 -1.0 -1.8
Eye problems/disorders: None of the above 0.5 0.6 3.3 0.1 0.3 -0.4 0.1 -0.5 0.4 -1.8
Mouth/teeth dental problems: Loose teeth 2.3 2.7 4.7 -1.2 -0.6 -1.9 -2.1 -1.6 -1.4 -2.2
Emphysema/chronic bronchitis 0.9 1.0 3.0 1.5 0.6 1.7 1.0 0.1 0.6 0.3
Medication for pain relief, constipation, heartburn 0.1 0.2 0.6 0.2 -0.8 0.2 -0.1 -0.2 -0.6 0.5
Neck or shoulder pain in last month 1.9 2.7 6.4 -2.4 -2.3 -2.5 0.3 0.3 0.8 0.3
Medication: Blood pressure 2.1 3.7 9.1 -0.3 1.2 1.4 1.7 2.6 3.0 1.8
Angina (self-reported) 0.4 0.6 1.3 -0.7 -0.4 0.0 1.1 1.1 0.4 0.8
Migraine (self-reported) 0.2 0.2 0.4 0.6 0.3 0.1 0.5 0.5 0.4 -0.6
Medication: Ibuprofen 0.9 1.1 2.9 -0.3 0.3 0.5 1.7 1.3 1.5 -0.2
Medication: Allopurinol 0.6 0.8 2.4 -0.4 -0.7 -0.6 0.5 1.5 1.2 0.8
Medication: Omeprazole 0.8 1.0 2.1 0.6 0.7 0.2 -0.8 -1.2 -1.3 -1.5
Medication: Seretide 50 evohaler 0.1 0.1 0.3 0.1 -0.3 -0.0 -0.3 0.4 0.5 0.4
Mean time to correctly identify matches 0.3 0.5 1.4 0.6 0.5 0.8 0.3 0.8 0.3 1.2
Heart disease (mother) 1.4 1.7 3.8 -1.9 -0.2 -1.2 0.5 1.7 0.8 1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.4 1.6 3.4 -0.3 -1.4 -0.1 1.6 1.8 1.5 1.1
Whole body fat mass 1.0 4.4 10.6 -2.4 -1.4 -0.1 3.0 1.5 3.2 0.8
Leg fat mass (right) 1.2 4.8 12.7 -2.2 -1.4 0.1 3.1 1.9 3.6 1.2
Arm predicted mass (right) 1.0 5.0 12.1 -0.8 1.1 -2.0 -1.8 -3.5 -2.6 -2.7
Pulse rate, automated reading 0.4 1.2 3.6 0.0 -0.4 -0.9 -0.6 -1.5 -1.1 -1.9
Alcohol intake frequency. 0.6 1.5 2.7 -1.3 -0.8 -1.4 0.2 1.6 1.6 0.8
Comparative height size at age 10 6.2 34.0 77.1 -0.0 2.2 -3.7 -5.5 -8.8 -7.7 -7.3
Number of full sisters 0.8 1.0 2.0 0.8 0.7 1.0 0.0 1.3 1.0 1.4
Suffer from ‘nerves’ 0.6 0.9 2.4 -0.3 -0.6 -1.6 -1.4 -0.6 0.2 -1.1
Overall health rating 0.5 1.1 3.2 0.6 0.6 1.4 0.2 1.0 1.8 0.9
Chest pain or discomfort 0.6 0.8 2.6 -1.6 -0.8 -0.6 1.1 0.1 0.7 -0.6
Had major operations 0.4 0.4 0.8 0.4 0.9 0.8 0.2 -0.8 0.6 -0.3
Age at last live birth 0.2 0.2 0.5 0.3 -0.6 0.1 0.2 -0.5 -0.7 -0.7
Family relationship satisfaction 1.8 2.2 4.9 1.2 0.6 -0.3 -1.7 -1.8 -1.6 -2.2
Leg pain on walking 0.4 0.5 1.0 -1.0 -0.9 -0.4 0.7 0.6 0.1 0.7
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.4 3.6 -1.9 -1.6 -1.6 0.6 0.4 -0.5 0.1
Commuting to job workplace: Car/motor vehicle 0.5 0.6 2.1 -0.9 -1.0 -1.4 0.3 0.1 -0.0 -0.2
Illness, injury, bereavement, stress in last 2 years 0.3 0.3 0.7 0.8 0.4 0.2 0.1 -0.7 -0.7 -0.7
