[Hub]/) : Traits : Forced vital capacity (FVC) : ← →

chr4:105,373,669-107,622,327

Best TWAS P=7.44e-17 · Best GWAS P=2.32e-19 conditioned to 0.0371

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
11	GTEx	Esophagus Gastroesophageal Junction	PPA2	0.29	0.15	lasso	5	0.14	8.8e-06	-9.0	-8.3	7.4e-17	0.88	0.01	0.99	TRUE
27	The Cancer Genome Atlas	Breast Invasive Carcinoma	INTS12	0.04	0.03	blup	49	0.04	7.1e-08	7.0	-7.7	1.6e-14	0.09	0.01	0.99	TRUE
12	GTEx	Esophagus Mucosa	PPA2	0.18	0.06	enet	14	0.12	2.5e-08	6.5	-8.3	1.1e-16	0.76	0.01	0.99	FALSE
4	GTEx	Artery Aorta	PPA2	0.11	-0.01	enet	24	0.01	1.6e-01	-9.0	-8.0	1.4e-15	0.69	0.02	0.79	FALSE
32	The Cancer Genome Atlas	Brain Lower Grade Glioma	GSTCD	0.07	0.05	lasso	4	0.04	6.6e-05	7.4	7.5	4.2e-14	-0.09	0.01	0.98	FALSE
34	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	INTS12	0.22	0.15	lasso	6	0.16	2.3e-07	7.2	-7.5	5.6e-14	0.05	0.02	0.97	FALSE
10	GTEx	Cells Transformed fibroblasts	INTS12	0.15	0.16	lasso	9	0.17	9.5e-13	7.2	-7.5	6.2e-14	0.07	1.00	0.00	FALSE
28	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	INTS12	0.12	0.06	blup	50	0.08	1.2e-04	7.3	-7.5	6.8e-14	0.10	0.01	0.98	FALSE
1	CommonMind	Brain Pre-frontal Cortex	INTS12	0.06	0.06	enet	5	0.05	2.9e-07	7.4	-7.5	9.1e-14	0.08	0.99	0.00	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	GSTCD	0.16	0.07	lasso	17	0.03	4.3e-02	7.2	7.4	1.4e-13	-0.07	0.39	0.04	FALSE
23	GTEx	Thyroid	INTS12	0.07	0.05	lasso	7	0.03	1.2e-03	7.3	-7.4	1.7e-13	0.08	0.86	0.01	FALSE
29	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	INTS12	0.03	0.02	blup	49	0.02	6.4e-03	7.4	-7.3	2.2e-13	0.11	0.01	0.87	FALSE
30	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	INTS12	0.08	0.10	lasso	2	0.10	2.9e-11	7.3	-7.3	2.6e-13	0.08	0.01	0.99	FALSE
36	The Cancer Genome Atlas	Stomach Adenocarcinoma	GSTCD	0.04	0.06	lasso	1	0.05	9.1e-05	7.3	7.3	4.0e-13	-0.09	0.02	0.92	FALSE
13	GTEx	Esophagus Muscularis	INTS12	0.12	0.10	lasso	15	0.10	1.3e-06	7.3	-7.2	6.2e-13	0.06	0.97	0.00	FALSE
18	GTEx	Ovary	PPA2	0.18	0.10	lasso	3	0.14	2.2e-04	-5.9	-7.2	7.3e-13	0.71	0.03	0.85	FALSE
17	GTEx	Nerve Tibial	GSTCD	0.09	0.03	enet	16	0.02	1.3e-02	6.7	7.1	1.0e-12	-0.12	0.59	0.02	FALSE
5	GTEx	Artery Aorta	INTS12	0.13	0.14	lasso	3	0.14	6.5e-08	7.0	-7.1	1.5e-12	0.08	0.95	0.01	FALSE