Medication: Aspirin 0.8 1.0 2.1 -1.0 -0.5 -0.2 0.9 1.4 1.2 1.1
Supplements: Vitamin C 0.2 0.2 0.7 -0.8 -0.1 -0.0 0.8 -0.1 -0.1 0.4
Knee pain experienced in last month 0.5 0.7 1.7 -1.1 0.1 0.0 1.0 0.9 1.3 0.6
Hypertension (Self-reported) 2.8 7.7 16.2 -0.3 1.1 1.9 2.8 4.0 3.5 3.5
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.8 0.9 1.5 -1.0 -1.0 0.1 1.2 1.2 1.2 0.1
Illnesses of father: Heart disease 0.3 0.4 0.7 -0.2 -0.2 -0.7 -0.0 -0.8 -0.9 -0.9
Illnesses of siblings: Diabetes 0.7 0.9 2.0 -0.2 0.1 0.9 1.2 1.4 1.3 -0.0
Smoking status: Previous 0.6 1.0 2.2 -0.1 0.2 0.8 1.0 1.5 1.3 1.1
Forced expiratory volume in 1-second (FEV1), predicted 4.0 8.2 16.3 0.7 1.8 -1.0 -3.2 -3.9 -4.0 -3.3
Whole body fat-free mass 0.8 4.7 11.8 -0.7 1.8 -1.5 -1.8 -3.4 -2.4 -2.5
Leg fat-free mass (right) 0.2 0.9 1.9 -0.9 1.3 -0.5 -0.3 -1.4 -0.3 -1.1
Arm fat percentage (left) 3.7 14.9 33.5 -2.3 -1.9 1.5 5.0 4.7 5.8 3.6
Average weekly red wine intake 3.3 4.8 11.1 3.3 3.3 1.8 -1.7 -1.8 -1.6 -0.4
Handedness (chirality/laterality): Left-handed 1.7 2.0 6.0 -2.4 -1.8 -1.9 0.5 -0.2 -1.1 0.1
Mood swings 0.3 0.5 1.2 -0.4 -0.5 -0.7 -0.8 -1.1 -0.2 -1.0
Loneliness, isolation 0.5 0.8 2.1 0.1 -0.7 -1.4 -1.2 -0.7 0.5 -0.8
Long-standing illness, disability or infirmity 1.6 2.5 5.2 -1.1 -1.1 -0.1 1.2 2.3 1.9 2.1
Ever had bowel cancer screening 0.7 0.9 2.2 -1.1 -1.5 -0.7 0.8 0.9 0.8 0.2
Diabetes diagnosed by doctor 1.2 2.0 3.9 0.9 0.4 1.7 1.2 1.8 1.1 2.0
Ever had stillbirth, spontaneous miscarriage or termination 1.1 1.2 1.9 0.7 1.1 1.4 -0.9 -1.1 -1.1 -1.2
Friendships satisfaction 2.0 2.4 5.7 1.4 0.5 -0.5 -2.4 -1.7 -2.2 -1.1
Qualifications: nursing, teaching 0.4 0.7 1.6 0.7 0.4 -0.1 -0.6 -1.2 -1.2 -0.8
Commuting to job workplace: Walk 1.2 1.3 2.2 1.3 1.1 1.1 -1.1 -1.2 -1.5 -0.6
Eye problems/disorders: Cataract 1.3 1.5 4.8 0.9 1.0 1.5 0.8 1.0 0.2 2.2
Mouth/teeth dental problems: Mouth ulcers 0.5 0.8 1.7 -0.7 -1.3 -0.4 0.5 1.0 0.9 1.0
Medication for cholesterol 2.0 3.0 7.2 0.6 0.2 -0.5 -1.5 -2.7 -2.2 -2.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.5 1.8 4.3 -0.1 0.1 0.3 0.7 2.1 2.0 1.9
Back pain experienced in last month 0.8 1.2 2.7 -1.0 -1.6 -0.4 1.6 0.6 1.2 0.5
Mineral and other dietary supplements 1.2 1.6 4.0 1.1 0.9 1.4 0.8 1.4 0.8 2.0
Breast cancer (self-reported) 1.3 1.5 3.1 0.3 0.7 -0.5 -1.4 -1.8 -1.8 -1.2
Asthma (self-reported) 0.7 1.4 3.7 0.0 -0.5 0.7 1.3 1.9 1.2 1.5
Osteoporosis (self-reported) 0.5 0.6 2.6 0.6 -0.0 0.3 0.5 0.9 0.3 1.6
Osteoarthritis (self-reported) 0.8 1.0 3.2 -0.5 0.2 0.4 0.7 1.2 1.8 1.1
Medication: Aspirin 0.2 0.3 0.7 -0.9 -0.3 -0.5 0.1 0.6 0.5 0.4
Medication: Gliclazide 0.5 0.6 2.2 1.5 0.4 -0.0 -0.7 -0.3 -0.7 0.6
Illnesses of father: None of the above (group 1) 1.0 1.3 2.5 0.5 0.6 -0.3 -1.4 -1.6 -1.6 -1.2
Smoking status: Current 0.1 0.1 0.6 0.8 -0.1 -0.0 -0.3 0.1 0.4 -0.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 1.5 0.6 0.8 1.2 0.4 0.6 -0.7 1.2
Whole body water mass 0.8 4.4 11.2 -0.6 1.8 -1.4 -1.8 -3.4 -2.4 -2.3
Leg predicted mass (right) 0.2 0.9 1.8 -1.0 1.2 -0.6 -0.3 -1.4 -0.3 -1.1
Arm fat mass (left) 1.9 7.9 18.8 -2.3 -1.4 0.5 3.7 3.1 4.3 2.5
Number of self-reported non-cancer illnesses 2.0 3.5 7.3 0.3 0.7 1.6 1.4 2.7 2.2 2.7
Average weekly champagne plus white wine intake 1.1 1.5 2.8 1.7 1.1 0.7 -1.2 -1.3 -0.8 -1.6
Miserableness 0.6 1.0 2.3 0.1 0.3 -1.0 -1.5 -1.4 -0.6 -1.2
Guilty feelings 0.2 0.3 1.3 -0.2 0.3 -0.4 -0.3 -0.4 0.4 -1.2
Wears glasses or contact lenses 0.6 0.7 2.0 0.3 0.1 1.0 1.3 0.5 1.4 -0.5
Ever taken oral contraceptive pill 3.2 3.6 10.1 0.5 0.6 -1.4 -2.0 -2.2 -1.8 -3.2
Hearing aid user 2.4 2.7 7.4 2.1 1.9 0.2 -2.7 -1.1 -1.5 0.0
Mother’s age at death 0.2 0.3 0.8 0.5 0.3 0.7 0.9 0.1 0.2 0.6
Financial situation satisfaction 1.2 1.5 3.1 0.5 -0.2 -0.8 -1.1 -1.5 -1.6 -1.8
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.7 -0.7 -0.4 -0.5 -0.4 -0.3 0.5 -0.8
Commuting to job workplace: Public transport 0.2 0.2 0.6 0.2 0.7 0.8 -0.1 0.4 -0.2 -0.0
Eye problems/disorders: Glaucoma 0.5 0.6 1.2 0.7 0.8 0.7 -1.0 -0.6 -1.1 0.1
Medication: Blood pressure 1.7 3.2 6.4 -0.1 0.3 1.1 2.3 2.5 2.1 2.3
Pain type(s) experienced in last month: Hip pain 0.2 0.3 0.6 -0.2 0.5 -0.2 -0.4 0.7 0.6 0.8
Supplements: Fish oil (including cod liver oil) 0.4 0.6 1.7 0.9 0.4 0.4 -0.1 -0.8 -0.7 -1.3
High cholesterol (Self-reported) 0.2 0.3 1.2 -0.2 -0.3 0.6 0.1 1.1 0.8 -0.3
Medication: Bendroflumethiazide 2.7 4.1 8.4 -0.4 1.2 1.4 1.9 2.4 2.7 2.9
Medication: Paracetamol 1.1 1.7 3.5 0.4 0.5 -1.4 -1.8 -1.6 -0.6 -1.9
Medication: Lisinopril 0.7 0.9 1.7 1.3 1.3 1.2 0.7 0.8 0.7 0.2
Medication: Atorvastatin 0.4 0.4 1.1 -1.0 -0.5 -0.8 -0.8 -0.1 0.0 -0.6