33	The Cancer Genome Atlas	Lung Adenocarcinoma	INTS12	0.08	0.10	enet	11	0.10	9.9e-12	7.4	-7.0	2.0e-12	0.10	0.01	0.99	FALSE
22	GTEx	Skin Sun Exposed Lower leg	TET2	0.09	0.01	enet	18	0.02	3.6e-03	-8.7	-7.0	2.3e-12	0.65	0.02	0.89	FALSE
7	GTEx	Brain Cortex	PPA2	0.14	0.09	lasso	9	0.09	1.6e-03	-6.7	-6.9	6.6e-12	0.81	0.06	0.60	FALSE
37	The Cancer Genome Atlas	Thyroid Carcinoma	INTS12	0.11	0.09	blup	49	0.11	1.3e-10	7.3	-6.8	8.5e-12	0.12	0.01	0.99	FALSE
2	GTEx	Adipose Subcutaneous	GSTCD	0.08	0.07	lasso	8	0.07	2.9e-06	5.9	6.8	1.4e-11	-0.12	0.96	0.00	FALSE
21	GTEx	Skin Sun Exposed Lower leg	GSTCD	0.08	0.02	lasso	6	0.01	3.8e-02	6.2	6.7	1.7e-11	-0.14	0.79	0.01	FALSE
16	GTEx	Nerve Tibial	PPA2	0.13	0.07	enet	23	0.07	2.1e-05	-5.9	-6.6	3.4e-11	0.61	0.32	0.52	FALSE
31	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	INTS12	0.32	0.00	blup	49	0.06	1.8e-04	7.0	-6.5	6.2e-11	0.08	0.01	0.80	FALSE
26	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	INTS12	0.04	0.03	blup	51	0.04	3.9e-04	7.2	-6.5	1.1e-10	0.13	0.01	0.96	FALSE
19	GTEx	Pituitary	GSTCD	0.28	0.14	lasso	5	0.09	2.8e-03	7.0	6.3	2.7e-10	-0.11	0.35	0.04	FALSE
38	The Cancer Genome Atlas	Thyroid Carcinoma	PPA2	0.04	0.02	blup	84	0.04	6.1e-05	-5.9	-6.0	2.6e-09	0.73	0.14	0.66	FALSE
24	ROSMAP	Brain Pre-frontal Cortex	PPA2	0.32	0.38	lasso	2	0.38	1.1e-51	5.6	-5.9	3.1e-09	0.41	1.00	0.00	FALSE
9	GTEx	Cells Transformed fibroblasts	PPA2	0.11	0.03	lasso	3	0.01	6.5e-02	-4.7	-5.8	8.9e-09	0.62	0.31	0.33	FALSE
3	GTEx	Adipose Visceral Omentum	PPA2	0.15	0.04	lasso	6	0.05	9.1e-04	5.6	-5.7	1.2e-08	0.38	0.13	0.14	FALSE
6	GTEx	Brain Cerebellum	PPA2	0.22	0.01	lasso	4	0.03	3.7e-02	-5.9	-5.7	1.3e-08	0.59	0.08	0.20	FALSE
35	The Cancer Genome Atlas	Prostate Adenocarcinoma	INTS12	0.15	0.11	lasso	3	0.17	2.1e-17	2.6	-5.5	3.2e-08	0.14	0.05	0.95	FALSE
20	GTEx	Skin Sun Exposed Lower leg	PPA2	0.09	0.07	lasso	3	0.04	4.3e-04	5.6	-5.4	5.8e-08	0.31	0.66	0.04	FALSE
15	GTEx	Lung	NPNT	0.07	0.02	enet	24	0.04	2.3e-04	7.3	-5.3	1.4e-07	0.01	0.03	0.94	FALSE
14	GTEx	Heart Atrial Appendage	PPA2	0.15	0.05	lasso	7	0.06	7.4e-04	-6.3	-5.2	2.2e-07	0.66	0.19	0.51	FALSE
25	YFS	Blood	PPA2	0.22	0.05	lasso	19	0.12	9.7e-38	-3.0	5.1	2.7e-07	-0.50	1.00	0.00	FALSE