Illnesses of father: High blood pressure 0.7 0.8 3.1 -0.3 -0.5 0.1 0.2 1.4 0.8 1.8
Alcohol drinker status: Never 0.8 1.0 3.8 1.2 1.9 1.1 -0.5 0.1 0.1 -0.0
Ever smoked 0.3 0.6 1.3 0.7 0.9 1.1 0.4 0.7 0.6 0.5
Basal metabolic rate 0.6 3.0 8.0 -1.2 1.2 -1.4 -1.2 -2.8 -1.7 -2.1
Leg fat percentage (left) 1.5 5.6 13.7 -1.9 -2.0 0.0 3.1 2.4 3.7 1.5
Arm fat-free mass (left) 0.9 4.5 11.1 -1.1 0.9 -2.1 -1.7 -3.3 -2.4 -2.3
Number of operations (self-reported) 1.1 1.6 3.4 1.3 1.8 0.6 -1.8 -1.4 -0.6 0.2
Average weekly beer plus cider intake 0.7 1.0 3.1 0.9 0.8 1.8 0.9 0.3 1.0 0.9
Irritability 0.7 1.2 2.2 1.3 0.9 0.6 -1.5 -1.4 -1.0 -0.7
Risk taking 0.2 0.3 1.4 0.4 0.5 0.3 -0.2 0.1 1.2 -0.5
Ever had prostate specific antigen (PSA) test 2.5 2.9 6.5 2.3 1.4 0.8 -1.2 -1.8 -2.5 -1.2
Fractured/broken bones in last 5 years 0.2 0.2 0.6 -0.6 -0.4 -0.1 0.5 -0.3 0.6 -0.8
Age started oral contraceptive pill 0.8 1.1 2.1 -0.5 -0.7 -1.5 -1.2 -0.8 -1.4 -0.6
Diastolic blood pressure, automated reading 0.4 1.1 3.3 -1.8 -0.8 -1.3 0.8 1.1 0.6 0.5
Ever depressed for a whole week 2.6 3.2 6.2 -0.1 0.3 -1.8 -2.5 -1.8 -2.5 -1.9
Unable to work because of sickness or disability 0.3 0.3 1.1 0.6 0.1 0.3 -0.6 0.3 0.6 1.1
Commuting to job workplace: Cycle 2.1 2.6 8.4 1.5 0.9 -0.2 -2.9 -1.6 -1.9 -0.4
Myopia 0.4 0.5 2.1 -0.5 -0.1 0.7 1.5 0.5 0.7 0.2
Vascular/heart problems diagnosed by doctor 2.9 7.9 17.9 0.7 -1.2 -1.6 -3.1 -4.2 -3.4 -3.4
Cholesterol lowering medication 1.1 1.6 4.9 -0.5 -0.6 0.3 0.8 2.1 0.9 2.2
Medication: Omeprazole (e.g. Zanprol) 1.5 1.9 2.8 1.2 1.7 0.8 -0.9 -1.4 -1.6 -1.7
Pain experienced in last month 0.7 1.1 2.8 1.7 1.5 1.1 -0.4 0.4 -0.8 0.8
Supplements: Calcium 0.6 0.6 2.2 -1.5 -0.9 -0.7 0.3 0.6 0.7 -0.4
Basal cell carcinoma (self-reported) 0.4 0.5 0.9 -0.1 0.7 0.9 0.7 0.9 0.6 0.8
Heart attack/myocardial infarction (self-reported) 0.2 0.2 0.6 -0.0 0.8 0.3 -0.4 0.7 0.3 -0.2
Deep venous thrombosis (DVT) (self-reported) 1.1 1.5 4.2 1.0 1.6 2.0 0.2 0.6 0.7 1.2
Heart disease (siblings) 0.4 0.4 1.3 1.0 0.4 0.6 0.4 0.4 -0.1 1.2
Alcohol drinker status: Previous 1.2 1.4 5.3 0.9 0.9 -0.6 -2.3 -1.1 -0.8 -0.7
Pack years of smoking 0.5 0.7 1.7 -0.2 -0.7 -1.3 -0.7 -0.9 -0.6 -1.2
Impedance of whole body 1.2 6.2 17.4 0.5 -0.6 -1.0 -1.4 -3.5 -3.3 -4.2
Leg fat mass (left) 1.1 4.5 12.8 -2.0 -1.2 0.1 2.9 1.8 3.6 1.1
Arm predicted mass (left) 1.1 5.4 13.8 -1.0 1.1 -2.0 -2.0 -3.7 -2.6 -2.6